-- dump date 20140619_065746 -- class Genbank::misc_feature -- table misc_feature_note -- id note 471854000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 471854000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 471854000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854000004 Walker A motif; other site 471854000005 ATP binding site [chemical binding]; other site 471854000006 Walker B motif; other site 471854000007 arginine finger; other site 471854000008 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 471854000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 471854000010 DnaA box-binding interface [nucleotide binding]; other site 471854000011 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 471854000012 Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720 471854000013 recombinase A; Provisional; Region: recA; PRK09354 471854000014 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 471854000015 hexamer interface [polypeptide binding]; other site 471854000016 Walker A motif; other site 471854000017 ATP binding site [chemical binding]; other site 471854000018 Walker B motif; other site 471854000019 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 471854000020 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 471854000021 phosphodiesterase; Provisional; Region: PRK12704 471854000022 KH domain; Region: KH_1; pfam00013 471854000023 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471854000024 Zn2+ binding site [ion binding]; other site 471854000025 Mg2+ binding site [ion binding]; other site 471854000026 Cell division protein ZapA; Region: ZapA; pfam05164 471854000027 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 471854000028 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 471854000029 putative tRNA-binding site [nucleotide binding]; other site 471854000030 B3/4 domain; Region: B3_4; pfam03483 471854000031 tRNA synthetase B5 domain; Region: B5; pfam03484 471854000032 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 471854000033 dimer interface [polypeptide binding]; other site 471854000034 motif 1; other site 471854000035 motif 3; other site 471854000036 motif 2; other site 471854000037 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 471854000038 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 471854000039 Response regulator receiver domain; Region: Response_reg; pfam00072 471854000040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854000041 active site 471854000042 phosphorylation site [posttranslational modification] 471854000043 intermolecular recognition site; other site 471854000044 dimerization interface [polypeptide binding]; other site 471854000045 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 471854000046 putative hydrolase; Provisional; Region: PRK02113 471854000047 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 471854000048 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 471854000049 Moco binding site; other site 471854000050 metal coordination site [ion binding]; other site 471854000051 Protein of unknown function (DUF819); Region: DUF819; cl02317 471854000052 DinB family; Region: DinB; cl17821 471854000053 DinB superfamily; Region: DinB_2; pfam12867 471854000054 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 471854000055 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471854000056 catalytic loop [active] 471854000057 iron binding site [ion binding]; other site 471854000058 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 471854000059 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 471854000060 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 471854000061 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471854000062 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471854000063 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 471854000064 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 471854000065 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 471854000066 active site 471854000067 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 471854000068 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 471854000069 active site 471854000070 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 471854000071 DinB superfamily; Region: DinB_2; pfam12867 471854000072 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 471854000073 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 471854000074 catalytic residues [active] 471854000075 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854000076 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 471854000077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854000078 HD domain; Region: HD_4; pfam13328 471854000079 translation initiation factor IF-2; Region: IF-2; TIGR00487 471854000080 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471854000081 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 471854000082 G1 box; other site 471854000083 putative GEF interaction site [polypeptide binding]; other site 471854000084 GTP/Mg2+ binding site [chemical binding]; other site 471854000085 Switch I region; other site 471854000086 G2 box; other site 471854000087 G3 box; other site 471854000088 Switch II region; other site 471854000089 G4 box; other site 471854000090 G5 box; other site 471854000091 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 471854000092 Translation-initiation factor 2; Region: IF-2; pfam11987 471854000093 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 471854000094 transcription termination factor NusA; Region: NusA; TIGR01953 471854000095 NusA N-terminal domain; Region: NusA_N; pfam08529 471854000096 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 471854000097 RNA binding site [nucleotide binding]; other site 471854000098 homodimer interface [polypeptide binding]; other site 471854000099 NusA-like KH domain; Region: KH_5; pfam13184 471854000100 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 471854000101 G-X-X-G motif; other site 471854000102 ribosome maturation protein RimP; Reviewed; Region: PRK00092 471854000103 Sm and related proteins; Region: Sm_like; cl00259 471854000104 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 471854000105 putative oligomer interface [polypeptide binding]; other site 471854000106 putative RNA binding site [nucleotide binding]; other site 471854000107 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 471854000108 putative catalytic site [active] 471854000109 putative metal binding site [ion binding]; other site 471854000110 putative phosphate binding site [ion binding]; other site 471854000111 Galactose oxidase, central domain; Region: Kelch_3; cl02701 471854000112 Galactose oxidase, central domain; Region: Kelch_3; cl02701 471854000113 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 471854000114 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 471854000115 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 471854000116 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 471854000117 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 471854000118 Protein export membrane protein; Region: SecD_SecF; cl14618 471854000119 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854000120 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854000121 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854000122 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 471854000123 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 471854000124 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 471854000125 Na binding site [ion binding]; other site 471854000126 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 471854000127 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 471854000128 NADP binding site [chemical binding]; other site 471854000129 active site 471854000130 putative substrate binding site [chemical binding]; other site 471854000131 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 471854000132 Bacterial sugar transferase; Region: Bac_transf; pfam02397 471854000133 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 471854000134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 471854000135 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854000136 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 471854000137 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854000138 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 471854000139 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471854000140 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854000141 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 471854000142 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 471854000143 trimer interface [polypeptide binding]; other site 471854000144 active site 471854000145 substrate binding site [chemical binding]; other site 471854000146 CoA binding site [chemical binding]; other site 471854000147 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854000148 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 471854000149 putative ADP-binding pocket [chemical binding]; other site 471854000150 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 471854000151 trimer interface [polypeptide binding]; other site 471854000152 active site 471854000153 substrate binding site [chemical binding]; other site 471854000154 CoA binding site [chemical binding]; other site 471854000155 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854000156 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471854000157 active site 471854000158 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 471854000159 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 471854000160 FMN binding site [chemical binding]; other site 471854000161 dimer interface [polypeptide binding]; other site 471854000162 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 471854000163 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 471854000164 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471854000165 putative NAD(P) binding site [chemical binding]; other site 471854000166 active site 471854000167 putative substrate binding site [chemical binding]; other site 471854000168 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 471854000169 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 471854000170 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471854000171 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 471854000172 Chain length determinant protein; Region: Wzz; cl15801 471854000173 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 471854000174 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 471854000175 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 471854000176 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471854000177 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471854000178 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 471854000179 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 471854000180 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 471854000181 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471854000182 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471854000183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854000184 Walker A/P-loop; other site 471854000185 ATP binding site [chemical binding]; other site 471854000186 Q-loop/lid; other site 471854000187 ABC transporter signature motif; other site 471854000188 Walker B; other site 471854000189 D-loop; other site 471854000190 H-loop/switch region; other site 471854000191 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854000192 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 471854000193 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 471854000194 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471854000195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854000196 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854000197 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 471854000198 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471854000199 NAD(P) binding site [chemical binding]; other site 471854000200 catalytic residues [active] 471854000201 Protein of unknown function (DUF779); Region: DUF779; pfam05610 471854000202 helicase 45; Provisional; Region: PTZ00424 471854000203 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471854000204 ATP binding site [chemical binding]; other site 471854000205 Mg++ binding site [ion binding]; other site 471854000206 motif III; other site 471854000207 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854000208 nucleotide binding region [chemical binding]; other site 471854000209 ATP-binding site [chemical binding]; other site 471854000210 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 471854000211 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 471854000212 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 471854000213 active site 471854000214 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854000215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 471854000216 active site 471854000217 phosphorylation site [posttranslational modification] 471854000218 intermolecular recognition site; other site 471854000219 dimerization interface [polypeptide binding]; other site 471854000220 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 471854000221 DNA binding residues [nucleotide binding] 471854000222 dimerization interface [polypeptide binding]; other site 471854000223 LVIVD repeat; Region: LVIVD; pfam08309 471854000224 Utp8 family; Region: Utp8; pfam10395 471854000225 methionine sulfoxide reductase B; Provisional; Region: PRK00222 471854000226 SelR domain; Region: SelR; pfam01641 471854000227 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 471854000228 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471854000229 Peptidase family M23; Region: Peptidase_M23; pfam01551 471854000230 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471854000231 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 471854000232 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471854000233 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471854000234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854000235 binding surface 471854000236 Tetratricopeptide repeat; Region: TPR_16; pfam13432 471854000237 TPR motif; other site 471854000238 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471854000239 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471854000240 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471854000241 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 471854000242 ligand binding site [chemical binding]; other site 471854000243 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 471854000244 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471854000245 FeS/SAM binding site; other site 471854000246 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 471854000247 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 471854000248 trmE is a tRNA modification GTPase; Region: trmE; cd04164 471854000249 G1 box; other site 471854000250 GTP/Mg2+ binding site [chemical binding]; other site 471854000251 Switch I region; other site 471854000252 G2 box; other site 471854000253 Switch II region; other site 471854000254 G3 box; other site 471854000255 G4 box; other site 471854000256 G5 box; other site 471854000257 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 471854000258 Domain of unknown function (DUF955); Region: DUF955; pfam06114 471854000259 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 471854000260 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 471854000261 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471854000262 Beta-lactamase; Region: Beta-lactamase; pfam00144 471854000263 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 471854000264 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 471854000265 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 471854000266 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 471854000267 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854000268 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 471854000269 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 471854000270 N-terminal plug; other site 471854000271 ligand-binding site [chemical binding]; other site 471854000272 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 471854000273 Tetraspanin family; Region: Tetraspannin; pfam00335 471854000274 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 471854000275 active site 471854000276 catalytic triad [active] 471854000277 oxyanion hole [active] 471854000278 Protein of unknown function, DUF488; Region: DUF488; cl01246 471854000279 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 471854000280 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 471854000281 active site 471854000282 catalytic site [active] 471854000283 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 471854000284 active site 471854000285 catalytic triad [active] 471854000286 oxyanion hole [active] 471854000287 Uncharacterized proteins similar to Bacteroides ovatus 4320; Region: Bacova_04320_like; cd12190 471854000288 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 471854000289 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 471854000290 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 471854000291 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 471854000292 dimerization interface [polypeptide binding]; other site 471854000293 ATP binding site [chemical binding]; other site 471854000294 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 471854000295 dimerization interface [polypeptide binding]; other site 471854000296 ATP binding site [chemical binding]; other site 471854000297 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 471854000298 putative active site [active] 471854000299 catalytic triad [active] 471854000300 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471854000301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471854000302 Bacterial transcriptional repressor; Region: TetR; pfam13972 471854000303 Cupin domain; Region: Cupin_2; pfam07883 471854000304 Domain of unknown function (DUF303); Region: DUF303; pfam03629 471854000305 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471854000306 catalytic triad [active] 471854000307 Domain of unknown function (DUF303); Region: DUF303; pfam03629 471854000308 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 471854000309 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 471854000310 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 471854000311 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 471854000312 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 471854000313 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 471854000314 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 471854000315 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_2; cd08974 471854000316 putative DNA binding site [nucleotide binding]; other site 471854000317 catalytic residue [active] 471854000318 putative H2TH interface [polypeptide binding]; other site 471854000319 putative catalytic residues [active] 471854000320 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471854000321 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 471854000322 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471854000323 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 471854000324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854000325 S-adenosylmethionine binding site [chemical binding]; other site 471854000326 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 471854000327 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 471854000328 NAD binding site [chemical binding]; other site 471854000329 catalytic Zn binding site [ion binding]; other site 471854000330 structural Zn binding site [ion binding]; other site 471854000331 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 471854000332 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854000333 FtsX-like permease family; Region: FtsX; pfam02687 471854000334 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854000335 FtsX-like permease family; Region: FtsX; pfam02687 471854000336 Predicted transcriptional regulators [Transcription]; Region: COG1695 471854000337 Transcriptional regulator PadR-like family; Region: PadR; cl17335 471854000338 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 471854000339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471854000340 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 471854000341 putative dimerization interface [polypeptide binding]; other site 471854000342 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 471854000343 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 471854000344 HEAT repeats; Region: HEAT_2; pfam13646 471854000345 HEAT repeats; Region: HEAT_2; pfam13646 471854000346 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 471854000347 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854000348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854000349 active site 471854000350 phosphorylation site [posttranslational modification] 471854000351 intermolecular recognition site; other site 471854000352 dimerization interface [polypeptide binding]; other site 471854000353 LytTr DNA-binding domain; Region: LytTR; smart00850 471854000354 Two component regulator propeller; Region: Reg_prop; pfam07494 471854000355 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 471854000356 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 471854000357 Histidine kinase; Region: His_kinase; pfam06580 471854000358 glycogen branching enzyme; Provisional; Region: PRK12313 471854000359 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 471854000360 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 471854000361 active site 471854000362 catalytic site [active] 471854000363 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 471854000364 trehalose synthase; Region: treS_nterm; TIGR02456 471854000365 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 471854000366 active site 471854000367 catalytic site [active] 471854000368 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 471854000369 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 471854000370 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 471854000371 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 471854000372 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 471854000373 active site 471854000374 homodimer interface [polypeptide binding]; other site 471854000375 catalytic site [active] 471854000376 acceptor binding site [chemical binding]; other site 471854000377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854000378 Response regulator receiver domain; Region: Response_reg; pfam00072 471854000379 active site 471854000380 phosphorylation site [posttranslational modification] 471854000381 intermolecular recognition site; other site 471854000382 dimerization interface [polypeptide binding]; other site 471854000383 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 471854000384 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 471854000385 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 471854000386 active site 471854000387 catalytic site [active] 471854000388 4-alpha-glucanotransferase; Provisional; Region: PRK14508 471854000389 Domain of unknown function (DUF4202); Region: DUF4202; pfam13875 471854000390 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854000391 von Willebrand factor; Region: vWF_A; pfam12450 471854000392 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 471854000393 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 471854000394 metal ion-dependent adhesion site (MIDAS); other site 471854000395 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 471854000396 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854000397 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854000398 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854000399 DNA binding residues [nucleotide binding] 471854000400 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471854000401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854000402 active site 471854000403 phosphorylation site [posttranslational modification] 471854000404 intermolecular recognition site; other site 471854000405 dimerization interface [polypeptide binding]; other site 471854000406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 471854000407 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471854000408 intermolecular recognition site; other site 471854000409 active site 471854000410 dimerization interface [polypeptide binding]; other site 471854000411 Bacterial sugar transferase; Region: Bac_transf; pfam02397 471854000412 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 471854000413 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 471854000414 trimer interface [polypeptide binding]; other site 471854000415 active site 471854000416 substrate binding site [chemical binding]; other site 471854000417 CoA binding site [chemical binding]; other site 471854000418 Outer membrane efflux protein; Region: OEP; pfam02321 471854000419 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 471854000420 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 471854000421 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471854000422 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471854000423 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 471854000424 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 471854000425 DXD motif; other site 471854000426 Core-2/I-Branching enzyme; Region: Branch; pfam02485 471854000427 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 471854000428 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854000429 putative homodimer interface [polypeptide binding]; other site 471854000430 CHASE3 domain; Region: CHASE3; pfam05227 471854000431 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471854000432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854000433 dimer interface [polypeptide binding]; other site 471854000434 phosphorylation site [posttranslational modification] 471854000435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854000436 ATP binding site [chemical binding]; other site 471854000437 Mg2+ binding site [ion binding]; other site 471854000438 G-X-G motif; other site 471854000439 Response regulator receiver domain; Region: Response_reg; pfam00072 471854000440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854000441 active site 471854000442 phosphorylation site [posttranslational modification] 471854000443 intermolecular recognition site; other site 471854000444 dimerization interface [polypeptide binding]; other site 471854000445 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 471854000446 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854000447 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 471854000448 active site 471854000449 active site 471854000450 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854000451 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471854000452 active site 471854000453 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471854000454 active site 471854000455 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 471854000456 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 471854000457 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 471854000458 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 471854000459 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 471854000460 GDP-Fucose binding site [chemical binding]; other site 471854000461 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 471854000462 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854000463 putative homodimer interface [polypeptide binding]; other site 471854000464 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471854000465 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 471854000466 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471854000467 anti sigma factor interaction site; other site 471854000468 regulatory phosphorylation site [posttranslational modification]; other site 471854000469 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471854000470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854000471 active site 471854000472 phosphorylation site [posttranslational modification] 471854000473 intermolecular recognition site; other site 471854000474 dimerization interface [polypeptide binding]; other site 471854000475 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 471854000476 Poxvirus protein I5; Region: Pox_I5; pfam04713 471854000477 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471854000478 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 471854000479 Probable Catalytic site; other site 471854000480 metal-binding site 471854000481 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 471854000482 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471854000483 DXD motif; other site 471854000484 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 471854000485 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 471854000486 mce related protein; Region: MCE; pfam02470 471854000487 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 471854000488 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 471854000489 Walker A/P-loop; other site 471854000490 ATP binding site [chemical binding]; other site 471854000491 Q-loop/lid; other site 471854000492 ABC transporter signature motif; other site 471854000493 Walker B; other site 471854000494 D-loop; other site 471854000495 H-loop/switch region; other site 471854000496 Permease; Region: Permease; pfam02405 471854000497 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 471854000498 EcsC protein family; Region: EcsC; pfam12787 471854000499 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854000500 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 471854000501 putative substrate binding site [chemical binding]; other site 471854000502 active site 471854000503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854000504 S-adenosylmethionine binding site [chemical binding]; other site 471854000505 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 471854000506 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 471854000507 ligand binding site [chemical binding]; other site 471854000508 active site 471854000509 UGI interface [polypeptide binding]; other site 471854000510 catalytic site [active] 471854000511 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 471854000512 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981 471854000513 Zn binding site [ion binding]; other site 471854000514 DinB superfamily; Region: DinB_2; pfam12867 471854000515 helicase 45; Provisional; Region: PTZ00424 471854000516 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471854000517 ATP binding site [chemical binding]; other site 471854000518 Mg++ binding site [ion binding]; other site 471854000519 motif III; other site 471854000520 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854000521 nucleotide binding region [chemical binding]; other site 471854000522 ATP-binding site [chemical binding]; other site 471854000523 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 471854000524 RNA binding site [nucleotide binding]; other site 471854000525 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 471854000526 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 471854000527 hexamer interface [polypeptide binding]; other site 471854000528 ligand binding site [chemical binding]; other site 471854000529 putative active site [active] 471854000530 NAD(P) binding site [chemical binding]; other site 471854000531 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471854000532 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471854000533 putative DNA binding site [nucleotide binding]; other site 471854000534 putative Zn2+ binding site [ion binding]; other site 471854000535 AsnC family; Region: AsnC_trans_reg; pfam01037 471854000536 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471854000537 Radical SAM superfamily; Region: Radical_SAM; pfam04055 471854000538 FeS/SAM binding site; other site 471854000539 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 471854000540 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471854000541 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471854000542 P-loop; other site 471854000543 Magnesium ion binding site [ion binding]; other site 471854000544 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471854000545 Magnesium ion binding site [ion binding]; other site 471854000546 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 471854000547 ParB-like nuclease domain; Region: ParBc; pfam02195 471854000548 KorB domain; Region: KorB; pfam08535 471854000549 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 471854000550 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 471854000551 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 471854000552 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 471854000553 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471854000554 Catalytic site [active] 471854000555 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471854000556 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 471854000557 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471854000558 Catalytic site [active] 471854000559 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471854000560 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 471854000561 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 471854000562 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 471854000563 catalytic site [active] 471854000564 active site 471854000565 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 471854000566 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 471854000567 DNA protecting protein DprA; Region: dprA; TIGR00732 471854000568 Divergent AAA domain; Region: AAA_4; pfam04326 471854000569 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 471854000570 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471854000571 prolyl-tRNA synthetase; Provisional; Region: PRK08661 471854000572 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 471854000573 dimer interface [polypeptide binding]; other site 471854000574 motif 1; other site 471854000575 active site 471854000576 motif 2; other site 471854000577 motif 3; other site 471854000578 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 471854000579 anticodon binding site; other site 471854000580 zinc-binding site [ion binding]; other site 471854000581 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 471854000582 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 471854000583 ADP binding site [chemical binding]; other site 471854000584 magnesium binding site [ion binding]; other site 471854000585 putative shikimate binding site; other site 471854000586 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 471854000587 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 471854000588 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 471854000589 dihydropteroate synthase; Region: DHPS; TIGR01496 471854000590 substrate binding pocket [chemical binding]; other site 471854000591 dimer interface [polypeptide binding]; other site 471854000592 inhibitor binding site; inhibition site 471854000593 Uncharacterized conserved protein [Function unknown]; Region: COG1624 471854000594 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 471854000595 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 471854000596 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 471854000597 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 471854000598 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471854000599 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471854000600 ABC transporter; Region: ABC_tran_2; pfam12848 471854000601 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471854000602 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471854000603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854000604 S-adenosylmethionine binding site [chemical binding]; other site 471854000605 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 471854000606 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 471854000607 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471854000608 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 471854000609 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 471854000610 AAA domain; Region: AAA_30; pfam13604 471854000611 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471854000612 Family description; Region: UvrD_C_2; pfam13538 471854000613 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 471854000614 FOG: CBS domain [General function prediction only]; Region: COG0517 471854000615 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471854000616 nudix motif; other site 471854000617 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 471854000618 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 471854000619 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471854000620 active site 471854000621 nucleotide binding site [chemical binding]; other site 471854000622 HIGH motif; other site 471854000623 KMSKS motif; other site 471854000624 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 471854000625 active site 471854000626 Ap6A binding site [chemical binding]; other site 471854000627 nudix motif; other site 471854000628 metal binding site [ion binding]; metal-binding site 471854000629 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471854000630 Domain of unknown function DUF21; Region: DUF21; pfam01595 471854000631 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471854000632 Transporter associated domain; Region: CorC_HlyC; smart01091 471854000633 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471854000634 active site 471854000635 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471854000636 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471854000637 active site 471854000638 catalytic tetrad [active] 471854000639 polyphosphate kinase; Provisional; Region: PRK05443 471854000640 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 471854000641 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 471854000642 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 471854000643 domain interface [polypeptide binding]; other site 471854000644 active site 471854000645 catalytic site [active] 471854000646 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 471854000647 domain interface [polypeptide binding]; other site 471854000648 active site 471854000649 catalytic site [active] 471854000650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471854000651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471854000652 WHG domain; Region: WHG; pfam13305 471854000653 serine O-acetyltransferase; Region: cysE; TIGR01172 471854000654 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 471854000655 trimer interface [polypeptide binding]; other site 471854000656 active site 471854000657 substrate binding site [chemical binding]; other site 471854000658 CoA binding site [chemical binding]; other site 471854000659 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471854000660 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854000661 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 471854000662 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 471854000663 catalytic nucleophile [active] 471854000664 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 471854000665 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471854000666 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 471854000667 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 471854000668 Malic enzyme, N-terminal domain; Region: malic; pfam00390 471854000669 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 471854000670 putative NAD(P) binding site [chemical binding]; other site 471854000671 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 471854000672 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 471854000673 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 471854000674 Mg++ binding site [ion binding]; other site 471854000675 putative catalytic motif [active] 471854000676 substrate binding site [chemical binding]; other site 471854000677 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471854000678 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 471854000679 metal-binding site 471854000680 putative acyl transferase; Provisional; Region: PRK10502 471854000681 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 471854000682 putative trimer interface [polypeptide binding]; other site 471854000683 putative active site [active] 471854000684 putative substrate binding site [chemical binding]; other site 471854000685 putative CoA binding site [chemical binding]; other site 471854000686 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854000687 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 471854000688 putative metal binding site; other site 471854000689 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854000690 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 471854000691 putative ADP-binding pocket [chemical binding]; other site 471854000692 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854000693 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471854000694 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471854000695 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854000696 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 471854000697 dimer interface [polypeptide binding]; other site 471854000698 putative metal binding site [ion binding]; other site 471854000699 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 471854000700 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854000701 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854000702 active site 471854000703 PAS domain S-box; Region: sensory_box; TIGR00229 471854000704 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854000705 putative active site [active] 471854000706 heme pocket [chemical binding]; other site 471854000707 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854000708 PAS domain; Region: PAS_9; pfam13426 471854000709 putative active site [active] 471854000710 heme pocket [chemical binding]; other site 471854000711 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471854000712 PAS domain; Region: PAS_8; pfam13188 471854000713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854000714 dimer interface [polypeptide binding]; other site 471854000715 phosphorylation site [posttranslational modification] 471854000716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854000717 ATP binding site [chemical binding]; other site 471854000718 Mg2+ binding site [ion binding]; other site 471854000719 G-X-G motif; other site 471854000720 Response regulator receiver domain; Region: Response_reg; pfam00072 471854000721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854000722 active site 471854000723 phosphorylation site [posttranslational modification] 471854000724 intermolecular recognition site; other site 471854000725 dimerization interface [polypeptide binding]; other site 471854000726 Response regulator receiver domain; Region: Response_reg; pfam00072 471854000727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854000728 active site 471854000729 phosphorylation site [posttranslational modification] 471854000730 intermolecular recognition site; other site 471854000731 dimerization interface [polypeptide binding]; other site 471854000732 short chain dehydrogenase; Provisional; Region: PRK06701 471854000733 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 471854000734 NAD binding site [chemical binding]; other site 471854000735 metal binding site [ion binding]; metal-binding site 471854000736 active site 471854000737 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471854000738 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471854000739 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 471854000740 Uncharacterized subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u3; cd12832 471854000741 oligomer interface [polypeptide binding]; other site 471854000742 metal binding site [ion binding]; metal-binding site 471854000743 putative Cl binding site [ion binding]; other site 471854000744 basic sphincter; other site 471854000745 hydrophobic gate; other site 471854000746 periplasmic entrance; other site 471854000747 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471854000748 Interdomain contacts; other site 471854000749 Cytokine receptor motif; other site 471854000750 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471854000751 Interdomain contacts; other site 471854000752 Cytokine receptor motif; other site 471854000753 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471854000754 Interdomain contacts; other site 471854000755 Cytokine receptor motif; other site 471854000756 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471854000757 Interdomain contacts; other site 471854000758 Cytokine receptor motif; other site 471854000759 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854000760 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 471854000761 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 471854000762 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471854000763 ATP binding site [chemical binding]; other site 471854000764 putative Mg++ binding site [ion binding]; other site 471854000765 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854000766 nucleotide binding region [chemical binding]; other site 471854000767 ATP-binding site [chemical binding]; other site 471854000768 Protein of unknown function, DUF481; Region: DUF481; cl01213 471854000769 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854000770 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854000771 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471854000772 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854000773 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 471854000774 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854000775 active site 471854000776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854000777 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 471854000778 NAD(P) binding site [chemical binding]; other site 471854000779 active site 471854000780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 471854000781 non-specific DNA binding site [nucleotide binding]; other site 471854000782 salt bridge; other site 471854000783 sequence-specific DNA binding site [nucleotide binding]; other site 471854000784 DNA topoisomerase III; Provisional; Region: PRK07726 471854000785 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 471854000786 active site 471854000787 putative interdomain interaction site [polypeptide binding]; other site 471854000788 putative metal-binding site [ion binding]; other site 471854000789 putative nucleotide binding site [chemical binding]; other site 471854000790 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 471854000791 domain I; other site 471854000792 DNA binding groove [nucleotide binding] 471854000793 phosphate binding site [ion binding]; other site 471854000794 domain II; other site 471854000795 domain III; other site 471854000796 nucleotide binding site [chemical binding]; other site 471854000797 catalytic site [active] 471854000798 domain IV; other site 471854000799 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 471854000800 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 471854000801 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471854000802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854000803 active site 471854000804 phosphorylation site [posttranslational modification] 471854000805 intermolecular recognition site; other site 471854000806 dimerization interface [polypeptide binding]; other site 471854000807 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471854000808 DNA binding site [nucleotide binding] 471854000809 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 471854000810 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471854000811 dimerization interface [polypeptide binding]; other site 471854000812 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854000813 dimer interface [polypeptide binding]; other site 471854000814 phosphorylation site [posttranslational modification] 471854000815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854000816 ATP binding site [chemical binding]; other site 471854000817 Mg2+ binding site [ion binding]; other site 471854000818 G-X-G motif; other site 471854000819 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 471854000820 Methane oxygenase PmoA; Region: PmoA; pfam14100 471854000821 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 471854000822 HEAT repeats; Region: HEAT_2; pfam13646 471854000823 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 471854000824 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 471854000825 HicB family; Region: HicB; pfam05534 471854000826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 471854000827 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 471854000828 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854000829 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471854000830 active site 471854000831 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 471854000832 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471854000833 putative catalytic residue [active] 471854000834 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471854000835 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471854000836 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471854000837 catalytic residues [active] 471854000838 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471854000839 Penicillinase repressor; Region: Pencillinase_R; cl17580 471854000840 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 471854000841 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 471854000842 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 471854000843 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 471854000844 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854000845 putative metal binding site [ion binding]; other site 471854000846 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854000847 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471854000848 active site 471854000849 substrate binding site [chemical binding]; other site 471854000850 ATP binding site [chemical binding]; other site 471854000851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854000852 Coenzyme A binding pocket [chemical binding]; other site 471854000853 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854000854 PAS fold; Region: PAS_3; pfam08447 471854000855 putative active site [active] 471854000856 heme pocket [chemical binding]; other site 471854000857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854000858 putative active site [active] 471854000859 PAS fold; Region: PAS_3; pfam08447 471854000860 heme pocket [chemical binding]; other site 471854000861 PAS fold; Region: PAS; pfam00989 471854000862 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854000863 putative active site [active] 471854000864 heme pocket [chemical binding]; other site 471854000865 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 471854000866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854000867 dimer interface [polypeptide binding]; other site 471854000868 phosphorylation site [posttranslational modification] 471854000869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854000870 ATP binding site [chemical binding]; other site 471854000871 Mg2+ binding site [ion binding]; other site 471854000872 G-X-G motif; other site 471854000873 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854000874 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854000875 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854000876 Putative esterase; Region: Esterase; pfam00756 471854000877 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 471854000878 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 471854000879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854000880 NAD(P) binding site [chemical binding]; other site 471854000881 active site 471854000882 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854000883 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854000884 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854000885 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854000886 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854000887 SusD family; Region: SusD; pfam07980 471854000888 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 471854000889 Cytochrome c; Region: Cytochrom_C; pfam00034 471854000890 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471854000891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 471854000892 Putative esterase; Region: Esterase; pfam00756 471854000893 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471854000894 active site 471854000895 catalytic triad [active] 471854000896 oxyanion hole [active] 471854000897 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471854000898 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471854000899 active site 471854000900 catalytic tetrad [active] 471854000901 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 471854000902 PQQ-like domain; Region: PQQ_2; pfam13360 471854000903 Trp docking motif [polypeptide binding]; other site 471854000904 putative active site [active] 471854000905 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471854000906 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 471854000907 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 471854000908 Domain of unknown function (DUF303); Region: DUF303; pfam03629 471854000909 Domain of unknown function (DUF303); Region: DUF303; pfam03629 471854000910 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 471854000911 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854000912 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 471854000913 Probable Catalytic site; other site 471854000914 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854000915 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 471854000916 Probable Catalytic site; other site 471854000917 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471854000918 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471854000919 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 471854000920 Walker A/P-loop; other site 471854000921 ATP binding site [chemical binding]; other site 471854000922 Q-loop/lid; other site 471854000923 ABC transporter signature motif; other site 471854000924 Walker B; other site 471854000925 D-loop; other site 471854000926 H-loop/switch region; other site 471854000927 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 471854000928 active site 471854000929 DNA polymerase IV; Validated; Region: PRK02406 471854000930 DNA binding site [nucleotide binding] 471854000931 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 471854000932 active site 471854000933 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 471854000934 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854000935 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854000936 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854000937 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854000938 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854000939 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854000940 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854000941 SusD family; Region: SusD; pfam07980 471854000942 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 471854000943 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 471854000944 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 471854000945 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471854000946 active site 471854000947 metal binding site [ion binding]; metal-binding site 471854000948 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 471854000949 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 471854000950 Cytochrome P450; Region: p450; pfam00067 471854000951 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 471854000952 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 471854000953 dimerization interface [polypeptide binding]; other site 471854000954 DPS ferroxidase diiron center [ion binding]; other site 471854000955 ion pore; other site 471854000956 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 471854000957 putative amphipathic alpha helix; other site 471854000958 KTSC domain; Region: KTSC; pfam13619 471854000959 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 471854000960 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471854000961 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471854000962 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 471854000963 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 471854000964 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 471854000965 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 471854000966 Sulfatase; Region: Sulfatase; cl17466 471854000967 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 471854000968 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 471854000969 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 471854000970 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 471854000971 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 471854000972 Predicted metalloprotease [General function prediction only]; Region: COG2321 471854000973 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 471854000974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854000975 Response regulator receiver domain; Region: Response_reg; pfam00072 471854000976 active site 471854000977 phosphorylation site [posttranslational modification] 471854000978 intermolecular recognition site; other site 471854000979 dimerization interface [polypeptide binding]; other site 471854000980 PAS fold; Region: PAS_4; pfam08448 471854000981 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471854000982 PAS fold; Region: PAS_4; pfam08448 471854000983 putative active site [active] 471854000984 heme pocket [chemical binding]; other site 471854000985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854000986 dimer interface [polypeptide binding]; other site 471854000987 phosphorylation site [posttranslational modification] 471854000988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854000989 ATP binding site [chemical binding]; other site 471854000990 Mg2+ binding site [ion binding]; other site 471854000991 G-X-G motif; other site 471854000992 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854000993 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854000994 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854000995 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854000996 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854000997 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 471854000998 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854000999 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471854001000 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471854001001 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 471854001002 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 471854001003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471854001004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854001005 dimer interface [polypeptide binding]; other site 471854001006 phosphorylation site [posttranslational modification] 471854001007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854001008 ATP binding site [chemical binding]; other site 471854001009 Mg2+ binding site [ion binding]; other site 471854001010 G-X-G motif; other site 471854001011 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854001012 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854001013 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854001014 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 471854001015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854001016 non-specific DNA binding site [nucleotide binding]; other site 471854001017 salt bridge; other site 471854001018 sequence-specific DNA binding site [nucleotide binding]; other site 471854001019 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854001020 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 471854001021 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 471854001022 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854001023 Zn binding site [ion binding]; other site 471854001024 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 471854001025 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854001026 Zn binding site [ion binding]; other site 471854001027 Predicted esterase [General function prediction only]; Region: COG0400 471854001028 putative hydrolase; Provisional; Region: PRK11460 471854001029 Pirin-related protein [General function prediction only]; Region: COG1741 471854001030 Pirin; Region: Pirin; pfam02678 471854001031 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471854001032 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471854001033 ligand binding site [chemical binding]; other site 471854001034 flexible hinge region; other site 471854001035 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 471854001036 Competence-damaged protein; Region: CinA; pfam02464 471854001037 Cupin domain; Region: Cupin_2; cl17218 471854001038 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 471854001039 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 471854001040 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 471854001041 active site 471854001042 DNA binding site [nucleotide binding] 471854001043 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 471854001044 DNA binding site [nucleotide binding] 471854001045 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 471854001046 nucleotide binding site [chemical binding]; other site 471854001047 Protein of unknown function DUF72; Region: DUF72; pfam01904 471854001048 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471854001049 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471854001050 ligand binding site [chemical binding]; other site 471854001051 flexible hinge region; other site 471854001052 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854001053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854001054 ATP binding site [chemical binding]; other site 471854001055 Mg2+ binding site [ion binding]; other site 471854001056 G-X-G motif; other site 471854001057 Response regulator receiver domain; Region: Response_reg; pfam00072 471854001058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001059 active site 471854001060 phosphorylation site [posttranslational modification] 471854001061 intermolecular recognition site; other site 471854001062 dimerization interface [polypeptide binding]; other site 471854001063 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 471854001064 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471854001065 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 471854001066 YceI-like domain; Region: YceI; pfam04264 471854001067 Response regulator receiver domain; Region: Response_reg; pfam00072 471854001068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001069 active site 471854001070 phosphorylation site [posttranslational modification] 471854001071 intermolecular recognition site; other site 471854001072 dimerization interface [polypeptide binding]; other site 471854001073 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 471854001074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001075 active site 471854001076 phosphorylation site [posttranslational modification] 471854001077 intermolecular recognition site; other site 471854001078 dimerization interface [polypeptide binding]; other site 471854001079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854001080 ATP binding site [chemical binding]; other site 471854001081 Walker B motif; other site 471854001082 arginine finger; other site 471854001083 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 471854001084 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 471854001085 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 471854001086 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471854001087 Soluble P-type ATPase [General function prediction only]; Region: COG4087 471854001088 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 471854001089 putative active site [active] 471854001090 potassium-transporting ATPase subunit C; Provisional; Region: PRK14002 471854001091 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 471854001092 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 471854001093 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 471854001094 Ligand Binding Site [chemical binding]; other site 471854001095 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471854001096 dimerization interface [polypeptide binding]; other site 471854001097 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471854001098 PAS domain; Region: PAS; smart00091 471854001099 putative active site [active] 471854001100 heme pocket [chemical binding]; other site 471854001101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854001102 dimer interface [polypeptide binding]; other site 471854001103 phosphorylation site [posttranslational modification] 471854001104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854001105 ATP binding site [chemical binding]; other site 471854001106 Mg2+ binding site [ion binding]; other site 471854001107 G-X-G motif; other site 471854001108 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854001109 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471854001110 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471854001111 active site 471854001112 metal binding site [ion binding]; metal-binding site 471854001113 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854001114 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 471854001115 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 471854001116 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 471854001117 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854001118 Protein of unknown function (DUF983); Region: DUF983; cl02211 471854001119 CheB methylesterase; Region: CheB_methylest; pfam01339 471854001120 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 471854001121 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 471854001122 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 471854001123 Response regulator receiver domain; Region: Response_reg; pfam00072 471854001124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001125 active site 471854001126 phosphorylation site [posttranslational modification] 471854001127 intermolecular recognition site; other site 471854001128 dimerization interface [polypeptide binding]; other site 471854001129 CHASE3 domain; Region: CHASE3; pfam05227 471854001130 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471854001131 dimerization interface [polypeptide binding]; other site 471854001132 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471854001133 GAF domain; Region: GAF_3; pfam13492 471854001134 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854001135 dimer interface [polypeptide binding]; other site 471854001136 phosphorylation site [posttranslational modification] 471854001137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854001138 ATP binding site [chemical binding]; other site 471854001139 Mg2+ binding site [ion binding]; other site 471854001140 G-X-G motif; other site 471854001141 Response regulator receiver domain; Region: Response_reg; pfam00072 471854001142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001143 active site 471854001144 phosphorylation site [posttranslational modification] 471854001145 intermolecular recognition site; other site 471854001146 dimerization interface [polypeptide binding]; other site 471854001147 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471854001148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001149 active site 471854001150 phosphorylation site [posttranslational modification] 471854001151 intermolecular recognition site; other site 471854001152 Response regulator receiver domain; Region: Response_reg; pfam00072 471854001153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001154 active site 471854001155 phosphorylation site [posttranslational modification] 471854001156 intermolecular recognition site; other site 471854001157 dimerization interface [polypeptide binding]; other site 471854001158 Response regulator receiver domain; Region: Response_reg; pfam00072 471854001159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001160 active site 471854001161 phosphorylation site [posttranslational modification] 471854001162 intermolecular recognition site; other site 471854001163 dimerization interface [polypeptide binding]; other site 471854001164 PAS domain; Region: PAS_9; pfam13426 471854001165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854001166 dimer interface [polypeptide binding]; other site 471854001167 phosphorylation site [posttranslational modification] 471854001168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854001169 ATP binding site [chemical binding]; other site 471854001170 Mg2+ binding site [ion binding]; other site 471854001171 G-X-G motif; other site 471854001172 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 471854001173 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 471854001174 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 471854001175 active site 471854001176 catalytic site [active] 471854001177 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 471854001178 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 471854001179 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 471854001180 catalytic site [active] 471854001181 active site 471854001182 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 471854001183 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 471854001184 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 471854001185 hexamer (dimer of trimers) interface [polypeptide binding]; other site 471854001186 trimer interface [polypeptide binding]; other site 471854001187 substrate binding site [chemical binding]; other site 471854001188 Mn binding site [ion binding]; other site 471854001189 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 471854001190 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 471854001191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471854001192 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 471854001193 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 471854001194 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 471854001195 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 471854001196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854001197 D-galactonate transporter; Region: 2A0114; TIGR00893 471854001198 putative substrate translocation pore; other site 471854001199 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 471854001200 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471854001201 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 471854001202 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 471854001203 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471854001204 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471854001205 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 471854001206 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471854001207 catalytic loop [active] 471854001208 iron binding site [ion binding]; other site 471854001209 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 471854001210 active site 471854001211 catalytic triad [active] 471854001212 oxyanion hole [active] 471854001213 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 471854001214 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 471854001215 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 471854001216 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 471854001217 active site 471854001218 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471854001219 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 471854001220 PA/protease or protease-like domain interface [polypeptide binding]; other site 471854001221 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 471854001222 metal binding site [ion binding]; metal-binding site 471854001223 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 471854001224 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 471854001225 Methyltransferase domain; Region: Methyltransf_32; pfam13679 471854001226 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471854001227 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854001228 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854001229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854001230 binding surface 471854001231 TPR motif; other site 471854001232 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854001233 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854001234 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854001235 Histidine kinase; Region: HisKA_3; pfam07730 471854001236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854001237 ATP binding site [chemical binding]; other site 471854001238 Mg2+ binding site [ion binding]; other site 471854001239 G-X-G motif; other site 471854001240 hypothetical protein; Provisional; Region: PRK11820 471854001241 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 471854001242 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 471854001243 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 471854001244 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 471854001245 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 471854001246 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179 471854001247 putative ligand binding site [chemical binding]; other site 471854001248 putative NAD binding site [chemical binding]; other site 471854001249 catalytic site [active] 471854001250 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 471854001251 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 471854001252 5S rRNA interface [nucleotide binding]; other site 471854001253 CTC domain interface [polypeptide binding]; other site 471854001254 L16 interface [polypeptide binding]; other site 471854001255 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 471854001256 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 471854001257 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471854001258 active site 471854001259 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 471854001260 active site 471854001261 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 471854001262 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 471854001263 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 471854001264 active site 471854001265 HIGH motif; other site 471854001266 dimer interface [polypeptide binding]; other site 471854001267 KMSKS motif; other site 471854001268 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 471854001269 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 471854001270 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 471854001271 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 471854001272 active site 471854001273 PHP Thumb interface [polypeptide binding]; other site 471854001274 metal binding site [ion binding]; metal-binding site 471854001275 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 471854001276 generic binding surface I; other site 471854001277 generic binding surface II; other site 471854001278 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471854001279 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471854001280 catalytic residues [active] 471854001281 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471854001282 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471854001283 ligand binding site [chemical binding]; other site 471854001284 flexible hinge region; other site 471854001285 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 471854001286 active site 471854001287 catalytic residues [active] 471854001288 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471854001289 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 471854001290 inhibitor-cofactor binding pocket; inhibition site 471854001291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854001292 catalytic residue [active] 471854001293 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 471854001294 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471854001295 conserved cys residue [active] 471854001296 carboxylate-amine ligase; Provisional; Region: PRK13515 471854001297 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 471854001298 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471854001299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 471854001300 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 471854001301 Putative esterase; Region: Esterase; pfam00756 471854001302 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471854001303 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 471854001304 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 471854001305 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 471854001306 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471854001307 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471854001308 FeS/SAM binding site; other site 471854001309 Sulfatase; Region: Sulfatase; pfam00884 471854001310 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 471854001311 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 471854001312 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471854001313 glutamine synthetase; Region: PLN02284 471854001314 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 471854001315 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471854001316 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 471854001317 RNA methyltransferase, RsmE family; Region: TIGR00046 471854001318 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 471854001319 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 471854001320 Fatty acid desaturase; Region: FA_desaturase; pfam00487 471854001321 Di-iron ligands [ion binding]; other site 471854001322 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 471854001323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854001324 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471854001325 dimerization interface [polypeptide binding]; other site 471854001326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854001327 dimer interface [polypeptide binding]; other site 471854001328 phosphorylation site [posttranslational modification] 471854001329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854001330 ATP binding site [chemical binding]; other site 471854001331 Mg2+ binding site [ion binding]; other site 471854001332 G-X-G motif; other site 471854001333 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471854001334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001335 active site 471854001336 phosphorylation site [posttranslational modification] 471854001337 intermolecular recognition site; other site 471854001338 dimerization interface [polypeptide binding]; other site 471854001339 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471854001340 DNA binding site [nucleotide binding] 471854001341 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 471854001342 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 471854001343 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471854001344 E3 interaction surface; other site 471854001345 lipoyl attachment site [posttranslational modification]; other site 471854001346 e3 binding domain; Region: E3_binding; pfam02817 471854001347 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471854001348 competence damage-inducible protein A; Provisional; Region: PRK00549 471854001349 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 471854001350 putative MPT binding site; other site 471854001351 Competence-damaged protein; Region: CinA; pfam02464 471854001352 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 471854001353 gliding motility-associated protein GldC; Region: GldC; TIGR03515 471854001354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 471854001355 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471854001356 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 471854001357 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471854001358 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854001359 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 471854001360 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 471854001361 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 471854001362 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 471854001363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854001364 putative substrate translocation pore; other site 471854001365 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 471854001366 active site 471854001367 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 471854001368 GTP cyclohydrolase I; Provisional; Region: PLN03044 471854001369 active site 471854001370 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471854001371 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 471854001372 Cation efflux family; Region: Cation_efflux; pfam01545 471854001373 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 471854001374 ADP-ribose binding site [chemical binding]; other site 471854001375 dimer interface [polypeptide binding]; other site 471854001376 active site 471854001377 nudix motif; other site 471854001378 metal binding site [ion binding]; metal-binding site 471854001379 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 471854001380 GH3 auxin-responsive promoter; Region: GH3; pfam03321 471854001381 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 471854001382 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471854001383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854001384 Coenzyme A binding pocket [chemical binding]; other site 471854001385 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 471854001386 Sm and related proteins; Region: Sm_like; cl00259 471854001387 heptamer interface [polypeptide binding]; other site 471854001388 Sm1 motif; other site 471854001389 hexamer interface [polypeptide binding]; other site 471854001390 RNA binding site [nucleotide binding]; other site 471854001391 Sm2 motif; other site 471854001392 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 471854001393 active site residue [active] 471854001394 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 471854001395 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 471854001396 Substrate-binding site [chemical binding]; other site 471854001397 Substrate specificity [chemical binding]; other site 471854001398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 471854001399 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471854001400 Cupin domain; Region: Cupin_2; cl17218 471854001401 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471854001402 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471854001403 ligand binding site [chemical binding]; other site 471854001404 flexible hinge region; other site 471854001405 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 471854001406 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471854001407 Pectinesterase; Region: Pectinesterase; pfam01095 471854001408 putative pectinesterase; Region: PLN02432; cl01911 471854001409 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 471854001410 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 471854001411 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854001412 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471854001413 Beta-lactamase; Region: Beta-lactamase; pfam00144 471854001414 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471854001415 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471854001416 dimerization interface [polypeptide binding]; other site 471854001417 putative DNA binding site [nucleotide binding]; other site 471854001418 putative Zn2+ binding site [ion binding]; other site 471854001419 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471854001420 hydrophobic ligand binding site; other site 471854001421 DoxX-like family; Region: DoxX_2; pfam13564 471854001422 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 471854001423 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 471854001424 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 471854001425 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 471854001426 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 471854001427 Bacterial SH3 domain; Region: SH3_3; pfam08239 471854001428 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471854001429 hydrophobic ligand binding site; other site 471854001430 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 471854001431 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 471854001432 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471854001433 Serine hydrolase; Region: Ser_hydrolase; cl17834 471854001434 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854001435 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471854001436 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854001437 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854001438 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 471854001439 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854001440 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854001441 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854001442 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854001443 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854001444 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471854001445 A new structural DNA glycosylase; Region: AlkD_like; cd06561 471854001446 active site 471854001447 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471854001448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001449 active site 471854001450 phosphorylation site [posttranslational modification] 471854001451 intermolecular recognition site; other site 471854001452 dimerization interface [polypeptide binding]; other site 471854001453 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471854001454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001455 active site 471854001456 phosphorylation site [posttranslational modification] 471854001457 intermolecular recognition site; other site 471854001458 dimerization interface [polypeptide binding]; other site 471854001459 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 471854001460 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 471854001461 putative NAD(P) binding site [chemical binding]; other site 471854001462 active site 471854001463 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 471854001464 FRG domain; Region: FRG; pfam08867 471854001465 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 471854001466 proposed catalytic triad [active] 471854001467 active site nucleophile [active] 471854001468 cyanophycin synthetase; Provisional; Region: PRK14016 471854001469 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471854001470 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471854001471 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471854001472 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471854001473 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 471854001474 catalytic nucleophile [active] 471854001475 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 471854001476 dimanganese center [ion binding]; other site 471854001477 Predicted membrane protein [Function unknown]; Region: COG2323 471854001478 Predicted membrane protein [Function unknown]; Region: COG2323 471854001479 Thioredoxin; Region: Thioredoxin_5; pfam13743 471854001480 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 471854001481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 471854001482 HTH-like domain; Region: HTH_21; pfam13276 471854001483 Integrase core domain; Region: rve; pfam00665 471854001484 Integrase core domain; Region: rve_3; pfam13683 471854001485 Transposase; Region: HTH_Tnp_1; pfam01527 471854001486 Winged helix-turn helix; Region: HTH_29; pfam13551 471854001487 Helix-turn-helix domain; Region: HTH_28; pfam13518 471854001488 Homeodomain-like domain; Region: HTH_32; pfam13565 471854001489 Integrase core domain; Region: rve; pfam00665 471854001490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 471854001491 Integrase core domain; Region: rve_3; pfam13683 471854001492 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 471854001493 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854001494 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854001495 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 471854001496 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854001497 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 471854001498 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 471854001499 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854001500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854001501 ATP binding site [chemical binding]; other site 471854001502 Mg2+ binding site [ion binding]; other site 471854001503 G-X-G motif; other site 471854001504 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471854001505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001506 active site 471854001507 phosphorylation site [posttranslational modification] 471854001508 intermolecular recognition site; other site 471854001509 dimerization interface [polypeptide binding]; other site 471854001510 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854001511 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854001512 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 471854001513 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854001514 Winged helix-turn helix; Region: HTH_29; pfam13551 471854001515 Helix-turn-helix domain; Region: HTH_28; pfam13518 471854001516 Homeodomain-like domain; Region: HTH_32; pfam13565 471854001517 Integrase core domain; Region: rve; pfam00665 471854001518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 471854001519 Integrase core domain; Region: rve_3; pfam13683 471854001520 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471854001521 active site 471854001522 DNA binding site [nucleotide binding] 471854001523 Int/Topo IB signature motif; other site 471854001524 Bacterial SH3 domain homologues; Region: SH3b; smart00287 471854001525 CHRD domain; Region: CHRD; pfam07452 471854001526 helicase 45; Provisional; Region: PTZ00424 471854001527 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471854001528 ATP binding site [chemical binding]; other site 471854001529 Mg++ binding site [ion binding]; other site 471854001530 motif III; other site 471854001531 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854001532 nucleotide binding region [chemical binding]; other site 471854001533 ATP-binding site [chemical binding]; other site 471854001534 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 471854001535 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471854001536 chaperone protein DnaJ; Provisional; Region: PRK14299 471854001537 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471854001538 HSP70 interaction site [polypeptide binding]; other site 471854001539 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 471854001540 dimer interface [polypeptide binding]; other site 471854001541 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 471854001542 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854001543 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854001544 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471854001545 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854001546 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854001547 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854001548 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 471854001549 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 471854001550 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471854001551 DNA binding site [nucleotide binding] 471854001552 active site 471854001553 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 471854001554 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 471854001555 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 471854001556 dimer interface [polypeptide binding]; other site 471854001557 Citrate synthase; Region: Citrate_synt; pfam00285 471854001558 active site 471854001559 citrylCoA binding site [chemical binding]; other site 471854001560 NADH binding [chemical binding]; other site 471854001561 cationic pore residues; other site 471854001562 oxalacetate/citrate binding site [chemical binding]; other site 471854001563 coenzyme A binding site [chemical binding]; other site 471854001564 catalytic triad [active] 471854001565 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 471854001566 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 471854001567 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 471854001568 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471854001569 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471854001570 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471854001571 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471854001572 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471854001573 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 471854001574 putative DNA binding helix; other site 471854001575 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854001576 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854001577 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 471854001578 N-terminal plug; other site 471854001579 ligand-binding site [chemical binding]; other site 471854001580 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 471854001581 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 471854001582 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854001583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854001584 dimer interface [polypeptide binding]; other site 471854001585 phosphorylation site [posttranslational modification] 471854001586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854001587 ATP binding site [chemical binding]; other site 471854001588 Mg2+ binding site [ion binding]; other site 471854001589 G-X-G motif; other site 471854001590 Response regulator receiver domain; Region: Response_reg; pfam00072 471854001591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001592 active site 471854001593 phosphorylation site [posttranslational modification] 471854001594 intermolecular recognition site; other site 471854001595 dimerization interface [polypeptide binding]; other site 471854001596 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471854001597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854001598 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854001599 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854001600 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854001601 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854001602 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854001603 SusD family; Region: SusD; pfam07980 471854001604 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471854001605 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 471854001606 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 471854001607 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471854001608 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471854001609 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 471854001610 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471854001611 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854001612 YCII-related domain; Region: YCII; cl00999 471854001613 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 471854001614 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 471854001615 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854001616 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 471854001617 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 471854001618 Caspase domain; Region: Peptidase_C14; pfam00656 471854001619 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 471854001620 active site 471854001621 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 471854001622 Caspase domain; Region: Peptidase_C14; pfam00656 471854001623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854001624 Coenzyme A binding pocket [chemical binding]; other site 471854001625 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471854001626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001627 active site 471854001628 phosphorylation site [posttranslational modification] 471854001629 intermolecular recognition site; other site 471854001630 dimerization interface [polypeptide binding]; other site 471854001631 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471854001632 DNA binding site [nucleotide binding] 471854001633 Outer membrane efflux protein; Region: OEP; pfam02321 471854001634 Outer membrane efflux protein; Region: OEP; pfam02321 471854001635 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854001636 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854001637 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854001638 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 471854001639 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854001640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001641 active site 471854001642 phosphorylation site [posttranslational modification] 471854001643 intermolecular recognition site; other site 471854001644 dimerization interface [polypeptide binding]; other site 471854001645 LytTr DNA-binding domain; Region: LytTR; smart00850 471854001646 galactonate dehydratase; Provisional; Region: PRK14017 471854001647 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 471854001648 putative active site pocket [active] 471854001649 putative metal binding site [ion binding]; other site 471854001650 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 471854001651 putative lipid binding site [chemical binding]; other site 471854001652 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 471854001653 nudix motif; other site 471854001654 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 471854001655 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854001656 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 471854001657 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854001658 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854001659 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854001660 DNA binding residues [nucleotide binding] 471854001661 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854001662 FecR protein; Region: FecR; pfam04773 471854001663 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854001664 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854001665 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854001666 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854001667 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854001668 D-mannonate dehydratase (UxuA); Region: UxuA; pfam03786 471854001669 mannonate dehydratase; Region: uxuA; TIGR00695 471854001670 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854001671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001672 active site 471854001673 phosphorylation site [posttranslational modification] 471854001674 intermolecular recognition site; other site 471854001675 dimerization interface [polypeptide binding]; other site 471854001676 LytTr DNA-binding domain; Region: LytTR; smart00850 471854001677 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471854001678 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 471854001679 Histidine kinase; Region: His_kinase; pfam06580 471854001680 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854001681 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854001682 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854001683 DNA binding residues [nucleotide binding] 471854001684 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854001685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001686 active site 471854001687 phosphorylation site [posttranslational modification] 471854001688 intermolecular recognition site; other site 471854001689 dimerization interface [polypeptide binding]; other site 471854001690 LytTr DNA-binding domain; Region: LytTR; smart00850 471854001691 Histidine kinase; Region: His_kinase; pfam06580 471854001692 Histidine kinase; Region: His_kinase; pfam06580 471854001693 LytTr DNA-binding domain; Region: LytTR; smart00850 471854001694 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 471854001695 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 471854001696 dimer interface [polypeptide binding]; other site 471854001697 active site 471854001698 CoA binding pocket [chemical binding]; other site 471854001699 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 471854001700 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471854001701 ligand binding site [chemical binding]; other site 471854001702 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854001703 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 471854001704 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854001705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001706 active site 471854001707 phosphorylation site [posttranslational modification] 471854001708 intermolecular recognition site; other site 471854001709 dimerization interface [polypeptide binding]; other site 471854001710 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854001711 DNA binding residues [nucleotide binding] 471854001712 dimerization interface [polypeptide binding]; other site 471854001713 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 471854001714 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854001715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854001716 ATP binding site [chemical binding]; other site 471854001717 Mg2+ binding site [ion binding]; other site 471854001718 G-X-G motif; other site 471854001719 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 471854001720 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 471854001721 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 471854001722 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854001723 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854001724 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854001725 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854001726 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854001727 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854001728 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854001729 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854001730 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854001731 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854001732 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854001733 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 471854001734 active site 471854001735 catalytic triad [active] 471854001736 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 471854001737 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854001738 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471854001739 Beta-lactamase; Region: Beta-lactamase; pfam00144 471854001740 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 471854001741 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 471854001742 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 471854001743 dimer interface [polypeptide binding]; other site 471854001744 active site 471854001745 heme binding site [chemical binding]; other site 471854001746 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 471854001747 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 471854001748 trehalose synthase; Region: treS_nterm; TIGR02456 471854001749 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 471854001750 active site 471854001751 catalytic site [active] 471854001752 Predicted membrane protein [Function unknown]; Region: COG2323 471854001753 Predicted membrane protein [Function unknown]; Region: COG2323 471854001754 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 471854001755 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471854001756 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854001757 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854001758 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471854001759 Ferritin-like; Region: Ferritin-like; pfam12902 471854001760 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854001761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854001762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 471854001763 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 471854001764 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 471854001765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 471854001766 Trehalase; Region: Trehalase; cl17346 471854001767 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 471854001768 active site 471854001769 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854001770 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854001771 SusD family; Region: SusD; pfam07980 471854001772 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854001773 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854001774 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854001775 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854001776 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854001777 FecR protein; Region: FecR; pfam04773 471854001778 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854001779 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854001780 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854001781 DNA binding residues [nucleotide binding] 471854001782 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471854001783 MarR family; Region: MarR_2; cl17246 471854001784 phosphoenolpyruvate synthase; Validated; Region: PRK06241 471854001785 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 471854001786 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 471854001787 Predicted integral membrane protein [Function unknown]; Region: COG5616 471854001788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854001789 binding surface 471854001790 TPR motif; other site 471854001791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854001792 binding surface 471854001793 TPR motif; other site 471854001794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 471854001795 TPR motif; other site 471854001796 binding surface 471854001797 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 471854001798 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 471854001799 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 471854001800 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 471854001801 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 471854001802 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 471854001803 active site 471854001804 catalytic site [active] 471854001805 SPW repeat; Region: SPW; pfam03779 471854001806 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 471854001807 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 471854001808 putative substrate binding site [chemical binding]; other site 471854001809 active site 471854001810 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854001811 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 471854001812 active site 471854001813 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471854001814 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 471854001815 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471854001816 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854001817 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 471854001818 active site triad [active] 471854001819 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 471854001820 active site 471854001821 catalytic triad [active] 471854001822 oxyanion hole [active] 471854001823 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 471854001824 HEAT repeats; Region: HEAT_2; pfam13646 471854001825 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 471854001826 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 471854001827 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 471854001828 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854001829 FtsX-like permease family; Region: FtsX; pfam02687 471854001830 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854001831 FtsX-like permease family; Region: FtsX; pfam02687 471854001832 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471854001833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854001834 Walker A motif; other site 471854001835 ATP binding site [chemical binding]; other site 471854001836 Walker B motif; other site 471854001837 arginine finger; other site 471854001838 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 471854001839 TPR repeat; Region: TPR_11; pfam13414 471854001840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854001841 binding surface 471854001842 TPR motif; other site 471854001843 TPR repeat; Region: TPR_11; pfam13414 471854001844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854001845 binding surface 471854001846 TPR motif; other site 471854001847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854001848 binding surface 471854001849 Tetratricopeptide repeat; Region: TPR_16; pfam13432 471854001850 TPR motif; other site 471854001851 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 471854001852 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 471854001853 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 471854001854 Phage protein D [General function prediction only]; Region: COG3500 471854001855 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 471854001856 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 471854001857 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 471854001858 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 471854001859 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 471854001860 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 471854001861 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 471854001862 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 471854001863 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854001864 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854001865 DNA binding residues [nucleotide binding] 471854001866 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854001867 FecR protein; Region: FecR; pfam04773 471854001868 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854001869 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854001870 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854001871 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854001872 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854001873 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854001874 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854001875 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 471854001876 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 471854001877 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471854001878 Walker A/P-loop; other site 471854001879 ATP binding site [chemical binding]; other site 471854001880 Q-loop/lid; other site 471854001881 ABC transporter signature motif; other site 471854001882 Walker B; other site 471854001883 D-loop; other site 471854001884 H-loop/switch region; other site 471854001885 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 471854001886 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 471854001887 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 471854001888 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854001889 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854001890 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854001891 DNA binding residues [nucleotide binding] 471854001892 Domain of unknown function (DUF4374); Region: DUF4374; pfam14298 471854001893 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 471854001894 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 471854001895 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854001896 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854001897 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 471854001898 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471854001899 ligand binding site [chemical binding]; other site 471854001900 flexible hinge region; other site 471854001901 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 471854001902 putative switch regulator; other site 471854001903 non-specific DNA interactions [nucleotide binding]; other site 471854001904 DNA binding site [nucleotide binding] 471854001905 sequence specific DNA binding site [nucleotide binding]; other site 471854001906 putative cAMP binding site [chemical binding]; other site 471854001907 Cytochrome c; Region: Cytochrom_C; pfam00034 471854001908 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 471854001909 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 471854001910 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 471854001911 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 471854001912 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 471854001913 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 471854001914 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471854001915 Walker A/P-loop; other site 471854001916 ATP binding site [chemical binding]; other site 471854001917 Q-loop/lid; other site 471854001918 ABC transporter signature motif; other site 471854001919 Walker B; other site 471854001920 D-loop; other site 471854001921 H-loop/switch region; other site 471854001922 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 471854001923 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 471854001924 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 471854001925 Hemerythrin-like domain; Region: Hr-like; cd12108 471854001926 Fe binding site [ion binding]; other site 471854001927 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 471854001928 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 471854001929 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 471854001930 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 471854001931 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471854001932 Ligand Binding Site [chemical binding]; other site 471854001933 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471854001934 Ligand Binding Site [chemical binding]; other site 471854001935 maltose O-acetyltransferase; Provisional; Region: PRK10092 471854001936 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 471854001937 active site 471854001938 substrate binding site [chemical binding]; other site 471854001939 trimer interface [polypeptide binding]; other site 471854001940 CoA binding site [chemical binding]; other site 471854001941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854001942 Walker A/P-loop; other site 471854001943 ATP binding site [chemical binding]; other site 471854001944 Q-loop/lid; other site 471854001945 ABC transporter signature motif; other site 471854001946 Walker B; other site 471854001947 D-loop; other site 471854001948 H-loop/switch region; other site 471854001949 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471854001950 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471854001951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854001952 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 471854001953 Walker A/P-loop; other site 471854001954 ATP binding site [chemical binding]; other site 471854001955 Q-loop/lid; other site 471854001956 ABC transporter signature motif; other site 471854001957 Walker B; other site 471854001958 D-loop; other site 471854001959 H-loop/switch region; other site 471854001960 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 471854001961 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471854001962 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854001963 Outer membrane efflux protein; Region: OEP; pfam02321 471854001964 Outer membrane efflux protein; Region: OEP; pfam02321 471854001965 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471854001966 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854001967 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854001968 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854001969 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854001970 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854001971 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854001972 FecR protein; Region: FecR; pfam04773 471854001973 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854001974 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854001975 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854001976 DNA binding residues [nucleotide binding] 471854001977 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854001978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854001979 dimer interface [polypeptide binding]; other site 471854001980 phosphorylation site [posttranslational modification] 471854001981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854001982 ATP binding site [chemical binding]; other site 471854001983 Mg2+ binding site [ion binding]; other site 471854001984 G-X-G motif; other site 471854001985 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 471854001986 active site 471854001987 catalytic triad [active] 471854001988 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 471854001989 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854001990 Histidine kinase; Region: HisKA_3; pfam07730 471854001991 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471854001992 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854001993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854001994 active site 471854001995 phosphorylation site [posttranslational modification] 471854001996 intermolecular recognition site; other site 471854001997 dimerization interface [polypeptide binding]; other site 471854001998 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854001999 DNA binding residues [nucleotide binding] 471854002000 dimerization interface [polypeptide binding]; other site 471854002001 Right handed beta helix region; Region: Beta_helix; pfam13229 471854002002 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854002003 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854002004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854002005 active site 471854002006 phosphorylation site [posttranslational modification] 471854002007 intermolecular recognition site; other site 471854002008 dimerization interface [polypeptide binding]; other site 471854002009 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854002010 DNA binding residues [nucleotide binding] 471854002011 dimerization interface [polypeptide binding]; other site 471854002012 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 471854002013 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471854002014 Histidine kinase; Region: HisKA_3; pfam07730 471854002015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854002016 ATP binding site [chemical binding]; other site 471854002017 Mg2+ binding site [ion binding]; other site 471854002018 G-X-G motif; other site 471854002019 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854002020 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 471854002021 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471854002022 catalytic loop [active] 471854002023 iron binding site [ion binding]; other site 471854002024 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 471854002025 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 471854002026 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 471854002027 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471854002028 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471854002029 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854002030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854002031 active site 471854002032 phosphorylation site [posttranslational modification] 471854002033 intermolecular recognition site; other site 471854002034 dimerization interface [polypeptide binding]; other site 471854002035 LytTr DNA-binding domain; Region: LytTR; smart00850 471854002036 Histidine kinase; Region: His_kinase; pfam06580 471854002037 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471854002038 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471854002039 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 471854002040 Predicted transcriptional regulators [Transcription]; Region: COG1733 471854002041 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471854002042 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 471854002043 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 471854002044 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471854002045 NAD binding site [chemical binding]; other site 471854002046 active site 471854002047 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471854002048 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471854002049 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471854002050 ABC transporter; Region: ABC_tran_2; pfam12848 471854002051 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471854002052 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 471854002053 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 471854002054 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 471854002055 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 471854002056 active site 471854002057 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 471854002058 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854002059 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854002060 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854002061 DNA binding residues [nucleotide binding] 471854002062 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471854002063 homotrimer interaction site [polypeptide binding]; other site 471854002064 putative active site [active] 471854002065 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471854002066 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471854002067 DNA-binding site [nucleotide binding]; DNA binding site 471854002068 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471854002069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854002070 homodimer interface [polypeptide binding]; other site 471854002071 catalytic residue [active] 471854002072 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 471854002073 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 471854002074 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 471854002075 short chain dehydrogenase; Provisional; Region: PRK06123 471854002076 classical (c) SDRs; Region: SDR_c; cd05233 471854002077 NAD(P) binding site [chemical binding]; other site 471854002078 active site 471854002079 Protein of unknown function DUF72; Region: DUF72; pfam01904 471854002080 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471854002081 RibD C-terminal domain; Region: RibD_C; cl17279 471854002082 YCII-related domain; Region: YCII; cl00999 471854002083 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471854002084 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854002085 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471854002086 DNA binding residues [nucleotide binding] 471854002087 Histidine kinase; Region: His_kinase; pfam06580 471854002088 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854002089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854002090 active site 471854002091 phosphorylation site [posttranslational modification] 471854002092 intermolecular recognition site; other site 471854002093 dimerization interface [polypeptide binding]; other site 471854002094 LytTr DNA-binding domain; Region: LytTR; smart00850 471854002095 Cytochrome c; Region: Cytochrom_C; pfam00034 471854002096 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471854002097 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 471854002098 nucleophilic elbow; other site 471854002099 catalytic triad; other site 471854002100 PQQ-like domain; Region: PQQ_2; pfam13360 471854002101 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 471854002102 Trp docking motif [polypeptide binding]; other site 471854002103 active site 471854002104 PQQ-like domain; Region: PQQ_2; pfam13360 471854002105 Histidine kinase; Region: His_kinase; pfam06580 471854002106 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854002107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854002108 active site 471854002109 phosphorylation site [posttranslational modification] 471854002110 intermolecular recognition site; other site 471854002111 dimerization interface [polypeptide binding]; other site 471854002112 LytTr DNA-binding domain; Region: LytTR; smart00850 471854002113 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 471854002114 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 471854002115 putative NAD(P) binding site [chemical binding]; other site 471854002116 putative substrate binding site [chemical binding]; other site 471854002117 catalytic Zn binding site [ion binding]; other site 471854002118 structural Zn binding site [ion binding]; other site 471854002119 dimer interface [polypeptide binding]; other site 471854002120 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 471854002121 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 471854002122 putative trimer interface [polypeptide binding]; other site 471854002123 putative CoA binding site [chemical binding]; other site 471854002124 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 471854002125 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854002126 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854002127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854002128 NAD(P) binding site [chemical binding]; other site 471854002129 active site 471854002130 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854002131 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854002132 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854002133 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854002134 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854002135 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854002136 fec operon regulator FecR; Reviewed; Region: PRK09774 471854002137 FecR protein; Region: FecR; pfam04773 471854002138 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854002139 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854002140 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471854002141 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471854002142 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471854002143 ligand binding site [chemical binding]; other site 471854002144 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 471854002145 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 471854002146 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 471854002147 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 471854002148 Penicillinase repressor; Region: Pencillinase_R; pfam03965 471854002149 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 471854002150 dimerization interface [polypeptide binding]; other site 471854002151 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 471854002152 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 471854002153 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471854002154 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 471854002155 GAF domain; Region: GAF; pfam01590 471854002156 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471854002157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854002158 ATP binding site [chemical binding]; other site 471854002159 Mg2+ binding site [ion binding]; other site 471854002160 G-X-G motif; other site 471854002161 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 471854002162 Two component regulator propeller; Region: Reg_prop; pfam07494 471854002163 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 471854002164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854002165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854002166 dimer interface [polypeptide binding]; other site 471854002167 phosphorylation site [posttranslational modification] 471854002168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854002169 ATP binding site [chemical binding]; other site 471854002170 Mg2+ binding site [ion binding]; other site 471854002171 G-X-G motif; other site 471854002172 Response regulator receiver domain; Region: Response_reg; pfam00072 471854002173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854002174 active site 471854002175 phosphorylation site [posttranslational modification] 471854002176 intermolecular recognition site; other site 471854002177 dimerization interface [polypeptide binding]; other site 471854002178 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854002179 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854002180 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854002181 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854002182 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854002183 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854002184 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854002185 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854002186 SusD family; Region: SusD; pfam07980 471854002187 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 471854002188 substrate binding site [chemical binding]; other site 471854002189 active site 471854002190 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 471854002191 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 471854002192 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 471854002193 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 471854002194 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471854002195 Sulfatase; Region: Sulfatase; pfam00884 471854002196 Histidine kinase; Region: His_kinase; pfam06580 471854002197 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854002198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854002199 active site 471854002200 phosphorylation site [posttranslational modification] 471854002201 intermolecular recognition site; other site 471854002202 dimerization interface [polypeptide binding]; other site 471854002203 LytTr DNA-binding domain; Region: LytTR; pfam04397 471854002204 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 471854002205 SnoaL-like domain; Region: SnoaL_2; pfam12680 471854002206 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471854002207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471854002208 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854002209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854002210 active site 471854002211 phosphorylation site [posttranslational modification] 471854002212 intermolecular recognition site; other site 471854002213 dimerization interface [polypeptide binding]; other site 471854002214 LytTr DNA-binding domain; Region: LytTR; smart00850 471854002215 Histidine kinase; Region: His_kinase; pfam06580 471854002216 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854002217 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854002218 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854002219 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 471854002220 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 471854002221 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 471854002222 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854002223 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854002224 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854002225 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854002226 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854002227 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854002228 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 471854002229 Two component regulator propeller; Region: Reg_prop; pfam07494 471854002230 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471854002231 Interdomain contacts; other site 471854002232 Cytokine receptor motif; other site 471854002233 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854002234 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854002235 dimer interface [polypeptide binding]; other site 471854002236 phosphorylation site [posttranslational modification] 471854002237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854002238 ATP binding site [chemical binding]; other site 471854002239 Mg2+ binding site [ion binding]; other site 471854002240 G-X-G motif; other site 471854002241 Response regulator receiver domain; Region: Response_reg; pfam00072 471854002242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854002243 active site 471854002244 phosphorylation site [posttranslational modification] 471854002245 intermolecular recognition site; other site 471854002246 dimerization interface [polypeptide binding]; other site 471854002247 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854002248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854002249 DoxX-like family; Region: DoxX_2; pfam13564 471854002250 SnoaL-like domain; Region: SnoaL_2; pfam12680 471854002251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854002252 non-specific DNA binding site [nucleotide binding]; other site 471854002253 salt bridge; other site 471854002254 sequence-specific DNA binding site [nucleotide binding]; other site 471854002255 Catalytic domain of uncharacterized hypothetical proteins similar to eukaryotic phosphatidylinositol-specific phospholipase C, X domain containing proteins; Region: PI-PLCXDc_like_2; cd08621 471854002256 putative active site [active] 471854002257 catalytic site [active] 471854002258 Right handed beta helix region; Region: Beta_helix; pfam13229 471854002259 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 471854002260 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854002261 Predicted peptidase [General function prediction only]; Region: COG4099 471854002262 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 471854002263 substrate binding site [chemical binding]; other site 471854002264 active site 471854002265 RibD C-terminal domain; Region: RibD_C; cl17279 471854002266 Trehalose utilisation; Region: ThuA; pfam06283 471854002267 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 471854002268 sugar binding site [chemical binding]; other site 471854002269 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 471854002270 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471854002271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854002272 Coenzyme A binding pocket [chemical binding]; other site 471854002273 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471854002274 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854002275 active site 471854002276 Predicted integral membrane protein [Function unknown]; Region: COG5637 471854002277 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 471854002278 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 471854002279 putative hydrophobic ligand binding site [chemical binding]; other site 471854002280 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 471854002281 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471854002282 NAD binding site [chemical binding]; other site 471854002283 catalytic Zn binding site [ion binding]; other site 471854002284 structural Zn binding site [ion binding]; other site 471854002285 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 471854002286 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 471854002287 putative dimer interface [polypeptide binding]; other site 471854002288 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471854002289 active site 471854002290 NTP binding site [chemical binding]; other site 471854002291 metal binding triad [ion binding]; metal-binding site 471854002292 antibiotic binding site [chemical binding]; other site 471854002293 HEPN domain; Region: HEPN; cl00824 471854002294 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471854002295 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471854002296 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 471854002297 AAA domain; Region: AAA_21; pfam13304 471854002298 short chain dehydrogenase; Provisional; Region: PRK05854 471854002299 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 471854002300 putative NAD(P) binding site [chemical binding]; other site 471854002301 active site 471854002302 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854002303 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854002304 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 471854002305 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 471854002306 Chromate transporter; Region: Chromate_transp; pfam02417 471854002307 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 471854002308 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 471854002309 arsenical-resistance protein; Region: acr3; TIGR00832 471854002310 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 471854002311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854002312 Coenzyme A binding pocket [chemical binding]; other site 471854002313 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471854002314 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 471854002315 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471854002316 active site 471854002317 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471854002318 dimerization interface [polypeptide binding]; other site 471854002319 putative DNA binding site [nucleotide binding]; other site 471854002320 putative Zn2+ binding site [ion binding]; other site 471854002321 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471854002322 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 471854002323 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 471854002324 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471854002325 substrate binding site [chemical binding]; other site 471854002326 activation loop (A-loop); other site 471854002327 AAA ATPase domain; Region: AAA_16; pfam13191 471854002328 Predicted ATPase [General function prediction only]; Region: COG3899 471854002329 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471854002330 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 471854002331 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854002332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854002333 dimer interface [polypeptide binding]; other site 471854002334 phosphorylation site [posttranslational modification] 471854002335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854002336 ATP binding site [chemical binding]; other site 471854002337 Mg2+ binding site [ion binding]; other site 471854002338 G-X-G motif; other site 471854002339 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471854002340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854002341 active site 471854002342 phosphorylation site [posttranslational modification] 471854002343 intermolecular recognition site; other site 471854002344 dimerization interface [polypeptide binding]; other site 471854002345 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 471854002346 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471854002347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854002348 active site 471854002349 phosphorylation site [posttranslational modification] 471854002350 intermolecular recognition site; other site 471854002351 dimerization interface [polypeptide binding]; other site 471854002352 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471854002353 DNA binding site [nucleotide binding] 471854002354 Histidine kinase; Region: His_kinase; pfam06580 471854002355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854002356 active site 471854002357 phosphorylation site [posttranslational modification] 471854002358 intermolecular recognition site; other site 471854002359 dimerization interface [polypeptide binding]; other site 471854002360 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 471854002361 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 471854002362 putative acyl-acceptor binding pocket; other site 471854002363 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 471854002364 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 471854002365 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 471854002366 Spi protease inhibitor; Region: Inhibitor_I69; pfam13734 471854002367 Peptidase C10 family; Region: Peptidase_C10; pfam01640 471854002368 Transposase; Region: HTH_Tnp_1; cl17663 471854002369 putative transposase OrfB; Reviewed; Region: PHA02517 471854002370 HTH-like domain; Region: HTH_21; pfam13276 471854002371 Integrase core domain; Region: rve; pfam00665 471854002372 Integrase core domain; Region: rve_3; pfam13683 471854002373 putative transposase OrfB; Reviewed; Region: PHA02517 471854002374 HTH-like domain; Region: HTH_21; pfam13276 471854002375 Integrase core domain; Region: rve; pfam00665 471854002376 Integrase core domain; Region: rve_3; pfam13683 471854002377 Transposase; Region: HTH_Tnp_1; cl17663 471854002378 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854002379 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854002380 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471854002381 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471854002382 Poxvirus DNA dependent RNA polymerase 30kDa subunit; Region: rpo30_N; pfam12410 471854002383 SnoaL-like domain; Region: SnoaL_2; pfam12680 471854002384 short chain dehydrogenase; Provisional; Region: PRK06523 471854002385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854002386 NAD(P) binding site [chemical binding]; other site 471854002387 active site 471854002388 Predicted transcriptional regulators [Transcription]; Region: COG1733 471854002389 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471854002390 peptide synthase; Provisional; Region: PRK12467 471854002391 Transposase; Region: HTH_Tnp_1; pfam01527 471854002392 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 471854002393 HTH-like domain; Region: HTH_21; pfam13276 471854002394 Integrase core domain; Region: rve; pfam00665 471854002395 Integrase core domain; Region: rve_3; pfam13683 471854002396 Antirestriction protein (ArdA); Region: ArdA; pfam07275 471854002397 Helix-turn-helix domain; Region: HTH_17; pfam12728 471854002398 PQQ-like domain; Region: PQQ_2; pfam13360 471854002399 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 471854002400 active site 471854002401 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471854002402 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471854002403 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471854002404 ligand binding site [chemical binding]; other site 471854002405 flexible hinge region; other site 471854002406 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471854002407 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 471854002408 active site 471854002409 DNA binding site [nucleotide binding] 471854002410 Int/Topo IB signature motif; other site 471854002411 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 471854002412 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 471854002413 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 471854002414 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 471854002415 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 471854002416 DNA-binding site [nucleotide binding]; DNA binding site 471854002417 RNA-binding motif; other site 471854002418 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854002419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854002420 DNA binding residues [nucleotide binding] 471854002421 dimerization interface [polypeptide binding]; other site 471854002422 Fatty acid desaturase; Region: FA_desaturase; pfam00487 471854002423 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 471854002424 putative di-iron ligands [ion binding]; other site 471854002425 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 471854002426 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471854002427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854002428 putative active site [active] 471854002429 heme pocket [chemical binding]; other site 471854002430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854002431 dimer interface [polypeptide binding]; other site 471854002432 phosphorylation site [posttranslational modification] 471854002433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854002434 ATP binding site [chemical binding]; other site 471854002435 Mg2+ binding site [ion binding]; other site 471854002436 G-X-G motif; other site 471854002437 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854002438 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854002439 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471854002440 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 471854002441 NADP binding site [chemical binding]; other site 471854002442 putative substrate binding site [chemical binding]; other site 471854002443 active site 471854002444 short chain dehydrogenase; Provisional; Region: PRK06197 471854002445 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 471854002446 putative NAD(P) binding site [chemical binding]; other site 471854002447 active site 471854002448 GAF domain; Region: GAF; pfam01590 471854002449 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 471854002450 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854002451 ATP binding site [chemical binding]; other site 471854002452 Walker B motif; other site 471854002453 arginine finger; other site 471854002454 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 471854002455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854002456 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471854002457 NAD(P) binding site [chemical binding]; other site 471854002458 active site 471854002459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854002460 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471854002461 NAD(P) binding site [chemical binding]; other site 471854002462 active site 471854002463 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471854002464 dimerization interface [polypeptide binding]; other site 471854002465 putative DNA binding site [nucleotide binding]; other site 471854002466 putative Zn2+ binding site [ion binding]; other site 471854002467 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 471854002468 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471854002469 active site 471854002470 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 471854002471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854002472 Coenzyme A binding pocket [chemical binding]; other site 471854002473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471854002474 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 471854002475 arsenical-resistance protein; Region: acr3; TIGR00832 471854002476 CHC2 zinc finger; Region: zf-CHC2; cl17510 471854002477 Toprim-like; Region: Toprim_2; pfam13155 471854002478 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 471854002479 putative catalytic site [active] 471854002480 putative phosphate binding site [ion binding]; other site 471854002481 active site 471854002482 metal binding site A [ion binding]; metal-binding site 471854002483 DNA binding site [nucleotide binding] 471854002484 putative AP binding site [nucleotide binding]; other site 471854002485 putative metal binding site B [ion binding]; other site 471854002486 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471854002487 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854002488 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 471854002489 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 471854002490 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471854002491 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 471854002492 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 471854002493 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 471854002494 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 471854002495 putative dimer interface [polypeptide binding]; other site 471854002496 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854002497 oxidoreductase; Provisional; Region: PRK06196 471854002498 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 471854002499 putative NAD(P) binding site [chemical binding]; other site 471854002500 active site 471854002501 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854002502 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854002503 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 471854002504 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 471854002505 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 471854002506 non-specific DNA binding site [nucleotide binding]; other site 471854002507 salt bridge; other site 471854002508 sequence-specific DNA binding site [nucleotide binding]; other site 471854002509 AAA domain; Region: AAA_21; pfam13304 471854002510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854002511 Walker A/P-loop; other site 471854002512 ATP binding site [chemical binding]; other site 471854002513 TIGR02646 family protein; Region: TIGR02646 471854002514 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471854002515 Part of AAA domain; Region: AAA_19; pfam13245 471854002516 Family description; Region: UvrD_C_2; pfam13538 471854002517 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 471854002518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471854002519 Domain of unknown function (DUF4134); Region: DUF4134; pfam13572 471854002520 Domain of unknown function (DUF4133); Region: DUF4133; pfam13571 471854002521 Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782 471854002522 Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781 471854002523 Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779 471854002524 Protein of unknown function (DUF3714); Region: DUF3714; pfam12508 471854002525 Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780 471854002526 Domain of unknown function (DUF4138); Region: DUF4138; pfam13595 471854002527 Helix-turn-helix domain; Region: HTH_17; pfam12728 471854002528 Domain of unknown function (DUF932); Region: DUF932; pfam06067 471854002529 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 471854002530 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 471854002531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854002532 binding surface 471854002533 TPR motif; other site 471854002534 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 471854002535 Int/Topo IB signature motif; other site 471854002536 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471854002537 catalytic triad [active] 471854002538 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 471854002539 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471854002540 Domain of unknown function DUF87; Region: DUF87; pfam01935 471854002541 AAA-like domain; Region: AAA_10; pfam12846 471854002542 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 471854002543 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 471854002544 cyclase homology domain; Region: CHD; cd07302 471854002545 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 471854002546 nucleotidyl binding site; other site 471854002547 metal binding site [ion binding]; metal-binding site 471854002548 dimer interface [polypeptide binding]; other site 471854002549 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471854002550 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 471854002551 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 471854002552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854002553 non-specific DNA binding site [nucleotide binding]; other site 471854002554 salt bridge; other site 471854002555 sequence-specific DNA binding site [nucleotide binding]; other site 471854002556 Helix-turn-helix domain; Region: HTH_17; pfam12728 471854002557 DNA-sulfur modification-associated; Region: DndB; pfam14072 471854002558 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471854002559 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 471854002560 active site 471854002561 DNA binding site [nucleotide binding] 471854002562 Int/Topo IB signature motif; other site 471854002563 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854002564 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 471854002565 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 471854002566 N-terminal plug; other site 471854002567 ligand-binding site [chemical binding]; other site 471854002568 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854002569 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854002570 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854002571 DNA binding residues [nucleotide binding] 471854002572 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 471854002573 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 471854002574 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854002575 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471854002576 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471854002577 active site 471854002578 metal binding site [ion binding]; metal-binding site 471854002579 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 471854002580 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 471854002581 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854002582 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854002583 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854002584 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854002585 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854002586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854002587 NmrA-like family; Region: NmrA; pfam05368 471854002588 NAD(P) binding site [chemical binding]; other site 471854002589 active site 471854002590 MutS domain III; Region: MutS_III; pfam05192 471854002591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854002592 Walker A/P-loop; other site 471854002593 ATP binding site [chemical binding]; other site 471854002594 Q-loop/lid; other site 471854002595 ABC transporter signature motif; other site 471854002596 Walker B; other site 471854002597 D-loop; other site 471854002598 H-loop/switch region; other site 471854002599 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854002600 PAS domain; Region: PAS_9; pfam13426 471854002601 putative active site [active] 471854002602 heme pocket [chemical binding]; other site 471854002603 PAS domain S-box; Region: sensory_box; TIGR00229 471854002604 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854002605 PAS fold; Region: PAS_3; pfam08447 471854002606 putative active site [active] 471854002607 heme pocket [chemical binding]; other site 471854002608 GAF domain; Region: GAF_2; pfam13185 471854002609 GAF domain; Region: GAF; pfam01590 471854002610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854002611 PAS fold; Region: PAS_3; pfam08447 471854002612 putative active site [active] 471854002613 heme pocket [chemical binding]; other site 471854002614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854002615 phosphorylation site [posttranslational modification] 471854002616 dimer interface [polypeptide binding]; other site 471854002617 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471854002618 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471854002619 active site 471854002620 metal binding site [ion binding]; metal-binding site 471854002621 hypothetical protein; Provisional; Region: PRK11281 471854002622 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 471854002623 Outer membrane efflux protein; Region: OEP; pfam02321 471854002624 Outer membrane efflux protein; Region: OEP; pfam02321 471854002625 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854002626 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854002627 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471854002628 Sulfatase; Region: Sulfatase; pfam00884 471854002629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471854002630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471854002631 WHG domain; Region: WHG; pfam13305 471854002632 Outer membrane efflux protein; Region: OEP; pfam02321 471854002633 Outer membrane efflux protein; Region: OEP; pfam02321 471854002634 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854002635 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854002636 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854002637 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 471854002638 Protein export membrane protein; Region: SecD_SecF; cl14618 471854002639 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854002640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854002641 active site 471854002642 phosphorylation site [posttranslational modification] 471854002643 intermolecular recognition site; other site 471854002644 dimerization interface [polypeptide binding]; other site 471854002645 LytTr DNA-binding domain; Region: LytTR; smart00850 471854002646 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854002647 Histidine kinase; Region: His_kinase; pfam06580 471854002648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854002649 ATP binding site [chemical binding]; other site 471854002650 Mg2+ binding site [ion binding]; other site 471854002651 G-X-G motif; other site 471854002652 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854002653 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854002654 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854002655 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854002656 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 471854002657 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854002658 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 471854002659 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 471854002660 metal binding site [ion binding]; metal-binding site 471854002661 substrate binding pocket [chemical binding]; other site 471854002662 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471854002663 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471854002664 DNA binding site [nucleotide binding] 471854002665 domain linker motif; other site 471854002666 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471854002667 dimerization interface [polypeptide binding]; other site 471854002668 ligand binding site [chemical binding]; other site 471854002669 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 471854002670 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471854002671 active site pocket [active] 471854002672 galactonate dehydratase; Provisional; Region: PRK14017 471854002673 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 471854002674 metal binding site [ion binding]; metal-binding site 471854002675 substrate binding pocket [chemical binding]; other site 471854002676 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854002677 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854002678 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854002679 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854002680 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854002681 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854002682 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 471854002683 PQQ-like domain; Region: PQQ_2; pfam13360 471854002684 Trp docking motif [polypeptide binding]; other site 471854002685 putative active site [active] 471854002686 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471854002687 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 471854002688 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 471854002689 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 471854002690 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 471854002691 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 471854002692 active site 471854002693 intersubunit interface [polypeptide binding]; other site 471854002694 catalytic residue [active] 471854002695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854002696 D-galactonate transporter; Region: 2A0114; TIGR00893 471854002697 putative substrate translocation pore; other site 471854002698 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471854002699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854002700 Coenzyme A binding pocket [chemical binding]; other site 471854002701 Predicted transcriptional regulators [Transcription]; Region: COG1733 471854002702 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471854002703 short chain dehydrogenase; Validated; Region: PRK06182 471854002704 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 471854002705 NADP binding site [chemical binding]; other site 471854002706 active site 471854002707 steroid binding site; other site 471854002708 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 471854002709 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 471854002710 active site 471854002711 homotetramer interface [polypeptide binding]; other site 471854002712 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 471854002713 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471854002714 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471854002715 ligand binding site [chemical binding]; other site 471854002716 flexible hinge region; other site 471854002717 DinB superfamily; Region: DinB_2; pfam12867 471854002718 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854002719 active site 471854002720 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 471854002721 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme D-Threonine Aldolase; Region: PLPDE_III_D-TA; cd06821 471854002722 dimer interface [polypeptide binding]; other site 471854002723 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 471854002724 active site 471854002725 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471854002726 substrate binding site [chemical binding]; other site 471854002727 catalytic residue [active] 471854002728 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 471854002729 homotrimer interaction site [polypeptide binding]; other site 471854002730 putative active site [active] 471854002731 GntP family permease; Region: GntP_permease; pfam02447 471854002732 fructuronate transporter; Provisional; Region: PRK10034; cl15264 471854002733 DNA gyrase subunit A; Validated; Region: PRK05560 471854002734 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 471854002735 CAP-like domain; other site 471854002736 active site 471854002737 primary dimer interface [polypeptide binding]; other site 471854002738 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471854002739 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471854002740 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471854002741 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471854002742 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471854002743 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471854002744 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854002745 binding surface 471854002746 TPR motif; other site 471854002747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854002748 binding surface 471854002749 Tetratricopeptide repeat; Region: TPR_16; pfam13432 471854002750 TPR motif; other site 471854002751 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 471854002752 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 471854002753 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 471854002754 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 471854002755 Cytochrome c; Region: Cytochrom_C; pfam00034 471854002756 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854002757 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854002758 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854002759 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854002760 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854002761 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 471854002762 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 471854002763 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471854002764 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 471854002765 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 471854002766 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 471854002767 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 471854002768 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854002769 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854002770 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854002771 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854002772 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854002773 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 471854002774 Predicted transcriptional regulator with an HTH domain [Transcription]; Region: COG4800 471854002775 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854002776 non-specific DNA binding site [nucleotide binding]; other site 471854002777 salt bridge; other site 471854002778 sequence-specific DNA binding site [nucleotide binding]; other site 471854002779 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 471854002780 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 471854002781 trimer interface [polypeptide binding]; other site 471854002782 active site 471854002783 substrate binding site [chemical binding]; other site 471854002784 CoA binding site [chemical binding]; other site 471854002785 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 471854002786 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 471854002787 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 471854002788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854002789 S-adenosylmethionine binding site [chemical binding]; other site 471854002790 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 471854002791 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471854002792 Sporulation related domain; Region: SPOR; pfam05036 471854002793 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854002794 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 471854002795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854002796 binding surface 471854002797 TPR motif; other site 471854002798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854002799 binding surface 471854002800 TPR motif; other site 471854002801 TPR repeat; Region: TPR_11; pfam13414 471854002802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854002803 binding surface 471854002804 TPR motif; other site 471854002805 TPR repeat; Region: TPR_11; pfam13414 471854002806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854002807 TPR motif; other site 471854002808 binding surface 471854002809 TPR repeat; Region: TPR_11; pfam13414 471854002810 TPR repeat; Region: TPR_11; pfam13414 471854002811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854002812 binding surface 471854002813 TPR motif; other site 471854002814 TPR repeat; Region: TPR_11; pfam13414 471854002815 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 471854002816 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 471854002817 dimer interface [polypeptide binding]; other site 471854002818 tetramer interface [polypeptide binding]; other site 471854002819 PYR/PP interface [polypeptide binding]; other site 471854002820 TPP binding site [chemical binding]; other site 471854002821 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 471854002822 TPP-binding site; other site 471854002823 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 471854002824 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471854002825 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854002826 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471854002827 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854002828 DNA binding residues [nucleotide binding] 471854002829 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 471854002830 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 471854002831 oligomer interface [polypeptide binding]; other site 471854002832 RNA binding site [nucleotide binding]; other site 471854002833 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 471854002834 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 471854002835 RNase E interface [polypeptide binding]; other site 471854002836 trimer interface [polypeptide binding]; other site 471854002837 active site 471854002838 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 471854002839 putative nucleic acid binding region [nucleotide binding]; other site 471854002840 G-X-X-G motif; other site 471854002841 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 471854002842 RNA binding site [nucleotide binding]; other site 471854002843 domain interface; other site 471854002844 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 471854002845 16S/18S rRNA binding site [nucleotide binding]; other site 471854002846 S13e-L30e interaction site [polypeptide binding]; other site 471854002847 25S rRNA binding site [nucleotide binding]; other site 471854002848 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 471854002849 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 471854002850 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 471854002851 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 471854002852 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471854002853 hydrophobic ligand binding site; other site 471854002854 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471854002855 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471854002856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854002857 Walker A/P-loop; other site 471854002858 ATP binding site [chemical binding]; other site 471854002859 Q-loop/lid; other site 471854002860 ABC transporter signature motif; other site 471854002861 Walker B; other site 471854002862 D-loop; other site 471854002863 H-loop/switch region; other site 471854002864 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 471854002865 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 471854002866 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 471854002867 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471854002868 endonuclease III; Region: ENDO3c; smart00478 471854002869 minor groove reading motif; other site 471854002870 helix-hairpin-helix signature motif; other site 471854002871 substrate binding pocket [chemical binding]; other site 471854002872 active site 471854002873 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 471854002874 DNA polymerase III, delta subunit; Region: holA; TIGR01128 471854002875 Protein of unknown function, DUF479; Region: DUF479; cl01203 471854002876 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 471854002877 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471854002878 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 471854002879 catalytic motif [active] 471854002880 Zn binding site [ion binding]; other site 471854002881 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 471854002882 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 471854002883 Competence protein; Region: Competence; pfam03772 471854002884 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 471854002885 active site 471854002886 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854002887 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 471854002888 PhoH-like protein; Region: PhoH; pfam02562 471854002889 replicative DNA helicase; Region: DnaB; TIGR00665 471854002890 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 471854002891 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 471854002892 Walker A motif; other site 471854002893 ATP binding site [chemical binding]; other site 471854002894 Walker B motif; other site 471854002895 DNA binding loops [nucleotide binding] 471854002896 Peptidase C10 family; Region: Peptidase_C10; pfam01640 471854002897 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 471854002898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854002899 S-adenosylmethionine binding site [chemical binding]; other site 471854002900 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 471854002901 Transcriptional regulator; Region: Rrf2; pfam02082 471854002902 Rrf2 family protein; Region: rrf2_super; TIGR00738 471854002903 Transcriptional regulator; Region: Rrf2; cl17282 471854002904 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 471854002905 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471854002906 NAD binding site [chemical binding]; other site 471854002907 substrate binding site [chemical binding]; other site 471854002908 putative active site [active] 471854002909 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471854002910 hydrophobic ligand binding site; other site 471854002911 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 471854002912 putative hydrophobic ligand binding site [chemical binding]; other site 471854002913 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471854002914 hydrophobic ligand binding site; other site 471854002915 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 471854002916 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 471854002917 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 471854002918 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 471854002919 RNA binding site [nucleotide binding]; other site 471854002920 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471854002921 16S rRNA methyltransferase B; Provisional; Region: PRK14902 471854002922 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 471854002923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854002924 S-adenosylmethionine binding site [chemical binding]; other site 471854002925 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471854002926 GAF domain; Region: GAF; pfam01590 471854002927 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854002928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854002929 dimer interface [polypeptide binding]; other site 471854002930 phosphorylation site [posttranslational modification] 471854002931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854002932 ATP binding site [chemical binding]; other site 471854002933 Mg2+ binding site [ion binding]; other site 471854002934 G-X-G motif; other site 471854002935 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 471854002936 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 471854002937 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 471854002938 Predicted transcriptional regulator [Transcription]; Region: COG2378 471854002939 HTH domain; Region: HTH_11; pfam08279 471854002940 WYL domain; Region: WYL; pfam13280 471854002941 DinB family; Region: DinB; cl17821 471854002942 DinB superfamily; Region: DinB_2; pfam12867 471854002943 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 471854002944 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471854002945 homodimer interface [polypeptide binding]; other site 471854002946 substrate-cofactor binding pocket; other site 471854002947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854002948 catalytic residue [active] 471854002949 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 471854002950 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854002951 DNA polymerase I; Region: pola; TIGR00593 471854002952 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471854002953 active site 471854002954 metal binding site 1 [ion binding]; metal-binding site 471854002955 putative 5' ssDNA interaction site; other site 471854002956 metal binding site 3; metal-binding site 471854002957 metal binding site 2 [ion binding]; metal-binding site 471854002958 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471854002959 putative DNA binding site [nucleotide binding]; other site 471854002960 putative metal binding site [ion binding]; other site 471854002961 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 471854002962 active site 471854002963 catalytic site [active] 471854002964 substrate binding site [chemical binding]; other site 471854002965 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 471854002966 active site 471854002967 DNA binding site [nucleotide binding] 471854002968 catalytic site [active] 471854002969 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 471854002970 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854002971 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854002972 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854002973 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854002974 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854002975 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854002976 PA14 domain; Region: PA14; cl08459 471854002977 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 471854002978 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 471854002979 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854002980 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854002981 DNA binding residues [nucleotide binding] 471854002982 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854002983 FecR protein; Region: FecR; pfam04773 471854002984 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854002985 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854002986 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854002987 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854002988 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854002989 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 471854002990 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854002991 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 471854002992 galactonate dehydratase; Provisional; Region: PRK14017 471854002993 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 471854002994 active site pocket [active] 471854002995 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 471854002996 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 471854002997 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471854002998 Ligand Binding Site [chemical binding]; other site 471854002999 TLC ATP/ADP transporter; Region: TLC; cl03940 471854003000 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471854003001 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471854003002 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471854003003 ligand binding site [chemical binding]; other site 471854003004 flexible hinge region; other site 471854003005 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471854003006 Zn2+ binding site [ion binding]; other site 471854003007 Mg2+ binding site [ion binding]; other site 471854003008 Response regulator receiver domain; Region: Response_reg; pfam00072 471854003009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854003010 active site 471854003011 phosphorylation site [posttranslational modification] 471854003012 intermolecular recognition site; other site 471854003013 dimerization interface [polypeptide binding]; other site 471854003014 cyclase homology domain; Region: CHD; cd07302 471854003015 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 471854003016 nucleotidyl binding site; other site 471854003017 metal binding site [ion binding]; metal-binding site 471854003018 dimer interface [polypeptide binding]; other site 471854003019 Response regulator receiver domain; Region: Response_reg; pfam00072 471854003020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854003021 active site 471854003022 phosphorylation site [posttranslational modification] 471854003023 intermolecular recognition site; other site 471854003024 dimerization interface [polypeptide binding]; other site 471854003025 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 471854003026 dimer interface [polypeptide binding]; other site 471854003027 phosphorylation site [posttranslational modification] 471854003028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854003029 ATP binding site [chemical binding]; other site 471854003030 Mg2+ binding site [ion binding]; other site 471854003031 G-X-G motif; other site 471854003032 short chain dehydrogenase; Provisional; Region: PRK06180 471854003033 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 471854003034 NADP binding site [chemical binding]; other site 471854003035 active site 471854003036 steroid binding site; other site 471854003037 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854003038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854003039 Methyltransferase domain; Region: Methyltransf_11; pfam08241 471854003040 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471854003041 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471854003042 ligand binding site [chemical binding]; other site 471854003043 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 471854003044 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854003045 FtsX-like permease family; Region: FtsX; pfam02687 471854003046 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854003047 FtsX-like permease family; Region: FtsX; pfam02687 471854003048 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 471854003049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854003050 non-specific DNA binding site [nucleotide binding]; other site 471854003051 salt bridge; other site 471854003052 sequence-specific DNA binding site [nucleotide binding]; other site 471854003053 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 471854003054 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 471854003055 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854003056 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854003057 DNA binding residues [nucleotide binding] 471854003058 Putative zinc-finger; Region: zf-HC2; pfam13490 471854003059 HEAT repeats; Region: HEAT_2; pfam13646 471854003060 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 471854003061 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 471854003062 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471854003063 MarR family; Region: MarR_2; pfam12802 471854003064 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 471854003065 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 471854003066 Cl- selectivity filter; other site 471854003067 Cl- binding residues [ion binding]; other site 471854003068 pore gating glutamate residue; other site 471854003069 dimer interface [polypeptide binding]; other site 471854003070 FOG: CBS domain [General function prediction only]; Region: COG0517 471854003071 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 471854003072 Response regulator receiver domain; Region: Response_reg; pfam00072 471854003073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854003074 active site 471854003075 phosphorylation site [posttranslational modification] 471854003076 intermolecular recognition site; other site 471854003077 dimerization interface [polypeptide binding]; other site 471854003078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854003079 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854003080 putative active site [active] 471854003081 heme pocket [chemical binding]; other site 471854003082 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 471854003083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854003084 ATP binding site [chemical binding]; other site 471854003085 Mg2+ binding site [ion binding]; other site 471854003086 G-X-G motif; other site 471854003087 Response regulator receiver domain; Region: Response_reg; pfam00072 471854003088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854003089 active site 471854003090 phosphorylation site [posttranslational modification] 471854003091 intermolecular recognition site; other site 471854003092 dimerization interface [polypeptide binding]; other site 471854003093 CheB methylesterase; Region: CheB_methylest; pfam01339 471854003094 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 471854003095 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 471854003096 CHASE3 domain; Region: CHASE3; pfam05227 471854003097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854003098 dimer interface [polypeptide binding]; other site 471854003099 phosphorylation site [posttranslational modification] 471854003100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854003101 ATP binding site [chemical binding]; other site 471854003102 Mg2+ binding site [ion binding]; other site 471854003103 G-X-G motif; other site 471854003104 Response regulator receiver domain; Region: Response_reg; pfam00072 471854003105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854003106 active site 471854003107 phosphorylation site [posttranslational modification] 471854003108 intermolecular recognition site; other site 471854003109 dimerization interface [polypeptide binding]; other site 471854003110 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471854003111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854003112 active site 471854003113 phosphorylation site [posttranslational modification] 471854003114 intermolecular recognition site; other site 471854003115 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471854003116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854003117 active site 471854003118 phosphorylation site [posttranslational modification] 471854003119 intermolecular recognition site; other site 471854003120 dimerization interface [polypeptide binding]; other site 471854003121 putative recombination protein RecB; Provisional; Region: PRK13909 471854003122 Family description; Region: UvrD_C_2; pfam13538 471854003123 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 471854003124 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471854003125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854003126 homodimer interface [polypeptide binding]; other site 471854003127 catalytic residue [active] 471854003128 RES domain; Region: RES; pfam08808 471854003129 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 471854003130 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 471854003131 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 471854003132 histidinol dehydrogenase; Region: hisD; TIGR00069 471854003133 NAD binding site [chemical binding]; other site 471854003134 dimerization interface [polypeptide binding]; other site 471854003135 product binding site; other site 471854003136 substrate binding site [chemical binding]; other site 471854003137 zinc binding site [ion binding]; other site 471854003138 catalytic residues [active] 471854003139 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 471854003140 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 471854003141 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 471854003142 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 471854003143 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 471854003144 dimer interface [polypeptide binding]; other site 471854003145 motif 1; other site 471854003146 active site 471854003147 motif 2; other site 471854003148 motif 3; other site 471854003149 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 471854003150 anticodon binding site; other site 471854003151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854003152 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471854003153 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471854003154 active site 471854003155 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 471854003156 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471854003157 inhibitor-cofactor binding pocket; inhibition site 471854003158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854003159 catalytic residue [active] 471854003160 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 471854003161 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 471854003162 ligand binding site [chemical binding]; other site 471854003163 membrane protein insertase; Provisional; Region: PRK01318 471854003164 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 471854003165 CTP synthetase; Validated; Region: pyrG; PRK05380 471854003166 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 471854003167 Catalytic site [active] 471854003168 active site 471854003169 UTP binding site [chemical binding]; other site 471854003170 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 471854003171 active site 471854003172 putative oxyanion hole; other site 471854003173 catalytic triad [active] 471854003174 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471854003175 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 471854003176 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 471854003177 dimer interface [polypeptide binding]; other site 471854003178 active site 471854003179 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471854003180 catalytic residues [active] 471854003181 substrate binding site [chemical binding]; other site 471854003182 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 471854003183 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471854003184 active site 471854003185 catalytic site [active] 471854003186 substrate binding site [chemical binding]; other site 471854003187 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 471854003188 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854003189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854003190 Outer membrane efflux protein; Region: OEP; pfam02321 471854003191 Outer membrane efflux protein; Region: OEP; pfam02321 471854003192 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 471854003193 Protein export membrane protein; Region: SecD_SecF; cl14618 471854003194 Protein export membrane protein; Region: SecD_SecF; cl14618 471854003195 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854003196 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854003197 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854003198 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471854003199 Beta-lactamase; Region: Beta-lactamase; pfam00144 471854003200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854003201 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471854003202 putative substrate translocation pore; other site 471854003203 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471854003204 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471854003205 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 471854003206 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471854003207 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471854003208 AP (apurinic/apyrimidinic) site pocket; other site 471854003209 DNA interaction; other site 471854003210 Metal-binding active site; metal-binding site 471854003211 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 471854003212 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 471854003213 PIN domain; Region: PIN_3; cl17397 471854003214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854003215 S-adenosylmethionine binding site [chemical binding]; other site 471854003216 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 471854003217 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 471854003218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854003219 putative substrate translocation pore; other site 471854003220 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471854003221 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471854003222 P-loop; other site 471854003223 Magnesium ion binding site [ion binding]; other site 471854003224 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471854003225 Magnesium ion binding site [ion binding]; other site 471854003226 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471854003227 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471854003228 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471854003229 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 471854003230 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854003231 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 471854003232 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471854003233 catalytic residue [active] 471854003234 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 471854003235 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 471854003236 EamA-like transporter family; Region: EamA; pfam00892 471854003237 EamA-like transporter family; Region: EamA; pfam00892 471854003238 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471854003239 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471854003240 DNA-binding site [nucleotide binding]; DNA binding site 471854003241 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471854003242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854003243 homodimer interface [polypeptide binding]; other site 471854003244 catalytic residue [active] 471854003245 PemK-like protein; Region: PemK; pfam02452 471854003246 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 471854003247 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 471854003248 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471854003249 Soluble P-type ATPase [General function prediction only]; Region: COG4087 471854003250 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471854003251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854003252 non-specific DNA binding site [nucleotide binding]; other site 471854003253 salt bridge; other site 471854003254 sequence-specific DNA binding site [nucleotide binding]; other site 471854003255 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471854003256 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471854003257 DNA-binding site [nucleotide binding]; DNA binding site 471854003258 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471854003259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854003260 homodimer interface [polypeptide binding]; other site 471854003261 catalytic residue [active] 471854003262 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 471854003263 YceI-like domain; Region: YceI; pfam04264 471854003264 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854003265 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854003266 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 471854003267 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 471854003268 active site residue [active] 471854003269 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 471854003270 active site residue [active] 471854003271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854003272 Coenzyme A binding pocket [chemical binding]; other site 471854003273 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471854003274 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471854003275 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 471854003276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471854003277 FeS/SAM binding site; other site 471854003278 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 471854003279 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cd02795 471854003280 metal binding site [ion binding]; metal-binding site 471854003281 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cd02795 471854003282 metal binding site [ion binding]; metal-binding site 471854003283 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cd02795 471854003284 metal binding site [ion binding]; metal-binding site 471854003285 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854003286 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 471854003287 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 471854003288 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471854003289 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854003290 lipoprotein signal peptidase; Provisional; Region: PRK14787 471854003291 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 471854003292 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 471854003293 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584 471854003294 substrate binding site [chemical binding]; other site 471854003295 ligand binding site [chemical binding]; other site 471854003296 Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578 471854003297 substrate binding site [chemical binding]; other site 471854003298 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 471854003299 Aconitate hydratase 2 N-terminus; Region: Aconitase_2_N; pfam06434 471854003300 substrate binding site [chemical binding]; other site 471854003301 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 471854003302 substrate binding site [chemical binding]; other site 471854003303 ligand binding site [chemical binding]; other site 471854003304 DNA topoisomerase I; Provisional; Region: PRK08780 471854003305 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 471854003306 active site 471854003307 interdomain interaction site; other site 471854003308 putative metal-binding site [ion binding]; other site 471854003309 nucleotide binding site [chemical binding]; other site 471854003310 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 471854003311 domain I; other site 471854003312 DNA binding groove [nucleotide binding] 471854003313 phosphate binding site [ion binding]; other site 471854003314 domain II; other site 471854003315 domain III; other site 471854003316 nucleotide binding site [chemical binding]; other site 471854003317 catalytic site [active] 471854003318 domain IV; other site 471854003319 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 471854003320 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 471854003321 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 471854003322 NAD-dependent deacetylase; Provisional; Region: PRK00481 471854003323 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 471854003324 NAD+ binding site [chemical binding]; other site 471854003325 substrate binding site [chemical binding]; other site 471854003326 Zn binding site [ion binding]; other site 471854003327 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 471854003328 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 471854003329 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 471854003330 homodimer interface [polypeptide binding]; other site 471854003331 NADP binding site [chemical binding]; other site 471854003332 substrate binding site [chemical binding]; other site 471854003333 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471854003334 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854003335 non-specific DNA binding site [nucleotide binding]; other site 471854003336 salt bridge; other site 471854003337 sequence-specific DNA binding site [nucleotide binding]; other site 471854003338 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471854003339 acyl-activating enzyme (AAE) consensus motif; other site 471854003340 AMP binding site [chemical binding]; other site 471854003341 active site 471854003342 CoA binding site [chemical binding]; other site 471854003343 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471854003344 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 471854003345 substrate binding site [chemical binding]; other site 471854003346 oxyanion hole (OAH) forming residues; other site 471854003347 trimer interface [polypeptide binding]; other site 471854003348 EVE domain; Region: EVE; pfam01878 471854003349 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 471854003350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854003351 S-adenosylmethionine binding site [chemical binding]; other site 471854003352 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854003353 binding surface 471854003354 TPR motif; other site 471854003355 TPR repeat; Region: TPR_11; pfam13414 471854003356 TPR repeat; Region: TPR_11; pfam13414 471854003357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854003358 binding surface 471854003359 TPR motif; other site 471854003360 TPR repeat; Region: TPR_11; pfam13414 471854003361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854003362 binding surface 471854003363 TPR motif; other site 471854003364 TPR repeat; Region: TPR_11; pfam13414 471854003365 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 471854003366 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 471854003367 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 471854003368 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 471854003369 active site 471854003370 dimer interface [polypeptide binding]; other site 471854003371 motif 1; other site 471854003372 motif 2; other site 471854003373 motif 3; other site 471854003374 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 471854003375 anticodon binding site; other site 471854003376 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 471854003377 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 471854003378 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 471854003379 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 471854003380 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 471854003381 23S rRNA binding site [nucleotide binding]; other site 471854003382 L21 binding site [polypeptide binding]; other site 471854003383 L13 binding site [polypeptide binding]; other site 471854003384 Phosphoesterase family; Region: Phosphoesterase; pfam04185 471854003385 Phosphoesterase family; Region: Phosphoesterase; pfam04185 471854003386 Domain of unknown function (DUF756); Region: DUF756; pfam05506 471854003387 Domain of unknown function (DUF756); Region: DUF756; pfam05506 471854003388 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 471854003389 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 471854003390 nucleotide binding site [chemical binding]; other site 471854003391 NEF interaction site [polypeptide binding]; other site 471854003392 SBD interface [polypeptide binding]; other site 471854003393 glucose-1-dehydrogenase; Provisional; Region: PRK08936 471854003394 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 471854003395 NAD binding site [chemical binding]; other site 471854003396 homodimer interface [polypeptide binding]; other site 471854003397 active site 471854003398 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 471854003399 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854003400 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 471854003401 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 471854003402 active site 471854003403 dimer interface [polypeptide binding]; other site 471854003404 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 471854003405 dimer interface [polypeptide binding]; other site 471854003406 active site 471854003407 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471854003408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 471854003409 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 471854003410 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471854003411 RNA binding surface [nucleotide binding]; other site 471854003412 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 471854003413 probable active site [active] 471854003414 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 471854003415 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854003416 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854003417 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854003418 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 471854003419 Ligand binding site [chemical binding]; other site 471854003420 Electron transfer flavoprotein domain; Region: ETF; pfam01012 471854003421 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 471854003422 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 471854003423 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 471854003424 Bifunctional nuclease; Region: DNase-RNase; pfam02577 471854003425 UvrB/uvrC motif; Region: UVR; pfam02151 471854003426 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 471854003427 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 471854003428 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 471854003429 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 471854003430 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 471854003431 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 471854003432 RNA binding site [nucleotide binding]; other site 471854003433 active site 471854003434 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 471854003435 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 471854003436 active site 471854003437 Riboflavin kinase; Region: Flavokinase; smart00904 471854003438 mercuric reductase; Validated; Region: PRK06370 471854003439 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 471854003440 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471854003441 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471854003442 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471854003443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854003444 Walker A/P-loop; other site 471854003445 ATP binding site [chemical binding]; other site 471854003446 Q-loop/lid; other site 471854003447 ABC transporter signature motif; other site 471854003448 Walker B; other site 471854003449 D-loop; other site 471854003450 H-loop/switch region; other site 471854003451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471854003452 dimer interface [polypeptide binding]; other site 471854003453 conserved gate region; other site 471854003454 putative PBP binding loops; other site 471854003455 ABC-ATPase subunit interface; other site 471854003456 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 471854003457 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 471854003458 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 471854003459 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 471854003460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471854003461 DinB family; Region: DinB; cl17821 471854003462 DinB superfamily; Region: DinB_2; pfam12867 471854003463 H+ Antiporter protein; Region: 2A0121; TIGR00900 471854003464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854003465 putative substrate translocation pore; other site 471854003466 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471854003467 active site 471854003468 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854003469 DinB superfamily; Region: DinB_2; pfam12867 471854003470 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 471854003471 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471854003472 DoxX-like family; Region: DoxX_2; pfam13564 471854003473 DinB superfamily; Region: DinB_2; pfam12867 471854003474 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471854003475 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471854003476 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471854003477 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 471854003478 metal binding site [ion binding]; metal-binding site 471854003479 substrate binding pocket [chemical binding]; other site 471854003480 Class I aldolases; Region: Aldolase_Class_I; cl17187 471854003481 catalytic residue [active] 471854003482 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471854003483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854003484 NAD(P) binding site [chemical binding]; other site 471854003485 active site 471854003486 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 471854003487 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 471854003488 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471854003489 DNA binding site [nucleotide binding] 471854003490 domain linker motif; other site 471854003491 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 471854003492 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 471854003493 ligand binding site [chemical binding]; other site 471854003494 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 471854003495 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854003496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854003497 active site 471854003498 phosphorylation site [posttranslational modification] 471854003499 intermolecular recognition site; other site 471854003500 dimerization interface [polypeptide binding]; other site 471854003501 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854003502 DNA binding residues [nucleotide binding] 471854003503 dimerization interface [polypeptide binding]; other site 471854003504 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854003505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854003506 active site 471854003507 phosphorylation site [posttranslational modification] 471854003508 intermolecular recognition site; other site 471854003509 dimerization interface [polypeptide binding]; other site 471854003510 LytTr DNA-binding domain; Region: LytTR; pfam04397 471854003511 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 471854003512 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 471854003513 Histidine kinase; Region: His_kinase; pfam06580 471854003514 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854003515 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854003516 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854003517 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 471854003518 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854003519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854003520 active site 471854003521 phosphorylation site [posttranslational modification] 471854003522 intermolecular recognition site; other site 471854003523 dimerization interface [polypeptide binding]; other site 471854003524 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854003525 DNA binding residues [nucleotide binding] 471854003526 dimerization interface [polypeptide binding]; other site 471854003527 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854003528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854003529 active site 471854003530 phosphorylation site [posttranslational modification] 471854003531 intermolecular recognition site; other site 471854003532 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854003533 DNA binding residues [nucleotide binding] 471854003534 dimerization interface [polypeptide binding]; other site 471854003535 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854003536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854003537 active site 471854003538 phosphorylation site [posttranslational modification] 471854003539 intermolecular recognition site; other site 471854003540 dimerization interface [polypeptide binding]; other site 471854003541 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854003542 DNA binding residues [nucleotide binding] 471854003543 dimerization interface [polypeptide binding]; other site 471854003544 Penicillinase repressor; Region: Pencillinase_R; pfam03965 471854003545 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 471854003546 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 471854003547 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 471854003548 active site 471854003549 FMN binding site [chemical binding]; other site 471854003550 substrate binding site [chemical binding]; other site 471854003551 putative catalytic residue [active] 471854003552 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471854003553 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471854003554 ligand binding site [chemical binding]; other site 471854003555 flexible hinge region; other site 471854003556 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 471854003557 classical (c) SDRs; Region: SDR_c; cd05233 471854003558 NAD(P) binding site [chemical binding]; other site 471854003559 active site 471854003560 Predicted transcriptional regulators [Transcription]; Region: COG1733 471854003561 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471854003562 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 471854003563 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 471854003564 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854003565 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854003566 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854003567 DNA binding residues [nucleotide binding] 471854003568 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 471854003569 Mechanosensitive ion channel; Region: MS_channel; pfam00924 471854003570 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 471854003571 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471854003572 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 471854003573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854003574 active site 471854003575 phosphorylation site [posttranslational modification] 471854003576 intermolecular recognition site; other site 471854003577 dimerization interface [polypeptide binding]; other site 471854003578 LytTr DNA-binding domain; Region: LytTR; smart00850 471854003579 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471854003580 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854003581 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471854003582 FAD binding domain; Region: FAD_binding_4; pfam01565 471854003583 Berberine and berberine like; Region: BBE; pfam08031 471854003584 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 471854003585 Transglycosylase; Region: Transgly; pfam00912 471854003586 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 471854003587 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854003588 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854003589 short chain dehydrogenase; Provisional; Region: PRK08263 471854003590 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 471854003591 NADP binding site [chemical binding]; other site 471854003592 active site 471854003593 steroid binding site; other site 471854003594 GAF domain; Region: GAF_2; pfam13185 471854003595 GAF domain; Region: GAF; pfam01590 471854003596 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 471854003597 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 471854003598 putative DNA binding helix; other site 471854003599 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 471854003600 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 471854003601 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 471854003602 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 471854003603 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 471854003604 Histidine kinase; Region: His_kinase; pfam06580 471854003605 Histidine kinase; Region: His_kinase; pfam06580 471854003606 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854003607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854003608 active site 471854003609 phosphorylation site [posttranslational modification] 471854003610 intermolecular recognition site; other site 471854003611 dimerization interface [polypeptide binding]; other site 471854003612 LytTr DNA-binding domain; Region: LytTR; pfam04397 471854003613 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471854003614 active site 471854003615 metal binding site [ion binding]; metal-binding site 471854003616 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471854003617 RNA polymerase sigma factor; Provisional; Region: PRK11924 471854003618 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854003619 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854003620 DNA binding residues [nucleotide binding] 471854003621 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 471854003622 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471854003623 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471854003624 active site 471854003625 metal binding site [ion binding]; metal-binding site 471854003626 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 471854003627 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471854003628 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471854003629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854003630 Walker A/P-loop; other site 471854003631 ATP binding site [chemical binding]; other site 471854003632 Q-loop/lid; other site 471854003633 ABC transporter signature motif; other site 471854003634 Walker B; other site 471854003635 D-loop; other site 471854003636 H-loop/switch region; other site 471854003637 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 471854003638 dimer interface [polypeptide binding]; other site 471854003639 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 471854003640 dimer interface [polypeptide binding]; other site 471854003641 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 471854003642 conserved cys residue [active] 471854003643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854003644 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854003645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854003646 Uncharacterized proteins similar to Bacteroides ovatus 4320; Region: Bacova_04320_like; cd12190 471854003647 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 471854003648 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 471854003649 Sulfatase; Region: Sulfatase; cl17466 471854003650 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 471854003651 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 471854003652 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 471854003653 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 471854003654 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 471854003655 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 471854003656 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 471854003657 Phage Tail Collar Domain; Region: Collar; pfam07484 471854003658 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 471854003659 Phage Tail Collar Domain; Region: Collar; pfam07484 471854003660 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 471854003661 Phage Tail Collar Domain; Region: Collar; pfam07484 471854003662 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471854003663 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854003664 Coenzyme A binding pocket [chemical binding]; other site 471854003665 conserved repeat domain; Region: B_ant_repeat; TIGR01451 471854003666 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854003667 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854003668 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854003669 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854003670 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854003671 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854003672 SusD family; Region: SusD; pfam07980 471854003673 Protein of unknown function (DUF3823); Region: DUF3823; pfam12866 471854003674 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 471854003675 putative ligand binding site [chemical binding]; other site 471854003676 putative catalytic site [active] 471854003677 Uncharacterized conserved protein [Function unknown]; Region: COG5476 471854003678 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 471854003679 MlrC C-terminus; Region: MlrC_C; pfam07171 471854003680 RibD C-terminal domain; Region: RibD_C; cl17279 471854003681 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471854003682 Predicted transcriptional regulators [Transcription]; Region: COG1733 471854003683 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471854003684 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 471854003685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854003686 NAD(P) binding site [chemical binding]; other site 471854003687 active site 471854003688 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 471854003689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854003690 S-adenosylmethionine binding site [chemical binding]; other site 471854003691 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 471854003692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854003693 Walker A motif; other site 471854003694 ATP binding site [chemical binding]; other site 471854003695 Walker B motif; other site 471854003696 arginine finger; other site 471854003697 RibD C-terminal domain; Region: RibD_C; cl17279 471854003698 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 471854003699 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 471854003700 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 471854003701 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 471854003702 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 471854003703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854003704 non-specific DNA binding site [nucleotide binding]; other site 471854003705 salt bridge; other site 471854003706 sequence-specific DNA binding site [nucleotide binding]; other site 471854003707 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 471854003708 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 471854003709 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471854003710 PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121 471854003711 apical/protease domain interface [polypeptide binding]; other site 471854003712 substrate binding [chemical binding]; other site 471854003713 dimer interface [polypeptide binding]; other site 471854003714 M28 Zn-peptidase prostate-specific membrane antigen; Region: M28_PSMA_like; cd08022 471854003715 dimer interface [polypeptide binding]; other site 471854003716 active site 471854003717 metal binding site [ion binding]; metal-binding site 471854003718 Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253 471854003719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854003720 non-specific DNA binding site [nucleotide binding]; other site 471854003721 salt bridge; other site 471854003722 sequence-specific DNA binding site [nucleotide binding]; other site 471854003723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 471854003724 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 471854003725 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471854003726 Trehalose utilisation; Region: ThuA; pfam06283 471854003727 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 471854003728 HEAT repeats; Region: HEAT_2; pfam13646 471854003729 HEAT repeats; Region: HEAT_2; pfam13646 471854003730 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 471854003731 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 471854003732 active site 471854003733 catalytic triad [active] 471854003734 oxyanion hole [active] 471854003735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854003736 D-galactonate transporter; Region: 2A0114; TIGR00893 471854003737 putative substrate translocation pore; other site 471854003738 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471854003739 active site 471854003740 oxyanion hole [active] 471854003741 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471854003742 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 471854003743 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 471854003744 metal binding site [ion binding]; metal-binding site 471854003745 substrate binding pocket [chemical binding]; other site 471854003746 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 471854003747 Trp docking motif [polypeptide binding]; other site 471854003748 putative active site [active] 471854003749 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471854003750 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 471854003751 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 471854003752 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854003753 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854003754 SusD family; Region: SusD; pfam07980 471854003755 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854003756 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854003757 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854003758 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854003759 FecR protein; Region: FecR; pfam04773 471854003760 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854003761 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854003762 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854003763 DNA binding residues [nucleotide binding] 471854003764 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 471854003765 putative active site [active] 471854003766 catalytic site [active] 471854003767 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 471854003768 Alkaline phosphatase homologues; Region: alkPPc; smart00098 471854003769 active site 471854003770 dimer interface [polypeptide binding]; other site 471854003771 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854003772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854003773 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 471854003774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854003775 NAD(P) binding site [chemical binding]; other site 471854003776 active site 471854003777 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 471854003778 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 471854003779 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854003780 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 471854003781 oxyanion hole [active] 471854003782 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471854003783 catalytic triad [active] 471854003784 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854003785 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854003786 SusD family; Region: SusD; pfam07980 471854003787 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854003788 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854003789 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854003790 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 471854003791 ApbE family; Region: ApbE; pfam02424 471854003792 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854003793 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854003794 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471854003795 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 471854003796 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854003797 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854003798 DNA binding residues [nucleotide binding] 471854003799 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 471854003800 active site 471854003801 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471854003802 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471854003803 active site 471854003804 metal binding site [ion binding]; metal-binding site 471854003805 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854003806 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854003807 Cupin domain; Region: Cupin_2; pfam07883 471854003808 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854003809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854003810 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 471854003811 Carboxylesterase family; Region: COesterase; pfam00135 471854003812 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 471854003813 substrate binding pocket [chemical binding]; other site 471854003814 catalytic triad [active] 471854003815 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471854003816 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 471854003817 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 471854003818 metal binding site [ion binding]; metal-binding site 471854003819 substrate binding pocket [chemical binding]; other site 471854003820 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 471854003821 mannonate dehydratase; Region: uxuA; TIGR00695 471854003822 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 471854003823 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 471854003824 fructuronate transporter; Provisional; Region: PRK10034; cl15264 471854003825 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 471854003826 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 471854003827 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854003828 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854003829 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854003830 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854003831 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854003832 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854003833 FecR protein; Region: FecR; pfam04773 471854003834 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854003835 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854003836 DNA binding residues [nucleotide binding] 471854003837 Predicted transcriptional regulators [Transcription]; Region: COG1733 471854003838 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471854003839 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 471854003840 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 471854003841 FMN binding site [chemical binding]; other site 471854003842 substrate binding site [chemical binding]; other site 471854003843 putative catalytic residue [active] 471854003844 GTPase RsgA; Reviewed; Region: PRK01889 471854003845 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471854003846 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 471854003847 GTPase/Zn-binding domain interface [polypeptide binding]; other site 471854003848 GTP/Mg2+ binding site [chemical binding]; other site 471854003849 G4 box; other site 471854003850 G5 box; other site 471854003851 G1 box; other site 471854003852 Switch I region; other site 471854003853 G2 box; other site 471854003854 G3 box; other site 471854003855 Switch II region; other site 471854003856 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854003857 SusD family; Region: SusD; pfam07980 471854003858 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854003859 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854003860 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854003861 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854003862 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854003863 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854003864 FecR protein; Region: FecR; pfam04773 471854003865 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854003866 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854003867 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854003868 DNA binding residues [nucleotide binding] 471854003869 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 471854003870 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854003871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854003872 Domain of unknown function (DUF4374); Region: DUF4374; pfam14298 471854003873 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854003874 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 471854003875 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854003876 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854003877 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 471854003878 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 471854003879 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471854003880 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 471854003881 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 471854003882 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 471854003883 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471854003884 catalytic loop [active] 471854003885 iron binding site [ion binding]; other site 471854003886 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 471854003887 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 471854003888 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 471854003889 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854003890 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471854003891 Trehalose utilisation; Region: ThuA; pfam06283 471854003892 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 471854003893 HEAT repeats; Region: HEAT_2; pfam13646 471854003894 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 471854003895 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 471854003896 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854003897 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854003898 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854003899 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854003900 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854003901 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854003902 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 471854003903 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 471854003904 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 471854003905 active site 471854003906 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 471854003907 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471854003908 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854003909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854003910 active site 471854003911 phosphorylation site [posttranslational modification] 471854003912 intermolecular recognition site; other site 471854003913 dimerization interface [polypeptide binding]; other site 471854003914 LytTr DNA-binding domain; Region: LytTR; smart00850 471854003915 Histidine kinase; Region: His_kinase; pfam06580 471854003916 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 471854003917 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854003918 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 471854003919 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 471854003920 putative hydrophobic ligand binding site [chemical binding]; other site 471854003921 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 471854003922 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 471854003923 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 471854003924 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854003925 FtsX-like permease family; Region: FtsX; pfam02687 471854003926 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854003927 FtsX-like permease family; Region: FtsX; pfam02687 471854003928 Predicted transcriptional regulators [Transcription]; Region: COG1695 471854003929 Transcriptional regulator PadR-like family; Region: PadR; cl17335 471854003930 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854003931 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854003932 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854003933 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854003934 Domain of unknown function (DUF4374); Region: DUF4374; pfam14298 471854003935 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854003936 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854003937 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854003938 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 471854003939 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854003940 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854003941 Uncharacterized conserved protein [Function unknown]; Region: COG2353 471854003942 Family description; Region: VCBS; pfam13517 471854003943 Family description; Region: VCBS; pfam13517 471854003944 Family description; Region: VCBS; pfam13517 471854003945 Family description; Region: VCBS; pfam13517 471854003946 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854003947 SusD family; Region: SusD; pfam07980 471854003948 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854003949 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854003950 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854003951 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854003952 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854003953 FecR protein; Region: FecR; pfam04773 471854003954 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854003955 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854003956 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854003957 DNA binding residues [nucleotide binding] 471854003958 GAF domain; Region: GAF_3; pfam13492 471854003959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854003960 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854003961 dimer interface [polypeptide binding]; other site 471854003962 phosphorylation site [posttranslational modification] 471854003963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854003964 ATP binding site [chemical binding]; other site 471854003965 Mg2+ binding site [ion binding]; other site 471854003966 G-X-G motif; other site 471854003967 Response regulator receiver domain; Region: Response_reg; pfam00072 471854003968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854003969 active site 471854003970 phosphorylation site [posttranslational modification] 471854003971 intermolecular recognition site; other site 471854003972 dimerization interface [polypeptide binding]; other site 471854003973 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854003974 PAS fold; Region: PAS_3; pfam08447 471854003975 putative active site [active] 471854003976 heme pocket [chemical binding]; other site 471854003977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854003978 dimer interface [polypeptide binding]; other site 471854003979 phosphorylation site [posttranslational modification] 471854003980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854003981 ATP binding site [chemical binding]; other site 471854003982 Mg2+ binding site [ion binding]; other site 471854003983 G-X-G motif; other site 471854003984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854003985 Response regulator receiver domain; Region: Response_reg; pfam00072 471854003986 active site 471854003987 phosphorylation site [posttranslational modification] 471854003988 intermolecular recognition site; other site 471854003989 dimerization interface [polypeptide binding]; other site 471854003990 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854003991 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854003992 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854003993 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471854003994 dimerization interface [polypeptide binding]; other site 471854003995 putative DNA binding site [nucleotide binding]; other site 471854003996 putative Zn2+ binding site [ion binding]; other site 471854003997 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 471854003998 putative hydrophobic ligand binding site [chemical binding]; other site 471854003999 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 471854004000 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471854004001 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471854004002 LysR substrate binding domain; Region: LysR_substrate; pfam03466 471854004003 dimerization interface [polypeptide binding]; other site 471854004004 Haem-binding domain; Region: Haem_bd; pfam14376 471854004005 Histidine kinase; Region: His_kinase; pfam06580 471854004006 Response regulator receiver domain; Region: Response_reg; pfam00072 471854004007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854004008 active site 471854004009 phosphorylation site [posttranslational modification] 471854004010 intermolecular recognition site; other site 471854004011 dimerization interface [polypeptide binding]; other site 471854004012 LytTr DNA-binding domain; Region: LytTR; pfam04397 471854004013 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 471854004014 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471854004015 DinB superfamily; Region: DinB_2; pfam12867 471854004016 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 471854004017 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 471854004018 nudix motif; other site 471854004019 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471854004020 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 471854004021 Cytochrome c; Region: Cytochrom_C; cl11414 471854004022 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 471854004023 metal binding site [ion binding]; metal-binding site 471854004024 ligand binding site [chemical binding]; other site 471854004025 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 471854004026 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 471854004027 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854004028 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854004029 SusD family; Region: SusD; pfam07980 471854004030 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004031 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004032 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004033 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854004034 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 471854004035 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 471854004036 Trp docking motif [polypeptide binding]; other site 471854004037 active site 471854004038 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 471854004039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854004040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854004041 dimer interface [polypeptide binding]; other site 471854004042 phosphorylation site [posttranslational modification] 471854004043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854004044 ATP binding site [chemical binding]; other site 471854004045 Mg2+ binding site [ion binding]; other site 471854004046 G-X-G motif; other site 471854004047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854004048 Response regulator receiver domain; Region: Response_reg; pfam00072 471854004049 active site 471854004050 phosphorylation site [posttranslational modification] 471854004051 intermolecular recognition site; other site 471854004052 dimerization interface [polypeptide binding]; other site 471854004053 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854004054 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854004055 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 471854004056 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 471854004057 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 471854004058 catalytic site [active] 471854004059 active site 471854004060 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 471854004061 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471854004062 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 471854004063 sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377 471854004064 hydroxyglutarate oxidase; Provisional; Region: PRK11728 471854004065 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854004066 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854004067 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854004068 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854004069 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471854004070 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854004071 FecR protein; Region: FecR; pfam04773 471854004072 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854004073 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004074 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004075 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004076 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854004077 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854004078 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854004079 SusD family; Region: SusD; pfam07980 471854004080 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 471854004081 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 471854004082 active site 471854004083 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854004084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854004085 active site 471854004086 phosphorylation site [posttranslational modification] 471854004087 intermolecular recognition site; other site 471854004088 dimerization interface [polypeptide binding]; other site 471854004089 LytTr DNA-binding domain; Region: LytTR; smart00850 471854004090 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 471854004091 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 471854004092 Histidine kinase; Region: His_kinase; pfam06580 471854004093 DKNYY family; Region: DKNYY; pfam13644 471854004094 DKNYY family; Region: DKNYY; pfam13644 471854004095 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 471854004096 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471854004097 NAD binding site [chemical binding]; other site 471854004098 catalytic Zn binding site [ion binding]; other site 471854004099 structural Zn binding site [ion binding]; other site 471854004100 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 471854004101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854004102 putative substrate translocation pore; other site 471854004103 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 471854004104 active site 471854004105 oxidoreductase; Provisional; Region: PRK06196 471854004106 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 471854004107 putative NAD(P) binding site [chemical binding]; other site 471854004108 active site 471854004109 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471854004110 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471854004111 Sulfatase; Region: Sulfatase; pfam00884 471854004112 Response regulator receiver domain; Region: Response_reg; pfam00072 471854004113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854004114 active site 471854004115 phosphorylation site [posttranslational modification] 471854004116 intermolecular recognition site; other site 471854004117 dimerization interface [polypeptide binding]; other site 471854004118 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004119 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854004120 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 471854004121 N-terminal plug; other site 471854004122 ligand-binding site [chemical binding]; other site 471854004123 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471854004124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854004125 non-specific DNA binding site [nucleotide binding]; other site 471854004126 salt bridge; other site 471854004127 sequence-specific DNA binding site [nucleotide binding]; other site 471854004128 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 471854004129 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 471854004130 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 471854004131 active site 471854004132 catalytic triad [active] 471854004133 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471854004134 putative catalytic site [active] 471854004135 putative metal binding site [ion binding]; other site 471854004136 putative phosphate binding site [ion binding]; other site 471854004137 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 471854004138 putative substrate binding site [chemical binding]; other site 471854004139 active site 471854004140 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854004141 short chain dehydrogenase; Provisional; Region: PRK12939 471854004142 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 471854004143 NADP binding site [chemical binding]; other site 471854004144 homodimer interface [polypeptide binding]; other site 471854004145 active site 471854004146 substrate binding site [chemical binding]; other site 471854004147 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 471854004148 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 471854004149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854004150 Response regulator receiver domain; Region: Response_reg; pfam00072 471854004151 active site 471854004152 phosphorylation site [posttranslational modification] 471854004153 intermolecular recognition site; other site 471854004154 dimerization interface [polypeptide binding]; other site 471854004155 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854004156 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 471854004157 putative active site [active] 471854004158 heme pocket [chemical binding]; other site 471854004159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854004160 putative active site [active] 471854004161 heme pocket [chemical binding]; other site 471854004162 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471854004163 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854004164 putative active site [active] 471854004165 heme pocket [chemical binding]; other site 471854004166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854004167 dimer interface [polypeptide binding]; other site 471854004168 phosphorylation site [posttranslational modification] 471854004169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854004170 ATP binding site [chemical binding]; other site 471854004171 Mg2+ binding site [ion binding]; other site 471854004172 G-X-G motif; other site 471854004173 putative chaperone; Provisional; Region: PRK11678 471854004174 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 471854004175 nucleotide binding site [chemical binding]; other site 471854004176 putative NEF/HSP70 interaction site [polypeptide binding]; other site 471854004177 SBD interface [polypeptide binding]; other site 471854004178 hypothetical protein; Provisional; Region: PRK02399 471854004179 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 471854004180 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 471854004181 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 471854004182 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 471854004183 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471854004184 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 471854004185 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 471854004186 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 471854004187 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471854004188 catalytic loop [active] 471854004189 iron binding site [ion binding]; other site 471854004190 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 471854004191 Response regulator receiver domain; Region: Response_reg; pfam00072 471854004192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854004193 active site 471854004194 phosphorylation site [posttranslational modification] 471854004195 intermolecular recognition site; other site 471854004196 dimerization interface [polypeptide binding]; other site 471854004197 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854004198 FtsX-like permease family; Region: FtsX; pfam02687 471854004199 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854004200 FtsX-like permease family; Region: FtsX; pfam02687 471854004201 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 471854004202 Trehalose utilisation; Region: ThuA; pfam06283 471854004203 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 471854004204 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854004205 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 471854004206 Substrate binding site; other site 471854004207 metal-binding site 471854004208 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854004209 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 471854004210 Substrate binding site; other site 471854004211 metal-binding site 471854004212 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854004213 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 471854004214 metal-binding site 471854004215 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854004216 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 471854004217 metal-binding site 471854004218 WxcM-like, C-terminal; Region: FdtA; pfam05523 471854004219 putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325 471854004220 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 471854004221 A new structural DNA glycosylase; Region: AlkD_like; cd06561 471854004222 active site 471854004223 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 471854004224 homotrimer interaction site [polypeptide binding]; other site 471854004225 putative active site [active] 471854004226 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004227 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004228 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004229 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854004230 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854004231 SusD family; Region: SusD; pfam07980 471854004232 Transcriptional regulator PadR-like family; Region: PadR; cl17335 471854004233 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 471854004234 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 471854004235 PDZ domain; Region: PDZ_2; pfam13180 471854004236 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 471854004237 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 471854004238 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 471854004239 catalytic residues [active] 471854004240 Predicted transcriptional regulators [Transcription]; Region: COG1733 471854004241 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471854004242 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854004243 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854004244 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854004245 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004246 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004247 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004248 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854004249 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854004250 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854004251 FecR protein; Region: FecR; pfam04773 471854004252 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854004253 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854004254 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471854004255 DNA binding residues [nucleotide binding] 471854004256 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 471854004257 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 471854004258 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 471854004259 active site 471854004260 homotrimer interface [polypeptide binding]; other site 471854004261 catalytic site [active] 471854004262 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 471854004263 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 471854004264 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854004265 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854004266 SusD family; Region: SusD; pfam07980 471854004267 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004268 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004269 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004270 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 471854004271 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 471854004272 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854004273 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854004274 dimer interface [polypeptide binding]; other site 471854004275 phosphorylation site [posttranslational modification] 471854004276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854004277 ATP binding site [chemical binding]; other site 471854004278 Mg2+ binding site [ion binding]; other site 471854004279 G-X-G motif; other site 471854004280 Response regulator receiver domain; Region: Response_reg; pfam00072 471854004281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854004282 active site 471854004283 phosphorylation site [posttranslational modification] 471854004284 intermolecular recognition site; other site 471854004285 dimerization interface [polypeptide binding]; other site 471854004286 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854004287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854004288 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 471854004289 FAD binding site [chemical binding]; other site 471854004290 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 471854004291 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854004292 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 471854004293 active site 471854004294 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854004295 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 471854004296 active site 471854004297 Zn binding site [ion binding]; other site 471854004298 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854004299 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854004300 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854004301 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004302 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004303 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004304 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854004305 FecR protein; Region: FecR; pfam04773 471854004306 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854004307 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854004308 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854004309 DNA binding residues [nucleotide binding] 471854004310 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 471854004311 Outer membrane efflux protein; Region: OEP; pfam02321 471854004312 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854004313 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 471854004314 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854004315 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 471854004316 Uncharacterized conserved protein [Function unknown]; Region: COG4095 471854004317 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 471854004318 Fn3 associated; Region: Fn3_assoc; pfam13287 471854004319 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 471854004320 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 471854004321 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 471854004322 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 471854004323 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471854004324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471854004325 DNA-binding site [nucleotide binding]; DNA binding site 471854004326 UTRA domain; Region: UTRA; pfam07702 471854004327 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854004328 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854004329 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471854004330 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 471854004331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854004332 putative substrate translocation pore; other site 471854004333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854004334 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471854004335 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 471854004336 putative substrate binding site [chemical binding]; other site 471854004337 putative ATP binding site [chemical binding]; other site 471854004338 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004339 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004340 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004341 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854004342 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854004343 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854004344 SusD family; Region: SusD; pfam07980 471854004345 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 471854004346 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 471854004347 substrate binding [chemical binding]; other site 471854004348 active site 471854004349 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 471854004350 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 471854004351 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 471854004352 putative ligand binding site [chemical binding]; other site 471854004353 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854004354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854004355 dimer interface [polypeptide binding]; other site 471854004356 phosphorylation site [posttranslational modification] 471854004357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854004358 ATP binding site [chemical binding]; other site 471854004359 Mg2+ binding site [ion binding]; other site 471854004360 G-X-G motif; other site 471854004361 Response regulator receiver domain; Region: Response_reg; pfam00072 471854004362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854004363 active site 471854004364 phosphorylation site [posttranslational modification] 471854004365 intermolecular recognition site; other site 471854004366 dimerization interface [polypeptide binding]; other site 471854004367 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471854004368 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854004369 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854004370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854004371 binding surface 471854004372 TPR motif; other site 471854004373 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854004374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854004375 dimer interface [polypeptide binding]; other site 471854004376 phosphorylation site [posttranslational modification] 471854004377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854004378 ATP binding site [chemical binding]; other site 471854004379 Mg2+ binding site [ion binding]; other site 471854004380 G-X-G motif; other site 471854004381 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 471854004382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854004383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854004384 dimer interface [polypeptide binding]; other site 471854004385 phosphorylation site [posttranslational modification] 471854004386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854004387 ATP binding site [chemical binding]; other site 471854004388 Mg2+ binding site [ion binding]; other site 471854004389 G-X-G motif; other site 471854004390 Response regulator receiver domain; Region: Response_reg; pfam00072 471854004391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854004392 active site 471854004393 phosphorylation site [posttranslational modification] 471854004394 intermolecular recognition site; other site 471854004395 dimerization interface [polypeptide binding]; other site 471854004396 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854004397 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854004398 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 471854004399 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 471854004400 active site 471854004401 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471854004402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854004403 S-adenosylmethionine binding site [chemical binding]; other site 471854004404 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 471854004405 Trp docking motif [polypeptide binding]; other site 471854004406 PQQ-like domain; Region: PQQ_2; pfam13360 471854004407 putative active site [active] 471854004408 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471854004409 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 471854004410 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 471854004411 RibD C-terminal domain; Region: RibD_C; cl17279 471854004412 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471854004413 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 471854004414 Galactose oxidase, central domain; Region: Kelch_3; cl02701 471854004415 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 471854004416 Moco binding site; other site 471854004417 metal coordination site [ion binding]; other site 471854004418 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 471854004419 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854004420 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854004421 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004422 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004423 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004424 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854004425 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 471854004426 proposed catalytic triad [active] 471854004427 active site nucleophile [active] 471854004428 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854004429 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854004430 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854004431 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004432 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004433 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854004434 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854004435 FecR protein; Region: FecR; pfam04773 471854004436 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854004437 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854004438 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854004439 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854004440 DNA binding residues [nucleotide binding] 471854004441 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 471854004442 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 471854004443 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 471854004444 active site 471854004445 PQQ-like domain; Region: PQQ_2; pfam13360 471854004446 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 471854004447 PQQ-like domain; Region: PQQ_2; pfam13360 471854004448 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 471854004449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 471854004450 Histidine kinase; Region: HisKA_2; pfam07568 471854004451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854004452 ATP binding site [chemical binding]; other site 471854004453 Mg2+ binding site [ion binding]; other site 471854004454 G-X-G motif; other site 471854004455 Response regulator receiver domain; Region: Response_reg; pfam00072 471854004456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854004457 active site 471854004458 phosphorylation site [posttranslational modification] 471854004459 intermolecular recognition site; other site 471854004460 dimerization interface [polypeptide binding]; other site 471854004461 LytTr DNA-binding domain; Region: LytTR; smart00850 471854004462 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 471854004463 Interdomain contacts; other site 471854004464 Cytokine receptor motif; other site 471854004465 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471854004466 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 471854004467 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 471854004468 Cytochrome P450; Region: p450; cl12078 471854004469 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 471854004470 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 471854004471 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471854004472 Sulfatase; Region: Sulfatase; pfam00884 471854004473 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854004474 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854004475 SusD family; Region: SusD; pfam07980 471854004476 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004477 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004478 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004479 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854004480 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 471854004481 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 471854004482 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 471854004483 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 471854004484 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 471854004485 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 471854004486 putative ligand binding site [chemical binding]; other site 471854004487 putative NAD binding site [chemical binding]; other site 471854004488 catalytic site [active] 471854004489 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854004490 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854004491 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 471854004492 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 471854004493 Sulfate transporter family; Region: Sulfate_transp; pfam00916 471854004494 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 471854004495 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854004496 FtsX-like permease family; Region: FtsX; pfam02687 471854004497 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854004498 FtsX-like permease family; Region: FtsX; pfam02687 471854004499 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471854004500 Ligand Binding Site [chemical binding]; other site 471854004501 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471854004502 Ligand Binding Site [chemical binding]; other site 471854004503 GLPGLI family protein; Region: GLPGLI; TIGR01200 471854004504 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854004505 Family description; Region: VCBS; pfam13517 471854004506 Family description; Region: VCBS; pfam13517 471854004507 Family description; Region: VCBS; pfam13517 471854004508 Family description; Region: VCBS; pfam13517 471854004509 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854004510 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854004511 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854004512 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004513 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004514 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004515 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854004516 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854004517 FecR protein; Region: FecR; pfam04773 471854004518 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854004519 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854004520 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854004521 DNA binding residues [nucleotide binding] 471854004522 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854004523 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854004524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854004525 ATP binding site [chemical binding]; other site 471854004526 Mg2+ binding site [ion binding]; other site 471854004527 G-X-G motif; other site 471854004528 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854004529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854004530 active site 471854004531 phosphorylation site [posttranslational modification] 471854004532 intermolecular recognition site; other site 471854004533 dimerization interface [polypeptide binding]; other site 471854004534 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854004535 DNA binding residues [nucleotide binding] 471854004536 dimerization interface [polypeptide binding]; other site 471854004537 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 471854004538 ApbE family; Region: ApbE; pfam02424 471854004539 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 471854004540 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 471854004541 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 471854004542 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 471854004543 Flavodoxin; Region: Flavodoxin_1; pfam00258 471854004544 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 471854004545 FAD binding pocket [chemical binding]; other site 471854004546 conserved FAD binding motif [chemical binding]; other site 471854004547 phosphate binding motif [ion binding]; other site 471854004548 beta-alpha-beta structure motif; other site 471854004549 NAD binding pocket [chemical binding]; other site 471854004550 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 471854004551 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471854004552 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471854004553 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471854004554 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471854004555 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471854004556 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471854004557 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471854004558 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471854004559 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 471854004560 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004561 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854004562 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854004563 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854004564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854004565 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 471854004566 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 471854004567 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 471854004568 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471854004569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854004570 ATP binding site [chemical binding]; other site 471854004571 Mg2+ binding site [ion binding]; other site 471854004572 G-X-G motif; other site 471854004573 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471854004574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854004575 ATP binding site [chemical binding]; other site 471854004576 Mg2+ binding site [ion binding]; other site 471854004577 G-X-G motif; other site 471854004578 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 471854004579 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854004580 PAS domain; Region: PAS_9; pfam13426 471854004581 putative active site [active] 471854004582 heme pocket [chemical binding]; other site 471854004583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854004584 dimer interface [polypeptide binding]; other site 471854004585 phosphorylation site [posttranslational modification] 471854004586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854004587 ATP binding site [chemical binding]; other site 471854004588 Mg2+ binding site [ion binding]; other site 471854004589 G-X-G motif; other site 471854004590 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471854004591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854004592 active site 471854004593 phosphorylation site [posttranslational modification] 471854004594 intermolecular recognition site; other site 471854004595 dimerization interface [polypeptide binding]; other site 471854004596 NADH dehydrogenase subunit G; Validated; Region: PRK07860 471854004597 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 471854004598 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 471854004599 dimanganese center [ion binding]; other site 471854004600 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 471854004601 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004602 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004603 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004604 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 471854004605 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854004606 SusD family; Region: SusD; pfam07980 471854004607 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 471854004608 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471854004609 ligand binding site [chemical binding]; other site 471854004610 Vitamin K epoxide reductase (VKOR) family in bacteria; Region: VKOR_4; cd12921 471854004611 putative active site [active] 471854004612 redox center [active] 471854004613 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 471854004614 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 471854004615 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 471854004616 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 471854004617 putative active site [active] 471854004618 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471854004619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854004620 Walker A/P-loop; other site 471854004621 ATP binding site [chemical binding]; other site 471854004622 Q-loop/lid; other site 471854004623 ABC transporter signature motif; other site 471854004624 Walker B; other site 471854004625 D-loop; other site 471854004626 H-loop/switch region; other site 471854004627 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854004628 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 471854004629 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854004630 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 471854004631 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 471854004632 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 471854004633 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 471854004634 Catalytic dyad [active] 471854004635 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854004636 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471854004637 Histidine kinase; Region: HisKA_3; pfam07730 471854004638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854004639 ATP binding site [chemical binding]; other site 471854004640 Mg2+ binding site [ion binding]; other site 471854004641 G-X-G motif; other site 471854004642 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854004643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854004644 active site 471854004645 phosphorylation site [posttranslational modification] 471854004646 intermolecular recognition site; other site 471854004647 dimerization interface [polypeptide binding]; other site 471854004648 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854004649 DNA binding residues [nucleotide binding] 471854004650 dimerization interface [polypeptide binding]; other site 471854004651 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471854004652 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 471854004653 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 471854004654 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854004655 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854004656 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004657 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004658 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004659 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854004660 FecR protein; Region: FecR; pfam04773 471854004661 RNA polymerase sigma factor; Provisional; Region: PRK11924 471854004662 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854004663 DNA binding residues [nucleotide binding] 471854004664 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 471854004665 intersubunit interface [polypeptide binding]; other site 471854004666 active site 471854004667 zinc binding site [ion binding]; other site 471854004668 Na+ binding site [ion binding]; other site 471854004669 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471854004670 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 471854004671 substrate binding site [chemical binding]; other site 471854004672 ATP binding site [chemical binding]; other site 471854004673 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 471854004674 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471854004675 dimer interface [polypeptide binding]; other site 471854004676 active site 471854004677 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 471854004678 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 471854004679 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471854004680 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854004681 UDP-galactose transporter; Region: nst; TIGR00803 471854004682 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 471854004683 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 471854004684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854004685 binding surface 471854004686 TPR motif; other site 471854004687 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854004688 binding surface 471854004689 TPR motif; other site 471854004690 TPR repeat; Region: TPR_11; pfam13414 471854004691 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854004692 binding surface 471854004693 TPR motif; other site 471854004694 Putative esterase; Region: Esterase; pfam00756 471854004695 ACT domain; Region: ACT_5; pfam13710 471854004696 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471854004697 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 471854004698 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 471854004699 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 471854004700 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854004701 non-specific DNA binding site [nucleotide binding]; other site 471854004702 salt bridge; other site 471854004703 sequence-specific DNA binding site [nucleotide binding]; other site 471854004704 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471854004705 active site 471854004706 NTP binding site [chemical binding]; other site 471854004707 metal binding triad [ion binding]; metal-binding site 471854004708 antibiotic binding site [chemical binding]; other site 471854004709 Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748 471854004710 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 471854004711 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004712 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004713 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854004714 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854004715 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854004716 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854004717 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 471854004718 active site 471854004719 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 471854004720 active site 471854004721 PQQ-like domain; Region: PQQ_2; pfam13360 471854004722 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 471854004723 Trp docking motif [polypeptide binding]; other site 471854004724 active site 471854004725 PQQ-like domain; Region: PQQ_2; pfam13360 471854004726 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854004727 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854004728 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471854004729 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854004730 FecR protein; Region: FecR; pfam04773 471854004731 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004732 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 471854004733 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 471854004734 N-terminal plug; other site 471854004735 ligand-binding site [chemical binding]; other site 471854004736 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 471854004737 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 471854004738 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 471854004739 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 471854004740 PQQ-like domain; Region: PQQ_2; pfam13360 471854004741 FOG: WD40-like repeat [Function unknown]; Region: COG1520 471854004742 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 471854004743 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 471854004744 conserved cys residue [active] 471854004745 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854004746 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854004747 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854004748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854004749 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854004750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854004751 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854004752 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 471854004753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854004754 Walker B motif; other site 471854004755 arginine finger; other site 471854004756 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 471854004757 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 471854004758 substrate binding pocket [chemical binding]; other site 471854004759 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854004760 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471854004761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854004762 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471854004763 Walker A motif; other site 471854004764 ATP binding site [chemical binding]; other site 471854004765 Walker B motif; other site 471854004766 arginine finger; other site 471854004767 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 471854004768 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854004769 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854004770 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854004771 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004772 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004773 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004774 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854004775 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854004776 FecR protein; Region: FecR; pfam04773 471854004777 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854004778 RNA polymerase factor sigma-70; Validated; Region: PRK09047 471854004779 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854004780 DNA binding residues [nucleotide binding] 471854004781 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 471854004782 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854004783 PAS fold; Region: PAS_4; pfam08448 471854004784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854004785 PAS fold; Region: PAS_3; pfam08447 471854004786 putative active site [active] 471854004787 heme pocket [chemical binding]; other site 471854004788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854004789 dimer interface [polypeptide binding]; other site 471854004790 phosphorylation site [posttranslational modification] 471854004791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854004792 ATP binding site [chemical binding]; other site 471854004793 Mg2+ binding site [ion binding]; other site 471854004794 G-X-G motif; other site 471854004795 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 471854004796 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 471854004797 PhnA protein; Region: PhnA; pfam03831 471854004798 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 471854004799 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854004800 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854004801 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 471854004802 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854004803 FtsX-like permease family; Region: FtsX; pfam02687 471854004804 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471854004805 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854004806 FtsX-like permease family; Region: FtsX; pfam02687 471854004807 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 471854004808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854004809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854004810 dimer interface [polypeptide binding]; other site 471854004811 phosphorylation site [posttranslational modification] 471854004812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854004813 ATP binding site [chemical binding]; other site 471854004814 Mg2+ binding site [ion binding]; other site 471854004815 G-X-G motif; other site 471854004816 Response regulator receiver domain; Region: Response_reg; pfam00072 471854004817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854004818 active site 471854004819 phosphorylation site [posttranslational modification] 471854004820 intermolecular recognition site; other site 471854004821 dimerization interface [polypeptide binding]; other site 471854004822 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854004823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854004824 Protein of unknown function (DUF808); Region: DUF808; cl01002 471854004825 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 471854004826 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 471854004827 Bacterial Ig-like domain; Region: Big_5; pfam13205 471854004828 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 471854004829 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854004830 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854004831 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854004832 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854004833 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854004834 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854004835 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 471854004836 DNA-binding interface [nucleotide binding]; DNA binding site 471854004837 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854004838 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 471854004839 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 471854004840 N-terminal plug; other site 471854004841 ligand-binding site [chemical binding]; other site 471854004842 SnoaL-like domain; Region: SnoaL_3; pfam13474 471854004843 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 471854004844 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471854004845 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471854004846 ligand binding site [chemical binding]; other site 471854004847 flexible hinge region; other site 471854004848 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471854004849 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471854004850 active site 471854004851 catalytic site [active] 471854004852 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854004853 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854004854 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854004855 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004856 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004857 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004858 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854004859 FecR protein; Region: FecR; pfam04773 471854004860 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854004861 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854004862 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854004863 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854004864 DNA binding residues [nucleotide binding] 471854004865 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471854004866 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471854004867 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471854004868 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471854004869 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 471854004870 ligand binding site [chemical binding]; other site 471854004871 flexible hinge region; other site 471854004872 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 471854004873 DNA-binding interface [nucleotide binding]; DNA binding site 471854004874 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471854004875 homotrimer interaction site [polypeptide binding]; other site 471854004876 putative active site [active] 471854004877 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004878 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004879 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004880 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854004881 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854004882 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854004883 SusD family; Region: SusD; pfam07980 471854004884 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471854004885 Sulfatase; Region: Sulfatase; cl17466 471854004886 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471854004887 Sulfatase; Region: Sulfatase; pfam00884 471854004888 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004889 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004890 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004891 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854004892 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854004893 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854004894 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471854004895 Sulfatase; Region: Sulfatase; pfam00884 471854004896 Erythromycin esterase; Region: Erythro_esteras; pfam05139 471854004897 Predicted transcriptional regulators [Transcription]; Region: COG1733 471854004898 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471854004899 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471854004900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471854004901 RibD C-terminal domain; Region: RibD_C; cl17279 471854004902 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471854004903 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 471854004904 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471854004905 Cytochrome c; Region: Cytochrom_C; pfam00034 471854004906 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 471854004907 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471854004908 catalytic residue [active] 471854004909 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854004910 SusD family; Region: SusD; pfam07980 471854004911 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854004912 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004913 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004914 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004915 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854004916 FecR protein; Region: FecR; pfam04773 471854004917 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854004918 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854004919 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471854004920 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 471854004921 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471854004922 ligand binding site [chemical binding]; other site 471854004923 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471854004924 Beta-lactamase; Region: Beta-lactamase; pfam00144 471854004925 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471854004926 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471854004927 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 471854004928 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 471854004929 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 471854004930 tetramer interface [polypeptide binding]; other site 471854004931 heme binding pocket [chemical binding]; other site 471854004932 NADPH binding site [chemical binding]; other site 471854004933 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854004934 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854004935 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854004936 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854004937 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854004938 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854004939 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471854004940 FtsX-like permease family; Region: FtsX; pfam02687 471854004941 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471854004942 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854004943 FtsX-like permease family; Region: FtsX; pfam02687 471854004944 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 471854004945 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854004946 FtsX-like permease family; Region: FtsX; pfam02687 471854004947 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854004948 FtsX-like permease family; Region: FtsX; pfam02687 471854004949 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471854004950 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471854004951 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 471854004952 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471854004953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854004954 active site 471854004955 phosphorylation site [posttranslational modification] 471854004956 intermolecular recognition site; other site 471854004957 dimerization interface [polypeptide binding]; other site 471854004958 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471854004959 DNA binding site [nucleotide binding] 471854004960 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854004961 HAMP domain; Region: HAMP; pfam00672 471854004962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854004963 dimer interface [polypeptide binding]; other site 471854004964 phosphorylation site [posttranslational modification] 471854004965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854004966 ATP binding site [chemical binding]; other site 471854004967 Mg2+ binding site [ion binding]; other site 471854004968 G-X-G motif; other site 471854004969 Outer membrane efflux protein; Region: OEP; pfam02321 471854004970 Outer membrane efflux protein; Region: OEP; pfam02321 471854004971 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854004972 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854004973 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 471854004974 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 471854004975 Uncharacterized conserved protein [Function unknown]; Region: COG1359 471854004976 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 471854004977 Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; Region: Jacalin_ZG16_like; cd09611 471854004978 putative sugar binding site [chemical binding]; other site 471854004979 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 471854004980 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854004981 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854004982 DNA binding residues [nucleotide binding] 471854004983 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 471854004984 Fasciclin domain; Region: Fasciclin; pfam02469 471854004985 Fasciclin domain; Region: Fasciclin; pfam02469 471854004986 hypothetical protein; Provisional; Region: PRK09897 471854004987 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 471854004988 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 471854004989 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 471854004990 MOSC domain; Region: MOSC; pfam03473 471854004991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854004992 Response regulator receiver domain; Region: Response_reg; pfam00072 471854004993 active site 471854004994 phosphorylation site [posttranslational modification] 471854004995 intermolecular recognition site; other site 471854004996 dimerization interface [polypeptide binding]; other site 471854004997 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471854004998 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 471854004999 putative NAD(P) binding site [chemical binding]; other site 471854005000 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 471854005001 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471854005002 Beta-lactamase; Region: Beta-lactamase; pfam00144 471854005003 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471854005004 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 471854005005 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471854005006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854005007 NAD(P) binding site [chemical binding]; other site 471854005008 active site 471854005009 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854005010 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854005011 BCCT family transporter; Region: BCCT; pfam02028 471854005012 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 471854005013 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 471854005014 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 471854005015 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 471854005016 active site 471854005017 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 471854005018 Right handed beta helix region; Region: Beta_helix; pfam13229 471854005019 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 471854005020 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854005021 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854005022 SusD family; Region: SusD; pfam07980 471854005023 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854005024 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854005025 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854005026 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854005027 FecR protein; Region: FecR; pfam04773 471854005028 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854005029 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854005030 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854005031 DNA binding residues [nucleotide binding] 471854005032 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854005033 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854005034 SusD family; Region: SusD; pfam07980 471854005035 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854005036 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854005037 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854005038 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854005039 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854005040 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854005041 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 471854005042 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 471854005043 Ca binding site [ion binding]; other site 471854005044 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854005045 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854005046 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854005047 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854005048 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854005049 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854005050 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854005051 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 471854005052 putative transporter; Provisional; Region: PRK10484 471854005053 Na binding site [ion binding]; other site 471854005054 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471854005055 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 471854005056 metal binding site [ion binding]; metal-binding site 471854005057 substrate binding pocket [chemical binding]; other site 471854005058 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 471854005059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854005060 NAD(P) binding site [chemical binding]; other site 471854005061 active site 471854005062 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 471854005063 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854005064 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854005065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854005066 Coenzyme A binding pocket [chemical binding]; other site 471854005067 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471854005068 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471854005069 Cupin domain; Region: Cupin_2; pfam07883 471854005070 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854005071 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854005072 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854005073 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854005074 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471854005075 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 471854005076 GIY-YIG motif/motif A; other site 471854005077 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471854005078 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471854005079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854005080 Coenzyme A binding pocket [chemical binding]; other site 471854005081 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471854005082 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471854005083 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 471854005084 Integrase core domain; Region: rve; pfam00665 471854005085 DDE domain; Region: DDE_Tnp_IS240; pfam13610 471854005086 Integrase core domain; Region: rve_3; pfam13683 471854005087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 471854005088 Integrase core domain; Region: rve; pfam00665 471854005089 Integrase core domain; Region: rve_3; pfam13683 471854005090 Transposase; Region: HTH_Tnp_1; cl17663 471854005091 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471854005092 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854005093 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 471854005094 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854005095 active site 471854005096 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 471854005097 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471854005098 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471854005099 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 471854005100 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471854005101 inhibitor-cofactor binding pocket; inhibition site 471854005102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854005103 catalytic residue [active] 471854005104 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08269 471854005105 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471854005106 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471854005107 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471854005108 homotrimer interaction site [polypeptide binding]; other site 471854005109 putative active site [active] 471854005110 flagellin modification protein A; Provisional; Region: PRK09186 471854005111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854005112 NAD(P) binding site [chemical binding]; other site 471854005113 active site 471854005114 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854005115 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854005116 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471854005117 active site 471854005118 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471854005119 catalytic tetrad [active] 471854005120 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 471854005121 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471854005122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854005123 NAD(P) binding site [chemical binding]; other site 471854005124 active site 471854005125 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 471854005126 Asp-box motif; other site 471854005127 BNR repeat-like domain; Region: BNR_2; pfam13088 471854005128 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 471854005129 Asp-box motif; other site 471854005130 catalytic site [active] 471854005131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854005132 putative substrate translocation pore; other site 471854005133 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471854005134 BNR repeat-like domain; Region: BNR_2; pfam13088 471854005135 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 471854005136 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854005137 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854005138 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854005139 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854005140 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854005141 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854005142 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854005143 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471854005144 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854005145 Baculovirus gp64 envelope glycoprotein family; Region: Baculo_gp64; pfam03273 471854005146 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 471854005147 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 471854005148 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471854005149 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 471854005150 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 471854005151 FAD binding pocket [chemical binding]; other site 471854005152 FAD binding motif [chemical binding]; other site 471854005153 phosphate binding motif [ion binding]; other site 471854005154 beta-alpha-beta structure motif; other site 471854005155 NAD binding pocket [chemical binding]; other site 471854005156 Heme binding pocket [chemical binding]; other site 471854005157 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471854005158 catalytic loop [active] 471854005159 iron binding site [ion binding]; other site 471854005160 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471854005161 nucleoside/Zn binding site; other site 471854005162 dimer interface [polypeptide binding]; other site 471854005163 catalytic motif [active] 471854005164 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854005165 Right handed beta helix region; Region: Beta_helix; pfam13229 471854005166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471854005167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471854005168 Cupin domain; Region: Cupin_2; pfam07883 471854005169 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 471854005170 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471854005171 active site 471854005172 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 471854005173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854005174 Coenzyme A binding pocket [chemical binding]; other site 471854005175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471854005176 dimerization interface [polypeptide binding]; other site 471854005177 putative DNA binding site [nucleotide binding]; other site 471854005178 putative Zn2+ binding site [ion binding]; other site 471854005179 DNA topoisomerase 2-like protein; Provisional; Region: PTZ00108 471854005180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 471854005181 HTH-like domain; Region: HTH_21; pfam13276 471854005182 Integrase core domain; Region: rve; pfam00665 471854005183 Integrase core domain; Region: rve_3; pfam13683 471854005184 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471854005185 Gram-negative bacterial tonB protein; Region: TonB; cl10048 471854005186 short chain dehydrogenase; Provisional; Region: PRK06500 471854005187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854005188 NAD(P) binding site [chemical binding]; other site 471854005189 active site 471854005190 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 471854005191 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 471854005192 active site 471854005193 TDP-binding site; other site 471854005194 acceptor substrate-binding pocket; other site 471854005195 short chain dehydrogenase; Provisional; Region: PRK06500 471854005196 classical (c) SDRs; Region: SDR_c; cd05233 471854005197 NAD(P) binding site [chemical binding]; other site 471854005198 active site 471854005199 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854005200 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471854005201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854005202 S-adenosylmethionine binding site [chemical binding]; other site 471854005203 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 471854005204 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 471854005205 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 471854005206 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854005207 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 471854005208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854005209 ATP binding site [chemical binding]; other site 471854005210 Mg2+ binding site [ion binding]; other site 471854005211 G-X-G motif; other site 471854005212 Response regulator receiver domain; Region: Response_reg; pfam00072 471854005213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854005214 active site 471854005215 phosphorylation site [posttranslational modification] 471854005216 intermolecular recognition site; other site 471854005217 dimerization interface [polypeptide binding]; other site 471854005218 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854005219 Response regulator receiver domain; Region: Response_reg; pfam00072 471854005220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854005221 active site 471854005222 phosphorylation site [posttranslational modification] 471854005223 intermolecular recognition site; other site 471854005224 dimerization interface [polypeptide binding]; other site 471854005225 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471854005226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854005227 Winged helix-turn helix; Region: HTH_29; pfam13551 471854005228 Helix-turn-helix domain; Region: HTH_28; pfam13518 471854005229 Homeodomain-like domain; Region: HTH_32; pfam13565 471854005230 Integrase core domain; Region: rve; pfam00665 471854005231 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 471854005232 Integrase core domain; Region: rve_3; pfam13683 471854005233 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 471854005234 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 471854005235 dimer interface [polypeptide binding]; other site 471854005236 active site 471854005237 ADP-ribose binding site [chemical binding]; other site 471854005238 nudix motif; other site 471854005239 metal binding site [ion binding]; metal-binding site 471854005240 glycogen branching enzyme; Provisional; Region: PRK12313 471854005241 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 471854005242 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 471854005243 active site 471854005244 catalytic site [active] 471854005245 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 471854005246 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 471854005247 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 471854005248 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471854005249 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 471854005250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471854005251 DinB superfamily; Region: DinB_2; pfam12867 471854005252 DinB family; Region: DinB; cl17821 471854005253 Methyltransferase domain; Region: Methyltransf_24; pfam13578 471854005254 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854005255 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 471854005256 putative dimer interface [polypeptide binding]; other site 471854005257 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854005258 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 471854005259 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471854005260 active site 471854005261 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 471854005262 Peptidase family M1; Region: Peptidase_M1; pfam01433 471854005263 Zn binding site [ion binding]; other site 471854005264 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 471854005265 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854005266 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854005267 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 471854005268 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471854005269 classical (c) SDRs; Region: SDR_c; cd05233 471854005270 NAD(P) binding site [chemical binding]; other site 471854005271 active site 471854005272 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 471854005273 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 471854005274 dimerization interface [polypeptide binding]; other site 471854005275 putative active cleft [active] 471854005276 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 471854005277 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 471854005278 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 471854005279 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 471854005280 Fn3 associated; Region: Fn3_assoc; pfam13287 471854005281 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 471854005282 Protein of unknown function (DUF2540); Region: DUF2540; pfam10802 471854005283 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 471854005284 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 471854005285 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 471854005286 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 471854005287 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471854005288 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 471854005289 substrate binding site [chemical binding]; other site 471854005290 dimer interface [polypeptide binding]; other site 471854005291 ATP binding site [chemical binding]; other site 471854005292 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 471854005293 active site 471854005294 tetramer interface [polypeptide binding]; other site 471854005295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854005296 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 471854005297 putative substrate translocation pore; other site 471854005298 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 471854005299 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 471854005300 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854005301 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 471854005302 Ligand binding site; other site 471854005303 Putative Catalytic site; other site 471854005304 DXD motif; other site 471854005305 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 471854005306 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471854005307 active site 2 [active] 471854005308 active site 1 [active] 471854005309 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 471854005310 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 471854005311 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 471854005312 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 471854005313 NodB motif; other site 471854005314 active site 471854005315 catalytic site [active] 471854005316 metal binding site [ion binding]; metal-binding site 471854005317 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 471854005318 active site 471854005319 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 471854005320 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471854005321 dimer interface [polypeptide binding]; other site 471854005322 active site 471854005323 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471854005324 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 471854005325 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 471854005326 active site 471854005327 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 471854005328 active site 471854005329 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471854005330 active site 1 [active] 471854005331 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 471854005332 putative acyl-acceptor binding pocket; other site 471854005333 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 471854005334 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471854005335 dimer interface [polypeptide binding]; other site 471854005336 active site 471854005337 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 471854005338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854005339 NAD(P) binding site [chemical binding]; other site 471854005340 active site 471854005341 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 471854005342 active sites [active] 471854005343 tetramer interface [polypeptide binding]; other site 471854005344 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471854005345 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471854005346 putative acyl-acceptor binding pocket; other site 471854005347 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471854005348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854005349 S-adenosylmethionine binding site [chemical binding]; other site 471854005350 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 471854005351 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471854005352 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 471854005353 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471854005354 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 471854005355 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 471854005356 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 471854005357 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471854005358 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 471854005359 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 471854005360 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 471854005361 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 471854005362 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 471854005363 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 471854005364 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 471854005365 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471854005366 catalytic residue [active] 471854005367 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 471854005368 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 471854005369 putative active site [active] 471854005370 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 471854005371 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 471854005372 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 471854005373 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471854005374 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471854005375 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 471854005376 Domain of unknown function (DUF814); Region: DUF814; pfam05670 471854005377 K-Cl cotransporter; Region: 2a30; TIGR00930 471854005378 PIN domain; Region: PIN_3; pfam13470 471854005379 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471854005380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854005381 putative substrate translocation pore; other site 471854005382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854005383 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 471854005384 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854005385 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854005386 Outer membrane efflux protein; Region: OEP; pfam02321 471854005387 Outer membrane efflux protein; Region: OEP; pfam02321 471854005388 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471854005389 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471854005390 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 471854005391 active site 471854005392 active site 471854005393 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854005394 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 471854005395 putative DNA-binding cleft [nucleotide binding]; other site 471854005396 dimer interface [polypeptide binding]; other site 471854005397 active site 471854005398 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 471854005399 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471854005400 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_e; cd04192 471854005401 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 471854005402 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854005403 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471854005404 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854005405 non-specific DNA binding site [nucleotide binding]; other site 471854005406 salt bridge; other site 471854005407 sequence-specific DNA binding site [nucleotide binding]; other site 471854005408 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 471854005409 Catalytic site [active] 471854005410 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471854005411 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 471854005412 DNA binding residues [nucleotide binding] 471854005413 B12 binding domain; Region: B12-binding_2; pfam02607 471854005414 phytoene desaturase; Region: crtI_fam; TIGR02734 471854005415 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471854005416 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 471854005417 active site lid residues [active] 471854005418 substrate binding pocket [chemical binding]; other site 471854005419 catalytic residues [active] 471854005420 substrate-Mg2+ binding site; other site 471854005421 aspartate-rich region 1; other site 471854005422 aspartate-rich region 2; other site 471854005423 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 471854005424 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 471854005425 active site 471854005426 metal binding site [ion binding]; metal-binding site 471854005427 nudix motif; other site 471854005428 beta-carotene hydroxylase; Region: PLN02601 471854005429 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 471854005430 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 471854005431 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 471854005432 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471854005433 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 471854005434 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471854005435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854005436 S-adenosylmethionine binding site [chemical binding]; other site 471854005437 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; COG0382 471854005438 UbiA prenyltransferase family; Region: UbiA; pfam01040 471854005439 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 471854005440 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 471854005441 malonyl-CoA binding site [chemical binding]; other site 471854005442 dimer interface [polypeptide binding]; other site 471854005443 active site 471854005444 product binding site; other site 471854005445 serine O-acetyltransferase; Region: cysE; TIGR01172 471854005446 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 471854005447 trimer interface [polypeptide binding]; other site 471854005448 active site 471854005449 substrate binding site [chemical binding]; other site 471854005450 CoA binding site [chemical binding]; other site 471854005451 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471854005452 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 471854005453 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471854005454 catalytic residue [active] 471854005455 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 471854005456 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 471854005457 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471854005458 putative DNA binding site [nucleotide binding]; other site 471854005459 dimerization interface [polypeptide binding]; other site 471854005460 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471854005461 putative Zn2+ binding site [ion binding]; other site 471854005462 AsnC family; Region: AsnC_trans_reg; pfam01037 471854005463 EamA-like transporter family; Region: EamA; pfam00892 471854005464 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471854005465 EamA-like transporter family; Region: EamA; pfam00892 471854005466 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 471854005467 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854005468 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854005469 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 471854005470 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 471854005471 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471854005472 catalytic residue [active] 471854005473 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854005474 Family description; Region: VCBS; pfam13517 471854005475 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854005476 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854005477 Family description; Region: VCBS; pfam13517 471854005478 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854005479 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854005480 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854005481 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854005482 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854005483 Family description; Region: VCBS; pfam13517 471854005484 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854005485 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854005486 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854005487 Family description; Region: VCBS; pfam13517 471854005488 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854005489 Family description; Region: VCBS; pfam13517 471854005490 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854005491 Family description; Region: VCBS; pfam13517 471854005492 FG-GAP repeat; Region: FG-GAP; cl15299 471854005493 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854005494 Sulfatase; Region: Sulfatase; cl17466 471854005495 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471854005496 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471854005497 Sulfatase; Region: Sulfatase; pfam00884 471854005498 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471854005499 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854005500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854005501 active site 471854005502 phosphorylation site [posttranslational modification] 471854005503 intermolecular recognition site; other site 471854005504 dimerization interface [polypeptide binding]; other site 471854005505 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854005506 DNA binding residues [nucleotide binding] 471854005507 dimerization interface [polypeptide binding]; other site 471854005508 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 471854005509 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471854005510 Histidine kinase; Region: HisKA_3; pfam07730 471854005511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854005512 ATP binding site [chemical binding]; other site 471854005513 Mg2+ binding site [ion binding]; other site 471854005514 G-X-G motif; other site 471854005515 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 471854005516 nitrite reductase subunit NirD; Provisional; Region: PRK14989 471854005517 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471854005518 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471854005519 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 471854005520 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 471854005521 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471854005522 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 471854005523 active site 471854005524 SAM binding site [chemical binding]; other site 471854005525 homodimer interface [polypeptide binding]; other site 471854005526 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 471854005527 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 471854005528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854005529 putative substrate translocation pore; other site 471854005530 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 471854005531 [4Fe-4S] binding site [ion binding]; other site 471854005532 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 471854005533 molybdopterin cofactor binding site; other site 471854005534 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 471854005535 molybdopterin cofactor binding site; other site 471854005536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 471854005537 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471854005538 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 471854005539 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 471854005540 Rubredoxin; Region: Rubredoxin; pfam00301 471854005541 iron binding site [ion binding]; other site 471854005542 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 471854005543 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471854005544 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471854005545 catalytic residues [active] 471854005546 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471854005547 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471854005548 active site 471854005549 metal binding site [ion binding]; metal-binding site 471854005550 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854005551 Peptidase family M1; Region: Peptidase_M1; pfam01433 471854005552 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 471854005553 Zn binding site [ion binding]; other site 471854005554 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 471854005555 TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes:...; Region: TBP_TLF; cl08263 471854005556 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 471854005557 Predicted transcriptional regulators [Transcription]; Region: COG1733 471854005558 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471854005559 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 471854005560 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 471854005561 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 471854005562 active site 471854005563 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854005564 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471854005565 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471854005566 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471854005567 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471854005568 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471854005569 trehalose synthase; Region: treS_nterm; TIGR02456 471854005570 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 471854005571 active site 471854005572 catalytic site [active] 471854005573 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 471854005574 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854005575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854005576 active site 471854005577 phosphorylation site [posttranslational modification] 471854005578 intermolecular recognition site; other site 471854005579 dimerization interface [polypeptide binding]; other site 471854005580 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854005581 DNA binding residues [nucleotide binding] 471854005582 dimerization interface [polypeptide binding]; other site 471854005583 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854005584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 471854005585 dimer interface [polypeptide binding]; other site 471854005586 phosphorylation site [posttranslational modification] 471854005587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854005588 ATP binding site [chemical binding]; other site 471854005589 Mg2+ binding site [ion binding]; other site 471854005590 G-X-G motif; other site 471854005591 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854005592 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471854005593 FtsX-like permease family; Region: FtsX; pfam02687 471854005594 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471854005595 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854005596 FtsX-like permease family; Region: FtsX; pfam02687 471854005597 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 471854005598 Protein of unknown function DUF58; Region: DUF58; pfam01882 471854005599 MoxR-like ATPases [General function prediction only]; Region: COG0714 471854005600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854005601 Walker A motif; other site 471854005602 ATP binding site [chemical binding]; other site 471854005603 Walker B motif; other site 471854005604 arginine finger; other site 471854005605 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 471854005606 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 471854005607 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 471854005608 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 471854005609 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 471854005610 Response regulator receiver domain; Region: Response_reg; pfam00072 471854005611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854005612 active site 471854005613 phosphorylation site [posttranslational modification] 471854005614 intermolecular recognition site; other site 471854005615 dimerization interface [polypeptide binding]; other site 471854005616 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854005617 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 471854005618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854005619 putative substrate translocation pore; other site 471854005620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854005621 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 471854005622 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 471854005623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854005624 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854005625 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854005626 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 471854005627 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 471854005628 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854005629 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 471854005630 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 471854005631 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 471854005632 dimer interface [polypeptide binding]; other site 471854005633 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 471854005634 active site 471854005635 Fe binding site [ion binding]; other site 471854005636 phenylalanine 4-monooxygenase; Reviewed; Region: phhA; PRK11913 471854005637 cofactor binding site; other site 471854005638 metal binding site [ion binding]; metal-binding site 471854005639 fumarylacetoacetase; Region: PLN02856 471854005640 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 471854005641 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 471854005642 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471854005643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471854005644 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 471854005645 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 471854005646 substrate binding site [chemical binding]; other site 471854005647 THF binding site; other site 471854005648 zinc-binding site [ion binding]; other site 471854005649 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854005650 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854005651 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854005652 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854005653 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854005654 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854005655 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854005656 FecR protein; Region: FecR; pfam04773 471854005657 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854005658 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854005659 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854005660 DNA binding residues [nucleotide binding] 471854005661 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 471854005662 active site 471854005663 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854005664 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471854005665 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471854005666 TM-ABC transporter signature motif; other site 471854005667 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 471854005668 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 471854005669 Walker A/P-loop; other site 471854005670 ATP binding site [chemical binding]; other site 471854005671 Q-loop/lid; other site 471854005672 ABC transporter signature motif; other site 471854005673 Walker B; other site 471854005674 D-loop; other site 471854005675 H-loop/switch region; other site 471854005676 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 471854005677 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 471854005678 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 471854005679 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 471854005680 ligand binding site [chemical binding]; other site 471854005681 dimerization interface [polypeptide binding]; other site 471854005682 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 471854005683 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 471854005684 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471854005685 PYR/PP interface [polypeptide binding]; other site 471854005686 dimer interface [polypeptide binding]; other site 471854005687 TPP binding site [chemical binding]; other site 471854005688 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471854005689 transketolase; Reviewed; Region: PRK05899 471854005690 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 471854005691 TPP-binding site [chemical binding]; other site 471854005692 dimer interface [polypeptide binding]; other site 471854005693 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 471854005694 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 471854005695 hexamer (dimer of trimers) interface [polypeptide binding]; other site 471854005696 substrate binding site [chemical binding]; other site 471854005697 trimer interface [polypeptide binding]; other site 471854005698 Mn binding site [ion binding]; other site 471854005699 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471854005700 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471854005701 putative DNA binding site [nucleotide binding]; other site 471854005702 putative Zn2+ binding site [ion binding]; other site 471854005703 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 471854005704 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854005705 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 471854005706 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854005707 sequence-specific DNA binding site [nucleotide binding]; other site 471854005708 salt bridge; other site 471854005709 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 471854005710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 471854005711 BNR repeat-like domain; Region: BNR_2; pfam13088 471854005712 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 471854005713 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 471854005714 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854005715 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854005716 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854005717 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854005718 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854005719 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854005720 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 471854005721 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 471854005722 dimer interface [polypeptide binding]; other site 471854005723 active site 471854005724 catalytic residue [active] 471854005725 metal binding site [ion binding]; metal-binding site 471854005726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 471854005727 bile acid transporter; Region: bass; TIGR00841 471854005728 Sodium Bile acid symporter family; Region: SBF; pfam01758 471854005729 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 471854005730 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 471854005731 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 471854005732 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471854005733 nucleotide binding site [chemical binding]; other site 471854005734 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 471854005735 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854005736 BNR repeat-like domain; Region: BNR_2; pfam13088 471854005737 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 471854005738 catalytic site [active] 471854005739 Asp-box motif; other site 471854005740 Trehalase; Region: Trehalase; cl17346 471854005741 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 471854005742 Pectate lyase; Region: Pec_lyase_C; cl01593 471854005743 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854005744 SusD family; Region: SusD; pfam07980 471854005745 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854005746 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854005747 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854005748 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471854005749 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471854005750 active site 471854005751 metal binding site [ion binding]; metal-binding site 471854005752 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854005753 GAF domain; Region: GAF; pfam01590 471854005754 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471854005755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854005756 ATP binding site [chemical binding]; other site 471854005757 Mg2+ binding site [ion binding]; other site 471854005758 G-X-G motif; other site 471854005759 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 471854005760 putative catalytic site [active] 471854005761 putative phosphate binding site [ion binding]; other site 471854005762 active site 471854005763 metal binding site A [ion binding]; metal-binding site 471854005764 DNA binding site [nucleotide binding] 471854005765 putative AP binding site [nucleotide binding]; other site 471854005766 putative metal binding site B [ion binding]; other site 471854005767 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471854005768 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471854005769 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471854005770 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854005771 Walker A/P-loop; other site 471854005772 ATP binding site [chemical binding]; other site 471854005773 Q-loop/lid; other site 471854005774 ABC transporter signature motif; other site 471854005775 Walker B; other site 471854005776 D-loop; other site 471854005777 H-loop/switch region; other site 471854005778 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471854005779 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471854005780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854005781 Walker A/P-loop; other site 471854005782 ATP binding site [chemical binding]; other site 471854005783 Q-loop/lid; other site 471854005784 ABC transporter signature motif; other site 471854005785 Walker B; other site 471854005786 D-loop; other site 471854005787 H-loop/switch region; other site 471854005788 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471854005789 Sulfatase; Region: Sulfatase; pfam00884 471854005790 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471854005791 extended (e) SDRs; Region: SDR_e; cd08946 471854005792 NAD(P) binding site [chemical binding]; other site 471854005793 active site 471854005794 substrate binding site [chemical binding]; other site 471854005795 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471854005796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854005797 Cation efflux family; Region: Cation_efflux; cl00316 471854005798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 471854005799 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471854005800 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471854005801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471854005802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471854005803 WHG domain; Region: WHG; pfam13305 471854005804 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854005805 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854005806 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854005807 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 471854005808 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 471854005809 HD domain; Region: HD_3; pfam13023 471854005810 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 471854005811 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471854005812 active site 471854005813 dimer interface [polypeptide binding]; other site 471854005814 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 471854005815 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 471854005816 active site 471854005817 FMN binding site [chemical binding]; other site 471854005818 substrate binding site [chemical binding]; other site 471854005819 homotetramer interface [polypeptide binding]; other site 471854005820 catalytic residue [active] 471854005821 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 471854005822 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854005823 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854005824 Rrf2 family protein; Region: rrf2_super; TIGR00738 471854005825 Transcriptional regulator; Region: Rrf2; pfam02082 471854005826 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 471854005827 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 471854005828 heme-binding site [chemical binding]; other site 471854005829 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 471854005830 FAD binding pocket [chemical binding]; other site 471854005831 FAD binding motif [chemical binding]; other site 471854005832 phosphate binding motif [ion binding]; other site 471854005833 beta-alpha-beta structure motif; other site 471854005834 NAD binding pocket [chemical binding]; other site 471854005835 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 471854005836 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 471854005837 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 471854005838 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 471854005839 iron-sulfur cluster [ion binding]; other site 471854005840 [2Fe-2S] cluster binding site [ion binding]; other site 471854005841 Trehalose utilisation; Region: ThuA; pfam06283 471854005842 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471854005843 Cytochrome c; Region: Cytochrom_C; cl11414 471854005844 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 471854005845 ligand binding site [chemical binding]; other site 471854005846 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 471854005847 nudix motif; other site 471854005848 cheY-homologous receiver domain; Region: REC; smart00448 471854005849 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854005850 active site 471854005851 phosphorylation site [posttranslational modification] 471854005852 intermolecular recognition site; other site 471854005853 dimerization interface [polypeptide binding]; other site 471854005854 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854005855 DNA binding residues [nucleotide binding] 471854005856 dimerization interface [polypeptide binding]; other site 471854005857 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854005858 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854005859 DNA binding residues [nucleotide binding] 471854005860 dimerization interface [polypeptide binding]; other site 471854005861 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854005862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854005863 active site 471854005864 phosphorylation site [posttranslational modification] 471854005865 intermolecular recognition site; other site 471854005866 dimerization interface [polypeptide binding]; other site 471854005867 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854005868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854005869 ATP binding site [chemical binding]; other site 471854005870 Mg2+ binding site [ion binding]; other site 471854005871 G-X-G motif; other site 471854005872 Predicted membrane protein [Function unknown]; Region: COG2323 471854005873 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 471854005874 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 471854005875 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854005876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854005877 putative deaminase; Validated; Region: PRK06846 471854005878 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 471854005879 active site 471854005880 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 471854005881 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 471854005882 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 471854005883 Ligand Binding Site [chemical binding]; other site 471854005884 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 471854005885 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 471854005886 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 471854005887 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 471854005888 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 471854005889 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854005890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854005891 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471854005892 DNA binding residues [nucleotide binding] 471854005893 FecR protein; Region: FecR; pfam04773 471854005894 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854005895 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854005896 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854005897 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854005898 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854005899 SusD family; Region: SusD; pfam07980 471854005900 Methyltransferase domain; Region: Methyltransf_24; pfam13578 471854005901 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854005902 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854005903 Predicted membrane protein [Function unknown]; Region: COG3059 471854005904 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 471854005905 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 471854005906 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 471854005907 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 471854005908 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 471854005909 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 471854005910 glutamate dehydrogenase; Provisional; Region: PRK09414 471854005911 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471854005912 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 471854005913 NAD(P) binding site [chemical binding]; other site 471854005914 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 471854005915 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 471854005916 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 471854005917 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 471854005918 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854005919 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854005920 SusD family; Region: SusD; pfam07980 471854005921 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854005922 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854005923 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854005924 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854005925 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854005926 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854005927 FecR protein; Region: FecR; pfam04773 471854005928 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854005929 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854005930 DNA binding residues [nucleotide binding] 471854005931 EthD domain; Region: EthD; cl17553 471854005932 Beta-propeller repeat; Region: SBBP; pfam06739 471854005933 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854005934 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854005935 SusD family; Region: SusD; pfam07980 471854005936 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854005937 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854005938 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854005939 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854005940 FecR protein; Region: FecR; pfam04773 471854005941 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854005942 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854005943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854005944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854005945 DNA binding residues [nucleotide binding] 471854005946 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854005947 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854005948 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854005949 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854005950 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854005951 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471854005952 Sulfatase; Region: Sulfatase; cl17466 471854005953 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471854005954 Sulfatase; Region: Sulfatase; cl17466 471854005955 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471854005956 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471854005957 DNA-binding site [nucleotide binding]; DNA binding site 471854005958 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471854005959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854005960 homodimer interface [polypeptide binding]; other site 471854005961 catalytic residue [active] 471854005962 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 471854005963 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 471854005964 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854005965 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 471854005966 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 471854005967 N-terminal plug; other site 471854005968 ligand-binding site [chemical binding]; other site 471854005969 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854005970 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 471854005971 RibD C-terminal domain; Region: RibD_C; cl17279 471854005972 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854005973 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854005974 SusD family; Region: SusD; pfam07980 471854005975 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854005976 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854005977 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854005978 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854005979 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 471854005980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854005981 heme pocket [chemical binding]; other site 471854005982 putative active site [active] 471854005983 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471854005984 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 471854005985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854005986 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 471854005987 putative active site [active] 471854005988 heme pocket [chemical binding]; other site 471854005989 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 471854005990 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854005991 putative active site [active] 471854005992 heme pocket [chemical binding]; other site 471854005993 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854005994 dimer interface [polypeptide binding]; other site 471854005995 phosphorylation site [posttranslational modification] 471854005996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854005997 ATP binding site [chemical binding]; other site 471854005998 Mg2+ binding site [ion binding]; other site 471854005999 G-X-G motif; other site 471854006000 Response regulator receiver domain; Region: Response_reg; pfam00072 471854006001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854006002 active site 471854006003 phosphorylation site [posttranslational modification] 471854006004 intermolecular recognition site; other site 471854006005 dimerization interface [polypeptide binding]; other site 471854006006 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854006007 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471854006008 FtsX-like permease family; Region: FtsX; pfam02687 471854006009 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854006010 FtsX-like permease family; Region: FtsX; pfam02687 471854006011 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 471854006012 Active site serine [active] 471854006013 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 471854006014 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 471854006015 nudix motif; other site 471854006016 Beta-lactamase; Region: Beta-lactamase; pfam00144 471854006017 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471854006018 hypothetical protein; Provisional; Region: PRK08204 471854006019 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854006020 active site 471854006021 Histidine kinase; Region: His_kinase; pfam06580 471854006022 Histidine kinase; Region: His_kinase; pfam06580 471854006023 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854006024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854006025 active site 471854006026 phosphorylation site [posttranslational modification] 471854006027 intermolecular recognition site; other site 471854006028 dimerization interface [polypeptide binding]; other site 471854006029 LytTr DNA-binding domain; Region: LytTR; smart00850 471854006030 hypothetical protein; Provisional; Region: PRK06753 471854006031 hypothetical protein; Provisional; Region: PRK07236 471854006032 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 471854006033 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cd02795 471854006034 metal binding site [ion binding]; metal-binding site 471854006035 Immunoglobulin domain; Region: Ig; cl11960 471854006036 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cd02795 471854006037 metal binding site [ion binding]; metal-binding site 471854006038 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cd02795 471854006039 metal binding site [ion binding]; metal-binding site 471854006040 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854006041 BNR repeat-like domain; Region: BNR_2; pfam13088 471854006042 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854006043 SusD family; Region: SusD; pfam07980 471854006044 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854006045 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854006046 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854006047 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854006048 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854006049 FecR protein; Region: FecR; pfam04773 471854006050 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854006051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854006052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854006053 DNA binding residues [nucleotide binding] 471854006054 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854006055 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854006056 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854006057 DNA binding residues [nucleotide binding] 471854006058 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854006059 FecR protein; Region: FecR; pfam04773 471854006060 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854006061 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854006062 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854006063 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854006064 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854006065 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854006066 SusD family; Region: SusD; pfam07980 471854006067 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854006068 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854006069 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854006070 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854006071 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854006072 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854006073 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471854006074 Sulfatase; Region: Sulfatase; cl17466 471854006075 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 471854006076 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471854006077 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471854006078 catalytic residues [active] 471854006079 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 471854006080 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 471854006081 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471854006082 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 471854006083 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 471854006084 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854006085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854006086 active site 471854006087 phosphorylation site [posttranslational modification] 471854006088 intermolecular recognition site; other site 471854006089 dimerization interface [polypeptide binding]; other site 471854006090 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854006091 DNA binding residues [nucleotide binding] 471854006092 dimerization interface [polypeptide binding]; other site 471854006093 Right handed beta helix region; Region: Beta_helix; pfam13229 471854006094 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854006095 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 471854006096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471854006097 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471854006098 Coenzyme A binding pocket [chemical binding]; other site 471854006099 DinB family; Region: DinB; cl17821 471854006100 DinB superfamily; Region: DinB_2; pfam12867 471854006101 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471854006102 conserved cys residue [active] 471854006103 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 471854006104 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 471854006105 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854006106 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854006107 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854006108 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854006109 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854006110 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854006111 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854006112 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854006113 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854006114 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854006115 SusD family; Region: SusD; pfam07980 471854006116 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 471854006117 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 471854006118 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 471854006119 active site 471854006120 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854006121 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 471854006122 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 471854006123 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 471854006124 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854006125 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854006126 SusD family; Region: SusD; pfam07980 471854006127 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854006128 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854006129 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854006130 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854006131 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854006132 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854006133 FecR protein; Region: FecR; pfam04773 471854006134 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854006135 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854006136 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854006137 DNA binding residues [nucleotide binding] 471854006138 oxidoreductase; Provisional; Region: PRK06128 471854006139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854006140 NAD(P) binding site [chemical binding]; other site 471854006141 active site 471854006142 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 471854006143 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 471854006144 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 471854006145 catalytic residues [active] 471854006146 catalytic nucleophile [active] 471854006147 Presynaptic Site I dimer interface [polypeptide binding]; other site 471854006148 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 471854006149 Synaptic Flat tetramer interface [polypeptide binding]; other site 471854006150 Synaptic Site I dimer interface [polypeptide binding]; other site 471854006151 DNA binding site [nucleotide binding] 471854006152 HTH domain; Region: HTH_11; cl17392 471854006153 Transposase; Region: HTH_Tnp_1; pfam01527 471854006154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 471854006155 HTH-like domain; Region: HTH_21; pfam13276 471854006156 Integrase core domain; Region: rve; pfam00665 471854006157 Integrase core domain; Region: rve_3; pfam13683 471854006158 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 471854006159 Two component regulator propeller; Region: Reg_prop; pfam07494 471854006160 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 471854006161 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854006162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854006163 dimer interface [polypeptide binding]; other site 471854006164 phosphorylation site [posttranslational modification] 471854006165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854006166 ATP binding site [chemical binding]; other site 471854006167 Mg2+ binding site [ion binding]; other site 471854006168 G-X-G motif; other site 471854006169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854006170 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471854006171 active site 471854006172 phosphorylation site [posttranslational modification] 471854006173 intermolecular recognition site; other site 471854006174 dimerization interface [polypeptide binding]; other site 471854006175 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854006176 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854006177 YceI-like domain; Region: YceI; pfam04264 471854006178 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 471854006179 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 471854006180 nucleophilic elbow; other site 471854006181 catalytic triad; other site 471854006182 Ycf48-like protein; Provisional; Region: PRK13684 471854006183 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 471854006184 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 471854006185 hypothetical protein; Provisional; Region: PRK06184 471854006186 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 471854006187 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471854006188 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854006189 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 471854006190 Thioredoxin; Region: Thioredoxin_5; pfam13743 471854006191 Response regulator receiver domain; Region: Response_reg; pfam00072 471854006192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854006193 active site 471854006194 phosphorylation site [posttranslational modification] 471854006195 intermolecular recognition site; other site 471854006196 dimerization interface [polypeptide binding]; other site 471854006197 Predicted amidohydrolase [General function prediction only]; Region: COG0388 471854006198 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 471854006199 active site 471854006200 catalytic triad [active] 471854006201 dimer interface [polypeptide binding]; other site 471854006202 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471854006203 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 471854006204 putative NAD(P) binding site [chemical binding]; other site 471854006205 Predicted transcriptional regulators [Transcription]; Region: COG1733 471854006206 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471854006207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471854006208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471854006209 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 471854006210 classical (c) SDRs; Region: SDR_c; cd05233 471854006211 NAD(P) binding site [chemical binding]; other site 471854006212 active site 471854006213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854006214 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 471854006215 dimer interface [polypeptide binding]; other site 471854006216 phosphorylation site [posttranslational modification] 471854006217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854006218 ATP binding site [chemical binding]; other site 471854006219 Mg2+ binding site [ion binding]; other site 471854006220 G-X-G motif; other site 471854006221 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854006222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854006223 active site 471854006224 phosphorylation site [posttranslational modification] 471854006225 intermolecular recognition site; other site 471854006226 dimerization interface [polypeptide binding]; other site 471854006227 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854006228 DNA binding residues [nucleotide binding] 471854006229 dimerization interface [polypeptide binding]; other site 471854006230 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854006231 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854006232 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471854006233 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854006234 non-specific DNA binding site [nucleotide binding]; other site 471854006235 salt bridge; other site 471854006236 sequence-specific DNA binding site [nucleotide binding]; other site 471854006237 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 471854006238 Catalytic site [active] 471854006239 Uncharacterized conserved protein [Function unknown]; Region: COG4544 471854006240 DNA Polymerase Y-family; Region: PolY_like; cd03468 471854006241 active site 471854006242 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 471854006243 DNA binding site [nucleotide binding] 471854006244 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 471854006245 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 471854006246 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 471854006247 putative active site [active] 471854006248 putative PHP Thumb interface [polypeptide binding]; other site 471854006249 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 471854006250 generic binding surface II; other site 471854006251 generic binding surface I; other site 471854006252 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 471854006253 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854006254 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 471854006255 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 471854006256 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 471854006257 Histidine kinase; Region: His_kinase; pfam06580 471854006258 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854006259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854006260 active site 471854006261 phosphorylation site [posttranslational modification] 471854006262 intermolecular recognition site; other site 471854006263 dimerization interface [polypeptide binding]; other site 471854006264 LytTr DNA-binding domain; Region: LytTR; smart00850 471854006265 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 471854006266 active site 471854006267 Domain of unknown function (DUF4138); Region: DUF4138; pfam13595 471854006268 Helix-turn-helix domain; Region: HTH_17; cl17695 471854006269 Predicted membrane protein [Function unknown]; Region: COG4270 471854006270 Domain of unknown function (DUF932); Region: DUF932; cl12129 471854006271 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 471854006272 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 471854006273 Int/Topo IB signature motif; other site 471854006274 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854006275 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 471854006276 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 471854006277 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 471854006278 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 471854006279 O-succinylbenzoate synthase; Provisional; Region: PRK02714 471854006280 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 471854006281 active site 471854006282 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 471854006283 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 471854006284 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 471854006285 active site 471854006286 dinuclear metal binding site [ion binding]; other site 471854006287 dimerization interface [polypeptide binding]; other site 471854006288 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 471854006289 serine racemase; Region: PLN02970 471854006290 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471854006291 tetramer interface [polypeptide binding]; other site 471854006292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854006293 catalytic residue [active] 471854006294 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471854006295 ligand binding site [chemical binding]; other site 471854006296 GLPGLI family protein; Region: GLPGLI; TIGR01200 471854006297 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854006298 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854006299 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854006300 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 471854006301 active site 471854006302 metal binding site [ion binding]; metal-binding site 471854006303 homotetramer interface [polypeptide binding]; other site 471854006304 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 471854006305 Peptidase family M28; Region: Peptidase_M28; pfam04389 471854006306 metal binding site [ion binding]; metal-binding site 471854006307 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471854006308 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 471854006309 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471854006310 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471854006311 DNA binding residues [nucleotide binding] 471854006312 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 471854006313 putative hydrophobic ligand binding site [chemical binding]; other site 471854006314 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471854006315 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 471854006316 Response regulator receiver domain; Region: Response_reg; pfam00072 471854006317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854006318 active site 471854006319 phosphorylation site [posttranslational modification] 471854006320 intermolecular recognition site; other site 471854006321 dimerization interface [polypeptide binding]; other site 471854006322 hypothetical protein; Provisional; Region: PRK07877 471854006323 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 471854006324 ATP binding site [chemical binding]; other site 471854006325 substrate interface [chemical binding]; other site 471854006326 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 471854006327 dimer interface [polypeptide binding]; other site 471854006328 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 471854006329 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 471854006330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854006331 dimer interface [polypeptide binding]; other site 471854006332 phosphorylation site [posttranslational modification] 471854006333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854006334 ATP binding site [chemical binding]; other site 471854006335 Mg2+ binding site [ion binding]; other site 471854006336 G-X-G motif; other site 471854006337 Response regulator receiver domain; Region: Response_reg; pfam00072 471854006338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854006339 active site 471854006340 phosphorylation site [posttranslational modification] 471854006341 intermolecular recognition site; other site 471854006342 dimerization interface [polypeptide binding]; other site 471854006343 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854006344 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854006345 dimer interface [polypeptide binding]; other site 471854006346 phosphorylation site [posttranslational modification] 471854006347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854006348 ATP binding site [chemical binding]; other site 471854006349 Mg2+ binding site [ion binding]; other site 471854006350 G-X-G motif; other site 471854006351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854006352 Response regulator receiver domain; Region: Response_reg; pfam00072 471854006353 active site 471854006354 phosphorylation site [posttranslational modification] 471854006355 intermolecular recognition site; other site 471854006356 dimerization interface [polypeptide binding]; other site 471854006357 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 471854006358 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 471854006359 intersubunit interface [polypeptide binding]; other site 471854006360 active site 471854006361 Zn2+ binding site [ion binding]; other site 471854006362 L-arabinose isomerase; Provisional; Region: PRK02929 471854006363 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 471854006364 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 471854006365 trimer interface [polypeptide binding]; other site 471854006366 putative substrate binding site [chemical binding]; other site 471854006367 putative metal binding site [ion binding]; other site 471854006368 ribulokinase; Provisional; Region: PRK04123 471854006369 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 471854006370 N- and C-terminal domain interface [polypeptide binding]; other site 471854006371 active site 471854006372 MgATP binding site [chemical binding]; other site 471854006373 catalytic site [active] 471854006374 metal binding site [ion binding]; metal-binding site 471854006375 carbohydrate binding site [chemical binding]; other site 471854006376 homodimer interface [polypeptide binding]; other site 471854006377 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 471854006378 nudix motif; other site 471854006379 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 471854006380 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854006381 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854006382 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854006383 DNA binding residues [nucleotide binding] 471854006384 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854006385 FecR protein; Region: FecR; pfam04773 471854006386 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854006387 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854006388 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854006389 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854006390 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 471854006391 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854006392 SusD family; Region: SusD; pfam07980 471854006393 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471854006394 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471854006395 active site 471854006396 metal binding site [ion binding]; metal-binding site 471854006397 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 471854006398 putative catalytic site [active] 471854006399 putative metal binding site [ion binding]; other site 471854006400 putative phosphate binding site [ion binding]; other site 471854006401 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 471854006402 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854006403 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854006404 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 471854006405 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854006406 active site 471854006407 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 471854006408 Transglycosylase; Region: Transgly; cl17702 471854006409 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 471854006410 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 471854006411 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 471854006412 active site 471854006413 NTP binding site [chemical binding]; other site 471854006414 metal binding triad [ion binding]; metal-binding site 471854006415 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 471854006416 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471854006417 Zn2+ binding site [ion binding]; other site 471854006418 Mg2+ binding site [ion binding]; other site 471854006419 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 471854006420 apolar tunnel; other site 471854006421 heme binding site [chemical binding]; other site 471854006422 dimerization interface [polypeptide binding]; other site 471854006423 AMP nucleosidase; Provisional; Region: PRK07115 471854006424 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 471854006425 YceI-like domain; Region: YceI; pfam04264 471854006426 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471854006427 MarR family; Region: MarR; pfam01047 471854006428 Maf-like protein; Region: Maf; pfam02545 471854006429 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 471854006430 active site 471854006431 dimer interface [polypeptide binding]; other site 471854006432 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 471854006433 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 471854006434 Ca binding site [ion binding]; other site 471854006435 active site 471854006436 catalytic site [active] 471854006437 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 471854006438 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 471854006439 Predicted membrane protein [Function unknown]; Region: COG2246 471854006440 GtrA-like protein; Region: GtrA; pfam04138 471854006441 acetyl-CoA C-acetyltransferase; Region: PLN02644 471854006442 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471854006443 dimer interface [polypeptide binding]; other site 471854006444 active site 471854006445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854006446 putative substrate translocation pore; other site 471854006447 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 471854006448 putative ligand binding site [chemical binding]; other site 471854006449 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 471854006450 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854006451 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854006452 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854006453 DNA binding residues [nucleotide binding] 471854006454 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854006455 FecR protein; Region: FecR; pfam04773 471854006456 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854006457 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854006458 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854006459 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854006460 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 471854006461 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854006462 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471854006463 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471854006464 catalytic residue [active] 471854006465 dihydroorotase; Provisional; Region: PRK09237 471854006466 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854006467 active site 471854006468 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 471854006469 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471854006470 Cytochrome c; Region: Cytochrom_C; pfam00034 471854006471 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 471854006472 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 471854006473 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471854006474 homotrimer interaction site [polypeptide binding]; other site 471854006475 putative active site [active] 471854006476 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854006477 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854006478 DNA binding residues [nucleotide binding] 471854006479 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 471854006480 Acyltransferase family; Region: Acyl_transf_3; pfam01757 471854006481 Domain of unknown function (DUF955); Region: DUF955; pfam06114 471854006482 fec operon regulator FecR; Reviewed; Region: PRK09774 471854006483 FecR protein; Region: FecR; pfam04773 471854006484 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854006485 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854006486 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854006487 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854006488 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 471854006489 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854006490 dihydroorotase; Provisional; Region: PRK09237 471854006491 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854006492 active site 471854006493 Predicted acyl esterases [General function prediction only]; Region: COG2936 471854006494 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854006495 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 471854006496 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 471854006497 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 471854006498 Sodium Bile acid symporter family; Region: SBF; pfam01758 471854006499 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 471854006500 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854006501 Coenzyme A binding pocket [chemical binding]; other site 471854006502 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 471854006503 thiS-thiF/thiG interaction site; other site 471854006504 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 471854006505 ThiC-associated domain; Region: ThiC-associated; pfam13667 471854006506 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 471854006507 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 471854006508 thiamine phosphate binding site [chemical binding]; other site 471854006509 active site 471854006510 pyrophosphate binding site [ion binding]; other site 471854006511 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 471854006512 thiamine phosphate binding site [chemical binding]; other site 471854006513 active site 471854006514 pyrophosphate binding site [ion binding]; other site 471854006515 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 471854006516 ThiS interaction site; other site 471854006517 putative active site [active] 471854006518 tetramer interface [polypeptide binding]; other site 471854006519 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 471854006520 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471854006521 FeS/SAM binding site; other site 471854006522 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 471854006523 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 471854006524 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 471854006525 ATP binding site [chemical binding]; other site 471854006526 substrate interface [chemical binding]; other site 471854006527 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471854006528 active site residue [active] 471854006529 Predicted amidohydrolase [General function prediction only]; Region: COG0388 471854006530 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 471854006531 putative active site [active] 471854006532 catalytic triad [active] 471854006533 putative dimer interface [polypeptide binding]; other site 471854006534 AAA domain; Region: AAA_14; pfam13173 471854006535 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 471854006536 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 471854006537 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 471854006538 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 471854006539 oligomeric interface; other site 471854006540 putative active site [active] 471854006541 homodimer interface [polypeptide binding]; other site 471854006542 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854006543 non-specific DNA binding site [nucleotide binding]; other site 471854006544 salt bridge; other site 471854006545 sequence-specific DNA binding site [nucleotide binding]; other site 471854006546 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 471854006547 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 471854006548 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 471854006549 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471854006550 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 471854006551 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471854006552 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 471854006553 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 471854006554 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471854006555 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 471854006556 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471854006557 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854006558 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 471854006559 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 471854006560 prenyltransferase; Reviewed; Region: ubiA; PRK12872 471854006561 UbiA prenyltransferase family; Region: UbiA; pfam01040 471854006562 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 471854006563 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 471854006564 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 471854006565 active site 471854006566 substrate binding site [chemical binding]; other site 471854006567 cosubstrate binding site; other site 471854006568 catalytic site [active] 471854006569 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 471854006570 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 471854006571 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 471854006572 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471854006573 ATP binding site [chemical binding]; other site 471854006574 Mg++ binding site [ion binding]; other site 471854006575 motif III; other site 471854006576 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854006577 nucleotide binding region [chemical binding]; other site 471854006578 ATP-binding site [chemical binding]; other site 471854006579 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471854006580 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471854006581 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854006582 Walker A/P-loop; other site 471854006583 ATP binding site [chemical binding]; other site 471854006584 Q-loop/lid; other site 471854006585 ABC transporter signature motif; other site 471854006586 Walker B; other site 471854006587 D-loop; other site 471854006588 H-loop/switch region; other site 471854006589 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 471854006590 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 471854006591 tRNA; other site 471854006592 putative tRNA binding site [nucleotide binding]; other site 471854006593 putative NADP binding site [chemical binding]; other site 471854006594 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 471854006595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854006596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854006597 ATP binding site [chemical binding]; other site 471854006598 Mg2+ binding site [ion binding]; other site 471854006599 G-X-G motif; other site 471854006600 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 471854006601 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 471854006602 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 471854006603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471854006604 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471854006605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 471854006606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 471854006607 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 471854006608 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854006609 putative metal binding site [ion binding]; other site 471854006610 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 471854006611 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 471854006612 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 471854006613 ligand binding site [chemical binding]; other site 471854006614 SurA N-terminal domain; Region: SurA_N; pfam09312 471854006615 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 471854006616 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 471854006617 MoxR-like ATPases [General function prediction only]; Region: COG0714 471854006618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854006619 Walker A motif; other site 471854006620 ATP binding site [chemical binding]; other site 471854006621 Walker B motif; other site 471854006622 arginine finger; other site 471854006623 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 471854006624 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 471854006625 dimer interface [polypeptide binding]; other site 471854006626 NADP binding site [chemical binding]; other site 471854006627 catalytic residues [active] 471854006628 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 471854006629 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 471854006630 dimerization interface 3.5A [polypeptide binding]; other site 471854006631 active site 471854006632 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 471854006633 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471854006634 active site 471854006635 HIGH motif; other site 471854006636 nucleotide binding site [chemical binding]; other site 471854006637 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 471854006638 KMSKS motif; other site 471854006639 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 471854006640 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 471854006641 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 471854006642 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854006643 non-specific DNA binding site [nucleotide binding]; other site 471854006644 salt bridge; other site 471854006645 sequence-specific DNA binding site [nucleotide binding]; other site 471854006646 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 471854006647 Ferritin-like domain; Region: Ferritin; pfam00210 471854006648 ferroxidase diiron center [ion binding]; other site 471854006649 HPP family; Region: HPP; pfam04982 471854006650 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 471854006651 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 471854006652 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 471854006653 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 471854006654 EamA-like transporter family; Region: EamA; pfam00892 471854006655 EamA-like transporter family; Region: EamA; pfam00892 471854006656 PAS fold; Region: PAS_4; pfam08448 471854006657 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 471854006658 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 471854006659 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854006660 putative active site [active] 471854006661 heme pocket [chemical binding]; other site 471854006662 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 471854006663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854006664 putative active site [active] 471854006665 heme pocket [chemical binding]; other site 471854006666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854006667 dimer interface [polypeptide binding]; other site 471854006668 phosphorylation site [posttranslational modification] 471854006669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854006670 ATP binding site [chemical binding]; other site 471854006671 Mg2+ binding site [ion binding]; other site 471854006672 G-X-G motif; other site 471854006673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854006674 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471854006675 active site 471854006676 phosphorylation site [posttranslational modification] 471854006677 intermolecular recognition site; other site 471854006678 dimerization interface [polypeptide binding]; other site 471854006679 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854006680 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 471854006681 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854006682 multidrug efflux protein; Reviewed; Region: PRK01766 471854006683 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 471854006684 cation binding site [ion binding]; other site 471854006685 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 471854006686 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 471854006687 tetrameric interface [polypeptide binding]; other site 471854006688 activator binding site; other site 471854006689 NADP binding site [chemical binding]; other site 471854006690 substrate binding site [chemical binding]; other site 471854006691 catalytic residues [active] 471854006692 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471854006693 active site residue [active] 471854006694 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471854006695 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471854006696 catalytic residues [active] 471854006697 Sulfatase; Region: Sulfatase; cl17466 471854006698 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471854006699 HEAT repeats; Region: HEAT_2; pfam13646 471854006700 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471854006701 Sulfatase; Region: Sulfatase; pfam00884 471854006702 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 471854006703 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854006704 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854006705 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854006706 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854006707 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854006708 Response regulator receiver domain; Region: Response_reg; pfam00072 471854006709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854006710 active site 471854006711 phosphorylation site [posttranslational modification] 471854006712 intermolecular recognition site; other site 471854006713 dimerization interface [polypeptide binding]; other site 471854006714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854006715 PAS fold; Region: PAS_3; pfam08447 471854006716 putative active site [active] 471854006717 heme pocket [chemical binding]; other site 471854006718 PAS domain; Region: PAS_8; pfam13188 471854006719 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 471854006720 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854006721 putative active site [active] 471854006722 heme pocket [chemical binding]; other site 471854006723 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854006724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854006725 dimer interface [polypeptide binding]; other site 471854006726 phosphorylation site [posttranslational modification] 471854006727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854006728 ATP binding site [chemical binding]; other site 471854006729 Mg2+ binding site [ion binding]; other site 471854006730 G-X-G motif; other site 471854006731 Response regulator receiver domain; Region: Response_reg; pfam00072 471854006732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854006733 active site 471854006734 phosphorylation site [posttranslational modification] 471854006735 intermolecular recognition site; other site 471854006736 dimerization interface [polypeptide binding]; other site 471854006737 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854006738 Family description; Region: VCBS; pfam13517 471854006739 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854006740 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854006741 Family description; Region: VCBS; pfam13517 471854006742 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854006743 Family description; Region: VCBS; pfam13517 471854006744 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854006745 Family description; Region: VCBS; pfam13517 471854006746 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854006747 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854006748 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854006749 Family description; Region: VCBS; pfam13517 471854006750 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854006751 Family description; Region: VCBS; pfam13517 471854006752 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854006753 Family description; Region: VCBS; pfam13517 471854006754 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854006755 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854006756 Family description; Region: VCBS; pfam13517 471854006757 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854006758 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854006759 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854006760 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 471854006761 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 471854006762 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 471854006763 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854006764 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854006765 SusD family; Region: SusD; pfam07980 471854006766 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854006767 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854006768 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854006769 Response regulator receiver domain; Region: Response_reg; pfam00072 471854006770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854006771 active site 471854006772 phosphorylation site [posttranslational modification] 471854006773 intermolecular recognition site; other site 471854006774 dimerization interface [polypeptide binding]; other site 471854006775 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854006776 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 471854006777 putative active site [active] 471854006778 heme pocket [chemical binding]; other site 471854006779 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854006780 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 471854006781 putative active site [active] 471854006782 heme pocket [chemical binding]; other site 471854006783 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854006784 putative active site [active] 471854006785 heme pocket [chemical binding]; other site 471854006786 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 471854006787 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471854006788 active site 471854006789 metal binding site [ion binding]; metal-binding site 471854006790 Surface antigen; Region: Bac_surface_Ag; pfam01103 471854006791 SdiA-regulated; Region: SdiA-regulated; cd09971 471854006792 putative active site [active] 471854006793 polyphosphate kinase; Provisional; Region: PRK05443 471854006794 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 471854006795 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 471854006796 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 471854006797 domain interface [polypeptide binding]; other site 471854006798 active site 471854006799 catalytic site [active] 471854006800 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 471854006801 domain interface [polypeptide binding]; other site 471854006802 active site 471854006803 catalytic site [active] 471854006804 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471854006805 Zn2+ binding site [ion binding]; other site 471854006806 Mg2+ binding site [ion binding]; other site 471854006807 GAF domain; Region: GAF; cl17456 471854006808 GAF domain; Region: GAF_2; pfam13185 471854006809 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471854006810 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471854006811 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471854006812 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 471854006813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854006814 S-adenosylmethionine binding site [chemical binding]; other site 471854006815 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 471854006816 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 471854006817 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471854006818 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 471854006819 substrate binding site [chemical binding]; other site 471854006820 ATP binding site [chemical binding]; other site 471854006821 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471854006822 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471854006823 motif II; other site 471854006824 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 471854006825 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 471854006826 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471854006827 active site 471854006828 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854006829 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471854006830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854006831 NAD(P) binding site [chemical binding]; other site 471854006832 active site 471854006833 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 471854006834 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 471854006835 substrate-cofactor binding pocket; other site 471854006836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854006837 catalytic residue [active] 471854006838 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 471854006839 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854006840 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854006841 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854006842 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 471854006843 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471854006844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471854006845 Predicted membrane protein [Function unknown]; Region: COG2323 471854006846 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 471854006847 ApbE family; Region: ApbE; pfam02424 471854006848 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 471854006849 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471854006850 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854006851 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471854006852 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 471854006853 ligand binding site [chemical binding]; other site 471854006854 flexible hinge region; other site 471854006855 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471854006856 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854006857 Coenzyme A binding pocket [chemical binding]; other site 471854006858 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 471854006859 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 471854006860 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 471854006861 active site 471854006862 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 471854006863 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 471854006864 NADP binding site [chemical binding]; other site 471854006865 homopentamer interface [polypeptide binding]; other site 471854006866 substrate binding site [chemical binding]; other site 471854006867 active site 471854006868 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 471854006869 putative ABC transporter; Region: ycf24; CHL00085 471854006870 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 471854006871 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 471854006872 TrkA-C domain; Region: TrkA_C; pfam02080 471854006873 TrkA-C domain; Region: TrkA_C; pfam02080 471854006874 D-cysteine desulfhydrase; Validated; Region: PRK03910 471854006875 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 471854006876 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471854006877 catalytic residue [active] 471854006878 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 471854006879 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471854006880 RNA binding surface [nucleotide binding]; other site 471854006881 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 471854006882 active site 471854006883 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471854006884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854006885 Coenzyme A binding pocket [chemical binding]; other site 471854006886 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 471854006887 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 471854006888 RimM N-terminal domain; Region: RimM; pfam01782 471854006889 PRC-barrel domain; Region: PRC; pfam05239 471854006890 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 471854006891 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 471854006892 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 471854006893 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471854006894 ligand binding site [chemical binding]; other site 471854006895 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 471854006896 Smr domain; Region: Smr; pfam01713 471854006897 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471854006898 metal ion-dependent adhesion site (MIDAS); other site 471854006899 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 471854006900 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 471854006901 NAD(P) binding site [chemical binding]; other site 471854006902 homotetramer interface [polypeptide binding]; other site 471854006903 homodimer interface [polypeptide binding]; other site 471854006904 active site 471854006905 Predicted membrane protein [Function unknown]; Region: COG4682 471854006906 yiaA/B two helix domain; Region: YiaAB; pfam05360 471854006907 yiaA/B two helix domain; Region: YiaAB; pfam05360 471854006908 short chain dehydrogenase; Provisional; Region: PRK07326 471854006909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854006910 NAD(P) binding site [chemical binding]; other site 471854006911 active site 471854006912 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854006913 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 471854006914 Walker A/P-loop; other site 471854006915 ATP binding site [chemical binding]; other site 471854006916 Q-loop/lid; other site 471854006917 ABC transporter signature motif; other site 471854006918 Walker B; other site 471854006919 D-loop; other site 471854006920 H-loop/switch region; other site 471854006921 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 471854006922 active site 471854006923 dimer interface [polypeptide binding]; other site 471854006924 catalytic nucleophile [active] 471854006925 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 471854006926 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 471854006927 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 471854006928 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 471854006929 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 471854006930 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 471854006931 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471854006932 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471854006933 Metal-binding active site; metal-binding site 471854006934 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 471854006935 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 471854006936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 471854006937 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471854006938 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471854006939 DNA binding site [nucleotide binding] 471854006940 domain linker motif; other site 471854006941 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471854006942 dimerization interface [polypeptide binding]; other site 471854006943 ligand binding site [chemical binding]; other site 471854006944 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854006945 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854006946 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854006947 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854006948 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854006949 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854006950 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 471854006951 putative metal binding site [ion binding]; other site 471854006952 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 471854006953 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471854006954 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 471854006955 ApbE family; Region: ApbE; pfam02424 471854006956 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 471854006957 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 471854006958 Na binding site [ion binding]; other site 471854006959 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 471854006960 beta-D-glucuronidase; Provisional; Region: PRK10150 471854006961 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471854006962 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 471854006963 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471854006964 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471854006965 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 471854006966 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 471854006967 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471854006968 homodimer interface [polypeptide binding]; other site 471854006969 substrate-cofactor binding pocket; other site 471854006970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854006971 catalytic residue [active] 471854006972 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 471854006973 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 471854006974 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 471854006975 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 471854006976 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 471854006977 Active Sites [active] 471854006978 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 471854006979 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 471854006980 Active Sites [active] 471854006981 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 471854006982 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 471854006983 CysD dimerization site [polypeptide binding]; other site 471854006984 G1 box; other site 471854006985 putative GEF interaction site [polypeptide binding]; other site 471854006986 GTP/Mg2+ binding site [chemical binding]; other site 471854006987 Switch I region; other site 471854006988 G2 box; other site 471854006989 G3 box; other site 471854006990 Switch II region; other site 471854006991 G4 box; other site 471854006992 G5 box; other site 471854006993 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 471854006994 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 471854006995 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 471854006996 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471854006997 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471854006998 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 471854006999 active site 471854007000 SAM binding site [chemical binding]; other site 471854007001 homodimer interface [polypeptide binding]; other site 471854007002 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 471854007003 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 471854007004 putative acyl-acceptor binding pocket; other site 471854007005 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 471854007006 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 471854007007 putative active site [active] 471854007008 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 471854007009 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 471854007010 putative active site; other site 471854007011 catalytic triad [active] 471854007012 putative dimer interface [polypeptide binding]; other site 471854007013 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854007014 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854007015 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854007016 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854007017 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 471854007018 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854007019 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 471854007020 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471854007021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854007022 homodimer interface [polypeptide binding]; other site 471854007023 catalytic residue [active] 471854007024 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 471854007025 thioester formation/cholesterol transfer; other site 471854007026 protein-splicing catalytic site; other site 471854007027 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 471854007028 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 471854007029 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 471854007030 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 471854007031 active site 471854007032 Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: LeuS; COG0495 471854007033 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471854007034 active site 471854007035 HIGH motif; other site 471854007036 nucleotide binding site [chemical binding]; other site 471854007037 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471854007038 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471854007039 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471854007040 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471854007041 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471854007042 active site 471854007043 KMSKS motif; other site 471854007044 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 471854007045 tRNA binding surface [nucleotide binding]; other site 471854007046 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 471854007047 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 471854007048 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471854007049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854007050 non-specific DNA binding site [nucleotide binding]; other site 471854007051 salt bridge; other site 471854007052 sequence-specific DNA binding site [nucleotide binding]; other site 471854007053 Domain of unknown function (DUF955); Region: DUF955; pfam06114 471854007054 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 471854007055 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 471854007056 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471854007057 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471854007058 active site 471854007059 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 471854007060 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854007061 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 471854007062 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471854007063 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 471854007064 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 471854007065 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 471854007066 putative active site [active] 471854007067 putative CoA binding site [chemical binding]; other site 471854007068 nudix motif; other site 471854007069 metal binding site [ion binding]; metal-binding site 471854007070 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 471854007071 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 471854007072 CAP-like domain; other site 471854007073 active site 471854007074 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 471854007075 putative active site [active] 471854007076 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854007077 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 471854007078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854007079 Walker A/P-loop; other site 471854007080 ATP binding site [chemical binding]; other site 471854007081 Q-loop/lid; other site 471854007082 ABC transporter signature motif; other site 471854007083 Walker B; other site 471854007084 D-loop; other site 471854007085 H-loop/switch region; other site 471854007086 TOBE domain; Region: TOBE_2; pfam08402 471854007087 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 471854007088 putative FMN binding site [chemical binding]; other site 471854007089 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 471854007090 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 471854007091 FAD binding site [chemical binding]; other site 471854007092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471854007093 hypothetical protein; Provisional; Region: PRK12378 471854007094 Lamin Tail Domain; Region: LTD; pfam00932 471854007095 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 471854007096 CotH protein; Region: CotH; pfam08757 471854007097 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854007098 Domain of unknown function (DUF303); Region: DUF303; pfam03629 471854007099 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854007100 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 471854007101 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471854007102 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 471854007103 A new structural DNA glycosylase; Region: AlkD_like; cd06561 471854007104 active site 471854007105 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 471854007106 short chain dehydrogenase; Provisional; Region: PRK07677 471854007107 NAD(P) binding site [chemical binding]; other site 471854007108 substrate binding site [chemical binding]; other site 471854007109 homotetramer interface [polypeptide binding]; other site 471854007110 active site 471854007111 homodimer interface [polypeptide binding]; other site 471854007112 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471854007113 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 471854007114 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471854007115 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 471854007116 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 471854007117 Ligand Binding Site [chemical binding]; other site 471854007118 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 471854007119 GTP binding site; other site 471854007120 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 471854007121 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 471854007122 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 471854007123 putative molybdopterin cofactor binding site [chemical binding]; other site 471854007124 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 471854007125 putative molybdopterin cofactor binding site; other site 471854007126 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471854007127 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471854007128 active site 471854007129 catalytic site [active] 471854007130 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 471854007131 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 471854007132 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 471854007133 Peptidase family M28; Region: Peptidase_M28; pfam04389 471854007134 metal binding site [ion binding]; metal-binding site 471854007135 Trehalase; Region: Trehalase; cl17346 471854007136 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 471854007137 EamA-like transporter family; Region: EamA; pfam00892 471854007138 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471854007139 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 471854007140 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854007141 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 471854007142 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471854007143 ligand binding site [chemical binding]; other site 471854007144 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 471854007145 putative active site [active] 471854007146 catalytic residue [active] 471854007147 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 471854007148 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471854007149 active site 471854007150 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 471854007151 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 471854007152 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471854007153 active site 471854007154 HIGH motif; other site 471854007155 nucleotide binding site [chemical binding]; other site 471854007156 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 471854007157 KMSK motif region; other site 471854007158 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471854007159 tRNA binding surface [nucleotide binding]; other site 471854007160 anticodon binding site; other site 471854007161 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 471854007162 catalytic residues [active] 471854007163 dimer interface [polypeptide binding]; other site 471854007164 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 471854007165 UbiA prenyltransferase family; Region: UbiA; pfam01040 471854007166 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 471854007167 active site 471854007168 catalytic triad [active] 471854007169 oxyanion hole [active] 471854007170 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471854007171 active site 471854007172 catalytic triad [active] 471854007173 oxyanion hole [active] 471854007174 PKD domain; Region: PKD; pfam00801 471854007175 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 471854007176 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 471854007177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854007178 Walker A/P-loop; other site 471854007179 ATP binding site [chemical binding]; other site 471854007180 ABC transporter; Region: ABC_tran; pfam00005 471854007181 Q-loop/lid; other site 471854007182 ABC transporter signature motif; other site 471854007183 Walker B; other site 471854007184 D-loop; other site 471854007185 H-loop/switch region; other site 471854007186 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471854007187 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471854007188 Transporter associated domain; Region: CorC_HlyC; smart01091 471854007189 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 471854007190 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 471854007191 active site 471854007192 intersubunit interface [polypeptide binding]; other site 471854007193 zinc binding site [ion binding]; other site 471854007194 Na+ binding site [ion binding]; other site 471854007195 Immunoglobulin domain; Region: Ig; cl11960 471854007196 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 471854007197 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 471854007198 catalytic motif [active] 471854007199 Catalytic residue [active] 471854007200 Predicted transcriptional regulators [Transcription]; Region: COG1733 471854007201 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471854007202 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 471854007203 dimer interface [polypeptide binding]; other site 471854007204 FMN binding site [chemical binding]; other site 471854007205 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 471854007206 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 471854007207 catalytic residues [active] 471854007208 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854007209 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 471854007210 Zn binding site [ion binding]; other site 471854007211 GMP synthase; Reviewed; Region: guaA; PRK00074 471854007212 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 471854007213 AMP/PPi binding site [chemical binding]; other site 471854007214 candidate oxyanion hole; other site 471854007215 catalytic triad [active] 471854007216 potential glutamine specificity residues [chemical binding]; other site 471854007217 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 471854007218 ATP Binding subdomain [chemical binding]; other site 471854007219 Ligand Binding sites [chemical binding]; other site 471854007220 Dimerization subdomain; other site 471854007221 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854007222 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854007223 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854007224 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854007225 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854007226 Phosphoglycerate kinase; Region: PGK; pfam00162 471854007227 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 471854007228 substrate binding site [chemical binding]; other site 471854007229 hinge regions; other site 471854007230 ADP binding site [chemical binding]; other site 471854007231 catalytic site [active] 471854007232 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 471854007233 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471854007234 putative catalytic site [active] 471854007235 putative metal binding site [ion binding]; other site 471854007236 putative phosphate binding site [ion binding]; other site 471854007237 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471854007238 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471854007239 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471854007240 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471854007241 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471854007242 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471854007243 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854007244 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 471854007245 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 471854007246 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 471854007247 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 471854007248 Chromate transporter; Region: Chromate_transp; pfam02417 471854007249 Chromate transporter; Region: Chromate_transp; pfam02417 471854007250 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471854007251 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471854007252 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 471854007253 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471854007254 Beta-lactamase; Region: Beta-lactamase; cl17358 471854007255 Protein of unknown function (DUF721); Region: DUF721; pfam05258 471854007256 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 471854007257 dimer interface [polypeptide binding]; other site 471854007258 catalytic triad [active] 471854007259 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 471854007260 short chain dehydrogenase; Provisional; Region: PRK06181 471854007261 NADP binding site [chemical binding]; other site 471854007262 homodimer interface [polypeptide binding]; other site 471854007263 substrate binding site [chemical binding]; other site 471854007264 active site 471854007265 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 471854007266 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471854007267 metal binding site [ion binding]; metal-binding site 471854007268 putative dimer interface [polypeptide binding]; other site 471854007269 Lipid-binding putative hydrolase; Region: Lipid_bd; pfam12888 471854007270 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 471854007271 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854007272 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854007273 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854007274 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854007275 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854007276 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854007277 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854007278 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854007279 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854007280 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 471854007281 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854007282 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854007283 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854007284 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854007285 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854007286 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 471854007287 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854007288 aminotransferase AlaT; Validated; Region: PRK09265 471854007289 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471854007290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854007291 homodimer interface [polypeptide binding]; other site 471854007292 catalytic residue [active] 471854007293 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 471854007294 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471854007295 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 471854007296 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471854007297 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 471854007298 Surface antigen; Region: Bac_surface_Ag; pfam01103 471854007299 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 471854007300 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471854007301 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471854007302 FeS/SAM binding site; other site 471854007303 TRAM domain; Region: TRAM; pfam01938 471854007304 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 471854007305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854007306 Walker A motif; other site 471854007307 ATP binding site [chemical binding]; other site 471854007308 Walker B motif; other site 471854007309 arginine finger; other site 471854007310 Lipopolysaccharide-assembly; Region: LptE; pfam04390 471854007311 Preprotein translocase SecG subunit; Region: SecG; pfam03840 471854007312 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 471854007313 oligomerisation interface [polypeptide binding]; other site 471854007314 mobile loop; other site 471854007315 roof hairpin; other site 471854007316 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 471854007317 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 471854007318 ring oligomerisation interface [polypeptide binding]; other site 471854007319 ATP/Mg binding site [chemical binding]; other site 471854007320 stacking interactions; other site 471854007321 hinge regions; other site 471854007322 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471854007323 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471854007324 Walker A/P-loop; other site 471854007325 ATP binding site [chemical binding]; other site 471854007326 Q-loop/lid; other site 471854007327 ABC transporter signature motif; other site 471854007328 Walker B; other site 471854007329 D-loop; other site 471854007330 H-loop/switch region; other site 471854007331 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 471854007332 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 471854007333 CoA-ligase; Region: Ligase_CoA; pfam00549 471854007334 HEPN domain; Region: HEPN; pfam05168 471854007335 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471854007336 active site 471854007337 NTP binding site [chemical binding]; other site 471854007338 metal binding triad [ion binding]; metal-binding site 471854007339 antibiotic binding site [chemical binding]; other site 471854007340 fructuronate transporter; Provisional; Region: PRK10034; cl15264 471854007341 GntP family permease; Region: GntP_permease; pfam02447 471854007342 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 471854007343 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471854007344 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 471854007345 Uncharacterized conserved protein [Function unknown]; Region: COG4850 471854007346 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 471854007347 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471854007348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854007349 active site 471854007350 phosphorylation site [posttranslational modification] 471854007351 intermolecular recognition site; other site 471854007352 dimerization interface [polypeptide binding]; other site 471854007353 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471854007354 DNA binding site [nucleotide binding] 471854007355 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 471854007356 HAMP domain; Region: HAMP; pfam00672 471854007357 dimerization interface [polypeptide binding]; other site 471854007358 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854007359 dimer interface [polypeptide binding]; other site 471854007360 phosphorylation site [posttranslational modification] 471854007361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854007362 ATP binding site [chemical binding]; other site 471854007363 Mg2+ binding site [ion binding]; other site 471854007364 G-X-G motif; other site 471854007365 Outer membrane efflux protein; Region: OEP; pfam02321 471854007366 Outer membrane efflux protein; Region: OEP; pfam02321 471854007367 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854007368 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854007369 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854007370 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 471854007371 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471854007372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854007373 active site 471854007374 phosphorylation site [posttranslational modification] 471854007375 intermolecular recognition site; other site 471854007376 dimerization interface [polypeptide binding]; other site 471854007377 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 471854007378 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854007379 putative active site [active] 471854007380 heme pocket [chemical binding]; other site 471854007381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854007382 dimer interface [polypeptide binding]; other site 471854007383 phosphorylation site [posttranslational modification] 471854007384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854007385 ATP binding site [chemical binding]; other site 471854007386 Mg2+ binding site [ion binding]; other site 471854007387 G-X-G motif; other site 471854007388 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 471854007389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854007390 active site 471854007391 phosphorylation site [posttranslational modification] 471854007392 intermolecular recognition site; other site 471854007393 dimerization interface [polypeptide binding]; other site 471854007394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854007395 Walker A motif; other site 471854007396 ATP binding site [chemical binding]; other site 471854007397 Walker B motif; other site 471854007398 arginine finger; other site 471854007399 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 471854007400 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 471854007401 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 471854007402 Response regulator receiver domain; Region: Response_reg; pfam00072 471854007403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854007404 active site 471854007405 phosphorylation site [posttranslational modification] 471854007406 intermolecular recognition site; other site 471854007407 dimerization interface [polypeptide binding]; other site 471854007408 TPR repeat; Region: TPR_11; pfam13414 471854007409 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854007410 binding surface 471854007411 TPR motif; other site 471854007412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854007413 binding surface 471854007414 TPR motif; other site 471854007415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854007416 binding surface 471854007417 TPR motif; other site 471854007418 TPR repeat; Region: TPR_11; pfam13414 471854007419 TPR repeat; Region: TPR_11; pfam13414 471854007420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854007421 TPR motif; other site 471854007422 binding surface 471854007423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854007424 binding surface 471854007425 TPR motif; other site 471854007426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854007427 TPR motif; other site 471854007428 binding surface 471854007429 maltose phosphorylase; Provisional; Region: PRK13807 471854007430 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 471854007431 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 471854007432 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 471854007433 beta-phosphoglucomutase; Region: bPGM; TIGR01990 471854007434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471854007435 active site 471854007436 motif I; other site 471854007437 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 471854007438 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349 471854007439 active site 471854007440 catalytic site [active] 471854007441 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 471854007442 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 471854007443 Mechanosensitive ion channel; Region: MS_channel; pfam00924 471854007444 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854007445 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471854007446 dimerization interface [polypeptide binding]; other site 471854007447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854007448 dimer interface [polypeptide binding]; other site 471854007449 phosphorylation site [posttranslational modification] 471854007450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854007451 ATP binding site [chemical binding]; other site 471854007452 Mg2+ binding site [ion binding]; other site 471854007453 G-X-G motif; other site 471854007454 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471854007455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854007456 active site 471854007457 phosphorylation site [posttranslational modification] 471854007458 intermolecular recognition site; other site 471854007459 dimerization interface [polypeptide binding]; other site 471854007460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471854007461 DNA binding site [nucleotide binding] 471854007462 DinB superfamily; Region: DinB_2; pfam12867 471854007463 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 471854007464 Chorismate mutase type II; Region: CM_2; cl00693 471854007465 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 471854007466 Prephenate dehydratase; Region: PDT; pfam00800 471854007467 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 471854007468 putative L-Phe binding site [chemical binding]; other site 471854007469 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 471854007470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854007471 ATP binding site [chemical binding]; other site 471854007472 Mg2+ binding site [ion binding]; other site 471854007473 G-X-G motif; other site 471854007474 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 471854007475 ATP binding site [chemical binding]; other site 471854007476 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 471854007477 active site 471854007478 putative metal-binding site [ion binding]; other site 471854007479 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471854007480 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 471854007481 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 471854007482 SLBB domain; Region: SLBB; pfam10531 471854007483 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 471854007484 SLBB domain; Region: SLBB; pfam10531 471854007485 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 471854007486 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 471854007487 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 471854007488 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 471854007489 Walker A/P-loop; other site 471854007490 ATP binding site [chemical binding]; other site 471854007491 Q-loop/lid; other site 471854007492 ABC transporter signature motif; other site 471854007493 Walker B; other site 471854007494 D-loop; other site 471854007495 H-loop/switch region; other site 471854007496 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 471854007497 putative carbohydrate binding site [chemical binding]; other site 471854007498 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 471854007499 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471854007500 inhibitor-cofactor binding pocket; inhibition site 471854007501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854007502 catalytic residue [active] 471854007503 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 471854007504 WbqC-like protein family; Region: WbqC; pfam08889 471854007505 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 471854007506 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 471854007507 putative trimer interface [polypeptide binding]; other site 471854007508 putative CoA binding site [chemical binding]; other site 471854007509 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471854007510 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854007511 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471854007512 active site 471854007513 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471854007514 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 471854007515 metal-binding site 471854007516 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471854007517 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471854007518 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471854007519 catalytic residues [active] 471854007520 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 471854007521 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 471854007522 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854007523 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 471854007524 active site 471854007525 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 471854007526 B12 binding site [chemical binding]; other site 471854007527 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 471854007528 Fic/DOC family; Region: Fic; pfam02661 471854007529 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 471854007530 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471854007531 active site 471854007532 metal binding site [ion binding]; metal-binding site 471854007533 Predicted acyl esterases [General function prediction only]; Region: COG2936 471854007534 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 471854007535 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471854007536 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 471854007537 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 471854007538 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854007539 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 471854007540 putative active site [active] 471854007541 Zn binding site [ion binding]; other site 471854007542 Dehydroquinase class II; Region: DHquinase_II; pfam01220 471854007543 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 471854007544 trimer interface [polypeptide binding]; other site 471854007545 active site 471854007546 dimer interface [polypeptide binding]; other site 471854007547 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 471854007548 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 471854007549 active site 471854007550 Int/Topo IB signature motif; other site 471854007551 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471854007552 catalytic core [active] 471854007553 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 471854007554 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 471854007555 oligomer interface [polypeptide binding]; other site 471854007556 tandem repeat interface [polypeptide binding]; other site 471854007557 active site residues [active] 471854007558 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 471854007559 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 471854007560 oligomer interface [polypeptide binding]; other site 471854007561 tandem repeat interface [polypeptide binding]; other site 471854007562 active site residues [active] 471854007563 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 471854007564 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 471854007565 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 471854007566 Nucleoside recognition; Region: Gate; pfam07670 471854007567 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 471854007568 SnoaL-like domain; Region: SnoaL_3; pfam13474 471854007569 SnoaL-like domain; Region: SnoaL_4; cl17707 471854007570 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 471854007571 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 471854007572 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 471854007573 substrate binding pocket [chemical binding]; other site 471854007574 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 471854007575 B12 binding site [chemical binding]; other site 471854007576 cobalt ligand [ion binding]; other site 471854007577 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 471854007578 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471854007579 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471854007580 dimerization interface [polypeptide binding]; other site 471854007581 putative DNA binding site [nucleotide binding]; other site 471854007582 putative Zn2+ binding site [ion binding]; other site 471854007583 AsnC family; Region: AsnC_trans_reg; pfam01037 471854007584 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 471854007585 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854007586 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854007587 DNA binding residues [nucleotide binding] 471854007588 exopolyphosphatase; Region: exo_poly_only; TIGR03706 471854007589 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 471854007590 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 471854007591 active site 471854007592 oxyanion hole [active] 471854007593 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 471854007594 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 471854007595 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 471854007596 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 471854007597 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 471854007598 THF binding site; other site 471854007599 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 471854007600 substrate binding site [chemical binding]; other site 471854007601 THF binding site; other site 471854007602 zinc-binding site [ion binding]; other site 471854007603 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 471854007604 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 471854007605 active site 471854007606 trimer interface [polypeptide binding]; other site 471854007607 allosteric site; other site 471854007608 active site lid [active] 471854007609 hexamer (dimer of trimers) interface [polypeptide binding]; other site 471854007610 fumarate hydratase; Reviewed; Region: fumC; PRK00485 471854007611 Class II fumarases; Region: Fumarase_classII; cd01362 471854007612 active site 471854007613 tetramer interface [polypeptide binding]; other site 471854007614 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 471854007615 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 471854007616 NAD binding site [chemical binding]; other site 471854007617 ligand binding site [chemical binding]; other site 471854007618 catalytic site [active] 471854007619 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 471854007620 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 471854007621 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 471854007622 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 471854007623 active site 471854007624 catalytic residues [active] 471854007625 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 471854007626 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 471854007627 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 471854007628 phosphate binding site [ion binding]; other site 471854007629 PspC domain; Region: PspC; pfam04024 471854007630 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 471854007631 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 471854007632 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854007633 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854007634 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854007635 DNA binding residues [nucleotide binding] 471854007636 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854007637 FecR protein; Region: FecR; pfam04773 471854007638 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854007639 NAD+ synthase (glutamine-hydrolysing); Region: PLN02339 471854007640 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 471854007641 multimer interface [polypeptide binding]; other site 471854007642 active site 471854007643 catalytic triad [active] 471854007644 protein interface 1 [polypeptide binding]; other site 471854007645 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 471854007646 Ligand Binding Site [chemical binding]; other site 471854007647 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 471854007648 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854007649 FtsX-like permease family; Region: FtsX; pfam02687 471854007650 methionine aminotransferase; Validated; Region: PRK09082 471854007651 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471854007652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854007653 homodimer interface [polypeptide binding]; other site 471854007654 catalytic residue [active] 471854007655 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471854007656 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 471854007657 nudix motif; other site 471854007658 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471854007659 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471854007660 DNA binding site [nucleotide binding] 471854007661 domain linker motif; other site 471854007662 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471854007663 ligand binding site [chemical binding]; other site 471854007664 dimerization interface [polypeptide binding]; other site 471854007665 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 471854007666 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 471854007667 NADP binding site [chemical binding]; other site 471854007668 homodimer interface [polypeptide binding]; other site 471854007669 active site 471854007670 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 471854007671 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 471854007672 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 471854007673 altronate oxidoreductase; Provisional; Region: PRK03643 471854007674 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 471854007675 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 471854007676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854007677 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471854007678 putative substrate translocation pore; other site 471854007679 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 471854007680 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 471854007681 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 471854007682 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 471854007683 multifunctional aminopeptidase A; Provisional; Region: PRK00913 471854007684 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 471854007685 interface (dimer of trimers) [polypeptide binding]; other site 471854007686 Substrate-binding/catalytic site; other site 471854007687 Zn-binding sites [ion binding]; other site 471854007688 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471854007689 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 471854007690 PA/protease or protease-like domain interface [polypeptide binding]; other site 471854007691 M28 Zn-Peptidases; Region: M28_like_4; cd08015 471854007692 Peptidase family M28; Region: Peptidase_M28; pfam04389 471854007693 metal binding site [ion binding]; metal-binding site 471854007694 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 471854007695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854007696 S-adenosylmethionine binding site [chemical binding]; other site 471854007697 Predicted permeases [General function prediction only]; Region: RarD; COG2962 471854007698 EamA-like transporter family; Region: EamA; pfam00892 471854007699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471854007700 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 471854007701 active site 471854007702 motif I; other site 471854007703 motif II; other site 471854007704 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 471854007705 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471854007706 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471854007707 dimer interface [polypeptide binding]; other site 471854007708 active site 471854007709 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 471854007710 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 471854007711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854007712 NAD(P) binding site [chemical binding]; other site 471854007713 active site 471854007714 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 471854007715 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 471854007716 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 471854007717 Beta-lactamase; Region: Beta-lactamase; pfam00144 471854007718 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471854007719 helicase 45; Provisional; Region: PTZ00424 471854007720 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471854007721 ATP binding site [chemical binding]; other site 471854007722 Mg++ binding site [ion binding]; other site 471854007723 motif III; other site 471854007724 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854007725 nucleotide binding region [chemical binding]; other site 471854007726 ATP-binding site [chemical binding]; other site 471854007727 BNR repeat-like domain; Region: BNR_2; pfam13088 471854007728 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 471854007729 Asp-box motif; other site 471854007730 catalytic site [active] 471854007731 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 471854007732 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 471854007733 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 471854007734 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854007735 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854007736 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854007737 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 471854007738 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 471854007739 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 471854007740 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471854007741 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471854007742 ligand binding site [chemical binding]; other site 471854007743 flexible hinge region; other site 471854007744 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471854007745 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854007746 DNA interaction; other site 471854007747 Metal-binding active site; metal-binding site 471854007748 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854007749 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854007750 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 471854007751 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 471854007752 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471854007753 active site 471854007754 catalytic residues [active] 471854007755 proline aminopeptidase P II; Provisional; Region: PRK10879 471854007756 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 471854007757 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 471854007758 active site 471854007759 MgtC family; Region: MgtC; pfam02308 471854007760 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 471854007761 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854007762 active site 471854007763 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 471854007764 UbiA prenyltransferase family; Region: UbiA; pfam01040 471854007765 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 471854007766 active site 471854007767 metal binding site [ion binding]; metal-binding site 471854007768 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471854007769 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 471854007770 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471854007771 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 471854007772 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 471854007773 active site 471854007774 DivIVA protein; Region: DivIVA; pfam05103 471854007775 DivIVA domain; Region: DivI1A_domain; TIGR03544 471854007776 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 471854007777 FOG: WD40 repeat [General function prediction only]; Region: COG2319 471854007778 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 471854007779 structural tetrad; other site 471854007780 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 471854007781 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 471854007782 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 471854007783 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 471854007784 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 471854007785 NAD binding site [chemical binding]; other site 471854007786 homodimer interface [polypeptide binding]; other site 471854007787 active site 471854007788 substrate binding site [chemical binding]; other site 471854007789 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 471854007790 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 471854007791 NAD binding site [chemical binding]; other site 471854007792 substrate binding site [chemical binding]; other site 471854007793 homodimer interface [polypeptide binding]; other site 471854007794 active site 471854007795 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 471854007796 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 471854007797 substrate binding site; other site 471854007798 tetramer interface; other site 471854007799 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 471854007800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854007801 S-adenosylmethionine binding site [chemical binding]; other site 471854007802 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 471854007803 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471854007804 catalytic residue [active] 471854007805 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 471854007806 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471854007807 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471854007808 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471854007809 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471854007810 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 471854007811 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 471854007812 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471854007813 DNA binding site [nucleotide binding] 471854007814 active site 471854007815 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 471854007816 Na binding site [ion binding]; other site 471854007817 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 471854007818 recombination protein RecR; Reviewed; Region: recR; PRK00076 471854007819 RecR protein; Region: RecR; pfam02132 471854007820 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 471854007821 putative active site [active] 471854007822 putative metal-binding site [ion binding]; other site 471854007823 tetramer interface [polypeptide binding]; other site 471854007824 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 471854007825 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 471854007826 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 471854007827 TPR repeat; Region: TPR_11; pfam13414 471854007828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854007829 binding surface 471854007830 TPR motif; other site 471854007831 TPR repeat; Region: TPR_11; pfam13414 471854007832 TPR repeat; Region: TPR_11; pfam13414 471854007833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854007834 binding surface 471854007835 TPR repeat; Region: TPR_11; pfam13414 471854007836 TPR motif; other site 471854007837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854007838 TPR motif; other site 471854007839 binding surface 471854007840 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471854007841 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471854007842 catalytic residues [active] 471854007843 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 471854007844 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 471854007845 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 471854007846 CoA binding domain; Region: CoA_binding; smart00881 471854007847 CoA-ligase; Region: Ligase_CoA; pfam00549 471854007848 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 471854007849 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 471854007850 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 471854007851 active site 471854007852 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 471854007853 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 471854007854 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 471854007855 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 471854007856 GldM N-terminal domain; Region: GldM_N; pfam12081 471854007857 GldM C-terminal domain; Region: GldM_C; pfam12080 471854007858 gliding motility associated protien GldN; Region: GldN; TIGR03523 471854007859 gliding motility associated protien GldN; Region: GldN; TIGR03523 471854007860 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471854007861 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471854007862 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471854007863 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 471854007864 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 471854007865 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 471854007866 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471854007867 active site residue [active] 471854007868 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854007869 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471854007870 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 471854007871 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471854007872 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 471854007873 Lumazine binding domain; Region: Lum_binding; pfam00677 471854007874 Lumazine binding domain; Region: Lum_binding; pfam00677 471854007875 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 471854007876 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471854007877 active site 471854007878 motif I; other site 471854007879 motif II; other site 471854007880 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 471854007881 putative active site pocket [active] 471854007882 4-fold oligomerization interface [polypeptide binding]; other site 471854007883 metal binding residues [ion binding]; metal-binding site 471854007884 3-fold/trimer interface [polypeptide binding]; other site 471854007885 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 471854007886 active site clefts [active] 471854007887 zinc binding site [ion binding]; other site 471854007888 dimer interface [polypeptide binding]; other site 471854007889 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 471854007890 Sulfate transporter family; Region: Sulfate_transp; pfam00916 471854007891 rod shape-determining protein MreC; Provisional; Region: PRK13922 471854007892 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 471854007893 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854007894 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854007895 DNA binding residues [nucleotide binding] 471854007896 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 471854007897 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471854007898 PYR/PP interface [polypeptide binding]; other site 471854007899 dimer interface [polypeptide binding]; other site 471854007900 TPP binding site [chemical binding]; other site 471854007901 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471854007902 transketolase; Reviewed; Region: PRK05899 471854007903 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 471854007904 TPP-binding site [chemical binding]; other site 471854007905 dimer interface [polypeptide binding]; other site 471854007906 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 471854007907 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 471854007908 catalytic triad [active] 471854007909 Peptidase family M23; Region: Peptidase_M23; pfam01551 471854007910 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471854007911 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471854007912 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 471854007913 NlpC/P60 family; Region: NLPC_P60; pfam00877 471854007914 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 471854007915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471854007916 motif II; other site 471854007917 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854007918 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 471854007919 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 471854007920 dimerization interface [polypeptide binding]; other site 471854007921 DPS ferroxidase diiron center [ion binding]; other site 471854007922 ion pore; other site 471854007923 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 471854007924 homotrimer interaction site [polypeptide binding]; other site 471854007925 zinc binding site [ion binding]; other site 471854007926 CDP-binding sites; other site 471854007927 Amidohydrolase; Region: Amidohydro_2; pfam04909 471854007928 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 471854007929 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471854007930 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471854007931 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471854007932 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471854007933 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471854007934 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471854007935 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854007936 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 471854007937 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854007938 TPR motif; other site 471854007939 binding surface 471854007940 TPR repeat; Region: TPR_11; pfam13414 471854007941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854007942 binding surface 471854007943 TPR motif; other site 471854007944 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854007945 TPR repeat; Region: TPR_11; pfam13414 471854007946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854007947 binding surface 471854007948 TPR motif; other site 471854007949 TPR repeat; Region: TPR_11; pfam13414 471854007950 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854007951 binding surface 471854007952 TPR motif; other site 471854007953 TPR repeat; Region: TPR_11; pfam13414 471854007954 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 471854007955 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 471854007956 putative NADP binding site [chemical binding]; other site 471854007957 putative substrate binding site [chemical binding]; other site 471854007958 active site 471854007959 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 471854007960 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 471854007961 active site 471854007962 HIGH motif; other site 471854007963 KMSKS motif; other site 471854007964 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 471854007965 tRNA binding surface [nucleotide binding]; other site 471854007966 anticodon binding site; other site 471854007967 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 471854007968 dimer interface [polypeptide binding]; other site 471854007969 putative tRNA-binding site [nucleotide binding]; other site 471854007970 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 471854007971 Rdx family; Region: Rdx; cl01407 471854007972 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471854007973 Histidine kinase; Region: HisKA_3; pfam07730 471854007974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854007975 ATP binding site [chemical binding]; other site 471854007976 Mg2+ binding site [ion binding]; other site 471854007977 G-X-G motif; other site 471854007978 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854007979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854007980 active site 471854007981 phosphorylation site [posttranslational modification] 471854007982 intermolecular recognition site; other site 471854007983 dimerization interface [polypeptide binding]; other site 471854007984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854007985 DNA binding residues [nucleotide binding] 471854007986 dimerization interface [polypeptide binding]; other site 471854007987 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 471854007988 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 471854007989 potential catalytic triad [active] 471854007990 conserved cys residue [active] 471854007991 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 471854007992 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 471854007993 active site 471854007994 dimer interface [polypeptide binding]; other site 471854007995 diaminopimelate decarboxylase; Region: lysA; TIGR01048 471854007996 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 471854007997 active site 471854007998 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471854007999 substrate binding site [chemical binding]; other site 471854008000 catalytic residues [active] 471854008001 dimer interface [polypeptide binding]; other site 471854008002 YCII-related domain; Region: YCII; cl00999 471854008003 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 471854008004 Clp amino terminal domain; Region: Clp_N; pfam02861 471854008005 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854008006 Walker A motif; other site 471854008007 ATP binding site [chemical binding]; other site 471854008008 Walker B motif; other site 471854008009 arginine finger; other site 471854008010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854008011 Walker A motif; other site 471854008012 ATP binding site [chemical binding]; other site 471854008013 Walker B motif; other site 471854008014 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 471854008015 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 471854008016 intracellular protease, PfpI family; Region: PfpI; TIGR01382 471854008017 proposed catalytic triad [active] 471854008018 conserved cys residue [active] 471854008019 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 471854008020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854008021 Walker A/P-loop; other site 471854008022 ATP binding site [chemical binding]; other site 471854008023 ABC transporter signature motif; other site 471854008024 Walker B; other site 471854008025 D-loop; other site 471854008026 H-loop/switch region; other site 471854008027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854008028 Walker A/P-loop; other site 471854008029 ATP binding site [chemical binding]; other site 471854008030 Q-loop/lid; other site 471854008031 ABC transporter signature motif; other site 471854008032 Walker B; other site 471854008033 D-loop; other site 471854008034 H-loop/switch region; other site 471854008035 RibD C-terminal domain; Region: RibD_C; cl17279 471854008036 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471854008037 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 471854008038 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 471854008039 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 471854008040 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854008041 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854008042 HEAT repeats; Region: HEAT_2; pfam13646 471854008043 HEAT repeats; Region: HEAT_2; pfam13646 471854008044 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854008045 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854008046 HWE histidine kinase; Region: HWE_HK; cl06527 471854008047 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 471854008048 RES domain; Region: RES; pfam08808 471854008049 Arylesterase; Region: Arylesterase; pfam01731 471854008050 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 471854008051 Protein of unknown function, DUF486; Region: DUF486; cl01236 471854008052 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 471854008053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854008054 putative substrate translocation pore; other site 471854008055 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 471854008056 MutS domain I; Region: MutS_I; pfam01624 471854008057 MutS domain II; Region: MutS_II; pfam05188 471854008058 MutS domain III; Region: MutS_III; pfam05192 471854008059 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 471854008060 Walker A/P-loop; other site 471854008061 ATP binding site [chemical binding]; other site 471854008062 Q-loop/lid; other site 471854008063 ABC transporter signature motif; other site 471854008064 Walker B; other site 471854008065 D-loop; other site 471854008066 H-loop/switch region; other site 471854008067 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 471854008068 pseudouridine synthase; Region: TIGR00093 471854008069 active site 471854008070 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471854008071 putative active site [active] 471854008072 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 471854008073 putative active site [active] 471854008074 putative catalytic site [active] 471854008075 putative DNA binding site [nucleotide binding]; other site 471854008076 putative phosphate binding site [ion binding]; other site 471854008077 metal binding site A [ion binding]; metal-binding site 471854008078 putative AP binding site [nucleotide binding]; other site 471854008079 putative metal binding site B [ion binding]; other site 471854008080 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471854008081 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 471854008082 putative active site [active] 471854008083 putative metal binding site [ion binding]; other site 471854008084 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854008085 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 471854008086 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 471854008087 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 471854008088 CAAX protease self-immunity; Region: Abi; pfam02517 471854008089 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 471854008090 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 471854008091 FMN binding site [chemical binding]; other site 471854008092 active site 471854008093 catalytic residues [active] 471854008094 substrate binding site [chemical binding]; other site 471854008095 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471854008096 carboxyltransferase (CT) interaction site; other site 471854008097 biotinylation site [posttranslational modification]; other site 471854008098 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 471854008099 putative nucleotide binding site [chemical binding]; other site 471854008100 uridine monophosphate binding site [chemical binding]; other site 471854008101 homohexameric interface [polypeptide binding]; other site 471854008102 ribosome recycling factor; Reviewed; Region: frr; PRK00083 471854008103 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 471854008104 hinge region; other site 471854008105 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471854008106 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 471854008107 NAD binding site [chemical binding]; other site 471854008108 putative substrate binding site 2 [chemical binding]; other site 471854008109 putative substrate binding site 1 [chemical binding]; other site 471854008110 active site 471854008111 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 471854008112 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 471854008113 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471854008114 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 471854008115 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471854008116 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 471854008117 FAD binding site [chemical binding]; other site 471854008118 homotetramer interface [polypeptide binding]; other site 471854008119 substrate binding pocket [chemical binding]; other site 471854008120 catalytic base [active] 471854008121 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 471854008122 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 471854008123 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854008124 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 471854008125 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 471854008126 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 471854008127 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471854008128 PglZ domain; Region: PglZ; pfam08665 471854008129 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471854008130 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 471854008131 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471854008132 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471854008133 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471854008134 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471854008135 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471854008136 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471854008137 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 471854008138 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 471854008139 active site 471854008140 Family of unknown function (DUF490); Region: DUF490; pfam04357 471854008141 UGMP family protein; Validated; Region: PRK09604 471854008142 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 471854008143 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 471854008144 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 471854008145 MOSC domain; Region: MOSC; pfam03473 471854008146 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 471854008147 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 471854008148 active site 471854008149 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 471854008150 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 471854008151 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 471854008152 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 471854008153 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 471854008154 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 471854008155 trimer interface [polypeptide binding]; other site 471854008156 active site 471854008157 UDP-GlcNAc binding site [chemical binding]; other site 471854008158 lipid binding site [chemical binding]; lipid-binding site 471854008159 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 471854008160 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471854008161 Zn2+ binding site [ion binding]; other site 471854008162 Mg2+ binding site [ion binding]; other site 471854008163 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 471854008164 DNA-binding site [nucleotide binding]; DNA binding site 471854008165 RNA-binding motif; other site 471854008166 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 471854008167 putative acyl-acceptor binding pocket; other site 471854008168 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 471854008169 catalytic site [active] 471854008170 BNR repeat-like domain; Region: BNR_2; pfam13088 471854008171 Asp-box motif; other site 471854008172 Domain of unknown function (DUF303); Region: DUF303; pfam03629 471854008173 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 471854008174 Kelch motif; Region: Kelch_1; pfam01344 471854008175 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 471854008176 putative transporter; Provisional; Region: PRK10484 471854008177 Na binding site [ion binding]; other site 471854008178 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471854008179 Class I aldolases; Region: Aldolase_Class_I; cl17187 471854008180 catalytic residue [active] 471854008181 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854008182 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854008183 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854008184 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854008185 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854008186 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471854008187 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471854008188 DNA-binding site [nucleotide binding]; DNA binding site 471854008189 FCD domain; Region: FCD; pfam07729 471854008190 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471854008191 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854008192 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 471854008193 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 471854008194 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854008195 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854008196 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854008197 DNA binding residues [nucleotide binding] 471854008198 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854008199 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 471854008200 Cupin domain; Region: Cupin_2; pfam07883 471854008201 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471854008202 classical (c) SDRs; Region: SDR_c; cd05233 471854008203 NAD(P) binding site [chemical binding]; other site 471854008204 active site 471854008205 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 471854008206 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 471854008207 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471854008208 DXD motif; other site 471854008209 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 471854008210 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 471854008211 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 471854008212 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 471854008213 DNA polymerase; Provisional; Region: 43; PHA02528 471854008214 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471854008215 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471854008216 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471854008217 catalytic residue [active] 471854008218 Peptidase family M23; Region: Peptidase_M23; pfam01551 471854008219 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471854008220 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471854008221 active site 471854008222 catalytic tetrad [active] 471854008223 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471854008224 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471854008225 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471854008226 DoxX; Region: DoxX; pfam07681 471854008227 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854008228 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 471854008229 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 471854008230 N-terminal plug; other site 471854008231 ligand-binding site [chemical binding]; other site 471854008232 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 471854008233 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854008234 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 471854008235 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 471854008236 HEAT repeats; Region: HEAT_2; pfam13646 471854008237 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 471854008238 Cytochrome c; Region: Cytochrom_C; pfam00034 471854008239 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 471854008240 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854008241 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 471854008242 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 471854008243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471854008244 FeS/SAM binding site; other site 471854008245 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 471854008246 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 471854008247 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 471854008248 trimer interface [polypeptide binding]; other site 471854008249 dimer interface [polypeptide binding]; other site 471854008250 putative active site [active] 471854008251 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 471854008252 MPT binding site; other site 471854008253 trimer interface [polypeptide binding]; other site 471854008254 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 471854008255 MoaE homodimer interface [polypeptide binding]; other site 471854008256 MoaD interaction [polypeptide binding]; other site 471854008257 active site residues [active] 471854008258 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 471854008259 MoaE interaction surface [polypeptide binding]; other site 471854008260 MoeB interaction surface [polypeptide binding]; other site 471854008261 thiocarboxylated glycine; other site 471854008262 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 471854008263 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471854008264 dimer interface [polypeptide binding]; other site 471854008265 putative functional site; other site 471854008266 putative MPT binding site; other site 471854008267 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 471854008268 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471854008269 catalytic residue [active] 471854008270 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 471854008271 active site 471854008272 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 471854008273 Na binding site [ion binding]; other site 471854008274 substrate binding site [chemical binding]; other site 471854008275 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 471854008276 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 471854008277 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 471854008278 purine monophosphate binding site [chemical binding]; other site 471854008279 dimer interface [polypeptide binding]; other site 471854008280 putative catalytic residues [active] 471854008281 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 471854008282 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 471854008283 short chain dehydrogenase; Provisional; Region: PRK08339 471854008284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854008285 NAD(P) binding site [chemical binding]; other site 471854008286 active site 471854008287 Family description; Region: VCBS; pfam13517 471854008288 Family description; Region: VCBS; pfam13517 471854008289 Family description; Region: VCBS; pfam13517 471854008290 Family description; Region: VCBS; pfam13517 471854008291 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 471854008292 Family description; Region: VCBS; pfam13517 471854008293 Family description; Region: VCBS; pfam13517 471854008294 Family description; Region: VCBS; pfam13517 471854008295 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471854008296 FAD binding domain; Region: FAD_binding_4; pfam01565 471854008297 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 471854008298 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 471854008299 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 471854008300 AAA domain; Region: AAA_14; pfam13173 471854008301 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 471854008302 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854008303 DNA helicase, putative; Region: TIGR00376 471854008304 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471854008305 ATP binding site [chemical binding]; other site 471854008306 putative Mg++ binding site [ion binding]; other site 471854008307 AAA domain; Region: AAA_12; pfam13087 471854008308 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 471854008309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854008310 putative substrate translocation pore; other site 471854008311 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 471854008312 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 471854008313 putative DNA binding site [nucleotide binding]; other site 471854008314 putative homodimer interface [polypeptide binding]; other site 471854008315 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 471854008316 nucleotide binding site [chemical binding]; other site 471854008317 Glyco_18 domain; Region: Glyco_18; smart00636 471854008318 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 471854008319 active site 471854008320 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 471854008321 Active_site [active] 471854008322 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 471854008323 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 471854008324 4-aminobutyrate aminotransferase; Provisional; Region: PRK06082 471854008325 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471854008326 inhibitor-cofactor binding pocket; inhibition site 471854008327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854008328 catalytic residue [active] 471854008329 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471854008330 Sulfatase; Region: Sulfatase; cl17466 471854008331 Fn3 associated; Region: Fn3_assoc; pfam13287 471854008332 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 471854008333 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 471854008334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471854008335 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 471854008336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471854008337 motif II; other site 471854008338 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471854008339 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854008340 non-specific DNA binding site [nucleotide binding]; other site 471854008341 salt bridge; other site 471854008342 sequence-specific DNA binding site [nucleotide binding]; other site 471854008343 Cupin domain; Region: Cupin_2; pfam07883 471854008344 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 471854008345 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 471854008346 tetramer interface [polypeptide binding]; other site 471854008347 active site 471854008348 Mg2+/Mn2+ binding site [ion binding]; other site 471854008349 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 471854008350 Uncharacterized conserved protein [Function unknown]; Region: COG2128 471854008351 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 471854008352 6-phosphofructokinase; Provisional; Region: PRK03202 471854008353 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 471854008354 active site 471854008355 ADP/pyrophosphate binding site [chemical binding]; other site 471854008356 dimerization interface [polypeptide binding]; other site 471854008357 allosteric effector site; other site 471854008358 fructose-1,6-bisphosphate binding site; other site 471854008359 Uncharacterized conserved protein [Function unknown]; Region: COG1434 471854008360 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 471854008361 putative active site [active] 471854008362 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 471854008363 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471854008364 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471854008365 catalytic residues [active] 471854008366 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 471854008367 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 471854008368 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471854008369 metal-binding site [ion binding] 471854008370 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471854008371 Soluble P-type ATPase [General function prediction only]; Region: COG4087 471854008372 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 471854008373 metal-binding site [ion binding] 471854008374 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854008375 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854008376 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854008377 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854008378 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854008379 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471854008380 metal-binding site [ion binding] 471854008381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854008382 S-adenosylmethionine binding site [chemical binding]; other site 471854008383 Sulphur transport; Region: Sulf_transp; pfam04143 471854008384 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 471854008385 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 471854008386 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471854008387 active site residue [active] 471854008388 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471854008389 active site residue [active] 471854008390 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139 471854008391 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 471854008392 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 471854008393 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 471854008394 HflX GTPase family; Region: HflX; cd01878 471854008395 G1 box; other site 471854008396 GTP/Mg2+ binding site [chemical binding]; other site 471854008397 Switch I region; other site 471854008398 G2 box; other site 471854008399 G3 box; other site 471854008400 Switch II region; other site 471854008401 G4 box; other site 471854008402 G5 box; other site 471854008403 Transposase; Region: HTH_Tnp_1; pfam01527 471854008404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 471854008405 HTH-like domain; Region: HTH_21; pfam13276 471854008406 Integrase core domain; Region: rve; pfam00665 471854008407 Integrase core domain; Region: rve_3; pfam13683 471854008408 Uncharacterized conserved protein [Function unknown]; Region: COG4748 471854008409 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 471854008410 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 471854008411 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 471854008412 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471854008413 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 471854008414 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 471854008415 polyol permease family; Region: 2A0118; TIGR00897 471854008416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854008417 putative substrate translocation pore; other site 471854008418 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 471854008419 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 471854008420 putative ligand binding site [chemical binding]; other site 471854008421 putative NAD binding site [chemical binding]; other site 471854008422 catalytic site [active] 471854008423 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 471854008424 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471854008425 nucleotide binding site [chemical binding]; other site 471854008426 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 471854008427 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471854008428 nucleotide binding site [chemical binding]; other site 471854008429 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471854008430 catalytic core [active] 471854008431 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471854008432 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 471854008433 putative active site [active] 471854008434 catalytic site [active] 471854008435 putative metal binding site [ion binding]; other site 471854008436 oligomer interface [polypeptide binding]; other site 471854008437 Transcriptional regulator PadR-like family; Region: PadR; cl17335 471854008438 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471854008439 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471854008440 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 471854008441 prephenate dehydrogenase; Validated; Region: PRK08507 471854008442 Prephenate dehydrogenase; Region: PDH; pfam02153 471854008443 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 471854008444 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471854008445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854008446 homodimer interface [polypeptide binding]; other site 471854008447 catalytic residue [active] 471854008448 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 471854008449 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471854008450 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 471854008451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471854008452 dimer interface [polypeptide binding]; other site 471854008453 conserved gate region; other site 471854008454 putative PBP binding loops; other site 471854008455 ABC-ATPase subunit interface; other site 471854008456 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 471854008457 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 471854008458 Walker A/P-loop; other site 471854008459 ATP binding site [chemical binding]; other site 471854008460 Q-loop/lid; other site 471854008461 ABC transporter signature motif; other site 471854008462 Walker B; other site 471854008463 D-loop; other site 471854008464 H-loop/switch region; other site 471854008465 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 471854008466 active site 471854008467 catalytic triad [active] 471854008468 oxyanion hole [active] 471854008469 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008470 Family description; Region: VCBS; pfam13517 471854008471 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008472 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008473 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008474 Family description; Region: VCBS; pfam13517 471854008475 FG-GAP repeat; Region: FG-GAP; cl15299 471854008476 Family description; Region: VCBS; pfam13517 471854008477 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008478 Family description; Region: VCBS; pfam13517 471854008479 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008480 Family description; Region: VCBS; pfam13517 471854008481 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008482 Family description; Region: VCBS; pfam13517 471854008483 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008484 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008485 Family description; Region: VCBS; pfam13517 471854008486 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008487 Family description; Region: VCBS; pfam13517 471854008488 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008489 Family description; Region: VCBS; pfam13517 471854008490 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008491 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854008492 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008493 Family description; Region: VCBS; pfam13517 471854008494 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008495 Family description; Region: VCBS; pfam13517 471854008496 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008497 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008498 Family description; Region: VCBS; pfam13517 471854008499 FG-GAP repeat; Region: FG-GAP; cl15299 471854008500 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008501 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008502 Family description; Region: VCBS; pfam13517 471854008503 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008504 Family description; Region: VCBS; pfam13517 471854008505 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008506 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008507 Family description; Region: VCBS; pfam13517 471854008508 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008509 Family description; Region: VCBS; pfam13517 471854008510 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008511 Family description; Region: VCBS; pfam13517 471854008512 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008513 Family description; Region: VCBS; pfam13517 471854008514 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008515 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854008516 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471854008517 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471854008518 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471854008519 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008520 Family description; Region: VCBS; pfam13517 471854008521 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008522 Family description; Region: VCBS; pfam13517 471854008523 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008524 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008525 Family description; Region: VCBS; pfam13517 471854008526 FG-GAP repeat; Region: FG-GAP; cl15299 471854008527 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008528 Family description; Region: VCBS; pfam13517 471854008529 FG-GAP repeat; Region: FG-GAP; cl15299 471854008530 Family description; Region: VCBS; pfam13517 471854008531 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008532 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008533 Family description; Region: VCBS; pfam13517 471854008534 Family description; Region: VCBS; pfam13517 471854008535 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008536 Family description; Region: VCBS; pfam13517 471854008537 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 471854008538 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854008539 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471854008540 active site 471854008541 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 471854008542 homoserine kinase; Provisional; Region: PRK01212 471854008543 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 471854008544 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 471854008545 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 471854008546 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 471854008547 putative catalytic residues [active] 471854008548 nucleotide binding site [chemical binding]; other site 471854008549 aspartate binding site [chemical binding]; other site 471854008550 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 471854008551 dimer interface [polypeptide binding]; other site 471854008552 putative threonine allosteric regulatory site; other site 471854008553 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 471854008554 putative threonine allosteric regulatory site; other site 471854008555 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 471854008556 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 471854008557 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471854008558 FAD binding domain; Region: FAD_binding_4; pfam01565 471854008559 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471854008560 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471854008561 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854008562 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854008563 dimer interface [polypeptide binding]; other site 471854008564 phosphorylation site [posttranslational modification] 471854008565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854008566 ATP binding site [chemical binding]; other site 471854008567 Mg2+ binding site [ion binding]; other site 471854008568 G-X-G motif; other site 471854008569 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471854008570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854008571 active site 471854008572 phosphorylation site [posttranslational modification] 471854008573 intermolecular recognition site; other site 471854008574 dimerization interface [polypeptide binding]; other site 471854008575 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471854008576 DNA binding site [nucleotide binding] 471854008577 Outer membrane efflux protein; Region: OEP; pfam02321 471854008578 Outer membrane efflux protein; Region: OEP; pfam02321 471854008579 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 471854008580 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854008581 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854008582 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854008583 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 471854008584 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854008585 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854008586 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 471854008587 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 471854008588 putative ligand binding site [chemical binding]; other site 471854008589 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471854008590 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471854008591 TM-ABC transporter signature motif; other site 471854008592 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 471854008593 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 471854008594 Walker A/P-loop; other site 471854008595 ATP binding site [chemical binding]; other site 471854008596 Q-loop/lid; other site 471854008597 ABC transporter signature motif; other site 471854008598 Walker B; other site 471854008599 D-loop; other site 471854008600 H-loop/switch region; other site 471854008601 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 471854008602 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854008603 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854008604 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471854008605 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854008606 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 471854008607 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 471854008608 active site 471854008609 catalytic residues [active] 471854008610 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471854008611 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854008612 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471854008613 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471854008614 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471854008615 DNA interaction; other site 471854008616 Metal-binding active site; metal-binding site 471854008617 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854008618 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 471854008619 active site 471854008620 YceI-like domain; Region: YceI; pfam04264 471854008621 Serine hydrolase; Region: Ser_hydrolase; pfam06821 471854008622 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471854008623 Uncharacterized conserved protein [Function unknown]; Region: COG1262 471854008624 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 471854008625 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 471854008626 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471854008627 Sulfatase; Region: Sulfatase; cl17466 471854008628 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471854008629 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 471854008630 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471854008631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854008632 active site 471854008633 phosphorylation site [posttranslational modification] 471854008634 intermolecular recognition site; other site 471854008635 dimerization interface [polypeptide binding]; other site 471854008636 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 471854008637 heme binding pocket [chemical binding]; other site 471854008638 heme ligand [chemical binding]; other site 471854008639 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 471854008640 GAF domain; Region: GAF; pfam01590 471854008641 Phytochrome region; Region: PHY; pfam00360 471854008642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854008643 phosphorylation site [posttranslational modification] 471854008644 dimer interface [polypeptide binding]; other site 471854008645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854008646 ATP binding site [chemical binding]; other site 471854008647 Mg2+ binding site [ion binding]; other site 471854008648 G-X-G motif; other site 471854008649 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 471854008650 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 471854008651 active site 471854008652 DNA binding site [nucleotide binding] 471854008653 Int/Topo IB signature motif; other site 471854008654 catalytic residues [active] 471854008655 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 471854008656 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 471854008657 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 471854008658 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 471854008659 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471854008660 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 471854008661 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 471854008662 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 471854008663 quinone interaction residues [chemical binding]; other site 471854008664 active site 471854008665 catalytic residues [active] 471854008666 FMN binding site [chemical binding]; other site 471854008667 substrate binding site [chemical binding]; other site 471854008668 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 471854008669 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 471854008670 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 471854008671 active site 471854008672 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854008673 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854008674 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 471854008675 Family of unknown function (DUF490); Region: DUF490; pfam04357 471854008676 Family of unknown function (DUF490); Region: DUF490; pfam04357 471854008677 Surface antigen; Region: Bac_surface_Ag; pfam01103 471854008678 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 471854008679 dimer interface [polypeptide binding]; other site 471854008680 substrate binding site [chemical binding]; other site 471854008681 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854008682 metal binding site [ion binding]; metal-binding site 471854008683 GTPase RsgA; Reviewed; Region: PRK00098 471854008684 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 471854008685 RNA binding site [nucleotide binding]; other site 471854008686 homodimer interface [polypeptide binding]; other site 471854008687 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 471854008688 GTPase/Zn-binding domain interface [polypeptide binding]; other site 471854008689 GTP/Mg2+ binding site [chemical binding]; other site 471854008690 G4 box; other site 471854008691 G5 box; other site 471854008692 G1 box; other site 471854008693 Switch I region; other site 471854008694 G2 box; other site 471854008695 G3 box; other site 471854008696 Switch II region; other site 471854008697 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 471854008698 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471854008699 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471854008700 nucleotide binding site [chemical binding]; other site 471854008701 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 471854008702 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 471854008703 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 471854008704 active site 471854008705 lipoyl synthase; Provisional; Region: PRK05481 471854008706 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471854008707 FeS/SAM binding site; other site 471854008708 S-adenosylmethionine synthetase; Validated; Region: PRK05250 471854008709 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 471854008710 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 471854008711 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 471854008712 Fatty acid desaturase; Region: FA_desaturase; pfam00487 471854008713 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 471854008714 putative di-iron ligands [ion binding]; other site 471854008715 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 471854008716 PIN domain; Region: PIN_3; pfam13470 471854008717 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 471854008718 Protein export membrane protein; Region: SecD_SecF; cl14618 471854008719 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854008720 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854008721 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854008722 MG2 domain; Region: A2M_N; pfam01835 471854008723 Alpha-2-macroglobulin family; Region: A2M; pfam00207 471854008724 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 471854008725 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 471854008726 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471854008727 inhibitor-cofactor binding pocket; inhibition site 471854008728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854008729 catalytic residue [active] 471854008730 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 471854008731 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471854008732 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 471854008733 putative active site [active] 471854008734 catalytic site [active] 471854008735 putative metal binding site [ion binding]; other site 471854008736 oligomer interface [polypeptide binding]; other site 471854008737 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471854008738 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 471854008739 active site 471854008740 metal binding site [ion binding]; metal-binding site 471854008741 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471854008742 active site 471854008743 metal binding site [ion binding]; metal-binding site 471854008744 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; pfam10142 471854008745 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471854008746 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 471854008747 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 471854008748 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854008749 Der GTPase activator (YihI); Region: YihI; cl01172 471854008750 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854008751 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854008752 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854008753 Double-stranded DNA-binding domain; Region: dsDNA_bind; cl00928 471854008754 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 471854008755 Surface antigen; Region: Bac_surface_Ag; pfam01103 471854008756 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 471854008757 active site 471854008758 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 471854008759 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 471854008760 NADP binding site [chemical binding]; other site 471854008761 active site 471854008762 putative substrate binding site [chemical binding]; other site 471854008763 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471854008764 putative active site [active] 471854008765 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471854008766 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 471854008767 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854008768 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471854008769 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854008770 FecR protein; Region: FecR; pfam04773 471854008771 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854008772 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 471854008773 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 471854008774 N-terminal plug; other site 471854008775 ligand-binding site [chemical binding]; other site 471854008776 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854008777 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854008778 PA14 domain; Region: PA14; cl08459 471854008779 Cytochrome c; Region: Cytochrom_C; cl11414 471854008780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854008781 dimer interface [polypeptide binding]; other site 471854008782 phosphorylation site [posttranslational modification] 471854008783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854008784 ATP binding site [chemical binding]; other site 471854008785 Mg2+ binding site [ion binding]; other site 471854008786 G-X-G motif; other site 471854008787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854008788 active site 471854008789 phosphorylation site [posttranslational modification] 471854008790 intermolecular recognition site; other site 471854008791 dimerization interface [polypeptide binding]; other site 471854008792 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 471854008793 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 471854008794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854008795 active site 471854008796 phosphorylation site [posttranslational modification] 471854008797 intermolecular recognition site; other site 471854008798 dimerization interface [polypeptide binding]; other site 471854008799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854008800 Walker A motif; other site 471854008801 ATP binding site [chemical binding]; other site 471854008802 Walker B motif; other site 471854008803 arginine finger; other site 471854008804 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 471854008805 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 471854008806 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 471854008807 dinuclear metal binding motif [ion binding]; other site 471854008808 Ferritin-like domain; Region: Ferritin_2; pfam13668 471854008809 sulfite oxidase; Provisional; Region: PLN00177 471854008810 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 471854008811 Moco binding site; other site 471854008812 metal coordination site [ion binding]; other site 471854008813 dimerization interface [polypeptide binding]; other site 471854008814 quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908 471854008815 Staphylococcal nuclease homologues; Region: SNc; smart00318 471854008816 Catalytic site; other site 471854008817 Staphylococcal nuclease homologue; Region: SNase; pfam00565 471854008818 rad50; Region: rad50; TIGR00606 471854008819 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471854008820 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471854008821 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 471854008822 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 471854008823 acyl-activating enzyme (AAE) consensus motif; other site 471854008824 putative AMP binding site [chemical binding]; other site 471854008825 putative active site [active] 471854008826 putative CoA binding site [chemical binding]; other site 471854008827 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 471854008828 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471854008829 nucleophilic elbow; other site 471854008830 catalytic triad; other site 471854008831 Secretory lipase; Region: LIP; pfam03583 471854008832 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471854008833 cysteine synthase B; Region: cysM; TIGR01138 471854008834 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 471854008835 dimer interface [polypeptide binding]; other site 471854008836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854008837 catalytic residue [active] 471854008838 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 471854008839 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 471854008840 30S subunit binding site; other site 471854008841 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 471854008842 dimer interaction site [polypeptide binding]; other site 471854008843 substrate-binding tunnel; other site 471854008844 active site 471854008845 catalytic site [active] 471854008846 substrate binding site [chemical binding]; other site 471854008847 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 471854008848 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471854008849 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471854008850 catalytic residue [active] 471854008851 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 471854008852 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471854008853 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 471854008854 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 471854008855 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 471854008856 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 471854008857 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 471854008858 substrate binding site; other site 471854008859 dimer interface; other site 471854008860 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 471854008861 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 471854008862 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 471854008863 active site 471854008864 trimer interface [polypeptide binding]; other site 471854008865 allosteric site; other site 471854008866 active site lid [active] 471854008867 hexamer (dimer of trimers) interface [polypeptide binding]; other site 471854008868 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854008869 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854008870 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471854008871 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471854008872 DNA binding site [nucleotide binding] 471854008873 domain linker motif; other site 471854008874 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471854008875 ligand binding site [chemical binding]; other site 471854008876 dimerization interface [polypeptide binding]; other site 471854008877 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 471854008878 ATP cone domain; Region: ATP-cone; pfam03477 471854008879 Class I ribonucleotide reductase; Region: RNR_I; cd01679 471854008880 active site 471854008881 dimer interface [polypeptide binding]; other site 471854008882 catalytic residues [active] 471854008883 effector binding site; other site 471854008884 R2 peptide binding site; other site 471854008885 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471854008886 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 471854008887 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 471854008888 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 471854008889 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 471854008890 putative trimer interface [polypeptide binding]; other site 471854008891 putative CoA binding site [chemical binding]; other site 471854008892 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 471854008893 DNA polymerase III subunit delta'; Validated; Region: PRK05564 471854008894 DNA polymerase III subunit delta'; Validated; Region: PRK08485 471854008895 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 471854008896 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 471854008897 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471854008898 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 471854008899 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471854008900 hydrophobic ligand binding site; other site 471854008901 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 471854008902 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 471854008903 domain interfaces; other site 471854008904 active site 471854008905 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854008906 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854008907 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854008908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471854008909 Histidine kinase; Region: His_kinase; pfam06580 471854008910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471854008911 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854008912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854008913 active site 471854008914 phosphorylation site [posttranslational modification] 471854008915 intermolecular recognition site; other site 471854008916 dimerization interface [polypeptide binding]; other site 471854008917 LytTr DNA-binding domain; Region: LytTR; smart00850 471854008918 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 471854008919 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471854008920 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471854008921 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 471854008922 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854008923 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854008924 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854008925 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854008926 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854008927 SusD family; Region: SusD; pfam07980 471854008928 Uncharacterized conserved protein [Function unknown]; Region: COG1739 471854008929 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 471854008930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854008931 H+ Antiporter protein; Region: 2A0121; TIGR00900 471854008932 putative substrate translocation pore; other site 471854008933 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 471854008934 Mg2+ transporter Helicobacter pylori CorA-like subgroup; Region: HpCorA-like; cd12836 471854008935 Cl binding site [ion binding]; other site 471854008936 oligomer interface [polypeptide binding]; other site 471854008937 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471854008938 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 471854008939 Probable Catalytic site; other site 471854008940 metal-binding site 471854008941 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 471854008942 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854008943 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 471854008944 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 471854008945 dimer interface [polypeptide binding]; other site 471854008946 putative radical transfer pathway; other site 471854008947 diiron center [ion binding]; other site 471854008948 tyrosyl radical; other site 471854008949 RecX family; Region: RecX; pfam02631 471854008950 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471854008951 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471854008952 active site 471854008953 metal binding site [ion binding]; metal-binding site 471854008954 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 471854008955 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 471854008956 active site 471854008957 HIGH motif; other site 471854008958 dimer interface [polypeptide binding]; other site 471854008959 KMSKS motif; other site 471854008960 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471854008961 RNA binding surface [nucleotide binding]; other site 471854008962 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 471854008963 active site 471854008964 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 471854008965 sugar binding site [chemical binding]; other site 471854008966 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471854008967 putative active site [active] 471854008968 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 471854008969 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 471854008970 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 471854008971 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 471854008972 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 471854008973 homodimer interface [polypeptide binding]; other site 471854008974 substrate-cofactor binding pocket; other site 471854008975 catalytic residue [active] 471854008976 Cupin domain; Region: Cupin_2; cl17218 471854008977 Protein of unknown function DUF72; Region: DUF72; pfam01904 471854008978 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854008979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854008980 Coenzyme A binding pocket [chemical binding]; other site 471854008981 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 471854008982 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 471854008983 ABC1 family; Region: ABC1; cl17513 471854008984 COQ9; Region: COQ9; pfam08511 471854008985 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 471854008986 FAD binding domain; Region: FAD_binding_4; pfam01565 471854008987 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 471854008988 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471854008989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471854008990 DNA-binding site [nucleotide binding]; DNA binding site 471854008991 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471854008992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854008993 homodimer interface [polypeptide binding]; other site 471854008994 catalytic residue [active] 471854008995 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 471854008996 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 471854008997 N-terminal plug; other site 471854008998 ligand-binding site [chemical binding]; other site 471854008999 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 471854009000 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 471854009001 NAD(P) binding site [chemical binding]; other site 471854009002 hypothetical protein; Provisional; Region: PRK11770 471854009003 Domain of unknown function (DUF307); Region: DUF307; pfam03733 471854009004 Domain of unknown function (DUF307); Region: DUF307; pfam03733 471854009005 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 471854009006 pseudouridine synthase; Region: TIGR00093 471854009007 active site 471854009008 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 471854009009 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 471854009010 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 471854009011 FIST N domain; Region: FIST; pfam08495 471854009012 Uncharacterized conserved protein [Function unknown]; Region: COG3287 471854009013 FIST C domain; Region: FIST_C; pfam10442 471854009014 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471854009015 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854009016 putative active site [active] 471854009017 heme pocket [chemical binding]; other site 471854009018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854009019 dimer interface [polypeptide binding]; other site 471854009020 phosphorylation site [posttranslational modification] 471854009021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854009022 ATP binding site [chemical binding]; other site 471854009023 Mg2+ binding site [ion binding]; other site 471854009024 G-X-G motif; other site 471854009025 Response regulator receiver domain; Region: Response_reg; pfam00072 471854009026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854009027 active site 471854009028 phosphorylation site [posttranslational modification] 471854009029 intermolecular recognition site; other site 471854009030 dimerization interface [polypeptide binding]; other site 471854009031 Response regulator receiver domain; Region: Response_reg; pfam00072 471854009032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854009033 active site 471854009034 phosphorylation site [posttranslational modification] 471854009035 intermolecular recognition site; other site 471854009036 dimerization interface [polypeptide binding]; other site 471854009037 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854009038 PAS fold; Region: PAS_3; pfam08447 471854009039 putative active site [active] 471854009040 heme pocket [chemical binding]; other site 471854009041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854009042 dimer interface [polypeptide binding]; other site 471854009043 phosphorylation site [posttranslational modification] 471854009044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854009045 ATP binding site [chemical binding]; other site 471854009046 Mg2+ binding site [ion binding]; other site 471854009047 G-X-G motif; other site 471854009048 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471854009049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854009050 active site 471854009051 phosphorylation site [posttranslational modification] 471854009052 intermolecular recognition site; other site 471854009053 dimerization interface [polypeptide binding]; other site 471854009054 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471854009055 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471854009056 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471854009057 AAA domain; Region: AAA_14; pfam13173 471854009058 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 471854009059 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 471854009060 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471854009061 putative active site [active] 471854009062 putative metal binding site [ion binding]; other site 471854009063 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 471854009064 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471854009065 ATP binding site [chemical binding]; other site 471854009066 putative Mg++ binding site [ion binding]; other site 471854009067 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854009068 nucleotide binding region [chemical binding]; other site 471854009069 ATP-binding site [chemical binding]; other site 471854009070 DEAD/H associated; Region: DEAD_assoc; pfam08494 471854009071 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471854009072 ATP-dependent DNA ligase; Validated; Region: PRK09247 471854009073 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 471854009074 active site 471854009075 DNA binding site [nucleotide binding] 471854009076 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 471854009077 DNA binding site [nucleotide binding] 471854009078 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 471854009079 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471854009080 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 471854009081 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471854009082 intersubunit interface [polypeptide binding]; other site 471854009083 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471854009084 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471854009085 ABC-ATPase subunit interface; other site 471854009086 dimer interface [polypeptide binding]; other site 471854009087 putative PBP binding regions; other site 471854009088 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471854009089 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471854009090 Walker A/P-loop; other site 471854009091 ATP binding site [chemical binding]; other site 471854009092 Q-loop/lid; other site 471854009093 ABC transporter signature motif; other site 471854009094 Walker B; other site 471854009095 D-loop; other site 471854009096 H-loop/switch region; other site 471854009097 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471854009098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854009099 Coenzyme A binding pocket [chemical binding]; other site 471854009100 Predicted amidohydrolase [General function prediction only]; Region: COG0388 471854009101 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 471854009102 putative active site [active] 471854009103 catalytic triad [active] 471854009104 putative dimer interface [polypeptide binding]; other site 471854009105 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 471854009106 trimer interface [polypeptide binding]; other site 471854009107 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 471854009108 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 471854009109 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 471854009110 trimer interface [polypeptide binding]; other site 471854009111 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 471854009112 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854009113 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 471854009114 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471854009115 Cytochrome c; Region: Cytochrom_C; pfam00034 471854009116 dihydroorotase; Provisional; Region: PRK09237 471854009117 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854009118 active site 471854009119 dihydroorotase; Provisional; Region: PRK09237 471854009120 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854009121 active site 471854009122 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 471854009123 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 471854009124 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 471854009125 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 471854009126 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 471854009127 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471854009128 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471854009129 active site 471854009130 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 471854009131 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 471854009132 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 471854009133 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471854009134 ligand binding site [chemical binding]; other site 471854009135 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 471854009136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471854009137 UDP-galactopyranose mutase; Region: GLF; pfam03275 471854009138 Chain length determinant protein; Region: Wzz; pfam02706 471854009139 tyrosine kinase; Provisional; Region: PRK11519 471854009140 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 471854009141 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 471854009142 NeuB family; Region: NeuB; pfam03102 471854009143 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 471854009144 NeuB binding interface [polypeptide binding]; other site 471854009145 putative substrate binding site [chemical binding]; other site 471854009146 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 471854009147 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 471854009148 active site 471854009149 homodimer interface [polypeptide binding]; other site 471854009150 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 471854009151 ligand binding site; other site 471854009152 tetramer interface; other site 471854009153 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 471854009154 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 471854009155 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471854009156 DNA primase, catalytic core; Region: dnaG; TIGR01391 471854009157 CHC2 zinc finger; Region: zf-CHC2; pfam01807 471854009158 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 471854009159 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 471854009160 active site 471854009161 metal binding site [ion binding]; metal-binding site 471854009162 interdomain interaction site; other site 471854009163 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 471854009164 YtxH-like protein; Region: YtxH; pfam12732 471854009165 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 471854009166 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 471854009167 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471854009168 para-aminobenzoate synthase component I; Validated; Region: PRK07093 471854009169 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 471854009170 hypothetical protein; Provisional; Region: PRK07101 471854009171 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471854009172 primosomal protein N' Region: priA; TIGR00595 471854009173 ATP binding site [chemical binding]; other site 471854009174 putative Mg++ binding site [ion binding]; other site 471854009175 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 471854009176 helicase superfamily c-terminal domain; Region: HELICc; smart00490 471854009177 ATP-binding site [chemical binding]; other site 471854009178 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 471854009179 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 471854009180 domain interfaces; other site 471854009181 active site 471854009182 Penicillinase repressor; Region: Pencillinase_R; pfam03965 471854009183 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 471854009184 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 471854009185 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854009186 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 471854009187 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854009188 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 471854009189 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 471854009190 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854009191 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854009192 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471854009193 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 471854009194 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 471854009195 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 471854009196 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471854009197 putative active site [active] 471854009198 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 471854009199 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 471854009200 signal recognition particle protein; Provisional; Region: PRK10867 471854009201 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 471854009202 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 471854009203 P loop; other site 471854009204 GTP binding site [chemical binding]; other site 471854009205 Signal peptide binding domain; Region: SRP_SPB; pfam02978 471854009206 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 471854009207 Sulfatase; Region: Sulfatase; cl17466 471854009208 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 471854009209 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471854009210 TraB family; Region: TraB; pfam01963 471854009211 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471854009212 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 471854009213 PA/protease or protease-like domain interface [polypeptide binding]; other site 471854009214 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 471854009215 Peptidase family M28; Region: Peptidase_M28; pfam04389 471854009216 metal binding site [ion binding]; metal-binding site 471854009217 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 471854009218 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 471854009219 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 471854009220 G1 box; other site 471854009221 putative GEF interaction site [polypeptide binding]; other site 471854009222 GTP/Mg2+ binding site [chemical binding]; other site 471854009223 Switch I region; other site 471854009224 G2 box; other site 471854009225 G3 box; other site 471854009226 Switch II region; other site 471854009227 G4 box; other site 471854009228 G5 box; other site 471854009229 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 471854009230 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 471854009231 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 471854009232 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471854009233 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 471854009234 NAD(P) binding site [chemical binding]; other site 471854009235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854009236 dimer interface [polypeptide binding]; other site 471854009237 phosphorylation site [posttranslational modification] 471854009238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854009239 ATP binding site [chemical binding]; other site 471854009240 Mg2+ binding site [ion binding]; other site 471854009241 G-X-G motif; other site 471854009242 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 471854009243 acyl-CoA synthetase; Validated; Region: PRK05850 471854009244 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 471854009245 acyl-activating enzyme (AAE) consensus motif; other site 471854009246 active site 471854009247 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 471854009248 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 471854009249 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 471854009250 Na binding site [ion binding]; other site 471854009251 putative glycosylation site [posttranslational modification]; other site 471854009252 putative glycosylation site [posttranslational modification]; other site 471854009253 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 471854009254 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 471854009255 TrkA-N domain; Region: TrkA_N; pfam02254 471854009256 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 471854009257 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 471854009258 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471854009259 NADP binding site [chemical binding]; other site 471854009260 dimer interface [polypeptide binding]; other site 471854009261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471854009262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471854009263 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471854009264 classical (c) SDRs; Region: SDR_c; cd05233 471854009265 NAD(P) binding site [chemical binding]; other site 471854009266 active site 471854009267 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471854009268 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471854009269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854009270 S-adenosylmethionine binding site [chemical binding]; other site 471854009271 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 471854009272 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 471854009273 Ligand binding site; other site 471854009274 Putative Catalytic site; other site 471854009275 DXD motif; other site 471854009276 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 471854009277 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471854009278 inhibitor-cofactor binding pocket; inhibition site 471854009279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854009280 catalytic residue [active] 471854009281 WxcM-like, C-terminal; Region: FdtA; pfam05523 471854009282 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 471854009283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854009284 Walker A/P-loop; other site 471854009285 ATP binding site [chemical binding]; other site 471854009286 Q-loop/lid; other site 471854009287 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 471854009288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854009289 ABC transporter signature motif; other site 471854009290 Walker B; other site 471854009291 D-loop; other site 471854009292 H-loop/switch region; other site 471854009293 GH3 auxin-responsive promoter; Region: GH3; pfam03321 471854009294 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 471854009295 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471854009296 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 471854009297 Catalytic dyad [active] 471854009298 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 471854009299 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471854009300 inhibitor-cofactor binding pocket; inhibition site 471854009301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854009302 catalytic residue [active] 471854009303 Putative addiction module component; Region: Unstab_antitox; cl09921 471854009304 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 471854009305 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854009306 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854009307 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854009308 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 471854009309 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 471854009310 substrate binding site [chemical binding]; other site 471854009311 active site 471854009312 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 471854009313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471854009314 active site 471854009315 motif I; other site 471854009316 motif II; other site 471854009317 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 471854009318 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 471854009319 dimer interface [polypeptide binding]; other site 471854009320 active site 471854009321 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471854009322 catalytic residues [active] 471854009323 substrate binding site [chemical binding]; other site 471854009324 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471854009325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471854009326 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 471854009327 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854009328 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854009329 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854009330 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 471854009331 Protein export membrane protein; Region: SecD_SecF; cl14618 471854009332 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471854009333 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 471854009334 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 471854009335 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854009336 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 471854009337 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854009338 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471854009339 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471854009340 Metal-binding active site; metal-binding site 471854009341 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 471854009342 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854009343 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 471854009344 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854009345 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 471854009346 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854009347 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 471854009348 active site 471854009349 K+ potassium transporter; Region: K_trans; pfam02705 471854009350 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 471854009351 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471854009352 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 471854009353 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471854009354 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471854009355 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 471854009356 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 471854009357 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 471854009358 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 471854009359 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 471854009360 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 471854009361 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 471854009362 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 471854009363 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 471854009364 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 471854009365 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 471854009366 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 471854009367 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 471854009368 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 471854009369 DNA binding site [nucleotide binding] 471854009370 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 471854009371 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 471854009372 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 471854009373 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 471854009374 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471854009375 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 471854009376 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471854009377 RPB3 interaction site [polypeptide binding]; other site 471854009378 RPB1 interaction site [polypeptide binding]; other site 471854009379 RPB11 interaction site [polypeptide binding]; other site 471854009380 RPB10 interaction site [polypeptide binding]; other site 471854009381 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 471854009382 core dimer interface [polypeptide binding]; other site 471854009383 peripheral dimer interface [polypeptide binding]; other site 471854009384 L10 interface [polypeptide binding]; other site 471854009385 L11 interface [polypeptide binding]; other site 471854009386 putative EF-Tu interaction site [polypeptide binding]; other site 471854009387 putative EF-G interaction site [polypeptide binding]; other site 471854009388 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 471854009389 23S rRNA interface [nucleotide binding]; other site 471854009390 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 471854009391 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 471854009392 mRNA/rRNA interface [nucleotide binding]; other site 471854009393 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 471854009394 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 471854009395 23S rRNA interface [nucleotide binding]; other site 471854009396 L7/L12 interface [polypeptide binding]; other site 471854009397 putative thiostrepton binding site; other site 471854009398 L25 interface [polypeptide binding]; other site 471854009399 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 471854009400 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 471854009401 putative homodimer interface [polypeptide binding]; other site 471854009402 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 471854009403 heterodimer interface [polypeptide binding]; other site 471854009404 homodimer interface [polypeptide binding]; other site 471854009405 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 471854009406 elongation factor Tu; Reviewed; Region: PRK12735 471854009407 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 471854009408 G1 box; other site 471854009409 GEF interaction site [polypeptide binding]; other site 471854009410 GTP/Mg2+ binding site [chemical binding]; other site 471854009411 Switch I region; other site 471854009412 G2 box; other site 471854009413 G3 box; other site 471854009414 Switch II region; other site 471854009415 G4 box; other site 471854009416 G5 box; other site 471854009417 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 471854009418 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 471854009419 Antibiotic Binding Site [chemical binding]; other site 471854009420 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854009421 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854009422 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854009423 DNA binding residues [nucleotide binding] 471854009424 glutamate racemase; Provisional; Region: PRK00865 471854009425 Protein of unknown function (DUF420); Region: DUF420; pfam04238 471854009426 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 471854009427 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 471854009428 Subunit I/III interface [polypeptide binding]; other site 471854009429 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 471854009430 Subunit I/III interface [polypeptide binding]; other site 471854009431 protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473 471854009432 UbiA prenyltransferase family; Region: UbiA; pfam01040 471854009433 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 471854009434 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 471854009435 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 471854009436 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 471854009437 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 471854009438 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 471854009439 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 471854009440 Cytochrome c; Region: Cytochrom_C; pfam00034 471854009441 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 471854009442 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 471854009443 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 471854009444 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471854009445 molybdopterin cofactor binding site; other site 471854009446 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 471854009447 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 471854009448 4Fe-4S binding domain; Region: Fer4; cl02805 471854009449 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471854009450 Cytochrome c; Region: Cytochrom_C; pfam00034 471854009451 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 471854009452 heme-binding residues [chemical binding]; other site 471854009453 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 471854009454 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 471854009455 RNA binding site [nucleotide binding]; other site 471854009456 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 471854009457 RNA binding site [nucleotide binding]; other site 471854009458 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 471854009459 RNA binding site [nucleotide binding]; other site 471854009460 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471854009461 RNA binding site [nucleotide binding]; other site 471854009462 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471854009463 RNA binding site [nucleotide binding]; other site 471854009464 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 471854009465 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 471854009466 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471854009467 active site 471854009468 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 471854009469 SmpB-tmRNA interface; other site 471854009470 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 471854009471 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 471854009472 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 471854009473 Predicted flavoprotein [General function prediction only]; Region: COG0431 471854009474 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471854009475 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 471854009476 nucleotide binding site [chemical binding]; other site 471854009477 SulA interaction site; other site 471854009478 cell division protein FtsA; Region: ftsA; TIGR01174 471854009479 Cell division protein FtsA; Region: FtsA; smart00842 471854009480 Cell division protein FtsA; Region: FtsA; pfam14450 471854009481 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 471854009482 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 471854009483 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471854009484 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471854009485 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471854009486 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 471854009487 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 471854009488 active site 471854009489 homodimer interface [polypeptide binding]; other site 471854009490 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 471854009491 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 471854009492 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 471854009493 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471854009494 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471854009495 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 471854009496 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 471854009497 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 471854009498 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 471854009499 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854009500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 471854009501 DNA binding residues [nucleotide binding] 471854009502 elongation factor Ts; Provisional; Region: tsf; PRK09377 471854009503 UBA/TS-N domain; Region: UBA; pfam00627 471854009504 Elongation factor TS; Region: EF_TS; pfam00889 471854009505 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 471854009506 rRNA interaction site [nucleotide binding]; other site 471854009507 S8 interaction site; other site 471854009508 putative laminin-1 binding site; other site 471854009509 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 471854009510 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 471854009511 23S rRNA interface [nucleotide binding]; other site 471854009512 L3 interface [polypeptide binding]; other site 471854009513 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854009514 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 471854009515 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 471854009516 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471854009517 active site 471854009518 motif I; other site 471854009519 motif II; other site 471854009520 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471854009521 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 471854009522 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 471854009523 putative active site [active] 471854009524 putative metal binding site [ion binding]; other site 471854009525 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 471854009526 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 471854009527 active site 471854009528 metal binding site [ion binding]; metal-binding site 471854009529 DNA binding site [nucleotide binding] 471854009530 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 471854009531 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 471854009532 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 471854009533 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471854009534 alpha subunit interface [polypeptide binding]; other site 471854009535 TPP binding site [chemical binding]; other site 471854009536 heterodimer interface [polypeptide binding]; other site 471854009537 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471854009538 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 471854009539 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 471854009540 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 471854009541 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 471854009542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 471854009543 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 471854009544 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 471854009545 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 471854009546 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 471854009547 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 471854009548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 471854009549 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 471854009550 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 471854009551 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 471854009552 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471854009553 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 471854009554 active site 471854009555 catalytic triad [active] 471854009556 oxyanion hole [active] 471854009557 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 471854009558 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 471854009559 Mg++ binding site [ion binding]; other site 471854009560 putative catalytic motif [active] 471854009561 putative substrate binding site [chemical binding]; other site 471854009562 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 471854009563 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471854009564 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471854009565 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471854009566 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471854009567 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471854009568 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471854009569 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 471854009570 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 471854009571 MraW methylase family; Region: Methyltransf_5; cl17771 471854009572 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471854009573 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471854009574 catalytic residues [active] 471854009575 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471854009576 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 471854009577 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 471854009578 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471854009579 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471854009580 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471854009581 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 471854009582 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471854009583 substrate binding site [chemical binding]; other site 471854009584 oxyanion hole (OAH) forming residues; other site 471854009585 trimer interface [polypeptide binding]; other site 471854009586 Predicted transcriptional regulator [Transcription]; Region: COG1959 471854009587 Transcriptional regulator; Region: Rrf2; pfam02082 471854009588 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471854009589 active site 471854009590 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471854009591 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 471854009592 NAD binding site [chemical binding]; other site 471854009593 homotetramer interface [polypeptide binding]; other site 471854009594 homodimer interface [polypeptide binding]; other site 471854009595 active site 471854009596 substrate binding site [chemical binding]; other site 471854009597 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 471854009598 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 471854009599 active site 471854009600 Zn binding site [ion binding]; other site 471854009601 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 471854009602 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 471854009603 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471854009604 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471854009605 intersubunit interface [polypeptide binding]; other site 471854009606 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 471854009607 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471854009608 ABC-ATPase subunit interface; other site 471854009609 dimer interface [polypeptide binding]; other site 471854009610 putative PBP binding regions; other site 471854009611 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 471854009612 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471854009613 Walker A/P-loop; other site 471854009614 ATP binding site [chemical binding]; other site 471854009615 Q-loop/lid; other site 471854009616 ABC transporter signature motif; other site 471854009617 Walker B; other site 471854009618 D-loop; other site 471854009619 H-loop/switch region; other site 471854009620 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 471854009621 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 471854009622 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 471854009623 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 471854009624 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 471854009625 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 471854009626 active site 471854009627 dimer interface [polypeptide binding]; other site 471854009628 effector binding site; other site 471854009629 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 471854009630 adenylosuccinate lyase; Provisional; Region: PRK09285 471854009631 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 471854009632 tetramer interface [polypeptide binding]; other site 471854009633 active site 471854009634 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 471854009635 amphipathic channel; other site 471854009636 Asn-Pro-Ala signature motifs; other site 471854009637 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 471854009638 MG2 domain; Region: A2M_N; pfam01835 471854009639 Alpha-2-macroglobulin family; Region: A2M; pfam00207 471854009640 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 471854009641 surface patch; other site 471854009642 thioester region; other site 471854009643 specificity defining residues; other site 471854009644 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 471854009645 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 471854009646 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854009647 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854009648 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854009649 DNA binding residues [nucleotide binding] 471854009650 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 471854009651 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 471854009652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 471854009653 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471854009654 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471854009655 active site 471854009656 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 471854009657 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 471854009658 Cadherin repeat-like domain; Region: CA_like; cl15786 471854009659 Ca2+ binding site [ion binding]; other site 471854009660 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 471854009661 Cadherin repeat-like domain; Region: CA_like; cl15786 471854009662 Ca2+ binding site [ion binding]; other site 471854009663 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 471854009664 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854009665 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854009666 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471854009667 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471854009668 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471854009669 active site 471854009670 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471854009671 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 471854009672 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471854009673 dimer interface [polypeptide binding]; other site 471854009674 active site 471854009675 PspC domain; Region: PspC; pfam04024 471854009676 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 471854009677 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 471854009678 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854009679 nucleotide binding region [chemical binding]; other site 471854009680 ATP-binding site [chemical binding]; other site 471854009681 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 471854009682 Rhomboid family; Region: Rhomboid; pfam01694 471854009683 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 471854009684 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471854009685 substrate binding pocket [chemical binding]; other site 471854009686 chain length determination region; other site 471854009687 substrate-Mg2+ binding site; other site 471854009688 catalytic residues [active] 471854009689 aspartate-rich region 1; other site 471854009690 active site lid residues [active] 471854009691 aspartate-rich region 2; other site 471854009692 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 471854009693 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 471854009694 homodimer interface [polypeptide binding]; other site 471854009695 substrate-cofactor binding pocket; other site 471854009696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854009697 catalytic residue [active] 471854009698 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 471854009699 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 471854009700 thiamine-monophosphate kinase; Region: thiL; TIGR01379 471854009701 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 471854009702 ATP binding site [chemical binding]; other site 471854009703 dimerization interface [polypeptide binding]; other site 471854009704 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 471854009705 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 471854009706 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 471854009707 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854009708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854009709 dimer interface [polypeptide binding]; other site 471854009710 phosphorylation site [posttranslational modification] 471854009711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854009712 ATP binding site [chemical binding]; other site 471854009713 Mg2+ binding site [ion binding]; other site 471854009714 G-X-G motif; other site 471854009715 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471854009716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854009717 active site 471854009718 phosphorylation site [posttranslational modification] 471854009719 intermolecular recognition site; other site 471854009720 dimerization interface [polypeptide binding]; other site 471854009721 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471854009722 DNA binding site [nucleotide binding] 471854009723 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 471854009724 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 471854009725 catalytic center binding site [active] 471854009726 ATP binding site [chemical binding]; other site 471854009727 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854009728 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854009729 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854009730 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 471854009731 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 471854009732 homodimer interface [polypeptide binding]; other site 471854009733 homotetramer interface [polypeptide binding]; other site 471854009734 active site pocket [active] 471854009735 cleavage site 471854009736 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854009737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854009738 DNA binding residues [nucleotide binding] 471854009739 dimerization interface [polypeptide binding]; other site 471854009740 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 471854009741 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 471854009742 Clp amino terminal domain; Region: Clp_N; pfam02861 471854009743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854009744 Walker A motif; other site 471854009745 ATP binding site [chemical binding]; other site 471854009746 Walker B motif; other site 471854009747 arginine finger; other site 471854009748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854009749 Walker A motif; other site 471854009750 ATP binding site [chemical binding]; other site 471854009751 Walker B motif; other site 471854009752 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 471854009753 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 471854009754 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 471854009755 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471854009756 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 471854009757 ligand binding site [chemical binding]; other site 471854009758 PAAR motif; Region: PAAR_motif; cl15808 471854009759 Protein of unknown function (DUF877); Region: DUF877; pfam05943 471854009760 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 471854009761 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 471854009762 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 471854009763 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 471854009764 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 471854009765 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 471854009766 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 471854009767 Protein export membrane protein; Region: SecD_SecF; pfam02355 471854009768 amino acid transporter; Region: 2A0306; TIGR00909 471854009769 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 471854009770 Predicted dehydrogenase [General function prediction only]; Region: COG0579 471854009771 hydroxyglutarate oxidase; Provisional; Region: PRK11728 471854009772 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 471854009773 PSP1 C-terminal conserved region; Region: PSP1; cl00770 471854009774 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 471854009775 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 471854009776 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 471854009777 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 471854009778 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 471854009779 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471854009780 ATP binding site [chemical binding]; other site 471854009781 putative Mg++ binding site [ion binding]; other site 471854009782 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854009783 nucleotide binding region [chemical binding]; other site 471854009784 ATP-binding site [chemical binding]; other site 471854009785 RQC domain; Region: RQC; pfam09382 471854009786 HRDC domain; Region: HRDC; pfam00570 471854009787 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 471854009788 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 471854009789 putative active site [active] 471854009790 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 471854009791 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 471854009792 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 471854009793 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471854009794 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471854009795 FeS/SAM binding site; other site 471854009796 TRAM domain; Region: TRAM; cl01282 471854009797 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 471854009798 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 471854009799 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 471854009800 GTP binding site [chemical binding]; other site 471854009801 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 471854009802 ribosomal protein L33; Region: rpl33; CHL00104 471854009803 Cytochrome c; Region: Cytochrom_C; cl11414 471854009804 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 471854009805 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 471854009806 GatB domain; Region: GatB_Yqey; smart00845 471854009807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854009808 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471854009809 NAD(P) binding site [chemical binding]; other site 471854009810 active site 471854009811 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 471854009812 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 471854009813 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 471854009814 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854009815 FtsX-like permease family; Region: FtsX; pfam02687 471854009816 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471854009817 Walker A/P-loop; other site 471854009818 ATP binding site [chemical binding]; other site 471854009819 ABC transporter; Region: ABC_tran; pfam00005 471854009820 Q-loop/lid; other site 471854009821 ABC transporter signature motif; other site 471854009822 Walker B; other site 471854009823 D-loop; other site 471854009824 H-loop/switch region; other site 471854009825 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 471854009826 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 471854009827 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 471854009828 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 471854009829 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471854009830 motif II; other site 471854009831 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 471854009832 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854009833 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854009834 DNA binding residues [nucleotide binding] 471854009835 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 471854009836 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471854009837 minor groove reading motif; other site 471854009838 helix-hairpin-helix signature motif; other site 471854009839 substrate binding pocket [chemical binding]; other site 471854009840 active site 471854009841 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 471854009842 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471854009843 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471854009844 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 471854009845 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471854009846 inhibitor-cofactor binding pocket; inhibition site 471854009847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854009848 catalytic residue [active] 471854009849 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 471854009850 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 471854009851 putative trimer interface [polypeptide binding]; other site 471854009852 putative CoA binding site [chemical binding]; other site 471854009853 Bacterial sugar transferase; Region: Bac_transf; pfam02397 471854009854 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471854009855 tetramer interface [polypeptide binding]; other site 471854009856 TPP-binding site [chemical binding]; other site 471854009857 heterodimer interface [polypeptide binding]; other site 471854009858 phosphorylation loop region [posttranslational modification] 471854009859 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 471854009860 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471854009861 PYR/PP interface [polypeptide binding]; other site 471854009862 dimer interface [polypeptide binding]; other site 471854009863 TPP binding site [chemical binding]; other site 471854009864 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471854009865 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 471854009866 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 471854009867 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 471854009868 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 471854009869 active site 471854009870 metal binding site [ion binding]; metal-binding site 471854009871 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 471854009872 mce related protein; Region: MCE; pfam02470 471854009873 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 471854009874 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 471854009875 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 471854009876 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 471854009877 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 471854009878 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 471854009879 active site 471854009880 dimer interface [polypeptide binding]; other site 471854009881 metal binding site [ion binding]; metal-binding site 471854009882 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471854009883 active site 471854009884 metal binding site [ion binding]; metal-binding site 471854009885 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854009886 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471854009887 active site 471854009888 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471854009889 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 471854009890 putative acyl-acceptor binding pocket; other site 471854009891 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 471854009892 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471854009893 active site 471854009894 motif I; other site 471854009895 motif II; other site 471854009896 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471854009897 motif II; other site 471854009898 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 471854009899 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 471854009900 active site 471854009901 metal binding site [ion binding]; metal-binding site 471854009902 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 471854009903 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 471854009904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854009905 Walker A motif; other site 471854009906 ATP binding site [chemical binding]; other site 471854009907 Walker B motif; other site 471854009908 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 471854009909 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471854009910 putative active site [active] 471854009911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854009912 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 471854009913 NAD(P) binding site [chemical binding]; other site 471854009914 active site 471854009915 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471854009916 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854009917 Esterase/lipase [General function prediction only]; Region: COG1647 471854009918 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471854009919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854009920 active site 471854009921 phosphorylation site [posttranslational modification] 471854009922 intermolecular recognition site; other site 471854009923 dimerization interface [polypeptide binding]; other site 471854009924 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471854009925 DNA binding site [nucleotide binding] 471854009926 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 471854009927 dimer interface [polypeptide binding]; other site 471854009928 allosteric magnesium binding site [ion binding]; other site 471854009929 active site 471854009930 aspartate-rich active site metal binding site; other site 471854009931 Schiff base residues; other site 471854009932 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471854009933 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 471854009934 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471854009935 Peptidase family M28; Region: Peptidase_M28; pfam04389 471854009936 metal binding site [ion binding]; metal-binding site 471854009937 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 471854009938 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854009939 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471854009940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 471854009941 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 471854009942 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 471854009943 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 471854009944 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 471854009945 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471854009946 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 471854009947 putative active site [active] 471854009948 putative metal binding site [ion binding]; other site 471854009949 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 471854009950 LVIVD repeat; Region: LVIVD; pfam08309 471854009951 LVIVD repeat; Region: LVIVD; pfam08309 471854009952 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 471854009953 serpin-like protein; Provisional; Region: PHA02660 471854009954 reactive center loop; other site 471854009955 Anti-sigma-K factor rskA; Region: RskA; pfam10099 471854009956 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 471854009957 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 471854009958 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854009959 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854009960 DNA binding residues [nucleotide binding] 471854009961 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 471854009962 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471854009963 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 471854009964 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471854009965 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 471854009966 putative active site [active] 471854009967 putative substrate binding site [chemical binding]; other site 471854009968 putative cosubstrate binding site; other site 471854009969 catalytic site [active] 471854009970 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 471854009971 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 471854009972 active site 471854009973 catalytic residues [active] 471854009974 metal binding site [ion binding]; metal-binding site 471854009975 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 471854009976 tartrate dehydrogenase; Region: TTC; TIGR02089 471854009977 (R)-citramalate synthase; Provisional; Region: PRK09389 471854009978 Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945 471854009979 active site 471854009980 catalytic residues [active] 471854009981 metal binding site [ion binding]; metal-binding site 471854009982 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 471854009983 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 471854009984 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 471854009985 substrate binding site [chemical binding]; other site 471854009986 NapD protein; Region: NapD; cl01163 471854009987 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 471854009988 four helix bundle protein; Region: TIGR02436 471854009989 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 471854009990 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 471854009991 substrate binding site [chemical binding]; other site 471854009992 ligand binding site [chemical binding]; other site 471854009993 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471854009994 active site 471854009995 NTP binding site [chemical binding]; other site 471854009996 metal binding triad [ion binding]; metal-binding site 471854009997 antibiotic binding site [chemical binding]; other site 471854009998 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 471854009999 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854010000 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854010001 threonine dehydratase; Validated; Region: PRK08639 471854010002 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471854010003 tetramer interface [polypeptide binding]; other site 471854010004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854010005 catalytic residue [active] 471854010006 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 471854010007 putative Ile/Val binding site [chemical binding]; other site 471854010008 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 471854010009 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 471854010010 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 471854010011 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 471854010012 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 471854010013 putative valine binding site [chemical binding]; other site 471854010014 dimer interface [polypeptide binding]; other site 471854010015 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 471854010016 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 471854010017 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471854010018 PYR/PP interface [polypeptide binding]; other site 471854010019 dimer interface [polypeptide binding]; other site 471854010020 TPP binding site [chemical binding]; other site 471854010021 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471854010022 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 471854010023 TPP-binding site [chemical binding]; other site 471854010024 dimer interface [polypeptide binding]; other site 471854010025 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 471854010026 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 471854010027 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 471854010028 putative active site [active] 471854010029 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 471854010030 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471854010031 NAD(P) binding site [chemical binding]; other site 471854010032 NIPSNAP; Region: NIPSNAP; pfam07978 471854010033 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 471854010034 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 471854010035 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 471854010036 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 471854010037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854010038 Walker A motif; other site 471854010039 ATP binding site [chemical binding]; other site 471854010040 Walker B motif; other site 471854010041 arginine finger; other site 471854010042 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 471854010043 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 471854010044 active site 471854010045 8-oxo-dGMP binding site [chemical binding]; other site 471854010046 nudix motif; other site 471854010047 metal binding site [ion binding]; metal-binding site 471854010048 dihydroorotase; Reviewed; Region: PRK09236 471854010049 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854010050 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 471854010051 active site 471854010052 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 471854010053 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471854010054 active site 471854010055 gliding motility-associated lipoprotein GldJ; Region: GldJ_short; TIGR03530 471854010056 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 471854010057 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 471854010058 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 471854010059 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 471854010060 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 471854010061 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471854010062 ATP binding site [chemical binding]; other site 471854010063 putative Mg++ binding site [ion binding]; other site 471854010064 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854010065 nucleotide binding region [chemical binding]; other site 471854010066 ATP-binding site [chemical binding]; other site 471854010067 TRCF domain; Region: TRCF; pfam03461 471854010068 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 471854010069 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 471854010070 RNAase interaction site [polypeptide binding]; other site 471854010071 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854010072 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 471854010073 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 471854010074 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 471854010075 Substrate binding site [chemical binding]; other site 471854010076 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 471854010077 Domain of unknown function (DUF718); Region: DUF718; pfam05336 471854010078 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 471854010079 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 471854010080 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 471854010081 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 471854010082 ligand binding site [chemical binding]; other site 471854010083 metal binding site [ion binding]; metal-binding site 471854010084 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 471854010085 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854010086 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854010087 SusD family; Region: SusD; pfam07980 471854010088 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854010089 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854010090 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854010091 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854010092 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854010093 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854010094 FecR protein; Region: FecR; pfam04773 471854010095 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854010096 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854010097 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471854010098 DNA binding residues [nucleotide binding] 471854010099 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 471854010100 HEAT repeats; Region: HEAT_2; pfam13646 471854010101 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 471854010102 Cytochrome c; Region: Cytochrom_C; pfam00034 471854010103 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471854010104 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471854010105 Metal-binding active site; metal-binding site 471854010106 AP (apurinic/apyrimidinic) site pocket; other site 471854010107 hypothetical protein; Reviewed; Region: PRK12497 471854010108 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 471854010109 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 471854010110 active site 471854010111 catalytic site [active] 471854010112 substrate binding site [chemical binding]; other site 471854010113 ribonuclease R; Region: RNase_R; TIGR02063 471854010114 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471854010115 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471854010116 RNB domain; Region: RNB; pfam00773 471854010117 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 471854010118 RNA binding site [nucleotide binding]; other site 471854010119 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854010120 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 471854010121 DNA polymerase III subunit beta; Validated; Region: PRK05643 471854010122 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 471854010123 putative DNA binding surface [nucleotide binding]; other site 471854010124 dimer interface [polypeptide binding]; other site 471854010125 beta-clamp/clamp loader binding surface; other site 471854010126 beta-clamp/translesion DNA polymerase binding surface; other site 471854010127 Penicillinase repressor; Region: Pencillinase_R; pfam03965 471854010128 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 471854010129 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 471854010130 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 471854010131 FAD binding pocket [chemical binding]; other site 471854010132 FAD binding motif [chemical binding]; other site 471854010133 phosphate binding motif [ion binding]; other site 471854010134 beta-alpha-beta structure motif; other site 471854010135 NAD(p) ribose binding residues [chemical binding]; other site 471854010136 NAD binding pocket [chemical binding]; other site 471854010137 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 471854010138 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471854010139 catalytic loop [active] 471854010140 iron binding site [ion binding]; other site 471854010141 aspartate aminotransferase; Provisional; Region: PRK05764 471854010142 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471854010143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854010144 homodimer interface [polypeptide binding]; other site 471854010145 catalytic residue [active] 471854010146 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 471854010147 hypothetical protein; Reviewed; Region: PRK09588 471854010148 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 471854010149 putative hydrophobic ligand binding site [chemical binding]; other site 471854010150 hypothetical protein; Provisional; Region: PHA02962 471854010151 Surface antigen; Region: Bac_surface_Ag; pfam01103 471854010152 isocitrate dehydrogenase; Validated; Region: PRK08299 471854010153 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 471854010154 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 471854010155 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 471854010156 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 471854010157 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 471854010158 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 471854010159 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 471854010160 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471854010161 Glycogen synthase; Region: Glycogen_syn; pfam05693 471854010162 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 471854010163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854010164 Walker A motif; other site 471854010165 ATP binding site [chemical binding]; other site 471854010166 Walker B motif; other site 471854010167 arginine finger; other site 471854010168 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 471854010169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854010170 S-adenosylmethionine binding site [chemical binding]; other site 471854010171 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 471854010172 hypothetical protein; Provisional; Region: PRK08201 471854010173 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 471854010174 metal binding site [ion binding]; metal-binding site 471854010175 putative dimer interface [polypeptide binding]; other site 471854010176 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854010177 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471854010178 active site 471854010179 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 471854010180 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471854010181 Beta-Casp domain; Region: Beta-Casp; smart01027 471854010182 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 471854010183 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 471854010184 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 471854010185 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 471854010186 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854010187 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471854010188 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471854010189 ligand binding site [chemical binding]; other site 471854010190 flexible hinge region; other site 471854010191 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 471854010192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854010193 Walker A/P-loop; other site 471854010194 ATP binding site [chemical binding]; other site 471854010195 Q-loop/lid; other site 471854010196 ABC transporter signature motif; other site 471854010197 Walker B; other site 471854010198 D-loop; other site 471854010199 H-loop/switch region; other site 471854010200 Penicillinase repressor; Region: Pencillinase_R; pfam03965 471854010201 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 471854010202 methionine sulfoxide reductase A; Provisional; Region: PRK14054 471854010203 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 471854010204 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 471854010205 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 471854010206 active site 471854010207 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471854010208 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471854010209 Walker A/P-loop; other site 471854010210 ATP binding site [chemical binding]; other site 471854010211 Q-loop/lid; other site 471854010212 ABC transporter signature motif; other site 471854010213 Walker B; other site 471854010214 D-loop; other site 471854010215 H-loop/switch region; other site 471854010216 TPR repeat; Region: TPR_11; pfam13414 471854010217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854010218 binding surface 471854010219 TPR motif; other site 471854010220 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854010221 binding surface 471854010222 TPR motif; other site 471854010223 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 471854010224 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471854010225 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 471854010226 alpha subunit interaction interface [polypeptide binding]; other site 471854010227 Walker A motif; other site 471854010228 ATP binding site [chemical binding]; other site 471854010229 Walker B motif; other site 471854010230 inhibitor binding site; inhibition site 471854010231 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471854010232 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 471854010233 gamma subunit interface [polypeptide binding]; other site 471854010234 LBP interface [polypeptide binding]; other site 471854010235 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 471854010236 putative active site [active] 471854010237 PIN domain; Region: PIN_3; cl17397 471854010238 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 471854010239 putative active site [active] 471854010240 Amino acid permease; Region: AA_permease_2; pfam13520 471854010241 MG2 domain; Region: A2M_N; pfam01835 471854010242 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854010243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854010244 TPR motif; other site 471854010245 binding surface 471854010246 TPR repeat; Region: TPR_11; pfam13414 471854010247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854010248 binding surface 471854010249 TPR motif; other site 471854010250 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854010251 binding surface 471854010252 TPR motif; other site 471854010253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854010254 TPR motif; other site 471854010255 binding surface 471854010256 TPR repeat; Region: TPR_11; pfam13414 471854010257 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854010258 binding surface 471854010259 TPR motif; other site 471854010260 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 471854010261 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 471854010262 Peptidase family M23; Region: Peptidase_M23; pfam01551 471854010263 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 471854010264 active site 471854010265 oligomerization interface [polypeptide binding]; other site 471854010266 metal binding site [ion binding]; metal-binding site 471854010267 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 471854010268 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 471854010269 active site 471854010270 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 471854010271 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 471854010272 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471854010273 ATP binding site [chemical binding]; other site 471854010274 putative Mg++ binding site [ion binding]; other site 471854010275 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854010276 nucleotide binding region [chemical binding]; other site 471854010277 ATP-binding site [chemical binding]; other site 471854010278 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 471854010279 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 471854010280 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 471854010281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 471854010282 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 471854010283 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 471854010284 NADP binding site [chemical binding]; other site 471854010285 active site 471854010286 putative substrate binding site [chemical binding]; other site 471854010287 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471854010288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471854010289 putative DNA binding site [nucleotide binding]; other site 471854010290 putative Zn2+ binding site [ion binding]; other site 471854010291 AsnC family; Region: AsnC_trans_reg; pfam01037 471854010292 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 471854010293 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 471854010294 Part of AAA domain; Region: AAA_19; pfam13245 471854010295 Family description; Region: UvrD_C_2; pfam13538 471854010296 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 471854010297 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 471854010298 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 471854010299 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 471854010300 Glutamine amidotransferase class-I; Region: GATase; pfam00117 471854010301 glutamine binding [chemical binding]; other site 471854010302 catalytic triad [active] 471854010303 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 471854010304 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 471854010305 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 471854010306 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 471854010307 active site 471854010308 ribulose/triose binding site [chemical binding]; other site 471854010309 phosphate binding site [ion binding]; other site 471854010310 substrate (anthranilate) binding pocket [chemical binding]; other site 471854010311 product (indole) binding pocket [chemical binding]; other site 471854010312 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 471854010313 active site 471854010314 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 471854010315 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 471854010316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854010317 catalytic residue [active] 471854010318 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 471854010319 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 471854010320 substrate binding site [chemical binding]; other site 471854010321 active site 471854010322 catalytic residues [active] 471854010323 heterodimer interface [polypeptide binding]; other site 471854010324 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 471854010325 phosphodiesterase; Provisional; Region: PRK12704 471854010326 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 471854010327 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 471854010328 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 471854010329 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 471854010330 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 471854010331 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471854010332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854010333 S-adenosylmethionine binding site [chemical binding]; other site 471854010334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 471854010335 Bacterial Ig-like domain; Region: Big_5; pfam13205 471854010336 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 471854010337 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 471854010338 Tetratricopeptide repeat; Region: TPR_6; pfam13174 471854010339 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 471854010340 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 471854010341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854010342 catalytic residue [active] 471854010343 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 471854010344 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 471854010345 Glutamate binding site [chemical binding]; other site 471854010346 NAD binding site [chemical binding]; other site 471854010347 catalytic residues [active] 471854010348 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 471854010349 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 471854010350 TPP-binding site; other site 471854010351 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471854010352 PYR/PP interface [polypeptide binding]; other site 471854010353 dimer interface [polypeptide binding]; other site 471854010354 TPP binding site [chemical binding]; other site 471854010355 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471854010356 Rhomboid family; Region: Rhomboid; cl11446 471854010357 Rhomboid family; Region: Rhomboid; pfam01694 471854010358 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 471854010359 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 471854010360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854010361 ATP binding site [chemical binding]; other site 471854010362 Mg2+ binding site [ion binding]; other site 471854010363 G-X-G motif; other site 471854010364 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 471854010365 ATP binding site [chemical binding]; other site 471854010366 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 471854010367 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 471854010368 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 471854010369 active site 471854010370 trimer interface [polypeptide binding]; other site 471854010371 allosteric site; other site 471854010372 active site lid [active] 471854010373 hexamer (dimer of trimers) interface [polypeptide binding]; other site 471854010374 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 471854010375 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 471854010376 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 471854010377 dimer interface [polypeptide binding]; other site 471854010378 active site 471854010379 glycine-pyridoxal phosphate binding site [chemical binding]; other site 471854010380 folate binding site [chemical binding]; other site 471854010381 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 471854010382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 471854010383 TPR motif; other site 471854010384 binding surface 471854010385 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 471854010386 homopentamer interface [polypeptide binding]; other site 471854010387 active site 471854010388 aspartate kinase III; Validated; Region: PRK09084 471854010389 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 471854010390 nucleotide binding site [chemical binding]; other site 471854010391 substrate binding site [chemical binding]; other site 471854010392 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 471854010393 dimer interface [polypeptide binding]; other site 471854010394 allosteric regulatory binding pocket; other site 471854010395 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471854010396 seryl-tRNA synthetase; Provisional; Region: PRK05431 471854010397 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 471854010398 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471854010399 motif 1; other site 471854010400 dimer interface [polypeptide binding]; other site 471854010401 active site 471854010402 motif 2; other site 471854010403 motif 3; other site 471854010404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854010405 Walker A/P-loop; other site 471854010406 ATP binding site [chemical binding]; other site 471854010407 Q-loop/lid; other site 471854010408 ABC transporter signature motif; other site 471854010409 Walker B; other site 471854010410 D-loop; other site 471854010411 H-loop/switch region; other site 471854010412 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471854010413 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 471854010414 FAD binding site [chemical binding]; other site 471854010415 homotetramer interface [polypeptide binding]; other site 471854010416 substrate binding pocket [chemical binding]; other site 471854010417 catalytic base [active] 471854010418 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854010419 SnoaL-like domain; Region: SnoaL_3; pfam13474 471854010420 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 471854010421 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 471854010422 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 471854010423 active site 471854010424 (T/H)XGH motif; other site 471854010425 Guanylate kinase; Region: Guanylate_kin; pfam00625 471854010426 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 471854010427 catalytic site [active] 471854010428 G-X2-G-X-G-K; other site 471854010429 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 471854010430 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 471854010431 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854010432 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854010433 DNA binding residues [nucleotide binding] 471854010434 rod shape-determining protein MreC; Provisional; Region: PRK13922 471854010435 rod shape-determining protein MreC; Region: MreC; pfam04085 471854010436 rod shape-determining protein MreB; Provisional; Region: PRK13927 471854010437 MreB and similar proteins; Region: MreB_like; cd10225 471854010438 nucleotide binding site [chemical binding]; other site 471854010439 Mg binding site [ion binding]; other site 471854010440 putative protofilament interaction site [polypeptide binding]; other site 471854010441 RodZ interaction site [polypeptide binding]; other site 471854010442 GH3 auxin-responsive promoter; Region: GH3; pfam03321 471854010443 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 471854010444 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 471854010445 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 471854010446 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 471854010447 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 471854010448 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 471854010449 Ligand binding site; other site 471854010450 Putative Catalytic site; other site 471854010451 DXD motif; other site 471854010452 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854010453 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471854010454 active site 471854010455 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 471854010456 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 471854010457 active site 471854010458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854010459 S-adenosylmethionine binding site [chemical binding]; other site 471854010460 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471854010461 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 471854010462 metal binding site [ion binding]; metal-binding site 471854010463 dimer interface [polypeptide binding]; other site 471854010464 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471854010465 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 471854010466 Ligand binding site; other site 471854010467 Putative Catalytic site; other site 471854010468 DXD motif; other site 471854010469 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 471854010470 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471854010471 Protein of unknown function DUF58; Region: DUF58; pfam01882 471854010472 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 471854010473 metal ion-dependent adhesion site (MIDAS); other site 471854010474 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471854010475 metal ion-dependent adhesion site (MIDAS); other site 471854010476 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 471854010477 RNA/DNA hybrid binding site [nucleotide binding]; other site 471854010478 active site 471854010479 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 471854010480 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 471854010481 Glycoprotease family; Region: Peptidase_M22; pfam00814 471854010482 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 471854010483 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 471854010484 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 471854010485 protein binding site [polypeptide binding]; other site 471854010486 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 471854010487 Catalytic dyad [active] 471854010488 ribonuclease P; Reviewed; Region: rnpA; PRK01903 471854010489 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 471854010490 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 471854010491 Sulfatase; Region: Sulfatase; pfam00884 471854010492 GTPase Era; Reviewed; Region: era; PRK00089 471854010493 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 471854010494 G1 box; other site 471854010495 GTP/Mg2+ binding site [chemical binding]; other site 471854010496 Switch I region; other site 471854010497 G2 box; other site 471854010498 Switch II region; other site 471854010499 G3 box; other site 471854010500 G4 box; other site 471854010501 G5 box; other site 471854010502 KH domain; Region: KH_2; pfam07650 471854010503 GTP-binding protein Der; Reviewed; Region: PRK00093 471854010504 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 471854010505 G1 box; other site 471854010506 GTP/Mg2+ binding site [chemical binding]; other site 471854010507 Switch I region; other site 471854010508 G2 box; other site 471854010509 Switch II region; other site 471854010510 G3 box; other site 471854010511 G4 box; other site 471854010512 G5 box; other site 471854010513 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 471854010514 G1 box; other site 471854010515 GTP/Mg2+ binding site [chemical binding]; other site 471854010516 Switch I region; other site 471854010517 G2 box; other site 471854010518 G3 box; other site 471854010519 Switch II region; other site 471854010520 G4 box; other site 471854010521 G5 box; other site 471854010522 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 471854010523 RES domain; Region: RES; pfam08808 471854010524 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 471854010525 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 471854010526 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 471854010527 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471854010528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854010529 ABC transporter signature motif; other site 471854010530 Walker B; other site 471854010531 D-loop; other site 471854010532 H-loop/switch region; other site 471854010533 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 471854010534 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 471854010535 catalytic triad [active] 471854010536 conserved cis-peptide bond; other site 471854010537 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854010538 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 471854010539 Probable Catalytic site; other site 471854010540 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 471854010541 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471854010542 ligand binding site [chemical binding]; other site 471854010543 triosephosphate isomerase; Provisional; Region: PRK14567 471854010544 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 471854010545 substrate binding site [chemical binding]; other site 471854010546 dimer interface [polypeptide binding]; other site 471854010547 catalytic triad [active] 471854010548 Aspartyl protease; Region: Asp_protease_2; pfam13650 471854010549 inhibitor binding site; inhibition site 471854010550 catalytic motif [active] 471854010551 Catalytic residue [active] 471854010552 Active site flap [active] 471854010553 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 471854010554 catalytic motif [active] 471854010555 Catalytic residue [active] 471854010556 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 471854010557 protein binding site [polypeptide binding]; other site 471854010558 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 471854010559 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 471854010560 dimer interface [polypeptide binding]; other site 471854010561 active site 471854010562 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 471854010563 nudix motif; other site 471854010564 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 471854010565 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471854010566 ATP binding site [chemical binding]; other site 471854010567 putative Mg++ binding site [ion binding]; other site 471854010568 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854010569 nucleotide binding region [chemical binding]; other site 471854010570 ATP-binding site [chemical binding]; other site 471854010571 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 471854010572 homotrimer interaction site [polypeptide binding]; other site 471854010573 putative active site [active] 471854010574 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 471854010575 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471854010576 ATP binding site [chemical binding]; other site 471854010577 putative Mg++ binding site [ion binding]; other site 471854010578 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854010579 nucleotide binding region [chemical binding]; other site 471854010580 ATP-binding site [chemical binding]; other site 471854010581 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 471854010582 HRDC domain; Region: HRDC; pfam00570 471854010583 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 471854010584 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 471854010585 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 471854010586 dimerization interface [polypeptide binding]; other site 471854010587 active site 471854010588 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 471854010589 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471854010590 active site 471854010591 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854010592 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854010593 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854010594 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854010595 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 471854010596 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 471854010597 Substrate binding site; other site 471854010598 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 471854010599 recombination protein F; Reviewed; Region: recF; PRK00064 471854010600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854010601 Walker A/P-loop; other site 471854010602 ATP binding site [chemical binding]; other site 471854010603 Q-loop/lid; other site 471854010604 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854010605 ABC transporter signature motif; other site 471854010606 Walker B; other site 471854010607 D-loop; other site 471854010608 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 471854010609 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471854010610 tetramer interface [polypeptide binding]; other site 471854010611 TPP-binding site [chemical binding]; other site 471854010612 heterodimer interface [polypeptide binding]; other site 471854010613 phosphorylation loop region [posttranslational modification] 471854010614 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 471854010615 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471854010616 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 471854010617 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471854010618 catalytic residue [active] 471854010619 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 471854010620 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 471854010621 active site 471854010622 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01911 471854010623 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 471854010624 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 471854010625 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471854010626 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 471854010627 Dienelactone hydrolase family; Region: DLH; pfam01738 471854010628 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854010629 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 471854010630 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 471854010631 NAD(P) binding site [chemical binding]; other site 471854010632 homodimer interface [polypeptide binding]; other site 471854010633 substrate binding site [chemical binding]; other site 471854010634 active site 471854010635 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 471854010636 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471854010637 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 471854010638 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471854010639 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 471854010640 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 471854010641 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471854010642 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 471854010643 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471854010644 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 471854010645 active site 471854010646 catalytic site [active] 471854010647 substrate binding site [chemical binding]; other site 471854010648 glycerol kinase; Provisional; Region: glpK; PRK00047 471854010649 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 471854010650 N- and C-terminal domain interface [polypeptide binding]; other site 471854010651 active site 471854010652 MgATP binding site [chemical binding]; other site 471854010653 catalytic site [active] 471854010654 metal binding site [ion binding]; metal-binding site 471854010655 putative homotetramer interface [polypeptide binding]; other site 471854010656 glycerol binding site [chemical binding]; other site 471854010657 homodimer interface [polypeptide binding]; other site 471854010658 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 471854010659 Transglycosylase; Region: Transgly; pfam00912 471854010660 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 471854010661 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 471854010662 M28 Zn-Peptidases; Region: M28_like_6; cd08656 471854010663 Peptidase family M28; Region: Peptidase_M28; pfam04389 471854010664 metal binding site [ion binding]; metal-binding site 471854010665 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 471854010666 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 471854010667 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471854010668 active site 471854010669 HIGH motif; other site 471854010670 nucleotide binding site [chemical binding]; other site 471854010671 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471854010672 KMSKS motif; other site 471854010673 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471854010674 tRNA binding surface [nucleotide binding]; other site 471854010675 anticodon binding site; other site 471854010676 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 471854010677 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471854010678 substrate binding site [chemical binding]; other site 471854010679 ATP binding site [chemical binding]; other site 471854010680 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471854010681 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 471854010682 putative active site [active] 471854010683 catalytic site [active] 471854010684 putative metal binding site [ion binding]; other site 471854010685 oligomer interface [polypeptide binding]; other site 471854010686 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 471854010687 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 471854010688 active site 471854010689 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 471854010690 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 471854010691 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 471854010692 acyl carrier protein; Provisional; Region: acpP; PRK00982 471854010693 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471854010694 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471854010695 dimer interface [polypeptide binding]; other site 471854010696 active site 471854010697 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 471854010698 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 471854010699 dimerization interface [polypeptide binding]; other site 471854010700 active site 471854010701 metal binding site [ion binding]; metal-binding site 471854010702 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 471854010703 dsRNA binding site [nucleotide binding]; other site 471854010704 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 471854010705 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 471854010706 putative dimer interface [polypeptide binding]; other site 471854010707 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 471854010708 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 471854010709 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471854010710 protein binding site [polypeptide binding]; other site 471854010711 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471854010712 protein binding site [polypeptide binding]; other site 471854010713 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 471854010714 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471854010715 RNA binding surface [nucleotide binding]; other site 471854010716 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 471854010717 active site 471854010718 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 471854010719 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 471854010720 acyl-activating enzyme (AAE) consensus motif; other site 471854010721 putative AMP binding site [chemical binding]; other site 471854010722 putative active site [active] 471854010723 putative CoA binding site [chemical binding]; other site 471854010724 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 471854010725 C-terminal peptidase (prc); Region: prc; TIGR00225 471854010726 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 471854010727 protein binding site [polypeptide binding]; other site 471854010728 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 471854010729 Catalytic dyad [active] 471854010730 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 471854010731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854010732 NAD(P) binding site [chemical binding]; other site 471854010733 active site 471854010734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854010735 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471854010736 putative substrate translocation pore; other site 471854010737 Peptidase family M23; Region: Peptidase_M23; pfam01551 471854010738 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 471854010739 active site 471854010740 exopolyphosphatase; Region: exo_poly_only; TIGR03706 471854010741 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 471854010742 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 471854010743 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 471854010744 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471854010745 active site 471854010746 DNA binding site [nucleotide binding] 471854010747 Int/Topo IB signature motif; other site 471854010748 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 471854010749 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 471854010750 colanic acid exporter; Provisional; Region: PRK10459 471854010751 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 471854010752 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854010753 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471854010754 active site 471854010755 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471854010756 MarR family; Region: MarR_2; pfam12802 471854010757 MarR family; Region: MarR_2; cl17246 471854010758 Uncharacterized conserved protein [Function unknown]; Region: COG2968 471854010759 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 471854010760 YtxH-like protein; Region: YtxH; pfam12732 471854010761 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 471854010762 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 471854010763 dimer interface [polypeptide binding]; other site 471854010764 ADP-ribose binding site [chemical binding]; other site 471854010765 active site 471854010766 nudix motif; other site 471854010767 metal binding site [ion binding]; metal-binding site 471854010768 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 471854010769 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 471854010770 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 471854010771 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854010772 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471854010773 FtsX-like permease family; Region: FtsX; pfam02687 471854010774 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 471854010775 putative rRNA binding site [nucleotide binding]; other site 471854010776 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 471854010777 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471854010778 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 471854010779 SnoaL-like domain; Region: SnoaL_3; pfam13474 471854010780 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 471854010781 membrane ATPase/protein kinase; Provisional; Region: PRK09435 471854010782 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 471854010783 Walker A; other site 471854010784 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 471854010785 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 471854010786 Zn binding site [ion binding]; other site 471854010787 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 471854010788 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 471854010789 dimer interface [polypeptide binding]; other site 471854010790 active site 471854010791 CoA binding pocket [chemical binding]; other site 471854010792 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471854010793 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854010794 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 471854010795 intersubunit interface [polypeptide binding]; other site 471854010796 active site 471854010797 catalytic residue [active] 471854010798 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 471854010799 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 471854010800 G1 box; other site 471854010801 GTP/Mg2+ binding site [chemical binding]; other site 471854010802 Switch I region; other site 471854010803 G2 box; other site 471854010804 G3 box; other site 471854010805 Switch II region; other site 471854010806 G4 box; other site 471854010807 G5 box; other site 471854010808 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 471854010809 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471854010810 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 471854010811 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 471854010812 NADP-binding site; other site 471854010813 homotetramer interface [polypeptide binding]; other site 471854010814 substrate binding site [chemical binding]; other site 471854010815 homodimer interface [polypeptide binding]; other site 471854010816 active site 471854010817 Sporulation related domain; Region: SPOR; pfam05036 471854010818 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 471854010819 FAD binding domain; Region: FAD_binding_4; pfam01565 471854010820 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 471854010821 Domain of unknown function (DUF303); Region: DUF303; pfam03629 471854010822 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471854010823 Interdomain contacts; other site 471854010824 Cytokine receptor motif; other site 471854010825 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854010826 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 471854010827 Ligand binding site; other site 471854010828 Putative Catalytic site; other site 471854010829 DXD motif; other site 471854010830 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471854010831 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471854010832 nucleotide binding site [chemical binding]; other site 471854010833 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 471854010834 classical (c) SDRs; Region: SDR_c; cd05233 471854010835 NAD(P) binding site [chemical binding]; other site 471854010836 active site 471854010837 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 471854010838 Permease; Region: Permease; pfam02405 471854010839 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 471854010840 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 471854010841 Walker A/P-loop; other site 471854010842 ATP binding site [chemical binding]; other site 471854010843 Q-loop/lid; other site 471854010844 ABC transporter signature motif; other site 471854010845 Walker B; other site 471854010846 D-loop; other site 471854010847 H-loop/switch region; other site 471854010848 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 471854010849 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 471854010850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471854010851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471854010852 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 471854010853 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 471854010854 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 471854010855 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 471854010856 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 471854010857 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 471854010858 putative Iron-sulfur protein interface [polypeptide binding]; other site 471854010859 proximal heme binding site [chemical binding]; other site 471854010860 distal heme binding site [chemical binding]; other site 471854010861 putative dimer interface [polypeptide binding]; other site 471854010862 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 471854010863 L-aspartate oxidase; Provisional; Region: PRK06175 471854010864 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471854010865 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 471854010866 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 471854010867 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471854010868 putative active site [active] 471854010869 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 471854010870 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 471854010871 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 471854010872 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 471854010873 active site 471854010874 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 471854010875 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 471854010876 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 471854010877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854010878 non-specific DNA binding site [nucleotide binding]; other site 471854010879 salt bridge; other site 471854010880 sequence-specific DNA binding site [nucleotide binding]; other site 471854010881 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 471854010882 Divergent AAA domain; Region: AAA_4; pfam04326 471854010883 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 471854010884 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 471854010885 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 471854010886 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471854010887 homodimer interface [polypeptide binding]; other site 471854010888 substrate-cofactor binding pocket; other site 471854010889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854010890 catalytic residue [active] 471854010891 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 471854010892 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 471854010893 Na binding site [ion binding]; other site 471854010894 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471854010895 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471854010896 inhibitor site; inhibition site 471854010897 active site 471854010898 dimer interface [polypeptide binding]; other site 471854010899 catalytic residue [active] 471854010900 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854010901 Cupin domain; Region: Cupin_2; cl17218 471854010902 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471854010903 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854010904 Predicted membrane protein [Function unknown]; Region: COG2259 471854010905 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 471854010906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854010907 putative substrate translocation pore; other site 471854010908 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471854010909 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 471854010910 peptide chain release factor 2; Validated; Region: prfB; PRK00578 471854010911 This domain is found in peptide chain release factors; Region: PCRF; smart00937 471854010912 RF-1 domain; Region: RF-1; pfam00472 471854010913 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 471854010914 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471854010915 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471854010916 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471854010917 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 471854010918 Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802 471854010919 putative active site [active] 471854010920 YdjC motif; other site 471854010921 Mg binding site [ion binding]; other site 471854010922 homodimer interface [polypeptide binding]; other site 471854010923 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 471854010924 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 471854010925 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471854010926 putative ribose interaction site [chemical binding]; other site 471854010927 putative ADP binding site [chemical binding]; other site 471854010928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854010929 Coenzyme A binding pocket [chemical binding]; other site 471854010930 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 471854010931 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 471854010932 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 471854010933 dimerization interface [polypeptide binding]; other site 471854010934 active site 471854010935 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 471854010936 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 471854010937 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 471854010938 hypothetical protein; Validated; Region: PRK00153 471854010939 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471854010940 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 471854010941 Probable Catalytic site; other site 471854010942 metal-binding site 471854010943 PspC domain; Region: PspC; pfam04024 471854010944 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 471854010945 DNA-binding site [nucleotide binding]; DNA binding site 471854010946 RNA-binding motif; other site 471854010947 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 471854010948 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 471854010949 dimer interface [polypeptide binding]; other site 471854010950 putative anticodon binding site; other site 471854010951 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 471854010952 motif 1; other site 471854010953 active site 471854010954 motif 2; other site 471854010955 motif 3; other site 471854010956 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 471854010957 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471854010958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854010959 active site 471854010960 phosphorylation site [posttranslational modification] 471854010961 intermolecular recognition site; other site 471854010962 dimerization interface [polypeptide binding]; other site 471854010963 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471854010964 DNA binding site [nucleotide binding] 471854010965 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 471854010966 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471854010967 GldH lipoprotein; Region: GldH_lipo; pfam14109 471854010968 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 471854010969 Cysteine-rich domain; Region: CCG; pfam02754 471854010970 Cysteine-rich domain; Region: CCG; pfam02754 471854010971 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471854010972 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 471854010973 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 471854010974 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854010975 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471854010976 colanic acid exporter; Provisional; Region: PRK10459 471854010977 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 471854010978 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854010979 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471854010980 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 471854010981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854010982 S-adenosylmethionine binding site [chemical binding]; other site 471854010983 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 471854010984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 471854010985 Transposase; Region: DDE_Tnp_ISL3; pfam01610 471854010986 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 471854010987 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471854010988 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471854010989 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471854010990 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471854010991 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 471854010992 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471854010993 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471854010994 catalytic residues [active] 471854010995 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854010996 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854010997 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471854010998 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471854010999 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 471854011000 putative NAD(P) binding site [chemical binding]; other site 471854011001 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854011002 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854011003 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 471854011004 putative glycosyl transferase; Provisional; Region: PRK10307 471854011005 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 471854011006 4Fe-4S binding domain; Region: Fer4; pfam00037 471854011007 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 471854011008 4Fe-4S binding domain; Region: Fer4; pfam00037 471854011009 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 471854011010 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 471854011011 Protein of unknown function, DUF606; Region: DUF606; pfam04657 471854011012 AAA domain; Region: AAA_14; pfam13173 471854011013 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 471854011014 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 471854011015 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 471854011016 active site 471854011017 Recombination protein O N terminal; Region: RecO_N; pfam11967 471854011018 Recombination protein O C terminal; Region: RecO_C; pfam02565 471854011019 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 471854011020 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 471854011021 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 471854011022 Walker A/P-loop; other site 471854011023 ATP binding site [chemical binding]; other site 471854011024 Q-loop/lid; other site 471854011025 ABC transporter signature motif; other site 471854011026 Walker B; other site 471854011027 D-loop; other site 471854011028 H-loop/switch region; other site 471854011029 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 471854011030 DHH family; Region: DHH; pfam01368 471854011031 DHHA1 domain; Region: DHHA1; pfam02272 471854011032 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 471854011033 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471854011034 active site 471854011035 catalytic residues [active] 471854011036 metal binding site [ion binding]; metal-binding site 471854011037 C-N hydrolase family amidase; Provisional; Region: PRK10438 471854011038 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 471854011039 putative active site [active] 471854011040 catalytic triad [active] 471854011041 dimer interface [polypeptide binding]; other site 471854011042 multimer interface [polypeptide binding]; other site 471854011043 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 471854011044 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 471854011045 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 471854011046 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 471854011047 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 471854011048 PBP superfamily domain; Region: PBP_like_2; pfam12849 471854011049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 471854011050 binding surface 471854011051 TPR motif; other site 471854011052 TPR repeat; Region: TPR_11; pfam13414 471854011053 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854011054 binding surface 471854011055 TPR motif; other site 471854011056 Oxygen tolerance; Region: BatD; pfam13584 471854011057 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 471854011058 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 471854011059 Tetramer interface [polypeptide binding]; other site 471854011060 active site 471854011061 FMN-binding site [chemical binding]; other site 471854011062 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854011063 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854011064 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 471854011065 Uncharacterized conserved protein [Function unknown]; Region: COG1262 471854011066 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471854011067 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471854011068 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471854011069 ABC transporter; Region: ABC_tran_2; pfam12848 471854011070 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471854011071 Uncharacterized conserved protein [Function unknown]; Region: COG0398 471854011072 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471854011073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854011074 non-specific DNA binding site [nucleotide binding]; other site 471854011075 salt bridge; other site 471854011076 sequence-specific DNA binding site [nucleotide binding]; other site 471854011077 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 471854011078 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 471854011079 trimer interface [polypeptide binding]; other site 471854011080 putative metal binding site [ion binding]; other site 471854011081 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 471854011082 phosphodiesterase YaeI; Provisional; Region: PRK11340 471854011083 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 471854011084 putative active site [active] 471854011085 putative metal binding site [ion binding]; other site 471854011086 glycine dehydrogenase; Provisional; Region: PRK05367 471854011087 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 471854011088 tetramer interface [polypeptide binding]; other site 471854011089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854011090 catalytic residue [active] 471854011091 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 471854011092 tetramer interface [polypeptide binding]; other site 471854011093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854011094 catalytic residue [active] 471854011095 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 471854011096 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 471854011097 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 471854011098 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471854011099 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 471854011100 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471854011101 catalytic loop [active] 471854011102 iron binding site [ion binding]; other site 471854011103 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 471854011104 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 471854011105 SLBB domain; Region: SLBB; pfam10531 471854011106 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 471854011107 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 471854011108 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 471854011109 putative dimer interface [polypeptide binding]; other site 471854011110 [2Fe-2S] cluster binding site [ion binding]; other site 471854011111 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 471854011112 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 471854011113 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 471854011114 NADH dehydrogenase subunit B; Provisional; Region: PRK14820 471854011115 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 471854011116 Domain of unknown function (DUF303); Region: DUF303; pfam03629 471854011117 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854011118 Domain of unknown function (DUF303); Region: DUF303; pfam03629 471854011119 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854011120 GTPase CgtA; Reviewed; Region: obgE; PRK12299 471854011121 GTP1/OBG; Region: GTP1_OBG; pfam01018 471854011122 Obg GTPase; Region: Obg; cd01898 471854011123 G1 box; other site 471854011124 GTP/Mg2+ binding site [chemical binding]; other site 471854011125 Switch I region; other site 471854011126 G2 box; other site 471854011127 G3 box; other site 471854011128 Switch II region; other site 471854011129 G4 box; other site 471854011130 G5 box; other site 471854011131 adenylate kinase; Reviewed; Region: adk; PRK00279 471854011132 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 471854011133 AMP-binding site [chemical binding]; other site 471854011134 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 471854011135 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 471854011136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854011137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854011138 dimer interface [polypeptide binding]; other site 471854011139 phosphorylation site [posttranslational modification] 471854011140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854011141 ATP binding site [chemical binding]; other site 471854011142 Mg2+ binding site [ion binding]; other site 471854011143 G-X-G motif; other site 471854011144 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 471854011145 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471854011146 active site 471854011147 HIGH motif; other site 471854011148 nucleotide binding site [chemical binding]; other site 471854011149 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471854011150 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 471854011151 active site 471854011152 KMSKS motif; other site 471854011153 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 471854011154 tRNA binding surface [nucleotide binding]; other site 471854011155 anticodon binding site; other site 471854011156 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 471854011157 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 471854011158 AMP binding site [chemical binding]; other site 471854011159 metal binding site [ion binding]; metal-binding site 471854011160 active site 471854011161 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 471854011162 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471854011163 ATP binding site [chemical binding]; other site 471854011164 Mg++ binding site [ion binding]; other site 471854011165 motif III; other site 471854011166 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854011167 nucleotide binding region [chemical binding]; other site 471854011168 ATP-binding site [chemical binding]; other site 471854011169 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854011170 binding surface 471854011171 TPR motif; other site 471854011172 TPR repeat; Region: TPR_11; pfam13414 471854011173 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854011174 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 471854011175 EamA-like transporter family; Region: EamA; pfam00892 471854011176 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471854011177 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 471854011178 peptide chain release factor 1; Validated; Region: prfA; PRK00591 471854011179 This domain is found in peptide chain release factors; Region: PCRF; smart00937 471854011180 RF-1 domain; Region: RF-1; pfam00472 471854011181 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471854011182 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471854011183 active site 471854011184 catalytic tetrad [active] 471854011185 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471854011186 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471854011187 dimer interface [polypeptide binding]; other site 471854011188 ssDNA binding site [nucleotide binding]; other site 471854011189 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471854011190 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 471854011191 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471854011192 nucleotide binding site [chemical binding]; other site 471854011193 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471854011194 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 471854011195 PA/protease or protease-like domain interface [polypeptide binding]; other site 471854011196 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 471854011197 Peptidase family M28; Region: Peptidase_M28; pfam04389 471854011198 metal binding site [ion binding]; metal-binding site 471854011199 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609 471854011200 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 471854011201 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 471854011202 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 471854011203 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854011204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854011205 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 471854011206 Acyltransferase family; Region: Acyl_transf_3; pfam01757 471854011207 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471854011208 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471854011209 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854011210 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 471854011211 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471854011212 ligand binding site [chemical binding]; other site 471854011213 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 471854011214 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471854011215 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471854011216 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471854011217 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854011218 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 471854011219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854011220 Walker A/P-loop; other site 471854011221 ATP binding site [chemical binding]; other site 471854011222 Q-loop/lid; other site 471854011223 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471854011224 ABC transporter; Region: ABC_tran_2; pfam12848 471854011225 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471854011226 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471854011227 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471854011228 DNA binding site [nucleotide binding] 471854011229 domain linker motif; other site 471854011230 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471854011231 dimerization interface [polypeptide binding]; other site 471854011232 ligand binding site [chemical binding]; other site 471854011233 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854011234 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854011235 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854011236 DNA binding residues [nucleotide binding] 471854011237 mannonate dehydratase; Region: uxuA; TIGR00695 471854011238 mannonate dehydratase; Provisional; Region: PRK03906 471854011239 Glucuronate isomerase; Region: UxaC; pfam02614 471854011240 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 471854011241 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 471854011242 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471854011243 substrate binding site [chemical binding]; other site 471854011244 ATP binding site [chemical binding]; other site 471854011245 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 471854011246 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 471854011247 active site 471854011248 intersubunit interface [polypeptide binding]; other site 471854011249 catalytic residue [active] 471854011250 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 471854011251 altronate oxidoreductase; Provisional; Region: PRK03643 471854011252 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 471854011253 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 471854011254 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 471854011255 Found in ATP-dependent protease La (LON); Region: LON; smart00464 471854011256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854011257 Walker A motif; other site 471854011258 ATP binding site [chemical binding]; other site 471854011259 Walker B motif; other site 471854011260 arginine finger; other site 471854011261 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 471854011262 RIP metalloprotease RseP; Region: TIGR00054 471854011263 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 471854011264 active site 471854011265 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 471854011266 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 471854011267 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 471854011268 putative substrate binding region [chemical binding]; other site 471854011269 MutS domain III; Region: MutS_III; pfam05192 471854011270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854011271 Walker A/P-loop; other site 471854011272 ATP binding site [chemical binding]; other site 471854011273 Q-loop/lid; other site 471854011274 ABC transporter signature motif; other site 471854011275 Walker B; other site 471854011276 D-loop; other site 471854011277 H-loop/switch region; other site 471854011278 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 471854011279 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471854011280 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 471854011281 Walker A/P-loop; other site 471854011282 ATP binding site [chemical binding]; other site 471854011283 Q-loop/lid; other site 471854011284 ABC transporter signature motif; other site 471854011285 Walker B; other site 471854011286 D-loop; other site 471854011287 H-loop/switch region; other site 471854011288 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854011289 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854011290 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854011291 DNA binding residues [nucleotide binding] 471854011292 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 471854011293 iron-sulfur cluster [ion binding]; other site 471854011294 [2Fe-2S] cluster binding site [ion binding]; other site 471854011295 YceI-like domain; Region: YceI; pfam04264 471854011296 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 471854011297 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 471854011298 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471854011299 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 471854011300 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 471854011301 Type III pantothenate kinase; Region: Pan_kinase; cl17198 471854011302 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 471854011303 putative active site pocket [active] 471854011304 dimerization interface [polypeptide binding]; other site 471854011305 putative catalytic residue [active] 471854011306 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 471854011307 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854011308 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854011309 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 471854011310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854011311 non-specific DNA binding site [nucleotide binding]; other site 471854011312 salt bridge; other site 471854011313 sequence-specific DNA binding site [nucleotide binding]; other site 471854011314 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 471854011315 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471854011316 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 471854011317 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 471854011318 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 471854011319 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471854011320 carboxyltransferase (CT) interaction site; other site 471854011321 biotinylation site [posttranslational modification]; other site 471854011322 elongation factor P; Validated; Region: PRK00529 471854011323 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 471854011324 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 471854011325 RNA binding site [nucleotide binding]; other site 471854011326 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 471854011327 RNA binding site [nucleotide binding]; other site 471854011328 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 471854011329 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 471854011330 dimer interface [polypeptide binding]; other site 471854011331 active site 471854011332 CoA binding pocket [chemical binding]; other site 471854011333 putative phosphate acyltransferase; Provisional; Region: PRK05331 471854011334 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 471854011335 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 471854011336 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 471854011337 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 471854011338 putative trimer interface [polypeptide binding]; other site 471854011339 putative CoA binding site [chemical binding]; other site 471854011340 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 471854011341 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 471854011342 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 471854011343 TIGR01777 family protein; Region: yfcH 471854011344 putative NAD(P) binding site [chemical binding]; other site 471854011345 putative active site [active] 471854011346 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471854011347 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471854011348 putative acyl-acceptor binding pocket; other site 471854011349 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 471854011350 Peptidase family M48; Region: Peptidase_M48; pfam01435 471854011351 MarR family; Region: MarR_2; pfam12802 471854011352 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 471854011353 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854011354 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854011355 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 471854011356 Protein export membrane protein; Region: SecD_SecF; cl14618 471854011357 PIN domain; Region: PIN_2; pfam10130 471854011358 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 471854011359 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471854011360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854011361 non-specific DNA binding site [nucleotide binding]; other site 471854011362 salt bridge; other site 471854011363 sequence-specific DNA binding site [nucleotide binding]; other site 471854011364 Domain of unknown function (DUF955); Region: DUF955; cl01076 471854011365 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 471854011366 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 471854011367 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 471854011368 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 471854011369 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 471854011370 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 471854011371 nucleotide binding site [chemical binding]; other site 471854011372 N-acetyl-L-glutamate binding site [chemical binding]; other site 471854011373 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854011374 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854011375 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854011376 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854011377 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854011378 cytochrome c-550; Provisional; Region: psbV; PRK13622 471854011379 Family description; Region: VCBS; pfam13517 471854011380 Family description; Region: VCBS; pfam13517 471854011381 Family description; Region: VCBS; pfam13517 471854011382 Family description; Region: VCBS; pfam13517 471854011383 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 471854011384 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 471854011385 active sites [active] 471854011386 tetramer interface [polypeptide binding]; other site 471854011387 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 471854011388 NlpC/P60 family; Region: NLPC_P60; pfam00877 471854011389 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 471854011390 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 471854011391 dimerization interface [polypeptide binding]; other site 471854011392 ATP binding site [chemical binding]; other site 471854011393 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471854011394 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 471854011395 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854011396 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854011397 SusD family; Region: SusD; pfam07980 471854011398 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854011399 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854011400 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854011401 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854011402 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 471854011403 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 471854011404 active site 471854011405 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 471854011406 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471854011407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 471854011408 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 471854011409 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 471854011410 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 471854011411 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 471854011412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854011413 AAA domain; Region: AAA_23; pfam13476 471854011414 Walker A/P-loop; other site 471854011415 ATP binding site [chemical binding]; other site 471854011416 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 471854011417 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 471854011418 Int/Topo IB signature motif; other site 471854011419 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 471854011420 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 471854011421 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 471854011422 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471854011423 nucleoside/Zn binding site; other site 471854011424 dimer interface [polypeptide binding]; other site 471854011425 catalytic motif [active] 471854011426 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854011427 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471854011428 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 471854011429 Beta-lactamase; Region: Beta-lactamase; cl17358 471854011430 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471854011431 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 471854011432 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471854011433 Walker A/P-loop; other site 471854011434 ATP binding site [chemical binding]; other site 471854011435 Q-loop/lid; other site 471854011436 ABC transporter signature motif; other site 471854011437 Walker B; other site 471854011438 D-loop; other site 471854011439 H-loop/switch region; other site 471854011440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 471854011441 AAA domain; Region: AAA_14; pfam13173 471854011442 AAA domain; Region: AAA_22; pfam13401 471854011443 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 471854011444 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 471854011445 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471854011446 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 471854011447 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 471854011448 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471854011449 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471854011450 Beta-lactamase; Region: Beta-lactamase; pfam00144 471854011451 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 471854011452 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 471854011453 putative dimer interface [polypeptide binding]; other site 471854011454 putative anticodon binding site; other site 471854011455 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 471854011456 homodimer interface [polypeptide binding]; other site 471854011457 motif 1; other site 471854011458 motif 2; other site 471854011459 active site 471854011460 motif 3; other site 471854011461 enoyl-CoA hydratase; Provisional; Region: PRK06688 471854011462 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471854011463 substrate binding site [chemical binding]; other site 471854011464 oxyanion hole (OAH) forming residues; other site 471854011465 trimer interface [polypeptide binding]; other site 471854011466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854011467 non-specific DNA binding site [nucleotide binding]; other site 471854011468 salt bridge; other site 471854011469 sequence-specific DNA binding site [nucleotide binding]; other site 471854011470 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854011471 SusD family; Region: SusD; pfam07980 471854011472 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854011473 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854011474 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854011475 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854011476 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 471854011477 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854011478 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854011479 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854011480 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854011481 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854011482 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471854011483 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471854011484 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471854011485 active site residue [active] 471854011486 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854011487 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 471854011488 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854011489 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854011490 glycerate dehydrogenase; Provisional; Region: PRK06487 471854011491 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 471854011492 putative ligand binding site [chemical binding]; other site 471854011493 putative NAD binding site [chemical binding]; other site 471854011494 catalytic site [active] 471854011495 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 471854011496 Zn binding site [ion binding]; other site 471854011497 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 471854011498 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 471854011499 putative active site [active] 471854011500 Zn binding site [ion binding]; other site 471854011501 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 471854011502 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 471854011503 putative active site [active] 471854011504 oxyanion strand; other site 471854011505 catalytic triad [active] 471854011506 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 471854011507 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 471854011508 catalytic residues [active] 471854011509 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 471854011510 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 471854011511 substrate binding site [chemical binding]; other site 471854011512 glutamase interaction surface [polypeptide binding]; other site 471854011513 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 471854011514 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 471854011515 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 471854011516 metal binding site [ion binding]; metal-binding site 471854011517 Membrane protein of unknown function; Region: DUF360; pfam04020 471854011518 geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169 471854011519 PcrB family; Region: PcrB; pfam01884 471854011520 phosphate binding site [ion binding]; other site 471854011521 SprT-like family; Region: SprT-like; pfam10263 471854011522 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 471854011523 active site 471854011524 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471854011525 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471854011526 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 471854011527 DNA photolyase; Region: DNA_photolyase; pfam00875 471854011528 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854011529 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 471854011530 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 471854011531 hinge; other site 471854011532 active site 471854011533 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 471854011534 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 471854011535 active site 471854011536 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471854011537 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 471854011538 folate binding site [chemical binding]; other site 471854011539 NADP+ binding site [chemical binding]; other site 471854011540 Predicted transcriptional regulators [Transcription]; Region: COG1695 471854011541 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471854011542 PspC domain; Region: PspC; pfam04024 471854011543 PspC domain; Region: PspC; pfam04024 471854011544 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 471854011545 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 471854011546 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 471854011547 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471854011548 homotrimer interaction site [polypeptide binding]; other site 471854011549 putative active site [active] 471854011550 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 471854011551 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471854011552 HIGH motif; other site 471854011553 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471854011554 active site 471854011555 KMSKS motif; other site 471854011556 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 471854011557 Domain of unknown function (DUF303); Region: DUF303; pfam03629 471854011558 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854011559 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854011560 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854011561 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854011562 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854011563 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854011564 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854011565 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854011566 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854011567 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854011568 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854011569 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854011570 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854011571 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854011572 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471854011573 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471854011574 inhibitor site; inhibition site 471854011575 active site 471854011576 dimer interface [polypeptide binding]; other site 471854011577 catalytic residue [active] 471854011578 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 471854011579 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 471854011580 dimer interface [polypeptide binding]; other site 471854011581 NADP binding site [chemical binding]; other site 471854011582 catalytic residues [active] 471854011583 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 471854011584 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 471854011585 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 471854011586 hydroxyglutarate oxidase; Provisional; Region: PRK11728 471854011587 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 471854011588 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 471854011589 putative hydrophobic ligand binding site [chemical binding]; other site 471854011590 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471854011591 dimerization interface [polypeptide binding]; other site 471854011592 putative DNA binding site [nucleotide binding]; other site 471854011593 putative Zn2+ binding site [ion binding]; other site 471854011594 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 471854011595 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 471854011596 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 471854011597 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 471854011598 5-oxoprolinase; Region: PLN02666 471854011599 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 471854011600 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 471854011601 Cupin domain; Region: Cupin_2; cl17218 471854011602 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471854011603 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854011604 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 471854011605 substrate binding site [chemical binding]; other site 471854011606 active site 471854011607 Protein of unknown function (DUF3823); Region: DUF3823; pfam12866 471854011608 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854011609 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854011610 SusD family; Region: SusD; pfam07980 471854011611 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854011612 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854011613 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854011614 Trehalose utilisation; Region: ThuA; pfam06283 471854011615 conserved cys residue [active] 471854011616 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 471854011617 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 471854011618 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 471854011619 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854011620 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854011621 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471854011622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854011623 Coenzyme A binding pocket [chemical binding]; other site 471854011624 Uncharacterized conserved protein [Function unknown]; Region: COG3538 471854011625 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 471854011626 biotin synthase; Region: bioB; TIGR00433 471854011627 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471854011628 FeS/SAM binding site; other site 471854011629 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 471854011630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 471854011631 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 471854011632 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 471854011633 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 471854011634 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 471854011635 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854011636 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 471854011637 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854011638 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854011639 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471854011640 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471854011641 DNA interaction; other site 471854011642 Metal-binding active site; metal-binding site 471854011643 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 471854011644 tRNA ligase kinase domain; Region: tRNA_lig_kinase; pfam08303 471854011645 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 471854011646 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854011647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854011648 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854011649 non-specific DNA binding site [nucleotide binding]; other site 471854011650 salt bridge; other site 471854011651 sequence-specific DNA binding site [nucleotide binding]; other site 471854011652 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854011653 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854011654 Trehalose utilisation; Region: ThuA; pfam06283 471854011655 conserved cys residue [active] 471854011656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854011657 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 471854011658 NAD(P) binding site [chemical binding]; other site 471854011659 active site 471854011660 mannonate dehydratase; Provisional; Region: PRK03906 471854011661 mannonate dehydratase; Region: uxuA; TIGR00695 471854011662 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471854011663 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471854011664 DNA binding site [nucleotide binding] 471854011665 domain linker motif; other site 471854011666 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471854011667 dimerization interface [polypeptide binding]; other site 471854011668 ligand binding site [chemical binding]; other site 471854011669 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471854011670 putative active site [active] 471854011671 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 471854011672 Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802 471854011673 putative active site [active] 471854011674 YdjC motif; other site 471854011675 Mg binding site [ion binding]; other site 471854011676 homodimer interface [polypeptide binding]; other site 471854011677 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 471854011678 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471854011679 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 471854011680 substrate binding site [chemical binding]; other site 471854011681 ATP binding site [chemical binding]; other site 471854011682 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 471854011683 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 471854011684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471854011685 motif II; other site 471854011686 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854011687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854011688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854011689 DNA binding residues [nucleotide binding] 471854011690 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 471854011691 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 471854011692 Haemolytic domain; Region: Haemolytic; pfam01809 471854011693 MoxR-like ATPases [General function prediction only]; Region: COG0714 471854011694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854011695 Walker A motif; other site 471854011696 ATP binding site [chemical binding]; other site 471854011697 Walker B motif; other site 471854011698 arginine finger; other site 471854011699 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 471854011700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854011701 S-adenosylmethionine binding site [chemical binding]; other site 471854011702 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 471854011703 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 471854011704 catalytic motif [active] 471854011705 Zn binding site [ion binding]; other site 471854011706 RibD C-terminal domain; Region: RibD_C; cl17279 471854011707 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 471854011708 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 471854011709 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 471854011710 shikimate binding site; other site 471854011711 NAD(P) binding site [chemical binding]; other site 471854011712 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 471854011713 active site 471854011714 catalytic triad [active] 471854011715 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 471854011716 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 471854011717 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854011718 NH_2: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_2; cd02652 471854011719 active site 471854011720 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 471854011721 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 471854011722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 471854011723 Putative carbohydrate binding domain; Region: CHB_HEX; cl03918 471854011724 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 471854011725 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 471854011726 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 471854011727 active site 471854011728 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 471854011729 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471854011730 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471854011731 nucleotide binding site [chemical binding]; other site 471854011732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854011733 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 471854011734 putative substrate translocation pore; other site 471854011735 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 471854011736 putative dimerization interface [polypeptide binding]; other site 471854011737 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471854011738 putative ligand binding site [chemical binding]; other site 471854011739 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854011740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854011741 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 471854011742 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 471854011743 active site 471854011744 Zn binding site [ion binding]; other site 471854011745 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 471854011746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854011747 putative substrate translocation pore; other site 471854011748 POT family; Region: PTR2; cl17359 471854011749 Protein of unknown function (DUF904); Region: DUF904; cl11531 471854011750 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 471854011751 Repair protein; Region: Repair_PSII; pfam04536 471854011752 Repair protein; Region: Repair_PSII; pfam04536 471854011753 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 471854011754 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 471854011755 DNA photolyase; Region: DNA_photolyase; pfam00875 471854011756 Tetratricopeptide repeat; Region: TPR_16; pfam13432 471854011757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854011758 TPR motif; other site 471854011759 binding surface 471854011760 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471854011761 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471854011762 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 471854011763 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471854011764 ligand binding site [chemical binding]; other site 471854011765 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 471854011766 S17 interaction site [polypeptide binding]; other site 471854011767 S8 interaction site; other site 471854011768 16S rRNA interaction site [nucleotide binding]; other site 471854011769 streptomycin interaction site [chemical binding]; other site 471854011770 23S rRNA interaction site [nucleotide binding]; other site 471854011771 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 471854011772 30S ribosomal protein S7; Validated; Region: PRK05302 471854011773 elongation factor G; Reviewed; Region: PRK12739 471854011774 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 471854011775 G1 box; other site 471854011776 putative GEF interaction site [polypeptide binding]; other site 471854011777 GTP/Mg2+ binding site [chemical binding]; other site 471854011778 Switch I region; other site 471854011779 G2 box; other site 471854011780 G3 box; other site 471854011781 Switch II region; other site 471854011782 G4 box; other site 471854011783 G5 box; other site 471854011784 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 471854011785 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 471854011786 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 471854011787 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 471854011788 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 471854011789 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 471854011790 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 471854011791 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 471854011792 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 471854011793 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 471854011794 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 471854011795 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 471854011796 putative translocon binding site; other site 471854011797 protein-rRNA interface [nucleotide binding]; other site 471854011798 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 471854011799 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 471854011800 G-X-X-G motif; other site 471854011801 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 471854011802 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 471854011803 23S rRNA interface [nucleotide binding]; other site 471854011804 5S rRNA interface [nucleotide binding]; other site 471854011805 putative antibiotic binding site [chemical binding]; other site 471854011806 L25 interface [polypeptide binding]; other site 471854011807 L27 interface [polypeptide binding]; other site 471854011808 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 471854011809 23S rRNA interface [nucleotide binding]; other site 471854011810 putative translocon interaction site; other site 471854011811 signal recognition particle (SRP54) interaction site; other site 471854011812 L23 interface [polypeptide binding]; other site 471854011813 trigger factor interaction site; other site 471854011814 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 471854011815 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 471854011816 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 471854011817 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 471854011818 RNA binding site [nucleotide binding]; other site 471854011819 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 471854011820 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 471854011821 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 471854011822 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 471854011823 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 471854011824 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 471854011825 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471854011826 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471854011827 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 471854011828 23S rRNA interface [nucleotide binding]; other site 471854011829 L21e interface [polypeptide binding]; other site 471854011830 5S rRNA interface [nucleotide binding]; other site 471854011831 L27 interface [polypeptide binding]; other site 471854011832 L5 interface [polypeptide binding]; other site 471854011833 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 471854011834 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 471854011835 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 471854011836 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 471854011837 23S rRNA binding site [nucleotide binding]; other site 471854011838 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 471854011839 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 471854011840 SecY translocase; Region: SecY; pfam00344 471854011841 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471854011842 active site 471854011843 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 471854011844 rRNA binding site [nucleotide binding]; other site 471854011845 predicted 30S ribosome binding site; other site 471854011846 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 471854011847 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 471854011848 30S ribosomal protein S13; Region: bact_S13; TIGR03631 471854011849 30S ribosomal protein S11; Validated; Region: PRK05309 471854011850 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 471854011851 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 471854011852 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471854011853 RNA binding surface [nucleotide binding]; other site 471854011854 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 471854011855 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 471854011856 alphaNTD - beta interaction site [polypeptide binding]; other site 471854011857 alphaNTD homodimer interface [polypeptide binding]; other site 471854011858 alphaNTD - beta' interaction site [polypeptide binding]; other site 471854011859 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 471854011860 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 471854011861 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 471854011862 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 471854011863 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 471854011864 catalytic site [active] 471854011865 subunit interface [polypeptide binding]; other site 471854011866 enolase; Provisional; Region: eno; PRK00077 471854011867 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 471854011868 dimer interface [polypeptide binding]; other site 471854011869 metal binding site [ion binding]; metal-binding site 471854011870 substrate binding pocket [chemical binding]; other site 471854011871 Septum formation initiator; Region: DivIC; pfam04977 471854011872 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 471854011873 phosphoglyceromutase; Provisional; Region: PRK05434 471854011874 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 471854011875 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 471854011876 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 471854011877 active site 471854011878 dimerization interface [polypeptide binding]; other site 471854011879 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471854011880 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471854011881 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 471854011882 DHH family; Region: DHH; pfam01368 471854011883 DHHA1 domain; Region: DHHA1; pfam02272 471854011884 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 471854011885 active site 471854011886 multimer interface [polypeptide binding]; other site 471854011887 Fasciclin domain; Region: Fasciclin; pfam02469 471854011888 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854011889 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 471854011890 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 471854011891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471854011892 Histidine kinase; Region: His_kinase; pfam06580 471854011893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854011894 ATP binding site [chemical binding]; other site 471854011895 Mg2+ binding site [ion binding]; other site 471854011896 G-X-G motif; other site 471854011897 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854011898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854011899 active site 471854011900 phosphorylation site [posttranslational modification] 471854011901 intermolecular recognition site; other site 471854011902 dimerization interface [polypeptide binding]; other site 471854011903 LytTr DNA-binding domain; Region: LytTR; smart00850 471854011904 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 471854011905 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 471854011906 catalytic residue [active] 471854011907 putative FPP diphosphate binding site; other site 471854011908 putative FPP binding hydrophobic cleft; other site 471854011909 dimer interface [polypeptide binding]; other site 471854011910 putative IPP diphosphate binding site; other site 471854011911 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 471854011912 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 471854011913 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 471854011914 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 471854011915 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 471854011916 Surface antigen; Region: Bac_surface_Ag; pfam01103 471854011917 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 471854011918 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 471854011919 lipoprotein signal peptidase; Provisional; Region: PRK14788 471854011920 proline dehydrogenase; Region: PLN02681 471854011921 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 471854011922 Chorismate mutase type II; Region: CM_2; smart00830 471854011923 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471854011924 active site 471854011925 catalytic triad [active] 471854011926 oxyanion hole [active] 471854011927 thymidine kinase; Provisional; Region: PRK04296 471854011928 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 471854011929 active site 471854011930 catalytic residues [active] 471854011931 metal binding site [ion binding]; metal-binding site 471854011932 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471854011933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854011934 NAD(P) binding site [chemical binding]; other site 471854011935 active site 471854011936 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854011937 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854011938 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854011939 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 471854011940 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 471854011941 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471854011942 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471854011943 putative DNA binding site [nucleotide binding]; other site 471854011944 putative Zn2+ binding site [ion binding]; other site 471854011945 AsnC family; Region: AsnC_trans_reg; pfam01037 471854011946 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471854011947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854011948 NAD(P) binding site [chemical binding]; other site 471854011949 active site 471854011950 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 471854011951 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 471854011952 substrate-cofactor binding pocket; other site 471854011953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854011954 catalytic residue [active] 471854011955 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 471854011956 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 471854011957 Uncharacterized conserved protein [Function unknown]; Region: COG2353 471854011958 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854011959 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854011960 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471854011961 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 471854011962 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 471854011963 Domain of unknown function DUF87; Region: DUF87; pfam01935 471854011964 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 471854011965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 471854011966 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 471854011967 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 471854011968 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 471854011969 active site 471854011970 substrate binding site [chemical binding]; other site 471854011971 metal binding site [ion binding]; metal-binding site 471854011972 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 471854011973 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 471854011974 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471854011975 catalytic residue [active] 471854011976 ferrochelatase; Reviewed; Region: hemH; PRK00035 471854011977 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 471854011978 C-terminal domain interface [polypeptide binding]; other site 471854011979 active site 471854011980 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 471854011981 active site 471854011982 N-terminal domain interface [polypeptide binding]; other site 471854011983 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 471854011984 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471854011985 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 471854011986 acetylornithine aminotransferase; Provisional; Region: PRK02627 471854011987 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471854011988 inhibitor-cofactor binding pocket; inhibition site 471854011989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854011990 catalytic residue [active] 471854011991 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 471854011992 oligomeric interface; other site 471854011993 putative active site [active] 471854011994 homodimer interface [polypeptide binding]; other site 471854011995 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 471854011996 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 471854011997 argininosuccinate synthase; Provisional; Region: PRK13820 471854011998 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 471854011999 Ligand Binding Site [chemical binding]; other site 471854012000 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854012001 non-specific DNA binding site [nucleotide binding]; other site 471854012002 salt bridge; other site 471854012003 sequence-specific DNA binding site [nucleotide binding]; other site 471854012004 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 471854012005 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471854012006 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854012007 Coenzyme A binding pocket [chemical binding]; other site 471854012008 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 471854012009 gamma-glutamyl kinase; Provisional; Region: PRK05429 471854012010 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 471854012011 nucleotide binding site [chemical binding]; other site 471854012012 homotetrameric interface [polypeptide binding]; other site 471854012013 putative phosphate binding site [ion binding]; other site 471854012014 putative allosteric binding site; other site 471854012015 PUA domain; Region: PUA; pfam01472 471854012016 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 471854012017 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 471854012018 putative catalytic cysteine [active] 471854012019 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 471854012020 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 471854012021 metal binding site [ion binding]; metal-binding site 471854012022 dimer interface [polypeptide binding]; other site 471854012023 enoyl-CoA hydratase; Provisional; Region: PRK05995 471854012024 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471854012025 substrate binding site [chemical binding]; other site 471854012026 oxyanion hole (OAH) forming residues; other site 471854012027 trimer interface [polypeptide binding]; other site 471854012028 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 471854012029 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 471854012030 homodimer interface [polypeptide binding]; other site 471854012031 oligonucleotide binding site [chemical binding]; other site 471854012032 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 471854012033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854012034 binding surface 471854012035 TPR motif; other site 471854012036 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 471854012037 IHF - DNA interface [nucleotide binding]; other site 471854012038 IHF dimer interface [polypeptide binding]; other site 471854012039 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471854012040 endonuclease III; Region: ENDO3c; smart00478 471854012041 minor groove reading motif; other site 471854012042 helix-hairpin-helix signature motif; other site 471854012043 substrate binding pocket [chemical binding]; other site 471854012044 active site 471854012045 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 471854012046 DNA binding and oxoG recognition site [nucleotide binding] 471854012047 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 471854012048 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854012049 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854012050 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471854012051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471854012052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471854012053 dimer interface [polypeptide binding]; other site 471854012054 ssDNA binding site [nucleotide binding]; other site 471854012055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471854012056 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471854012057 Transporter associated domain; Region: CorC_HlyC; pfam03471 471854012058 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 471854012059 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 471854012060 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 471854012061 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 471854012062 active site 471854012063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 471854012064 Integrase core domain; Region: rve; pfam00665 471854012065 Integrase core domain; Region: rve_3; pfam13683 471854012066 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471854012067 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 471854012068 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 471854012069 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471854012070 CoenzymeA binding site [chemical binding]; other site 471854012071 subunit interaction site [polypeptide binding]; other site 471854012072 PHB binding site; other site 471854012073 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 471854012074 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 471854012075 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 471854012076 homodimer interface [polypeptide binding]; other site 471854012077 metal binding site [ion binding]; metal-binding site 471854012078 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 471854012079 homodimer interface [polypeptide binding]; other site 471854012080 active site 471854012081 putative chemical substrate binding site [chemical binding]; other site 471854012082 metal binding site [ion binding]; metal-binding site 471854012083 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471854012084 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 471854012085 Thiamine pyrophosphokinase; Region: TPK; cd07995 471854012086 active site 471854012087 dimerization interface [polypeptide binding]; other site 471854012088 thiamine binding site [chemical binding]; other site 471854012089 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 471854012090 Zn binding site [ion binding]; other site 471854012091 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 471854012092 Galactose oxidase, central domain; Region: Kelch_3; cl02701 471854012093 Kelch motif; Region: Kelch_6; pfam13964 471854012094 Galactose oxidase, central domain; Region: Kelch_3; cl02701 471854012095 Kelch motif; Region: Kelch_1; pfam01344 471854012096 Kelch motif; Region: Kelch_1; pfam01344 471854012097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 471854012098 Putative glucoamylase; Region: Glycoamylase; pfam10091 471854012099 Bacterial Ig-like domain; Region: Big_5; pfam13205 471854012100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 471854012101 Putative glucoamylase; Region: Glycoamylase; pfam10091 471854012102 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 471854012103 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854012104 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854012105 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854012106 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854012107 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854012108 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 471854012109 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 471854012110 DNA binding residues [nucleotide binding] 471854012111 dimerization interface [polypeptide binding]; other site 471854012112 malate dehydrogenase; Reviewed; Region: PRK06223 471854012113 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 471854012114 dimer interface [polypeptide binding]; other site 471854012115 NAD(P) binding site [chemical binding]; other site 471854012116 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471854012117 substrate binding site [chemical binding]; other site 471854012118 Uncharacterized conserved protein [Function unknown]; Region: COG3339 471854012119 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 471854012120 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471854012121 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 471854012122 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 471854012123 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471854012124 catalytic residue [active] 471854012125 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471854012126 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471854012127 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 471854012128 RuvA N terminal domain; Region: RuvA_N; pfam01330 471854012129 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 471854012130 cell surface protein SprA; Region: surface_SprA; TIGR04189 471854012131 Motility related/secretion protein; Region: SprA_N; pfam14349 471854012132 Motility related/secretion protein; Region: SprA_N; pfam14349 471854012133 Motility related/secretion protein; Region: SprA_N; pfam14349 471854012134 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 471854012135 lipoyl attachment site [posttranslational modification]; other site 471854012136 dihydroorotase; Validated; Region: pyrC; PRK09357 471854012137 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854012138 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 471854012139 active site 471854012140 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 471854012141 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 471854012142 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 471854012143 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 471854012144 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854012145 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854012146 DNA binding residues [nucleotide binding] 471854012147 Anti-sigma-K factor rskA; Region: RskA; pfam10099 471854012148 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471854012149 KTSC domain; Region: KTSC; pfam13619 471854012150 HerA helicase [Replication, recombination, and repair]; Region: COG0433 471854012151 Domain of unknown function DUF87; Region: DUF87; pfam01935 471854012152 AAA-like domain; Region: AAA_10; pfam12846 471854012153 SIR2-like domain; Region: SIR2_2; pfam13289 471854012154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854012155 non-specific DNA binding site [nucleotide binding]; other site 471854012156 salt bridge; other site 471854012157 sequence-specific DNA binding site [nucleotide binding]; other site 471854012158 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 471854012159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 471854012160 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 471854012161 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854012162 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 471854012163 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 471854012164 active site 471854012165 trimer interface [polypeptide binding]; other site 471854012166 allosteric site; other site 471854012167 active site lid [active] 471854012168 hexamer (dimer of trimers) interface [polypeptide binding]; other site 471854012169 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 471854012170 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 471854012171 active site 471854012172 dimer interface [polypeptide binding]; other site 471854012173 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 471854012174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854012175 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854012176 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854012177 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 471854012178 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 471854012179 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471854012180 inhibitor-cofactor binding pocket; inhibition site 471854012181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854012182 catalytic residue [active] 471854012183 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854012184 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471854012185 DNA binding site [nucleotide binding] 471854012186 domain linker motif; other site 471854012187 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 471854012188 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 471854012189 ligand binding site [chemical binding]; other site 471854012190 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 471854012191 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 471854012192 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854012193 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854012194 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854012195 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854012196 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854012197 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854012198 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471854012199 Sulfatase; Region: Sulfatase; pfam00884 471854012200 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 471854012201 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 471854012202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854012203 non-specific DNA binding site [nucleotide binding]; other site 471854012204 salt bridge; other site 471854012205 sequence-specific DNA binding site [nucleotide binding]; other site 471854012206 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471854012207 Sulfatase; Region: Sulfatase; pfam00884 471854012208 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854012209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854012210 active site 471854012211 phosphorylation site [posttranslational modification] 471854012212 intermolecular recognition site; other site 471854012213 dimerization interface [polypeptide binding]; other site 471854012214 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854012215 DNA binding residues [nucleotide binding] 471854012216 dimerization interface [polypeptide binding]; other site 471854012217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854012218 TPR motif; other site 471854012219 binding surface 471854012220 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854012221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854012222 binding surface 471854012223 TPR motif; other site 471854012224 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854012225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854012226 binding surface 471854012227 TPR motif; other site 471854012228 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471854012229 Histidine kinase; Region: HisKA_3; pfam07730 471854012230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854012231 ATP binding site [chemical binding]; other site 471854012232 Mg2+ binding site [ion binding]; other site 471854012233 G-X-G motif; other site 471854012234 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 471854012235 MAEBL; Provisional; Region: PTZ00121 471854012236 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 471854012237 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 471854012238 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471854012239 Peptidase family M23; Region: Peptidase_M23; pfam01551 471854012240 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 471854012241 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 471854012242 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 471854012243 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 471854012244 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 471854012245 conserved cys residue [active] 471854012246 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854012247 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 471854012248 Ca binding site [ion binding]; other site 471854012249 ligand binding site I [chemical binding]; other site 471854012250 homodimer interface [polypeptide binding]; other site 471854012251 ligand binding site II [chemical binding]; other site 471854012252 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 471854012253 Ca binding site [ion binding]; other site 471854012254 ligand binding site I [chemical binding]; other site 471854012255 homodimer interface [polypeptide binding]; other site 471854012256 ligand binding site II [chemical binding]; other site 471854012257 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 471854012258 Ca binding site [ion binding]; other site 471854012259 ligand binding site I [chemical binding]; other site 471854012260 homodimer interface [polypeptide binding]; other site 471854012261 ligand binding site II [chemical binding]; other site 471854012262 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 471854012263 Ca binding site [ion binding]; other site 471854012264 ligand binding site I [chemical binding]; other site 471854012265 homodimer interface [polypeptide binding]; other site 471854012266 ligand binding site II [chemical binding]; other site 471854012267 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854012268 Short C-terminal domain; Region: SHOCT; pfam09851 471854012269 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 471854012270 Mechanosensitive ion channel; Region: MS_channel; pfam00924 471854012271 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 471854012272 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 471854012273 homotetramer interface [polypeptide binding]; other site 471854012274 ligand binding site [chemical binding]; other site 471854012275 catalytic site [active] 471854012276 NAD binding site [chemical binding]; other site 471854012277 Histidine kinase; Region: His_kinase; pfam06580 471854012278 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854012279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854012280 active site 471854012281 phosphorylation site [posttranslational modification] 471854012282 intermolecular recognition site; other site 471854012283 dimerization interface [polypeptide binding]; other site 471854012284 LytTr DNA-binding domain; Region: LytTR; smart00850 471854012285 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 471854012286 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 471854012287 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 471854012288 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 471854012289 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 471854012290 dimer interface [polypeptide binding]; other site 471854012291 decamer (pentamer of dimers) interface [polypeptide binding]; other site 471854012292 catalytic triad [active] 471854012293 peroxidatic and resolving cysteines [active] 471854012294 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 471854012295 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471854012296 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471854012297 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471854012298 FG-GAP repeat; Region: FG-GAP; pfam01839 471854012299 Family description; Region: VCBS; pfam13517 471854012300 FG-GAP repeat; Region: FG-GAP; pfam01839 471854012301 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854012302 rhamnose-proton symporter; Provisional; Region: PRK13499 471854012303 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 471854012304 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 471854012305 trimer interface [polypeptide binding]; other site 471854012306 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 471854012307 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854012308 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 471854012309 Cytochrome c; Region: Cytochrom_C; pfam00034 471854012310 Family description; Region: VCBS; pfam13517 471854012311 Family description; Region: VCBS; pfam13517 471854012312 Family description; Region: VCBS; pfam13517 471854012313 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471854012314 malate:quinone oxidoreductase; Validated; Region: PRK05257 471854012315 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 471854012316 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 471854012317 active site 471854012318 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854012319 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 471854012320 active site 471854012321 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 471854012322 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 471854012323 Ligand Binding Site [chemical binding]; other site 471854012324 Molecular Tunnel; other site 471854012325 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 471854012326 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 471854012327 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 471854012328 ATP-binding site [chemical binding]; other site 471854012329 Sugar specificity; other site 471854012330 Pyrimidine base specificity; other site 471854012331 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854012332 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 471854012333 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 471854012334 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 471854012335 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 471854012336 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471854012337 FG-GAP repeat; Region: FG-GAP; pfam01839 471854012338 Family description; Region: VCBS; pfam13517 471854012339 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 471854012340 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 471854012341 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 471854012342 active site 471854012343 nucleotide binding site [chemical binding]; other site 471854012344 HIGH motif; other site 471854012345 KMSKS motif; other site 471854012346 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 471854012347 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 471854012348 tetramerization interface [polypeptide binding]; other site 471854012349 active site 471854012350 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854012351 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854012352 pantoate--beta-alanine ligase; Region: panC; TIGR00018 471854012353 Pantoate-beta-alanine ligase; Region: PanC; cd00560 471854012354 active site 471854012355 ATP-binding site [chemical binding]; other site 471854012356 pantoate-binding site; other site 471854012357 HXXH motif; other site 471854012358 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 471854012359 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 471854012360 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 471854012361 glutaminase active site [active] 471854012362 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471854012363 dimer interface [polypeptide binding]; other site 471854012364 active site 471854012365 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471854012366 dimer interface [polypeptide binding]; other site 471854012367 active site 471854012368 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 471854012369 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471854012370 classical (c) SDRs; Region: SDR_c; cd05233 471854012371 NAD(P) binding site [chemical binding]; other site 471854012372 active site 471854012373 dihydroxy-acid dehydratase; Validated; Region: PRK06131 471854012374 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 471854012375 MerC mercury resistance protein; Region: MerC; pfam03203 471854012376 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 471854012377 metal binding site 2 [ion binding]; metal-binding site 471854012378 putative DNA binding helix; other site 471854012379 metal binding site 1 [ion binding]; metal-binding site 471854012380 dimer interface [polypeptide binding]; other site 471854012381 structural Zn2+ binding site [ion binding]; other site 471854012382 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854012383 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854012384 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 471854012385 N-terminal plug; other site 471854012386 ligand-binding site [chemical binding]; other site 471854012387 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 471854012388 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 471854012389 putative substrate binding site [chemical binding]; other site 471854012390 putative ATP binding site [chemical binding]; other site 471854012391 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 471854012392 classical (c) SDRs; Region: SDR_c; cd05233 471854012393 NAD(P) binding site [chemical binding]; other site 471854012394 active site 471854012395 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 471854012396 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 471854012397 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854012398 Walker A motif; other site 471854012399 ATP binding site [chemical binding]; other site 471854012400 Walker B motif; other site 471854012401 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 471854012402 Clp protease; Region: CLP_protease; pfam00574 471854012403 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471854012404 oligomer interface [polypeptide binding]; other site 471854012405 active site residues [active] 471854012406 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471854012407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854012408 non-specific DNA binding site [nucleotide binding]; other site 471854012409 salt bridge; other site 471854012410 sequence-specific DNA binding site [nucleotide binding]; other site 471854012411 trigger factor; Region: tig; TIGR00115 471854012412 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 471854012413 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471854012414 Zn2+ binding site [ion binding]; other site 471854012415 Mg2+ binding site [ion binding]; other site 471854012416 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 471854012417 synthetase active site [active] 471854012418 NTP binding site [chemical binding]; other site 471854012419 metal binding site [ion binding]; metal-binding site 471854012420 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 471854012421 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 471854012422 ferric uptake regulator; Provisional; Region: fur; PRK09462 471854012423 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471854012424 metal binding site 2 [ion binding]; metal-binding site 471854012425 putative DNA binding helix; other site 471854012426 metal binding site 1 [ion binding]; metal-binding site 471854012427 dimer interface [polypeptide binding]; other site 471854012428 structural Zn2+ binding site [ion binding]; other site 471854012429 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 471854012430 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 471854012431 GDP-binding site [chemical binding]; other site 471854012432 ACT binding site; other site 471854012433 IMP binding site; other site 471854012434 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 471854012435 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471854012436 ATP binding site [chemical binding]; other site 471854012437 putative Mg++ binding site [ion binding]; other site 471854012438 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854012439 nucleotide binding region [chemical binding]; other site 471854012440 ATP-binding site [chemical binding]; other site 471854012441 Integral membrane protein TerC family; Region: TerC; cl10468 471854012442 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 471854012443 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 471854012444 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 471854012445 AAA domain; Region: AAA_12; pfam13087 471854012446 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854012447 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 471854012448 nucleotide binding site/active site [active] 471854012449 HIT family signature motif; other site 471854012450 catalytic residue [active] 471854012451 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 471854012452 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 471854012453 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 471854012454 Bacterial sugar transferase; Region: Bac_transf; pfam02397 471854012455 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471854012456 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 471854012457 putative NAD(P) binding site [chemical binding]; other site 471854012458 active site 471854012459 putative substrate binding site [chemical binding]; other site 471854012460 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 471854012461 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854012462 putative ADP-binding pocket [chemical binding]; other site 471854012463 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 471854012464 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854012465 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 471854012466 putative ADP-binding pocket [chemical binding]; other site 471854012467 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854012468 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 471854012469 metal-binding site 471854012470 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854012471 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471854012472 active site 471854012473 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 471854012474 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 471854012475 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471854012476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854012477 NAD(P) binding site [chemical binding]; other site 471854012478 active site 471854012479 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 471854012480 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471854012481 inhibitor-cofactor binding pocket; inhibition site 471854012482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854012483 catalytic residue [active] 471854012484 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471854012485 extended (e) SDRs; Region: SDR_e; cd08946 471854012486 NAD(P) binding site [chemical binding]; other site 471854012487 active site 471854012488 substrate binding site [chemical binding]; other site 471854012489 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 471854012490 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 471854012491 NAD binding site [chemical binding]; other site 471854012492 homotetramer interface [polypeptide binding]; other site 471854012493 homodimer interface [polypeptide binding]; other site 471854012494 substrate binding site [chemical binding]; other site 471854012495 active site 471854012496 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 471854012497 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 471854012498 substrate binding site; other site 471854012499 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 471854012500 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 471854012501 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 471854012502 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 471854012503 SLBB domain; Region: SLBB; pfam10531 471854012504 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 471854012505 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 471854012506 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 471854012507 dimer interface [polypeptide binding]; other site 471854012508 anticodon binding site; other site 471854012509 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 471854012510 homodimer interface [polypeptide binding]; other site 471854012511 motif 1; other site 471854012512 active site 471854012513 motif 2; other site 471854012514 GAD domain; Region: GAD; pfam02938 471854012515 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471854012516 active site 471854012517 motif 3; other site 471854012518 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 471854012519 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854012520 Leucine rich repeat N-terminal domain; Region: LRRNT_2; pfam08263 471854012521 Leucine rich repeat; Region: LRR_8; pfam13855 471854012522 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854012523 short chain dehydrogenase; Validated; Region: PRK08324 471854012524 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 471854012525 active site 471854012526 Zn2+ binding site [ion binding]; other site 471854012527 intersubunit interface [polypeptide binding]; other site 471854012528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854012529 NAD(P) binding site [chemical binding]; other site 471854012530 active site 471854012531 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 471854012532 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 471854012533 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471854012534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471854012535 DNA-binding site [nucleotide binding]; DNA binding site 471854012536 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 471854012537 putative dimerization interface [polypeptide binding]; other site 471854012538 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471854012539 putative ligand binding site [chemical binding]; other site 471854012540 hypothetical protein; Provisional; Region: PRK09256 471854012541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854012542 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471854012543 putative substrate translocation pore; other site 471854012544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 471854012545 Protein of unknown function (DUF433); Region: DUF433; pfam04255 471854012546 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 471854012547 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471854012548 HEAT repeats; Region: HEAT_2; pfam13646 471854012549 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 471854012550 protein binding surface [polypeptide binding]; other site 471854012551 HEAT repeats; Region: HEAT_2; pfam13646 471854012552 HEAT repeats; Region: HEAT_2; pfam13646 471854012553 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 471854012554 Cytochrome c; Region: Cytochrom_C; pfam00034 471854012555 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471854012556 putative active site [active] 471854012557 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471854012558 Domain of unknown function DUF21; Region: DUF21; pfam01595 471854012559 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471854012560 Transporter associated domain; Region: CorC_HlyC; pfam03471 471854012561 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471854012562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854012563 NAD(P) binding site [chemical binding]; other site 471854012564 active site 471854012565 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 471854012566 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 471854012567 active site 471854012568 tetramer interface; other site 471854012569 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 471854012570 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 471854012571 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 471854012572 Uncharacterized conserved protein [Function unknown]; Region: COG2353 471854012573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 471854012574 Protein of unknown function (DUF433); Region: DUF433; pfam04255 471854012575 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 471854012576 core domain interface [polypeptide binding]; other site 471854012577 delta subunit interface [polypeptide binding]; other site 471854012578 epsilon subunit interface [polypeptide binding]; other site 471854012579 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 471854012580 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471854012581 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 471854012582 beta subunit interaction interface [polypeptide binding]; other site 471854012583 Walker A motif; other site 471854012584 ATP binding site [chemical binding]; other site 471854012585 Walker B motif; other site 471854012586 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471854012587 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 471854012588 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 471854012589 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471854012590 carboxy-terminal protease; Provisional; Region: PRK11186 471854012591 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 471854012592 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 471854012593 protein binding site [polypeptide binding]; other site 471854012594 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 471854012595 Catalytic dyad [active] 471854012596 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 471854012597 Thioredoxin; Region: Thioredoxin_4; pfam13462 471854012598 CopC domain; Region: CopC; cl01012 471854012599 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 471854012600 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 471854012601 Protein export membrane protein; Region: SecD_SecF; cl14618 471854012602 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854012603 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471854012604 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854012605 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471854012606 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471854012607 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 471854012608 putative hydrophobic ligand binding site [chemical binding]; other site 471854012609 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 471854012610 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 471854012611 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 471854012612 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 471854012613 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 471854012614 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 471854012615 N-terminal plug; other site 471854012616 ligand-binding site [chemical binding]; other site 471854012617 YceI-like domain; Region: YceI; pfam04264 471854012618 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 471854012619 putative dimer interface [polypeptide binding]; other site 471854012620 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854012621 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854012622 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854012623 Cupin-like domain; Region: Cupin_8; pfam13621 471854012624 excinuclease ABC subunit B; Provisional; Region: PRK05298 471854012625 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471854012626 ATP binding site [chemical binding]; other site 471854012627 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854012628 nucleotide binding region [chemical binding]; other site 471854012629 ATP-binding site [chemical binding]; other site 471854012630 Ultra-violet resistance protein B; Region: UvrB; pfam12344 471854012631 UvrB/uvrC motif; Region: UVR; pfam02151 471854012632 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 471854012633 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 471854012634 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471854012635 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 471854012636 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 471854012637 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 471854012638 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 471854012639 NAD binding site [chemical binding]; other site 471854012640 homodimer interface [polypeptide binding]; other site 471854012641 homotetramer interface [polypeptide binding]; other site 471854012642 active site 471854012643 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 471854012644 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471854012645 active site 471854012646 HIGH motif; other site 471854012647 nucleotide binding site [chemical binding]; other site 471854012648 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471854012649 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471854012650 active site 471854012651 KMSKS motif; other site 471854012652 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 471854012653 tRNA binding surface [nucleotide binding]; other site 471854012654 anticodon binding site; other site 471854012655 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 471854012656 active site clefts [active] 471854012657 zinc binding site [ion binding]; other site 471854012658 dimer interface [polypeptide binding]; other site 471854012659 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 471854012660 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 471854012661 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 471854012662 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 471854012663 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 471854012664 active site 471854012665 catalytic residues [active] 471854012666 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 471854012667 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 471854012668 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 471854012669 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 471854012670 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471854012671 short chain dehydrogenase; Provisional; Region: PRK06057 471854012672 classical (c) SDRs; Region: SDR_c; cd05233 471854012673 NAD(P) binding site [chemical binding]; other site 471854012674 active site 471854012675 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471854012676 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 471854012677 NAD(P) binding site [chemical binding]; other site 471854012678 catalytic residues [active] 471854012679 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471854012680 putative active site [active] 471854012681 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 471854012682 catalytic triad [active] 471854012683 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 471854012684 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471854012685 active site 471854012686 K+ potassium transporter; Region: K_trans; pfam02705 471854012687 manganese transport protein MntH; Reviewed; Region: PRK00701 471854012688 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 471854012689 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 471854012690 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 471854012691 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 471854012692 FeoA domain; Region: FeoA; pfam04023 471854012693 Predicted permeases [General function prediction only]; Region: COG0795 471854012694 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 471854012695 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 471854012696 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 471854012697 Ligand binding site; other site 471854012698 Putative Catalytic site; other site 471854012699 DXD motif; other site 471854012700 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 471854012701 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 471854012702 Ligand binding site; other site 471854012703 Putative Catalytic site; other site 471854012704 DXD motif; other site 471854012705 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 471854012706 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 471854012707 oligomerisation interface [polypeptide binding]; other site 471854012708 mobile loop; other site 471854012709 roof hairpin; other site 471854012710 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471854012711 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471854012712 active site 471854012713 catalytic tetrad [active] 471854012714 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 471854012715 NodB motif; other site 471854012716 putative active site [active] 471854012717 putative catalytic site [active] 471854012718 putative Zn binding site [ion binding]; other site 471854012719 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 471854012720 DNA-binding site [nucleotide binding]; DNA binding site 471854012721 RNA-binding motif; other site 471854012722 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 471854012723 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 471854012724 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 471854012725 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 471854012726 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 471854012727 ligand binding site [chemical binding]; other site 471854012728 NAD binding site [chemical binding]; other site 471854012729 tetramer interface [polypeptide binding]; other site 471854012730 catalytic site [active] 471854012731 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 471854012732 L-serine binding site [chemical binding]; other site 471854012733 ACT domain interface; other site 471854012734 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471854012735 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471854012736 catalytic residue [active] 471854012737 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 471854012738 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 471854012739 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854012740 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854012741 DNA binding residues [nucleotide binding] 471854012742 FecR protein; Region: FecR; pfam04773 471854012743 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854012744 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854012745 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854012746 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854012747 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854012748 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854012749 SusD family; Region: SusD; pfam07980 471854012750 Protein of unknown function (DUF3823); Region: DUF3823; pfam12866 471854012751 Trehalose utilisation; Region: ThuA; pfam06283 471854012752 conserved cys residue [active] 471854012753 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 471854012754 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 471854012755 Trehalose utilisation; Region: ThuA; pfam06283 471854012756 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854012757 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854012758 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471854012759 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471854012760 Metal-binding active site; metal-binding site 471854012761 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 471854012762 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 471854012763 putative substrate binding site [chemical binding]; other site 471854012764 active site 471854012765 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 471854012766 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854012767 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854012768 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854012769 DNA binding residues [nucleotide binding] 471854012770 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854012771 FecR protein; Region: FecR; pfam04773 471854012772 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854012773 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854012774 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854012775 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854012776 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854012777 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854012778 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854012779 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471854012780 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 471854012781 putative metal binding site [ion binding]; other site 471854012782 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471854012783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854012784 putative substrate translocation pore; other site 471854012785 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471854012786 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 471854012787 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 471854012788 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471854012789 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854012790 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854012791 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854012792 DNA binding residues [nucleotide binding] 471854012793 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854012794 FecR protein; Region: FecR; pfam04773 471854012795 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854012796 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854012797 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854012798 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854012799 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854012800 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854012801 Phytase; Region: Phytase; cl17685 471854012802 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854012803 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 471854012804 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 471854012805 N-terminal plug; other site 471854012806 ligand-binding site [chemical binding]; other site 471854012807 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854012808 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854012809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854012810 TPR motif; other site 471854012811 binding surface 471854012812 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854012813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854012814 binding surface 471854012815 TPR motif; other site 471854012816 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854012817 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 471854012818 xylose isomerase; Provisional; Region: PRK05474 471854012819 xylose isomerase; Region: xylose_isom_A; TIGR02630 471854012820 SurA N-terminal domain; Region: SurA_N_3; cl07813 471854012821 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 471854012822 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 471854012823 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 471854012824 SCP-2 sterol transfer family; Region: SCP2; pfam02036 471854012825 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854012826 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854012827 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 471854012828 active site 471854012829 hydrophilic channel; other site 471854012830 dimerization interface [polypeptide binding]; other site 471854012831 catalytic residues [active] 471854012832 active site lid [active] 471854012833 Yqey-like protein; Region: YqeY; pfam09424 471854012834 Colicin V production protein; Region: Colicin_V; pfam02674 471854012835 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 471854012836 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471854012837 FeS/SAM binding site; other site 471854012838 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 471854012839 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 471854012840 quinolinate synthetase; Provisional; Region: PRK09375 471854012841 L-aspartate oxidase; Provisional; Region: PRK09077 471854012842 L-aspartate oxidase; Provisional; Region: PRK06175 471854012843 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471854012844 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 471854012845 active site 471854012846 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854012847 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854012848 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854012849 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854012850 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854012851 SusD family; Region: SusD; pfam07980 471854012852 Family description; Region: VCBS; pfam13517 471854012853 Family description; Region: VCBS; pfam13517 471854012854 Family description; Region: VCBS; pfam13517 471854012855 Family description; Region: VCBS; pfam13517 471854012856 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 471854012857 Family description; Region: VCBS; pfam13517 471854012858 Family description; Region: VCBS; pfam13517 471854012859 Family description; Region: VCBS; pfam13517 471854012860 Family description; Region: VCBS; pfam13517 471854012861 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 471854012862 active site 471854012863 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 471854012864 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 471854012865 active site 471854012866 nucleophile elbow; other site 471854012867 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 471854012868 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 471854012869 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 471854012870 FAD dependent oxidoreductase; Region: DAO; pfam01266 471854012871 TrkA-N domain; Region: TrkA_N; pfam02254 471854012872 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 471854012873 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 471854012874 tetramer interface [polypeptide binding]; other site 471854012875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854012876 catalytic residue [active] 471854012877 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 471854012878 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 471854012879 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854012880 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854012881 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854012882 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 471854012883 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 471854012884 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854012885 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854012886 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471854012887 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 471854012888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854012889 putative sialic acid transporter; Provisional; Region: PRK12307 471854012890 putative substrate translocation pore; other site 471854012891 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 471854012892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854012893 NAD(P) binding site [chemical binding]; other site 471854012894 active site 471854012895 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854012896 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854012897 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471854012898 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471854012899 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 471854012900 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471854012901 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854012902 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471854012903 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471854012904 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 471854012905 Walker A/P-loop; other site 471854012906 ATP binding site [chemical binding]; other site 471854012907 Q-loop/lid; other site 471854012908 ABC transporter signature motif; other site 471854012909 Walker B; other site 471854012910 D-loop; other site 471854012911 H-loop/switch region; other site 471854012912 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 471854012913 Transglycosylase; Region: Transgly; pfam00912 471854012914 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 471854012915 methionine sulfoxide reductase B; Provisional; Region: PRK00222 471854012916 SelR domain; Region: SelR; pfam01641 471854012917 Uncharacterized conserved protein [Function unknown]; Region: COG2308 471854012918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 471854012919 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 471854012920 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 471854012921 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 471854012922 dimer interface [polypeptide binding]; other site 471854012923 motif 1; other site 471854012924 active site 471854012925 motif 2; other site 471854012926 motif 3; other site 471854012927 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854012928 LytTr DNA-binding domain; Region: LytTR; smart00850 471854012929 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 471854012930 DNA repair protein RadA; Provisional; Region: PRK11823 471854012931 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 471854012932 Walker A motif/ATP binding site; other site 471854012933 ATP binding site [chemical binding]; other site 471854012934 Walker B motif; other site 471854012935 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 471854012936 Protein of unknown function DUF58; Region: DUF58; pfam01882 471854012937 von Willebrand factor type A domain; Region: VWA_2; pfam13519 471854012938 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 471854012939 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 471854012940 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 471854012941 GTP-binding protein YchF; Reviewed; Region: PRK09601 471854012942 YchF GTPase; Region: YchF; cd01900 471854012943 G1 box; other site 471854012944 GTP/Mg2+ binding site [chemical binding]; other site 471854012945 Switch I region; other site 471854012946 G2 box; other site 471854012947 Switch II region; other site 471854012948 G3 box; other site 471854012949 G4 box; other site 471854012950 G5 box; other site 471854012951 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 471854012952 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471854012953 putative active site [active] 471854012954 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471854012955 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471854012956 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471854012957 ABC transporter; Region: ABC_tran_2; pfam12848 471854012958 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471854012959 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 471854012960 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 471854012961 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854012962 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854012963 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 471854012964 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 471854012965 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854012966 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854012967 Domain of unknown function (DUF4302); Region: DUF4302; pfam14135 471854012968 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 471854012969 metal-binding site 471854012970 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 471854012971 putative glycosyl transferase; Provisional; Region: PRK10125 471854012972 Methyltransferase domain; Region: Methyltransf_11; pfam08241 471854012973 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 471854012974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854012975 NAD(P) binding site [chemical binding]; other site 471854012976 active site 471854012977 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471854012978 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 471854012979 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 471854012980 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471854012981 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854012982 active site 471854012983 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 471854012984 active site 471854012985 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 471854012986 homodimer interface [polypeptide binding]; other site 471854012987 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 471854012988 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 471854012989 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 471854012990 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 471854012991 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 471854012992 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854012993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854012994 active site 471854012995 phosphorylation site [posttranslational modification] 471854012996 intermolecular recognition site; other site 471854012997 dimerization interface [polypeptide binding]; other site 471854012998 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854012999 DNA binding residues [nucleotide binding] 471854013000 dimerization interface [polypeptide binding]; other site 471854013001 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471854013002 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 471854013003 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 471854013004 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854013005 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471854013006 active site 471854013007 DinB family; Region: DinB; cl17821 471854013008 DinB superfamily; Region: DinB_2; pfam12867 471854013009 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471854013010 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471854013011 active site 471854013012 metal binding site [ion binding]; metal-binding site 471854013013 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 471854013014 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 471854013015 N- and C-terminal domain interface [polypeptide binding]; other site 471854013016 active site 471854013017 catalytic site [active] 471854013018 metal binding site [ion binding]; metal-binding site 471854013019 carbohydrate binding site [chemical binding]; other site 471854013020 ATP binding site [chemical binding]; other site 471854013021 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854013022 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 471854013023 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 471854013024 N-terminal plug; other site 471854013025 ligand-binding site [chemical binding]; other site 471854013026 Cytochrome c; Region: Cytochrom_C; pfam00034 471854013027 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471854013028 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 471854013029 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 471854013030 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 471854013031 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 471854013032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854013033 Walker A motif; other site 471854013034 ATP binding site [chemical binding]; other site 471854013035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854013036 Walker B motif; other site 471854013037 arginine finger; other site 471854013038 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 471854013039 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 471854013040 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471854013041 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 471854013042 folate binding site [chemical binding]; other site 471854013043 NADP+ binding site [chemical binding]; other site 471854013044 Transposase IS200 like; Region: Y1_Tnp; pfam01797 471854013045 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 471854013046 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 471854013047 putative active site [active] 471854013048 substrate binding site [chemical binding]; other site 471854013049 putative cosubstrate binding site; other site 471854013050 catalytic site [active] 471854013051 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 471854013052 substrate binding site [chemical binding]; other site 471854013053 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 471854013054 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 471854013055 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 471854013056 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 471854013057 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 471854013058 oligomer interface [polypeptide binding]; other site 471854013059 active site 471854013060 metal binding site [ion binding]; metal-binding site 471854013061 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 471854013062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471854013063 FeS/SAM binding site; other site 471854013064 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 471854013065 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854013066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854013067 active site 471854013068 phosphorylation site [posttranslational modification] 471854013069 intermolecular recognition site; other site 471854013070 dimerization interface [polypeptide binding]; other site 471854013071 LytTr DNA-binding domain; Region: LytTR; smart00850 471854013072 ethanolamine permease; Region: 2A0305; TIGR00908 471854013073 hypothetical protein; Provisional; Region: PHA02764 471854013074 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 471854013075 putative active site [active] 471854013076 catalytic site [active] 471854013077 amino acid transporter; Region: 2A0306; TIGR00909 471854013078 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 471854013079 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471854013080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854013081 ATP binding site [chemical binding]; other site 471854013082 Mg2+ binding site [ion binding]; other site 471854013083 G-X-G motif; other site 471854013084 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 471854013085 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 471854013086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471854013087 motif II; other site 471854013088 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 471854013089 substrate binding site [chemical binding]; other site 471854013090 multimerization interface [polypeptide binding]; other site 471854013091 ATP binding site [chemical binding]; other site 471854013092 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 471854013093 thiamine phosphate binding site [chemical binding]; other site 471854013094 active site 471854013095 pyrophosphate binding site [ion binding]; other site 471854013096 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 471854013097 dimer interface [polypeptide binding]; other site 471854013098 substrate binding site [chemical binding]; other site 471854013099 ATP binding site [chemical binding]; other site 471854013100 Putative transcription activator [Transcription]; Region: TenA; COG0819 471854013101 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854013102 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854013103 2TM domain; Region: 2TM; pfam13239 471854013104 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 471854013105 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 471854013106 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 471854013107 dimerization interface [polypeptide binding]; other site 471854013108 metal binding site [ion binding]; metal-binding site 471854013109 Late embryogenesis abundant protein; Region: LEA_2; cl12118 471854013110 Late embryogenesis abundant protein; Region: LEA_2; cl12118 471854013111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 471854013112 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 471854013113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854013114 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 471854013115 active site 471854013116 phosphorylation site [posttranslational modification] 471854013117 intermolecular recognition site; other site 471854013118 dimerization interface [polypeptide binding]; other site 471854013119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854013120 Walker A motif; other site 471854013121 ATP binding site [chemical binding]; other site 471854013122 Walker B motif; other site 471854013123 arginine finger; other site 471854013124 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 471854013125 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854013126 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854013127 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471854013128 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471854013129 Walker A/P-loop; other site 471854013130 ATP binding site [chemical binding]; other site 471854013131 Q-loop/lid; other site 471854013132 ABC transporter signature motif; other site 471854013133 Walker B; other site 471854013134 D-loop; other site 471854013135 H-loop/switch region; other site 471854013136 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 471854013137 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013138 FtsX-like permease family; Region: FtsX; pfam02687 471854013139 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013140 FtsX-like permease family; Region: FtsX; pfam02687 471854013141 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 471854013142 putative active site [active] 471854013143 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013144 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471854013145 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 471854013146 FtsX-like permease family; Region: FtsX; pfam02687 471854013147 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013148 FtsX-like permease family; Region: FtsX; pfam02687 471854013149 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013150 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471854013151 FtsX-like permease family; Region: FtsX; pfam02687 471854013152 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471854013153 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013154 FtsX-like permease family; Region: FtsX; pfam02687 471854013155 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 471854013156 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013157 FtsX-like permease family; Region: FtsX; pfam02687 471854013158 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471854013159 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013160 FtsX-like permease family; Region: FtsX; pfam02687 471854013161 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 471854013162 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013163 FtsX-like permease family; Region: FtsX; pfam02687 471854013164 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013165 FtsX-like permease family; Region: FtsX; pfam02687 471854013166 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 471854013167 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013168 FtsX-like permease family; Region: FtsX; pfam02687 471854013169 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013170 FtsX-like permease family; Region: FtsX; pfam02687 471854013171 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 471854013172 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013173 FtsX-like permease family; Region: FtsX; pfam02687 471854013174 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013175 FtsX-like permease family; Region: FtsX; pfam02687 471854013176 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 471854013177 putative active site [active] 471854013178 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 471854013179 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854013180 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854013181 DNA binding residues [nucleotide binding] 471854013182 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854013183 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854013184 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854013185 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 471854013186 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013187 FtsX-like permease family; Region: FtsX; pfam02687 471854013188 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013189 FtsX-like permease family; Region: FtsX; pfam02687 471854013190 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013191 FtsX-like permease family; Region: FtsX; pfam02687 471854013192 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013193 FtsX-like permease family; Region: FtsX; pfam02687 471854013194 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 471854013195 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013196 FtsX-like permease family; Region: FtsX; pfam02687 471854013197 FtsX-like permease family; Region: FtsX; pfam02687 471854013198 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 471854013199 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 471854013200 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013201 FtsX-like permease family; Region: FtsX; pfam02687 471854013202 FtsX-like permease family; Region: FtsX; pfam02687 471854013203 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 471854013204 putative ligand binding site [chemical binding]; other site 471854013205 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 471854013206 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854013207 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854013208 DNA binding residues [nucleotide binding] 471854013209 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854013210 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 471854013211 beta-galactosidase; Region: BGL; TIGR03356 471854013212 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 471854013213 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 471854013214 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 471854013215 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 471854013216 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 471854013217 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 471854013218 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 471854013219 Ribosome-binding factor A; Region: RBFA; pfam02033 471854013220 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 471854013221 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013222 FtsX-like permease family; Region: FtsX; pfam02687 471854013223 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 471854013224 Zn binding site [ion binding]; other site 471854013225 HEAT repeats; Region: HEAT_2; pfam13646 471854013226 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471854013227 DNA binding site [nucleotide binding] 471854013228 domain linker motif; other site 471854013229 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 471854013230 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 471854013231 ligand binding site [chemical binding]; other site 471854013232 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 471854013233 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 471854013234 FAD binding pocket [chemical binding]; other site 471854013235 FAD binding motif [chemical binding]; other site 471854013236 phosphate binding motif [ion binding]; other site 471854013237 beta-alpha-beta structure motif; other site 471854013238 NAD(p) ribose binding residues [chemical binding]; other site 471854013239 NAD binding pocket [chemical binding]; other site 471854013240 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 471854013241 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471854013242 catalytic loop [active] 471854013243 iron binding site [ion binding]; other site 471854013244 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 471854013245 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 471854013246 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 471854013247 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 471854013248 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 471854013249 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 471854013250 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471854013251 putative catalytic residue [active] 471854013252 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 471854013253 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 471854013254 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 471854013255 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 471854013256 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471854013257 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 471854013258 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 471854013259 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 471854013260 generic binding surface II; other site 471854013261 ssDNA binding site; other site 471854013262 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471854013263 ATP binding site [chemical binding]; other site 471854013264 putative Mg++ binding site [ion binding]; other site 471854013265 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854013266 nucleotide binding region [chemical binding]; other site 471854013267 ATP-binding site [chemical binding]; other site 471854013268 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471854013269 L-fuculokinase; Region: fuculo_kin_coli; TIGR02628 471854013270 nucleotide binding site [chemical binding]; other site 471854013271 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471854013272 active site 471854013273 catalytic triad [active] 471854013274 oxyanion hole [active] 471854013275 Outer membrane efflux protein; Region: OEP; pfam02321 471854013276 Outer membrane efflux protein; Region: OEP; pfam02321 471854013277 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471854013278 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471854013279 Walker A/P-loop; other site 471854013280 ATP binding site [chemical binding]; other site 471854013281 Q-loop/lid; other site 471854013282 ABC transporter signature motif; other site 471854013283 Walker B; other site 471854013284 D-loop; other site 471854013285 H-loop/switch region; other site 471854013286 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013287 FtsX-like permease family; Region: FtsX; pfam02687 471854013288 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013289 FtsX-like permease family; Region: FtsX; pfam02687 471854013290 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471854013291 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471854013292 DNA binding site [nucleotide binding] 471854013293 H+ Antiporter protein; Region: 2A0121; TIGR00900 471854013294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854013295 putative substrate translocation pore; other site 471854013296 PIN domain; Region: PIN_3; pfam13470 471854013297 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013298 FtsX-like permease family; Region: FtsX; pfam02687 471854013299 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854013300 FtsX-like permease family; Region: FtsX; pfam02687 471854013301 glycyl-tRNA synthetase; Provisional; Region: PRK04173 471854013302 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471854013303 motif 1; other site 471854013304 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 471854013305 active site 471854013306 motif 2; other site 471854013307 motif 3; other site 471854013308 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 471854013309 anticodon binding site; other site 471854013310 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471854013311 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854013312 non-specific DNA binding site [nucleotide binding]; other site 471854013313 salt bridge; other site 471854013314 sequence-specific DNA binding site [nucleotide binding]; other site 471854013315 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 471854013316 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854013317 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854013318 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 471854013319 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 471854013320 putative active site [active] 471854013321 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471854013322 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854013323 Walker A/P-loop; other site 471854013324 ATP binding site [chemical binding]; other site 471854013325 Q-loop/lid; other site 471854013326 ABC transporter signature motif; other site 471854013327 Walker B; other site 471854013328 D-loop; other site 471854013329 H-loop/switch region; other site 471854013330 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 471854013331 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 471854013332 active site 471854013333 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 471854013334 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471854013335 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471854013336 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471854013337 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471854013338 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471854013339 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 471854013340 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 471854013341 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 471854013342 active site 471854013343 PHP Thumb interface [polypeptide binding]; other site 471854013344 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 471854013345 generic binding surface I; other site 471854013346 generic binding surface II; other site 471854013347 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 471854013348 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 471854013349 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854013350 sequence-specific DNA binding site [nucleotide binding]; other site 471854013351 salt bridge; other site 471854013352 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 471854013353 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 471854013354 active site 471854013355 DNA binding site [nucleotide binding] 471854013356 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854013357 non-specific DNA binding site [nucleotide binding]; other site 471854013358 salt bridge; other site 471854013359 sequence-specific DNA binding site [nucleotide binding]; other site 471854013360 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 471854013361 Predicted transcriptional regulator [Transcription]; Region: COG2932 471854013362 Catalytic site [active] 471854013363 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471854013364 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471854013365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854013366 Walker A/P-loop; other site 471854013367 ATP binding site [chemical binding]; other site 471854013368 Q-loop/lid; other site 471854013369 ABC transporter signature motif; other site 471854013370 Walker B; other site 471854013371 D-loop; other site 471854013372 H-loop/switch region; other site 471854013373 transcription antitermination factor NusB; Region: nusB; TIGR01951 471854013374 YtxH-like protein; Region: YtxH; pfam12732 471854013375 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 471854013376 Preprotein translocase subunit; Region: YajC; pfam02699 471854013377 dephospho-CoA kinase; Region: TIGR00152 471854013378 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 471854013379 CoA-binding site [chemical binding]; other site 471854013380 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 471854013381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854013382 Walker A motif; other site 471854013383 ATP binding site [chemical binding]; other site 471854013384 Walker B motif; other site 471854013385 arginine finger; other site 471854013386 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 471854013387 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 471854013388 active site 471854013389 catalytic residues [active] 471854013390 GSCFA family; Region: GSCFA; pfam08885 471854013391 antiporter inner membrane protein; Provisional; Region: PRK11670 471854013392 Domain of unknown function DUF59; Region: DUF59; pfam01883 471854013393 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 471854013394 NifU-like domain; Region: NifU; cl00484 471854013395 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 471854013396 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471854013397 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471854013398 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471854013399 alpha-glucosidase; Provisional; Region: PRK10137 471854013400 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 471854013401 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 471854013402 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 471854013403 active site 471854013404 substrate binding site [chemical binding]; other site 471854013405 metal binding site [ion binding]; metal-binding site 471854013406 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 471854013407 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854013408 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854013409 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854013410 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854013411 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854013412 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854013413 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854013414 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854013415 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854013416 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854013417 SusD family; Region: SusD; pfam07980 471854013418 Family description; Region: VCBS; pfam13517 471854013419 Family description; Region: VCBS; pfam13517 471854013420 Family description; Region: VCBS; pfam13517 471854013421 Family description; Region: VCBS; pfam13517 471854013422 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 471854013423 Family description; Region: VCBS; pfam13517 471854013424 Family description; Region: VCBS; pfam13517 471854013425 Family description; Region: VCBS; pfam13517 471854013426 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854013427 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854013428 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854013429 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854013430 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854013431 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854013432 SusD family; Region: SusD; pfam07980 471854013433 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 471854013434 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 471854013435 putative dimer interface [polypeptide binding]; other site 471854013436 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854013437 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854013438 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854013439 DNA binding residues [nucleotide binding] 471854013440 putative oxidoreductase; Provisional; Region: PRK11579 471854013441 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854013442 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471854013443 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 471854013444 Trp docking motif [polypeptide binding]; other site 471854013445 putative active site [active] 471854013446 PQQ-like domain; Region: PQQ_2; pfam13360 471854013447 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471854013448 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854013449 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 471854013450 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854013451 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854013452 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 471854013453 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 471854013454 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 471854013455 hexamer interface [polypeptide binding]; other site 471854013456 ligand binding site [chemical binding]; other site 471854013457 putative active site [active] 471854013458 NAD(P) binding site [chemical binding]; other site 471854013459 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 471854013460 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 471854013461 Walker A/P-loop; other site 471854013462 ATP binding site [chemical binding]; other site 471854013463 Q-loop/lid; other site 471854013464 ABC transporter signature motif; other site 471854013465 Walker B; other site 471854013466 D-loop; other site 471854013467 H-loop/switch region; other site 471854013468 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 471854013469 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 471854013470 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 471854013471 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 471854013472 chaperone protein DnaJ; Provisional; Region: PRK14289 471854013473 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471854013474 HSP70 interaction site [polypeptide binding]; other site 471854013475 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 471854013476 substrate binding site [polypeptide binding]; other site 471854013477 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 471854013478 Zn binding sites [ion binding]; other site 471854013479 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 471854013480 dimer interface [polypeptide binding]; other site 471854013481 GrpE; Region: GrpE; pfam01025 471854013482 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 471854013483 dimer interface [polypeptide binding]; other site 471854013484 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 471854013485 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 471854013486 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 471854013487 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 471854013488 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854013489 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854013490 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854013491 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854013492 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 471854013493 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854013494 Family description; Region: VCBS; pfam13517 471854013495 Family description; Region: VCBS; pfam13517 471854013496 Family description; Region: VCBS; pfam13517 471854013497 Family description; Region: VCBS; pfam13517 471854013498 Family description; Region: VCBS; pfam13517 471854013499 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 471854013500 Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632 471854013501 Family description; Region: VCBS; pfam13517 471854013502 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 471854013503 PIN domain; Region: PIN_2; pfam10130 471854013504 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471854013505 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 471854013506 active site 471854013507 catalytic triad [active] 471854013508 oxyanion hole [active] 471854013509 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 471854013510 HEAT repeats; Region: HEAT_2; pfam13646 471854013511 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471854013512 Cytochrome c; Region: Cytochrom_C; pfam00034 471854013513 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 471854013514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854013515 ATP binding site [chemical binding]; other site 471854013516 Mg2+ binding site [ion binding]; other site 471854013517 G-X-G motif; other site 471854013518 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 471854013519 anchoring element; other site 471854013520 dimer interface [polypeptide binding]; other site 471854013521 ATP binding site [chemical binding]; other site 471854013522 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 471854013523 active site 471854013524 putative metal-binding site [ion binding]; other site 471854013525 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471854013526 polyphosphate kinase; Provisional; Region: PRK05443 471854013527 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 471854013528 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 471854013529 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 471854013530 putative domain interface [polypeptide binding]; other site 471854013531 putative active site [active] 471854013532 catalytic site [active] 471854013533 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 471854013534 putative domain interface [polypeptide binding]; other site 471854013535 putative active site [active] 471854013536 catalytic site [active] 471854013537 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 471854013538 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471854013539 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471854013540 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 471854013541 active site 471854013542 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471854013543 dimer interface [polypeptide binding]; other site 471854013544 substrate binding site [chemical binding]; other site 471854013545 catalytic residues [active] 471854013546 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 471854013547 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 471854013548 oligomer interface [polypeptide binding]; other site 471854013549 metal binding site [ion binding]; metal-binding site 471854013550 metal binding site [ion binding]; metal-binding site 471854013551 Cl binding site [ion binding]; other site 471854013552 aspartate ring; other site 471854013553 basic sphincter; other site 471854013554 putative hydrophobic gate; other site 471854013555 periplasmic entrance; other site 471854013556 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471854013557 Ligand Binding Site [chemical binding]; other site 471854013558 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471854013559 Ligand Binding Site [chemical binding]; other site 471854013560 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 471854013561 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 471854013562 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 471854013563 ArsC family; Region: ArsC; pfam03960 471854013564 putative catalytic residues [active] 471854013565 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 471854013566 acetyl-CoA synthetase; Provisional; Region: PRK00174 471854013567 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 471854013568 active site 471854013569 CoA binding site [chemical binding]; other site 471854013570 acyl-activating enzyme (AAE) consensus motif; other site 471854013571 AMP binding site [chemical binding]; other site 471854013572 acetate binding site [chemical binding]; other site 471854013573 metal-dependent hydrolase; Provisional; Region: PRK13291 471854013574 DinB superfamily; Region: DinB_2; pfam12867 471854013575 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 471854013576 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 471854013577 active site 471854013578 dimerization interface [polypeptide binding]; other site 471854013579 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 471854013580 Predicted methyltransferases [General function prediction only]; Region: COG0313 471854013581 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 471854013582 putative SAM binding site [chemical binding]; other site 471854013583 putative homodimer interface [polypeptide binding]; other site 471854013584 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 471854013585 aromatic arch; other site 471854013586 DCoH dimer interaction site [polypeptide binding]; other site 471854013587 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 471854013588 DCoH tetramer interaction site [polypeptide binding]; other site 471854013589 substrate binding site [chemical binding]; other site 471854013590 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 471854013591 thymidylate synthase; Reviewed; Region: thyA; PRK01827 471854013592 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 471854013593 dimerization interface [polypeptide binding]; other site 471854013594 active site 471854013595 Predicted membrane protein [Function unknown]; Region: COG2860 471854013596 UPF0126 domain; Region: UPF0126; pfam03458 471854013597 UPF0126 domain; Region: UPF0126; pfam03458 471854013598 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 471854013599 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854013600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854013601 TPR motif; other site 471854013602 binding surface 471854013603 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 471854013604 nudix motif; other site 471854013605 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471854013606 active site 471854013607 catalytic residues [active] 471854013608 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854013609 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 471854013610 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 471854013611 active site 471854013612 FMN binding site [chemical binding]; other site 471854013613 substrate binding site [chemical binding]; other site 471854013614 3Fe-4S cluster binding site [ion binding]; other site 471854013615 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 471854013616 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 471854013617 hinge; other site 471854013618 active site 471854013619 Protein of unknown function (DUF502); Region: DUF502; pfam04367 471854013620 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 471854013621 YceG-like family; Region: YceG; pfam02618 471854013622 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 471854013623 dimerization interface [polypeptide binding]; other site 471854013624 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 471854013625 active site 471854013626 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 471854013627 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471854013628 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471854013629 active site 471854013630 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 471854013631 WbqC-like protein family; Region: WbqC; pfam08889 471854013632 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 471854013633 Clp amino terminal domain; Region: Clp_N; pfam02861 471854013634 Clp amino terminal domain; Region: Clp_N; pfam02861 471854013635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854013636 Walker A motif; other site 471854013637 ATP binding site [chemical binding]; other site 471854013638 Walker B motif; other site 471854013639 arginine finger; other site 471854013640 UvrB/uvrC motif; Region: UVR; pfam02151 471854013641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854013642 Walker A motif; other site 471854013643 ATP binding site [chemical binding]; other site 471854013644 Walker B motif; other site 471854013645 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 471854013646 Predicted peptidase [General function prediction only]; Region: COG4099 471854013647 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854013648 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471854013649 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 471854013650 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 471854013651 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 471854013652 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 471854013653 ATP synthase A chain; Region: ATP-synt_A; cl00413 471854013654 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 471854013655 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 471854013656 TPR repeat; Region: TPR_11; pfam13414 471854013657 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 471854013658 Transglycosylase; Region: Transgly; pfam00912 471854013659 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 471854013660 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 471854013661 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 471854013662 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471854013663 GIY-YIG motif/motif A; other site 471854013664 active site 471854013665 catalytic site [active] 471854013666 putative DNA binding site [nucleotide binding]; other site 471854013667 metal binding site [ion binding]; metal-binding site 471854013668 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 471854013669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471854013670 flavoprotein, HI0933 family; Region: TIGR00275 471854013671 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 471854013672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854013673 aldehyde dehydrogenase family 7 member; Region: PLN02315 471854013674 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 471854013675 tetrameric interface [polypeptide binding]; other site 471854013676 NAD binding site [chemical binding]; other site 471854013677 catalytic residues [active] 471854013678 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 471854013679 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 471854013680 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 471854013681 active site 471854013682 metal-binding site [ion binding] 471854013683 nucleotide-binding site [chemical binding]; other site 471854013684 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 471854013685 active site 471854013686 catalytic residues [active] 471854013687 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 471854013688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854013689 Walker A motif; other site 471854013690 ATP binding site [chemical binding]; other site 471854013691 Walker B motif; other site 471854013692 arginine finger; other site 471854013693 Peptidase family M41; Region: Peptidase_M41; pfam01434 471854013694 Oligomerisation domain; Region: Oligomerisation; pfam02410 471854013695 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 471854013696 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 471854013697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854013698 TPR repeat; Region: TPR_11; pfam13414 471854013699 binding surface 471854013700 TPR motif; other site 471854013701 TPR repeat; Region: TPR_11; pfam13414 471854013702 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854013703 binding surface 471854013704 TPR motif; other site 471854013705 TPR repeat; Region: TPR_11; pfam13414 471854013706 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854013707 binding surface 471854013708 TPR motif; other site 471854013709 TPR repeat; Region: TPR_11; pfam13414 471854013710 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 471854013711 active site 471854013712 intersubunit interactions; other site 471854013713 catalytic residue [active] 471854013714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854013715 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 471854013716 Walker A/P-loop; other site 471854013717 ATP binding site [chemical binding]; other site 471854013718 Q-loop/lid; other site 471854013719 ABC transporter signature motif; other site 471854013720 Walker B; other site 471854013721 D-loop; other site 471854013722 H-loop/switch region; other site 471854013723 Response regulator receiver domain; Region: Response_reg; pfam00072 471854013724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854013725 active site 471854013726 phosphorylation site [posttranslational modification] 471854013727 intermolecular recognition site; other site 471854013728 dimerization interface [polypeptide binding]; other site 471854013729 PglZ domain; Region: PglZ; pfam08665 471854013730 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 471854013731 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 471854013732 Ligand binding site; other site 471854013733 oligomer interface; other site 471854013734 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471854013735 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 471854013736 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471854013737 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 471854013738 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 471854013739 Trehalose utilisation; Region: ThuA; pfam06283 471854013740 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471854013741 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 471854013742 FOG: PKD repeat [General function prediction only]; Region: COG3291 471854013743 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 471854013744 Cytochrome c; Region: Cytochrom_C; cl11414 471854013745 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 471854013746 metal binding site [ion binding]; metal-binding site 471854013747 ligand binding site [chemical binding]; other site 471854013748 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471854013749 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471854013750 Metal-binding active site; metal-binding site 471854013751 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 471854013752 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 471854013753 four helix bundle protein; Region: TIGR02436 471854013754 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854013755 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854013756 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471854013757 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854013758 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854013759 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471854013760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854013761 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471854013762 putative substrate translocation pore; other site 471854013763 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 471854013764 MutS domain III; Region: MutS_III; pfam05192 471854013765 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 471854013766 Walker A/P-loop; other site 471854013767 ATP binding site [chemical binding]; other site 471854013768 Q-loop/lid; other site 471854013769 ABC transporter signature motif; other site 471854013770 Walker B; other site 471854013771 D-loop; other site 471854013772 H-loop/switch region; other site 471854013773 Smr domain; Region: Smr; pfam01713 471854013774 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 471854013775 NUMOD4 motif; Region: NUMOD4; pfam07463 471854013776 HNH endonuclease; Region: HNH_3; pfam13392 471854013777 CoA binding domain; Region: CoA_binding_2; pfam13380 471854013778 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 471854013779 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 471854013780 dimer interface [polypeptide binding]; other site 471854013781 active site 471854013782 CoA binding pocket [chemical binding]; other site 471854013783 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 471854013784 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 471854013785 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 471854013786 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 471854013787 putative SAM binding site [chemical binding]; other site 471854013788 homodimer interface [polypeptide binding]; other site 471854013789 acyl-CoA esterase; Provisional; Region: PRK10673 471854013790 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471854013791 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854013792 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471854013793 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 471854013794 putative active site [active] 471854013795 catalytic site [active] 471854013796 putative metal binding site [ion binding]; other site 471854013797 oligomer interface [polypeptide binding]; other site 471854013798 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 471854013799 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 471854013800 active site 471854013801 nucleophile elbow; other site 471854013802 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 471854013803 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471854013804 substrate binding pocket [chemical binding]; other site 471854013805 chain length determination region; other site 471854013806 substrate-Mg2+ binding site; other site 471854013807 catalytic residues [active] 471854013808 aspartate-rich region 1; other site 471854013809 active site lid residues [active] 471854013810 aspartate-rich region 2; other site 471854013811 Leucine rich repeat; Region: LRR_8; pfam13855 471854013812 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 471854013813 Leucine-rich repeats; other site 471854013814 Substrate binding site [chemical binding]; other site 471854013815 Leucine rich repeat; Region: LRR_8; pfam13855 471854013816 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 471854013817 Leucine rich repeat; Region: LRR_8; pfam13855 471854013818 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 471854013819 putative ligand binding site [chemical binding]; other site 471854013820 integral membrane protein; Region: integ_memb_HG; TIGR03954 471854013821 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 471854013822 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471854013823 hydroxyglutarate oxidase; Provisional; Region: PRK11728 471854013824 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 471854013825 CcmE; Region: CcmE; cl00994 471854013826 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 471854013827 CcmB protein; Region: CcmB; cl17444 471854013828 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 471854013829 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 471854013830 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 471854013831 G1 box; other site 471854013832 GTP/Mg2+ binding site [chemical binding]; other site 471854013833 Switch I region; other site 471854013834 G2 box; other site 471854013835 G3 box; other site 471854013836 Switch II region; other site 471854013837 G4 box; other site 471854013838 G5 box; other site 471854013839 Nucleoside recognition; Region: Gate; pfam07670 471854013840 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 471854013841 Nucleoside recognition; Region: Gate; pfam07670 471854013842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 471854013843 Protein of unknown function (DUF433); Region: DUF433; pfam04255 471854013844 putative carbohydrate kinase; Provisional; Region: PRK10565 471854013845 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 471854013846 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 471854013847 putative substrate binding site [chemical binding]; other site 471854013848 putative ATP binding site [chemical binding]; other site 471854013849 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 471854013850 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 471854013851 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 471854013852 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 471854013853 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471854013854 active site residue [active] 471854013855 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471854013856 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471854013857 ATP binding site [chemical binding]; other site 471854013858 Mg++ binding site [ion binding]; other site 471854013859 motif III; other site 471854013860 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854013861 nucleotide binding region [chemical binding]; other site 471854013862 ATP-binding site [chemical binding]; other site 471854013863 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 471854013864 putative active site [active] 471854013865 Zn binding site [ion binding]; other site 471854013866 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 471854013867 active site flap/lid [active] 471854013868 nucleophilic elbow; other site 471854013869 catalytic triad [active] 471854013870 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 471854013871 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 471854013872 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 471854013873 Ligand binding site; other site 471854013874 Putative Catalytic site; other site 471854013875 DXD motif; other site 471854013876 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471854013877 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 471854013878 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471854013879 PYR/PP interface [polypeptide binding]; other site 471854013880 dimer interface [polypeptide binding]; other site 471854013881 TPP binding site [chemical binding]; other site 471854013882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854013883 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471854013884 NAD(P) binding site [chemical binding]; other site 471854013885 active site 471854013886 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 471854013887 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 471854013888 Ligand binding site; other site 471854013889 Putative Catalytic site; other site 471854013890 DXD motif; other site 471854013891 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 471854013892 TPP-binding site [chemical binding]; other site 471854013893 dimer interface [polypeptide binding]; other site 471854013894 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 471854013895 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471854013896 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 471854013897 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471854013898 ligand binding site [chemical binding]; other site 471854013899 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 471854013900 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 471854013901 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 471854013902 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 471854013903 substrate binding site [chemical binding]; other site 471854013904 hexamer interface [polypeptide binding]; other site 471854013905 metal binding site [ion binding]; metal-binding site 471854013906 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471854013907 putative active site [active] 471854013908 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 471854013909 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 471854013910 nucleotide binding pocket [chemical binding]; other site 471854013911 K-X-D-G motif; other site 471854013912 catalytic site [active] 471854013913 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 471854013914 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 471854013915 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 471854013916 Dimer interface [polypeptide binding]; other site 471854013917 BRCT sequence motif; other site 471854013918 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 471854013919 dihydrodipicolinate synthase; Region: dapA; TIGR00674 471854013920 dimer interface [polypeptide binding]; other site 471854013921 active site 471854013922 catalytic residue [active] 471854013923 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 471854013924 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471854013925 catalytic residue [active] 471854013926 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 471854013927 nudix motif; other site 471854013928 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 471854013929 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 471854013930 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 471854013931 metal binding site [ion binding]; metal-binding site 471854013932 peptidase T; Region: peptidase-T; TIGR01882 471854013933 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 471854013934 metal binding site [ion binding]; metal-binding site 471854013935 dimer interface [polypeptide binding]; other site 471854013936 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 471854013937 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 471854013938 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 471854013939 active site 471854013940 RNA/DNA hybrid binding site [nucleotide binding]; other site 471854013941 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 471854013942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854013943 S-adenosylmethionine binding site [chemical binding]; other site 471854013944 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 471854013945 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 471854013946 Ligand binding site; other site 471854013947 Putative Catalytic site; other site 471854013948 DXD motif; other site 471854013949 inorganic pyrophosphatase; Provisional; Region: PRK00642 471854013950 dimer interface [polypeptide binding]; other site 471854013951 substrate binding site [chemical binding]; other site 471854013952 metal binding sites [ion binding]; metal-binding site 471854013953 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 471854013954 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 471854013955 G1 box; other site 471854013956 putative GEF interaction site [polypeptide binding]; other site 471854013957 GTP/Mg2+ binding site [chemical binding]; other site 471854013958 Switch I region; other site 471854013959 G2 box; other site 471854013960 G3 box; other site 471854013961 Switch II region; other site 471854013962 G4 box; other site 471854013963 G5 box; other site 471854013964 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 471854013965 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 471854013966 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854013967 active site 471854013968 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 471854013969 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 471854013970 active site 471854013971 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854013972 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854013973 Amidohydrolase; Region: Amidohydro_4; pfam13147 471854013974 active site 471854013975 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 471854013976 S1 domain; Region: S1_2; pfam13509 471854013977 S1 domain; Region: S1_2; pfam13509 471854013978 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854013979 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854013980 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854013981 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 471854013982 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471854013983 active site 471854013984 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 471854013985 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471854013986 inhibitor-cofactor binding pocket; inhibition site 471854013987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854013988 catalytic residue [active] 471854013989 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471854013990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854013991 NAD(P) binding site [chemical binding]; other site 471854013992 active site 471854013993 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854013994 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471854013995 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 471854013996 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 471854013997 Protein export membrane protein; Region: SecD_SecF; cl14618 471854013998 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854013999 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854014000 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854014001 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 471854014002 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471854014003 CoenzymeA binding site [chemical binding]; other site 471854014004 subunit interaction site [polypeptide binding]; other site 471854014005 PHB binding site; other site 471854014006 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471854014007 catalytic core [active] 471854014008 Histidine kinase; Region: His_kinase; pfam06580 471854014009 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 471854014010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014011 active site 471854014012 phosphorylation site [posttranslational modification] 471854014013 intermolecular recognition site; other site 471854014014 dimerization interface [polypeptide binding]; other site 471854014015 LytTr DNA-binding domain; Region: LytTR; smart00850 471854014016 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 471854014017 hypothetical protein; Reviewed; Region: PRK00024 471854014018 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 471854014019 MPN+ (JAMM) motif; other site 471854014020 Zinc-binding site [ion binding]; other site 471854014021 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 471854014022 Putative zinc ribbon domain; Region: DUF164; pfam02591 471854014023 Uncharacterized conserved protein [Function unknown]; Region: COG0327 471854014024 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 471854014025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 471854014026 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 471854014027 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 471854014028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471854014029 putative DNA binding site [nucleotide binding]; other site 471854014030 putative Zn2+ binding site [ion binding]; other site 471854014031 AsnC family; Region: AsnC_trans_reg; pfam01037 471854014032 Predicted transcriptional regulators [Transcription]; Region: COG1695 471854014033 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471854014034 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 471854014035 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 471854014036 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471854014037 active site 471854014038 catalytic site [active] 471854014039 substrate binding site [chemical binding]; other site 471854014040 Fatty-acid desaturase [Lipid metabolism]; Region: OLE1; cl17656 471854014041 Fatty acid desaturase; Region: FA_desaturase; pfam00487 471854014042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014043 active site 471854014044 phosphorylation site [posttranslational modification] 471854014045 intermolecular recognition site; other site 471854014046 dimerization interface [polypeptide binding]; other site 471854014047 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 471854014048 DNA-binding site [nucleotide binding]; DNA binding site 471854014049 RNA-binding motif; other site 471854014050 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 471854014051 putative acyl-acceptor binding pocket; other site 471854014052 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 471854014053 active site 471854014054 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854014055 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 471854014056 putative ADP-binding pocket [chemical binding]; other site 471854014057 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854014058 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 471854014059 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 471854014060 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 471854014061 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 471854014062 Response regulator receiver domain; Region: Response_reg; pfam00072 471854014063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014064 active site 471854014065 phosphorylation site [posttranslational modification] 471854014066 intermolecular recognition site; other site 471854014067 dimerization interface [polypeptide binding]; other site 471854014068 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 471854014069 CHC2 zinc finger; Region: zf-CHC2; cl17510 471854014070 Toprim-like; Region: Toprim_2; pfam13155 471854014071 Phage associated DNA primase [General function prediction only]; Region: COG3378 471854014072 Helix-turn-helix domain; Region: HTH_17; pfam12728 471854014073 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471854014074 active site 471854014075 DNA binding site [nucleotide binding] 471854014076 Int/Topo IB signature motif; other site 471854014077 Response regulator receiver domain; Region: Response_reg; pfam00072 471854014078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014079 active site 471854014080 phosphorylation site [posttranslational modification] 471854014081 intermolecular recognition site; other site 471854014082 dimerization interface [polypeptide binding]; other site 471854014083 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854014084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854014085 dimer interface [polypeptide binding]; other site 471854014086 phosphorylation site [posttranslational modification] 471854014087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854014088 ATP binding site [chemical binding]; other site 471854014089 Mg2+ binding site [ion binding]; other site 471854014090 G-X-G motif; other site 471854014091 CheB methylesterase; Region: CheB_methylest; pfam01339 471854014092 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 471854014093 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 471854014094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854014095 S-adenosylmethionine binding site [chemical binding]; other site 471854014096 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 471854014097 PAS domain; Region: PAS_10; pfam13596 471854014098 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854014099 putative active site [active] 471854014100 heme pocket [chemical binding]; other site 471854014101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854014102 PAS domain; Region: PAS_9; pfam13426 471854014103 putative active site [active] 471854014104 heme pocket [chemical binding]; other site 471854014105 PAS domain S-box; Region: sensory_box; TIGR00229 471854014106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854014107 putative active site [active] 471854014108 heme pocket [chemical binding]; other site 471854014109 PAS fold; Region: PAS_4; pfam08448 471854014110 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854014111 putative active site [active] 471854014112 heme pocket [chemical binding]; other site 471854014113 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 471854014114 CheB methylesterase; Region: CheB_methylest; pfam01339 471854014115 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 471854014116 Response regulator receiver domain; Region: Response_reg; pfam00072 471854014117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014118 active site 471854014119 phosphorylation site [posttranslational modification] 471854014120 intermolecular recognition site; other site 471854014121 dimerization interface [polypeptide binding]; other site 471854014122 Response regulator receiver domain; Region: Response_reg; pfam00072 471854014123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014124 active site 471854014125 phosphorylation site [posttranslational modification] 471854014126 intermolecular recognition site; other site 471854014127 dimerization interface [polypeptide binding]; other site 471854014128 Melibiase; Region: Melibiase; pfam02065 471854014129 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 471854014130 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 471854014131 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 471854014132 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 471854014133 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 471854014134 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 471854014135 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 471854014136 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 471854014137 putative active site [active] 471854014138 SPFH domain / Band 7 family; Region: Band_7; pfam01145 471854014139 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 471854014140 Predicted transcriptional regulators [Transcription]; Region: COG1725 471854014141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471854014142 DNA-binding site [nucleotide binding]; DNA binding site 471854014143 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471854014144 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471854014145 Walker A/P-loop; other site 471854014146 ATP binding site [chemical binding]; other site 471854014147 Q-loop/lid; other site 471854014148 ABC transporter signature motif; other site 471854014149 Walker B; other site 471854014150 D-loop; other site 471854014151 H-loop/switch region; other site 471854014152 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 471854014153 Ligand binding site; other site 471854014154 metal-binding site 471854014155 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 471854014156 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 471854014157 XdhC Rossmann domain; Region: XdhC_C; pfam13478 471854014158 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471854014159 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 471854014160 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471854014161 catalytic residue [active] 471854014162 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 471854014163 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 471854014164 dimer interface [polypeptide binding]; other site 471854014165 decamer (pentamer of dimers) interface [polypeptide binding]; other site 471854014166 catalytic triad [active] 471854014167 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854014168 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854014169 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854014170 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 471854014171 heat shock protein 90; Provisional; Region: PRK05218 471854014172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854014173 ATP binding site [chemical binding]; other site 471854014174 Mg2+ binding site [ion binding]; other site 471854014175 G-X-G motif; other site 471854014176 transcription termination factor Rho; Provisional; Region: PRK12678 471854014177 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 471854014178 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 471854014179 RNA binding site [nucleotide binding]; other site 471854014180 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 471854014181 multimer interface [polypeptide binding]; other site 471854014182 Walker A motif; other site 471854014183 ATP binding site [chemical binding]; other site 471854014184 Walker B motif; other site 471854014185 pantothenate kinase; Reviewed; Region: PRK13320 471854014186 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 471854014187 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471854014188 Cytochrome c; Region: Cytochrom_C; pfam00034 471854014189 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 471854014190 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 471854014191 Cu(I) binding site [ion binding]; other site 471854014192 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 471854014193 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 471854014194 Walker A/P-loop; other site 471854014195 ATP binding site [chemical binding]; other site 471854014196 Q-loop/lid; other site 471854014197 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 471854014198 Q-loop/lid; other site 471854014199 ABC transporter signature motif; other site 471854014200 Walker B; other site 471854014201 D-loop; other site 471854014202 H-loop/switch region; other site 471854014203 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 471854014204 Flavoprotein; Region: Flavoprotein; pfam02441 471854014205 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 471854014206 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 471854014207 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854014208 OstA-like protein; Region: OstA_2; pfam13100 471854014209 OstA-like protein; Region: OstA_2; pfam13100 471854014210 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 471854014211 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 471854014212 Ligand Binding Site [chemical binding]; other site 471854014213 TilS substrate C-terminal domain; Region: TilS_C; smart00977 471854014214 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 471854014215 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 471854014216 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 471854014217 Int/Topo IB signature motif; other site 471854014218 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471854014219 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471854014220 ATP binding site [chemical binding]; other site 471854014221 putative Mg++ binding site [ion binding]; other site 471854014222 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 471854014223 nucleotide binding region [chemical binding]; other site 471854014224 ATP-binding site [chemical binding]; other site 471854014225 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 471854014226 YcaO-like family; Region: YcaO; pfam02624 471854014227 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 471854014228 putative active site [active] 471854014229 catalytic site [active] 471854014230 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 471854014231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471854014232 ATP binding site [chemical binding]; other site 471854014233 putative Mg++ binding site [ion binding]; other site 471854014234 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471854014235 nucleotide binding region [chemical binding]; other site 471854014236 ATP-binding site [chemical binding]; other site 471854014237 Restriction endonuclease [Defense mechanisms]; Region: COG3587 471854014238 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471854014239 ATP binding site [chemical binding]; other site 471854014240 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 471854014241 DNA methylase; Region: N6_N4_Mtase; cl17433 471854014242 DNA methylase; Region: N6_N4_Mtase; pfam01555 471854014243 DNA methylase; Region: N6_N4_Mtase; cl17433 471854014244 conjugal transfer protein TraL; Provisional; Region: PRK13886 471854014245 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 471854014246 Antirestriction protein (ArdA); Region: ArdA; pfam07275 471854014247 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471854014248 active site 471854014249 NTP binding site [chemical binding]; other site 471854014250 metal binding triad [ion binding]; metal-binding site 471854014251 antibiotic binding site [chemical binding]; other site 471854014252 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 471854014253 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 471854014254 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471854014255 ATP binding site [chemical binding]; other site 471854014256 putative Mg++ binding site [ion binding]; other site 471854014257 Abortive infection C-terminus; Region: Abi_C; pfam14355 471854014258 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 471854014259 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471854014260 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471854014261 active site 471854014262 NTP binding site [chemical binding]; other site 471854014263 metal binding triad [ion binding]; metal-binding site 471854014264 Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748 471854014265 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 471854014266 Vitamin K epoxide reductase (VKOR) family in bacteria; Region: VKOR_4; cd12921 471854014267 putative active site [active] 471854014268 redox center [active] 471854014269 Thioredoxin; Region: Thioredoxin_4; cl17273 471854014270 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 471854014271 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471854014272 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471854014273 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471854014274 active site 471854014275 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 471854014276 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 471854014277 putative active site [active] 471854014278 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471854014279 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854014280 Walker A/P-loop; other site 471854014281 ATP binding site [chemical binding]; other site 471854014282 Q-loop/lid; other site 471854014283 ABC transporter signature motif; other site 471854014284 Walker B; other site 471854014285 D-loop; other site 471854014286 H-loop/switch region; other site 471854014287 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 471854014288 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854014289 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 471854014290 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 471854014291 putative transporter; Provisional; Region: PRK10484 471854014292 Na binding site [ion binding]; other site 471854014293 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 471854014294 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 471854014295 classical (c) SDRs; Region: SDR_c; cd05233 471854014296 NAD(P) binding site [chemical binding]; other site 471854014297 active site 471854014298 galactonate dehydratase; Provisional; Region: PRK14017 471854014299 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 471854014300 metal binding site [ion binding]; metal-binding site 471854014301 substrate binding pocket [chemical binding]; other site 471854014302 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 471854014303 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471854014304 inhibitor-cofactor binding pocket; inhibition site 471854014305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854014306 catalytic residue [active] 471854014307 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854014308 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854014309 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854014310 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854014311 SusD family; Region: SusD; pfam07980 471854014312 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854014313 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854014314 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854014315 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471854014316 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471854014317 DNA-binding site [nucleotide binding]; DNA binding site 471854014318 FCD domain; Region: FCD; pfam07729 471854014319 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854014320 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 471854014321 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 471854014322 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 471854014323 PAS fold; Region: PAS_3; pfam08447 471854014324 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854014325 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854014326 DNA binding residues [nucleotide binding] 471854014327 dimerization interface [polypeptide binding]; other site 471854014328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854014329 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 471854014330 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471854014331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854014332 Coenzyme A binding pocket [chemical binding]; other site 471854014333 Cytochrome c; Region: Cytochrom_C; pfam00034 471854014334 Cytochrome c; Region: Cytochrom_C; pfam00034 471854014335 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 471854014336 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854014337 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854014338 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854014339 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 471854014340 dimer interface [polypeptide binding]; other site 471854014341 ligand binding site [chemical binding]; other site 471854014342 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 471854014343 Coenzyme A binding pocket [chemical binding]; other site 471854014344 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 471854014345 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 471854014346 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 471854014347 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 471854014348 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471854014349 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854014350 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 471854014351 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 471854014352 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 471854014353 putative lipid binding site [chemical binding]; other site 471854014354 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 471854014355 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 471854014356 Cl- selectivity filter; other site 471854014357 Cl- binding residues [ion binding]; other site 471854014358 pore gating glutamate residue; other site 471854014359 dimer interface [polypeptide binding]; other site 471854014360 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 471854014361 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 471854014362 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 471854014363 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 471854014364 Cytochrome c; Region: Cytochrom_C; pfam00034 471854014365 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471854014366 dimerization interface [polypeptide binding]; other site 471854014367 putative DNA binding site [nucleotide binding]; other site 471854014368 putative Zn2+ binding site [ion binding]; other site 471854014369 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 471854014370 RNAase interaction site [polypeptide binding]; other site 471854014371 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854014372 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854014373 Uncharacterized conserved protein [Function unknown]; Region: COG2128 471854014374 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 471854014375 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471854014376 DNA-binding site [nucleotide binding]; DNA binding site 471854014377 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471854014378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471854014379 Histidine kinase; Region: His_kinase; pfam06580 471854014380 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471854014381 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854014382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014383 active site 471854014384 phosphorylation site [posttranslational modification] 471854014385 intermolecular recognition site; other site 471854014386 dimerization interface [polypeptide binding]; other site 471854014387 LytTr DNA-binding domain; Region: LytTR; smart00850 471854014388 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854014389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014390 active site 471854014391 phosphorylation site [posttranslational modification] 471854014392 intermolecular recognition site; other site 471854014393 dimerization interface [polypeptide binding]; other site 471854014394 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854014395 DNA binding residues [nucleotide binding] 471854014396 dimerization interface [polypeptide binding]; other site 471854014397 Histidine kinase; Region: His_kinase; pfam06580 471854014398 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 471854014399 ATP binding site [chemical binding]; other site 471854014400 Mg2+ binding site [ion binding]; other site 471854014401 G-X-G motif; other site 471854014402 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 471854014403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014404 active site 471854014405 phosphorylation site [posttranslational modification] 471854014406 intermolecular recognition site; other site 471854014407 dimerization interface [polypeptide binding]; other site 471854014408 LytTr DNA-binding domain; Region: LytTR; smart00850 471854014409 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854014410 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854014411 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854014412 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 471854014413 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 471854014414 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 471854014415 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 471854014416 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 471854014417 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854014418 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471854014419 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854014420 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854014421 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854014422 Histidine kinase; Region: His_kinase; pfam06580 471854014423 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854014424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014425 active site 471854014426 phosphorylation site [posttranslational modification] 471854014427 intermolecular recognition site; other site 471854014428 dimerization interface [polypeptide binding]; other site 471854014429 LytTr DNA-binding domain; Region: LytTR; smart00850 471854014430 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854014431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854014432 dimer interface [polypeptide binding]; other site 471854014433 phosphorylation site [posttranslational modification] 471854014434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854014435 ATP binding site [chemical binding]; other site 471854014436 Mg2+ binding site [ion binding]; other site 471854014437 G-X-G motif; other site 471854014438 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471854014439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014440 active site 471854014441 phosphorylation site [posttranslational modification] 471854014442 intermolecular recognition site; other site 471854014443 dimerization interface [polypeptide binding]; other site 471854014444 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 471854014445 Response regulator receiver domain; Region: Response_reg; pfam00072 471854014446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014447 active site 471854014448 phosphorylation site [posttranslational modification] 471854014449 intermolecular recognition site; other site 471854014450 dimerization interface [polypeptide binding]; other site 471854014451 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471854014452 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 471854014453 ligand binding site [chemical binding]; other site 471854014454 flexible hinge region; other site 471854014455 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 471854014456 putative switch regulator; other site 471854014457 non-specific DNA interactions [nucleotide binding]; other site 471854014458 DNA binding site [nucleotide binding] 471854014459 sequence specific DNA binding site [nucleotide binding]; other site 471854014460 putative cAMP binding site [chemical binding]; other site 471854014461 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471854014462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854014463 putative active site [active] 471854014464 heme pocket [chemical binding]; other site 471854014465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854014466 dimer interface [polypeptide binding]; other site 471854014467 phosphorylation site [posttranslational modification] 471854014468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854014469 ATP binding site [chemical binding]; other site 471854014470 Mg2+ binding site [ion binding]; other site 471854014471 G-X-G motif; other site 471854014472 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 471854014473 HemN C-terminal domain; Region: HemN_C; pfam06969 471854014474 Family description; Region: DsbD_2; pfam13386 471854014475 FixH; Region: FixH; pfam05751 471854014476 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 471854014477 4Fe-4S binding domain; Region: Fer4_5; pfam12801 471854014478 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 471854014479 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 471854014480 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 471854014481 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 471854014482 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 471854014483 Low-spin heme binding site [chemical binding]; other site 471854014484 Putative water exit pathway; other site 471854014485 Binuclear center (active site) [active] 471854014486 Putative proton exit pathway; other site 471854014487 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 471854014488 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 471854014489 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 471854014490 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 471854014491 Heavy-metal-associated domain; Region: HMA; pfam00403 471854014492 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471854014493 Soluble P-type ATPase [General function prediction only]; Region: COG4087 471854014494 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 471854014495 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 471854014496 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 471854014497 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854014498 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854014499 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854014500 DNA binding residues [nucleotide binding] 471854014501 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854014502 FecR protein; Region: FecR; pfam04773 471854014503 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854014504 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854014505 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854014506 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854014507 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854014508 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471854014509 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 471854014510 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 471854014511 Cytochrome c; Region: Cytochrom_C; cl11414 471854014512 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 471854014513 metal binding site [ion binding]; metal-binding site 471854014514 ligand binding site [chemical binding]; other site 471854014515 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 471854014516 dimerization interface [polypeptide binding]; other site 471854014517 putative active cleft [active] 471854014518 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 471854014519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854014520 putative substrate translocation pore; other site 471854014521 MarR family; Region: MarR_2; pfam12802 471854014522 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471854014523 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471854014524 nucleotide binding site [chemical binding]; other site 471854014525 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471854014526 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471854014527 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 471854014528 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 471854014529 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 471854014530 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 471854014531 Moco binding site; other site 471854014532 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 471854014533 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 471854014534 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 471854014535 N-terminal plug; other site 471854014536 ligand-binding site [chemical binding]; other site 471854014537 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 471854014538 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 471854014539 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 471854014540 Reovirus major virion structural protein Mu-1/Mu-1C (M2); Region: Reovirus_M2; pfam05993 471854014541 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854014542 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854014543 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854014544 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854014545 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854014546 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854014547 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854014548 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854014549 Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903 471854014550 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 471854014551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854014552 dimer interface [polypeptide binding]; other site 471854014553 phosphorylation site [posttranslational modification] 471854014554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854014555 ATP binding site [chemical binding]; other site 471854014556 Mg2+ binding site [ion binding]; other site 471854014557 G-X-G motif; other site 471854014558 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471854014559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014560 active site 471854014561 phosphorylation site [posttranslational modification] 471854014562 intermolecular recognition site; other site 471854014563 dimerization interface [polypeptide binding]; other site 471854014564 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471854014565 DNA binding site [nucleotide binding] 471854014566 Domain of unknown function (DU1801); Region: DUF1801; cl17490 471854014567 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 471854014568 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 471854014569 HEAT repeats; Region: HEAT_2; pfam13646 471854014570 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 471854014571 YCII-related domain; Region: YCII; cl00999 471854014572 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471854014573 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854014574 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854014575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014576 active site 471854014577 phosphorylation site [posttranslational modification] 471854014578 intermolecular recognition site; other site 471854014579 dimerization interface [polypeptide binding]; other site 471854014580 LytTr DNA-binding domain; Region: LytTR; smart00850 471854014581 Histidine kinase; Region: His_kinase; pfam06580 471854014582 CHRD domain; Region: CHRD; pfam07452 471854014583 CHRD domain; Region: CHRD; pfam07452 471854014584 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 471854014585 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 471854014586 N-terminal plug; other site 471854014587 ligand-binding site [chemical binding]; other site 471854014588 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 471854014589 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 471854014590 catalytic triad [active] 471854014591 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 471854014592 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 471854014593 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 471854014594 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 471854014595 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 471854014596 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854014597 Walker A motif; other site 471854014598 ATP binding site [chemical binding]; other site 471854014599 Walker B motif; other site 471854014600 arginine finger; other site 471854014601 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 471854014602 metal ion-dependent adhesion site (MIDAS); other site 471854014603 cobyric acid synthase; Provisional; Region: PRK00784 471854014604 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 471854014605 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 471854014606 catalytic triad [active] 471854014607 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 471854014608 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471854014609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471854014610 homodimer interface [polypeptide binding]; other site 471854014611 catalytic residue [active] 471854014612 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 471854014613 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 471854014614 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471854014615 putative ligand binding site [chemical binding]; other site 471854014616 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 471854014617 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 471854014618 homotrimer interface [polypeptide binding]; other site 471854014619 Walker A motif; other site 471854014620 GTP binding site [chemical binding]; other site 471854014621 Walker B motif; other site 471854014622 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 471854014623 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 471854014624 putative dimer interface [polypeptide binding]; other site 471854014625 active site pocket [active] 471854014626 putative cataytic base [active] 471854014627 cobalamin synthase; Reviewed; Region: cobS; PRK00235 471854014628 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471854014629 catalytic core [active] 471854014630 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 471854014631 DinB superfamily; Region: DinB_2; pfam12867 471854014632 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854014633 DoxX-like family; Region: DoxX_2; pfam13564 471854014634 Phosphoesterase family; Region: Phosphoesterase; pfam04185 471854014635 Phosphoesterase family; Region: Phosphoesterase; pfam04185 471854014636 Domain of unknown function (DUF756); Region: DUF756; pfam05506 471854014637 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854014638 Fic family protein [Function unknown]; Region: COG3177 471854014639 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 471854014640 Fic/DOC family; Region: Fic; pfam02661 471854014641 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471854014642 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471854014643 active site 471854014644 metal binding site [ion binding]; metal-binding site 471854014645 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854014646 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 471854014647 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 471854014648 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471854014649 FeS/SAM binding site; other site 471854014650 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 471854014651 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 471854014652 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 471854014653 putative active site [active] 471854014654 putative PHP Thumb interface [polypeptide binding]; other site 471854014655 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 471854014656 generic binding surface II; other site 471854014657 generic binding surface I; other site 471854014658 DNA Polymerase Y-family; Region: PolY_like; cd03468 471854014659 active site 471854014660 DNA binding site [nucleotide binding] 471854014661 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471854014662 dimerization interface [polypeptide binding]; other site 471854014663 putative DNA binding site [nucleotide binding]; other site 471854014664 putative Zn2+ binding site [ion binding]; other site 471854014665 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 471854014666 putative hydrophobic ligand binding site [chemical binding]; other site 471854014667 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 471854014668 Uncharacterized conserved protein [Function unknown]; Region: COG4544 471854014669 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 471854014670 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854014671 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 471854014672 dimer interface [polypeptide binding]; other site 471854014673 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854014674 Histidine kinase; Region: His_kinase; pfam06580 471854014675 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854014676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014677 active site 471854014678 phosphorylation site [posttranslational modification] 471854014679 intermolecular recognition site; other site 471854014680 dimerization interface [polypeptide binding]; other site 471854014681 LytTr DNA-binding domain; Region: LytTR; smart00850 471854014682 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 471854014683 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471854014684 metal ion-dependent adhesion site (MIDAS); other site 471854014685 Tenuivirus/Phlebovirus nucleocapsid protein; Region: Tenui_N; pfam05733 471854014686 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471854014687 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471854014688 catalytic residues [active] 471854014689 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471854014690 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854014691 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471854014692 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471854014693 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471854014694 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854014695 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 471854014696 dimer interface [polypeptide binding]; other site 471854014697 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471854014698 putative DNA binding site [nucleotide binding]; other site 471854014699 dimerization interface [polypeptide binding]; other site 471854014700 putative Zn2+ binding site [ion binding]; other site 471854014701 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 471854014702 putative hydrophobic ligand binding site [chemical binding]; other site 471854014703 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471854014704 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 471854014705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854014706 NAD(P) binding site [chemical binding]; other site 471854014707 active site 471854014708 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 471854014709 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471854014710 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 471854014711 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471854014712 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471854014713 Pirin-related protein [General function prediction only]; Region: COG1741 471854014714 Pirin; Region: Pirin; pfam02678 471854014715 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 471854014716 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 471854014717 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854014718 FtsX-like permease family; Region: FtsX; pfam02687 471854014719 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854014720 FtsX-like permease family; Region: FtsX; pfam02687 471854014721 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 471854014722 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 471854014723 putative active site pocket [active] 471854014724 dimerization interface [polypeptide binding]; other site 471854014725 putative catalytic residue [active] 471854014726 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854014727 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471854014728 FtsX-like permease family; Region: FtsX; pfam02687 471854014729 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471854014730 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854014731 FtsX-like permease family; Region: FtsX; pfam02687 471854014732 RibD C-terminal domain; Region: RibD_C; cl17279 471854014733 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471854014734 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854014735 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 471854014736 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 471854014737 active site 471854014738 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 471854014739 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 471854014740 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 471854014741 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854014742 FtsX-like permease family; Region: FtsX; pfam02687 471854014743 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854014744 FtsX-like permease family; Region: FtsX; pfam02687 471854014745 Ferritin-like domain; Region: Ferritin_2; pfam13668 471854014746 Ferritin-like domain; Region: Ferritin_2; pfam13668 471854014747 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 471854014748 Fasciclin domain; Region: Fasciclin; pfam02469 471854014749 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854014750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854014751 dimer interface [polypeptide binding]; other site 471854014752 phosphorylation site [posttranslational modification] 471854014753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854014754 ATP binding site [chemical binding]; other site 471854014755 Mg2+ binding site [ion binding]; other site 471854014756 G-X-G motif; other site 471854014757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854014758 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471854014759 NAD(P) binding site [chemical binding]; other site 471854014760 active site 471854014761 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 471854014762 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 471854014763 substrate binding pocket [chemical binding]; other site 471854014764 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471854014765 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471854014766 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 471854014767 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 471854014768 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 471854014769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854014770 ATP binding site [chemical binding]; other site 471854014771 Walker B motif; other site 471854014772 arginine finger; other site 471854014773 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471854014774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854014775 active site 471854014776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854014777 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471854014778 NAD(P) binding site [chemical binding]; other site 471854014779 active site 471854014780 Cupin domain; Region: Cupin_2; pfam07883 471854014781 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854014782 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854014783 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854014784 Predicted membrane protein [Function unknown]; Region: COG2259 471854014785 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 471854014786 Isochorismatase family; Region: Isochorismatase; pfam00857 471854014787 catalytic triad [active] 471854014788 dimer interface [polypeptide binding]; other site 471854014789 conserved cis-peptide bond; other site 471854014790 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 471854014791 NADP binding site [chemical binding]; other site 471854014792 active site 471854014793 steroid binding site; other site 471854014794 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 471854014795 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 471854014796 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 471854014797 active site 471854014798 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471854014799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014800 active site 471854014801 phosphorylation site [posttranslational modification] 471854014802 intermolecular recognition site; other site 471854014803 dimerization interface [polypeptide binding]; other site 471854014804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854014805 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471854014806 Walker A motif; other site 471854014807 ATP binding site [chemical binding]; other site 471854014808 Walker B motif; other site 471854014809 arginine finger; other site 471854014810 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854014811 binding surface 471854014812 TPR motif; other site 471854014813 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854014814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 471854014815 Histidine kinase; Region: HisKA_2; pfam07568 471854014816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854014817 ATP binding site [chemical binding]; other site 471854014818 Mg2+ binding site [ion binding]; other site 471854014819 G-X-G motif; other site 471854014820 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471854014821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014822 active site 471854014823 phosphorylation site [posttranslational modification] 471854014824 intermolecular recognition site; other site 471854014825 dimerization interface [polypeptide binding]; other site 471854014826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854014827 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471854014828 Walker A motif; other site 471854014829 ATP binding site [chemical binding]; other site 471854014830 Walker B motif; other site 471854014831 arginine finger; other site 471854014832 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 471854014833 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854014834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854014835 binding surface 471854014836 TPR motif; other site 471854014837 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471854014838 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 471854014839 Histidine kinase; Region: HisKA_2; pfam07568 471854014840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854014841 ATP binding site [chemical binding]; other site 471854014842 Mg2+ binding site [ion binding]; other site 471854014843 G-X-G motif; other site 471854014844 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854014845 short chain dehydrogenase; Provisional; Region: PRK06197 471854014846 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 471854014847 putative NAD(P) binding site [chemical binding]; other site 471854014848 active site 471854014849 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854014850 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854014851 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854014852 DNA binding residues [nucleotide binding] 471854014853 Predicted membrane protein [Function unknown]; Region: COG2323 471854014854 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 471854014855 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 471854014856 DNA binding site [nucleotide binding] 471854014857 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 471854014858 active site 471854014859 homodimer interface [polypeptide binding]; other site 471854014860 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 471854014861 active site 471854014862 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 471854014863 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 471854014864 NodB motif; other site 471854014865 putative active site [active] 471854014866 putative catalytic site [active] 471854014867 putative Zn binding site [ion binding]; other site 471854014868 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 471854014869 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471854014870 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 471854014871 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 471854014872 active site 471854014873 dimer interface [polypeptide binding]; other site 471854014874 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 471854014875 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 471854014876 active site 471854014877 FMN binding site [chemical binding]; other site 471854014878 substrate binding site [chemical binding]; other site 471854014879 3Fe-4S cluster binding site [ion binding]; other site 471854014880 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 471854014881 domain interface; other site 471854014882 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 471854014883 ATP binding site [chemical binding]; other site 471854014884 active site 471854014885 substrate binding site [chemical binding]; other site 471854014886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471854014887 TPR motif; other site 471854014888 binding surface 471854014889 von Willebrand factor type A domain; Region: VWA_2; pfam13519 471854014890 metal ion-dependent adhesion site (MIDAS); other site 471854014891 Uncharacterized conserved protein [Function unknown]; Region: COG4127 471854014892 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 471854014893 Catalytic site [active] 471854014894 Helix-turn-helix domain; Region: HTH_17; pfam12728 471854014895 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471854014896 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471854014897 dimer interface [polypeptide binding]; other site 471854014898 ssDNA binding site [nucleotide binding]; other site 471854014899 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471854014900 DNA polymerase III subunit beta; Validated; Region: PRK05643 471854014901 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 471854014902 putative DNA binding surface [nucleotide binding]; other site 471854014903 dimer interface [polypeptide binding]; other site 471854014904 beta-clamp/clamp loader binding surface; other site 471854014905 beta-clamp/translesion DNA polymerase binding surface; other site 471854014906 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 471854014907 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 471854014908 DNA-binding interface [nucleotide binding]; DNA binding site 471854014909 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 471854014910 Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749 471854014911 Phage terminase, small subunit; Region: Terminase_4; pfam05119 471854014912 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 471854014913 Phage portal protein; Region: Phage_portal; pfam04860 471854014914 Phage-related protein [Function unknown]; Region: COG4695; cl01923 471854014915 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 471854014916 Phage capsid family; Region: Phage_capsid; pfam05065 471854014917 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 471854014918 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 471854014919 long tail fiber, proximal subunit; Provisional; Region: 34; PHA02584 471854014920 Beta-lactamase; Region: Beta-lactamase; pfam00144 471854014921 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471854014922 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 471854014923 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 471854014924 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471854014925 non-specific DNA binding site [nucleotide binding]; other site 471854014926 salt bridge; other site 471854014927 sequence-specific DNA binding site [nucleotide binding]; other site 471854014928 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471854014929 active site 471854014930 DNA binding site [nucleotide binding] 471854014931 Int/Topo IB signature motif; other site 471854014932 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 471854014933 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 471854014934 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854014935 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854014936 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854014937 Predicted transcriptional regulator [Transcription]; Region: COG2345 471854014938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 471854014939 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 471854014940 Membrane transport protein; Region: Mem_trans; cl09117 471854014941 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854014942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854014943 active site 471854014944 phosphorylation site [posttranslational modification] 471854014945 intermolecular recognition site; other site 471854014946 dimerization interface [polypeptide binding]; other site 471854014947 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854014948 DNA binding residues [nucleotide binding] 471854014949 dimerization interface [polypeptide binding]; other site 471854014950 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 471854014951 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 471854014952 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471854014953 Histidine kinase; Region: HisKA_3; pfam07730 471854014954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854014955 ATP binding site [chemical binding]; other site 471854014956 Mg2+ binding site [ion binding]; other site 471854014957 G-X-G motif; other site 471854014958 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854014959 FtsX-like permease family; Region: FtsX; pfam02687 471854014960 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471854014961 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471854014962 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854014963 FtsX-like permease family; Region: FtsX; pfam02687 471854014964 Verru_Chthon cassette protein D; Region: TIGR02596 471854014965 Predicted transcriptional regulators [Transcription]; Region: COG1733 471854014966 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471854014967 putative DNA binding site [nucleotide binding]; other site 471854014968 putative Zn2+ binding site [ion binding]; other site 471854014969 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 471854014970 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471854014971 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854014972 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471854014973 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471854014974 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 471854014975 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854014976 Coenzyme A binding pocket [chemical binding]; other site 471854014977 short chain dehydrogenase; Provisional; Region: PRK08263 471854014978 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 471854014979 NADP binding site [chemical binding]; other site 471854014980 active site 471854014981 steroid binding site; other site 471854014982 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471854014983 Pirin-related protein [General function prediction only]; Region: COG1741 471854014984 Pirin; Region: Pirin; pfam02678 471854014985 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 471854014986 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471854014987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471854014988 Walker A/P-loop; other site 471854014989 ATP binding site [chemical binding]; other site 471854014990 ABC transporter signature motif; other site 471854014991 Walker B; other site 471854014992 D-loop; other site 471854014993 H-loop/switch region; other site 471854014994 ABC transporter; Region: ABC_tran_2; pfam12848 471854014995 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471854014996 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 471854014997 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471854014998 DNA binding site [nucleotide binding] 471854014999 active site 471854015000 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 471854015001 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 471854015002 Cu(I) binding site [ion binding]; other site 471854015003 EamA-like transporter family; Region: EamA; pfam00892 471854015004 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471854015005 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471854015006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854015007 active site 471854015008 phosphorylation site [posttranslational modification] 471854015009 intermolecular recognition site; other site 471854015010 dimerization interface [polypeptide binding]; other site 471854015011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854015012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854015013 ATP binding site [chemical binding]; other site 471854015014 Mg2+ binding site [ion binding]; other site 471854015015 G-X-G motif; other site 471854015016 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 471854015017 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471854015018 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471854015019 ligand binding site [chemical binding]; other site 471854015020 flexible hinge region; other site 471854015021 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 471854015022 CheB methylesterase; Region: CheB_methylest; pfam01339 471854015023 CheB methylesterase; Region: CheB_methylest; pfam01339 471854015024 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 471854015025 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 471854015026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854015027 S-adenosylmethionine binding site [chemical binding]; other site 471854015028 PAS fold; Region: PAS; pfam00989 471854015029 Protein of unknown function (DUF1633); Region: DUF1633; pfam07794 471854015030 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854015031 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471854015032 putative active site [active] 471854015033 heme pocket [chemical binding]; other site 471854015034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854015035 dimer interface [polypeptide binding]; other site 471854015036 phosphorylation site [posttranslational modification] 471854015037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854015038 ATP binding site [chemical binding]; other site 471854015039 Mg2+ binding site [ion binding]; other site 471854015040 G-X-G motif; other site 471854015041 Response regulator receiver domain; Region: Response_reg; pfam00072 471854015042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854015043 active site 471854015044 phosphorylation site [posttranslational modification] 471854015045 intermolecular recognition site; other site 471854015046 dimerization interface [polypeptide binding]; other site 471854015047 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 471854015048 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 471854015049 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471854015050 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471854015051 hydroperoxidase II; Provisional; Region: katE; PRK11249 471854015052 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 471854015053 tetramer interface [polypeptide binding]; other site 471854015054 heme binding pocket [chemical binding]; other site 471854015055 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 471854015056 domain interactions; other site 471854015057 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 471854015058 dimerization interface [polypeptide binding]; other site 471854015059 metal binding site [ion binding]; metal-binding site 471854015060 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 471854015061 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471854015062 active site 471854015063 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471854015064 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 471854015065 Response regulator receiver domain; Region: Response_reg; pfam00072 471854015066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854015067 active site 471854015068 phosphorylation site [posttranslational modification] 471854015069 intermolecular recognition site; other site 471854015070 dimerization interface [polypeptide binding]; other site 471854015071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854015072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 471854015073 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 471854015074 Response regulator receiver domain; Region: Response_reg; pfam00072 471854015075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854015076 active site 471854015077 phosphorylation site [posttranslational modification] 471854015078 intermolecular recognition site; other site 471854015079 dimerization interface [polypeptide binding]; other site 471854015080 Response regulator receiver domain; Region: Response_reg; pfam00072 471854015081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854015082 active site 471854015083 phosphorylation site [posttranslational modification] 471854015084 intermolecular recognition site; other site 471854015085 dimerization interface [polypeptide binding]; other site 471854015086 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471854015087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471854015088 NAD(P) binding site [chemical binding]; other site 471854015089 active site 471854015090 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 471854015091 classical (c) SDRs; Region: SDR_c; cd05233 471854015092 NAD(P) binding site [chemical binding]; other site 471854015093 active site 471854015094 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854015095 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854015096 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471854015097 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 471854015098 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 471854015099 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 471854015100 putative active site [active] 471854015101 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471854015102 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471854015103 active site 471854015104 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 471854015105 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 471854015106 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 471854015107 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471854015108 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471854015109 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 471854015110 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 471854015111 putative ADP-binding pocket [chemical binding]; other site 471854015112 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 471854015113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471854015114 active site 471854015115 motif I; other site 471854015116 motif II; other site 471854015117 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 471854015118 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 471854015119 putative active site [active] 471854015120 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471854015121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854015122 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 471854015123 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 471854015124 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 471854015125 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854015126 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854015127 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854015128 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854015129 starch binding outer membrane protein SusD; Region: SusD; cd08977 471854015130 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854015131 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 471854015132 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 471854015133 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471854015134 Beta-lactamase; Region: Beta-lactamase; pfam00144 471854015135 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854015136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854015137 dimer interface [polypeptide binding]; other site 471854015138 phosphorylation site [posttranslational modification] 471854015139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854015140 ATP binding site [chemical binding]; other site 471854015141 Mg2+ binding site [ion binding]; other site 471854015142 G-X-G motif; other site 471854015143 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854015144 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854015145 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854015146 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471854015147 FtsX-like permease family; Region: FtsX; pfam02687 471854015148 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854015149 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854015150 Outer membrane efflux protein; Region: OEP; pfam02321 471854015151 Outer membrane efflux protein; Region: OEP; pfam02321 471854015152 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471854015153 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471854015154 Walker A/P-loop; other site 471854015155 ATP binding site [chemical binding]; other site 471854015156 Q-loop/lid; other site 471854015157 ABC transporter signature motif; other site 471854015158 Walker B; other site 471854015159 D-loop; other site 471854015160 H-loop/switch region; other site 471854015161 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854015162 FtsX-like permease family; Region: FtsX; pfam02687 471854015163 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471854015164 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471854015165 FtsX-like permease family; Region: FtsX; pfam02687 471854015166 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 471854015167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854015168 active site 471854015169 phosphorylation site [posttranslational modification] 471854015170 intermolecular recognition site; other site 471854015171 dimerization interface [polypeptide binding]; other site 471854015172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854015173 Walker A motif; other site 471854015174 ATP binding site [chemical binding]; other site 471854015175 Walker B motif; other site 471854015176 arginine finger; other site 471854015177 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 471854015178 HAMP domain; Region: HAMP; pfam00672 471854015179 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 471854015180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854015181 ATP binding site [chemical binding]; other site 471854015182 Mg2+ binding site [ion binding]; other site 471854015183 G-X-G motif; other site 471854015184 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471854015185 active site 471854015186 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 471854015187 Peptidase family M50; Region: Peptidase_M50; pfam02163 471854015188 active site 471854015189 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 471854015190 putative substrate binding region [chemical binding]; other site 471854015191 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 471854015192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471854015193 motif II; other site 471854015194 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 471854015195 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 471854015196 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 471854015197 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471854015198 Beta-Casp domain; Region: Beta-Casp; smart01027 471854015199 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 471854015200 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 471854015201 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 471854015202 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 471854015203 active site 471854015204 HslU subunit interaction site [polypeptide binding]; other site 471854015205 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471854015206 E3 interaction surface; other site 471854015207 lipoyl attachment site [posttranslational modification]; other site 471854015208 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 471854015209 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471854015210 E3 interaction surface; other site 471854015211 lipoyl attachment site [posttranslational modification]; other site 471854015212 e3 binding domain; Region: E3_binding; pfam02817 471854015213 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471854015214 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471854015215 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 471854015216 Ligand binding site; other site 471854015217 Putative Catalytic site; other site 471854015218 DXD motif; other site 471854015219 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 471854015220 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 471854015221 NAD binding site [chemical binding]; other site 471854015222 ligand binding site [chemical binding]; other site 471854015223 catalytic site [active] 471854015224 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 471854015225 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471854015226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854015227 S-adenosylmethionine binding site [chemical binding]; other site 471854015228 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471854015229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854015230 S-adenosylmethionine binding site [chemical binding]; other site 471854015231 GTP-binding protein LepA; Provisional; Region: PRK05433 471854015232 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 471854015233 G1 box; other site 471854015234 putative GEF interaction site [polypeptide binding]; other site 471854015235 GTP/Mg2+ binding site [chemical binding]; other site 471854015236 Switch I region; other site 471854015237 G2 box; other site 471854015238 G3 box; other site 471854015239 Switch II region; other site 471854015240 G4 box; other site 471854015241 G5 box; other site 471854015242 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 471854015243 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 471854015244 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 471854015245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471854015246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471854015247 Outer membrane efflux protein; Region: OEP; pfam02321 471854015248 Outer membrane efflux protein; Region: OEP; pfam02321 471854015249 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471854015250 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471854015251 HlyD family secretion protein; Region: HlyD_3; pfam13437 471854015252 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471854015253 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471854015254 Walker A/P-loop; other site 471854015255 ATP binding site [chemical binding]; other site 471854015256 Q-loop/lid; other site 471854015257 ABC transporter signature motif; other site 471854015258 Walker B; other site 471854015259 D-loop; other site 471854015260 H-loop/switch region; other site 471854015261 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 471854015262 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 471854015263 Walker A/P-loop; other site 471854015264 ATP binding site [chemical binding]; other site 471854015265 Q-loop/lid; other site 471854015266 ABC transporter signature motif; other site 471854015267 Walker B; other site 471854015268 D-loop; other site 471854015269 H-loop/switch region; other site 471854015270 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 471854015271 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 471854015272 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471854015273 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 471854015274 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 471854015275 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471854015276 putative NAD(P) binding site [chemical binding]; other site 471854015277 catalytic Zn binding site [ion binding]; other site 471854015278 structural Zn binding site [ion binding]; other site 471854015279 short chain dehydrogenase; Provisional; Region: PRK08628 471854015280 classical (c) SDRs; Region: SDR_c; cd05233 471854015281 NAD(P) binding site [chemical binding]; other site 471854015282 active site 471854015283 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 471854015284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854015285 putative substrate translocation pore; other site 471854015286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854015287 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471854015288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854015289 active site 471854015290 phosphorylation site [posttranslational modification] 471854015291 intermolecular recognition site; other site 471854015292 dimerization interface [polypeptide binding]; other site 471854015293 LytTr DNA-binding domain; Region: LytTR; smart00850 471854015294 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 471854015295 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 471854015296 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 471854015297 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 471854015298 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 471854015299 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 471854015300 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471854015301 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471854015302 CsbD-like; Region: CsbD; cl17424 471854015303 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 471854015304 dimerization interface [polypeptide binding]; other site 471854015305 putative active cleft [active] 471854015306 hypothetical protein; Provisional; Region: PRK08609 471854015307 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 471854015308 metal binding triad [ion binding]; metal-binding site 471854015309 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 471854015310 active site 471854015311 AAA domain; Region: AAA_14; pfam13173 471854015312 AAA domain; Region: AAA_22; pfam13401 471854015313 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 471854015314 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471854015315 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471854015316 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 471854015317 dimerization interface [polypeptide binding]; other site 471854015318 KilA-N domain; Region: KilA-N; pfam04383 471854015319 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 471854015320 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854015321 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854015322 DNA binding residues [nucleotide binding] 471854015323 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 471854015324 FecR protein; Region: FecR; pfam04773 471854015325 Secretin and TonB N terminus short domain; Region: STN; pfam07660 471854015326 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854015327 BclB C-terminal domain; Region: exospore_TM; TIGR03721 471854015328 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854015329 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471854015330 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 471854015331 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 471854015332 putative acyl-acceptor binding pocket; other site 471854015333 CHRD domain; Region: CHRD; pfam07452 471854015334 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 471854015335 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 471854015336 motif 1; other site 471854015337 active site 471854015338 motif 2; other site 471854015339 motif 3; other site 471854015340 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 471854015341 DHHA1 domain; Region: DHHA1; pfam02272 471854015342 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 471854015343 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854015344 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854015345 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854015346 wyosine biosynthesis protein TYW1; Region: rSAM_TYW1; TIGR03972 471854015347 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854015348 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854015349 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854015350 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854015351 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854015352 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854015353 SusD family; Region: SusD; pfam07980 471854015354 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854015355 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854015356 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 471854015357 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 471854015358 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854015359 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854015360 SusD family; Region: SusD; pfam07980 471854015361 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854015362 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471854015363 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854015364 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854015365 Methane oxygenase PmoA; Region: PmoA; pfam14100 471854015366 Stress responsive A/B Barrel Domain; Region: Dabb; cl17744 471854015367 Predicted dehydrogenase [General function prediction only]; Region: COG5322 471854015368 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 471854015369 NAD(P) binding pocket [chemical binding]; other site 471854015370 Predicted transcriptional regulators [Transcription]; Region: COG1733 471854015371 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471854015372 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 471854015373 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 471854015374 acyl-coenzyme A oxidase; Region: PLN02526 471854015375 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471854015376 active site 471854015377 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471854015378 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471854015379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471854015380 Coenzyme A binding pocket [chemical binding]; other site 471854015381 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471854015382 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471854015383 putative acyl-acceptor binding pocket; other site 471854015384 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 471854015385 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 471854015386 homodimer interface [polypeptide binding]; other site 471854015387 putative substrate binding pocket [chemical binding]; other site 471854015388 diiron center [ion binding]; other site 471854015389 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 471854015390 Protein of unknown function (DUF433); Region: DUF433; pfam04255 471854015391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 471854015392 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471854015393 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471854015394 Metal-binding active site; metal-binding site 471854015395 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 471854015396 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471854015397 PYR/PP interface [polypeptide binding]; other site 471854015398 dimer interface [polypeptide binding]; other site 471854015399 TPP binding site [chemical binding]; other site 471854015400 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471854015401 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 471854015402 TPP-binding site [chemical binding]; other site 471854015403 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 471854015404 intersubunit interface [polypeptide binding]; other site 471854015405 active site 471854015406 zinc binding site [ion binding]; other site 471854015407 Na+ binding site [ion binding]; other site 471854015408 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 471854015409 putative transporter; Provisional; Region: PRK10484 471854015410 Na binding site [ion binding]; other site 471854015411 substrate binding site [chemical binding]; other site 471854015412 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471854015413 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471854015414 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471854015415 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 471854015416 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 471854015417 tetrameric interface [polypeptide binding]; other site 471854015418 NAD binding site [chemical binding]; other site 471854015419 catalytic residues [active] 471854015420 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471854015421 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 471854015422 substrate binding site [chemical binding]; other site 471854015423 ATP binding site [chemical binding]; other site 471854015424 KduI/IolB family; Region: KduI; pfam04962 471854015425 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471854015426 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471854015427 DNA binding site [nucleotide binding] 471854015428 domain linker motif; other site 471854015429 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471854015430 ligand binding site [chemical binding]; other site 471854015431 dimerization interface [polypeptide binding]; other site 471854015432 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 471854015433 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 471854015434 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 471854015435 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 471854015436 UbiA prenyltransferase family; Region: UbiA; pfam01040 471854015437 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 471854015438 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 471854015439 starch binding outer membrane protein SusD; Region: SusD; cl17845 471854015440 SusD family; Region: SusD; pfam07980 471854015441 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 471854015442 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471854015443 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 471854015444 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471854015445 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471854015446 Walker A/P-loop; other site 471854015447 ATP binding site [chemical binding]; other site 471854015448 Q-loop/lid; other site 471854015449 ABC transporter signature motif; other site 471854015450 Walker B; other site 471854015451 D-loop; other site 471854015452 H-loop/switch region; other site 471854015453 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 471854015454 active site 471854015455 catalytic triad [active] 471854015456 oxyanion hole [active] 471854015457 switch loop; other site 471854015458 Putative esterase; Region: Esterase; pfam00756 471854015459 S-formylglutathione hydrolase; Region: PLN02442 471854015460 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 471854015461 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 471854015462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854015463 putative substrate translocation pore; other site 471854015464 fructokinase; Reviewed; Region: PRK09557 471854015465 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471854015466 nucleotide binding site [chemical binding]; other site 471854015467 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 471854015468 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 471854015469 Putative esterase; Region: Esterase; pfam00756 471854015470 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 471854015471 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 471854015472 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 471854015473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471854015474 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471854015475 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 471854015476 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471854015477 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471854015478 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 471854015479 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471854015480 active site 471854015481 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471854015482 catalytic tetrad [active] 471854015483 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471854015484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854015485 active site 471854015486 phosphorylation site [posttranslational modification] 471854015487 intermolecular recognition site; other site 471854015488 dimerization interface [polypeptide binding]; other site 471854015489 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471854015490 DNA binding residues [nucleotide binding] 471854015491 dimerization interface [polypeptide binding]; other site 471854015492 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 471854015493 Putative Ig domain; Region: He_PIG; pfam05345 471854015494 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 471854015495 YfbU domain; Region: YfbU; cl01137 471854015496 recombination factor protein RarA; Reviewed; Region: PRK13342 471854015497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471854015498 Walker A motif; other site 471854015499 ATP binding site [chemical binding]; other site 471854015500 Walker B motif; other site 471854015501 arginine finger; other site 471854015502 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 471854015503 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471854015504 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471854015505 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471854015506 DNA binding residues [nucleotide binding] 471854015507 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 471854015508 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 471854015509 active site 471854015510 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 471854015511 Cupin domain; Region: Cupin_2; pfam07883 471854015512 Helix-turn-helix domain; Region: HTH_18; pfam12833 471854015513 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 471854015514 galactarate dehydratase; Region: galactar-dH20; TIGR03248 471854015515 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 471854015516 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 471854015517 classical (c) SDRs; Region: SDR_c; cd05233 471854015518 NAD(P) binding site [chemical binding]; other site 471854015519 active site 471854015520 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 471854015521 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 471854015522 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 471854015523 Amidohydrolase; Region: Amidohydro_2; pfam04909 471854015524 active site 471854015525 Domain of unknown function (DUF718); Region: DUF718; pfam05336 471854015526 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471854015527 putative catalytic site [active] 471854015528 putative phosphate binding site [ion binding]; other site 471854015529 putative metal binding site [ion binding]; other site 471854015530 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471854015531 Cysteine-rich domain; Region: CCG; pfam02754 471854015532 Cysteine-rich domain; Region: CCG; pfam02754 471854015533 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 471854015534 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 471854015535 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471854015536 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 471854015537 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471854015538 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471854015539 cytidylate kinase; Provisional; Region: cmk; PRK00023 471854015540 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 471854015541 CMP-binding site; other site 471854015542 The sites determining sugar specificity; other site 471854015543 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 471854015544 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 471854015545 Surface antigen; Region: Bac_surface_Ag; pfam01103 471854015546 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 471854015547 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 471854015548 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 471854015549 TPP-binding site [chemical binding]; other site 471854015550 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 471854015551 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471854015552 E3 interaction surface; other site 471854015553 lipoyl attachment site [posttranslational modification]; other site 471854015554 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471854015555 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 471854015556 E3 interaction surface; other site 471854015557 lipoyl attachment site [posttranslational modification]; other site 471854015558 e3 binding domain; Region: E3_binding; pfam02817 471854015559 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471854015560 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 471854015561 homodimer interface [polypeptide binding]; other site 471854015562 metal binding site [ion binding]; metal-binding site 471854015563 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 471854015564 putative active site [active] 471854015565 dimerization interface [polypeptide binding]; other site 471854015566 putative tRNAtyr binding site [nucleotide binding]; other site 471854015567 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 471854015568 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 471854015569 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 471854015570 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 471854015571 MgtE intracellular N domain; Region: MgtE_N; pfam03448 471854015572 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 471854015573 Divalent cation transporter; Region: MgtE; pfam01769 471854015574 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 471854015575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471854015576 S-adenosylmethionine binding site [chemical binding]; other site 471854015577 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 471854015578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854015579 putative active site [active] 471854015580 heme pocket [chemical binding]; other site 471854015581 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854015582 putative active site [active] 471854015583 heme pocket [chemical binding]; other site 471854015584 GAF domain; Region: GAF_2; pfam13185 471854015585 GAF domain; Region: GAF; pfam01590 471854015586 PAS domain S-box; Region: sensory_box; TIGR00229 471854015587 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 471854015588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471854015589 PAS domain; Region: PAS_9; pfam13426 471854015590 putative active site [active] 471854015591 heme pocket [chemical binding]; other site 471854015592 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471854015593 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471854015594 dimer interface [polypeptide binding]; other site 471854015595 phosphorylation site [posttranslational modification] 471854015596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471854015597 ATP binding site [chemical binding]; other site 471854015598 Mg2+ binding site [ion binding]; other site 471854015599 G-X-G motif; other site 471854015600 Response regulator receiver domain; Region: Response_reg; pfam00072 471854015601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471854015602 active site 471854015603 phosphorylation site [posttranslational modification] 471854015604 intermolecular recognition site; other site 471854015605 dimerization interface [polypeptide binding]; other site 471854015606 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 471854015607 putative binding surface; other site 471854015608 active site 471854015609 Cna protein B-type domain; Region: Cna_B_2; pfam13715 471854015610 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 471854015611 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471854015612 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471854015613 AIR carboxylase; Region: AIRC; pfam00731 471854015614 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 471854015615 ATP-grasp domain; Region: ATP-grasp; pfam02222 471854015616 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 471854015617 oligomeric interface; other site 471854015618 putative active site [active] 471854015619 homodimer interface [polypeptide binding]; other site 471854015620 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 471854015621 YcxB-like protein; Region: YcxB; pfam14317 471854015622 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 471854015623 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 471854015624 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 471854015625 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471854015626 FeS/SAM binding site; other site 471854015627 HemN C-terminal domain; Region: HemN_C; pfam06969 471854015628 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 471854015629 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 471854015630 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 471854015631 Amidinotransferase; Region: Amidinotransf; pfam02274 471854015632 Amidinotransferase; Region: Amidinotransf; cl12043 471854015633 FeS assembly ATPase SufC; Region: sufC; TIGR01978 471854015634 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 471854015635 Walker A/P-loop; other site 471854015636 ATP binding site [chemical binding]; other site 471854015637 Q-loop/lid; other site 471854015638 ABC transporter signature motif; other site 471854015639 Walker B; other site 471854015640 D-loop; other site 471854015641 H-loop/switch region; other site 471854015642 FeS assembly protein SufD; Region: sufD; TIGR01981 471854015643 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 471854015644 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471854015645 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 471854015646 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471854015647 catalytic residue [active] 471854015648 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 471854015649 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 471854015650 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 471854015651 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 471854015652 metal ion-dependent adhesion site (MIDAS); other site 471854015653 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 471854015654 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 471854015655 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 471854015656 active site 471854015657 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471854015658 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 471854015659 acyl-activating enzyme (AAE) consensus motif; other site 471854015660 active site 471854015661 AMP binding site [chemical binding]; other site 471854015662 CoA binding site [chemical binding]; other site 471854015663 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 471854015664 putative active site [active] 471854015665 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 471854015666 O-methyltransferase; Region: Methyltransf_2; pfam00891 471854015667 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 471854015668 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 471854015669 dimer interface [polypeptide binding]; other site 471854015670 active site 471854015671 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 471854015672 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 471854015673 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 471854015674 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471854015675 Walker A/P-loop; other site 471854015676 ATP binding site [chemical binding]; other site 471854015677 Q-loop/lid; other site 471854015678 ABC transporter signature motif; other site 471854015679 Walker B; other site 471854015680 D-loop; other site 471854015681 H-loop/switch region; other site 471854015682 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 471854015683 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471854015684 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 471854015685 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471854015686 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 471854015687 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471854015688 dimer interface [polypeptide binding]; other site 471854015689 active site 471854015690 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 471854015691 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 471854015692 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 471854015693 active site 471854015694 substrate binding site [chemical binding]; other site 471854015695 coenzyme B12 binding site [chemical binding]; other site 471854015696 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 471854015697 B12 binding site [chemical binding]; other site 471854015698 cobalt ligand [ion binding]; other site