-- dump date 20140619_065840 -- class Genbank::misc_feature -- table misc_feature_note -- id note 926556000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 926556000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 926556000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556000004 Walker A motif; other site 926556000005 ATP binding site [chemical binding]; other site 926556000006 Walker B motif; other site 926556000007 arginine finger; other site 926556000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 926556000009 DnaA box-binding interface [nucleotide binding]; other site 926556000010 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 926556000011 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 926556000012 membrane ATPase/protein kinase; Provisional; Region: PRK09435 926556000013 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 926556000014 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 926556000015 Walker A; other site 926556000016 G1 box; other site 926556000017 GTP/Mg2+ binding site [chemical binding]; other site 926556000018 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 926556000019 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 926556000020 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 926556000021 Cu(I) binding site [ion binding]; other site 926556000022 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 926556000023 Cytochrome c; Region: Cytochrom_C; pfam00034 926556000024 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 926556000025 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 926556000026 homodimer interface [polypeptide binding]; other site 926556000027 substrate-cofactor binding pocket; other site 926556000028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556000029 catalytic residue [active] 926556000030 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926556000031 FtsX-like permease family; Region: FtsX; pfam02687 926556000032 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926556000033 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926556000034 Walker A/P-loop; other site 926556000035 ATP binding site [chemical binding]; other site 926556000036 Q-loop/lid; other site 926556000037 ABC transporter signature motif; other site 926556000038 Walker B; other site 926556000039 D-loop; other site 926556000040 H-loop/switch region; other site 926556000041 Response regulator receiver domain; Region: Response_reg; pfam00072 926556000042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556000043 active site 926556000044 phosphorylation site [posttranslational modification] 926556000045 intermolecular recognition site; other site 926556000046 dimerization interface [polypeptide binding]; other site 926556000047 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556000048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556000049 dimer interface [polypeptide binding]; other site 926556000050 phosphorylation site [posttranslational modification] 926556000051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556000052 ATP binding site [chemical binding]; other site 926556000053 Mg2+ binding site [ion binding]; other site 926556000054 G-X-G motif; other site 926556000055 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 926556000056 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 926556000057 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556000058 putative active site [active] 926556000059 heme pocket [chemical binding]; other site 926556000060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556000061 dimer interface [polypeptide binding]; other site 926556000062 phosphorylation site [posttranslational modification] 926556000063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556000064 ATP binding site [chemical binding]; other site 926556000065 Mg2+ binding site [ion binding]; other site 926556000066 G-X-G motif; other site 926556000067 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 926556000068 CoA binding domain; Region: CoA_binding; smart00881 926556000069 CoA-ligase; Region: Ligase_CoA; pfam00549 926556000070 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 926556000071 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926556000072 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926556000073 ligand binding site [chemical binding]; other site 926556000074 phosphodiesterase; Provisional; Region: PRK12704 926556000075 KH domain; Region: KH_1; pfam00013 926556000076 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926556000077 Zn2+ binding site [ion binding]; other site 926556000078 Mg2+ binding site [ion binding]; other site 926556000079 Cell division protein ZapA; Region: ZapA; pfam05164 926556000080 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 926556000081 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 926556000082 putative tRNA-binding site [nucleotide binding]; other site 926556000083 B3/4 domain; Region: B3_4; pfam03483 926556000084 tRNA synthetase B5 domain; Region: B5; smart00874 926556000085 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 926556000086 dimer interface [polypeptide binding]; other site 926556000087 motif 1; other site 926556000088 motif 3; other site 926556000089 motif 2; other site 926556000090 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 926556000091 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 926556000092 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 926556000093 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 926556000094 Int/Topo IB signature motif; other site 926556000095 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926556000096 active site 926556000097 DNA binding site [nucleotide binding] 926556000098 Int/Topo IB signature motif; other site 926556000099 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 926556000100 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926556000101 active site 926556000102 DNA binding site [nucleotide binding] 926556000103 Int/Topo IB signature motif; other site 926556000104 hypothetical protein; Reviewed; Region: PRK00024 926556000105 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 926556000106 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 926556000107 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981 926556000108 Zn binding site [ion binding]; other site 926556000109 alanine aminotransferase; Validated; Region: PRK08363 926556000110 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926556000111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556000112 homodimer interface [polypeptide binding]; other site 926556000113 catalytic residue [active] 926556000114 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 926556000115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556000116 Walker A/P-loop; other site 926556000117 ATP binding site [chemical binding]; other site 926556000118 Q-loop/lid; other site 926556000119 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926556000120 ABC transporter; Region: ABC_tran_2; pfam12848 926556000121 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926556000122 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 926556000123 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 926556000124 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 926556000125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556000126 Response regulator receiver domain; Region: Response_reg; pfam00072 926556000127 active site 926556000128 phosphorylation site [posttranslational modification] 926556000129 intermolecular recognition site; other site 926556000130 dimerization interface [polypeptide binding]; other site 926556000131 LytTr DNA-binding domain; Region: LytTR; smart00850 926556000132 Histidine kinase; Region: His_kinase; pfam06580 926556000133 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 926556000134 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 926556000135 substrate binding site; other site 926556000136 dimer interface; other site 926556000137 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 926556000138 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 926556000139 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926556000140 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 926556000141 FtsX-like permease family; Region: FtsX; pfam02687 926556000142 recombinase A; Provisional; Region: recA; PRK09354 926556000143 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 926556000144 hexamer interface [polypeptide binding]; other site 926556000145 Walker A motif; other site 926556000146 ATP binding site [chemical binding]; other site 926556000147 Walker B motif; other site 926556000148 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 926556000149 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926556000150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556000151 active site 926556000152 phosphorylation site [posttranslational modification] 926556000153 intermolecular recognition site; other site 926556000154 dimerization interface [polypeptide binding]; other site 926556000155 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926556000156 DNA binding site [nucleotide binding] 926556000157 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556000158 dimer interface [polypeptide binding]; other site 926556000159 phosphorylation site [posttranslational modification] 926556000160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556000161 ATP binding site [chemical binding]; other site 926556000162 Mg2+ binding site [ion binding]; other site 926556000163 G-X-G motif; other site 926556000164 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 926556000165 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 926556000166 active site 926556000167 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 926556000168 23S rRNA interface [nucleotide binding]; other site 926556000169 L3 interface [polypeptide binding]; other site 926556000170 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 926556000171 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 926556000172 rRNA interaction site [nucleotide binding]; other site 926556000173 S8 interaction site; other site 926556000174 putative laminin-1 binding site; other site 926556000175 elongation factor Ts; Provisional; Region: tsf; PRK09377 926556000176 UBA/TS-N domain; Region: UBA; pfam00627 926556000177 Elongation factor TS; Region: EF_TS; pfam00889 926556000178 Elongation factor TS; Region: EF_TS; pfam00889 926556000179 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 926556000180 proline aminopeptidase P II; Provisional; Region: PRK10879 926556000181 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 926556000182 active site 926556000183 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926556000184 active site 926556000185 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 926556000186 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 926556000187 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 926556000188 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 926556000189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556000190 S-adenosylmethionine binding site [chemical binding]; other site 926556000191 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 926556000192 N-acetyl-D-glucosamine binding site [chemical binding]; other site 926556000193 catalytic residue [active] 926556000194 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926556000195 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926556000196 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 926556000197 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 926556000198 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 926556000199 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 926556000200 NAD(P) binding site [chemical binding]; other site 926556000201 homodimer interface [polypeptide binding]; other site 926556000202 substrate binding site [chemical binding]; other site 926556000203 active site 926556000204 Bacterial sugar transferase; Region: Bac_transf; pfam02397 926556000205 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 926556000206 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 926556000207 inhibitor-cofactor binding pocket; inhibition site 926556000208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556000209 catalytic residue [active] 926556000210 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 926556000211 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 926556000212 Mg++ binding site [ion binding]; other site 926556000213 putative catalytic motif [active] 926556000214 substrate binding site [chemical binding]; other site 926556000215 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926556000216 enoyl-CoA hydratase; Provisional; Region: PRK08140 926556000217 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 926556000218 substrate binding site [chemical binding]; other site 926556000219 oxyanion hole (OAH) forming residues; other site 926556000220 trimer interface [polypeptide binding]; other site 926556000221 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 926556000222 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 926556000223 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 926556000224 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 926556000225 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 926556000226 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 926556000227 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 926556000228 putative dimer interface [polypeptide binding]; other site 926556000229 putative anticodon binding site; other site 926556000230 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 926556000231 homodimer interface [polypeptide binding]; other site 926556000232 motif 1; other site 926556000233 motif 2; other site 926556000234 active site 926556000235 motif 3; other site 926556000236 putative carbohydrate kinase; Provisional; Region: PRK10565 926556000237 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 926556000238 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 926556000239 putative substrate binding site [chemical binding]; other site 926556000240 putative ATP binding site [chemical binding]; other site 926556000241 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 926556000242 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 926556000243 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 926556000244 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 926556000245 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 926556000246 active site 926556000247 homodimer interface [polypeptide binding]; other site 926556000248 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 926556000249 active site 926556000250 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926556000251 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926556000252 active site 926556000253 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 926556000254 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 926556000255 NodB motif; other site 926556000256 active site 926556000257 catalytic site [active] 926556000258 metal binding site [ion binding]; metal-binding site 926556000259 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 926556000260 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 926556000261 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926556000262 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926556000263 active site 926556000264 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 926556000265 active site 926556000266 putative DNA-binding cleft [nucleotide binding]; other site 926556000267 dimer interface [polypeptide binding]; other site 926556000268 thiamine monophosphate kinase; Provisional; Region: PRK05731 926556000269 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 926556000270 ATP binding site [chemical binding]; other site 926556000271 dimerization interface [polypeptide binding]; other site 926556000272 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926556000273 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 926556000274 dimer interface [polypeptide binding]; other site 926556000275 substrate binding site [chemical binding]; other site 926556000276 metal binding site [ion binding]; metal-binding site 926556000277 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 926556000278 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 926556000279 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 926556000280 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 926556000281 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 926556000282 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 926556000283 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 926556000284 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926556000285 catalytic residue [active] 926556000286 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 926556000287 AAA domain; Region: AAA_26; pfam13500 926556000288 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 926556000289 active site 926556000290 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 926556000291 homodimer interface [polypeptide binding]; other site 926556000292 metal binding site [ion binding]; metal-binding site 926556000293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556000294 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 926556000295 Walker A/P-loop; other site 926556000296 ATP binding site [chemical binding]; other site 926556000297 Q-loop/lid; other site 926556000298 ABC transporter signature motif; other site 926556000299 Walker B; other site 926556000300 D-loop; other site 926556000301 H-loop/switch region; other site 926556000302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 926556000303 Walker A/P-loop; other site 926556000304 ATP binding site [chemical binding]; other site 926556000305 Q-loop/lid; other site 926556000306 ABC transporter signature motif; other site 926556000307 Walker B; other site 926556000308 D-loop; other site 926556000309 H-loop/switch region; other site 926556000310 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 926556000311 putative active site [active] 926556000312 dimerization interface [polypeptide binding]; other site 926556000313 putative tRNAtyr binding site [nucleotide binding]; other site 926556000314 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 926556000315 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 926556000316 NAD binding site [chemical binding]; other site 926556000317 active site 926556000318 Uncharacterized conserved protein [Function unknown]; Region: COG3339 926556000319 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 926556000320 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 926556000321 Dihydroneopterin aldolase; Region: FolB; pfam02152 926556000322 active site 926556000323 DivIVA protein; Region: DivIVA; pfam05103 926556000324 DivIVA domain; Region: DivI1A_domain; TIGR03544 926556000325 FOG: WD40 repeat [General function prediction only]; Region: COG2319 926556000326 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 926556000327 structural tetrad; other site 926556000328 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 926556000329 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 926556000330 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 926556000331 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556000332 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 926556000333 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 926556000334 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 926556000335 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 926556000336 active site 926556000337 metal binding site [ion binding]; metal-binding site 926556000338 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 926556000339 Amidinotransferase; Region: Amidinotransf; cl12043 926556000340 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 926556000341 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 926556000342 active site 926556000343 Zn binding site [ion binding]; other site 926556000344 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 926556000345 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 926556000346 dimer interface [polypeptide binding]; other site 926556000347 putative anticodon binding site; other site 926556000348 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 926556000349 motif 1; other site 926556000350 active site 926556000351 motif 2; other site 926556000352 motif 3; other site 926556000353 proline dehydrogenase; Region: PLN02681 926556000354 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 926556000355 Chorismate mutase type II; Region: CM_2; smart00830 926556000356 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 926556000357 active site 926556000358 dimer interface [polypeptide binding]; other site 926556000359 metal binding site [ion binding]; metal-binding site 926556000360 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 926556000361 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 926556000362 hinge; other site 926556000363 active site 926556000364 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 926556000365 Prephenate dehydratase; Region: PDT; pfam00800 926556000366 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 926556000367 putative L-Phe binding site [chemical binding]; other site 926556000368 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 926556000369 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926556000370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556000371 homodimer interface [polypeptide binding]; other site 926556000372 catalytic residue [active] 926556000373 Prephenate dehydrogenase; Region: PDH; pfam02153 926556000374 prephenate dehydrogenase; Validated; Region: PRK08507 926556000375 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 926556000376 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 926556000377 intersubunit interface [polypeptide binding]; other site 926556000378 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 926556000379 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 926556000380 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 926556000381 active site 926556000382 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 926556000383 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 926556000384 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 926556000385 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 926556000386 tRNA; other site 926556000387 putative tRNA binding site [nucleotide binding]; other site 926556000388 putative NADP binding site [chemical binding]; other site 926556000389 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 926556000390 hypothetical protein; Provisional; Region: PRK13665 926556000391 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 926556000392 prolyl-tRNA synthetase; Provisional; Region: PRK08661 926556000393 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 926556000394 dimer interface [polypeptide binding]; other site 926556000395 motif 1; other site 926556000396 active site 926556000397 motif 2; other site 926556000398 motif 3; other site 926556000399 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 926556000400 anticodon binding site; other site 926556000401 zinc-binding site [ion binding]; other site 926556000402 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 926556000403 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 926556000404 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 926556000405 ADP binding site [chemical binding]; other site 926556000406 magnesium binding site [ion binding]; other site 926556000407 putative shikimate binding site; other site 926556000408 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 926556000409 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 926556000410 dihydropteroate synthase; Region: DHPS; TIGR01496 926556000411 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 926556000412 substrate binding pocket [chemical binding]; other site 926556000413 dimer interface [polypeptide binding]; other site 926556000414 inhibitor binding site; inhibition site 926556000415 Uncharacterized conserved protein [Function unknown]; Region: COG1624 926556000416 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 926556000417 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 926556000418 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 926556000419 substrate-cofactor binding pocket; other site 926556000420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556000421 catalytic residue [active] 926556000422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926556000423 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926556000424 NAD(P) binding site [chemical binding]; other site 926556000425 active site 926556000426 NlpE N-terminal domain; Region: NlpE; pfam04170 926556000427 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 926556000428 ArsC family; Region: ArsC; pfam03960 926556000429 putative catalytic residues [active] 926556000430 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 926556000431 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 926556000432 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 926556000433 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 926556000434 inhibitor-cofactor binding pocket; inhibition site 926556000435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556000436 catalytic residue [active] 926556000437 Tetratricopeptide repeat; Region: TPR_18; pfam13512 926556000438 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 926556000439 ligand binding site [chemical binding]; other site 926556000440 GMP synthase; Reviewed; Region: guaA; PRK00074 926556000441 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 926556000442 AMP/PPi binding site [chemical binding]; other site 926556000443 candidate oxyanion hole; other site 926556000444 catalytic triad [active] 926556000445 potential glutamine specificity residues [chemical binding]; other site 926556000446 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 926556000447 ATP Binding subdomain [chemical binding]; other site 926556000448 Ligand Binding sites [chemical binding]; other site 926556000449 Dimerization subdomain; other site 926556000450 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556000451 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556000452 Amidohydrolase; Region: Amidohydro_2; pfam04909 926556000453 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 926556000454 intersubunit interface [polypeptide binding]; other site 926556000455 active site 926556000456 zinc binding site [ion binding]; other site 926556000457 Na+ binding site [ion binding]; other site 926556000458 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 926556000459 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 926556000460 substrate binding site [chemical binding]; other site 926556000461 ATP binding site [chemical binding]; other site 926556000462 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 926556000463 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 926556000464 putative substrate binding site [chemical binding]; other site 926556000465 putative ATP binding site [chemical binding]; other site 926556000466 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 926556000467 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 926556000468 dimer interface [polypeptide binding]; other site 926556000469 active site 926556000470 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 926556000471 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 926556000472 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 926556000473 oligomer interface [polypeptide binding]; other site 926556000474 active site 926556000475 metal binding site [ion binding]; metal-binding site 926556000476 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 926556000477 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 926556000478 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 926556000479 exopolyphosphatase; Region: exo_poly_only; TIGR03706 926556000480 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 926556000481 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 926556000482 OsmC-like protein; Region: OsmC; cl00767 926556000483 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 926556000484 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 926556000485 Substrate binding site; other site 926556000486 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 926556000487 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 926556000488 putative active site [active] 926556000489 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 926556000490 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 926556000491 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926556000492 ATP binding site [chemical binding]; other site 926556000493 putative Mg++ binding site [ion binding]; other site 926556000494 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926556000495 nucleotide binding region [chemical binding]; other site 926556000496 ATP-binding site [chemical binding]; other site 926556000497 RQC domain; Region: RQC; pfam09382 926556000498 HRDC domain; Region: HRDC; pfam00570 926556000499 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 926556000500 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 926556000501 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 926556000502 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 926556000503 PSP1 C-terminal conserved region; Region: PSP1; cl00770 926556000504 GldH lipoprotein; Region: GldH_lipo; cl11905 926556000505 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 926556000506 AAA domain; Region: AAA_11; pfam13086 926556000507 Part of AAA domain; Region: AAA_19; pfam13245 926556000508 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 926556000509 AAA domain; Region: AAA_12; pfam13087 926556000510 short chain dehydrogenase; Provisional; Region: PRK06181 926556000511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926556000512 NAD(P) binding site [chemical binding]; other site 926556000513 active site 926556000514 TRAM domain; Region: TRAM; pfam01938 926556000515 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 926556000516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556000517 S-adenosylmethionine binding site [chemical binding]; other site 926556000518 Domain of unknown function DUF11; Region: DUF11; pfam01345 926556000519 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926556000520 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926556000521 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926556000522 ligand binding site [chemical binding]; other site 926556000523 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 926556000524 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 926556000525 nucleotide binding site/active site [active] 926556000526 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 926556000527 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 926556000528 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 926556000529 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 926556000530 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179 926556000531 putative ligand binding site [chemical binding]; other site 926556000532 putative NAD binding site [chemical binding]; other site 926556000533 catalytic site [active] 926556000534 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 926556000535 MgtE intracellular N domain; Region: MgtE_N; pfam03448 926556000536 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 926556000537 Divalent cation transporter; Region: MgtE; pfam01769 926556000538 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 926556000539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556000540 S-adenosylmethionine binding site [chemical binding]; other site 926556000541 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 926556000542 interface (dimer of trimers) [polypeptide binding]; other site 926556000543 Substrate-binding/catalytic site; other site 926556000544 Zn-binding sites [ion binding]; other site 926556000545 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 926556000546 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 926556000547 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 926556000548 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 926556000549 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 926556000550 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 926556000551 dimer interface [polypeptide binding]; other site 926556000552 active site 926556000553 CoA binding pocket [chemical binding]; other site 926556000554 elongation factor P; Validated; Region: PRK00529 926556000555 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 926556000556 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 926556000557 RNA binding site [nucleotide binding]; other site 926556000558 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 926556000559 RNA binding site [nucleotide binding]; other site 926556000560 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 926556000561 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 926556000562 carboxyltransferase (CT) interaction site; other site 926556000563 biotinylation site [posttranslational modification]; other site 926556000564 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 926556000565 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 926556000566 ATP-grasp domain; Region: ATP-grasp_4; cl17255 926556000567 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 926556000568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926556000569 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926556000570 NAD(P) binding site [chemical binding]; other site 926556000571 active site 926556000572 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 926556000573 Response regulator receiver domain; Region: Response_reg; pfam00072 926556000574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556000575 active site 926556000576 phosphorylation site [posttranslational modification] 926556000577 intermolecular recognition site; other site 926556000578 dimerization interface [polypeptide binding]; other site 926556000579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556000580 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 926556000581 Walker A motif; other site 926556000582 ATP binding site [chemical binding]; other site 926556000583 Walker B motif; other site 926556000584 arginine finger; other site 926556000585 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 926556000586 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 926556000587 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 926556000588 tetramer interface [polypeptide binding]; other site 926556000589 TPP-binding site [chemical binding]; other site 926556000590 heterodimer interface [polypeptide binding]; other site 926556000591 phosphorylation loop region [posttranslational modification] 926556000592 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 926556000593 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 926556000594 PYR/PP interface [polypeptide binding]; other site 926556000595 dimer interface [polypeptide binding]; other site 926556000596 TPP binding site [chemical binding]; other site 926556000597 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 926556000598 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 926556000599 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 926556000600 hexamer interface [polypeptide binding]; other site 926556000601 ligand binding site [chemical binding]; other site 926556000602 putative active site [active] 926556000603 NAD(P) binding site [chemical binding]; other site 926556000604 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 926556000605 active sites [active] 926556000606 tetramer interface [polypeptide binding]; other site 926556000607 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 926556000608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 926556000609 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 926556000610 dimerization interface [polypeptide binding]; other site 926556000611 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 926556000612 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 926556000613 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 926556000614 active site 926556000615 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 926556000616 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 926556000617 putative catalytic site [active] 926556000618 putative metal binding site [ion binding]; other site 926556000619 putative phosphate binding site [ion binding]; other site 926556000620 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 926556000621 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926556000622 putative DNA binding site [nucleotide binding]; other site 926556000623 putative Zn2+ binding site [ion binding]; other site 926556000624 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 926556000625 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 926556000626 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926556000627 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 926556000628 Fasciclin domain; Region: Fasciclin; pfam02469 926556000629 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 926556000630 Fasciclin domain; Region: Fasciclin; pfam02469 926556000631 sulfite oxidase; Provisional; Region: PLN00177 926556000632 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 926556000633 Moco binding site; other site 926556000634 metal coordination site [ion binding]; other site 926556000635 dimerization interface [polypeptide binding]; other site 926556000636 Putative transcription activator [Transcription]; Region: TenA; COG0819 926556000637 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 926556000638 substrate binding site [chemical binding]; other site 926556000639 dimer interface [polypeptide binding]; other site 926556000640 ATP binding site [chemical binding]; other site 926556000641 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 926556000642 thiamine phosphate binding site [chemical binding]; other site 926556000643 active site 926556000644 pyrophosphate binding site [ion binding]; other site 926556000645 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 926556000646 substrate binding site [chemical binding]; other site 926556000647 multimerization interface [polypeptide binding]; other site 926556000648 ATP binding site [chemical binding]; other site 926556000649 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 926556000650 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 926556000651 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 926556000652 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 926556000653 dimer interface [polypeptide binding]; other site 926556000654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556000655 catalytic residue [active] 926556000656 serine O-acetyltransferase; Region: cysE; TIGR01172 926556000657 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 926556000658 trimer interface [polypeptide binding]; other site 926556000659 active site 926556000660 substrate binding site [chemical binding]; other site 926556000661 CoA binding site [chemical binding]; other site 926556000662 enolase; Provisional; Region: eno; PRK00077 926556000663 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 926556000664 dimer interface [polypeptide binding]; other site 926556000665 metal binding site [ion binding]; metal-binding site 926556000666 substrate binding pocket [chemical binding]; other site 926556000667 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 926556000668 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 926556000669 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 926556000670 catalytic site [active] 926556000671 subunit interface [polypeptide binding]; other site 926556000672 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 926556000673 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 926556000674 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 926556000675 alphaNTD - beta interaction site [polypeptide binding]; other site 926556000676 alphaNTD homodimer interface [polypeptide binding]; other site 926556000677 alphaNTD - beta' interaction site [polypeptide binding]; other site 926556000678 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 926556000679 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 926556000680 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 926556000681 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 926556000682 RNA binding surface [nucleotide binding]; other site 926556000683 30S ribosomal protein S11; Validated; Region: PRK05309 926556000684 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 926556000685 30S ribosomal protein S13; Region: bact_S13; TIGR03631 926556000686 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 926556000687 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 926556000688 rRNA binding site [nucleotide binding]; other site 926556000689 predicted 30S ribosome binding site; other site 926556000690 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 926556000691 active site 926556000692 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 926556000693 SecY translocase; Region: SecY; pfam00344 926556000694 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 926556000695 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 926556000696 23S rRNA binding site [nucleotide binding]; other site 926556000697 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 926556000698 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 926556000699 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 926556000700 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 926556000701 5S rRNA interface [nucleotide binding]; other site 926556000702 23S rRNA interface [nucleotide binding]; other site 926556000703 L5 interface [polypeptide binding]; other site 926556000704 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 926556000705 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 926556000706 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 926556000707 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 926556000708 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 926556000709 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 926556000710 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 926556000711 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 926556000712 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 926556000713 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 926556000714 RNA binding site [nucleotide binding]; other site 926556000715 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 926556000716 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 926556000717 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 926556000718 L23 interface [polypeptide binding]; other site 926556000719 signal recognition particle (SRP54) interaction site; other site 926556000720 trigger factor interaction site; other site 926556000721 23S rRNA interface [nucleotide binding]; other site 926556000722 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 926556000723 23S rRNA interface [nucleotide binding]; other site 926556000724 5S rRNA interface [nucleotide binding]; other site 926556000725 putative antibiotic binding site [chemical binding]; other site 926556000726 L25 interface [polypeptide binding]; other site 926556000727 L27 interface [polypeptide binding]; other site 926556000728 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 926556000729 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 926556000730 G-X-X-G motif; other site 926556000731 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 926556000732 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 926556000733 putative translocon binding site; other site 926556000734 protein-rRNA interface [nucleotide binding]; other site 926556000735 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 926556000736 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 926556000737 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 926556000738 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 926556000739 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 926556000740 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 926556000741 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 926556000742 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 926556000743 elongation factor G; Reviewed; Region: PRK12739 926556000744 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 926556000745 G1 box; other site 926556000746 putative GEF interaction site [polypeptide binding]; other site 926556000747 GTP/Mg2+ binding site [chemical binding]; other site 926556000748 Switch I region; other site 926556000749 G2 box; other site 926556000750 G3 box; other site 926556000751 Switch II region; other site 926556000752 G4 box; other site 926556000753 G5 box; other site 926556000754 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 926556000755 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 926556000756 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 926556000757 30S ribosomal protein S7; Validated; Region: PRK05302 926556000758 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 926556000759 S17 interaction site [polypeptide binding]; other site 926556000760 S8 interaction site; other site 926556000761 16S rRNA interaction site [nucleotide binding]; other site 926556000762 streptomycin interaction site [chemical binding]; other site 926556000763 23S rRNA interaction site [nucleotide binding]; other site 926556000764 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 926556000765 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 926556000766 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 926556000767 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 926556000768 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 926556000769 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 926556000770 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 926556000771 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 926556000772 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 926556000773 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 926556000774 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 926556000775 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 926556000776 DNA binding site [nucleotide binding] 926556000777 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 926556000778 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 926556000779 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 926556000780 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 926556000781 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 926556000782 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 926556000783 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 926556000784 RPB12 interaction site [polypeptide binding]; other site 926556000785 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 926556000786 RPB3 interaction site [polypeptide binding]; other site 926556000787 RPB1 interaction site [polypeptide binding]; other site 926556000788 RPB11 interaction site [polypeptide binding]; other site 926556000789 RPB10 interaction site [polypeptide binding]; other site 926556000790 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 926556000791 core dimer interface [polypeptide binding]; other site 926556000792 peripheral dimer interface [polypeptide binding]; other site 926556000793 L10 interface [polypeptide binding]; other site 926556000794 L11 interface [polypeptide binding]; other site 926556000795 putative EF-Tu interaction site [polypeptide binding]; other site 926556000796 putative EF-G interaction site [polypeptide binding]; other site 926556000797 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 926556000798 23S rRNA interface [nucleotide binding]; other site 926556000799 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 926556000800 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 926556000801 mRNA/rRNA interface [nucleotide binding]; other site 926556000802 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 926556000803 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 926556000804 23S rRNA interface [nucleotide binding]; other site 926556000805 L7/L12 interface [polypeptide binding]; other site 926556000806 putative thiostrepton binding site; other site 926556000807 L25 interface [polypeptide binding]; other site 926556000808 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 926556000809 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 926556000810 putative homodimer interface [polypeptide binding]; other site 926556000811 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 926556000812 heterodimer interface [polypeptide binding]; other site 926556000813 homodimer interface [polypeptide binding]; other site 926556000814 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 926556000815 elongation factor Tu; Reviewed; Region: PRK12735 926556000816 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 926556000817 G1 box; other site 926556000818 GEF interaction site [polypeptide binding]; other site 926556000819 GTP/Mg2+ binding site [chemical binding]; other site 926556000820 Switch I region; other site 926556000821 G2 box; other site 926556000822 G3 box; other site 926556000823 Switch II region; other site 926556000824 G4 box; other site 926556000825 G5 box; other site 926556000826 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 926556000827 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 926556000828 Antibiotic Binding Site [chemical binding]; other site 926556000829 Peptidase family M1; Region: Peptidase_M1; pfam01433 926556000830 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 926556000831 Zn binding site [ion binding]; other site 926556000832 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 926556000833 carboxyltransferase (CT) interaction site; other site 926556000834 biotinylation site [posttranslational modification]; other site 926556000835 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 926556000836 putative nucleotide binding site [chemical binding]; other site 926556000837 uridine monophosphate binding site [chemical binding]; other site 926556000838 homohexameric interface [polypeptide binding]; other site 926556000839 ribosome recycling factor; Reviewed; Region: frr; PRK00083 926556000840 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 926556000841 hinge region; other site 926556000842 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556000843 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556000844 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556000845 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556000846 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556000847 SusD family; Region: SusD; pfam07980 926556000848 Family description; Region: VCBS; pfam13517 926556000849 Family description; Region: VCBS; pfam13517 926556000850 Family description; Region: VCBS; pfam13517 926556000851 Family description; Region: VCBS; pfam13517 926556000852 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 926556000853 Family description; Region: VCBS; pfam13517 926556000854 Family description; Region: VCBS; pfam13517 926556000855 Family description; Region: VCBS; pfam13517 926556000856 Family description; Region: VCBS; pfam13517 926556000857 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 926556000858 active site 926556000859 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 926556000860 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 926556000861 active site 926556000862 (T/H)XGH motif; other site 926556000863 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 926556000864 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 926556000865 catalytic site [active] 926556000866 G-X2-G-X-G-K; other site 926556000867 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 926556000868 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 926556000869 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556000870 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556000871 DNA binding residues [nucleotide binding] 926556000872 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 926556000873 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 926556000874 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 926556000875 putative acyl-acceptor binding pocket; other site 926556000876 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 926556000877 Part of AAA domain; Region: AAA_19; pfam13245 926556000878 Family description; Region: UvrD_C_2; pfam13538 926556000879 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 926556000880 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 926556000881 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 926556000882 hinge; other site 926556000883 active site 926556000884 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 926556000885 DNA polymerase III subunit beta; Validated; Region: PRK05643 926556000886 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 926556000887 putative DNA binding surface [nucleotide binding]; other site 926556000888 dimer interface [polypeptide binding]; other site 926556000889 beta-clamp/clamp loader binding surface; other site 926556000890 beta-clamp/translesion DNA polymerase binding surface; other site 926556000891 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 926556000892 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 926556000893 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 926556000894 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 926556000895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556000896 Walker A/P-loop; other site 926556000897 ATP binding site [chemical binding]; other site 926556000898 Q-loop/lid; other site 926556000899 ABC transporter signature motif; other site 926556000900 Walker B; other site 926556000901 D-loop; other site 926556000902 H-loop/switch region; other site 926556000903 short chain dehydrogenase; Provisional; Region: PRK07326 926556000904 classical (c) SDRs; Region: SDR_c; cd05233 926556000905 NAD(P) binding site [chemical binding]; other site 926556000906 active site 926556000907 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667 926556000908 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 926556000909 metal binding site [ion binding]; metal-binding site 926556000910 putative dimer interface [polypeptide binding]; other site 926556000911 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 926556000912 Ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding domain of the alpha/beta class and a discrete (usually N-terminal) domain which varies in orientation with respect to the NAD(P) binding domain. The N-terminal region...; Region: FNR_like_1; cd06196 926556000913 FAD binding pocket [chemical binding]; other site 926556000914 FAD binding motif [chemical binding]; other site 926556000915 phosphate binding motif [ion binding]; other site 926556000916 beta-alpha-beta structure motif; other site 926556000917 NAD binding pocket [chemical binding]; other site 926556000918 purine nucleoside phosphorylase; Provisional; Region: PRK08202 926556000919 Predicted flavoprotein [General function prediction only]; Region: COG0431 926556000920 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 926556000921 cell division protein FtsZ; Validated; Region: PRK09330 926556000922 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 926556000923 nucleotide binding site [chemical binding]; other site 926556000924 SulA interaction site; other site 926556000925 cell division protein FtsA; Region: ftsA; TIGR01174 926556000926 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926556000927 nucleotide binding site [chemical binding]; other site 926556000928 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 926556000929 Cell division protein FtsA; Region: FtsA; pfam14450 926556000930 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 926556000931 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926556000932 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 926556000933 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 926556000934 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 926556000935 active site 926556000936 homodimer interface [polypeptide binding]; other site 926556000937 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 926556000938 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 926556000939 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 926556000940 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926556000941 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 926556000942 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 926556000943 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 926556000944 Mg++ binding site [ion binding]; other site 926556000945 putative catalytic motif [active] 926556000946 putative substrate binding site [chemical binding]; other site 926556000947 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 926556000948 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 926556000949 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926556000950 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 926556000951 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 926556000952 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 926556000953 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 926556000954 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 926556000955 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 926556000956 MraW methylase family; Region: Methyltransf_5; cl17771 926556000957 cell division protein MraZ; Reviewed; Region: PRK00326 926556000958 MraZ protein; Region: MraZ; pfam02381 926556000959 MraZ protein; Region: MraZ; pfam02381 926556000960 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 926556000961 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 926556000962 substrate binding pocket [chemical binding]; other site 926556000963 chain length determination region; other site 926556000964 substrate-Mg2+ binding site; other site 926556000965 catalytic residues [active] 926556000966 aspartate-rich region 1; other site 926556000967 active site lid residues [active] 926556000968 aspartate-rich region 2; other site 926556000969 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 926556000970 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 926556000971 putative acyl-acceptor binding pocket; other site 926556000972 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 926556000973 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 926556000974 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 926556000975 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 926556000976 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 926556000977 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 926556000978 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 926556000979 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556000980 non-specific DNA binding site [nucleotide binding]; other site 926556000981 salt bridge; other site 926556000982 sequence-specific DNA binding site [nucleotide binding]; other site 926556000983 Protein of unknown function DUF262; Region: DUF262; pfam03235 926556000984 Uncharacterized conserved protein [Function unknown]; Region: COG5476 926556000985 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 926556000986 MlrC C-terminus; Region: MlrC_C; pfam07171 926556000987 Peptidase family M48; Region: Peptidase_M48; pfam01435 926556000988 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 926556000989 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 926556000990 hypothetical protein; Validated; Region: PRK02101 926556000991 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 926556000992 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 926556000993 Phosphoglycerate kinase; Region: PGK; pfam00162 926556000994 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 926556000995 substrate binding site [chemical binding]; other site 926556000996 hinge regions; other site 926556000997 ADP binding site [chemical binding]; other site 926556000998 catalytic site [active] 926556000999 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 926556001000 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 926556001001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556001002 binding surface 926556001003 TPR repeat; Region: TPR_11; pfam13414 926556001004 TPR motif; other site 926556001005 TPR repeat; Region: TPR_11; pfam13414 926556001006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556001007 TPR repeat; Region: TPR_11; pfam13414 926556001008 binding surface 926556001009 TPR motif; other site 926556001010 Tetratricopeptide repeat; Region: TPR_16; pfam13432 926556001011 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 926556001012 nudix motif; other site 926556001013 DEAD-like helicases superfamily; Region: DEXDc; smart00487 926556001014 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926556001015 ATP binding site [chemical binding]; other site 926556001016 putative Mg++ binding site [ion binding]; other site 926556001017 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926556001018 nucleotide binding region [chemical binding]; other site 926556001019 ATP-binding site [chemical binding]; other site 926556001020 enoyl-CoA hydratase; Provisional; Region: PRK05995 926556001021 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 926556001022 substrate binding site [chemical binding]; other site 926556001023 oxyanion hole (OAH) forming residues; other site 926556001024 trimer interface [polypeptide binding]; other site 926556001025 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 926556001026 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 926556001027 Competence protein; Region: Competence; pfam03772 926556001028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926556001029 Coenzyme A binding pocket [chemical binding]; other site 926556001030 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 926556001031 PhoH-like protein; Region: PhoH; pfam02562 926556001032 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 926556001033 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926556001034 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556001035 catalytic residues [active] 926556001036 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 926556001037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556001038 non-specific DNA binding site [nucleotide binding]; other site 926556001039 salt bridge; other site 926556001040 sequence-specific DNA binding site [nucleotide binding]; other site 926556001041 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 926556001042 active site 926556001043 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 926556001044 Predicted transcriptional regulators [Transcription]; Region: COG1695 926556001045 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 926556001046 PspC domain; Region: PspC; pfam04024 926556001047 PspC domain; Region: PspC; pfam04024 926556001048 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 926556001049 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 926556001050 Beta-Casp domain; Region: Beta-Casp; smart01027 926556001051 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 926556001052 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926556001053 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556001054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556001055 DNA binding residues [nucleotide binding] 926556001056 Peroxin 13, N-terminal region; Region: Peroxin-13_N; pfam04088 926556001057 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926556001058 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 926556001059 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 926556001060 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 926556001061 FAD binding pocket [chemical binding]; other site 926556001062 FAD binding motif [chemical binding]; other site 926556001063 phosphate binding motif [ion binding]; other site 926556001064 beta-alpha-beta structure motif; other site 926556001065 NAD(p) ribose binding residues [chemical binding]; other site 926556001066 NAD binding pocket [chemical binding]; other site 926556001067 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 926556001068 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 926556001069 catalytic loop [active] 926556001070 iron binding site [ion binding]; other site 926556001071 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 926556001072 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 926556001073 adenylosuccinate lyase; Provisional; Region: PRK09285 926556001074 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 926556001075 tetramer interface [polypeptide binding]; other site 926556001076 active site 926556001077 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 926556001078 Amidinotransferase; Region: Amidinotransf; pfam02274 926556001079 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 926556001080 Clp amino terminal domain; Region: Clp_N; pfam02861 926556001081 Clp amino terminal domain; Region: Clp_N; pfam02861 926556001082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556001083 Walker A motif; other site 926556001084 ATP binding site [chemical binding]; other site 926556001085 Walker B motif; other site 926556001086 arginine finger; other site 926556001087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556001088 Walker A motif; other site 926556001089 ATP binding site [chemical binding]; other site 926556001090 Walker B motif; other site 926556001091 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 926556001092 WbqC-like protein family; Region: WbqC; pfam08889 926556001093 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 926556001094 YceG-like family; Region: YceG; pfam02618 926556001095 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 926556001096 dimerization interface [polypeptide binding]; other site 926556001097 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 926556001098 active site 926556001099 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 926556001100 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 926556001101 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 926556001102 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926556001103 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 926556001104 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 926556001105 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 926556001106 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 926556001107 HsdM N-terminal domain; Region: HsdM_N; pfam12161 926556001108 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 926556001109 Methyltransferase domain; Region: Methyltransf_26; pfam13659 926556001110 Virulence protein [General function prediction only]; Region: COG3943 926556001111 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 926556001112 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 926556001113 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 926556001114 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926556001115 ATP binding site [chemical binding]; other site 926556001116 putative Mg++ binding site [ion binding]; other site 926556001117 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556001118 non-specific DNA binding site [nucleotide binding]; other site 926556001119 salt bridge; other site 926556001120 sequence-specific DNA binding site [nucleotide binding]; other site 926556001121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556001122 non-specific DNA binding site [nucleotide binding]; other site 926556001123 salt bridge; other site 926556001124 sequence-specific DNA binding site [nucleotide binding]; other site 926556001125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556001126 non-specific DNA binding site [nucleotide binding]; other site 926556001127 salt bridge; other site 926556001128 sequence-specific DNA binding site [nucleotide binding]; other site 926556001129 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 926556001130 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 926556001131 Helix-turn-helix domain; Region: HTH_17; pfam12728 926556001132 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 926556001133 MPN+ (JAMM) motif; other site 926556001134 Zinc-binding site [ion binding]; other site 926556001135 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 926556001136 DNA-binding site [nucleotide binding]; DNA binding site 926556001137 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 926556001138 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926556001139 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 926556001140 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 926556001141 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 926556001142 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 926556001143 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 926556001144 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 926556001145 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 926556001146 active site 926556001147 catalytic triad [active] 926556001148 oxyanion hole [active] 926556001149 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556001150 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556001151 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556001152 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556001153 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556001154 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556001155 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556001156 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 926556001157 active site 926556001158 catalytic triad [active] 926556001159 oxyanion hole [active] 926556001160 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 926556001161 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926556001162 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 926556001163 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 926556001164 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 926556001165 hexamer (dimer of trimers) interface [polypeptide binding]; other site 926556001166 trimer interface [polypeptide binding]; other site 926556001167 substrate binding site [chemical binding]; other site 926556001168 Mn binding site [ion binding]; other site 926556001169 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556001170 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556001171 SusD family; Region: SusD; pfam07980 926556001172 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556001173 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556001174 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556001175 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556001176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556001177 D-galactonate transporter; Region: 2A0114; TIGR00893 926556001178 putative substrate translocation pore; other site 926556001179 transcriptional regulator protein; Region: phnR; TIGR03337 926556001180 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 926556001181 DNA-binding site [nucleotide binding]; DNA binding site 926556001182 UTRA domain; Region: UTRA; pfam07702 926556001183 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 926556001184 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926556001185 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 926556001186 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 926556001187 Fic/DOC family; Region: Fic; cl00960 926556001188 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926556001189 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 926556001190 active site 926556001191 DNA binding site [nucleotide binding] 926556001192 Int/Topo IB signature motif; other site 926556001193 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 926556001194 Transposase; Region: DDE_Tnp_ISL3; pfam01610 926556001195 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 926556001196 active site 926556001197 Zn binding site [ion binding]; other site 926556001198 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 926556001199 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 926556001200 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 926556001201 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 926556001202 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926556001203 ATP binding site [chemical binding]; other site 926556001204 putative Mg++ binding site [ion binding]; other site 926556001205 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 926556001206 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 926556001207 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 926556001208 HsdM N-terminal domain; Region: HsdM_N; pfam12161 926556001209 Methyltransferase domain; Region: Methyltransf_26; pfam13659 926556001210 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556001211 non-specific DNA binding site [nucleotide binding]; other site 926556001212 salt bridge; other site 926556001213 sequence-specific DNA binding site [nucleotide binding]; other site 926556001214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556001215 non-specific DNA binding site [nucleotide binding]; other site 926556001216 salt bridge; other site 926556001217 sequence-specific DNA binding site [nucleotide binding]; other site 926556001218 Homeodomain-like domain; Region: HTH_23; cl17451 926556001219 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 926556001220 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 926556001221 CHC2 zinc finger; Region: zf-CHC2; cl17510 926556001222 Toprim-like; Region: Toprim_2; pfam13155 926556001223 Helix-turn-helix domain; Region: HTH_17; pfam12728 926556001224 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 926556001225 MPN+ (JAMM) motif; other site 926556001226 Zinc-binding site [ion binding]; other site 926556001227 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 926556001228 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 926556001229 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 926556001230 active site 926556001231 metal binding site [ion binding]; metal-binding site 926556001232 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 926556001233 Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; cl17890 926556001234 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 926556001235 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926556001236 ATP binding site [chemical binding]; other site 926556001237 putative Mg++ binding site [ion binding]; other site 926556001238 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926556001239 nucleotide binding region [chemical binding]; other site 926556001240 ATP-binding site [chemical binding]; other site 926556001241 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 926556001242 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926556001243 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556001244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 926556001245 binding surface 926556001246 TPR motif; other site 926556001247 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 926556001248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556001249 binding surface 926556001250 TPR motif; other site 926556001251 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926556001252 CHAT domain; Region: CHAT; pfam12770 926556001253 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 926556001254 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 926556001255 Fic/DOC family; Region: Fic; cl00960 926556001256 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 926556001257 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 926556001258 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 926556001259 active site 926556001260 Zn binding site [ion binding]; other site 926556001261 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926556001262 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 926556001263 AAA domain; Region: AAA_21; pfam13304 926556001264 RloB-like protein; Region: RloB; pfam13707 926556001265 SusD family; Region: SusD; pfam07980 926556001266 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556001267 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556001268 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556001269 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556001270 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 926556001271 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 926556001272 dimer interface [polypeptide binding]; other site 926556001273 active site 926556001274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926556001275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926556001276 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926556001277 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926556001278 active site 926556001279 catalytic tetrad [active] 926556001280 YciI-like protein; Reviewed; Region: PRK12866 926556001281 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 926556001282 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 926556001283 active site 926556001284 metal binding site [ion binding]; metal-binding site 926556001285 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 926556001286 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 926556001287 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 926556001288 ATP-binding site [chemical binding]; other site 926556001289 Gluconate-6-phosphate binding site [chemical binding]; other site 926556001290 Shikimate kinase; Region: SKI; pfam01202 926556001291 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 926556001292 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 926556001293 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 926556001294 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556001295 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556001296 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 926556001297 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 926556001298 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556001299 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556001300 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 926556001301 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 926556001302 NAD(P) binding site [chemical binding]; other site 926556001303 catalytic residues [active] 926556001304 Protein of unknown function (DUF779); Region: DUF779; pfam05610 926556001305 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 926556001306 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556001307 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 926556001308 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 926556001309 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 926556001310 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 926556001311 active site 926556001312 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 926556001313 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 926556001314 active site 926556001315 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 926556001316 BNR repeat-like domain; Region: BNR_2; pfam13088 926556001317 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 926556001318 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 926556001319 active site 926556001320 catalytic residues [active] 926556001321 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 926556001322 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556001323 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556001324 SusD family; Region: SusD; pfam07980 926556001325 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556001326 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556001327 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556001328 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556001329 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 926556001330 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 926556001331 active site 926556001332 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 926556001333 substrate binding site [chemical binding]; other site 926556001334 active site 926556001335 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 926556001336 active site 926556001337 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 926556001338 active site 926556001339 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 926556001340 active site 926556001341 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 926556001342 substrate binding site [chemical binding]; other site 926556001343 active site 926556001344 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_37; cd04696 926556001345 nudix motif; other site 926556001346 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 926556001347 active site 926556001348 catalytic residues [active] 926556001349 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 926556001350 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 926556001351 intersubunit interface [polypeptide binding]; other site 926556001352 active site 926556001353 Zn2+ binding site [ion binding]; other site 926556001354 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 926556001355 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 926556001356 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 926556001357 Histidine kinase; Region: HisKA_2; pfam07568 926556001358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556001359 ATP binding site [chemical binding]; other site 926556001360 Mg2+ binding site [ion binding]; other site 926556001361 G-X-G motif; other site 926556001362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556001363 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926556001364 active site 926556001365 phosphorylation site [posttranslational modification] 926556001366 intermolecular recognition site; other site 926556001367 dimerization interface [polypeptide binding]; other site 926556001368 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926556001369 DNA binding residues [nucleotide binding] 926556001370 dimerization interface [polypeptide binding]; other site 926556001371 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 926556001372 BNR repeat-like domain; Region: BNR_2; pfam13088 926556001373 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 926556001374 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 926556001375 putative NAD(P) binding site [chemical binding]; other site 926556001376 catalytic Zn binding site [ion binding]; other site 926556001377 structural Zn binding site [ion binding]; other site 926556001378 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 926556001379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556001380 putative substrate translocation pore; other site 926556001381 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926556001382 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926556001383 active site 926556001384 catalytic tetrad [active] 926556001385 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926556001386 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926556001387 DNA binding site [nucleotide binding] 926556001388 domain linker motif; other site 926556001389 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 926556001390 dimerization interface [polypeptide binding]; other site 926556001391 ligand binding site [chemical binding]; other site 926556001392 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 926556001393 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 926556001394 ATP binding site [chemical binding]; other site 926556001395 Mg++ binding site [ion binding]; other site 926556001396 motif III; other site 926556001397 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926556001398 nucleotide binding region [chemical binding]; other site 926556001399 ATP-binding site [chemical binding]; other site 926556001400 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 926556001401 Mechanosensitive ion channel; Region: MS_channel; pfam00924 926556001402 VIT family; Region: VIT1; pfam01988 926556001403 ribulokinase; Provisional; Region: PRK04123 926556001404 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 926556001405 N- and C-terminal domain interface [polypeptide binding]; other site 926556001406 active site 926556001407 MgATP binding site [chemical binding]; other site 926556001408 catalytic site [active] 926556001409 metal binding site [ion binding]; metal-binding site 926556001410 carbohydrate binding site [chemical binding]; other site 926556001411 homodimer interface [polypeptide binding]; other site 926556001412 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 926556001413 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 926556001414 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 926556001415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 926556001416 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 926556001417 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 926556001418 substrate binding site [chemical binding]; other site 926556001419 active site 926556001420 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 926556001421 substrate binding site [chemical binding]; other site 926556001422 active site 926556001423 Protein of unknown function (DUF3823); Region: DUF3823; pfam12866 926556001424 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556001425 SusD family; Region: SusD; pfam07980 926556001426 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556001427 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556001428 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556001429 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 926556001430 Zn binding site [ion binding]; other site 926556001431 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 926556001432 GIY-YIG motif/motif A; other site 926556001433 putative active site [active] 926556001434 putative metal binding site [ion binding]; other site 926556001435 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 926556001436 GIY-YIG motif/motif A; other site 926556001437 putative active site [active] 926556001438 putative metal binding site [ion binding]; other site 926556001439 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 926556001440 GIY-YIG motif/motif A; other site 926556001441 putative active site [active] 926556001442 putative metal binding site [ion binding]; other site 926556001443 aldehyde dehydrogenase family 7 member; Region: PLN02315 926556001444 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 926556001445 tetrameric interface [polypeptide binding]; other site 926556001446 NAD binding site [chemical binding]; other site 926556001447 catalytic residues [active] 926556001448 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 926556001449 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 926556001450 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 926556001451 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926556001452 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 926556001453 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556001454 Galactose oxidase, central domain; Region: Kelch_3; cl02701 926556001455 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 926556001456 Protein of unknown function (DUF3823); Region: DUF3823; pfam12866 926556001457 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556001458 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556001459 SusD family; Region: SusD; pfam07980 926556001460 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556001461 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556001462 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556001463 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556001464 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556001465 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 926556001466 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926556001467 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 926556001468 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 926556001469 Mechanosensitive ion channel; Region: MS_channel; pfam00924 926556001470 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 926556001471 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 926556001472 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 926556001473 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 926556001474 putative dimer interface [polypeptide binding]; other site 926556001475 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 926556001476 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 926556001477 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 926556001478 protein binding site [polypeptide binding]; other site 926556001479 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 926556001480 protein binding site [polypeptide binding]; other site 926556001481 FkbH-like domain; Region: FkbH; TIGR01686 926556001482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926556001483 active site 926556001484 motif I; other site 926556001485 motif II; other site 926556001486 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926556001487 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926556001488 DNA binding residues [nucleotide binding] 926556001489 dimerization interface [polypeptide binding]; other site 926556001490 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 926556001491 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 926556001492 substrate binding site [chemical binding]; other site 926556001493 ATP binding site [chemical binding]; other site 926556001494 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 926556001495 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 926556001496 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926556001497 FeS/SAM binding site; other site 926556001498 TRAM domain; Region: TRAM; cl01282 926556001499 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556001500 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556001501 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556001502 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556001503 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556001504 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556001505 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556001506 SusD family; Region: SusD; pfam07980 926556001507 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 926556001508 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 926556001509 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 926556001510 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 926556001511 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 926556001512 ribosomal protein L33; Region: rpl33; CHL00104 926556001513 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 926556001514 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 926556001515 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 926556001516 inhibitor-cofactor binding pocket; inhibition site 926556001517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556001518 catalytic residue [active] 926556001519 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 926556001520 dimer interface [polypeptide binding]; other site 926556001521 allosteric magnesium binding site [ion binding]; other site 926556001522 active site 926556001523 aspartate-rich active site metal binding site; other site 926556001524 Schiff base residues; other site 926556001525 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 926556001526 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 926556001527 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 926556001528 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 926556001529 active site 926556001530 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 926556001531 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 926556001532 G1 box; other site 926556001533 putative GEF interaction site [polypeptide binding]; other site 926556001534 GTP/Mg2+ binding site [chemical binding]; other site 926556001535 Switch I region; other site 926556001536 G2 box; other site 926556001537 G3 box; other site 926556001538 Switch II region; other site 926556001539 G4 box; other site 926556001540 G5 box; other site 926556001541 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 926556001542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556001543 ATP binding site [chemical binding]; other site 926556001544 Mg2+ binding site [ion binding]; other site 926556001545 G-X-G motif; other site 926556001546 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 926556001547 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 926556001548 dimerization interface [polypeptide binding]; other site 926556001549 DPS ferroxidase diiron center [ion binding]; other site 926556001550 ion pore; other site 926556001551 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 926556001552 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 926556001553 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 926556001554 Walker A/P-loop; other site 926556001555 ATP binding site [chemical binding]; other site 926556001556 Q-loop/lid; other site 926556001557 ABC transporter signature motif; other site 926556001558 Walker B; other site 926556001559 D-loop; other site 926556001560 H-loop/switch region; other site 926556001561 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 926556001562 chaperone protein DnaJ; Provisional; Region: PRK14289 926556001563 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 926556001564 HSP70 interaction site [polypeptide binding]; other site 926556001565 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 926556001566 substrate binding site [polypeptide binding]; other site 926556001567 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 926556001568 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 926556001569 dimer interface [polypeptide binding]; other site 926556001570 GrpE; Region: GrpE; pfam01025 926556001571 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 926556001572 dimer interface [polypeptide binding]; other site 926556001573 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 926556001574 GTPase CgtA; Reviewed; Region: obgE; PRK12299 926556001575 GTP1/OBG; Region: GTP1_OBG; pfam01018 926556001576 Obg GTPase; Region: Obg; cd01898 926556001577 G1 box; other site 926556001578 GTP/Mg2+ binding site [chemical binding]; other site 926556001579 Switch I region; other site 926556001580 G2 box; other site 926556001581 G3 box; other site 926556001582 Switch II region; other site 926556001583 G4 box; other site 926556001584 G5 box; other site 926556001585 adenylate kinase; Reviewed; Region: adk; PRK00279 926556001586 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 926556001587 AMP-binding site [chemical binding]; other site 926556001588 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 926556001589 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926556001590 active site 926556001591 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 926556001592 M42 glutamyl aminopeptidase; Region: Peptidase_M42; cl17262 926556001593 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 926556001594 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926556001595 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926556001596 ligand binding site [chemical binding]; other site 926556001597 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926556001598 active site 926556001599 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 926556001600 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 926556001601 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 926556001602 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 926556001603 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 926556001604 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 926556001605 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926556001606 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 926556001607 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556001608 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556001609 DNA binding residues [nucleotide binding] 926556001610 OsmC-like protein; Region: OsmC; pfam02566 926556001611 lipoyl synthase; Provisional; Region: PRK05481 926556001612 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926556001613 FeS/SAM binding site; other site 926556001614 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 926556001615 core domain interface [polypeptide binding]; other site 926556001616 delta subunit interface [polypeptide binding]; other site 926556001617 epsilon subunit interface [polypeptide binding]; other site 926556001618 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 926556001619 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 926556001620 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 926556001621 beta subunit interaction interface [polypeptide binding]; other site 926556001622 Walker A motif; other site 926556001623 ATP binding site [chemical binding]; other site 926556001624 Walker B motif; other site 926556001625 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 926556001626 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 926556001627 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 926556001628 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 926556001629 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 926556001630 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 926556001631 ATP synthase A chain; Region: ATP-synt_A; cl00413 926556001632 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 926556001633 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 926556001634 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 926556001635 Peptidase family M23; Region: Peptidase_M23; pfam01551 926556001636 Transglycosylase; Region: Transgly; pfam00912 926556001637 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 926556001638 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 926556001639 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 926556001640 GIY-YIG motif/motif A; other site 926556001641 active site 926556001642 catalytic site [active] 926556001643 putative DNA binding site [nucleotide binding]; other site 926556001644 metal binding site [ion binding]; metal-binding site 926556001645 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 926556001646 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 926556001647 DNA binding site [nucleotide binding] 926556001648 gliding motility associated protien GldN; Region: GldN; TIGR03523 926556001649 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 926556001650 GldM N-terminal domain; Region: GldM_N; pfam12081 926556001651 GldM C-terminal domain; Region: GldM_C; pfam12080 926556001652 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 926556001653 gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529 926556001654 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 926556001655 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 926556001656 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 926556001657 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 926556001658 active site 926556001659 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 926556001660 Surface antigen; Region: Bac_surface_Ag; pfam01103 926556001661 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 926556001662 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926556001663 FeS/SAM binding site; other site 926556001664 HemN C-terminal domain; Region: HemN_C; pfam06969 926556001665 Protein of unknown function (DUF721); Region: DUF721; pfam05258 926556001666 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 926556001667 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 926556001668 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 926556001669 dimer interface [polypeptide binding]; other site 926556001670 motif 1; other site 926556001671 active site 926556001672 motif 2; other site 926556001673 motif 3; other site 926556001674 SurA N-terminal domain; Region: SurA_N; pfam09312 926556001675 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 926556001676 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 926556001677 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 926556001678 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 926556001679 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 926556001680 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 926556001681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556001682 ATP binding site [chemical binding]; other site 926556001683 Mg2+ binding site [ion binding]; other site 926556001684 G-X-G motif; other site 926556001685 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 926556001686 anti sigma factor interaction site; other site 926556001687 regulatory phosphorylation site [posttranslational modification]; other site 926556001688 GAF domain; Region: GAF_2; pfam13185 926556001689 GAF domain; Region: GAF_3; pfam13492 926556001690 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 926556001691 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 926556001692 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 926556001693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 926556001694 Transposase; Region: DEDD_Tnp_IS110; pfam01548 926556001695 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 926556001696 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 926556001697 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 926556001698 RNA binding surface [nucleotide binding]; other site 926556001699 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 926556001700 active site 926556001701 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 926556001702 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 926556001703 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926556001704 catalytic residue [active] 926556001705 hypothetical protein; Provisional; Region: PRK04164 926556001706 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 926556001707 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 926556001708 ferrochelatase; Reviewed; Region: hemH; PRK00035 926556001709 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 926556001710 C-terminal domain interface [polypeptide binding]; other site 926556001711 active site 926556001712 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 926556001713 active site 926556001714 N-terminal domain interface [polypeptide binding]; other site 926556001715 Transposase; Region: DEDD_Tnp_IS110; pfam01548 926556001716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 926556001717 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 926556001718 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 926556001719 catalytic residues [active] 926556001720 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 926556001721 periplasmic chaperone; Provisional; Region: PRK10780 926556001722 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 926556001723 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 926556001724 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 926556001725 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 926556001726 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 926556001727 Surface antigen; Region: Bac_surface_Ag; pfam01103 926556001728 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 926556001729 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 926556001730 catalytic residue [active] 926556001731 putative FPP diphosphate binding site; other site 926556001732 putative FPP binding hydrophobic cleft; other site 926556001733 dimer interface [polypeptide binding]; other site 926556001734 putative IPP diphosphate binding site; other site 926556001735 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926556001736 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 926556001737 ATP-NAD kinase; Region: NAD_kinase; pfam01513 926556001738 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 926556001739 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 926556001740 Glutamine amidotransferase class-I; Region: GATase; pfam00117 926556001741 glutamine binding [chemical binding]; other site 926556001742 catalytic triad [active] 926556001743 Colicin V production protein; Region: Colicin_V; pfam02674 926556001744 Yqey-like protein; Region: YqeY; pfam09424 926556001745 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 926556001746 active site 926556001747 hydrophilic channel; other site 926556001748 dimerization interface [polypeptide binding]; other site 926556001749 catalytic residues [active] 926556001750 active site lid [active] 926556001751 acyl-CoA esterase; Provisional; Region: PRK10673 926556001752 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 926556001753 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 926556001754 putative SAM binding site [chemical binding]; other site 926556001755 homodimer interface [polypeptide binding]; other site 926556001756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556001757 S-adenosylmethionine binding site [chemical binding]; other site 926556001758 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 926556001759 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926556001760 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 926556001761 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 926556001762 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 926556001763 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 926556001764 substrate binding pocket [chemical binding]; other site 926556001765 chain length determination region; other site 926556001766 substrate-Mg2+ binding site; other site 926556001767 catalytic residues [active] 926556001768 aspartate-rich region 1; other site 926556001769 active site lid residues [active] 926556001770 aspartate-rich region 2; other site 926556001771 ribonuclease R; Region: RNase_R; TIGR02063 926556001772 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 926556001773 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 926556001774 RNB domain; Region: RNB; pfam00773 926556001775 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 926556001776 RNA binding site [nucleotide binding]; other site 926556001777 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 926556001778 active site 926556001779 catalytic site [active] 926556001780 substrate binding site [chemical binding]; other site 926556001781 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 926556001782 hypothetical protein; Reviewed; Region: PRK12497 926556001783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 926556001784 aspartate aminotransferase; Provisional; Region: PRK05764 926556001785 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926556001786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556001787 homodimer interface [polypeptide binding]; other site 926556001788 catalytic residue [active] 926556001789 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926556001790 active site 926556001791 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926556001792 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926556001793 active site 926556001794 Domain of unknown function (DUF4421); Region: DUF4421; pfam14391 926556001795 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926556001796 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926556001797 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556001798 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 926556001799 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 926556001800 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926556001801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556001802 binding surface 926556001803 TPR motif; other site 926556001804 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926556001805 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926556001806 Histidine kinase; Region: His_kinase; pfam06580 926556001807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556001808 ATP binding site [chemical binding]; other site 926556001809 Mg2+ binding site [ion binding]; other site 926556001810 G-X-G motif; other site 926556001811 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 926556001812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556001813 active site 926556001814 phosphorylation site [posttranslational modification] 926556001815 intermolecular recognition site; other site 926556001816 dimerization interface [polypeptide binding]; other site 926556001817 LytTr DNA-binding domain; Region: LytTR; smart00850 926556001818 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 926556001819 substrate binding pocket [chemical binding]; other site 926556001820 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 926556001821 membrane-bound complex binding site; other site 926556001822 hinge residues; other site 926556001823 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 926556001824 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 926556001825 N-acetyl-D-glucosamine binding site [chemical binding]; other site 926556001826 catalytic residue [active] 926556001827 glycyl-tRNA synthetase; Provisional; Region: PRK04173 926556001828 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 926556001829 motif 1; other site 926556001830 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 926556001831 active site 926556001832 motif 2; other site 926556001833 motif 3; other site 926556001834 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 926556001835 anticodon binding site; other site 926556001836 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 926556001837 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926556001838 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926556001839 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 926556001840 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 926556001841 ATP-grasp domain; Region: ATP-grasp_4; cl17255 926556001842 S-adenosylmethionine synthetase; Validated; Region: PRK05250 926556001843 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 926556001844 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 926556001845 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 926556001846 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 926556001847 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 926556001848 dimer interface [polypeptide binding]; other site 926556001849 active site 926556001850 galactokinase; Provisional; Region: PRK05322 926556001851 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 926556001852 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 926556001853 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 926556001854 active site 926556001855 catalytic residues [active] 926556001856 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926556001857 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926556001858 DNA binding site [nucleotide binding] 926556001859 domain linker motif; other site 926556001860 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 926556001861 dimerization interface [polypeptide binding]; other site 926556001862 ligand binding site [chemical binding]; other site 926556001863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 926556001864 Transposase; Region: DEDD_Tnp_IS110; pfam01548 926556001865 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 926556001866 M28 Zn-Peptidases; Region: M28_like_6; cd08656 926556001867 Peptidase family M28; Region: Peptidase_M28; pfam04389 926556001868 metal binding site [ion binding]; metal-binding site 926556001869 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 926556001870 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 926556001871 active site 926556001872 HIGH motif; other site 926556001873 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 926556001874 KMSKS motif; other site 926556001875 DALR domain; Region: DALR_2; pfam09190 926556001876 ribosome maturation protein RimP; Reviewed; Region: PRK00092 926556001877 Sm and related proteins; Region: Sm_like; cl00259 926556001878 heptamer interface [polypeptide binding]; other site 926556001879 Sm1 motif; other site 926556001880 hexamer interface [polypeptide binding]; other site 926556001881 RNA binding site [nucleotide binding]; other site 926556001882 Sm2 motif; other site 926556001883 transcription termination factor NusA; Region: NusA; TIGR01953 926556001884 NusA N-terminal domain; Region: NusA_N; pfam08529 926556001885 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 926556001886 RNA binding site [nucleotide binding]; other site 926556001887 homodimer interface [polypeptide binding]; other site 926556001888 NusA-like KH domain; Region: KH_5; pfam13184 926556001889 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 926556001890 G-X-X-G motif; other site 926556001891 translation initiation factor IF-2; Region: IF-2; TIGR00487 926556001892 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 926556001893 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 926556001894 G1 box; other site 926556001895 putative GEF interaction site [polypeptide binding]; other site 926556001896 GTP/Mg2+ binding site [chemical binding]; other site 926556001897 Switch I region; other site 926556001898 G2 box; other site 926556001899 G3 box; other site 926556001900 Switch II region; other site 926556001901 G4 box; other site 926556001902 G5 box; other site 926556001903 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 926556001904 Translation-initiation factor 2; Region: IF-2; pfam11987 926556001905 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 926556001906 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 926556001907 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 926556001908 Lamin Tail Domain; Region: LTD; pfam00932 926556001909 Lamin Tail Domain; Region: LTD; pfam00932 926556001910 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 926556001911 catalytic nucleophile [active] 926556001912 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 926556001913 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 926556001914 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 926556001915 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 926556001916 RNA binding surface [nucleotide binding]; other site 926556001917 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 926556001918 active site 926556001919 Domain of unknown function (DUF427); Region: DUF427; pfam04248 926556001920 mercuric reductase; Validated; Region: PRK06370 926556001921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926556001922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926556001923 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 926556001924 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 926556001925 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 926556001926 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926556001927 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556001928 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556001929 DNA binding residues [nucleotide binding] 926556001930 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 926556001931 4Fe-4S binding domain; Region: Fer4; cl02805 926556001932 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 926556001933 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 926556001934 Cysteine-rich domain; Region: CCG; pfam02754 926556001935 Cysteine-rich domain; Region: CCG; pfam02754 926556001936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556001937 binding surface 926556001938 Tetratricopeptide repeat; Region: TPR_16; pfam13432 926556001939 TPR motif; other site 926556001940 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926556001941 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926556001942 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926556001943 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926556001944 ligand binding site [chemical binding]; other site 926556001945 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 926556001946 dimerization interface [polypeptide binding]; other site 926556001947 ATP binding site [chemical binding]; other site 926556001948 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 926556001949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556001950 S-adenosylmethionine binding site [chemical binding]; other site 926556001951 acyl-coenzyme A oxidase; Region: PLN02526 926556001952 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 926556001953 active site 926556001954 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 926556001955 active site 926556001956 catalytic triad [active] 926556001957 oxyanion hole [active] 926556001958 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 926556001959 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 926556001960 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926556001961 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 926556001962 ligand binding site [chemical binding]; other site 926556001963 flexible hinge region; other site 926556001964 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 926556001965 glycine dehydrogenase; Provisional; Region: PRK05367 926556001966 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 926556001967 tetramer interface [polypeptide binding]; other site 926556001968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556001969 catalytic residue [active] 926556001970 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 926556001971 tetramer interface [polypeptide binding]; other site 926556001972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556001973 catalytic residue [active] 926556001974 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 926556001975 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 926556001976 Peptidase family M28; Region: Peptidase_M28; pfam04389 926556001977 metal binding site [ion binding]; metal-binding site 926556001978 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 926556001979 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 926556001980 ATP binding site [chemical binding]; other site 926556001981 Mg++ binding site [ion binding]; other site 926556001982 motif III; other site 926556001983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926556001984 nucleotide binding region [chemical binding]; other site 926556001985 ATP-binding site [chemical binding]; other site 926556001986 dihydroorotase; Reviewed; Region: PRK09236 926556001987 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926556001988 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 926556001989 active site 926556001990 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 926556001991 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 926556001992 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 926556001993 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926556001994 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556001995 N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795 926556001996 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 926556001997 putative active site [active] 926556001998 catalytic site [active] 926556001999 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 926556002000 Clp amino terminal domain; Region: Clp_N; pfam02861 926556002001 Clp amino terminal domain; Region: Clp_N; pfam02861 926556002002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556002003 Walker A motif; other site 926556002004 ATP binding site [chemical binding]; other site 926556002005 Walker B motif; other site 926556002006 arginine finger; other site 926556002007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556002008 Walker A motif; other site 926556002009 ATP binding site [chemical binding]; other site 926556002010 Walker B motif; other site 926556002011 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 926556002012 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 926556002013 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926556002014 FeS/SAM binding site; other site 926556002015 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 926556002016 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 926556002017 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 926556002018 putative active site [active] 926556002019 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926556002020 nucleotide binding site [chemical binding]; other site 926556002021 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 926556002022 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 926556002023 putative active site [active] 926556002024 putative metal binding site [ion binding]; other site 926556002025 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 926556002026 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 926556002027 catalytic loop [active] 926556002028 iron binding site [ion binding]; other site 926556002029 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 926556002030 FAD binding pocket [chemical binding]; other site 926556002031 FAD binding motif [chemical binding]; other site 926556002032 phosphate binding motif [ion binding]; other site 926556002033 beta-alpha-beta structure motif; other site 926556002034 NAD binding pocket [chemical binding]; other site 926556002035 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 926556002036 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 926556002037 Mechanosensitive ion channel; Region: MS_channel; pfam00924 926556002038 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 926556002039 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 926556002040 Carbon starvation protein CstA; Region: CstA; pfam02554 926556002041 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 926556002042 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 926556002043 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 926556002044 ATP-grasp domain; Region: ATP-grasp_4; cl17255 926556002045 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 926556002046 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 926556002047 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 926556002048 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 926556002049 ATP-grasp domain; Region: ATP-grasp_4; cl17255 926556002050 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 926556002051 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 926556002052 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926556002053 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 926556002054 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 926556002055 four helix bundle protein; Region: TIGR02436 926556002056 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 926556002057 E3 interaction surface; other site 926556002058 lipoyl attachment site [posttranslational modification]; other site 926556002059 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 926556002060 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 926556002061 E3 interaction surface; other site 926556002062 lipoyl attachment site [posttranslational modification]; other site 926556002063 e3 binding domain; Region: E3_binding; pfam02817 926556002064 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 926556002065 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 926556002066 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 926556002067 TPP-binding site [chemical binding]; other site 926556002068 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 926556002069 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926556002070 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 926556002071 putative NAD(P) binding site [chemical binding]; other site 926556002072 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 926556002073 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 926556002074 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 926556002075 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 926556002076 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 926556002077 Beta-lactamase; Region: Beta-lactamase; cl17358 926556002078 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 926556002079 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 926556002080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556002081 ATP binding site [chemical binding]; other site 926556002082 Mg2+ binding site [ion binding]; other site 926556002083 G-X-G motif; other site 926556002084 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 926556002085 ATP binding site [chemical binding]; other site 926556002086 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 926556002087 Rhomboid family; Region: Rhomboid; pfam01694 926556002088 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 926556002089 Rhomboid family; Region: Rhomboid; pfam01694 926556002090 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 926556002091 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926556002092 ATP binding site [chemical binding]; other site 926556002093 putative Mg++ binding site [ion binding]; other site 926556002094 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926556002095 nucleotide binding region [chemical binding]; other site 926556002096 ATP-binding site [chemical binding]; other site 926556002097 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 926556002098 HRDC domain; Region: HRDC; pfam00570 926556002099 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 926556002100 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 926556002101 homodimer interface [polypeptide binding]; other site 926556002102 putative substrate binding pocket [chemical binding]; other site 926556002103 diiron center [ion binding]; other site 926556002104 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 926556002105 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556002106 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556002107 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556002108 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556002109 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556002110 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 926556002111 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556002112 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556002113 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556002114 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556002115 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556002116 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 926556002117 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 926556002118 active site 926556002119 dimer interface [polypeptide binding]; other site 926556002120 Peptidase family M1; Region: Peptidase_M1; pfam01433 926556002121 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 926556002122 Zn binding site [ion binding]; other site 926556002123 BCCT family transporter; Region: BCCT; pfam02028 926556002124 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926556002125 Ligand Binding Site [chemical binding]; other site 926556002126 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 926556002127 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 926556002128 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 926556002129 CcmE; Region: CcmE; cl00994 926556002130 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 926556002131 CcmB protein; Region: CcmB; cl17444 926556002132 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926556002133 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556002134 catalytic residues [active] 926556002135 seryl-tRNA synthetase; Provisional; Region: PRK05431 926556002136 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 926556002137 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 926556002138 dimer interface [polypeptide binding]; other site 926556002139 active site 926556002140 motif 1; other site 926556002141 motif 2; other site 926556002142 motif 3; other site 926556002143 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 926556002144 transcription termination factor Rho; Provisional; Region: PRK12608 926556002145 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 926556002146 RNA binding site [nucleotide binding]; other site 926556002147 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 926556002148 multimer interface [polypeptide binding]; other site 926556002149 Walker A motif; other site 926556002150 ATP binding site [chemical binding]; other site 926556002151 Walker B motif; other site 926556002152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 926556002153 Transposase; Region: DEDD_Tnp_IS110; pfam01548 926556002154 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 926556002155 Protein of unknown function (DUF342); Region: DUF342; pfam03961 926556002156 SprT homologues; Region: SprT; cl01182 926556002157 GTP-binding protein Der; Reviewed; Region: PRK00093 926556002158 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 926556002159 G1 box; other site 926556002160 GTP/Mg2+ binding site [chemical binding]; other site 926556002161 Switch I region; other site 926556002162 G2 box; other site 926556002163 Switch II region; other site 926556002164 G3 box; other site 926556002165 G4 box; other site 926556002166 G5 box; other site 926556002167 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 926556002168 G1 box; other site 926556002169 GTP/Mg2+ binding site [chemical binding]; other site 926556002170 Switch I region; other site 926556002171 G2 box; other site 926556002172 G3 box; other site 926556002173 Switch II region; other site 926556002174 G4 box; other site 926556002175 G5 box; other site 926556002176 GTPase Era; Reviewed; Region: era; PRK00089 926556002177 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 926556002178 G1 box; other site 926556002179 GTP/Mg2+ binding site [chemical binding]; other site 926556002180 Switch I region; other site 926556002181 G2 box; other site 926556002182 Switch II region; other site 926556002183 G3 box; other site 926556002184 G4 box; other site 926556002185 G5 box; other site 926556002186 Fic family protein [Function unknown]; Region: COG3177 926556002187 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 926556002188 Fic/DOC family; Region: Fic; pfam02661 926556002189 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 926556002190 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926556002191 ligand binding site [chemical binding]; other site 926556002192 flexible hinge region; other site 926556002193 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 926556002194 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 926556002195 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926556002196 Coenzyme A binding pocket [chemical binding]; other site 926556002197 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556002198 PAS domain; Region: PAS_9; pfam13426 926556002199 putative active site [active] 926556002200 heme pocket [chemical binding]; other site 926556002201 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556002202 PAS fold; Region: PAS_3; pfam08447 926556002203 putative active site [active] 926556002204 heme pocket [chemical binding]; other site 926556002205 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 926556002206 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 926556002207 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 926556002208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556002209 Walker A motif; other site 926556002210 ATP binding site [chemical binding]; other site 926556002211 Walker B motif; other site 926556002212 arginine finger; other site 926556002213 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 926556002214 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 926556002215 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926556002216 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 926556002217 active site 926556002218 DNA binding site [nucleotide binding] 926556002219 Int/Topo IB signature motif; other site 926556002220 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 926556002221 30S subunit binding site; other site 926556002222 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 926556002223 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 926556002224 active site 926556002225 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 926556002226 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 926556002227 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 926556002228 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 926556002229 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 926556002230 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926556002231 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 926556002232 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 926556002233 N-terminal plug; other site 926556002234 ligand-binding site [chemical binding]; other site 926556002235 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926556002236 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556002237 DNA binding residues [nucleotide binding] 926556002238 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926556002239 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556002240 YhhN-like protein; Region: YhhN; pfam07947 926556002241 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 926556002242 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 926556002243 dimer interface [polypeptide binding]; other site 926556002244 anticodon binding site; other site 926556002245 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 926556002246 homodimer interface [polypeptide binding]; other site 926556002247 motif 1; other site 926556002248 active site 926556002249 motif 2; other site 926556002250 GAD domain; Region: GAD; pfam02938 926556002251 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 926556002252 motif 3; other site 926556002253 putative peptidase; Provisional; Region: PRK11649 926556002254 Peptidase family M23; Region: Peptidase_M23; pfam01551 926556002255 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 926556002256 phosphoglyceromutase; Provisional; Region: PRK05434 926556002257 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 926556002258 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 926556002259 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 926556002260 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 926556002261 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 926556002262 active site 926556002263 dimerization interface [polypeptide binding]; other site 926556002264 Predicted methyltransferases [General function prediction only]; Region: COG0313 926556002265 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 926556002266 putative SAM binding site [chemical binding]; other site 926556002267 putative homodimer interface [polypeptide binding]; other site 926556002268 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 926556002269 aromatic arch; other site 926556002270 DCoH dimer interaction site [polypeptide binding]; other site 926556002271 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 926556002272 DCoH tetramer interaction site [polypeptide binding]; other site 926556002273 substrate binding site [chemical binding]; other site 926556002274 Protein of unknown function (DUF493); Region: DUF493; pfam04359 926556002275 SurA N-terminal domain; Region: SurA_N_3; cl07813 926556002276 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 926556002277 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 926556002278 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 926556002279 Domain of unknown function DUF21; Region: DUF21; pfam01595 926556002280 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 926556002281 Transporter associated domain; Region: CorC_HlyC; smart01091 926556002282 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 926556002283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556002284 TPR repeat; Region: TPR_11; pfam13414 926556002285 TPR motif; other site 926556002286 binding surface 926556002287 Type III pantothenate kinase; Region: Pan_kinase; cl17198 926556002288 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 926556002289 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 926556002290 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 926556002291 NAD(P) binding pocket [chemical binding]; other site 926556002292 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 926556002293 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 926556002294 transmembrane helices; other site 926556002295 RNA polymerase sigma factor; Provisional; Region: PRK12513 926556002296 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556002297 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556002298 DNA binding residues [nucleotide binding] 926556002299 Protein of unknown function (DUF541); Region: SIMPL; cl01077 926556002300 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 926556002301 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 926556002302 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 926556002303 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 926556002304 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 926556002305 Asp-box motif; other site 926556002306 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 926556002307 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 926556002308 catalytic residues [active] 926556002309 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 926556002310 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 926556002311 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926556002312 catalytic residue [active] 926556002313 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 926556002314 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 926556002315 active site 926556002316 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 926556002317 putative active site [active] 926556002318 Zn binding site [ion binding]; other site 926556002319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 926556002320 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 926556002321 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 926556002322 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 926556002323 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 926556002324 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 926556002325 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 926556002326 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 926556002327 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 926556002328 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556002329 Sulfatase; Region: Sulfatase; pfam00884 926556002330 Surface antigen; Region: Bac_surface_Ag; pfam01103 926556002331 MutS domain III; Region: MutS_III; pfam05192 926556002332 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 926556002333 Walker A/P-loop; other site 926556002334 ATP binding site [chemical binding]; other site 926556002335 Q-loop/lid; other site 926556002336 ABC transporter signature motif; other site 926556002337 Walker B; other site 926556002338 D-loop; other site 926556002339 H-loop/switch region; other site 926556002340 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 926556002341 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 926556002342 NAD binding site [chemical binding]; other site 926556002343 ATP-grasp domain; Region: ATP-grasp; pfam02222 926556002344 AIR carboxylase; Region: AIRC; pfam00731 926556002345 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926556002346 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926556002347 DNA binding residues [nucleotide binding] 926556002348 dimerization interface [polypeptide binding]; other site 926556002349 Protein of unknown function, DUF399; Region: DUF399; pfam04187 926556002350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556002351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556002352 dimer interface [polypeptide binding]; other site 926556002353 phosphorylation site [posttranslational modification] 926556002354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556002355 ATP binding site [chemical binding]; other site 926556002356 Mg2+ binding site [ion binding]; other site 926556002357 G-X-G motif; other site 926556002358 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 926556002359 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556002360 putative catalytic residues [active] 926556002361 Predicted transcriptional regulators [Transcription]; Region: COG1733 926556002362 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 926556002363 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 926556002364 dimer interface [polypeptide binding]; other site 926556002365 FMN binding site [chemical binding]; other site 926556002366 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 926556002367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556002368 S-adenosylmethionine binding site [chemical binding]; other site 926556002369 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 926556002370 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556002371 Sulfatase; Region: Sulfatase; pfam00884 926556002372 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 926556002373 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 926556002374 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 926556002375 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 926556002376 Ligand binding site; other site 926556002377 Putative Catalytic site; other site 926556002378 DXD motif; other site 926556002379 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 926556002380 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 926556002381 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 926556002382 G1 box; other site 926556002383 GTP/Mg2+ binding site [chemical binding]; other site 926556002384 Switch I region; other site 926556002385 G2 box; other site 926556002386 G3 box; other site 926556002387 Switch II region; other site 926556002388 G4 box; other site 926556002389 G5 box; other site 926556002390 Nucleoside recognition; Region: Gate; pfam07670 926556002391 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 926556002392 Nucleoside recognition; Region: Gate; pfam07670 926556002393 FeoA domain; Region: FeoA; pfam04023 926556002394 Glycosyl hydrolase family 43; Region: GH43_3; cd08982 926556002395 active site 926556002396 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 926556002397 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926556002398 Interdomain contacts; other site 926556002399 Cytokine receptor motif; other site 926556002400 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 926556002401 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 926556002402 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926556002403 active site 926556002404 HIGH motif; other site 926556002405 nucleotide binding site [chemical binding]; other site 926556002406 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 926556002407 active site 926556002408 KMSKS motif; other site 926556002409 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 926556002410 tRNA binding surface [nucleotide binding]; other site 926556002411 anticodon binding site; other site 926556002412 lipoprotein signal peptidase; Provisional; Region: PRK14788 926556002413 lipoprotein signal peptidase; Provisional; Region: PRK14787 926556002414 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 926556002415 Transposase; Region: DEDD_Tnp_IS110; pfam01548 926556002416 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 926556002417 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 926556002418 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 926556002419 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 926556002420 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 926556002421 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 926556002422 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 926556002423 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 926556002424 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 926556002425 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 926556002426 active site 926556002427 NAD binding site [chemical binding]; other site 926556002428 metal binding site [ion binding]; metal-binding site 926556002429 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 926556002430 Na binding site [ion binding]; other site 926556002431 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 926556002432 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 926556002433 inhibitor site; inhibition site 926556002434 active site 926556002435 dimer interface [polypeptide binding]; other site 926556002436 catalytic residue [active] 926556002437 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 926556002438 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 926556002439 BNR repeat-like domain; Region: BNR_2; pfam13088 926556002440 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 926556002441 active site 926556002442 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 926556002443 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 926556002444 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 926556002445 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 926556002446 Protein of unknown function (DUF3826); Region: DUF3826; pfam12875 926556002447 Pectate lyase; Region: Pec_lyase_C; cl01593 926556002448 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 926556002449 Sulfatase; Region: Sulfatase; cl17466 926556002450 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556002451 DinB superfamily; Region: DinB_2; pfam12867 926556002452 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 926556002453 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 926556002454 active site 926556002455 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 926556002456 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556002457 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926556002458 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 926556002459 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 926556002460 trimer interface [polypeptide binding]; other site 926556002461 active site 926556002462 substrate binding site [chemical binding]; other site 926556002463 CoA binding site [chemical binding]; other site 926556002464 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 926556002465 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556002466 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 926556002467 O-Antigen ligase; Region: Wzy_C; cl04850 926556002468 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926556002469 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 926556002470 Probable Catalytic site; other site 926556002471 metal-binding site 926556002472 Methyltransferase domain; Region: Methyltransf_23; pfam13489 926556002473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556002474 S-adenosylmethionine binding site [chemical binding]; other site 926556002475 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 926556002476 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 926556002477 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 926556002478 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 926556002479 SLBB domain; Region: SLBB; pfam10531 926556002480 SLBB domain; Region: SLBB; pfam10531 926556002481 SLBB domain; Region: SLBB; pfam10531 926556002482 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556002483 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556002484 SusD family; Region: SusD; pfam07980 926556002485 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556002486 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556002487 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556002488 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556002489 Radical SAM superfamily; Region: Radical_SAM; pfam04055 926556002490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926556002491 FeS/SAM binding site; other site 926556002492 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 926556002493 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 926556002494 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 926556002495 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 926556002496 MutS domain I; Region: MutS_I; pfam01624 926556002497 MutS domain II; Region: MutS_II; pfam05188 926556002498 MutS domain III; Region: MutS_III; pfam05192 926556002499 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 926556002500 Walker A/P-loop; other site 926556002501 ATP binding site [chemical binding]; other site 926556002502 Q-loop/lid; other site 926556002503 ABC transporter signature motif; other site 926556002504 Walker B; other site 926556002505 D-loop; other site 926556002506 H-loop/switch region; other site 926556002507 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 926556002508 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 926556002509 catalytic motif [active] 926556002510 Zn binding site [ion binding]; other site 926556002511 RibD C-terminal domain; Region: RibD_C; cl17279 926556002512 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 926556002513 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 926556002514 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 926556002515 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 926556002516 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926556002517 Zn2+ binding site [ion binding]; other site 926556002518 Mg2+ binding site [ion binding]; other site 926556002519 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 926556002520 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 926556002521 putative ligand binding site [chemical binding]; other site 926556002522 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 926556002523 Protein of unknown function (DUF805); Region: DUF805; pfam05656 926556002524 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 926556002525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556002526 S-adenosylmethionine binding site [chemical binding]; other site 926556002527 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_12; cd13142 926556002528 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 926556002529 Phosphoesterase family; Region: Phosphoesterase; pfam04185 926556002530 Phosphoesterase family; Region: Phosphoesterase; pfam04185 926556002531 Domain of unknown function (DUF756); Region: DUF756; pfam05506 926556002532 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 926556002533 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556002534 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556002535 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556002536 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556002537 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556002538 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 926556002539 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 926556002540 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 926556002541 active site 926556002542 SAM binding site [chemical binding]; other site 926556002543 homodimer interface [polypeptide binding]; other site 926556002544 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 926556002545 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 926556002546 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 926556002547 HEPN domain; Region: HEPN; cl00824 926556002548 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 926556002549 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 926556002550 CysD dimerization site [polypeptide binding]; other site 926556002551 G1 box; other site 926556002552 putative GEF interaction site [polypeptide binding]; other site 926556002553 GTP/Mg2+ binding site [chemical binding]; other site 926556002554 Switch I region; other site 926556002555 G2 box; other site 926556002556 G3 box; other site 926556002557 Switch II region; other site 926556002558 G4 box; other site 926556002559 G5 box; other site 926556002560 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 926556002561 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 926556002562 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 926556002563 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 926556002564 Active Sites [active] 926556002565 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 926556002566 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 926556002567 Active Sites [active] 926556002568 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 926556002569 Rrf2 family protein; Region: rrf2_super; TIGR00738 926556002570 Transcriptional regulator; Region: Rrf2; pfam02082 926556002571 heat shock protein 90; Provisional; Region: PRK05218 926556002572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556002573 ATP binding site [chemical binding]; other site 926556002574 Mg2+ binding site [ion binding]; other site 926556002575 G-X-G motif; other site 926556002576 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 926556002577 putative active site [active] 926556002578 putative cosubstrate binding site; other site 926556002579 putative substrate binding site [chemical binding]; other site 926556002580 catalytic site [active] 926556002581 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 926556002582 putative uracil binding site [chemical binding]; other site 926556002583 putative active site [active] 926556002584 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 926556002585 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 926556002586 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 926556002587 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 926556002588 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 926556002589 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 926556002590 DHH family; Region: DHH; pfam01368 926556002591 DHHA1 domain; Region: DHHA1; pfam02272 926556002592 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 926556002593 active site 926556002594 multimer interface [polypeptide binding]; other site 926556002595 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 926556002596 ScpA/B protein; Region: ScpA_ScpB; cl00598 926556002597 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 926556002598 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 926556002599 TPP-binding site; other site 926556002600 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 926556002601 PYR/PP interface [polypeptide binding]; other site 926556002602 dimer interface [polypeptide binding]; other site 926556002603 TPP binding site [chemical binding]; other site 926556002604 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 926556002605 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926556002606 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926556002607 dimerization interface [polypeptide binding]; other site 926556002608 putative DNA binding site [nucleotide binding]; other site 926556002609 putative Zn2+ binding site [ion binding]; other site 926556002610 Low molecular weight phosphatase family; Region: LMWPc; cl00105 926556002611 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 926556002612 arsenical-resistance protein; Region: acr3; TIGR00832 926556002613 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556002614 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556002615 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 926556002616 Fatty acid desaturase; Region: FA_desaturase; pfam00487 926556002617 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 926556002618 putative di-iron ligands [ion binding]; other site 926556002619 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926556002620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 926556002621 binding surface 926556002622 TPR motif; other site 926556002623 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 926556002624 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 926556002625 RNA binding surface [nucleotide binding]; other site 926556002626 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 926556002627 probable active site [active] 926556002628 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 926556002629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 926556002630 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 926556002631 putative active site [active] 926556002632 Zn binding site [ion binding]; other site 926556002633 Transposase domain (DUF772); Region: DUF772; pfam05598 926556002634 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 926556002635 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 926556002636 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 926556002637 putative active site [active] 926556002638 putative NTP binding site [chemical binding]; other site 926556002639 putative nucleic acid binding site [nucleotide binding]; other site 926556002640 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 926556002641 Mechanosensitive ion channel; Region: MS_channel; pfam00924 926556002642 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 926556002643 metal binding site 2 [ion binding]; metal-binding site 926556002644 putative DNA binding helix; other site 926556002645 metal binding site 1 [ion binding]; metal-binding site 926556002646 dimer interface [polypeptide binding]; other site 926556002647 structural Zn2+ binding site [ion binding]; other site 926556002648 Bacterial PH domain; Region: DUF304; cl01348 926556002649 YcxB-like protein; Region: YcxB; pfam14317 926556002650 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556002651 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556002652 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 926556002653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556002654 Walker A/P-loop; other site 926556002655 ATP binding site [chemical binding]; other site 926556002656 Q-loop/lid; other site 926556002657 ABC transporter signature motif; other site 926556002658 Walker B; other site 926556002659 D-loop; other site 926556002660 H-loop/switch region; other site 926556002661 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 926556002662 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 926556002663 active site 926556002664 metal-dependent hydrolase; Provisional; Region: PRK13291 926556002665 DinB superfamily; Region: DinB_2; pfam12867 926556002666 Catalytic domain of vertebrate phospholipase D6 and similar proteins; Region: PLDc_vPLD6_like; cd09171 926556002667 PLD-like domain; Region: PLDc_2; pfam13091 926556002668 putative active site [active] 926556002669 catalytic site [active] 926556002670 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 926556002671 additional DNA contacts [nucleotide binding]; other site 926556002672 mismatch recognition site; other site 926556002673 active site 926556002674 zinc binding site [ion binding]; other site 926556002675 DNA intercalation site [nucleotide binding]; other site 926556002676 HNH endonuclease; Region: HNH_2; pfam13391 926556002677 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 926556002678 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 926556002679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926556002680 motif II; other site 926556002681 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 926556002682 DNA repair protein RadA; Provisional; Region: PRK11823 926556002683 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 926556002684 Walker A motif/ATP binding site; other site 926556002685 ATP binding site [chemical binding]; other site 926556002686 Walker B motif; other site 926556002687 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 926556002688 DNA polymerase I; Provisional; Region: PRK05755 926556002689 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 926556002690 active site 926556002691 metal binding site 1 [ion binding]; metal-binding site 926556002692 putative 5' ssDNA interaction site; other site 926556002693 metal binding site 3; metal-binding site 926556002694 metal binding site 2 [ion binding]; metal-binding site 926556002695 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 926556002696 putative DNA binding site [nucleotide binding]; other site 926556002697 putative metal binding site [ion binding]; other site 926556002698 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 926556002699 active site 926556002700 catalytic site [active] 926556002701 substrate binding site [chemical binding]; other site 926556002702 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 926556002703 active site 926556002704 DNA binding site [nucleotide binding] 926556002705 catalytic site [active] 926556002706 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 926556002707 Tic20-like protein; Region: Tic20; pfam09685 926556002708 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 926556002709 TM2 domain; Region: TM2; pfam05154 926556002710 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 926556002711 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 926556002712 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 926556002713 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 926556002714 active site 926556002715 metal binding site [ion binding]; metal-binding site 926556002716 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 926556002717 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 926556002718 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926556002719 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 926556002720 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 926556002721 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 926556002722 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 926556002723 dimerization interface [polypeptide binding]; other site 926556002724 tyrosine decarboxylase; Region: PLN02880 926556002725 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 926556002726 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926556002727 catalytic residue [active] 926556002728 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 926556002729 classical (c) SDRs; Region: SDR_c; cd05233 926556002730 NAD(P) binding site [chemical binding]; other site 926556002731 active site 926556002732 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 926556002733 active site 926556002734 metal binding site [ion binding]; metal-binding site 926556002735 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926556002736 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 926556002737 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556002738 Sulfatase; Region: Sulfatase; pfam00884 926556002739 comF family protein; Region: comF; TIGR00201 926556002740 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926556002741 active site 926556002742 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 926556002743 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 926556002744 putative active site [active] 926556002745 putative catalytic site [active] 926556002746 putative DNA binding site [nucleotide binding]; other site 926556002747 putative phosphate binding site [ion binding]; other site 926556002748 metal binding site A [ion binding]; metal-binding site 926556002749 putative AP binding site [nucleotide binding]; other site 926556002750 putative metal binding site B [ion binding]; other site 926556002751 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 926556002752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556002753 ATP binding site [chemical binding]; other site 926556002754 Mg2+ binding site [ion binding]; other site 926556002755 G-X-G motif; other site 926556002756 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 926556002757 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 926556002758 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 926556002759 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 926556002760 Methyltransferase domain; Region: Methyltransf_23; pfam13489 926556002761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556002762 S-adenosylmethionine binding site [chemical binding]; other site 926556002763 Bacterial Ig-like domain; Region: Big_5; pfam13205 926556002764 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 926556002765 Putative esterase; Region: Esterase; pfam00756 926556002766 S-formylglutathione hydrolase; Region: PLN02442 926556002767 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 926556002768 GIY-YIG motif/motif A; other site 926556002769 putative active site [active] 926556002770 putative metal binding site [ion binding]; other site 926556002771 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926556002772 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926556002773 ligand binding site [chemical binding]; other site 926556002774 flexible hinge region; other site 926556002775 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 926556002776 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 926556002777 Transcriptional regulators [Transcription]; Region: MarR; COG1846 926556002778 MarR family; Region: MarR; pfam01047 926556002779 MarR family; Region: MarR_2; cl17246 926556002780 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 926556002781 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 926556002782 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 926556002783 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 926556002784 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 926556002785 substrate binding site [chemical binding]; other site 926556002786 oxyanion hole (OAH) forming residues; other site 926556002787 trimer interface [polypeptide binding]; other site 926556002788 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 926556002789 four helix bundle protein; Region: TIGR02436 926556002790 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 926556002791 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 926556002792 dimer interface [polypeptide binding]; other site 926556002793 active site 926556002794 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 926556002795 four helix bundle protein; Region: TIGR02436 926556002796 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 926556002797 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 926556002798 active site 926556002799 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 926556002800 Transposase IS200 like; Region: Y1_Tnp; pfam01797 926556002801 Methyltransferase domain; Region: Methyltransf_23; pfam13489 926556002802 Methyltransferase domain; Region: Methyltransf_11; pfam08241 926556002803 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 926556002804 catalytic residues [active] 926556002805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926556002806 Coenzyme A binding pocket [chemical binding]; other site 926556002807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926556002808 Coenzyme A binding pocket [chemical binding]; other site 926556002809 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 926556002810 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 926556002811 active site 926556002812 putative substrate binding pocket [chemical binding]; other site 926556002813 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926556002814 maltose O-acetyltransferase; Provisional; Region: PRK10092 926556002815 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 926556002816 active site 926556002817 substrate binding site [chemical binding]; other site 926556002818 trimer interface [polypeptide binding]; other site 926556002819 CoA binding site [chemical binding]; other site 926556002820 Response regulator receiver domain; Region: Response_reg; pfam00072 926556002821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556002822 active site 926556002823 phosphorylation site [posttranslational modification] 926556002824 intermolecular recognition site; other site 926556002825 dimerization interface [polypeptide binding]; other site 926556002826 PAS fold; Region: PAS; pfam00989 926556002827 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556002828 putative active site [active] 926556002829 heme pocket [chemical binding]; other site 926556002830 PAS domain S-box; Region: sensory_box; TIGR00229 926556002831 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556002832 putative active site [active] 926556002833 heme pocket [chemical binding]; other site 926556002834 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 926556002835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556002836 putative active site [active] 926556002837 heme pocket [chemical binding]; other site 926556002838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556002839 dimer interface [polypeptide binding]; other site 926556002840 phosphorylation site [posttranslational modification] 926556002841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556002842 ATP binding site [chemical binding]; other site 926556002843 Mg2+ binding site [ion binding]; other site 926556002844 G-X-G motif; other site 926556002845 Predicted membrane protein [Function unknown]; Region: COG4270 926556002846 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 926556002847 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 926556002848 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 926556002849 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 926556002850 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 926556002851 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 926556002852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 926556002853 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 926556002854 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 926556002855 Walker A/P-loop; other site 926556002856 ATP binding site [chemical binding]; other site 926556002857 Q-loop/lid; other site 926556002858 ABC transporter signature motif; other site 926556002859 Walker B; other site 926556002860 D-loop; other site 926556002861 H-loop/switch region; other site 926556002862 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 926556002863 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 926556002864 Walker A/P-loop; other site 926556002865 ATP binding site [chemical binding]; other site 926556002866 Q-loop/lid; other site 926556002867 ABC transporter signature motif; other site 926556002868 Walker B; other site 926556002869 D-loop; other site 926556002870 H-loop/switch region; other site 926556002871 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 926556002872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926556002873 dimer interface [polypeptide binding]; other site 926556002874 conserved gate region; other site 926556002875 putative PBP binding loops; other site 926556002876 ABC-ATPase subunit interface; other site 926556002877 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 926556002878 NMT1-like family; Region: NMT1_2; pfam13379 926556002879 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556002880 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 926556002881 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926556002882 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926556002883 ligand binding site [chemical binding]; other site 926556002884 flexible hinge region; other site 926556002885 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 926556002886 putative switch regulator; other site 926556002887 non-specific DNA interactions [nucleotide binding]; other site 926556002888 DNA binding site [nucleotide binding] 926556002889 sequence specific DNA binding site [nucleotide binding]; other site 926556002890 putative cAMP binding site [chemical binding]; other site 926556002891 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 926556002892 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926556002893 Coenzyme A binding pocket [chemical binding]; other site 926556002894 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926556002895 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926556002896 ligand binding site [chemical binding]; other site 926556002897 flexible hinge region; other site 926556002898 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 926556002899 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 926556002900 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926556002901 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926556002902 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 926556002903 N-terminal plug; other site 926556002904 ligand-binding site [chemical binding]; other site 926556002905 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 926556002906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 926556002907 M28 Zn-Peptidases; Region: M28_like_2; cd05662 926556002908 Peptidase family M28; Region: Peptidase_M28; pfam04389 926556002909 metal binding site [ion binding]; metal-binding site 926556002910 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 926556002911 AAA domain; Region: AAA_28; pfam13521 926556002912 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 926556002913 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 926556002914 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 926556002915 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 926556002916 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 926556002917 active site 926556002918 Predicted permeases [General function prediction only]; Region: COG0679 926556002919 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 926556002920 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 926556002921 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 926556002922 Protein export membrane protein; Region: SecD_SecF; pfam02355 926556002923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 926556002924 Histidine kinase; Region: HisKA_3; pfam07730 926556002925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556002926 ATP binding site [chemical binding]; other site 926556002927 Mg2+ binding site [ion binding]; other site 926556002928 G-X-G motif; other site 926556002929 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926556002930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556002931 active site 926556002932 phosphorylation site [posttranslational modification] 926556002933 intermolecular recognition site; other site 926556002934 dimerization interface [polypeptide binding]; other site 926556002935 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926556002936 DNA binding residues [nucleotide binding] 926556002937 dimerization interface [polypeptide binding]; other site 926556002938 putative oxidoreductase; Provisional; Region: PRK11579 926556002939 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556002940 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 926556002941 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 926556002942 putative hydrophobic ligand binding site [chemical binding]; other site 926556002943 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926556002944 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926556002945 ligand binding site [chemical binding]; other site 926556002946 flexible hinge region; other site 926556002947 NlpE N-terminal domain; Region: NlpE; pfam04170 926556002948 Predicted membrane protein [Function unknown]; Region: COG3650 926556002949 META domain; Region: META; pfam03724 926556002950 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 926556002951 active site 926556002952 catalytic triad [active] 926556002953 oxyanion hole [active] 926556002954 AAA domain; Region: AAA_30; pfam13604 926556002955 PIF1-like helicase; Region: PIF1; pfam05970 926556002956 Family description; Region: UvrD_C_2; pfam13538 926556002957 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556002958 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556002959 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556002960 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 926556002961 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 926556002962 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 926556002963 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 926556002964 iron-sulfur cluster [ion binding]; other site 926556002965 [2Fe-2S] cluster binding site [ion binding]; other site 926556002966 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 926556002967 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 926556002968 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 926556002969 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 926556002970 Transient receptor potential (TRP) ion channel; Region: TRP; pfam06011 926556002971 Histidine kinase; Region: His_kinase; pfam06580 926556002972 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 926556002973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556002974 active site 926556002975 phosphorylation site [posttranslational modification] 926556002976 intermolecular recognition site; other site 926556002977 dimerization interface [polypeptide binding]; other site 926556002978 LytTr DNA-binding domain; Region: LytTR; smart00850 926556002979 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 926556002980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556002981 active site 926556002982 phosphorylation site [posttranslational modification] 926556002983 intermolecular recognition site; other site 926556002984 dimerization interface [polypeptide binding]; other site 926556002985 LytTr DNA-binding domain; Region: LytTR; smart00850 926556002986 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 926556002987 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 926556002988 putative active site [active] 926556002989 PhoH-like protein; Region: PhoH; pfam02562 926556002990 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556002991 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 926556002992 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 926556002993 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 926556002994 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 926556002995 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 926556002996 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926556002997 catalytic residue [active] 926556002998 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 926556002999 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 926556003000 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 926556003001 shikimate binding site; other site 926556003002 NAD(P) binding site [chemical binding]; other site 926556003003 Domain of unknown function (DUF368); Region: DUF368; pfam04018 926556003004 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 926556003005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556003006 binding surface 926556003007 TPR motif; other site 926556003008 TPR repeat; Region: TPR_11; pfam13414 926556003009 TPR repeat; Region: TPR_11; pfam13414 926556003010 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556003011 binding surface 926556003012 TPR repeat; Region: TPR_11; pfam13414 926556003013 TPR motif; other site 926556003014 TPR repeat; Region: TPR_11; pfam13414 926556003015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556003016 binding surface 926556003017 TPR motif; other site 926556003018 TPR repeat; Region: TPR_11; pfam13414 926556003019 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 926556003020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926556003021 NAD(P) binding site [chemical binding]; other site 926556003022 active site 926556003023 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 926556003024 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 926556003025 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 926556003026 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 926556003027 HflX GTPase family; Region: HflX; cd01878 926556003028 G1 box; other site 926556003029 GTP/Mg2+ binding site [chemical binding]; other site 926556003030 Switch I region; other site 926556003031 G2 box; other site 926556003032 G3 box; other site 926556003033 Switch II region; other site 926556003034 G4 box; other site 926556003035 G5 box; other site 926556003036 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 926556003037 AF-4 proto-oncoprotein; Region: AF-4; pfam05110 926556003038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556003039 S-adenosylmethionine binding site [chemical binding]; other site 926556003040 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 926556003041 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 926556003042 Transglycosylase; Region: Transgly; cl17702 926556003043 recombination protein F; Reviewed; Region: recF; PRK00064 926556003044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556003045 Walker A/P-loop; other site 926556003046 ATP binding site [chemical binding]; other site 926556003047 Q-loop/lid; other site 926556003048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556003049 ABC transporter signature motif; other site 926556003050 Walker B; other site 926556003051 D-loop; other site 926556003052 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 926556003053 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 926556003054 dimerization interface [polypeptide binding]; other site 926556003055 active site 926556003056 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 926556003057 LytTr DNA-binding domain; Region: LytTR; smart00850 926556003058 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 926556003059 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 926556003060 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 926556003061 Fn3 associated; Region: Fn3_assoc; pfam13287 926556003062 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 926556003063 sugar binding site [chemical binding]; other site 926556003064 16S rRNA methyltransferase B; Provisional; Region: PRK14901 926556003065 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 926556003066 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 926556003067 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 926556003068 generic binding surface II; other site 926556003069 ssDNA binding site; other site 926556003070 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926556003071 ATP binding site [chemical binding]; other site 926556003072 putative Mg++ binding site [ion binding]; other site 926556003073 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926556003074 nucleotide binding region [chemical binding]; other site 926556003075 ATP-binding site [chemical binding]; other site 926556003076 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 926556003077 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 926556003078 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 926556003079 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 926556003080 dimer interface [polypeptide binding]; other site 926556003081 active site 926556003082 heme binding site [chemical binding]; other site 926556003083 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 926556003084 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 926556003085 Zn binding site [ion binding]; other site 926556003086 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 926556003087 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 926556003088 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 926556003089 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 926556003090 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 926556003091 dimer interface [polypeptide binding]; other site 926556003092 active site 926556003093 metal binding site [ion binding]; metal-binding site 926556003094 Repair protein; Region: Repair_PSII; pfam04536 926556003095 Repair protein; Region: Repair_PSII; pfam04536 926556003096 LemA family; Region: LemA; pfam04011 926556003097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556003098 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 926556003099 putative active site [active] 926556003100 heme pocket [chemical binding]; other site 926556003101 PAS domain; Region: PAS_9; pfam13426 926556003102 PAS fold; Region: PAS_4; pfam08448 926556003103 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556003104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556003105 dimer interface [polypeptide binding]; other site 926556003106 phosphorylation site [posttranslational modification] 926556003107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556003108 ATP binding site [chemical binding]; other site 926556003109 Mg2+ binding site [ion binding]; other site 926556003110 G-X-G motif; other site 926556003111 Aspartyl protease; Region: Asp_protease_2; pfam13650 926556003112 inhibitor binding site; inhibition site 926556003113 catalytic motif [active] 926556003114 Catalytic residue [active] 926556003115 Active site flap [active] 926556003116 Aspartyl protease; Region: Asp_protease_2; pfam13650 926556003117 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 926556003118 protein binding site [polypeptide binding]; other site 926556003119 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 926556003120 metal binding site 2 [ion binding]; metal-binding site 926556003121 putative DNA binding helix; other site 926556003122 metal binding site 1 [ion binding]; metal-binding site 926556003123 dimer interface [polypeptide binding]; other site 926556003124 structural Zn2+ binding site [ion binding]; other site 926556003125 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 926556003126 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 926556003127 Cl- selectivity filter; other site 926556003128 Cl- binding residues [ion binding]; other site 926556003129 pore gating glutamate residue; other site 926556003130 dimer interface [polypeptide binding]; other site 926556003131 FOG: CBS domain [General function prediction only]; Region: COG0517 926556003132 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 926556003133 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 926556003134 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 926556003135 homodimer interface [polypeptide binding]; other site 926556003136 metal binding site [ion binding]; metal-binding site 926556003137 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 926556003138 homodimer interface [polypeptide binding]; other site 926556003139 active site 926556003140 putative chemical substrate binding site [chemical binding]; other site 926556003141 metal binding site [ion binding]; metal-binding site 926556003142 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 926556003143 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 926556003144 active site 926556003145 substrate binding site [chemical binding]; other site 926556003146 metal binding site [ion binding]; metal-binding site 926556003147 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 926556003148 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 926556003149 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926556003150 catalytic residue [active] 926556003151 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 926556003152 active site 926556003153 dimerization interface [polypeptide binding]; other site 926556003154 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 926556003155 dephospho-CoA kinase; Region: TIGR00152 926556003156 ATP-binding site [chemical binding]; other site 926556003157 Sugar specificity; other site 926556003158 Pyrimidine base specificity; other site 926556003159 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 926556003160 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 926556003161 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 926556003162 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 926556003163 dimer interface [polypeptide binding]; other site 926556003164 active site 926556003165 glycine-pyridoxal phosphate binding site [chemical binding]; other site 926556003166 folate binding site [chemical binding]; other site 926556003167 serine racemase; Region: PLN02970 926556003168 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 926556003169 tetramer interface [polypeptide binding]; other site 926556003170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556003171 catalytic residue [active] 926556003172 Peptidase family M23; Region: Peptidase_M23; pfam01551 926556003173 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 926556003174 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926556003175 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 926556003176 Walker A/P-loop; other site 926556003177 ATP binding site [chemical binding]; other site 926556003178 Q-loop/lid; other site 926556003179 ABC transporter signature motif; other site 926556003180 Walker B; other site 926556003181 D-loop; other site 926556003182 H-loop/switch region; other site 926556003183 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 926556003184 putative active site [active] 926556003185 Zn binding site [ion binding]; other site 926556003186 Transposase IS200 like; Region: Y1_Tnp; pfam01797 926556003187 RecX family; Region: RecX; pfam02631 926556003188 triosephosphate isomerase; Provisional; Region: PRK14567 926556003189 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 926556003190 substrate binding site [chemical binding]; other site 926556003191 dimer interface [polypeptide binding]; other site 926556003192 catalytic triad [active] 926556003193 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 926556003194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556003195 S-adenosylmethionine binding site [chemical binding]; other site 926556003196 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 926556003197 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 926556003198 active site 926556003199 nucleophile elbow; other site 926556003200 Methyltransferase domain; Region: Methyltransf_31; pfam13847 926556003201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556003202 S-adenosylmethionine binding site [chemical binding]; other site 926556003203 Predicted membrane protein [Function unknown]; Region: COG2860 926556003204 UPF0126 domain; Region: UPF0126; pfam03458 926556003205 UPF0126 domain; Region: UPF0126; pfam03458 926556003206 hypothetical protein; Validated; Region: PRK09104 926556003207 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 926556003208 metal binding site [ion binding]; metal-binding site 926556003209 putative dimer interface [polypeptide binding]; other site 926556003210 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 926556003211 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 926556003212 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556003213 Predicted membrane protein [Function unknown]; Region: COG2855 926556003214 Transcriptional regulator [Transcription]; Region: LysR; COG0583 926556003215 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 926556003216 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 926556003217 putative dimerization interface [polypeptide binding]; other site 926556003218 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 926556003219 N-acetyl-D-glucosamine binding site [chemical binding]; other site 926556003220 catalytic residue [active] 926556003221 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 926556003222 Flagellin N-methylase; Region: FliB; pfam03692 926556003223 geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169 926556003224 phosphate binding site [ion binding]; other site 926556003225 Helix-turn-helix domain; Region: HTH_18; pfam12833 926556003226 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 926556003227 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 926556003228 active site 926556003229 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926556003230 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 926556003231 excinuclease ABC subunit B; Provisional; Region: PRK05298 926556003232 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926556003233 ATP binding site [chemical binding]; other site 926556003234 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926556003235 nucleotide binding region [chemical binding]; other site 926556003236 ATP-binding site [chemical binding]; other site 926556003237 Ultra-violet resistance protein B; Region: UvrB; pfam12344 926556003238 UvrB/uvrC motif; Region: UVR; pfam02151 926556003239 Divergent AAA domain; Region: AAA_4; pfam04326 926556003240 aspartate kinase III; Validated; Region: PRK09084 926556003241 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 926556003242 nucleotide binding site [chemical binding]; other site 926556003243 substrate binding site [chemical binding]; other site 926556003244 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 926556003245 dimer interface [polypeptide binding]; other site 926556003246 allosteric regulatory binding pocket; other site 926556003247 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 926556003248 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 926556003249 homopentamer interface [polypeptide binding]; other site 926556003250 active site 926556003251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556003252 TPR motif; other site 926556003253 binding surface 926556003254 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926556003255 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 926556003256 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 926556003257 tetramer interface [polypeptide binding]; other site 926556003258 TPP-binding site [chemical binding]; other site 926556003259 heterodimer interface [polypeptide binding]; other site 926556003260 phosphorylation loop region [posttranslational modification] 926556003261 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 926556003262 active site 926556003263 DinB superfamily; Region: DinB_2; pfam12867 926556003264 DinB family; Region: DinB; cl17821 926556003265 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 926556003266 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 926556003267 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 926556003268 Na binding site [ion binding]; other site 926556003269 Phosphotransferase enzyme family; Region: APH; pfam01636 926556003270 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 926556003271 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556003272 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556003273 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556003274 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556003275 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556003276 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556003277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556003278 putative substrate translocation pore; other site 926556003279 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926556003280 TfoX N-terminal domain; Region: TfoX_N; cl17592 926556003281 MutS domain III; Region: MutS_III; pfam05192 926556003282 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556003283 Walker A/P-loop; other site 926556003284 ATP binding site [chemical binding]; other site 926556003285 Q-loop/lid; other site 926556003286 ABC transporter signature motif; other site 926556003287 Walker B; other site 926556003288 D-loop; other site 926556003289 H-loop/switch region; other site 926556003290 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 926556003291 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926556003292 dimer interface [polypeptide binding]; other site 926556003293 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 926556003294 putative FMN binding site [chemical binding]; other site 926556003295 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 926556003296 catalytic residues [active] 926556003297 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 926556003298 hypothetical protein; Provisional; Region: PRK12378 926556003299 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 926556003300 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926556003301 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 926556003302 putative active site pocket [active] 926556003303 dimerization interface [polypeptide binding]; other site 926556003304 putative catalytic residue [active] 926556003305 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 926556003306 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 926556003307 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926556003308 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 926556003309 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 926556003310 active site 926556003311 dimer interface [polypeptide binding]; other site 926556003312 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 926556003313 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 926556003314 active site 926556003315 FMN binding site [chemical binding]; other site 926556003316 substrate binding site [chemical binding]; other site 926556003317 3Fe-4S cluster binding site [ion binding]; other site 926556003318 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 926556003319 domain interface; other site 926556003320 gliding motility-associated protein GldE; Region: GldE; TIGR03520 926556003321 Domain of unknown function DUF21; Region: DUF21; pfam01595 926556003322 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 926556003323 Transporter associated domain; Region: CorC_HlyC; smart01091 926556003324 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 926556003325 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 926556003326 dimer interface [polypeptide binding]; other site 926556003327 ssDNA binding site [nucleotide binding]; other site 926556003328 tetramer (dimer of dimers) interface [polypeptide binding]; other site 926556003329 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 926556003330 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 926556003331 minor groove reading motif; other site 926556003332 helix-hairpin-helix signature motif; other site 926556003333 substrate binding pocket [chemical binding]; other site 926556003334 active site 926556003335 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 926556003336 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 926556003337 DNA binding and oxoG recognition site [nucleotide binding] 926556003338 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 926556003339 IHF dimer interface [polypeptide binding]; other site 926556003340 IHF - DNA interface [nucleotide binding]; other site 926556003341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556003342 TPR motif; other site 926556003343 Tetratricopeptide repeat; Region: TPR_16; pfam13432 926556003344 binding surface 926556003345 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 926556003346 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 926556003347 homodimer interface [polypeptide binding]; other site 926556003348 oligonucleotide binding site [chemical binding]; other site 926556003349 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 926556003350 Type III pantothenate kinase; Region: Pan_kinase; cl17198 926556003351 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926556003352 Coenzyme A binding pocket [chemical binding]; other site 926556003353 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 926556003354 beta-carotene hydroxylase; Region: PLN02601 926556003355 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 926556003356 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 926556003357 DNA binding residues [nucleotide binding] 926556003358 B12 binding domain; Region: B12-binding_2; pfam02607 926556003359 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 926556003360 B12 binding site [chemical binding]; other site 926556003361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926556003362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926556003363 Bacterial transcriptional repressor; Region: TetR; pfam13972 926556003364 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 926556003365 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 926556003366 SelR domain; Region: SelR; pfam01641 926556003367 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556003368 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 926556003369 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 926556003370 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 926556003371 active site 926556003372 dimer interface [polypeptide binding]; other site 926556003373 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 926556003374 Ligand Binding Site [chemical binding]; other site 926556003375 Molecular Tunnel; other site 926556003376 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 926556003377 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 926556003378 minor groove reading motif; other site 926556003379 helix-hairpin-helix signature motif; other site 926556003380 substrate binding pocket [chemical binding]; other site 926556003381 active site 926556003382 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 926556003383 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 926556003384 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 926556003385 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 926556003386 Na binding site [ion binding]; other site 926556003387 acetyl-CoA synthetase; Provisional; Region: PRK00174 926556003388 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 926556003389 active site 926556003390 CoA binding site [chemical binding]; other site 926556003391 acyl-activating enzyme (AAE) consensus motif; other site 926556003392 AMP binding site [chemical binding]; other site 926556003393 acetate binding site [chemical binding]; other site 926556003394 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 926556003395 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926556003396 ligand binding site [chemical binding]; other site 926556003397 flexible hinge region; other site 926556003398 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 926556003399 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 926556003400 metal binding triad; other site 926556003401 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 926556003402 active site 926556003403 catalytic site [active] 926556003404 substrate binding site [chemical binding]; other site 926556003405 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 926556003406 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 926556003407 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 926556003408 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 926556003409 hexamer (dimer of trimers) interface [polypeptide binding]; other site 926556003410 trimer interface [polypeptide binding]; other site 926556003411 substrate binding site [chemical binding]; other site 926556003412 Mn binding site [ion binding]; other site 926556003413 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 926556003414 Na binding site [ion binding]; other site 926556003415 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 926556003416 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 926556003417 inhibitor site; inhibition site 926556003418 active site 926556003419 dimer interface [polypeptide binding]; other site 926556003420 catalytic residue [active] 926556003421 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 926556003422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926556003423 Coenzyme A binding pocket [chemical binding]; other site 926556003424 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 926556003425 Active site serine [active] 926556003426 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 926556003427 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 926556003428 nucleotide binding site [chemical binding]; other site 926556003429 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 926556003430 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 926556003431 TM-ABC transporter signature motif; other site 926556003432 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 926556003433 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 926556003434 Walker A/P-loop; other site 926556003435 ATP binding site [chemical binding]; other site 926556003436 Q-loop/lid; other site 926556003437 ABC transporter signature motif; other site 926556003438 Walker B; other site 926556003439 D-loop; other site 926556003440 H-loop/switch region; other site 926556003441 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 926556003442 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 926556003443 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 926556003444 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 926556003445 ligand binding site [chemical binding]; other site 926556003446 dimerization interface [polypeptide binding]; other site 926556003447 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 926556003448 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 926556003449 PYR/PP interface [polypeptide binding]; other site 926556003450 dimer interface [polypeptide binding]; other site 926556003451 TPP binding site [chemical binding]; other site 926556003452 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 926556003453 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 926556003454 transketolase; Reviewed; Region: PRK05899 926556003455 TPP-binding site [chemical binding]; other site 926556003456 dimer interface [polypeptide binding]; other site 926556003457 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 926556003458 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 926556003459 hexamer (dimer of trimers) interface [polypeptide binding]; other site 926556003460 substrate binding site [chemical binding]; other site 926556003461 trimer interface [polypeptide binding]; other site 926556003462 Mn binding site [ion binding]; other site 926556003463 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556003464 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556003465 SusD family; Region: SusD; pfam07980 926556003466 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556003467 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556003468 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556003469 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556003470 Equine arteritis virus GP3; Region: GP3; pfam03076 926556003471 FecR protein; Region: FecR; pfam04773 926556003472 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 926556003473 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 926556003474 acyl-activating enzyme (AAE) consensus motif; other site 926556003475 AMP binding site [chemical binding]; other site 926556003476 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 926556003477 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 926556003478 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 926556003479 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926556003480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556003481 active site 926556003482 phosphorylation site [posttranslational modification] 926556003483 intermolecular recognition site; other site 926556003484 dimerization interface [polypeptide binding]; other site 926556003485 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 926556003486 DNA binding site [nucleotide binding] 926556003487 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556003488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556003489 dimer interface [polypeptide binding]; other site 926556003490 phosphorylation site [posttranslational modification] 926556003491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556003492 ATP binding site [chemical binding]; other site 926556003493 Mg2+ binding site [ion binding]; other site 926556003494 G-X-G motif; other site 926556003495 diaminopimelate decarboxylase; Region: lysA; TIGR01048 926556003496 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 926556003497 active site 926556003498 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926556003499 substrate binding site [chemical binding]; other site 926556003500 catalytic residues [active] 926556003501 dimer interface [polypeptide binding]; other site 926556003502 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 926556003503 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 926556003504 HIGH motif; other site 926556003505 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 926556003506 active site 926556003507 KMSKS motif; other site 926556003508 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926556003509 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 926556003510 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 926556003511 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 926556003512 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 926556003513 Glutamate binding site [chemical binding]; other site 926556003514 NAD binding site [chemical binding]; other site 926556003515 catalytic residues [active] 926556003516 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 926556003517 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926556003518 motif II; other site 926556003519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926556003520 dimerization interface [polypeptide binding]; other site 926556003521 putative DNA binding site [nucleotide binding]; other site 926556003522 putative Zn2+ binding site [ion binding]; other site 926556003523 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556003524 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926556003525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556003526 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 926556003527 DNA binding residues [nucleotide binding] 926556003528 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 926556003529 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 926556003530 active site 926556003531 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 926556003532 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 926556003533 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 926556003534 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926556003535 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 926556003536 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926556003537 gliding motility-associated lipoprotein GldJ; Region: GldJ_short; TIGR03530 926556003538 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 926556003539 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 926556003540 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 926556003541 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 926556003542 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926556003543 ATP binding site [chemical binding]; other site 926556003544 putative Mg++ binding site [ion binding]; other site 926556003545 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926556003546 nucleotide binding region [chemical binding]; other site 926556003547 ATP-binding site [chemical binding]; other site 926556003548 TRCF domain; Region: TRCF; pfam03461 926556003549 Subunit I/III interface [polypeptide binding]; other site 926556003550 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 926556003551 Methyltransferase domain; Region: Methyltransf_23; pfam13489 926556003552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556003553 S-adenosylmethionine binding site [chemical binding]; other site 926556003554 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 926556003555 Bacterial sugar transferase; Region: Bac_transf; pfam02397 926556003556 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 926556003557 Fasciclin domain; Region: Fasciclin; pfam02469 926556003558 Fasciclin domain; Region: Fasciclin; pfam02469 926556003559 Fasciclin domain; Region: Fasciclin; pfam02469 926556003560 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 926556003561 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 926556003562 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 926556003563 Pectic acid lyase; Region: Pec_lyase; pfam09492 926556003564 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556003565 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556003566 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556003567 DNA binding residues [nucleotide binding] 926556003568 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556003569 FecR protein; Region: FecR; pfam04773 926556003570 Secretin and TonB N terminus short domain; Region: STN; pfam07660 926556003571 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556003572 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556003573 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556003574 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556003575 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556003576 SusD family; Region: SusD; pfam07980 926556003577 Pectate lyase; Region: Pec_lyase_C; cl01593 926556003578 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 926556003579 homotrimer interaction site [polypeptide binding]; other site 926556003580 putative active site [active] 926556003581 fumarate hydratase; Reviewed; Region: fumC; PRK00485 926556003582 Class II fumarases; Region: Fumarase_classII; cd01362 926556003583 active site 926556003584 tetramer interface [polypeptide binding]; other site 926556003585 Sporulation related domain; Region: SPOR; cl10051 926556003586 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 926556003587 active site 926556003588 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 926556003589 DHH family; Region: DHH; pfam01368 926556003590 DHHA1 domain; Region: DHHA1; pfam02272 926556003591 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 926556003592 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 926556003593 Walker A/P-loop; other site 926556003594 ATP binding site [chemical binding]; other site 926556003595 Q-loop/lid; other site 926556003596 ABC transporter signature motif; other site 926556003597 Walker B; other site 926556003598 D-loop; other site 926556003599 H-loop/switch region; other site 926556003600 GH3 auxin-responsive promoter; Region: GH3; pfam03321 926556003601 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926556003602 Ligand Binding Site [chemical binding]; other site 926556003603 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 926556003604 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 926556003605 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 926556003606 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 926556003607 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 926556003608 RimM N-terminal domain; Region: RimM; pfam01782 926556003609 PRC-barrel domain; Region: PRC; pfam05239 926556003610 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 926556003611 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 926556003612 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 926556003613 GIY-YIG motif/motif A; other site 926556003614 putative active site [active] 926556003615 putative metal binding site [ion binding]; other site 926556003616 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 926556003617 GIY-YIG motif/motif A; other site 926556003618 putative active site [active] 926556003619 putative metal binding site [ion binding]; other site 926556003620 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 926556003621 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 926556003622 catalytic residues [active] 926556003623 catalytic nucleophile [active] 926556003624 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 926556003625 MPN+ (JAMM) motif; other site 926556003626 Zinc-binding site [ion binding]; other site 926556003627 Domain of unknown function (DUF932); Region: DUF932; pfam06067 926556003628 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 926556003629 active site 926556003630 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 926556003631 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 926556003632 Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780 926556003633 Domain of unknown function (DUF4138); Region: DUF4138; pfam13595 926556003634 Protein of unknown function (DUF3714); Region: DUF3714; pfam12508 926556003635 Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781 926556003636 Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782 926556003637 Uncharacterized conserved protein [Function unknown]; Region: COG4301 926556003638 Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991 926556003639 Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783 926556003640 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 926556003641 Domain of unknown function (DUF4133); Region: DUF4133; pfam13571 926556003642 Domain of unknown function (DUF4134); Region: DUF4134; pfam13572 926556003643 RteC protein; Region: RteC; pfam09357 926556003644 LytTr DNA-binding domain; Region: LytTR; smart00850 926556003645 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926556003646 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 926556003647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 926556003648 DNA-binding site [nucleotide binding]; DNA binding site 926556003649 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926556003650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556003651 homodimer interface [polypeptide binding]; other site 926556003652 catalytic residue [active] 926556003653 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926556003654 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556003655 catalytic residues [active] 926556003656 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556003657 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556003658 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556003659 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556003660 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556003661 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556003662 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556003663 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 926556003664 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926556003665 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 926556003666 FecR protein; Region: FecR; pfam04773 926556003667 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556003668 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556003669 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556003670 DNA binding residues [nucleotide binding] 926556003671 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 926556003672 YWFCY protein; Region: YWFCY; pfam14293 926556003673 AAA-like domain; Region: AAA_10; pfam12846 926556003674 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 926556003675 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 926556003676 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 926556003677 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 926556003678 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926556003679 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556003680 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 926556003681 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 926556003682 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 926556003683 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 926556003684 Chromate transporter; Region: Chromate_transp; pfam02417 926556003685 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 926556003686 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 926556003687 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 926556003688 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556003689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556003690 dimer interface [polypeptide binding]; other site 926556003691 phosphorylation site [posttranslational modification] 926556003692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556003693 ATP binding site [chemical binding]; other site 926556003694 Mg2+ binding site [ion binding]; other site 926556003695 G-X-G motif; other site 926556003696 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926556003697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556003698 active site 926556003699 phosphorylation site [posttranslational modification] 926556003700 intermolecular recognition site; other site 926556003701 dimerization interface [polypeptide binding]; other site 926556003702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926556003703 DNA binding site [nucleotide binding] 926556003704 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 926556003705 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 926556003706 catalytic residues [active] 926556003707 catalytic nucleophile [active] 926556003708 Recombinase; Region: Recombinase; pfam07508 926556003709 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 926556003710 Outer membrane efflux protein; Region: OEP; pfam02321 926556003711 Outer membrane efflux protein; Region: OEP; pfam02321 926556003712 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 926556003713 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 926556003714 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556003715 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 926556003716 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 926556003717 DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172 926556003718 DGQHR domain; Region: DGQHR; TIGR03187 926556003719 DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172 926556003720 Transposase; Region: HTH_Tnp_1; pfam01527 926556003721 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 926556003722 Integrase core domain; Region: rve; pfam00665 926556003723 Integrase core domain; Region: rve_3; pfam13683 926556003724 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 926556003725 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 926556003726 active site 926556003727 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926556003728 SnoaL-like domain; Region: SnoaL_2; pfam12680 926556003729 RibD C-terminal domain; Region: RibD_C; cl17279 926556003730 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 926556003731 DinB superfamily; Region: DinB_2; pfam12867 926556003732 metal-dependent hydrolase; Provisional; Region: PRK13291 926556003733 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926556003734 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 926556003735 dimer interface [polypeptide binding]; other site 926556003736 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 926556003737 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 926556003738 conserved cys residue [active] 926556003739 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 926556003740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556003741 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 926556003742 active site 926556003743 Zn binding site [ion binding]; other site 926556003744 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 926556003745 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 926556003746 metal binding site [ion binding]; metal-binding site 926556003747 dimer interface [polypeptide binding]; other site 926556003748 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 926556003749 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 926556003750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 926556003751 nucleotide binding region [chemical binding]; other site 926556003752 ATP-binding site [chemical binding]; other site 926556003753 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 926556003754 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 926556003755 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 926556003756 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 926556003757 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 926556003758 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 926556003759 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 926556003760 metal binding site [ion binding]; metal-binding site 926556003761 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 926556003762 homodimer interface [polypeptide binding]; other site 926556003763 homotetramer interface [polypeptide binding]; other site 926556003764 active site pocket [active] 926556003765 cleavage site 926556003766 Transcriptional regulators [Transcription]; Region: MarR; COG1846 926556003767 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 926556003768 Inner membrane protein CreD; Region: CreD; pfam06123 926556003769 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 926556003770 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 926556003771 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926556003772 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 926556003773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926556003774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926556003775 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 926556003776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556003777 S-adenosylmethionine binding site [chemical binding]; other site 926556003778 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 926556003779 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 926556003780 peptide chain release factor 1; Validated; Region: prfA; PRK00591 926556003781 This domain is found in peptide chain release factors; Region: PCRF; smart00937 926556003782 RF-1 domain; Region: RF-1; pfam00472 926556003783 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 926556003784 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 926556003785 kynureninase; Region: kynureninase; TIGR01814 926556003786 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 926556003787 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926556003788 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926556003789 catalytic residue [active] 926556003790 catalytic residue [active] 926556003791 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 926556003792 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 926556003793 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 926556003794 Predicted membrane protein [Function unknown]; Region: COG2259 926556003795 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926556003796 active site 926556003797 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 926556003798 Nitrogen regulatory protein P-II; Region: P-II; smart00938 926556003799 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 926556003800 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 926556003801 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926556003802 Chromate transporter; Region: Chromate_transp; pfam02417 926556003803 Chromate transporter; Region: Chromate_transp; pfam02417 926556003804 oxidase reductase; Provisional; Region: PTZ00273 926556003805 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 926556003806 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 926556003807 Recombination protein O N terminal; Region: RecO_N; pfam11967 926556003808 Recombination protein O C terminal; Region: RecO_C; pfam02565 926556003809 thymidine kinase; Provisional; Region: PRK04296 926556003810 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 926556003811 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 926556003812 catalytic loop [active] 926556003813 iron binding site [ion binding]; other site 926556003814 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556003815 Sulfatase; Region: Sulfatase; pfam00884 926556003816 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 926556003817 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 926556003818 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 926556003819 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 926556003820 rod shape-determining protein MreC; Provisional; Region: PRK13922 926556003821 rod shape-determining protein MreC; Region: MreC; pfam04085 926556003822 rod shape-determining protein MreB; Provisional; Region: PRK13927 926556003823 MreB and similar proteins; Region: MreB_like; cd10225 926556003824 nucleotide binding site [chemical binding]; other site 926556003825 Mg binding site [ion binding]; other site 926556003826 putative protofilament interaction site [polypeptide binding]; other site 926556003827 RodZ interaction site [polypeptide binding]; other site 926556003828 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 926556003829 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 926556003830 purine monophosphate binding site [chemical binding]; other site 926556003831 dimer interface [polypeptide binding]; other site 926556003832 putative catalytic residues [active] 926556003833 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 926556003834 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 926556003835 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 926556003836 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 926556003837 active site 926556003838 substrate binding site [chemical binding]; other site 926556003839 cosubstrate binding site; other site 926556003840 catalytic site [active] 926556003841 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 926556003842 UbiA prenyltransferase family; Region: UbiA; pfam01040 926556003843 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 926556003844 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 926556003845 NAD binding site [chemical binding]; other site 926556003846 homodimer interface [polypeptide binding]; other site 926556003847 active site 926556003848 substrate binding site [chemical binding]; other site 926556003849 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 926556003850 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 926556003851 active site 926556003852 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 926556003853 ApbE family; Region: ApbE; pfam02424 926556003854 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926556003855 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556003856 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556003857 DNA binding residues [nucleotide binding] 926556003858 phytoene desaturase; Region: crtI_fam; TIGR02734 926556003859 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 926556003860 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 926556003861 active site lid residues [active] 926556003862 substrate binding pocket [chemical binding]; other site 926556003863 catalytic residues [active] 926556003864 substrate-Mg2+ binding site; other site 926556003865 aspartate-rich region 1; other site 926556003866 aspartate-rich region 2; other site 926556003867 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 926556003868 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 926556003869 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 926556003870 LytB protein; Region: LYTB; cl00507 926556003871 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 926556003872 Fatty acid desaturase; Region: FA_desaturase; pfam00487 926556003873 putative di-iron ligands [ion binding]; other site 926556003874 Surface antigen; Region: Bac_surface_Ag; pfam01103 926556003875 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556003876 MgtC family; Region: MgtC; pfam02308 926556003877 Lamin Tail Domain; Region: LTD; pfam00932 926556003878 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 926556003879 CotH protein; Region: CotH; pfam08757 926556003880 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926556003881 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 926556003882 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 926556003883 active site 926556003884 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 926556003885 homodimer interface [polypeptide binding]; other site 926556003886 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 926556003887 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 926556003888 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926556003889 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 926556003890 active site 926556003891 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926556003892 dimer interface [polypeptide binding]; other site 926556003893 substrate binding site [chemical binding]; other site 926556003894 catalytic residues [active] 926556003895 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 926556003896 dimer interface [polypeptide binding]; other site 926556003897 putative tRNA-binding site [nucleotide binding]; other site 926556003898 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 926556003899 Zn binding site [ion binding]; other site 926556003900 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 926556003901 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 926556003902 NAD(P) binding site [chemical binding]; other site 926556003903 catalytic residues [active] 926556003904 conserved repeat domain; Region: B_ant_repeat; TIGR01451 926556003905 Domain of unknown function DUF11; Region: DUF11; pfam01345 926556003906 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926556003907 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 926556003908 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926556003909 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926556003910 ligand binding site [chemical binding]; other site 926556003911 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926556003912 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926556003913 ligand binding site [chemical binding]; other site 926556003914 Sporulation related domain; Region: SPOR; pfam05036 926556003915 TspO/MBR family; Region: TspO_MBR; pfam03073 926556003916 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 926556003917 putative hydrophobic ligand binding site [chemical binding]; other site 926556003918 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 926556003919 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 926556003920 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 926556003921 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 926556003922 homotrimer interaction site [polypeptide binding]; other site 926556003923 zinc binding site [ion binding]; other site 926556003924 CDP-binding sites; other site 926556003925 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 926556003926 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 926556003927 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 926556003928 Heavy-metal-associated domain; Region: HMA; pfam00403 926556003929 metal-binding site [ion binding] 926556003930 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 926556003931 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926556003932 metal-binding site [ion binding] 926556003933 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926556003934 Soluble P-type ATPase [General function prediction only]; Region: COG4087 926556003935 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 926556003936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 926556003937 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 926556003938 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 926556003939 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 926556003940 Oxygen tolerance; Region: BatD; pfam13584 926556003941 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 926556003942 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 926556003943 Tetramer interface [polypeptide binding]; other site 926556003944 active site 926556003945 FMN-binding site [chemical binding]; other site 926556003946 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 926556003947 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 926556003948 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 926556003949 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 926556003950 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 926556003951 Peptidase family M23; Region: Peptidase_M23; pfam01551 926556003952 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 926556003953 EamA-like transporter family; Region: EamA; pfam00892 926556003954 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 926556003955 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 926556003956 glutaminase active site [active] 926556003957 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 926556003958 dimer interface [polypeptide binding]; other site 926556003959 active site 926556003960 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 926556003961 dimer interface [polypeptide binding]; other site 926556003962 active site 926556003963 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 926556003964 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 926556003965 pantoate--beta-alanine ligase; Region: panC; TIGR00018 926556003966 Pantoate-beta-alanine ligase; Region: PanC; cd00560 926556003967 active site 926556003968 ATP-binding site [chemical binding]; other site 926556003969 pantoate-binding site; other site 926556003970 HXXH motif; other site 926556003971 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 926556003972 tetramerization interface [polypeptide binding]; other site 926556003973 active site 926556003974 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 926556003975 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 926556003976 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 926556003977 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 926556003978 FMN binding site [chemical binding]; other site 926556003979 active site 926556003980 catalytic residues [active] 926556003981 substrate binding site [chemical binding]; other site 926556003982 CAAX protease self-immunity; Region: Abi; pfam02517 926556003983 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 926556003984 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 926556003985 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 926556003986 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 926556003987 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 926556003988 NAD(P) binding site [chemical binding]; other site 926556003989 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 926556003990 Ribosome-binding factor A; Region: RBFA; pfam02033 926556003991 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 926556003992 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926556003993 FtsX-like permease family; Region: FtsX; pfam02687 926556003994 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 926556003995 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 926556003996 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926556003997 ATP binding site [chemical binding]; other site 926556003998 putative Mg++ binding site [ion binding]; other site 926556003999 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926556004000 nucleotide binding region [chemical binding]; other site 926556004001 ATP-binding site [chemical binding]; other site 926556004002 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 926556004003 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 926556004004 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 926556004005 putative active site [active] 926556004006 putative substrate binding site [chemical binding]; other site 926556004007 putative cosubstrate binding site; other site 926556004008 catalytic site [active] 926556004009 META domain; Region: META; cl01245 926556004010 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 926556004011 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 926556004012 active site 926556004013 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926556004014 dimer interface [polypeptide binding]; other site 926556004015 substrate binding site [chemical binding]; other site 926556004016 catalytic residues [active] 926556004017 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 926556004018 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like3; cd05668 926556004019 metal binding site [ion binding]; metal-binding site 926556004020 putative dimer interface [polypeptide binding]; other site 926556004021 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926556004022 putative DNA binding site [nucleotide binding]; other site 926556004023 putative Zn2+ binding site [ion binding]; other site 926556004024 Outer membrane efflux protein; Region: OEP; pfam02321 926556004025 Outer membrane efflux protein; Region: OEP; pfam02321 926556004026 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926556004027 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926556004028 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556004029 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 926556004030 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 926556004031 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 926556004032 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 926556004033 active site 926556004034 MoxR-like ATPases [General function prediction only]; Region: COG0714 926556004035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556004036 Walker A motif; other site 926556004037 ATP binding site [chemical binding]; other site 926556004038 Walker B motif; other site 926556004039 arginine finger; other site 926556004040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556004041 Walker A/P-loop; other site 926556004042 ATP binding site [chemical binding]; other site 926556004043 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556004044 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 926556004045 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556004046 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556004047 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 926556004048 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926556004049 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926556004050 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 926556004051 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 926556004052 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 926556004053 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 926556004054 protein binding site [polypeptide binding]; other site 926556004055 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 926556004056 Domain interface; other site 926556004057 Peptide binding site; other site 926556004058 Active site tetrad [active] 926556004059 Domain of unknown function DUF21; Region: DUF21; pfam01595 926556004060 FOG: CBS domain [General function prediction only]; Region: COG0517 926556004061 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 926556004062 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 926556004063 Domain of unknown function DUF20; Region: UPF0118; pfam01594 926556004064 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 926556004065 Ion transport protein; Region: Ion_trans; pfam00520 926556004066 Ion channel; Region: Ion_trans_2; pfam07885 926556004067 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 926556004068 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 926556004069 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 926556004070 TrkA-N domain; Region: TrkA_N; pfam02254 926556004071 TrkA-C domain; Region: TrkA_C; pfam02080 926556004072 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 926556004073 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 926556004074 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 926556004075 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 926556004076 Cysteine-rich domain; Region: CCG; pfam02754 926556004077 Cysteine-rich domain; Region: CCG; pfam02754 926556004078 putative alpha-glucosidase; Provisional; Region: PRK10658 926556004079 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 926556004080 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 926556004081 active site 926556004082 catalytic site [active] 926556004083 short chain dehydrogenase; Validated; Region: PRK08324 926556004084 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 926556004085 active site 926556004086 Zn2+ binding site [ion binding]; other site 926556004087 intersubunit interface [polypeptide binding]; other site 926556004088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926556004089 NAD(P) binding site [chemical binding]; other site 926556004090 active site 926556004091 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 926556004092 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 926556004093 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 926556004094 nucleotide binding site [chemical binding]; other site 926556004095 Transposase IS200 like; Region: Y1_Tnp; cl00848 926556004096 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556004097 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556004098 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 926556004099 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 926556004100 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 926556004101 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 926556004102 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 926556004103 active site 926556004104 catalytic triad [active] 926556004105 oxyanion hole [active] 926556004106 switch loop; other site 926556004107 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926556004108 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926556004109 Walker A/P-loop; other site 926556004110 ATP binding site [chemical binding]; other site 926556004111 Q-loop/lid; other site 926556004112 ABC transporter signature motif; other site 926556004113 Walker B; other site 926556004114 D-loop; other site 926556004115 H-loop/switch region; other site 926556004116 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 926556004117 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926556004118 FtsX-like permease family; Region: FtsX; pfam02687 926556004119 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 926556004120 MarR family; Region: MarR_2; pfam12802 926556004121 Uncharacterized conserved protein [Function unknown]; Region: COG2353 926556004122 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 926556004123 Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199 926556004124 active site 926556004125 ligand binding site [chemical binding]; other site 926556004126 NAD(P) binding site [chemical binding]; other site 926556004127 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 926556004128 intersubunit interface [polypeptide binding]; other site 926556004129 active site 926556004130 catalytic residue [active] 926556004131 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 926556004132 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926556004133 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 926556004134 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 926556004135 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 926556004136 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 926556004137 nucleoside/Zn binding site; other site 926556004138 dimer interface [polypeptide binding]; other site 926556004139 catalytic motif [active] 926556004140 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 926556004141 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 926556004142 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 926556004143 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926556004144 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926556004145 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556004146 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556004147 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 926556004148 putative active site [active] 926556004149 putative catalytic site [active] 926556004150 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 926556004151 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 926556004152 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 926556004153 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 926556004154 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 926556004155 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 926556004156 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 926556004157 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 926556004158 ATP binding site [chemical binding]; other site 926556004159 putative Mg++ binding site [ion binding]; other site 926556004160 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926556004161 nucleotide binding region [chemical binding]; other site 926556004162 ATP-binding site [chemical binding]; other site 926556004163 DbpA RNA binding domain; Region: DbpA; pfam03880 926556004164 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 926556004165 Haem-binding domain; Region: Haem_bd; pfam14376 926556004166 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 926556004167 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 926556004168 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 926556004169 metal ion-dependent adhesion site (MIDAS); other site 926556004170 Acylphosphatase; Region: Acylphosphatase; pfam00708 926556004171 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556004172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556004173 dimer interface [polypeptide binding]; other site 926556004174 phosphorylation site [posttranslational modification] 926556004175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556004176 ATP binding site [chemical binding]; other site 926556004177 Mg2+ binding site [ion binding]; other site 926556004178 G-X-G motif; other site 926556004179 Response regulator receiver domain; Region: Response_reg; pfam00072 926556004180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556004181 active site 926556004182 phosphorylation site [posttranslational modification] 926556004183 intermolecular recognition site; other site 926556004184 dimerization interface [polypeptide binding]; other site 926556004185 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 926556004186 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 926556004187 putative active site [active] 926556004188 Zn binding site [ion binding]; other site 926556004189 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 926556004190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926556004191 TIGR01777 family protein; Region: yfcH 926556004192 NAD(P) binding site [chemical binding]; other site 926556004193 active site 926556004194 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 926556004195 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 926556004196 putative Cl- selectivity filter; other site 926556004197 putative pore gating glutamate residue; other site 926556004198 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 926556004199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 926556004200 DNA-binding site [nucleotide binding]; DNA binding site 926556004201 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926556004202 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 926556004203 putative dimerization interface [polypeptide binding]; other site 926556004204 putative ligand binding site [chemical binding]; other site 926556004205 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 926556004206 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926556004207 Na binding site [ion binding]; other site 926556004208 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 926556004209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 926556004210 DNA-binding site [nucleotide binding]; DNA binding site 926556004211 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926556004212 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 926556004213 putative dimerization interface [polypeptide binding]; other site 926556004214 putative ligand binding site [chemical binding]; other site 926556004215 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556004216 Domain of unknown function (DUF718); Region: DUF718; pfam05336 926556004217 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556004218 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556004219 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556004220 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 926556004221 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556004222 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556004223 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556004224 Glycosyl hydrolase 43-like family consists of hypothetical proteins; Region: GH43_like_2; cd08994 926556004225 active site 926556004226 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 926556004227 Protein of unknown function, DUF608; Region: DUF608; pfam04685 926556004228 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 926556004229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 926556004230 DNA-binding site [nucleotide binding]; DNA binding site 926556004231 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926556004232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556004233 homodimer interface [polypeptide binding]; other site 926556004234 catalytic residue [active] 926556004235 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 926556004236 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 926556004237 homodimer interface [polypeptide binding]; other site 926556004238 substrate-cofactor binding pocket; other site 926556004239 catalytic residue [active] 926556004240 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926556004241 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 926556004242 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 926556004243 oligomer interface [polypeptide binding]; other site 926556004244 active site residues [active] 926556004245 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 926556004246 active site 926556004247 catalytic triad [active] 926556004248 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 926556004249 active site 926556004250 catalytic triad [active] 926556004251 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 926556004252 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 926556004253 Transposase; Region: DEDD_Tnp_IS110; pfam01548 926556004254 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 926556004255 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 926556004256 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556004257 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556004258 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556004259 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556004260 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556004261 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556004262 SusD family; Region: SusD; pfam07980 926556004263 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 926556004264 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 926556004265 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 926556004266 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 926556004267 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 926556004268 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 926556004269 putative active site [active] 926556004270 putative metal binding site [ion binding]; other site 926556004271 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 926556004272 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 926556004273 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 926556004274 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 926556004275 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 926556004276 Two component regulator propeller; Region: Reg_prop; pfam07494 926556004277 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 926556004278 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556004279 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556004280 dimer interface [polypeptide binding]; other site 926556004281 phosphorylation site [posttranslational modification] 926556004282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556004283 ATP binding site [chemical binding]; other site 926556004284 Mg2+ binding site [ion binding]; other site 926556004285 G-X-G motif; other site 926556004286 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926556004287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556004288 active site 926556004289 phosphorylation site [posttranslational modification] 926556004290 intermolecular recognition site; other site 926556004291 dimerization interface [polypeptide binding]; other site 926556004292 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 926556004293 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556004294 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926556004295 FOG: PKD repeat [General function prediction only]; Region: COG3291 926556004296 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926556004297 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926556004298 Fasciclin domain; Region: Fasciclin; cl02663 926556004299 Fasciclin domain; Region: Fasciclin; cl02663 926556004300 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556004301 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556004302 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556004303 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556004304 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556004305 Fasciclin domain; Region: Fasciclin; pfam02469 926556004306 Fasciclin domain; Region: Fasciclin; cl02663 926556004307 Fasciclin domain; Region: Fasciclin; pfam02469 926556004308 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556004309 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556004310 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556004311 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556004312 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556004313 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556004314 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 926556004315 metal binding site [ion binding]; metal-binding site 926556004316 active site 926556004317 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 926556004318 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 926556004319 active site 926556004320 catalytic triad [active] 926556004321 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 926556004322 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 926556004323 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 926556004324 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 926556004325 BNR repeat-like domain; Region: BNR_2; pfam13088 926556004326 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 926556004327 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556004328 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 926556004329 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 926556004330 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 926556004331 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 926556004332 metal binding site [ion binding]; metal-binding site 926556004333 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 926556004334 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556004335 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 926556004336 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 926556004337 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 926556004338 Protein of unknown function (DUF998); Region: DUF998; pfam06197 926556004339 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 926556004340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556004341 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556004342 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556004343 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556004344 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556004345 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556004346 SusD family; Region: SusD; pfam07980 926556004347 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556004348 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556004349 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556004350 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556004351 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556004352 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556004353 SusD family; Region: SusD; pfam07980 926556004354 Right handed beta helix region; Region: Beta_helix; pfam13229 926556004355 putative alpha-glucosidase; Provisional; Region: PRK10658 926556004356 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 926556004357 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 926556004358 active site 926556004359 catalytic site [active] 926556004360 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556004361 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556004362 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 926556004363 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 926556004364 putative transporter; Provisional; Region: PRK10484 926556004365 Na binding site [ion binding]; other site 926556004366 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 926556004367 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556004368 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 926556004369 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 926556004370 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 926556004371 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 926556004372 active site 2 [active] 926556004373 active site 1 [active] 926556004374 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 926556004375 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 926556004376 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 926556004377 CoA-transferase family III; Region: CoA_transf_3; pfam02515 926556004378 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 926556004379 CoA-transferase family III; Region: CoA_transf_3; pfam02515 926556004380 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 926556004381 Amidohydrolase; Region: Amidohydro_2; pfam04909 926556004382 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 926556004383 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556004384 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556004385 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 926556004386 metal binding site [ion binding]; metal-binding site 926556004387 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 926556004388 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 926556004389 dimer interface [polypeptide binding]; other site 926556004390 active site 926556004391 catalytic residue [active] 926556004392 metal binding site [ion binding]; metal-binding site 926556004393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 926556004394 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 926556004395 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 926556004396 Sodium Bile acid symporter family; Region: SBF; cl17470 926556004397 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 926556004398 substrate binding pocket [chemical binding]; other site 926556004399 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 926556004400 Ion channel; Region: Ion_trans_2; pfam07885 926556004401 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 926556004402 membrane-bound complex binding site; other site 926556004403 hinge residues; other site 926556004404 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 926556004405 active site 926556004406 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 926556004407 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556004408 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 926556004409 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 926556004410 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 926556004411 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 926556004412 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556004413 Domain of unknown function (DUF303); Region: DUF303; pfam03629 926556004414 Fic family protein [Function unknown]; Region: COG3177 926556004415 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 926556004416 Fic/DOC family; Region: Fic; pfam02661 926556004417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 926556004418 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 926556004419 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 926556004420 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556004421 Walker A/P-loop; other site 926556004422 ATP binding site [chemical binding]; other site 926556004423 Q-loop/lid; other site 926556004424 Apx/Shroom domain ASD2; Region: ASD2; pfam08687 926556004425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556004426 ABC transporter signature motif; other site 926556004427 Walker B; other site 926556004428 D-loop; other site 926556004429 H-loop/switch region; other site 926556004430 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 926556004431 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 926556004432 active site 926556004433 metal binding site [ion binding]; metal-binding site 926556004434 DNA binding site [nucleotide binding] 926556004435 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 926556004436 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 926556004437 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 926556004438 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926556004439 Peptidase family M23; Region: Peptidase_M23; pfam01551 926556004440 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556004441 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 926556004442 Protein export membrane protein; Region: SecD_SecF; cl14618 926556004443 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 926556004444 Domain of unknown function (DUF368); Region: DUF368; cl00893 926556004445 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 926556004446 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 926556004447 substrate binding site [chemical binding]; other site 926556004448 active site 926556004449 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926556004450 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926556004451 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 926556004452 Walker A/P-loop; other site 926556004453 ATP binding site [chemical binding]; other site 926556004454 Q-loop/lid; other site 926556004455 ABC transporter signature motif; other site 926556004456 Walker B; other site 926556004457 D-loop; other site 926556004458 H-loop/switch region; other site 926556004459 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 926556004460 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 926556004461 dimerization interface 3.5A [polypeptide binding]; other site 926556004462 active site 926556004463 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 926556004464 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 926556004465 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556004466 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 926556004467 DNA binding residues [nucleotide binding] 926556004468 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 926556004469 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 926556004470 homodimer interface [polypeptide binding]; other site 926556004471 substrate-cofactor binding pocket; other site 926556004472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556004473 catalytic residue [active] 926556004474 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 926556004475 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 926556004476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556004477 Walker A motif; other site 926556004478 ATP binding site [chemical binding]; other site 926556004479 Walker B motif; other site 926556004480 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 926556004481 Protein trafficking PGA2; Region: PGA2; pfam07543 926556004482 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926556004483 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926556004484 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 926556004485 Walker A/P-loop; other site 926556004486 ATP binding site [chemical binding]; other site 926556004487 Q-loop/lid; other site 926556004488 ABC transporter signature motif; other site 926556004489 Walker B; other site 926556004490 D-loop; other site 926556004491 H-loop/switch region; other site 926556004492 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 926556004493 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 926556004494 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 926556004495 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 926556004496 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 926556004497 DNA polymerase III subunit delta'; Validated; Region: PRK08485 926556004498 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 926556004499 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 926556004500 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 926556004501 ATP-grasp domain; Region: ATP-grasp_4; cl17255 926556004502 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 926556004503 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 926556004504 domain interfaces; other site 926556004505 active site 926556004506 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 926556004507 active site 926556004508 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 926556004509 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 926556004510 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 926556004511 NADP binding site [chemical binding]; other site 926556004512 active site 926556004513 putative substrate binding site [chemical binding]; other site 926556004514 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 926556004515 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 926556004516 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926556004517 Helix-turn-helix domain; Region: HTH_18; pfam12833 926556004518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556004519 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 926556004520 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 926556004521 tetramer interface [polypeptide binding]; other site 926556004522 TPP-binding site [chemical binding]; other site 926556004523 heterodimer interface [polypeptide binding]; other site 926556004524 phosphorylation loop region [posttranslational modification] 926556004525 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 926556004526 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 926556004527 alpha subunit interface [polypeptide binding]; other site 926556004528 TPP binding site [chemical binding]; other site 926556004529 heterodimer interface [polypeptide binding]; other site 926556004530 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 926556004531 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 926556004532 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 926556004533 MOSC domain; Region: MOSC; pfam03473 926556004534 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 926556004535 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 926556004536 nucleotide binding site [chemical binding]; other site 926556004537 NEF interaction site [polypeptide binding]; other site 926556004538 SBD interface [polypeptide binding]; other site 926556004539 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 926556004540 oligomerisation interface [polypeptide binding]; other site 926556004541 mobile loop; other site 926556004542 roof hairpin; other site 926556004543 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926556004544 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926556004545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556004546 Walker A/P-loop; other site 926556004547 ATP binding site [chemical binding]; other site 926556004548 Q-loop/lid; other site 926556004549 ABC transporter signature motif; other site 926556004550 Walker B; other site 926556004551 D-loop; other site 926556004552 H-loop/switch region; other site 926556004553 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 926556004554 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 926556004555 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 926556004556 NAD binding site [chemical binding]; other site 926556004557 Phe binding site; other site 926556004558 transcription antitermination factor NusB; Region: nusB; TIGR01951 926556004559 YtxH-like protein; Region: YtxH; cl02079 926556004560 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 926556004561 Preprotein translocase subunit; Region: YajC; pfam02699 926556004562 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 926556004563 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 926556004564 CoA-binding site [chemical binding]; other site 926556004565 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 926556004566 NlpC/P60 family; Region: NLPC_P60; pfam00877 926556004567 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 926556004568 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 926556004569 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 926556004570 alpha subunit interaction interface [polypeptide binding]; other site 926556004571 Walker A motif; other site 926556004572 ATP binding site [chemical binding]; other site 926556004573 Walker B motif; other site 926556004574 inhibitor binding site; inhibition site 926556004575 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 926556004576 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 926556004577 gamma subunit interface [polypeptide binding]; other site 926556004578 LBP interface [polypeptide binding]; other site 926556004579 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 926556004580 amphipathic channel; other site 926556004581 Asn-Pro-Ala signature motifs; other site 926556004582 glycerol kinase; Provisional; Region: glpK; PRK00047 926556004583 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 926556004584 N- and C-terminal domain interface [polypeptide binding]; other site 926556004585 active site 926556004586 MgATP binding site [chemical binding]; other site 926556004587 catalytic site [active] 926556004588 metal binding site [ion binding]; metal-binding site 926556004589 glycerol binding site [chemical binding]; other site 926556004590 homotetramer interface [polypeptide binding]; other site 926556004591 homodimer interface [polypeptide binding]; other site 926556004592 FBP binding site [chemical binding]; other site 926556004593 protein IIAGlc interface [polypeptide binding]; other site 926556004594 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 926556004595 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 926556004596 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 926556004597 ATP cone domain; Region: ATP-cone; pfam03477 926556004598 Class I ribonucleotide reductase; Region: RNR_I; cd01679 926556004599 active site 926556004600 dimer interface [polypeptide binding]; other site 926556004601 catalytic residues [active] 926556004602 effector binding site; other site 926556004603 R2 peptide binding site; other site 926556004604 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 926556004605 dimer interface [polypeptide binding]; other site 926556004606 putative radical transfer pathway; other site 926556004607 diiron center [ion binding]; other site 926556004608 tyrosyl radical; other site 926556004609 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 926556004610 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 926556004611 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 926556004612 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556004613 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 926556004614 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 926556004615 putative active site [active] 926556004616 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926556004617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556004618 Walker A/P-loop; other site 926556004619 ATP binding site [chemical binding]; other site 926556004620 Q-loop/lid; other site 926556004621 ABC transporter signature motif; other site 926556004622 Walker B; other site 926556004623 D-loop; other site 926556004624 H-loop/switch region; other site 926556004625 HTH domain; Region: HTH_11; pfam08279 926556004626 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 926556004627 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 926556004628 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 926556004629 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 926556004630 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 926556004631 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 926556004632 DoxX; Region: DoxX; pfam07681 926556004633 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 926556004634 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 926556004635 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 926556004636 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 926556004637 ribonuclease P; Reviewed; Region: rnpA; PRK01903 926556004638 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 926556004639 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 926556004640 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 926556004641 protein binding site [polypeptide binding]; other site 926556004642 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 926556004643 Catalytic dyad [active] 926556004644 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 926556004645 Glycoprotease family; Region: Peptidase_M22; pfam00814 926556004646 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 926556004647 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 926556004648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556004649 Walker A/P-loop; other site 926556004650 ATP binding site [chemical binding]; other site 926556004651 Q-loop/lid; other site 926556004652 ABC transporter signature motif; other site 926556004653 Walker B; other site 926556004654 D-loop; other site 926556004655 H-loop/switch region; other site 926556004656 ABC transporter; Region: ABC_tran_2; pfam12848 926556004657 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926556004658 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 926556004659 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 926556004660 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 926556004661 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 926556004662 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 926556004663 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 926556004664 active site residue [active] 926556004665 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 926556004666 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 926556004667 putative trimer interface [polypeptide binding]; other site 926556004668 putative CoA binding site [chemical binding]; other site 926556004669 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 926556004670 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 926556004671 active site 926556004672 dimer interface [polypeptide binding]; other site 926556004673 DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120 926556004674 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 926556004675 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 926556004676 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 926556004677 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 926556004678 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 926556004679 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 926556004680 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 926556004681 quinone interaction residues [chemical binding]; other site 926556004682 active site 926556004683 catalytic residues [active] 926556004684 FMN binding site [chemical binding]; other site 926556004685 substrate binding site [chemical binding]; other site 926556004686 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 926556004687 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 926556004688 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 926556004689 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 926556004690 active site 926556004691 Int/Topo IB signature motif; other site 926556004692 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 926556004693 Dehydroquinase class II; Region: DHquinase_II; pfam01220 926556004694 active site 926556004695 trimer interface [polypeptide binding]; other site 926556004696 dimer interface [polypeptide binding]; other site 926556004697 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 926556004698 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 926556004699 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926556004700 catalytic residue [active] 926556004701 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 926556004702 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 926556004703 RNA/DNA hybrid binding site [nucleotide binding]; other site 926556004704 active site 926556004705 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 926556004706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556004707 S-adenosylmethionine binding site [chemical binding]; other site 926556004708 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 926556004709 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 926556004710 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 926556004711 active site 926556004712 catalytic motif [active] 926556004713 Zn binding site [ion binding]; other site 926556004714 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926556004715 Trehalose utilisation; Region: ThuA; pfam06283 926556004716 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 926556004717 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 926556004718 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 926556004719 putative NAD(P) binding site [chemical binding]; other site 926556004720 homodimer interface [polypeptide binding]; other site 926556004721 homotetramer interface [polypeptide binding]; other site 926556004722 active site 926556004723 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926556004724 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 926556004725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556004726 S-adenosylmethionine binding site [chemical binding]; other site 926556004727 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 926556004728 G1 box; other site 926556004729 GTP/Mg2+ binding site [chemical binding]; other site 926556004730 Switch I region; other site 926556004731 G2 box; other site 926556004732 G3 box; other site 926556004733 Switch II region; other site 926556004734 G4 box; other site 926556004735 G5 box; other site 926556004736 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 926556004737 AMP binding site [chemical binding]; other site 926556004738 metal binding site [ion binding]; metal-binding site 926556004739 active site 926556004740 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 926556004741 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 926556004742 nucleotide binding site [chemical binding]; other site 926556004743 substrate binding site [chemical binding]; other site 926556004744 Fructosamine kinase; Region: Fructosamin_kin; cl17579 926556004745 Phosphotransferase enzyme family; Region: APH; pfam01636 926556004746 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 926556004747 Low molecular weight phosphatase family; Region: LMWPc; cd00115 926556004748 active site 926556004749 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 926556004750 metal binding site 2 [ion binding]; metal-binding site 926556004751 putative DNA binding helix; other site 926556004752 metal binding site 1 [ion binding]; metal-binding site 926556004753 dimer interface [polypeptide binding]; other site 926556004754 structural Zn2+ binding site [ion binding]; other site 926556004755 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 926556004756 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 926556004757 dimer interface [polypeptide binding]; other site 926556004758 decamer (pentamer of dimers) interface [polypeptide binding]; other site 926556004759 catalytic triad [active] 926556004760 peroxidatic and resolving cysteines [active] 926556004761 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 926556004762 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 926556004763 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 926556004764 GTPase RsgA; Reviewed; Region: PRK00098 926556004765 RNA binding site [nucleotide binding]; other site 926556004766 homodimer interface [polypeptide binding]; other site 926556004767 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 926556004768 GTPase/Zn-binding domain interface [polypeptide binding]; other site 926556004769 GTP/Mg2+ binding site [chemical binding]; other site 926556004770 G4 box; other site 926556004771 G5 box; other site 926556004772 G1 box; other site 926556004773 Switch I region; other site 926556004774 G2 box; other site 926556004775 G3 box; other site 926556004776 Switch II region; other site 926556004777 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 926556004778 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926556004779 active site 926556004780 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 926556004781 active site 926556004782 oligomerization interface [polypeptide binding]; other site 926556004783 metal binding site [ion binding]; metal-binding site 926556004784 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 926556004785 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 926556004786 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 926556004787 Cytochrome c; Region: Cytochrom_C; cl11414 926556004788 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 926556004789 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 926556004790 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556004791 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556004792 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 926556004793 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 926556004794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556004795 putative substrate translocation pore; other site 926556004796 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 926556004797 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 926556004798 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 926556004799 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 926556004800 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 926556004801 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 926556004802 Tetratricopeptide repeat; Region: TPR_16; pfam13432 926556004803 Bacterial SH3 domain; Region: SH3_4; pfam06347 926556004804 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 926556004805 active site 926556004806 catalytic residues [active] 926556004807 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 926556004808 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556004809 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556004810 SusD family; Region: SusD; pfam07980 926556004811 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556004812 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556004813 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556004814 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556004815 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 926556004816 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926556004817 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 926556004818 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 926556004819 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926556004820 DNA binding residues [nucleotide binding] 926556004821 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 926556004822 Peptidase family M28; Region: Peptidase_M28; pfam04389 926556004823 metal binding site [ion binding]; metal-binding site 926556004824 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 926556004825 classical (c) SDRs; Region: SDR_c; cd05233 926556004826 NAD(P) binding site [chemical binding]; other site 926556004827 active site 926556004828 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 926556004829 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 926556004830 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 926556004831 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926556004832 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926556004833 DNA binding site [nucleotide binding] 926556004834 domain linker motif; other site 926556004835 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 926556004836 dimerization interface [polypeptide binding]; other site 926556004837 ligand binding site [chemical binding]; other site 926556004838 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556004839 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556004840 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556004841 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556004842 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556004843 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556004844 SusD family; Region: SusD; pfam07980 926556004845 mannonate dehydratase; Provisional; Region: PRK03906 926556004846 mannonate dehydratase; Region: uxuA; TIGR00695 926556004847 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 926556004848 Na binding site [ion binding]; other site 926556004849 substrate binding site [chemical binding]; other site 926556004850 Cupin domain; Region: Cupin_2; pfam07883 926556004851 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 926556004852 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556004853 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 926556004854 D-xylulose kinase; Region: XylB; TIGR01312 926556004855 nucleotide binding site [chemical binding]; other site 926556004856 xylose isomerase; Provisional; Region: PRK05474 926556004857 xylose isomerase; Region: xylose_isom_A; TIGR02630 926556004858 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 926556004859 substrate binding site [chemical binding]; other site 926556004860 active site 926556004861 L-arabinose isomerase; Provisional; Region: PRK02929 926556004862 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 926556004863 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 926556004864 trimer interface [polypeptide binding]; other site 926556004865 putative substrate binding site [chemical binding]; other site 926556004866 putative metal binding site [ion binding]; other site 926556004867 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 926556004868 Na binding site [ion binding]; other site 926556004869 substrate binding site [chemical binding]; other site 926556004870 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 926556004871 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 926556004872 nudix motif; other site 926556004873 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 926556004874 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926556004875 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 926556004876 dimer interface [polypeptide binding]; other site 926556004877 putative metal binding site [ion binding]; other site 926556004878 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 926556004879 C-terminal peptidase (prc); Region: prc; TIGR00225 926556004880 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 926556004881 protein binding site [polypeptide binding]; other site 926556004882 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 926556004883 Catalytic dyad [active] 926556004884 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 926556004885 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 926556004886 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 926556004887 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 926556004888 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 926556004889 active site 926556004890 catalytic residues [active] 926556004891 metal binding site [ion binding]; metal-binding site 926556004892 C-N hydrolase family amidase; Provisional; Region: PRK10438 926556004893 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 926556004894 putative active site [active] 926556004895 catalytic triad [active] 926556004896 dimer interface [polypeptide binding]; other site 926556004897 multimer interface [polypeptide binding]; other site 926556004898 Family description; Region: VCBS; pfam13517 926556004899 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926556004900 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 926556004901 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 926556004902 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926556004903 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 926556004904 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 926556004905 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 926556004906 dimer interface [polypeptide binding]; other site 926556004907 putative functional site; other site 926556004908 putative MPT binding site; other site 926556004909 hypothetical protein; Validated; Region: PRK07411 926556004910 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 926556004911 ATP binding site [chemical binding]; other site 926556004912 substrate interface [chemical binding]; other site 926556004913 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926556004914 active site residue [active] 926556004915 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 926556004916 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 926556004917 GTP binding site; other site 926556004918 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 926556004919 trimer interface [polypeptide binding]; other site 926556004920 dimer interface [polypeptide binding]; other site 926556004921 putative active site [active] 926556004922 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 926556004923 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926556004924 FeS/SAM binding site; other site 926556004925 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 926556004926 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 926556004927 MoaE homodimer interface [polypeptide binding]; other site 926556004928 MoaD interaction [polypeptide binding]; other site 926556004929 active site residues [active] 926556004930 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 926556004931 MoaE interaction surface [polypeptide binding]; other site 926556004932 MoeB interaction surface [polypeptide binding]; other site 926556004933 thiocarboxylated glycine; other site 926556004934 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926556004935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556004936 active site 926556004937 phosphorylation site [posttranslational modification] 926556004938 intermolecular recognition site; other site 926556004939 dimerization interface [polypeptide binding]; other site 926556004940 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926556004941 DNA binding residues [nucleotide binding] 926556004942 dimerization interface [polypeptide binding]; other site 926556004943 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 926556004944 PAS domain; Region: PAS_9; pfam13426 926556004945 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 926556004946 Histidine kinase; Region: HisKA_3; pfam07730 926556004947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556004948 ATP binding site [chemical binding]; other site 926556004949 Mg2+ binding site [ion binding]; other site 926556004950 G-X-G motif; other site 926556004951 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 926556004952 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 926556004953 nitrite reductase subunit NirD; Provisional; Region: PRK14989 926556004954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926556004955 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926556004956 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 926556004957 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 926556004958 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 926556004959 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 926556004960 active site 926556004961 SAM binding site [chemical binding]; other site 926556004962 homodimer interface [polypeptide binding]; other site 926556004963 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 926556004964 Domain of unknown function (DUF4202); Region: DUF4202; pfam13875 926556004965 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 926556004966 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 926556004967 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 926556004968 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 926556004969 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 926556004970 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 926556004971 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 926556004972 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 926556004973 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 926556004974 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 926556004975 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 926556004976 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926556004977 nucleotide binding site [chemical binding]; other site 926556004978 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 926556004979 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 926556004980 Rubredoxin [Energy production and conversion]; Region: COG1773 926556004981 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 926556004982 iron binding site [ion binding]; other site 926556004983 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 926556004984 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 926556004985 [4Fe-4S] binding site [ion binding]; other site 926556004986 molybdopterin cofactor binding site; other site 926556004987 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 926556004988 molybdopterin cofactor binding site; other site 926556004989 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 926556004990 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926556004991 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 926556004992 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 926556004993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556004994 putative substrate translocation pore; other site 926556004995 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 926556004996 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926556004997 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 926556004998 active site 926556004999 motif I; other site 926556005000 motif II; other site 926556005001 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926556005002 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 926556005003 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 926556005004 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 926556005005 FOG: PKD repeat [General function prediction only]; Region: COG3291 926556005006 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926556005007 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 926556005008 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 926556005009 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926556005010 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926556005011 TIGR01666 family membrane protein; Region: YCCS 926556005012 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 926556005013 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 926556005014 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556005015 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556005016 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 926556005017 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556005018 Secretin and TonB N terminus short domain; Region: STN; pfam07660 926556005019 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556005020 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556005021 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556005022 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556005023 FecR protein; Region: FecR; pfam04773 926556005024 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556005025 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556005026 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556005027 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556005028 DNA binding residues [nucleotide binding] 926556005029 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 926556005030 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 926556005031 catalytic residues [active] 926556005032 catalytic nucleophile [active] 926556005033 Recombinase; Region: Recombinase; pfam07508 926556005034 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 926556005035 MPN+ (JAMM) motif; other site 926556005036 Zinc-binding site [ion binding]; other site 926556005037 Domain of unknown function (DUF932); Region: DUF932; pfam06067 926556005038 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 926556005039 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 926556005040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556005041 AAA domain; Region: AAA_23; pfam13476 926556005042 Walker A/P-loop; other site 926556005043 ATP binding site [chemical binding]; other site 926556005044 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 926556005045 putative active site [active] 926556005046 putative metal-binding site [ion binding]; other site 926556005047 YaaC-like Protein; Region: YaaC; pfam14175 926556005048 Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780 926556005049 Domain of unknown function (DUF4138); Region: DUF4138; pfam13595 926556005050 Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779 926556005051 Protein of unknown function (DUF3714); Region: DUF3714; pfam12508 926556005052 Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781 926556005053 Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782 926556005054 Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991 926556005055 Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783 926556005056 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 926556005057 Domain of unknown function (DUF4133); Region: DUF4133; pfam13571 926556005058 Domain of unknown function (DUF4134); Region: DUF4134; pfam13572 926556005059 RteC protein; Region: RteC; pfam09357 926556005060 LytTr DNA-binding domain; Region: LytTR; smart00850 926556005061 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926556005062 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 926556005063 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 926556005064 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926556005065 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 926556005066 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 926556005067 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 926556005068 RHS Repeat; Region: RHS_repeat; pfam05593 926556005069 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 926556005070 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 926556005071 DNA-binding site [nucleotide binding]; DNA binding site 926556005072 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 926556005073 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926556005074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556005075 homodimer interface [polypeptide binding]; other site 926556005076 catalytic residue [active] 926556005077 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556005078 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556005079 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556005080 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556005081 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556005082 FecR protein; Region: FecR; pfam04773 926556005083 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556005084 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556005085 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556005086 DNA binding residues [nucleotide binding] 926556005087 YWFCY protein; Region: YWFCY; pfam14293 926556005088 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 926556005089 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 926556005090 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 926556005091 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 926556005092 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 926556005093 Z1 domain; Region: Z1; pfam10593 926556005094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556005095 ATP binding site [chemical binding]; other site 926556005096 Mg2+ binding site [ion binding]; other site 926556005097 G-X-G motif; other site 926556005098 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 926556005099 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 926556005100 cofactor binding site; other site 926556005101 DNA binding site [nucleotide binding] 926556005102 substrate interaction site [chemical binding]; other site 926556005103 recombination protein RecR; Reviewed; Region: recR; PRK00076 926556005104 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 926556005105 DNA binding site [nucleotide binding] 926556005106 RecR protein; Region: RecR; pfam02132 926556005107 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 926556005108 putative active site [active] 926556005109 putative metal-binding site [ion binding]; other site 926556005110 tetramer interface [polypeptide binding]; other site 926556005111 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 926556005112 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 926556005113 Na binding site [ion binding]; other site 926556005114 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 926556005115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556005116 non-specific DNA binding site [nucleotide binding]; other site 926556005117 salt bridge; other site 926556005118 sequence-specific DNA binding site [nucleotide binding]; other site 926556005119 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 926556005120 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 926556005121 DNA binding site [nucleotide binding] 926556005122 active site 926556005123 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 926556005124 Mechanosensitive ion channel; Region: MS_channel; pfam00924 926556005125 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 926556005126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926556005127 NAD(P) binding site [chemical binding]; other site 926556005128 active site 926556005129 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 926556005130 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 926556005131 META domain; Region: META; pfam03724 926556005132 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 926556005133 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 926556005134 putative catalytic residues [active] 926556005135 putative nucleotide binding site [chemical binding]; other site 926556005136 putative aspartate binding site [chemical binding]; other site 926556005137 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 926556005138 dimer interface [polypeptide binding]; other site 926556005139 putative threonine allosteric regulatory site; other site 926556005140 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 926556005141 putative threonine allosteric regulatory site; other site 926556005142 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 926556005143 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 926556005144 homoserine kinase; Provisional; Region: PRK01212 926556005145 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 926556005146 threonine synthase; Validated; Region: PRK09225 926556005147 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 926556005148 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926556005149 catalytic residue [active] 926556005150 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 926556005151 Tropomyosin like; Region: Tropomyosin_1; pfam12718 926556005152 Selenoprotein S (SelS); Region: Selenoprotein_S; pfam06936 926556005153 Penicillinase repressor; Region: Pencillinase_R; pfam03965 926556005154 NRDE protein; Region: NRDE; cl01315 926556005155 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 926556005156 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 926556005157 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 926556005158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556005159 dimer interface [polypeptide binding]; other site 926556005160 phosphorylation site [posttranslational modification] 926556005161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556005162 ATP binding site [chemical binding]; other site 926556005163 Mg2+ binding site [ion binding]; other site 926556005164 G-X-G motif; other site 926556005165 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 926556005166 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926556005167 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 926556005168 active site 926556005169 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 926556005170 cytidylate kinase; Provisional; Region: cmk; PRK00023 926556005171 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 926556005172 CMP-binding site; other site 926556005173 The sites determining sugar specificity; other site 926556005174 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 926556005175 LytB protein; Region: LYTB; cl00507 926556005176 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 926556005177 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 926556005178 lipoyl-biotinyl attachment site [posttranslational modification]; other site 926556005179 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 926556005180 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 926556005181 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 926556005182 FMN-binding domain; Region: FMN_bind; cl01081 926556005183 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 926556005184 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 926556005185 Protein of unknown function (DUF502); Region: DUF502; cl01107 926556005186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 926556005187 Transposase; Region: DEDD_Tnp_IS110; pfam01548 926556005188 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 926556005189 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 926556005190 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556005191 catalytic residues [active] 926556005192 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 926556005193 active site 926556005194 catalytic site [active] 926556005195 substrate binding site [chemical binding]; other site 926556005196 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 926556005197 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 926556005198 active site 926556005199 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 926556005200 generic binding surface II; other site 926556005201 generic binding surface I; other site 926556005202 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 926556005203 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 926556005204 active site 926556005205 homotetramer interface [polypeptide binding]; other site 926556005206 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 926556005207 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 926556005208 AAA ATPase domain; Region: AAA_16; pfam13191 926556005209 Predicted ATPase [General function prediction only]; Region: COG3899 926556005210 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926556005211 GAF domain; Region: GAF; pfam01590 926556005212 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 926556005213 Histidine kinase; Region: HisKA_3; pfam07730 926556005214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556005215 ATP binding site [chemical binding]; other site 926556005216 Mg2+ binding site [ion binding]; other site 926556005217 G-X-G motif; other site 926556005218 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 926556005219 Na binding site [ion binding]; other site 926556005220 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 926556005221 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926556005222 Interdomain contacts; other site 926556005223 Cytokine receptor motif; other site 926556005224 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 926556005225 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 926556005226 putative active site [active] 926556005227 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 926556005228 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 926556005229 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 926556005230 amidase catalytic site [active] 926556005231 Zn binding residues [ion binding]; other site 926556005232 substrate binding site [chemical binding]; other site 926556005233 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926556005234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556005235 active site 926556005236 phosphorylation site [posttranslational modification] 926556005237 intermolecular recognition site; other site 926556005238 dimerization interface [polypeptide binding]; other site 926556005239 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926556005240 DNA binding residues [nucleotide binding] 926556005241 dimerization interface [polypeptide binding]; other site 926556005242 HflC protein; Region: hflC; TIGR01932 926556005243 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 926556005244 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 926556005245 HflK protein; Region: hflK; TIGR01933 926556005246 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556005247 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556005248 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556005249 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556005250 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556005251 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556005252 SusD family; Region: SusD; pfam07980 926556005253 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 926556005254 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 926556005255 NodB motif; other site 926556005256 active site 926556005257 catalytic site [active] 926556005258 metal binding site [ion binding]; metal-binding site 926556005259 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 926556005260 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 926556005261 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 926556005262 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 926556005263 Beta-lactamase; Region: Beta-lactamase; cl17358 926556005264 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 926556005265 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 926556005266 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 926556005267 active site 926556005268 metal binding site [ion binding]; metal-binding site 926556005269 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 926556005270 Trp docking motif [polypeptide binding]; other site 926556005271 PQQ-like domain; Region: PQQ_2; pfam13360 926556005272 active site 926556005273 PQQ-like domain; Region: PQQ_2; pfam13360 926556005274 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 926556005275 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926556005276 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926556005277 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 926556005278 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 926556005279 active site 926556005280 substrate binding site [chemical binding]; other site 926556005281 trimer interface [polypeptide binding]; other site 926556005282 CoA binding site [chemical binding]; other site 926556005283 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 926556005284 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 926556005285 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 926556005286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556005287 S-adenosylmethionine binding site [chemical binding]; other site 926556005288 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 926556005289 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556005290 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556005291 DNA binding residues [nucleotide binding] 926556005292 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 926556005293 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926556005294 active site 926556005295 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 926556005296 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 926556005297 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 926556005298 Predicted permeases [General function prediction only]; Region: COG0795 926556005299 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 926556005300 EamA-like transporter family; Region: EamA; pfam00892 926556005301 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609 926556005302 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 926556005303 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 926556005304 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 926556005305 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 926556005306 PYR/PP interface [polypeptide binding]; other site 926556005307 dimer interface [polypeptide binding]; other site 926556005308 TPP binding site [chemical binding]; other site 926556005309 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 926556005310 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 926556005311 TPP-binding site [chemical binding]; other site 926556005312 dimer interface [polypeptide binding]; other site 926556005313 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 926556005314 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 926556005315 putative valine binding site [chemical binding]; other site 926556005316 dimer interface [polypeptide binding]; other site 926556005317 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 926556005318 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 926556005319 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 926556005320 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 926556005321 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 926556005322 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 926556005323 substrate binding site [chemical binding]; other site 926556005324 ligand binding site [chemical binding]; other site 926556005325 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 926556005326 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 926556005327 substrate binding site [chemical binding]; other site 926556005328 (R)-citramalate synthase; Provisional; Region: PRK09389 926556005329 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 926556005330 active site 926556005331 catalytic residues [active] 926556005332 metal binding site [ion binding]; metal-binding site 926556005333 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 926556005334 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 926556005335 tartrate dehydrogenase; Region: TTC; TIGR02089 926556005336 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926556005337 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926556005338 ligand binding site [chemical binding]; other site 926556005339 flexible hinge region; other site 926556005340 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 926556005341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926556005342 NAD(P) binding site [chemical binding]; other site 926556005343 active site 926556005344 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 926556005345 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 926556005346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926556005347 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 926556005348 NAD(P) binding site [chemical binding]; other site 926556005349 active site 926556005350 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 926556005351 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 926556005352 Walker A/P-loop; other site 926556005353 ATP binding site [chemical binding]; other site 926556005354 Q-loop/lid; other site 926556005355 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 926556005356 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 926556005357 ABC transporter signature motif; other site 926556005358 Walker B; other site 926556005359 D-loop; other site 926556005360 H-loop/switch region; other site 926556005361 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 926556005362 Flavoprotein; Region: Flavoprotein; pfam02441 926556005363 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 926556005364 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 926556005365 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 926556005366 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926556005367 OstA-like protein; Region: OstA_2; pfam13100 926556005368 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 926556005369 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 926556005370 Ligand Binding Site [chemical binding]; other site 926556005371 TilS substrate C-terminal domain; Region: TilS_C; smart00977 926556005372 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926556005373 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926556005374 ligand binding site [chemical binding]; other site 926556005375 flexible hinge region; other site 926556005376 malate dehydrogenase; Reviewed; Region: PRK06223 926556005377 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 926556005378 dimer interface [polypeptide binding]; other site 926556005379 NAD(P) binding site [chemical binding]; other site 926556005380 tetramer (dimer of dimers) interface [polypeptide binding]; other site 926556005381 substrate binding site [chemical binding]; other site 926556005382 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 926556005383 Mechanosensitive ion channel; Region: MS_channel; pfam00924 926556005384 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 926556005385 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 926556005386 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 926556005387 homodimer interface [polypeptide binding]; other site 926556005388 substrate-cofactor binding pocket; other site 926556005389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556005390 catalytic residue [active] 926556005391 Smr domain; Region: Smr; pfam01713 926556005392 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 926556005393 DNA photolyase; Region: DNA_photolyase; pfam00875 926556005394 Family of unknown function (DUF490); Region: DUF490; pfam04357 926556005395 UGMP family protein; Validated; Region: PRK09604 926556005396 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 926556005397 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 926556005398 SmpB-tmRNA interface; other site 926556005399 NlpC/P60 family; Region: NLPC_P60; cl17555 926556005400 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 926556005401 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 926556005402 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 926556005403 active site 926556005404 GntP family permease; Region: GntP_permease; pfam02447 926556005405 fructuronate transporter; Provisional; Region: PRK10034; cl15264 926556005406 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 926556005407 homotrimer interaction site [polypeptide binding]; other site 926556005408 putative active site [active] 926556005409 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme D-Threonine Aldolase; Region: PLPDE_III_D-TA; cd06821 926556005410 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 926556005411 dimer interface [polypeptide binding]; other site 926556005412 active site 926556005413 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926556005414 substrate binding site [chemical binding]; other site 926556005415 catalytic residue [active] 926556005416 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926556005417 active site 926556005418 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 926556005419 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 926556005420 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 926556005421 RNA binding site [nucleotide binding]; other site 926556005422 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 926556005423 RNA binding site [nucleotide binding]; other site 926556005424 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 926556005425 RNA binding site [nucleotide binding]; other site 926556005426 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 926556005427 RNA binding site [nucleotide binding]; other site 926556005428 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 926556005429 RNA binding site [nucleotide binding]; other site 926556005430 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 926556005431 RNA binding site [nucleotide binding]; other site 926556005432 Protein of unknown function DUF72; Region: DUF72; pfam01904 926556005433 Cytochrome c; Region: Cytochrom_C; cl11414 926556005434 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 926556005435 Cytochrome c; Region: Cytochrom_C; pfam00034 926556005436 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 926556005437 heme-binding residues [chemical binding]; other site 926556005438 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 926556005439 molybdopterin cofactor binding site; other site 926556005440 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 926556005441 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 926556005442 4Fe-4S binding domain; Region: Fer4_2; pfam12797 926556005443 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 926556005444 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 926556005445 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 926556005446 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 926556005447 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 926556005448 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 926556005449 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 926556005450 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 926556005451 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 926556005452 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 926556005453 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 926556005454 protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473 926556005455 UbiA prenyltransferase family; Region: UbiA; pfam01040 926556005456 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 926556005457 Subunit I/III interface [polypeptide binding]; other site 926556005458 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 926556005459 Subunit I/III interface [polypeptide binding]; other site 926556005460 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 926556005461 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 926556005462 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 926556005463 Cu(I) binding site [ion binding]; other site 926556005464 Protein of unknown function (DUF420); Region: DUF420; pfam04238 926556005465 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 926556005466 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556005467 dimer interface [polypeptide binding]; other site 926556005468 phosphorylation site [posttranslational modification] 926556005469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556005470 ATP binding site [chemical binding]; other site 926556005471 Mg2+ binding site [ion binding]; other site 926556005472 G-X-G motif; other site 926556005473 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 926556005474 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 926556005475 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 926556005476 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926556005477 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 926556005478 classical (c) SDRs; Region: SDR_c; cd05233 926556005479 NAD(P) binding site [chemical binding]; other site 926556005480 active site 926556005481 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 926556005482 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 926556005483 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 926556005484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 926556005485 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 926556005486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556005487 Walker A/P-loop; other site 926556005488 ATP binding site [chemical binding]; other site 926556005489 Q-loop/lid; other site 926556005490 ABC transporter signature motif; other site 926556005491 Walker B; other site 926556005492 D-loop; other site 926556005493 H-loop/switch region; other site 926556005494 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 926556005495 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 926556005496 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926556005497 active site 926556005498 HIGH motif; other site 926556005499 nucleotide binding site [chemical binding]; other site 926556005500 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926556005501 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 926556005502 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926556005503 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926556005504 active site 926556005505 KMSKS motif; other site 926556005506 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 926556005507 tRNA binding surface [nucleotide binding]; other site 926556005508 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926556005509 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 926556005510 Mechanosensitive ion channel; Region: MS_channel; pfam00924 926556005511 Predicted amidohydrolase [General function prediction only]; Region: COG0388 926556005512 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 926556005513 putative active site [active] 926556005514 catalytic triad [active] 926556005515 putative dimer interface [polypeptide binding]; other site 926556005516 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 926556005517 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926556005518 active site 926556005519 motif I; other site 926556005520 motif II; other site 926556005521 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 926556005522 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 926556005523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 926556005524 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 926556005525 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 926556005526 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 926556005527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 926556005528 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 926556005529 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 926556005530 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 926556005531 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 926556005532 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 926556005533 active site 926556005534 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 926556005535 GTP cyclohydrolase I; Provisional; Region: PLN03044 926556005536 active site 926556005537 Peptide-N-glycosidase F, N terminal; Region: N-glycanase_N; pfam09112 926556005538 Peptide-N-glycosidase F, C terminal; Region: N-glycanase_C; pfam09113 926556005539 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556005540 Sulfatase; Region: Sulfatase; pfam00884 926556005541 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556005542 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556005543 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556005544 DNA binding residues [nucleotide binding] 926556005545 FecR protein; Region: FecR; pfam04773 926556005546 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556005547 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556005548 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556005549 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 926556005550 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556005551 SusD family; Region: SusD; pfam07980 926556005552 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 926556005553 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556005554 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 926556005555 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 926556005556 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 926556005557 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 926556005558 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556005559 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556005560 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556005561 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556005562 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556005563 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556005564 SusD family; Region: SusD; pfam07980 926556005565 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 926556005566 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 926556005567 putative active site [active] 926556005568 putative NTP binding site [chemical binding]; other site 926556005569 putative nucleic acid binding site [nucleotide binding]; other site 926556005570 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 926556005571 conserved repeat domain; Region: B_ant_repeat; TIGR01451 926556005572 Domain of unknown function DUF11; Region: DUF11; cl17728 926556005573 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926556005574 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 926556005575 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 926556005576 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926556005577 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926556005578 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926556005579 ligand binding site [chemical binding]; other site 926556005580 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926556005581 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926556005582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556005583 active site 926556005584 phosphorylation site [posttranslational modification] 926556005585 intermolecular recognition site; other site 926556005586 dimerization interface [polypeptide binding]; other site 926556005587 LytTr DNA-binding domain; Region: LytTR; smart00850 926556005588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556005589 PAS domain; Region: PAS_9; pfam13426 926556005590 putative active site [active] 926556005591 heme pocket [chemical binding]; other site 926556005592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556005593 dimer interface [polypeptide binding]; other site 926556005594 phosphorylation site [posttranslational modification] 926556005595 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 926556005596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556005597 ATP binding site [chemical binding]; other site 926556005598 Mg2+ binding site [ion binding]; other site 926556005599 G-X-G motif; other site 926556005600 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 926556005601 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 926556005602 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 926556005603 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 926556005604 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 926556005605 active site 926556005606 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 926556005607 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926556005608 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556005609 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556005610 DNA binding residues [nucleotide binding] 926556005611 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556005612 FecR protein; Region: FecR; pfam04773 926556005613 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556005614 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556005615 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556005616 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556005617 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556005618 SusD family; Region: SusD; pfam07980 926556005619 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 926556005620 substrate binding site [chemical binding]; other site 926556005621 catalytic residues [active] 926556005622 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 926556005623 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556005624 Sulfatase; Region: Sulfatase; pfam00884 926556005625 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556005626 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556005627 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 926556005628 DNA binding residues [nucleotide binding] 926556005629 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556005630 FecR protein; Region: FecR; pfam04773 926556005631 Secretin and TonB N terminus short domain; Region: STN; pfam07660 926556005632 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556005633 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556005634 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556005635 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556005636 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556005637 SusD family; Region: SusD; pfam07980 926556005638 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556005639 Sulfatase; Region: Sulfatase; cl17466 926556005640 Sulfatase; Region: Sulfatase; cl17466 926556005641 Sulfatase; Region: Sulfatase; cl17466 926556005642 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556005643 Sulfatase; Region: Sulfatase; pfam00884 926556005644 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 926556005645 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556005646 DNA binding residues [nucleotide binding] 926556005647 FecR protein; Region: FecR; pfam04773 926556005648 Secretin and TonB N terminus short domain; Region: STN; pfam07660 926556005649 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556005650 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556005651 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556005652 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556005653 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556005654 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556005655 SusD family; Region: SusD; pfam07980 926556005656 Beta/Gamma crystallin; Region: Crystall; cl02528 926556005657 beta-D-glucuronidase; Provisional; Region: PRK10150 926556005658 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556005659 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 926556005660 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 926556005661 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 926556005662 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 926556005663 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 926556005664 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 926556005665 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 926556005666 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 926556005667 Methyltransferase domain; Region: Methyltransf_23; pfam13489 926556005668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556005669 S-adenosylmethionine binding site [chemical binding]; other site 926556005670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 926556005671 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 926556005672 phosphodiesterase; Provisional; Region: PRK12704 926556005673 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 926556005674 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926556005675 putative DNA binding site [nucleotide binding]; other site 926556005676 putative Zn2+ binding site [ion binding]; other site 926556005677 AsnC family; Region: AsnC_trans_reg; pfam01037 926556005678 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 926556005679 dimer interface [polypeptide binding]; other site 926556005680 active site 926556005681 ADP-ribose binding site [chemical binding]; other site 926556005682 nudix motif; other site 926556005683 metal binding site [ion binding]; metal-binding site 926556005684 multidrug efflux protein; Reviewed; Region: PRK01766 926556005685 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 926556005686 cation binding site [ion binding]; other site 926556005687 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 926556005688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556005689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926556005690 putative substrate translocation pore; other site 926556005691 peptide chain release factor 2; Validated; Region: prfB; PRK00578 926556005692 PCRF domain; Region: PCRF; pfam03462 926556005693 RF-1 domain; Region: RF-1; pfam00472 926556005694 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 926556005695 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 926556005696 homodimer interface [polypeptide binding]; other site 926556005697 substrate-cofactor binding pocket; other site 926556005698 catalytic residue [active] 926556005699 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 926556005700 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926556005701 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926556005702 Walker A/P-loop; other site 926556005703 ATP binding site [chemical binding]; other site 926556005704 Q-loop/lid; other site 926556005705 ABC transporter signature motif; other site 926556005706 Walker B; other site 926556005707 D-loop; other site 926556005708 H-loop/switch region; other site 926556005709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556005710 TPR motif; other site 926556005711 binding surface 926556005712 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 926556005713 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 926556005714 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 926556005715 putative acyl-acceptor binding pocket; other site 926556005716 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 926556005717 heme-binding site [chemical binding]; other site 926556005718 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 926556005719 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 926556005720 dimer interface [polypeptide binding]; other site 926556005721 active site residues [active] 926556005722 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 926556005723 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926556005724 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926556005725 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926556005726 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 926556005727 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926556005728 active site 926556005729 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 926556005730 active site 926556005731 Ap6A binding site [chemical binding]; other site 926556005732 nudix motif; other site 926556005733 metal binding site [ion binding]; metal-binding site 926556005734 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 926556005735 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 926556005736 active site 926556005737 (T/H)XGH motif; other site 926556005738 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 926556005739 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 926556005740 nudix motif; other site 926556005741 AAA domain; Region: AAA_30; pfam13604 926556005742 Family description; Region: UvrD_C_2; pfam13538 926556005743 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 926556005744 Transposase domain (DUF772); Region: DUF772; pfam05598 926556005745 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 926556005746 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 926556005747 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926556005748 ligand binding site [chemical binding]; other site 926556005749 flexible hinge region; other site 926556005750 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 926556005751 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 926556005752 metal binding triad; other site 926556005753 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 926556005754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926556005755 motif II; other site 926556005756 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 926556005757 active site 926556005758 catalytic triad [active] 926556005759 oxyanion hole [active] 926556005760 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 926556005761 dimer interface [polypeptide binding]; other site 926556005762 catalytic triad [active] 926556005763 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 926556005764 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 926556005765 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 926556005766 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 926556005767 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926556005768 catalytic residue [active] 926556005769 GH3 auxin-responsive promoter; Region: GH3; pfam03321 926556005770 LysE type translocator; Region: LysE; pfam01810 926556005771 UDP-glycosyltransferase; Region: PLN02562 926556005772 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 926556005773 putative active site [active] 926556005774 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926556005775 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 926556005776 Walker A/P-loop; other site 926556005777 ATP binding site [chemical binding]; other site 926556005778 ABC transporter; Region: ABC_tran; pfam00005 926556005779 Q-loop/lid; other site 926556005780 ABC transporter signature motif; other site 926556005781 Walker B; other site 926556005782 D-loop; other site 926556005783 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 926556005784 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 926556005785 metal ion-dependent adhesion site (MIDAS); other site 926556005786 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 926556005787 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 926556005788 metal ion-dependent adhesion site (MIDAS); other site 926556005789 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 926556005790 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 926556005791 MutS domain III; Region: MutS_III; pfam05192 926556005792 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556005793 Walker A/P-loop; other site 926556005794 ATP binding site [chemical binding]; other site 926556005795 Q-loop/lid; other site 926556005796 ABC transporter signature motif; other site 926556005797 Walker B; other site 926556005798 D-loop; other site 926556005799 H-loop/switch region; other site 926556005800 Smr domain; Region: Smr; pfam01713 926556005801 homoaconitase; Region: h_aconitase; TIGR00139 926556005802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556005803 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 926556005804 Walker A/P-loop; other site 926556005805 ATP binding site [chemical binding]; other site 926556005806 Q-loop/lid; other site 926556005807 ABC transporter signature motif; other site 926556005808 Walker B; other site 926556005809 D-loop; other site 926556005810 H-loop/switch region; other site 926556005811 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 926556005812 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 926556005813 active site 926556005814 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 926556005815 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 926556005816 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 926556005817 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 926556005818 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 926556005819 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 926556005820 trimer interface [polypeptide binding]; other site 926556005821 active site 926556005822 UDP-GlcNAc binding site [chemical binding]; other site 926556005823 lipid binding site [chemical binding]; lipid-binding site 926556005824 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 926556005825 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926556005826 Zn2+ binding site [ion binding]; other site 926556005827 Mg2+ binding site [ion binding]; other site 926556005828 Response regulator receiver domain; Region: Response_reg; pfam00072 926556005829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556005830 active site 926556005831 phosphorylation site [posttranslational modification] 926556005832 intermolecular recognition site; other site 926556005833 dimerization interface [polypeptide binding]; other site 926556005834 PglZ domain; Region: PglZ; pfam08665 926556005835 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 926556005836 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 926556005837 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 926556005838 hexamer interface [polypeptide binding]; other site 926556005839 ligand binding site [chemical binding]; other site 926556005840 putative active site [active] 926556005841 NAD(P) binding site [chemical binding]; other site 926556005842 Response regulator receiver domain; Region: Response_reg; pfam00072 926556005843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556005844 active site 926556005845 phosphorylation site [posttranslational modification] 926556005846 intermolecular recognition site; other site 926556005847 dimerization interface [polypeptide binding]; other site 926556005848 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 926556005849 ATP binding site [chemical binding]; other site 926556005850 substrate interface [chemical binding]; other site 926556005851 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 926556005852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556005853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556005854 dimer interface [polypeptide binding]; other site 926556005855 phosphorylation site [posttranslational modification] 926556005856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556005857 ATP binding site [chemical binding]; other site 926556005858 Mg2+ binding site [ion binding]; other site 926556005859 G-X-G motif; other site 926556005860 Response regulator receiver domain; Region: Response_reg; pfam00072 926556005861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556005862 active site 926556005863 phosphorylation site [posttranslational modification] 926556005864 intermolecular recognition site; other site 926556005865 dimerization interface [polypeptide binding]; other site 926556005866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556005867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556005868 dimer interface [polypeptide binding]; other site 926556005869 phosphorylation site [posttranslational modification] 926556005870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556005871 ATP binding site [chemical binding]; other site 926556005872 Mg2+ binding site [ion binding]; other site 926556005873 G-X-G motif; other site 926556005874 Uncharacterized conserved protein [Function unknown]; Region: COG2968 926556005875 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 926556005876 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 926556005877 dimer interface [polypeptide binding]; other site 926556005878 substrate binding site [chemical binding]; other site 926556005879 metal binding sites [ion binding]; metal-binding site 926556005880 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 926556005881 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 926556005882 putative acyl-acceptor binding pocket; other site 926556005883 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 926556005884 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 926556005885 active site 926556005886 PHP Thumb interface [polypeptide binding]; other site 926556005887 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 926556005888 generic binding surface II; other site 926556005889 generic binding surface I; other site 926556005890 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 926556005891 BCCT family transporter; Region: BCCT; pfam02028 926556005892 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 926556005893 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 926556005894 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 926556005895 DinB superfamily; Region: DinB_2; pfam12867 926556005896 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556005897 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556005898 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 926556005899 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 926556005900 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 926556005901 active site 926556005902 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 926556005903 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 926556005904 homodimer interface [polypeptide binding]; other site 926556005905 substrate-cofactor binding pocket; other site 926556005906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556005907 catalytic residue [active] 926556005908 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502 926556005909 active site 926556005910 catalytic triad [active] 926556005911 oxyanion hole [active] 926556005912 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 926556005913 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556005914 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556005915 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 926556005916 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 926556005917 putative trimer interface [polypeptide binding]; other site 926556005918 putative CoA binding site [chemical binding]; other site 926556005919 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926556005920 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926556005921 ligand binding site [chemical binding]; other site 926556005922 flexible hinge region; other site 926556005923 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 926556005924 putative switch regulator; other site 926556005925 non-specific DNA interactions [nucleotide binding]; other site 926556005926 DNA binding site [nucleotide binding] 926556005927 sequence specific DNA binding site [nucleotide binding]; other site 926556005928 putative cAMP binding site [chemical binding]; other site 926556005929 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926556005930 Ligand Binding Site [chemical binding]; other site 926556005931 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 926556005932 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 926556005933 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926556005934 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926556005935 active site residue [active] 926556005936 Predicted transporter component [General function prediction only]; Region: COG2391 926556005937 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 926556005938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556005939 putative substrate translocation pore; other site 926556005940 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926556005941 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 926556005942 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 926556005943 active site 926556005944 HIGH motif; other site 926556005945 KMSKS motif; other site 926556005946 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 926556005947 tRNA binding surface [nucleotide binding]; other site 926556005948 anticodon binding site; other site 926556005949 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 926556005950 dimer interface [polypeptide binding]; other site 926556005951 putative tRNA-binding site [nucleotide binding]; other site 926556005952 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 926556005953 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 926556005954 Condensation domain; Region: Condensation; pfam00668 926556005955 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 926556005956 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 926556005957 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 926556005958 acyl-activating enzyme (AAE) consensus motif; other site 926556005959 AMP binding site [chemical binding]; other site 926556005960 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 926556005961 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 926556005962 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 926556005963 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 926556005964 acyl-activating enzyme (AAE) consensus motif; other site 926556005965 AMP binding site [chemical binding]; other site 926556005966 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 926556005967 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 926556005968 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 926556005969 active site 926556005970 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 926556005971 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 926556005972 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 926556005973 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 926556005974 inhibitor-cofactor binding pocket; inhibition site 926556005975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556005976 catalytic residue [active] 926556005977 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 926556005978 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 926556005979 Walker A/P-loop; other site 926556005980 ATP binding site [chemical binding]; other site 926556005981 Q-loop/lid; other site 926556005982 ABC transporter signature motif; other site 926556005983 Walker B; other site 926556005984 D-loop; other site 926556005985 H-loop/switch region; other site 926556005986 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 926556005987 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926556005988 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 926556005989 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 926556005990 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 926556005991 Surface antigen; Region: Bac_surface_Ag; pfam01103 926556005992 Haemolytic domain; Region: Haemolytic; pfam01809 926556005993 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 926556005994 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 926556005995 NAD+ synthase (glutamine-hydrolysing); Region: PLN02339 926556005996 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 926556005997 multimer interface [polypeptide binding]; other site 926556005998 active site 926556005999 catalytic triad [active] 926556006000 protein interface 1 [polypeptide binding]; other site 926556006001 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 926556006002 Ligand Binding Site [chemical binding]; other site 926556006003 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 926556006004 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 926556006005 dimerization interface [polypeptide binding]; other site 926556006006 active site 926556006007 metal binding site [ion binding]; metal-binding site 926556006008 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 926556006009 dsRNA binding site [nucleotide binding]; other site 926556006010 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 926556006011 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 926556006012 dimer interface [polypeptide binding]; other site 926556006013 active site 926556006014 acyl carrier protein; Provisional; Region: acpP; PRK00982 926556006015 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 926556006016 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 926556006017 domain interfaces; other site 926556006018 active site 926556006019 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 926556006020 Domain of unknown function (DUF814); Region: DUF814; pfam05670 926556006021 putative hydrolase; Provisional; Region: PRK02113 926556006022 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 926556006023 Response regulator receiver domain; Region: Response_reg; pfam00072 926556006024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556006025 active site 926556006026 phosphorylation site [posttranslational modification] 926556006027 intermolecular recognition site; other site 926556006028 dimerization interface [polypeptide binding]; other site 926556006029 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926556006030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556006031 active site 926556006032 phosphorylation site [posttranslational modification] 926556006033 intermolecular recognition site; other site 926556006034 dimerization interface [polypeptide binding]; other site 926556006035 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 926556006036 putative binding surface; other site 926556006037 active site 926556006038 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 926556006039 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 926556006040 6-phosphofructokinase; Provisional; Region: PRK03202 926556006041 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 926556006042 active site 926556006043 ADP/pyrophosphate binding site [chemical binding]; other site 926556006044 dimerization interface [polypeptide binding]; other site 926556006045 allosteric effector site; other site 926556006046 fructose-1,6-bisphosphate binding site; other site 926556006047 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926556006048 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 926556006049 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926556006050 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 926556006051 putative NAD(P) binding site [chemical binding]; other site 926556006052 active site 926556006053 putative substrate binding site [chemical binding]; other site 926556006054 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 926556006055 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 926556006056 NAD binding site [chemical binding]; other site 926556006057 substrate binding site [chemical binding]; other site 926556006058 homodimer interface [polypeptide binding]; other site 926556006059 active site 926556006060 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 926556006061 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 926556006062 AAA domain; Region: AAA_31; pfam13614 926556006063 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 926556006064 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 926556006065 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 926556006066 YceI-like domain; Region: YceI; pfam04264 926556006067 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 926556006068 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 926556006069 trimer interface [polypeptide binding]; other site 926556006070 putative metal binding site [ion binding]; other site 926556006071 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 926556006072 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926556006073 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 926556006074 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 926556006075 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 926556006076 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 926556006077 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 926556006078 AMP binding site [chemical binding]; other site 926556006079 active site 926556006080 acyl-activating enzyme (AAE) consensus motif; other site 926556006081 CoA binding site [chemical binding]; other site 926556006082 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 926556006083 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 926556006084 substrate binding site [chemical binding]; other site 926556006085 oxyanion hole (OAH) forming residues; other site 926556006086 trimer interface [polypeptide binding]; other site 926556006087 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 926556006088 Beta-lactamase; Region: Beta-lactamase; pfam00144 926556006089 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 926556006090 putative active site [active] 926556006091 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 926556006092 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 926556006093 dimer interface [polypeptide binding]; other site 926556006094 tetramer interface [polypeptide binding]; other site 926556006095 PYR/PP interface [polypeptide binding]; other site 926556006096 TPP binding site [chemical binding]; other site 926556006097 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 926556006098 TPP-binding site [chemical binding]; other site 926556006099 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 926556006100 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 926556006101 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 926556006102 CoenzymeA binding site [chemical binding]; other site 926556006103 subunit interaction site [polypeptide binding]; other site 926556006104 PHB binding site; other site 926556006105 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 926556006106 catalytic core [active] 926556006107 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 926556006108 Putative zinc ribbon domain; Region: DUF164; pfam02591 926556006109 Uncharacterized conserved protein [Function unknown]; Region: COG0327 926556006110 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 926556006111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 926556006112 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 926556006113 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 926556006114 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 926556006115 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 926556006116 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 926556006117 active site 926556006118 dinuclear metal binding site [ion binding]; other site 926556006119 dimerization interface [polypeptide binding]; other site 926556006120 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926556006121 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 926556006122 FtsX-like permease family; Region: FtsX; pfam02687 926556006123 Protein of unknown function (DUF805); Region: DUF805; pfam05656 926556006124 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 926556006125 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 926556006126 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926556006127 FeS/SAM binding site; other site 926556006128 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 926556006129 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 926556006130 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 926556006131 Creatinine amidohydrolase; Region: Creatininase; pfam02633 926556006132 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 926556006133 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 926556006134 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 926556006135 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 926556006136 substrate binding site; other site 926556006137 tetramer interface; other site 926556006138 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 926556006139 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926556006140 putative metal binding site [ion binding]; other site 926556006141 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 926556006142 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 926556006143 oligomer interface [polypeptide binding]; other site 926556006144 metal binding site [ion binding]; metal-binding site 926556006145 metal binding site [ion binding]; metal-binding site 926556006146 Cl binding site [ion binding]; other site 926556006147 aspartate ring; other site 926556006148 basic sphincter; other site 926556006149 putative hydrophobic gate; other site 926556006150 periplasmic entrance; other site 926556006151 Response regulator receiver domain; Region: Response_reg; pfam00072 926556006152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556006153 active site 926556006154 phosphorylation site [posttranslational modification] 926556006155 intermolecular recognition site; other site 926556006156 dimerization interface [polypeptide binding]; other site 926556006157 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 926556006158 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 926556006159 ring oligomerisation interface [polypeptide binding]; other site 926556006160 ATP/Mg binding site [chemical binding]; other site 926556006161 stacking interactions; other site 926556006162 hinge regions; other site 926556006163 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 926556006164 oligomerisation interface [polypeptide binding]; other site 926556006165 mobile loop; other site 926556006166 roof hairpin; other site 926556006167 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 926556006168 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 926556006169 Preprotein translocase SecG subunit; Region: SecG; pfam03840 926556006170 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 926556006171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556006172 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 926556006173 Walker A motif; other site 926556006174 ATP binding site [chemical binding]; other site 926556006175 Walker B motif; other site 926556006176 arginine finger; other site 926556006177 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 926556006178 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 926556006179 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 926556006180 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926556006181 FeS/SAM binding site; other site 926556006182 TRAM domain; Region: TRAM; pfam01938 926556006183 Family of unknown function (DUF490); Region: DUF490; pfam04357 926556006184 Surface antigen; Region: Bac_surface_Ag; pfam01103 926556006185 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cd00363 926556006186 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 926556006187 active site 926556006188 ADP/pyrophosphate binding site [chemical binding]; other site 926556006189 dimerization interface [polypeptide binding]; other site 926556006190 allosteric effector site; other site 926556006191 fructose-1,6-bisphosphate binding site; other site 926556006192 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 926556006193 active site 926556006194 dimer interfaces [polypeptide binding]; other site 926556006195 catalytic residues [active] 926556006196 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926556006197 primosomal protein N' Region: priA; TIGR00595 926556006198 ATP binding site [chemical binding]; other site 926556006199 putative Mg++ binding site [ion binding]; other site 926556006200 helicase superfamily c-terminal domain; Region: HELICc; smart00490 926556006201 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 926556006202 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 926556006203 catalytic residues [active] 926556006204 GSCFA family; Region: GSCFA; pfam08885 926556006205 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 926556006206 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 926556006207 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 926556006208 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 926556006209 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 926556006210 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 926556006211 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 926556006212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556006213 S-adenosylmethionine binding site [chemical binding]; other site 926556006214 Methyltransferase domain; Region: Methyltransf_24; pfam13578 926556006215 S-adenosylmethionine binding site [chemical binding]; other site 926556006216 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 926556006217 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 926556006218 ligand binding site [chemical binding]; other site 926556006219 active site 926556006220 UGI interface [polypeptide binding]; other site 926556006221 catalytic site [active] 926556006222 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 926556006223 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 926556006224 Catalytic site [active] 926556006225 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 926556006226 dihydrodipicolinate reductase; Provisional; Region: PRK00048 926556006227 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 926556006228 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 926556006229 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 926556006230 ParB-like nuclease domain; Region: ParBc; pfam02195 926556006231 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 926556006232 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 926556006233 P-loop; other site 926556006234 Magnesium ion binding site [ion binding]; other site 926556006235 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 926556006236 Magnesium ion binding site [ion binding]; other site 926556006237 membrane protein insertase; Provisional; Region: PRK01318 926556006238 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 926556006239 CTP synthetase; Validated; Region: pyrG; PRK05380 926556006240 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 926556006241 Catalytic site [active] 926556006242 active site 926556006243 UTP binding site [chemical binding]; other site 926556006244 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 926556006245 active site 926556006246 putative oxyanion hole; other site 926556006247 catalytic triad [active] 926556006248 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 926556006249 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 926556006250 active site 926556006251 NTP binding site [chemical binding]; other site 926556006252 metal binding triad [ion binding]; metal-binding site 926556006253 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 926556006254 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926556006255 Zn2+ binding site [ion binding]; other site 926556006256 Mg2+ binding site [ion binding]; other site 926556006257 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 926556006258 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 926556006259 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 926556006260 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 926556006261 Catalytic dyad [active] 926556006262 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 926556006263 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 926556006264 Mg++ binding site [ion binding]; other site 926556006265 putative catalytic motif [active] 926556006266 substrate binding site [chemical binding]; other site 926556006267 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 926556006268 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 926556006269 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 926556006270 active site 926556006271 DNA binding site [nucleotide binding] 926556006272 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 926556006273 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 926556006274 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926556006275 Coenzyme A binding pocket [chemical binding]; other site 926556006276 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 926556006277 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 926556006278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926556006279 Coenzyme A binding pocket [chemical binding]; other site 926556006280 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 926556006281 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 926556006282 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 926556006283 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 926556006284 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 926556006285 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 926556006286 active site 926556006287 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 926556006288 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 926556006289 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 926556006290 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 926556006291 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556006292 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556006293 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556006294 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556006295 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556006296 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556006297 SusD family; Region: SusD; pfam07980 926556006298 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 926556006299 RNA/DNA hybrid binding site [nucleotide binding]; other site 926556006300 active site 926556006301 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 926556006302 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926556006303 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 926556006304 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 926556006305 putative active site [active] 926556006306 putative metal binding site [ion binding]; other site 926556006307 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556006308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556006309 ATP binding site [chemical binding]; other site 926556006310 Mg2+ binding site [ion binding]; other site 926556006311 G-X-G motif; other site 926556006312 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 926556006313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556006314 active site 926556006315 phosphorylation site [posttranslational modification] 926556006316 intermolecular recognition site; other site 926556006317 dimerization interface [polypeptide binding]; other site 926556006318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556006319 Walker A motif; other site 926556006320 ATP binding site [chemical binding]; other site 926556006321 Walker B motif; other site 926556006322 arginine finger; other site 926556006323 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 926556006324 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 926556006325 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 926556006326 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 926556006327 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 926556006328 putative active site [active] 926556006329 putative metal binding site [ion binding]; other site 926556006330 FtsH Extracellular; Region: FtsH_ext; pfam06480 926556006331 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 926556006332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556006333 Walker A motif; other site 926556006334 ATP binding site [chemical binding]; other site 926556006335 Walker B motif; other site 926556006336 arginine finger; other site 926556006337 Peptidase family M41; Region: Peptidase_M41; pfam01434 926556006338 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 926556006339 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 926556006340 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 926556006341 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 926556006342 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 926556006343 homotetramer interface [polypeptide binding]; other site 926556006344 ligand binding site [chemical binding]; other site 926556006345 catalytic site [active] 926556006346 NAD binding site [chemical binding]; other site 926556006347 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 926556006348 NAD(P) binding site [chemical binding]; other site 926556006349 short chain dehydrogenase; Provisional; Region: PRK07677 926556006350 substrate binding site [chemical binding]; other site 926556006351 homotetramer interface [polypeptide binding]; other site 926556006352 active site 926556006353 homodimer interface [polypeptide binding]; other site 926556006354 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 926556006355 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 926556006356 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 926556006357 Outer membrane efflux protein; Region: OEP; pfam02321 926556006358 Outer membrane efflux protein; Region: OEP; pfam02321 926556006359 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926556006360 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926556006361 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556006362 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 926556006363 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 926556006364 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 926556006365 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926556006366 Soluble P-type ATPase [General function prediction only]; Region: COG4087 926556006367 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 926556006368 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 926556006369 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 926556006370 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 926556006371 B12 binding site [chemical binding]; other site 926556006372 cobalt ligand [ion binding]; other site 926556006373 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 926556006374 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 926556006375 OsmC-like protein; Region: OsmC; pfam02566 926556006376 Cache domain; Region: Cache_1; pfam02743 926556006377 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556006378 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 926556006379 putative active site [active] 926556006380 heme pocket [chemical binding]; other site 926556006381 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 926556006382 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556006383 putative active site [active] 926556006384 heme pocket [chemical binding]; other site 926556006385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556006386 dimer interface [polypeptide binding]; other site 926556006387 phosphorylation site [posttranslational modification] 926556006388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556006389 ATP binding site [chemical binding]; other site 926556006390 Mg2+ binding site [ion binding]; other site 926556006391 G-X-G motif; other site 926556006392 Response regulator receiver domain; Region: Response_reg; pfam00072 926556006393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556006394 active site 926556006395 phosphorylation site [posttranslational modification] 926556006396 intermolecular recognition site; other site 926556006397 dimerization interface [polypeptide binding]; other site 926556006398 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 926556006399 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 926556006400 E3 interaction surface; other site 926556006401 lipoyl attachment site [posttranslational modification]; other site 926556006402 e3 binding domain; Region: E3_binding; pfam02817 926556006403 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 926556006404 competence damage-inducible protein A; Provisional; Region: PRK00549 926556006405 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 926556006406 putative MPT binding site; other site 926556006407 Competence-damaged protein; Region: CinA; pfam02464 926556006408 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 926556006409 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 926556006410 folate binding site [chemical binding]; other site 926556006411 NADP+ binding site [chemical binding]; other site 926556006412 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 926556006413 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 926556006414 putative active site [active] 926556006415 substrate binding site [chemical binding]; other site 926556006416 putative cosubstrate binding site; other site 926556006417 catalytic site [active] 926556006418 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 926556006419 substrate binding site [chemical binding]; other site 926556006420 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 926556006421 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 926556006422 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926556006423 FtsX-like permease family; Region: FtsX; pfam02687 926556006424 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 926556006425 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 926556006426 Ligand binding site; other site 926556006427 Putative Catalytic site; other site 926556006428 DXD motif; other site 926556006429 TPR repeat; Region: TPR_11; pfam13414 926556006430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556006431 binding surface 926556006432 TPR motif; other site 926556006433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556006434 binding surface 926556006435 TPR motif; other site 926556006436 TPR repeat; Region: TPR_11; pfam13414 926556006437 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 926556006438 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926556006439 active site 926556006440 motif I; other site 926556006441 motif II; other site 926556006442 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 926556006443 putative active site pocket [active] 926556006444 4-fold oligomerization interface [polypeptide binding]; other site 926556006445 metal binding residues [ion binding]; metal-binding site 926556006446 3-fold/trimer interface [polypeptide binding]; other site 926556006447 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 926556006448 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926556006449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556006450 homodimer interface [polypeptide binding]; other site 926556006451 catalytic residue [active] 926556006452 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 926556006453 histidinol dehydrogenase; Region: hisD; TIGR00069 926556006454 NAD binding site [chemical binding]; other site 926556006455 dimerization interface [polypeptide binding]; other site 926556006456 product binding site; other site 926556006457 substrate binding site [chemical binding]; other site 926556006458 zinc binding site [ion binding]; other site 926556006459 catalytic residues [active] 926556006460 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 926556006461 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 926556006462 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 926556006463 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 926556006464 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 926556006465 tRNA; other site 926556006466 putative tRNA binding site [nucleotide binding]; other site 926556006467 putative NADP binding site [chemical binding]; other site 926556006468 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 926556006469 putative rRNA binding site [nucleotide binding]; other site 926556006470 universal stress protein UspE; Provisional; Region: PRK11175 926556006471 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926556006472 Ligand Binding Site [chemical binding]; other site 926556006473 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926556006474 Ligand Binding Site [chemical binding]; other site 926556006475 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 926556006476 UbiA prenyltransferase family; Region: UbiA; pfam01040 926556006477 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 926556006478 catalytic residues [active] 926556006479 dimer interface [polypeptide binding]; other site 926556006480 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 926556006481 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 926556006482 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926556006483 active site 926556006484 HIGH motif; other site 926556006485 nucleotide binding site [chemical binding]; other site 926556006486 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 926556006487 KMSK motif region; other site 926556006488 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 926556006489 tRNA binding surface [nucleotide binding]; other site 926556006490 anticodon binding site; other site 926556006491 Arginase family; Region: Arginase; cd09989 926556006492 active site 926556006493 Mn binding site [ion binding]; other site 926556006494 oligomer interface [polypeptide binding]; other site 926556006495 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 926556006496 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 926556006497 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926556006498 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926556006499 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556006500 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 926556006501 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 926556006502 dimer interface [polypeptide binding]; other site 926556006503 active site 926556006504 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926556006505 catalytic residues [active] 926556006506 substrate binding site [chemical binding]; other site 926556006507 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 926556006508 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 926556006509 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926556006510 catalytic residue [active] 926556006511 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926556006512 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 926556006513 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 926556006514 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 926556006515 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926556006516 active site 926556006517 HIGH motif; other site 926556006518 nucleotide binding site [chemical binding]; other site 926556006519 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 926556006520 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 926556006521 active site 926556006522 KMSKS motif; other site 926556006523 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 926556006524 tRNA binding surface [nucleotide binding]; other site 926556006525 anticodon binding site; other site 926556006526 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 926556006527 fumarylacetoacetase; Region: PLN02856 926556006528 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 926556006529 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 926556006530 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 926556006531 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 926556006532 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926556006533 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 926556006534 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556006535 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556006536 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 926556006537 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 926556006538 Fatty acid desaturase; Region: FA_desaturase; pfam00487 926556006539 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 926556006540 putative di-iron ligands [ion binding]; other site 926556006541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 926556006542 Putative glucoamylase; Region: Glycoamylase; pfam10091 926556006543 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 926556006544 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926556006545 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 926556006546 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 926556006547 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 926556006548 Bacterial Ig-like domain; Region: Big_5; pfam13205 926556006549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 926556006550 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 926556006551 Putative glucoamylase; Region: Glycoamylase; pfam10091 926556006552 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926556006553 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556006554 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556006555 SusD family; Region: SusD; pfam07980 926556006556 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556006557 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556006558 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556006559 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 926556006560 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 926556006561 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 926556006562 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 926556006563 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 926556006564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556006565 Walker A/P-loop; other site 926556006566 ATP binding site [chemical binding]; other site 926556006567 Q-loop/lid; other site 926556006568 ABC transporter signature motif; other site 926556006569 Walker B; other site 926556006570 D-loop; other site 926556006571 H-loop/switch region; other site 926556006572 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 926556006573 active site 926556006574 intersubunit interactions; other site 926556006575 catalytic residue [active] 926556006576 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 926556006577 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 926556006578 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 926556006579 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 926556006580 four helix bundle protein; Region: TIGR02436 926556006581 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 926556006582 Glutamine amidotransferase class-I; Region: GATase; pfam00117 926556006583 glutamine binding [chemical binding]; other site 926556006584 catalytic triad [active] 926556006585 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 926556006586 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 926556006587 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 926556006588 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 926556006589 active site 926556006590 ribulose/triose binding site [chemical binding]; other site 926556006591 phosphate binding site [ion binding]; other site 926556006592 substrate (anthranilate) binding pocket [chemical binding]; other site 926556006593 product (indole) binding pocket [chemical binding]; other site 926556006594 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 926556006595 active site 926556006596 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 926556006597 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 926556006598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556006599 catalytic residue [active] 926556006600 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 926556006601 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 926556006602 substrate binding site [chemical binding]; other site 926556006603 active site 926556006604 catalytic residues [active] 926556006605 heterodimer interface [polypeptide binding]; other site 926556006606 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 926556006607 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 926556006608 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 926556006609 cofactor binding site; other site 926556006610 metal binding site [ion binding]; metal-binding site 926556006611 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 926556006612 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 926556006613 putative active site [active] 926556006614 oxyanion strand; other site 926556006615 catalytic triad [active] 926556006616 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 926556006617 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 926556006618 catalytic residues [active] 926556006619 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 926556006620 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 926556006621 substrate binding site [chemical binding]; other site 926556006622 glutamase interaction surface [polypeptide binding]; other site 926556006623 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 926556006624 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 926556006625 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 926556006626 metal binding site [ion binding]; metal-binding site 926556006627 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 926556006628 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 926556006629 Catalytic dyad [active] 926556006630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926556006631 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 926556006632 ABC1 family; Region: ABC1; cl17513 926556006633 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 926556006634 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 926556006635 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926556006636 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926556006637 ABC transporter; Region: ABC_tran_2; pfam12848 926556006638 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926556006639 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 926556006640 GTP-binding protein YchF; Reviewed; Region: PRK09601 926556006641 YchF GTPase; Region: YchF; cd01900 926556006642 G1 box; other site 926556006643 GTP/Mg2+ binding site [chemical binding]; other site 926556006644 Switch I region; other site 926556006645 G2 box; other site 926556006646 Switch II region; other site 926556006647 G3 box; other site 926556006648 G4 box; other site 926556006649 G5 box; other site 926556006650 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 926556006651 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 926556006652 Domain of unknown function DUF20; Region: UPF0118; pfam01594 926556006653 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 926556006654 putative oxidoreductase; Provisional; Region: PRK13984 926556006655 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 926556006656 NAD(P) binding site [chemical binding]; other site 926556006657 catalytic residues [active] 926556006658 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 926556006659 aconitate hydratase; Validated; Region: PRK07229 926556006660 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584 926556006661 substrate binding site [chemical binding]; other site 926556006662 ligand binding site [chemical binding]; other site 926556006663 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 926556006664 substrate binding site [chemical binding]; other site 926556006665 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 926556006666 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556006667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556006668 dimer interface [polypeptide binding]; other site 926556006669 phosphorylation site [posttranslational modification] 926556006670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556006671 ATP binding site [chemical binding]; other site 926556006672 Mg2+ binding site [ion binding]; other site 926556006673 G-X-G motif; other site 926556006674 Response regulator receiver domain; Region: Response_reg; pfam00072 926556006675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556006676 active site 926556006677 phosphorylation site [posttranslational modification] 926556006678 intermolecular recognition site; other site 926556006679 dimerization interface [polypeptide binding]; other site 926556006680 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556006681 TPR repeat; Region: TPR_11; pfam13414 926556006682 binding surface 926556006683 TPR motif; other site 926556006684 TPR repeat; Region: TPR_11; pfam13414 926556006685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556006686 TPR repeat; Region: TPR_11; pfam13414 926556006687 binding surface 926556006688 TPR motif; other site 926556006689 TPR repeat; Region: TPR_11; pfam13414 926556006690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556006691 binding surface 926556006692 TPR motif; other site 926556006693 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 926556006694 ArsC family; Region: ArsC; pfam03960 926556006695 catalytic residues [active] 926556006696 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 926556006697 Cation efflux family; Region: Cation_efflux; pfam01545 926556006698 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 926556006699 dimer interface [polypeptide binding]; other site 926556006700 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926556006701 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 926556006702 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 926556006703 conserved cys residue [active] 926556006704 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556006705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556006706 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556006707 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556006708 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926556006709 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 926556006710 Predicted transcriptional regulators [Transcription]; Region: COG1733 926556006711 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 926556006712 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 926556006713 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 926556006714 Int/Topo IB signature motif; other site 926556006715 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926556006716 active site 926556006717 DNA binding site [nucleotide binding] 926556006718 Int/Topo IB signature motif; other site 926556006719 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 926556006720 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926556006721 active site 926556006722 DNA binding site [nucleotide binding] 926556006723 Int/Topo IB signature motif; other site 926556006724 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 926556006725 Active site serine [active] 926556006726 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926556006727 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926556006728 active site 926556006729 catalytic tetrad [active] 926556006730 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 926556006731 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 926556006732 THF binding site; other site 926556006733 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 926556006734 substrate binding site [chemical binding]; other site 926556006735 THF binding site; other site 926556006736 zinc-binding site [ion binding]; other site 926556006737 PAS domain; Region: PAS_9; pfam13426 926556006738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556006739 putative active site [active] 926556006740 heme pocket [chemical binding]; other site 926556006741 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 926556006742 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 926556006743 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 926556006744 active site 926556006745 catalytic site [active] 926556006746 substrate binding site [chemical binding]; other site 926556006747 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 926556006748 GIY-YIG motif/motif A; other site 926556006749 active site 926556006750 catalytic site [active] 926556006751 putative DNA binding site [nucleotide binding]; other site 926556006752 metal binding site [ion binding]; metal-binding site 926556006753 DinB superfamily; Region: DinB_2; pfam12867 926556006754 biotin synthase; Region: bioB; TIGR00433 926556006755 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926556006756 FeS/SAM binding site; other site 926556006757 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 926556006758 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 926556006759 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 926556006760 acyl-activating enzyme (AAE) consensus motif; other site 926556006761 putative AMP binding site [chemical binding]; other site 926556006762 putative active site [active] 926556006763 putative CoA binding site [chemical binding]; other site 926556006764 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 926556006765 active site 926556006766 DinB superfamily; Region: DinB_2; pfam12867 926556006767 metal-dependent hydrolase; Provisional; Region: PRK13291 926556006768 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 926556006769 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 926556006770 Peptidase family M28; Region: Peptidase_M28; pfam04389 926556006771 putative metal binding site [ion binding]; other site 926556006772 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926556006773 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 926556006774 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 926556006775 active site 926556006776 Zn binding site [ion binding]; other site 926556006777 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 926556006778 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 926556006779 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556006780 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 926556006781 Surface antigen; Region: Bac_surface_Ag; pfam01103 926556006782 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 926556006783 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 926556006784 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 926556006785 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 926556006786 Rdx family; Region: Rdx; cl01407 926556006787 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556006788 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556006789 FecR protein; Region: FecR; pfam04773 926556006790 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556006791 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556006792 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556006793 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556006794 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 926556006795 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 926556006796 active site 926556006797 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 926556006798 putative catalytic site [active] 926556006799 putative metal binding site [ion binding]; other site 926556006800 putative phosphate binding site [ion binding]; other site 926556006801 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556006802 Sulfatase; Region: Sulfatase; pfam00884 926556006803 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926556006804 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 926556006805 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 926556006806 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 926556006807 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 926556006808 Walker A/P-loop; other site 926556006809 ATP binding site [chemical binding]; other site 926556006810 Q-loop/lid; other site 926556006811 ABC transporter signature motif; other site 926556006812 Walker B; other site 926556006813 D-loop; other site 926556006814 H-loop/switch region; other site 926556006815 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 926556006816 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 926556006817 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 926556006818 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926556006819 active site 926556006820 Methyltransferase domain; Region: Methyltransf_24; pfam13578 926556006821 Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316 926556006822 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926556006823 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926556006824 active site 926556006825 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 926556006826 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926556006827 active site 926556006828 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 926556006829 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926556006830 active site 926556006831 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556006832 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926556006833 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 926556006834 putative active site [active] 926556006835 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556006836 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926556006837 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556006838 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926556006839 Transposase IS200 like; Region: Y1_Tnp; pfam01797 926556006840 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u5; cd10929 926556006841 putative active site [active] 926556006842 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 926556006843 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926556006844 substrate binding pocket [chemical binding]; other site 926556006845 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556006846 Sulfatase; Region: Sulfatase; pfam00884 926556006847 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926556006848 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556006849 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556006850 SusD family; Region: SusD; pfam07980 926556006851 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556006852 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556006853 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556006854 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556006855 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556006856 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 926556006857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926556006858 Coenzyme A binding pocket [chemical binding]; other site 926556006859 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 926556006860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926556006861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926556006862 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926556006863 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556006864 catalytic residues [active] 926556006865 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 926556006866 Amidohydrolase; Region: Amidohydro_2; pfam04909 926556006867 active site 926556006868 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926556006869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556006870 active site 926556006871 phosphorylation site [posttranslational modification] 926556006872 intermolecular recognition site; other site 926556006873 dimerization interface [polypeptide binding]; other site 926556006874 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926556006875 DNA binding site [nucleotide binding] 926556006876 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556006877 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926556006878 dimerization interface [polypeptide binding]; other site 926556006879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556006880 dimer interface [polypeptide binding]; other site 926556006881 phosphorylation site [posttranslational modification] 926556006882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556006883 ATP binding site [chemical binding]; other site 926556006884 Mg2+ binding site [ion binding]; other site 926556006885 G-X-G motif; other site 926556006886 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 926556006887 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 926556006888 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 926556006889 TrkA-C domain; Region: TrkA_C; pfam02080 926556006890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556006891 S-adenosylmethionine binding site [chemical binding]; other site 926556006892 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 926556006893 putative active site [active] 926556006894 catalytic site [active] 926556006895 Alkaline phosphatase homologues; Region: alkPPc; smart00098 926556006896 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 926556006897 active site 926556006898 dimer interface [polypeptide binding]; other site 926556006899 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 926556006900 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 926556006901 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 926556006902 putative catalytic cysteine [active] 926556006903 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 926556006904 nucleotide binding site [chemical binding]; other site 926556006905 homotetrameric interface [polypeptide binding]; other site 926556006906 putative phosphate binding site [ion binding]; other site 926556006907 putative allosteric binding site; other site 926556006908 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 926556006909 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 926556006910 Autotransporter beta-domain; Region: Autotransporter; cl17461 926556006911 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 926556006912 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 926556006913 active site 926556006914 nucleophile elbow; other site 926556006915 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 926556006916 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 926556006917 active site 926556006918 Peptidase family M50; Region: Peptidase_M50; pfam02163 926556006919 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 926556006920 putative substrate binding region [chemical binding]; other site 926556006921 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 926556006922 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926556006923 motif II; other site 926556006924 Helix-turn-helix domain; Region: HTH_17; pfam12728 926556006925 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556006926 non-specific DNA binding site [nucleotide binding]; other site 926556006927 salt bridge; other site 926556006928 sequence-specific DNA binding site [nucleotide binding]; other site 926556006929 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556006930 non-specific DNA binding site [nucleotide binding]; other site 926556006931 sequence-specific DNA binding site [nucleotide binding]; other site 926556006932 salt bridge; other site 926556006933 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 926556006934 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556006935 non-specific DNA binding site [nucleotide binding]; other site 926556006936 salt bridge; other site 926556006937 sequence-specific DNA binding site [nucleotide binding]; other site 926556006938 UPF0489 domain; Region: UPF0489; pfam12640 926556006939 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 926556006940 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 926556006941 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926556006942 active site 926556006943 DNA binding site [nucleotide binding] 926556006944 Int/Topo IB signature motif; other site 926556006945 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926556006946 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556006947 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556006948 DNA binding residues [nucleotide binding] 926556006949 FecR protein; Region: FecR; pfam04773 926556006950 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556006951 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556006952 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556006953 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556006954 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556006955 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556006956 SusD family; Region: SusD; pfam07980 926556006957 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556006958 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556006959 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556006960 SusD family; Region: SusD; pfam07980 926556006961 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 926556006962 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 926556006963 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 926556006964 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 926556006965 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 926556006966 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 926556006967 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 926556006968 active site 926556006969 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 926556006970 substrate binding site [chemical binding]; other site 926556006971 active site 926556006972 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 926556006973 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 926556006974 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 926556006975 substrate binding site [chemical binding]; other site 926556006976 active site 926556006977 Domain of unknown function (DUF303); Region: DUF303; pfam03629 926556006978 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 926556006979 Putative esterase; Region: Esterase; pfam00756 926556006980 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 926556006981 Putative esterase; Region: Esterase; pfam00756 926556006982 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 926556006983 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 926556006984 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 926556006985 substrate binding site [chemical binding]; other site 926556006986 active site 926556006987 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 926556006988 metal binding site [ion binding]; metal-binding site 926556006989 ligand binding site [chemical binding]; other site 926556006990 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 926556006991 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 926556006992 inhibitor binding site; inhibition site 926556006993 active site 926556006994 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 926556006995 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 926556006996 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 926556006997 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 926556006998 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 926556006999 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 926556007000 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 926556007001 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 926556007002 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 926556007003 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 926556007004 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 926556007005 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 926556007006 substrate binding site [chemical binding]; other site 926556007007 active site 926556007008 Domain of unknown function (DUF303); Region: DUF303; pfam03629 926556007009 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556007010 Domain of unknown function (DUF303); Region: DUF303; pfam03629 926556007011 RibD C-terminal domain; Region: RibD_C; cl17279 926556007012 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 926556007013 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 926556007014 active site 926556007015 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 926556007016 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 926556007017 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 926556007018 Kelch motif; Region: Kelch_1; pfam01344 926556007019 Kelch motif; Region: Kelch_1; pfam01344 926556007020 Histidine kinase; Region: His_kinase; pfam06580 926556007021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556007022 Response regulator receiver domain; Region: Response_reg; pfam00072 926556007023 active site 926556007024 phosphorylation site [posttranslational modification] 926556007025 intermolecular recognition site; other site 926556007026 dimerization interface [polypeptide binding]; other site 926556007027 LytTr DNA-binding domain; Region: LytTR; smart00850 926556007028 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 926556007029 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 926556007030 dimer interface [polypeptide binding]; other site 926556007031 active site 926556007032 heme binding site [chemical binding]; other site 926556007033 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 926556007034 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 926556007035 active site 926556007036 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556007037 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 926556007038 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 926556007039 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 926556007040 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556007041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556007042 dimer interface [polypeptide binding]; other site 926556007043 phosphorylation site [posttranslational modification] 926556007044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556007045 ATP binding site [chemical binding]; other site 926556007046 Mg2+ binding site [ion binding]; other site 926556007047 G-X-G motif; other site 926556007048 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556007049 PAS domain; Region: PAS_9; pfam13426 926556007050 putative active site [active] 926556007051 heme pocket [chemical binding]; other site 926556007052 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926556007053 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 926556007054 PAS domain S-box; Region: sensory_box; TIGR00229 926556007055 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556007056 putative active site [active] 926556007057 heme pocket [chemical binding]; other site 926556007058 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926556007059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556007060 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 926556007061 putative active site [active] 926556007062 heme pocket [chemical binding]; other site 926556007063 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556007064 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 926556007065 putative active site [active] 926556007066 heme pocket [chemical binding]; other site 926556007067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556007068 putative active site [active] 926556007069 heme pocket [chemical binding]; other site 926556007070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556007071 phosphorylation site [posttranslational modification] 926556007072 dimer interface [polypeptide binding]; other site 926556007073 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 926556007074 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926556007075 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926556007076 active site 926556007077 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 926556007078 Pectate lyase; Region: Pec_lyase_C; cl01593 926556007079 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 926556007080 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 926556007081 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 926556007082 MerC mercury resistance protein; Region: MerC; pfam03203 926556007083 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926556007084 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926556007085 Walker A/P-loop; other site 926556007086 ATP binding site [chemical binding]; other site 926556007087 Q-loop/lid; other site 926556007088 ABC transporter signature motif; other site 926556007089 Walker B; other site 926556007090 D-loop; other site 926556007091 H-loop/switch region; other site 926556007092 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926556007093 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 926556007094 FtsX-like permease family; Region: FtsX; pfam02687 926556007095 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556007096 Sulfatase; Region: Sulfatase; pfam00884 926556007097 Sulfatase; Region: Sulfatase; cl17466 926556007098 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926556007099 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926556007100 ligand binding site [chemical binding]; other site 926556007101 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 926556007102 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926556007103 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 926556007104 putative hydrophobic ligand binding site [chemical binding]; other site 926556007105 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 926556007106 dimer interface [polypeptide binding]; other site 926556007107 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 926556007108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 926556007109 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556007110 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 926556007111 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 926556007112 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 926556007113 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 926556007114 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 926556007115 FecR protein; Region: FecR; pfam04773 926556007116 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556007117 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556007118 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556007119 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556007120 SusD family; Region: SusD; pfam07980 926556007121 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 926556007122 Domain of unknown function (DUF4361); Region: DUF4361; pfam14274 926556007123 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 926556007124 NHL repeat; Region: NHL; pfam01436 926556007125 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 926556007126 Peptidase of plants and bacteria; Region: BSP; pfam04450 926556007127 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556007128 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 926556007129 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 926556007130 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 926556007131 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556007132 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926556007133 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 926556007134 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926556007135 active site 926556007136 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 926556007137 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926556007138 active site 926556007139 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926556007140 active site 926556007141 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926556007142 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 926556007143 Probable Catalytic site; other site 926556007144 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926556007145 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926556007146 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 926556007147 Walker A/P-loop; other site 926556007148 ATP binding site [chemical binding]; other site 926556007149 Q-loop/lid; other site 926556007150 ABC transporter signature motif; other site 926556007151 Walker B; other site 926556007152 D-loop; other site 926556007153 H-loop/switch region; other site 926556007154 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 926556007155 GIY-YIG motif/motif A; other site 926556007156 putative active site [active] 926556007157 putative metal binding site [ion binding]; other site 926556007158 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 926556007159 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 926556007160 Probable Catalytic site; other site 926556007161 metal-binding site 926556007162 Glycosyl hydrolase family 43; Region: GH43_5; cd08984 926556007163 active site 926556007164 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 926556007165 active site 926556007166 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 926556007167 putative substrate binding site [chemical binding]; other site 926556007168 active site 926556007169 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 926556007170 putative substrate binding site [chemical binding]; other site 926556007171 active site 926556007172 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 926556007173 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 926556007174 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 926556007175 Asp-box motif; other site 926556007176 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 926556007177 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556007178 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556007179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556007180 DNA binding residues [nucleotide binding] 926556007181 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556007182 FecR protein; Region: FecR; pfam04773 926556007183 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556007184 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556007185 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556007186 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556007187 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556007188 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556007189 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 926556007190 Beta-lactamase; Region: Beta-lactamase; pfam00144 926556007191 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 926556007192 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 926556007193 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 926556007194 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926556007195 active site 926556007196 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926556007197 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 926556007198 active site 926556007199 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 926556007200 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 926556007201 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556007202 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556007203 dimer interface [polypeptide binding]; other site 926556007204 phosphorylation site [posttranslational modification] 926556007205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556007206 ATP binding site [chemical binding]; other site 926556007207 Mg2+ binding site [ion binding]; other site 926556007208 G-X-G motif; other site 926556007209 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926556007210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556007211 active site 926556007212 phosphorylation site [posttranslational modification] 926556007213 intermolecular recognition site; other site 926556007214 dimerization interface [polypeptide binding]; other site 926556007215 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 926556007216 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556007217 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556007218 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556007219 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556007220 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556007221 SusD family; Region: SusD; pfam07980 926556007222 Protein of unknown function (DUF3823); Region: DUF3823; pfam12866 926556007223 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 926556007224 putative substrate binding site [chemical binding]; other site 926556007225 active site 926556007226 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 926556007227 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926556007228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 926556007229 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556007230 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 926556007231 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 926556007232 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 926556007233 active site 926556007234 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926556007235 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556007236 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 926556007237 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926556007238 Ligand Binding Site [chemical binding]; other site 926556007239 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926556007240 Ligand Binding Site [chemical binding]; other site 926556007241 phosphoserine phosphatase SerB; Region: serB; TIGR00338 926556007242 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 926556007243 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 926556007244 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 926556007245 ligand binding site [chemical binding]; other site 926556007246 NAD binding site [chemical binding]; other site 926556007247 tetramer interface [polypeptide binding]; other site 926556007248 catalytic site [active] 926556007249 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 926556007250 L-serine binding site [chemical binding]; other site 926556007251 ACT domain interface; other site 926556007252 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 926556007253 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 926556007254 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926556007255 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926556007256 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556007257 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 926556007258 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 926556007259 tandem repeat interface [polypeptide binding]; other site 926556007260 oligomer interface [polypeptide binding]; other site 926556007261 active site residues [active] 926556007262 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 926556007263 tandem repeat interface [polypeptide binding]; other site 926556007264 oligomer interface [polypeptide binding]; other site 926556007265 active site residues [active] 926556007266 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 926556007267 catalytic center binding site [active] 926556007268 ATP binding site [chemical binding]; other site 926556007269 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139 926556007270 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 926556007271 HopJ type III effector protein; Region: HopJ; pfam08888 926556007272 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 926556007273 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 926556007274 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 926556007275 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 926556007276 inhibitor-cofactor binding pocket; inhibition site 926556007277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556007278 catalytic residue [active] 926556007279 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 926556007280 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 926556007281 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 926556007282 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926556007283 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 926556007284 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 926556007285 distal heme binding site [chemical binding]; other site 926556007286 proximal heme binding site [chemical binding]; other site 926556007287 putative dimer interface [polypeptide binding]; other site 926556007288 putative Iron-sulfur protein interface [polypeptide binding]; other site 926556007289 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 926556007290 L-aspartate oxidase; Provisional; Region: PRK06175 926556007291 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 926556007292 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 926556007293 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 926556007294 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 926556007295 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 926556007296 Na binding site [ion binding]; other site 926556007297 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 926556007298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926556007299 Coenzyme A binding pocket [chemical binding]; other site 926556007300 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 926556007301 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 926556007302 dimer interface [polypeptide binding]; other site 926556007303 active site 926556007304 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926556007305 substrate binding site [chemical binding]; other site 926556007306 catalytic residue [active] 926556007307 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926556007308 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926556007309 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556007310 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556007311 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 926556007312 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 926556007313 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 926556007314 putative substrate binding site [chemical binding]; other site 926556007315 putative ATP binding site [chemical binding]; other site 926556007316 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 926556007317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556007318 putative substrate translocation pore; other site 926556007319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556007320 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 926556007321 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 926556007322 substrate binding [chemical binding]; other site 926556007323 active site 926556007324 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 926556007325 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 926556007326 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 926556007327 substrate binding [chemical binding]; other site 926556007328 active site 926556007329 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556007330 SusD family; Region: SusD; pfam07980 926556007331 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556007332 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556007333 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556007334 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556007335 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 926556007336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556007337 putative substrate translocation pore; other site 926556007338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556007339 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 926556007340 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 926556007341 putative ligand binding site [chemical binding]; other site 926556007342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556007343 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556007344 dimer interface [polypeptide binding]; other site 926556007345 phosphorylation site [posttranslational modification] 926556007346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556007347 ATP binding site [chemical binding]; other site 926556007348 Mg2+ binding site [ion binding]; other site 926556007349 G-X-G motif; other site 926556007350 Response regulator receiver domain; Region: Response_reg; pfam00072 926556007351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556007352 active site 926556007353 phosphorylation site [posttranslational modification] 926556007354 intermolecular recognition site; other site 926556007355 dimerization interface [polypeptide binding]; other site 926556007356 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 926556007357 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556007358 Patatin-like phospholipase; Region: Patatin; pfam01734 926556007359 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 926556007360 putative cation:proton antiport protein; Provisional; Region: PRK10669 926556007361 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 926556007362 TrkA-N domain; Region: TrkA_N; pfam02254 926556007363 TrkA-C domain; Region: TrkA_C; pfam02080 926556007364 Protein of unknown function (DUF962); Region: DUF962; cl01879 926556007365 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 926556007366 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 926556007367 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 926556007368 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 926556007369 catalytic site [active] 926556007370 putative active site [active] 926556007371 putative substrate binding site [chemical binding]; other site 926556007372 Uncharacterized conserved protein [Function unknown]; Region: COG1739 926556007373 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 926556007374 WxcM-like, C-terminal; Region: FdtA; pfam05523 926556007375 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 926556007376 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 926556007377 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926556007378 active site 926556007379 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 926556007380 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 926556007381 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 926556007382 active site 926556007383 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 926556007384 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 926556007385 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 926556007386 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 926556007387 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 926556007388 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 926556007389 Surface antigen; Region: Bac_surface_Ag; pfam01103 926556007390 hypothetical protein; Provisional; Region: PRK11820 926556007391 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 926556007392 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 926556007393 thymidylate synthase; Reviewed; Region: thyA; PRK01827 926556007394 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 926556007395 dimerization interface [polypeptide binding]; other site 926556007396 active site 926556007397 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 926556007398 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 926556007399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556007400 catalytic residue [active] 926556007401 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 926556007402 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 926556007403 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 926556007404 putative L-serine binding site [chemical binding]; other site 926556007405 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 926556007406 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926556007407 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926556007408 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556007409 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 926556007410 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 926556007411 nucleoside/Zn binding site; other site 926556007412 dimer interface [polypeptide binding]; other site 926556007413 catalytic motif [active] 926556007414 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 926556007415 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556007416 putative active site [active] 926556007417 heme pocket [chemical binding]; other site 926556007418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556007419 dimer interface [polypeptide binding]; other site 926556007420 phosphorylation site [posttranslational modification] 926556007421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556007422 ATP binding site [chemical binding]; other site 926556007423 Mg2+ binding site [ion binding]; other site 926556007424 G-X-G motif; other site 926556007425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556007426 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926556007427 putative substrate translocation pore; other site 926556007428 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 926556007429 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 926556007430 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 926556007431 trimer interface [polypeptide binding]; other site 926556007432 active site 926556007433 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 926556007434 catalytic site [active] 926556007435 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926556007436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556007437 Walker A/P-loop; other site 926556007438 ATP binding site [chemical binding]; other site 926556007439 Q-loop/lid; other site 926556007440 ABC transporter signature motif; other site 926556007441 Walker B; other site 926556007442 D-loop; other site 926556007443 H-loop/switch region; other site 926556007444 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926556007445 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926556007446 DNA binding site [nucleotide binding] 926556007447 domain linker motif; other site 926556007448 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 926556007449 dimerization interface [polypeptide binding]; other site 926556007450 ligand binding site [chemical binding]; other site 926556007451 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556007452 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556007453 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556007454 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556007455 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556007456 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 926556007457 SusE outer membrane protein; Region: SusE; pfam14292 926556007458 Uncharacterized subgroup of the CBM-SusE-F_like superfamily; Region: CBM_SusE-F_like_u1; cd12967 926556007459 starch binding site [chemical binding]; other site 926556007460 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956 926556007461 starch binding site [chemical binding]; other site 926556007462 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 926556007463 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 926556007464 active site 926556007465 intersubunit interface [polypeptide binding]; other site 926556007466 zinc binding site [ion binding]; other site 926556007467 Na+ binding site [ion binding]; other site 926556007468 trehalose synthase; Region: treS_nterm; TIGR02456 926556007469 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 926556007470 Ca binding site [ion binding]; other site 926556007471 active site 926556007472 catalytic site [active] 926556007473 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 926556007474 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 926556007475 putative DNA binding site [nucleotide binding]; other site 926556007476 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556007477 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556007478 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556007479 DNA binding residues [nucleotide binding] 926556007480 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556007481 FecR protein; Region: FecR; pfam04773 926556007482 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556007483 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556007484 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556007485 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556007486 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 926556007487 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556007488 Uncharacterized protein family UPF0560; Region: UPF0560; pfam10577 926556007489 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 926556007490 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926556007491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556007492 homodimer interface [polypeptide binding]; other site 926556007493 catalytic residue [active] 926556007494 Membrane transport protein; Region: Mem_trans; cl09117 926556007495 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 926556007496 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 926556007497 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 926556007498 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 926556007499 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 926556007500 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 926556007501 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 926556007502 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 926556007503 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 926556007504 putative active site [active] 926556007505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926556007506 Coenzyme A binding pocket [chemical binding]; other site 926556007507 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556007508 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556007509 Autotransporter beta-domain; Region: Autotransporter; cl17461 926556007510 Predicted amidohydrolase [General function prediction only]; Region: COG0388 926556007511 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 926556007512 active site 926556007513 catalytic triad [active] 926556007514 dimer interface [polypeptide binding]; other site 926556007515 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 926556007516 HTH domain; Region: HTH_11; pfam08279 926556007517 WYL domain; Region: WYL; pfam13280 926556007518 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 926556007519 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 926556007520 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 926556007521 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926556007522 active site 926556007523 HIGH motif; other site 926556007524 nucleotide binding site [chemical binding]; other site 926556007525 active site 926556007526 KMSKS motif; other site 926556007527 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 926556007528 putative metal binding site [ion binding]; other site 926556007529 Uncharacterized conserved protein [Function unknown]; Region: COG1432 926556007530 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 926556007531 Peptidase family M48; Region: Peptidase_M48; pfam01435 926556007532 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 926556007533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926556007534 Coenzyme A binding pocket [chemical binding]; other site 926556007535 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 926556007536 Uncharacterized conserved protein [Function unknown]; Region: COG2128 926556007537 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 926556007538 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556007539 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556007540 DNA binding residues [nucleotide binding] 926556007541 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926556007542 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926556007543 ligand binding site [chemical binding]; other site 926556007544 flexible hinge region; other site 926556007545 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 926556007546 putative switch regulator; other site 926556007547 non-specific DNA interactions [nucleotide binding]; other site 926556007548 DNA binding site [nucleotide binding] 926556007549 sequence specific DNA binding site [nucleotide binding]; other site 926556007550 putative cAMP binding site [chemical binding]; other site 926556007551 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 926556007552 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 926556007553 Heavy-metal-associated domain; Region: HMA; pfam00403 926556007554 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926556007555 Soluble P-type ATPase [General function prediction only]; Region: COG4087 926556007556 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 926556007557 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 926556007558 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 926556007559 Low-spin heme binding site [chemical binding]; other site 926556007560 Putative water exit pathway; other site 926556007561 Binuclear center (active site) [active] 926556007562 Putative proton exit pathway; other site 926556007563 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 926556007564 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 926556007565 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 926556007566 Cytochrome c; Region: Cytochrom_C; pfam00034 926556007567 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 926556007568 4Fe-4S binding domain; Region: Fer4_5; pfam12801 926556007569 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 926556007570 FixH; Region: FixH; pfam05751 926556007571 Family description; Region: DsbD_2; pfam13386 926556007572 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926556007573 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556007574 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556007575 DNA binding residues [nucleotide binding] 926556007576 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926556007577 YceI-like domain; Region: YceI; pfam04264 926556007578 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926556007579 DNA binding site [nucleotide binding] 926556007580 domain linker motif; other site 926556007581 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 926556007582 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 926556007583 ligand binding site [chemical binding]; other site 926556007584 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556007585 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556007586 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556007587 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556007588 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 926556007589 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556007590 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556007591 Sulfatase; Region: Sulfatase; pfam00884 926556007592 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 926556007593 active site 926556007594 catalytic triad [active] 926556007595 oxyanion hole [active] 926556007596 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 926556007597 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 926556007598 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926556007599 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556007600 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 926556007601 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 926556007602 active site 926556007603 metal binding site [ion binding]; metal-binding site 926556007604 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 926556007605 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 926556007606 CoA-ligase; Region: Ligase_CoA; pfam00549 926556007607 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926556007608 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926556007609 Walker A/P-loop; other site 926556007610 ATP binding site [chemical binding]; other site 926556007611 Q-loop/lid; other site 926556007612 ABC transporter signature motif; other site 926556007613 Walker B; other site 926556007614 D-loop; other site 926556007615 H-loop/switch region; other site 926556007616 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 926556007617 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 926556007618 catalytic triad [active] 926556007619 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 926556007620 EamA-like transporter family; Region: EamA; pfam00892 926556007621 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 926556007622 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 926556007623 active site 926556007624 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 926556007625 Isochorismatase family; Region: Isochorismatase; pfam00857 926556007626 catalytic triad [active] 926556007627 metal binding site [ion binding]; metal-binding site 926556007628 conserved cis-peptide bond; other site 926556007629 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 926556007630 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 926556007631 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 926556007632 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 926556007633 dimer interface [polypeptide binding]; other site 926556007634 decamer (pentamer of dimers) interface [polypeptide binding]; other site 926556007635 catalytic triad [active] 926556007636 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 926556007637 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 926556007638 inhibitor-cofactor binding pocket; inhibition site 926556007639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556007640 catalytic residue [active] 926556007641 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 926556007642 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 926556007643 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556007644 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556007645 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926556007646 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556007647 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926556007648 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 926556007649 Helix-turn-helix domain; Region: HTH_18; pfam12833 926556007650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556007651 Methane oxygenase PmoA; Region: PmoA; pfam14100 926556007652 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 926556007653 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 926556007654 PYR/PP interface [polypeptide binding]; other site 926556007655 dimer interface [polypeptide binding]; other site 926556007656 TPP binding site [chemical binding]; other site 926556007657 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 926556007658 transketolase; Reviewed; Region: PRK05899 926556007659 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 926556007660 TPP-binding site [chemical binding]; other site 926556007661 dimer interface [polypeptide binding]; other site 926556007662 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 926556007663 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556007664 catalytic triad [active] 926556007665 Peptidase family M23; Region: Peptidase_M23; pfam01551 926556007666 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 926556007667 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 926556007668 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 926556007669 Pirin-related protein [General function prediction only]; Region: COG1741 926556007670 Pirin; Region: Pirin; pfam02678 926556007671 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 926556007672 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 926556007673 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926556007674 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926556007675 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 926556007676 Walker A/P-loop; other site 926556007677 ATP binding site [chemical binding]; other site 926556007678 Q-loop/lid; other site 926556007679 ABC transporter signature motif; other site 926556007680 Walker B; other site 926556007681 D-loop; other site 926556007682 H-loop/switch region; other site 926556007683 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 926556007684 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 926556007685 Penicillinase repressor; Region: Pencillinase_R; pfam03965 926556007686 Domain of unknown function (DUF718); Region: DUF718; pfam05336 926556007687 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 926556007688 Amidohydrolase; Region: Amidohydro_2; pfam04909 926556007689 active site 926556007690 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 926556007691 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 926556007692 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 926556007693 classical (c) SDRs; Region: SDR_c; cd05233 926556007694 NAD(P) binding site [chemical binding]; other site 926556007695 active site 926556007696 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 926556007697 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 926556007698 putative active site pocket [active] 926556007699 metal binding site [ion binding]; metal-binding site 926556007700 Cupin domain; Region: Cupin_2; cl17218 926556007701 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 926556007702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556007703 hypothetical protein; Provisional; Region: PRK09256 926556007704 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 926556007705 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 926556007706 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 926556007707 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 926556007708 replicative DNA helicase; Region: DnaB; TIGR00665 926556007709 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 926556007710 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 926556007711 Walker A motif; other site 926556007712 ATP binding site [chemical binding]; other site 926556007713 Walker B motif; other site 926556007714 DNA binding loops [nucleotide binding] 926556007715 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 926556007716 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 926556007717 NAD(P) binding site [chemical binding]; other site 926556007718 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 926556007719 Ligand binding site [chemical binding]; other site 926556007720 Electron transfer flavoprotein domain; Region: ETF; pfam01012 926556007721 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 926556007722 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 926556007723 Ligand Binding Site [chemical binding]; other site 926556007724 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 926556007725 Bifunctional nuclease; Region: DNase-RNase; pfam02577 926556007726 UvrB/uvrC motif; Region: UVR; pfam02151 926556007727 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 926556007728 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 926556007729 Nucleoside recognition; Region: Gate; pfam07670 926556007730 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 926556007731 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 926556007732 active site 926556007733 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 926556007734 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 926556007735 active site 926556007736 substrate-binding site [chemical binding]; other site 926556007737 metal-binding site [ion binding] 926556007738 ATP binding site [chemical binding]; other site 926556007739 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 926556007740 POT family; Region: PTR2; cl17359 926556007741 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 926556007742 Bacterial sugar transferase; Region: Bac_transf; pfam02397 926556007743 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 926556007744 serine O-acetyltransferase; Region: cysE; TIGR01172 926556007745 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 926556007746 trimer interface [polypeptide binding]; other site 926556007747 active site 926556007748 substrate binding site [chemical binding]; other site 926556007749 CoA binding site [chemical binding]; other site 926556007750 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1817 926556007751 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926556007752 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556007753 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926556007754 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926556007755 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556007756 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 926556007757 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 926556007758 putative active site [active] 926556007759 putative metal binding site [ion binding]; other site 926556007760 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 926556007761 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 926556007762 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 926556007763 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 926556007764 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 926556007765 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926556007766 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926556007767 active site 926556007768 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 926556007769 Chain length determinant protein; Region: Wzz; cl15801 926556007770 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 926556007771 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 926556007772 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 926556007773 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 926556007774 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 926556007775 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 926556007776 catalytic motif [active] 926556007777 Zn binding site [ion binding]; other site 926556007778 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 926556007779 FAD binding domain; Region: FAD_binding_4; pfam01565 926556007780 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 926556007781 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 926556007782 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 926556007783 putative active site [active] 926556007784 Zn binding site [ion binding]; other site 926556007785 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 926556007786 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 926556007787 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 926556007788 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 926556007789 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 926556007790 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 926556007791 active site 926556007792 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 926556007793 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 926556007794 active site 926556007795 substrate binding site [chemical binding]; other site 926556007796 metal binding site [ion binding]; metal-binding site 926556007797 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 926556007798 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 926556007799 dimer interface [polypeptide binding]; other site 926556007800 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 926556007801 active site 926556007802 Fe binding site [ion binding]; other site 926556007803 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706 926556007804 substrate binding site [chemical binding]; other site 926556007805 catalytic residues [active] 926556007806 Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171 926556007807 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 926556007808 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 926556007809 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 926556007810 active site 926556007811 HIGH motif; other site 926556007812 dimer interface [polypeptide binding]; other site 926556007813 KMSKS motif; other site 926556007814 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 926556007815 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 926556007816 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 926556007817 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 926556007818 active site 926556007819 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 926556007820 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 926556007821 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 926556007822 CoA binding domain; Region: CoA_binding_2; pfam13380 926556007823 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 926556007824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556007825 ATP binding site [chemical binding]; other site 926556007826 Mg2+ binding site [ion binding]; other site 926556007827 G-X-G motif; other site 926556007828 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 926556007829 anchoring element; other site 926556007830 dimer interface [polypeptide binding]; other site 926556007831 ATP binding site [chemical binding]; other site 926556007832 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 926556007833 active site 926556007834 putative metal-binding site [ion binding]; other site 926556007835 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 926556007836 polyphosphate kinase; Provisional; Region: PRK05443 926556007837 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 926556007838 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 926556007839 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 926556007840 putative domain interface [polypeptide binding]; other site 926556007841 putative active site [active] 926556007842 catalytic site [active] 926556007843 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 926556007844 putative domain interface [polypeptide binding]; other site 926556007845 putative active site [active] 926556007846 catalytic site [active] 926556007847 exopolyphosphatase; Region: exo_poly_only; TIGR03706 926556007848 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 926556007849 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 926556007850 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 926556007851 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 926556007852 transmembrane helices; other site 926556007853 TrkA-C domain; Region: TrkA_C; pfam02080 926556007854 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 926556007855 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 926556007856 Domain of unknown function (DUF202); Region: DUF202; pfam02656 926556007857 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 926556007858 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 926556007859 nucleophile elbow; other site 926556007860 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 926556007861 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 926556007862 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 926556007863 Putative esterase; Region: Esterase; pfam00756 926556007864 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926556007865 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556007866 catalytic residues [active] 926556007867 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 926556007868 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 926556007869 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 926556007870 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801 926556007871 putative active site [active] 926556007872 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 926556007873 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 926556007874 RmuC family; Region: RmuC; pfam02646 926556007875 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 926556007876 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 926556007877 active site 926556007878 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 926556007879 TrkA-N domain; Region: TrkA_N; pfam02254 926556007880 TrkA-C domain; Region: TrkA_C; pfam02080 926556007881 TrkA-N domain; Region: TrkA_N; pfam02254 926556007882 TrkA-C domain; Region: TrkA_C; pfam02080 926556007883 Cation transport protein; Region: TrkH; cl17365 926556007884 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 926556007885 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 926556007886 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 926556007887 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 926556007888 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556007889 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 926556007890 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556007891 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556007892 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556007893 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 926556007894 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 926556007895 active site 926556007896 catalytic triad [active] 926556007897 calcium binding site 1 [ion binding]; other site 926556007898 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 926556007899 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 926556007900 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 926556007901 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 926556007902 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 926556007903 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 926556007904 active site 926556007905 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 926556007906 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 926556007907 Sulfate transporter family; Region: Sulfate_transp; pfam00916 926556007908 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 926556007909 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 926556007910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556007911 S-adenosylmethionine binding site [chemical binding]; other site 926556007912 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 926556007913 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 926556007914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556007915 active site 926556007916 phosphorylation site [posttranslational modification] 926556007917 intermolecular recognition site; other site 926556007918 dimerization interface [polypeptide binding]; other site 926556007919 LytTr DNA-binding domain; Region: LytTR; smart00850 926556007920 Histidine kinase; Region: His_kinase; pfam06580 926556007921 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926556007922 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926556007923 DNA binding site [nucleotide binding] 926556007924 domain linker motif; other site 926556007925 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 926556007926 dimerization interface [polypeptide binding]; other site 926556007927 ligand binding site [chemical binding]; other site 926556007928 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 926556007929 Peptidase family M23; Region: Peptidase_M23; pfam01551 926556007930 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 926556007931 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 926556007932 motif 1; other site 926556007933 active site 926556007934 motif 2; other site 926556007935 motif 3; other site 926556007936 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 926556007937 DHHA1 domain; Region: DHHA1; pfam02272 926556007938 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 926556007939 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 926556007940 GatB domain; Region: GatB_Yqey; smart00845 926556007941 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 926556007942 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926556007943 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556007944 catalytic residues [active] 926556007945 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 926556007946 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 926556007947 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 926556007948 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 926556007949 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 926556007950 Uncharacterized conserved protein [Function unknown]; Region: COG1262 926556007951 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 926556007952 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 926556007953 PA26 p53-induced protein (sestrin); Region: PA26; pfam04636 926556007954 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 926556007955 Ferritin-like domain; Region: Ferritin; pfam00210 926556007956 ferroxidase diiron center [ion binding]; other site 926556007957 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 926556007958 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 926556007959 Ligand binding site; other site 926556007960 oligomer interface; other site 926556007961 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 926556007962 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926556007963 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926556007964 ligand binding site [chemical binding]; other site 926556007965 flexible hinge region; other site 926556007966 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 926556007967 RNA methyltransferase, RsmE family; Region: TIGR00046 926556007968 helicase 45; Provisional; Region: PTZ00424 926556007969 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 926556007970 ATP binding site [chemical binding]; other site 926556007971 Mg++ binding site [ion binding]; other site 926556007972 motif III; other site 926556007973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926556007974 nucleotide binding region [chemical binding]; other site 926556007975 ATP-binding site [chemical binding]; other site 926556007976 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 926556007977 RNA binding site [nucleotide binding]; other site 926556007978 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 926556007979 dimer interface [polypeptide binding]; other site 926556007980 Citrate synthase; Region: Citrate_synt; pfam00285 926556007981 active site 926556007982 citrylCoA binding site [chemical binding]; other site 926556007983 NADH binding [chemical binding]; other site 926556007984 cationic pore residues; other site 926556007985 oxalacetate/citrate binding site [chemical binding]; other site 926556007986 coenzyme A binding site [chemical binding]; other site 926556007987 catalytic triad [active] 926556007988 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 926556007989 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 926556007990 Fe-S metabolism associated domain; Region: SufE; cl00951 926556007991 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 926556007992 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 926556007993 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926556007994 catalytic residue [active] 926556007995 FeS assembly protein SufD; Region: sufD; TIGR01981 926556007996 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 926556007997 FeS assembly ATPase SufC; Region: sufC; TIGR01978 926556007998 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 926556007999 Walker A/P-loop; other site 926556008000 ATP binding site [chemical binding]; other site 926556008001 Q-loop/lid; other site 926556008002 ABC transporter signature motif; other site 926556008003 Walker B; other site 926556008004 D-loop; other site 926556008005 H-loop/switch region; other site 926556008006 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 926556008007 putative ABC transporter; Region: ycf24; CHL00085 926556008008 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 926556008009 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926556008010 putative DNA binding site [nucleotide binding]; other site 926556008011 putative Zn2+ binding site [ion binding]; other site 926556008012 AsnC family; Region: AsnC_trans_reg; pfam01037 926556008013 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 926556008014 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926556008015 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 926556008016 altronate oxidoreductase; Provisional; Region: PRK03643 926556008017 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 926556008018 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 926556008019 Glucuronate isomerase; Region: UxaC; pfam02614 926556008020 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 926556008021 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926556008022 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926556008023 DNA binding site [nucleotide binding] 926556008024 domain linker motif; other site 926556008025 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 926556008026 dimerization interface [polypeptide binding]; other site 926556008027 ligand binding site [chemical binding]; other site 926556008028 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 926556008029 Pectinesterase; Region: Pectinesterase; pfam01095 926556008030 putative pectinesterase; Region: PLN02432; cl01911 926556008031 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 926556008032 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 926556008033 active site 926556008034 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 926556008035 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 926556008036 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 926556008037 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 926556008038 active site 926556008039 catalytic triad [active] 926556008040 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 926556008041 active site 926556008042 catalytic triad [active] 926556008043 Pectinesterase; Region: Pectinesterase; pfam01095 926556008044 putative pectinesterase; Region: PLN02432; cl01911 926556008045 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 926556008046 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926556008047 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556008048 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556008049 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556008050 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556008051 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556008052 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556008053 Pectate lyase; Region: Pec_lyase_C; cl01593 926556008054 Pectinesterase; Region: Pectinesterase; pfam01095 926556008055 putative pectinesterase; Region: PLN02432; cl01911 926556008056 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926556008057 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 926556008058 active site 926556008059 metal binding site [ion binding]; metal-binding site 926556008060 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 926556008061 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 926556008062 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 926556008063 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 926556008064 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556008065 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556008066 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 926556008067 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 926556008068 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 926556008069 Sulfatase; Region: Sulfatase; cl17466 926556008070 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556008071 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 926556008072 amphipathic channel; other site 926556008073 Asn-Pro-Ala signature motifs; other site 926556008074 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556008075 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556008076 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 926556008077 mannonate dehydratase; Provisional; Region: PRK03906 926556008078 mannonate dehydratase; Region: uxuA; TIGR00695 926556008079 D-mannonate oxidoreductase; Provisional; Region: PRK08277 926556008080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926556008081 NAD(P) binding site [chemical binding]; other site 926556008082 active site 926556008083 Glucuronate isomerase; Region: UxaC; pfam02614 926556008084 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 926556008085 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926556008086 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926556008087 DNA binding site [nucleotide binding] 926556008088 domain linker motif; other site 926556008089 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 926556008090 dimerization interface [polypeptide binding]; other site 926556008091 ligand binding site [chemical binding]; other site 926556008092 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556008093 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556008094 SusD family; Region: SusD; pfam07980 926556008095 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556008096 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556008097 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556008098 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556008099 D-galactonate transporter; Region: 2A0114; TIGR00893 926556008100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556008101 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 926556008102 Predicted transcriptional regulator [Transcription]; Region: COG2378 926556008103 HTH domain; Region: HTH_11; pfam08279 926556008104 WYL domain; Region: WYL; pfam13280 926556008105 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 926556008106 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 926556008107 intersubunit interface [polypeptide binding]; other site 926556008108 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 926556008109 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 926556008110 ABC-ATPase subunit interface; other site 926556008111 dimer interface [polypeptide binding]; other site 926556008112 putative PBP binding regions; other site 926556008113 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 926556008114 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 926556008115 Walker A/P-loop; other site 926556008116 ATP binding site [chemical binding]; other site 926556008117 Q-loop/lid; other site 926556008118 ABC transporter signature motif; other site 926556008119 Walker B; other site 926556008120 D-loop; other site 926556008121 H-loop/switch region; other site 926556008122 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 926556008123 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 926556008124 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 926556008125 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 926556008126 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 926556008127 N-terminal plug; other site 926556008128 ligand-binding site [chemical binding]; other site 926556008129 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 926556008130 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 926556008131 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; pfam10142 926556008132 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 926556008133 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 926556008134 active site 926556008135 metal binding site [ion binding]; metal-binding site 926556008136 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 926556008137 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 926556008138 putative active site [active] 926556008139 catalytic site [active] 926556008140 putative metal binding site [ion binding]; other site 926556008141 oligomer interface [polypeptide binding]; other site 926556008142 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926556008143 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926556008144 ligand binding site [chemical binding]; other site 926556008145 flexible hinge region; other site 926556008146 amidohydrolase; Region: amidohydrolases; TIGR01891 926556008147 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 926556008148 metal binding site [ion binding]; metal-binding site 926556008149 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 926556008150 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 926556008151 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 926556008152 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 926556008153 metal ion-dependent adhesion site (MIDAS); other site 926556008154 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556008155 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556008156 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556008157 DNA binding residues [nucleotide binding] 926556008158 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556008159 FecR protein; Region: FecR; pfam04773 926556008160 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556008161 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556008162 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556008163 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556008164 SusD family; Region: SusD; pfam07980 926556008165 agmatinase; Region: agmatinase; TIGR01230 926556008166 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 926556008167 putative active site [active] 926556008168 Mn binding site [ion binding]; other site 926556008169 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 926556008170 catalytic core [active] 926556008171 DNA topoisomerase I; Provisional; Region: PRK08780 926556008172 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 926556008173 active site 926556008174 interdomain interaction site; other site 926556008175 putative metal-binding site [ion binding]; other site 926556008176 nucleotide binding site [chemical binding]; other site 926556008177 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 926556008178 domain I; other site 926556008179 DNA binding groove [nucleotide binding] 926556008180 phosphate binding site [ion binding]; other site 926556008181 domain II; other site 926556008182 domain III; other site 926556008183 nucleotide binding site [chemical binding]; other site 926556008184 catalytic site [active] 926556008185 domain IV; other site 926556008186 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 926556008187 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 926556008188 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 926556008189 NAD-dependent deacetylase; Provisional; Region: PRK00481 926556008190 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 926556008191 NAD+ binding site [chemical binding]; other site 926556008192 substrate binding site [chemical binding]; other site 926556008193 Zn binding site [ion binding]; other site 926556008194 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 926556008195 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 926556008196 catalytic residues [active] 926556008197 catalytic nucleophile [active] 926556008198 Recombinase; Region: Recombinase; pfam07508 926556008199 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 926556008200 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 926556008201 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 926556008202 catalytic residues [active] 926556008203 catalytic nucleophile [active] 926556008204 Recombinase; Region: Recombinase; pfam07508 926556008205 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 926556008206 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 926556008207 dimer interface [polypeptide binding]; other site 926556008208 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 926556008209 ssDNA binding site [nucleotide binding]; other site 926556008210 tetramer (dimer of dimers) interface [polypeptide binding]; other site 926556008211 Domain of unknown function (DUF932); Region: DUF932; pfam06067 926556008212 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 926556008213 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 926556008214 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 926556008215 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 926556008216 Helix-turn-helix domain; Region: HTH_18; pfam12833 926556008217 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926556008218 metal-binding site [ion binding] 926556008219 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926556008220 Ligand Binding Site [chemical binding]; other site 926556008221 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 926556008222 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926556008223 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926556008224 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PRK04207 926556008225 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 926556008226 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 926556008227 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 926556008228 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 926556008229 putative active site; other site 926556008230 catalytic residue [active] 926556008231 6-phosphofructokinase; Provisional; Region: PRK03202 926556008232 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 926556008233 active site 926556008234 ADP/pyrophosphate binding site [chemical binding]; other site 926556008235 dimerization interface [polypeptide binding]; other site 926556008236 allosteric effector site; other site 926556008237 fructose-1,6-bisphosphate binding site; other site 926556008238 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 926556008239 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 926556008240 putative ligand binding site [chemical binding]; other site 926556008241 putative NAD binding site [chemical binding]; other site 926556008242 catalytic site [active] 926556008243 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926556008244 Ligand Binding Site [chemical binding]; other site 926556008245 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926556008246 Ligand Binding Site [chemical binding]; other site 926556008247 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 926556008248 putative active site [active] 926556008249 DNA polymerase III subunit delta; Validated; Region: PRK07452 926556008250 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 926556008251 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 926556008252 Beta-Casp domain; Region: Beta-Casp; pfam10996 926556008253 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 926556008254 thymidine phosphorylase; Provisional; Region: PRK04350 926556008255 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 926556008256 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 926556008257 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 926556008258 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 926556008259 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 926556008260 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926556008261 active site 926556008262 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 926556008263 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926556008264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926556008265 motif II; other site 926556008266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556008267 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926556008268 putative substrate translocation pore; other site 926556008269 Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988 926556008270 Conjugative transposon protein TraO; Region: TraO; pfam10626 926556008271 Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780 926556008272 Domain of unknown function (DUF4138); Region: DUF4138; pfam13595 926556008273 Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779 926556008274 Protein of unknown function (DUF3714); Region: DUF3714; pfam12508 926556008275 Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781 926556008276 Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782 926556008277 Domain of unknown function (DUF4141); Region: DUF4141; pfam13605 926556008278 Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783 926556008279 Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991 926556008280 Domain of unknown function (DUF4133); Region: DUF4133; pfam13571 926556008281 Domain of unknown function (DUF4134); Region: DUF4134; pfam13572 926556008282 Putative catalytic domain of uncharacterized hypothetical proteins closely related to Nuc, , an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar2; cd09174 926556008283 PLD-like domain; Region: PLDc_2; pfam13091 926556008284 putative active site [active] 926556008285 catalytic site [active] 926556008286 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 926556008287 active site 926556008288 NTP binding site [chemical binding]; other site 926556008289 metal binding triad [ion binding]; metal-binding site 926556008290 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 926556008291 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926556008292 Domain of unknown function (DUF955); Region: DUF955; pfam06114 926556008293 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 926556008294 MerT mercuric transport protein; Region: MerT; cl03578 926556008295 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926556008296 metal-binding site [ion binding] 926556008297 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 926556008298 putative homotetramer interface [polypeptide binding]; other site 926556008299 putative homodimer interface [polypeptide binding]; other site 926556008300 putative allosteric switch controlling residues; other site 926556008301 putative metal binding site [ion binding]; other site 926556008302 putative homodimer-homodimer interface [polypeptide binding]; other site 926556008303 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926556008304 putative DNA binding site [nucleotide binding]; other site 926556008305 putative Zn2+ binding site [ion binding]; other site 926556008306 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926556008307 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 926556008308 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 926556008309 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 926556008310 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 926556008311 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 926556008312 Multicopper oxidase; Region: Cu-oxidase; pfam00394 926556008313 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 926556008314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556008315 S-adenosylmethionine binding site [chemical binding]; other site 926556008316 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 926556008317 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926556008318 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556008319 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 926556008320 Outer membrane efflux protein; Region: OEP; pfam02321 926556008321 Outer membrane efflux protein; Region: OEP; pfam02321 926556008322 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 926556008323 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 926556008324 YceI-like domain; Region: YceI; cl01001 926556008325 YceI-like domain; Region: YceI; pfam04264 926556008326 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 926556008327 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 926556008328 NAD binding site [chemical binding]; other site 926556008329 substrate binding site [chemical binding]; other site 926556008330 catalytic Zn binding site [ion binding]; other site 926556008331 tetramer interface [polypeptide binding]; other site 926556008332 structural Zn binding site [ion binding]; other site 926556008333 Helix-turn-helix domain; Region: HTH_18; pfam12833 926556008334 Protein of unknown function (DUF3408); Region: DUF3408; pfam11888 926556008335 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 926556008336 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 926556008337 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 926556008338 YWFCY protein; Region: YWFCY; pfam14293 926556008339 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 926556008340 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 926556008341 RteC protein; Region: RteC; pfam09357 926556008342 Methyltransferase domain; Region: Methyltransf_26; pfam13659 926556008343 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 926556008344 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 926556008345 helicase superfamily c-terminal domain; Region: HELICc; smart00490 926556008346 ATP-binding site [chemical binding]; other site 926556008347 Domain of unknown function (DUF1896); Region: DUF1896; pfam08989 926556008348 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 926556008349 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 926556008350 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 926556008351 DNA topoisomerase III; Provisional; Region: PRK07726 926556008352 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 926556008353 active site 926556008354 putative interdomain interaction site [polypeptide binding]; other site 926556008355 putative metal-binding site [ion binding]; other site 926556008356 putative nucleotide binding site [chemical binding]; other site 926556008357 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 926556008358 domain I; other site 926556008359 DNA binding groove [nucleotide binding] 926556008360 phosphate binding site [ion binding]; other site 926556008361 domain II; other site 926556008362 domain III; other site 926556008363 nucleotide binding site [chemical binding]; other site 926556008364 catalytic site [active] 926556008365 domain IV; other site 926556008366 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 926556008367 Protein of unknown function (DUF4099); Region: DUF4099; pfam13351 926556008368 Protein of unknown function (DUF3945); Region: DUF3945; pfam13101 926556008369 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 926556008370 Helix-turn-helix domain; Region: HTH_17; pfam12728 926556008371 RteC protein; Region: RteC; pfam09357 926556008372 Protein of unknown function, DUF417; Region: DUF417; cl01162 926556008373 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 926556008374 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 926556008375 active site 926556008376 catalytic residues [active] 926556008377 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926556008378 active site 926556008379 Protein of unknown function, DUF481; Region: DUF481; cl01213 926556008380 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926556008381 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926556008382 Glycine zipper; Region: Gly-zipper_Omp; cl17724 926556008383 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926556008384 ligand binding site [chemical binding]; other site 926556008385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556008386 TPR motif; other site 926556008387 binding surface 926556008388 TPR repeat; Region: TPR_11; pfam13414 926556008389 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 926556008390 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 926556008391 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 926556008392 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556008393 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 926556008394 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556008395 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 926556008396 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 926556008397 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 926556008398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 926556008399 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 926556008400 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926556008401 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 926556008402 Receptor L domain; Region: Recep_L_domain; pfam01030 926556008403 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 926556008404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556008405 Walker A motif; other site 926556008406 ATP binding site [chemical binding]; other site 926556008407 Walker B motif; other site 926556008408 arginine finger; other site 926556008409 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 926556008410 Integrase core domain; Region: rve; pfam00665 926556008411 Rhomboid family; Region: Rhomboid; pfam01694 926556008412 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 926556008413 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 926556008414 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 926556008415 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 926556008416 active site 926556008417 Riboflavin kinase; Region: Flavokinase; smart00904 926556008418 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 926556008419 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 926556008420 RNA binding site [nucleotide binding]; other site 926556008421 active site 926556008422 Bacitracin resistance protein BacA; Region: BacA; pfam02673 926556008423 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 926556008424 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 926556008425 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 926556008426 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 926556008427 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 926556008428 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926556008429 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 926556008430 active site 926556008431 metal binding site [ion binding]; metal-binding site 926556008432 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 926556008433 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 926556008434 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 926556008435 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 926556008436 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 926556008437 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 926556008438 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 926556008439 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556008440 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556008441 Penicillinase repressor; Region: Pencillinase_R; pfam03965 926556008442 Fatty acid desaturase; Region: FA_desaturase; pfam00487 926556008443 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 926556008444 Di-iron ligands [ion binding]; other site 926556008445 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 926556008446 Membrane protein of unknown function; Region: DUF360; pfam04020 926556008447 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 926556008448 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 926556008449 putative active site [active] 926556008450 Zn binding site [ion binding]; other site 926556008451 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 926556008452 periplasmic chaperone; Provisional; Region: PRK10780 926556008453 Deoxyhypusine synthase; Region: DS; cl00826 926556008454 deoxyhypusine synthase; Region: dhys; TIGR00321 926556008455 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926556008456 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926556008457 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926556008458 ligand binding site [chemical binding]; other site 926556008459 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 926556008460 putative hydrophobic ligand binding site [chemical binding]; other site 926556008461 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 926556008462 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926556008463 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 926556008464 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 926556008465 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 926556008466 Substrate-binding site [chemical binding]; other site 926556008467 Substrate specificity [chemical binding]; other site 926556008468 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 926556008469 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 926556008470 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 926556008471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 926556008472 Transposase; Region: DEDD_Tnp_IS110; pfam01548 926556008473 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 926556008474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556008475 non-specific DNA binding site [nucleotide binding]; other site 926556008476 salt bridge; other site 926556008477 sequence-specific DNA binding site [nucleotide binding]; other site 926556008478 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 926556008479 S1 domain; Region: S1_2; pfam13509 926556008480 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 926556008481 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 926556008482 ArsC family; Region: ArsC; pfam03960 926556008483 Flagellin N-methylase; Region: FliB; pfam03692 926556008484 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 926556008485 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926556008486 nucleotide binding site [chemical binding]; other site 926556008487 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 926556008488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556008489 ATP binding site [chemical binding]; other site 926556008490 Mg2+ binding site [ion binding]; other site 926556008491 G-X-G motif; other site 926556008492 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 926556008493 ATP binding site [chemical binding]; other site 926556008494 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 926556008495 active site 926556008496 putative metal-binding site [ion binding]; other site 926556008497 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 926556008498 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 926556008499 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 926556008500 CAP-like domain; other site 926556008501 active site 926556008502 primary dimer interface [polypeptide binding]; other site 926556008503 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 926556008504 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 926556008505 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 926556008506 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 926556008507 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 926556008508 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 926556008509 GIY-YIG motif/motif A; other site 926556008510 active site 926556008511 catalytic site [active] 926556008512 putative DNA binding site [nucleotide binding]; other site 926556008513 metal binding site [ion binding]; metal-binding site 926556008514 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556008515 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 926556008516 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 926556008517 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 926556008518 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 926556008519 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 926556008520 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 926556008521 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 926556008522 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 926556008523 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 926556008524 active site 926556008525 Zn binding site [ion binding]; other site 926556008526 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 926556008527 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 926556008528 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 926556008529 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 926556008530 PhnA protein; Region: PhnA; pfam03831 926556008531 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 926556008532 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 926556008533 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 926556008534 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 926556008535 Zonular occludens toxin (Zot); Region: Zot; cl17485 926556008536 flavoprotein, HI0933 family; Region: TIGR00275 926556008537 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926556008538 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 926556008539 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 926556008540 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 926556008541 active site 926556008542 FMN binding site [chemical binding]; other site 926556008543 substrate binding site [chemical binding]; other site 926556008544 3Fe-4S cluster binding site [ion binding]; other site 926556008545 Transcriptional regulators [Transcription]; Region: MarR; COG1846 926556008546 MarR family; Region: MarR; pfam01047 926556008547 Predicted membrane protein [Function unknown]; Region: COG4270 926556008548 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 926556008549 H+ Antiporter protein; Region: 2A0121; TIGR00900 926556008550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556008551 putative substrate translocation pore; other site 926556008552 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 926556008553 Isochorismatase family; Region: Isochorismatase; pfam00857 926556008554 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 926556008555 catalytic triad [active] 926556008556 conserved cis-peptide bond; other site 926556008557 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926556008558 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 926556008559 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 926556008560 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 926556008561 hydroxyglutarate oxidase; Provisional; Region: PRK11728 926556008562 Predicted dehydrogenase [General function prediction only]; Region: COG0579 926556008563 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 926556008564 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 926556008565 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 926556008566 putative RNA binding site [nucleotide binding]; other site 926556008567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556008568 S-adenosylmethionine binding site [chemical binding]; other site 926556008569 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 926556008570 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926556008571 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926556008572 ABC transporter; Region: ABC_tran_2; pfam12848 926556008573 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926556008574 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 926556008575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556008576 putative substrate translocation pore; other site 926556008577 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 926556008578 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 926556008579 threonine dehydratase; Validated; Region: PRK08639 926556008580 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 926556008581 tetramer interface [polypeptide binding]; other site 926556008582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556008583 catalytic residue [active] 926556008584 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 926556008585 Protein of unknown function (DUF502); Region: DUF502; cl01107 926556008586 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 926556008587 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 926556008588 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 926556008589 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 926556008590 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 926556008591 active site 926556008592 nucleophile elbow; other site 926556008593 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 926556008594 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 926556008595 putative acyl-acceptor binding pocket; other site 926556008596 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 926556008597 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 926556008598 classical (c) SDRs; Region: SDR_c; cd05233 926556008599 NAD(P) binding site [chemical binding]; other site 926556008600 active site 926556008601 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926556008602 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926556008603 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 926556008604 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 926556008605 active site 926556008606 HIGH motif; other site 926556008607 dimer interface [polypeptide binding]; other site 926556008608 KMSKS motif; other site 926556008609 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 926556008610 GSCFA family; Region: GSCFA; pfam08885 926556008611 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 926556008612 TM2 domain; Region: TM2; pfam05154 926556008613 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 926556008614 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 926556008615 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 926556008616 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 926556008617 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 926556008618 Peptidase family M28; Region: Peptidase_M28; pfam04389 926556008619 metal binding site [ion binding]; metal-binding site 926556008620 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 926556008621 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 926556008622 active site 926556008623 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556008624 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556008625 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 926556008626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556008627 Helix-turn-helix domain; Region: HTH_18; pfam12833 926556008628 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 926556008629 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 926556008630 DNA binding site [nucleotide binding] 926556008631 active site 926556008632 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926556008633 active site residue [active] 926556008634 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926556008635 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 926556008636 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 926556008637 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 926556008638 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 926556008639 active site 926556008640 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926556008641 NifU-like domain; Region: NifU; pfam01106 926556008642 antiporter inner membrane protein; Provisional; Region: PRK11670 926556008643 Domain of unknown function DUF59; Region: DUF59; pfam01883 926556008644 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 926556008645 Walker A motif; other site 926556008646 DNA primase, catalytic core; Region: dnaG; TIGR01391 926556008647 CHC2 zinc finger; Region: zf-CHC2; pfam01807 926556008648 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 926556008649 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 926556008650 active site 926556008651 metal binding site [ion binding]; metal-binding site 926556008652 interdomain interaction site; other site 926556008653 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 926556008654 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 926556008655 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 926556008656 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 926556008657 dimerization interface [polypeptide binding]; other site 926556008658 active site 926556008659 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 926556008660 Family of unknown function (DUF706); Region: DUF706; pfam05153 926556008661 Fasciclin domain; Region: Fasciclin; cl02663 926556008662 Fasciclin domain; Region: Fasciclin; cl02663 926556008663 Fasciclin domain; Region: Fasciclin; cl02663 926556008664 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556008665 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556008666 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556008667 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556008668 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556008669 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556008670 Fasciclin domain; Region: Fasciclin; pfam02469 926556008671 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts; Region: FAS1; smart00554 926556008672 Fasciclin domain; Region: Fasciclin; pfam02469 926556008673 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556008674 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556008675 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556008676 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556008677 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556008678 Pectate lyase; Region: Pec_lyase_C; cl01593 926556008679 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 926556008680 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 926556008681 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 926556008682 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 926556008683 Pectate lyase; Region: Pec_lyase_C; cl01593 926556008684 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926556008685 Interdomain contacts; other site 926556008686 Cytokine receptor motif; other site 926556008687 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 926556008688 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926556008689 Cellulose binding domain; Region: CBM_3; smart01067 926556008690 Cellulose binding domain; Region: CBM_3; pfam00942 926556008691 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926556008692 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 926556008693 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556008694 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 926556008695 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 926556008696 N-terminal plug; other site 926556008697 ligand-binding site [chemical binding]; other site 926556008698 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 926556008699 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556008700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556008701 dimer interface [polypeptide binding]; other site 926556008702 phosphorylation site [posttranslational modification] 926556008703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556008704 ATP binding site [chemical binding]; other site 926556008705 Mg2+ binding site [ion binding]; other site 926556008706 G-X-G motif; other site 926556008707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556008708 Response regulator receiver domain; Region: Response_reg; pfam00072 926556008709 active site 926556008710 phosphorylation site [posttranslational modification] 926556008711 intermolecular recognition site; other site 926556008712 dimerization interface [polypeptide binding]; other site 926556008713 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556008714 Sulfatase; Region: Sulfatase; pfam00884 926556008715 PA14 domain; Region: PA14; cl08459 926556008716 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 926556008717 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 926556008718 homodimer interface [polypeptide binding]; other site 926556008719 substrate-cofactor binding pocket; other site 926556008720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556008721 catalytic residue [active] 926556008722 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556008723 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556008724 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556008725 DNA binding residues [nucleotide binding] 926556008726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 926556008727 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 926556008728 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 926556008729 putative dimerization interface [polypeptide binding]; other site 926556008730 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 926556008731 putative ligand binding site [chemical binding]; other site 926556008732 Helix-turn-helix domain; Region: HTH_18; pfam12833 926556008733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556008734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556008735 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 926556008736 putative substrate translocation pore; other site 926556008737 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 926556008738 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926556008739 nucleotide binding site [chemical binding]; other site 926556008740 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 926556008741 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556008742 FecR protein; Region: FecR; pfam04773 926556008743 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556008744 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556008745 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556008746 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 926556008747 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556008748 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556008749 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 926556008750 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 926556008751 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 926556008752 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 926556008753 active site 926556008754 dimer interface [polypeptide binding]; other site 926556008755 motif 1; other site 926556008756 motif 2; other site 926556008757 motif 3; other site 926556008758 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 926556008759 anticodon binding site; other site 926556008760 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 926556008761 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 926556008762 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 926556008763 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 926556008764 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 926556008765 23S rRNA binding site [nucleotide binding]; other site 926556008766 L21 binding site [polypeptide binding]; other site 926556008767 L13 binding site [polypeptide binding]; other site 926556008768 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 926556008769 GIY-YIG motif/motif A; other site 926556008770 putative active site [active] 926556008771 putative metal binding site [ion binding]; other site 926556008772 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 926556008773 hydrophobic ligand binding site; other site 926556008774 Predicted permeases [General function prediction only]; Region: COG0795 926556008775 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 926556008776 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 926556008777 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 926556008778 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 926556008779 16S/18S rRNA binding site [nucleotide binding]; other site 926556008780 S13e-L30e interaction site [polypeptide binding]; other site 926556008781 25S rRNA binding site [nucleotide binding]; other site 926556008782 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 926556008783 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 926556008784 RNase E interface [polypeptide binding]; other site 926556008785 trimer interface [polypeptide binding]; other site 926556008786 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 926556008787 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 926556008788 RNase E interface [polypeptide binding]; other site 926556008789 trimer interface [polypeptide binding]; other site 926556008790 active site 926556008791 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 926556008792 putative nucleic acid binding region [nucleotide binding]; other site 926556008793 G-X-X-G motif; other site 926556008794 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 926556008795 RNA binding site [nucleotide binding]; other site 926556008796 domain interface; other site 926556008797 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 926556008798 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 926556008799 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556008800 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 926556008801 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556008802 DNA binding residues [nucleotide binding] 926556008803 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 926556008804 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926556008805 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 926556008806 Peptidase family M23; Region: Peptidase_M23; pfam01551 926556008807 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926556008808 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 926556008809 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 926556008810 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 926556008811 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 926556008812 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 926556008813 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 926556008814 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 926556008815 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 926556008816 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 926556008817 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 926556008818 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 926556008819 NIPSNAP; Region: NIPSNAP; pfam07978 926556008820 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 926556008821 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926556008822 ATP binding site [chemical binding]; other site 926556008823 putative Mg++ binding site [ion binding]; other site 926556008824 helicase superfamily c-terminal domain; Region: HELICc; smart00490 926556008825 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 926556008826 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 926556008827 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 926556008828 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 926556008829 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 926556008830 CsbD-like; Region: CsbD; pfam05532 926556008831 MG2 domain; Region: A2M_N; pfam01835 926556008832 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 926556008833 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556008834 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556008835 Alpha-2-macroglobulin family; Region: A2M; pfam00207 926556008836 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 926556008837 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 926556008838 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 926556008839 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 926556008840 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 926556008841 Na binding site [ion binding]; other site 926556008842 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 926556008843 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 926556008844 active site 926556008845 DNA binding site [nucleotide binding] 926556008846 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 926556008847 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 926556008848 putative ligand binding site [chemical binding]; other site 926556008849 NAD binding site [chemical binding]; other site 926556008850 dimerization interface [polypeptide binding]; other site 926556008851 catalytic site [active] 926556008852 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926556008853 Ligand Binding Site [chemical binding]; other site 926556008854 Tetratricopeptide repeat; Region: TPR_16; pfam13432 926556008855 TPR repeat; Region: TPR_11; pfam13414 926556008856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556008857 TPR motif; other site 926556008858 binding surface 926556008859 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926556008860 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 926556008861 DNA polymerase III, delta subunit; Region: holA; TIGR01128 926556008862 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 926556008863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556008864 binding surface 926556008865 TPR motif; other site 926556008866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556008867 binding surface 926556008868 TPR motif; other site 926556008869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556008870 binding surface 926556008871 TPR motif; other site 926556008872 Outer membrane lipoprotein; Region: YfiO; pfam13525 926556008873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 926556008874 binding surface 926556008875 TPR motif; other site 926556008876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 926556008877 binding surface 926556008878 TPR motif; other site 926556008879 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556008880 Sporulation related domain; Region: SPOR; pfam05036 926556008881 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 926556008882 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 926556008883 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 926556008884 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926556008885 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 926556008886 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556008887 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556008888 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556008889 DNA binding residues [nucleotide binding] 926556008890 FecR protein; Region: FecR; pfam04773 926556008891 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556008892 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556008893 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556008894 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556008895 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556008896 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556008897 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 926556008898 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 926556008899 NHL repeat; Region: NHL; pfam01436 926556008900 NHL repeat; Region: NHL; pfam01436 926556008901 NHL repeat; Region: NHL; pfam01436 926556008902 NHL repeat; Region: NHL; pfam01436 926556008903 NHL repeat; Region: NHL; pfam01436 926556008904 Predicted periplasmic protein [Function unknown]; Region: COG3698 926556008905 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 926556008906 NHL repeat; Region: NHL; pfam01436 926556008907 NHL repeat; Region: NHL; pfam01436 926556008908 NHL repeat; Region: NHL; pfam01436 926556008909 NHL repeat; Region: NHL; pfam01436 926556008910 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 926556008911 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 926556008912 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 926556008913 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926556008914 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926556008915 DNA binding site [nucleotide binding] 926556008916 domain linker motif; other site 926556008917 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 926556008918 dimerization interface [polypeptide binding]; other site 926556008919 ligand binding site [chemical binding]; other site 926556008920 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 926556008921 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 926556008922 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 926556008923 putative transporter; Provisional; Region: PRK10484 926556008924 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 926556008925 Na binding site [ion binding]; other site 926556008926 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556008927 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556008928 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556008929 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556008930 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556008931 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556008932 SusD family; Region: SusD; pfam07980 926556008933 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926556008934 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556008935 catalytic residues [active] 926556008936 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 926556008937 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926556008938 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926556008939 ligand binding site [chemical binding]; other site 926556008940 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 926556008941 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 926556008942 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 926556008943 trmE is a tRNA modification GTPase; Region: trmE; cd04164 926556008944 G1 box; other site 926556008945 GTP/Mg2+ binding site [chemical binding]; other site 926556008946 Switch I region; other site 926556008947 G2 box; other site 926556008948 Switch II region; other site 926556008949 G3 box; other site 926556008950 G4 box; other site 926556008951 G5 box; other site 926556008952 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 926556008953 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 926556008954 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926556008955 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 926556008956 active site 926556008957 DNA binding site [nucleotide binding] 926556008958 Int/Topo IB signature motif; other site 926556008959 Helix-turn-helix domain; Region: HTH_17; pfam12728 926556008960 Virulence-associated protein E; Region: VirE; pfam05272 926556008961 CHC2 zinc finger; Region: zf-CHC2; cl17510 926556008962 Toprim-like; Region: Toprim_2; pfam13155 926556008963 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 926556008964 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 926556008965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556008966 non-specific DNA binding site [nucleotide binding]; other site 926556008967 salt bridge; other site 926556008968 sequence-specific DNA binding site [nucleotide binding]; other site 926556008969 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 926556008970 Methyltransferase domain; Region: Methyltransf_23; pfam13489 926556008971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556008972 S-adenosylmethionine binding site [chemical binding]; other site 926556008973 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 926556008974 putative catalytic site [active] 926556008975 putative metal binding site [ion binding]; other site 926556008976 putative phosphate binding site [ion binding]; other site 926556008977 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 926556008978 putative catalytic site [active] 926556008979 putative metal binding site [ion binding]; other site 926556008980 putative phosphate binding site [ion binding]; other site 926556008981 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556008982 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556008983 SusD family; Region: SusD; pfam07980 926556008984 Secretin and TonB N terminus short domain; Region: STN; pfam07660 926556008985 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556008986 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556008987 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556008988 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556008989 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556008990 FecR protein; Region: FecR; pfam04773 926556008991 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556008992 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556008993 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556008994 DNA binding residues [nucleotide binding] 926556008995 Erythromycin esterase; Region: Erythro_esteras; cl17110 926556008996 Erythromycin esterase; Region: Erythro_esteras; pfam05139 926556008997 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926556008998 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926556008999 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556009000 catalytic residues [active] 926556009001 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 926556009002 pentamer interface [polypeptide binding]; other site 926556009003 dodecaamer interface [polypeptide binding]; other site 926556009004 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 926556009005 active site 926556009006 dimer interface [polypeptide binding]; other site 926556009007 magnesium binding site [ion binding]; other site 926556009008 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 926556009009 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 926556009010 tetramer interface [polypeptide binding]; other site 926556009011 active site 926556009012 Helix-turn-helix domain; Region: HTH_18; pfam12833 926556009013 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556009014 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 926556009015 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 926556009016 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 926556009017 intracellular protease, PfpI family; Region: PfpI; TIGR01382 926556009018 proposed catalytic triad [active] 926556009019 conserved cys residue [active] 926556009020 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 926556009021 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 926556009022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556009023 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556009024 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556009025 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556009026 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556009027 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556009028 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 926556009029 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 926556009030 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926556009031 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 926556009032 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 926556009033 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 926556009034 ABC-ATPase subunit interface; other site 926556009035 dimer interface [polypeptide binding]; other site 926556009036 putative PBP binding regions; other site 926556009037 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 926556009038 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 926556009039 ABC-ATPase subunit interface; other site 926556009040 dimer interface [polypeptide binding]; other site 926556009041 putative PBP binding regions; other site 926556009042 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 926556009043 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 926556009044 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 926556009045 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 926556009046 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 926556009047 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 926556009048 intersubunit interface [polypeptide binding]; other site 926556009049 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 926556009050 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 926556009051 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 926556009052 FeoA domain; Region: FeoA; pfam04023 926556009053 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556009054 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926556009055 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 926556009056 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 926556009057 trimer interface [polypeptide binding]; other site 926556009058 active site 926556009059 substrate binding site [chemical binding]; other site 926556009060 CoA binding site [chemical binding]; other site 926556009061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556009062 TPR motif; other site 926556009063 binding surface 926556009064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556009065 TPR motif; other site 926556009066 TPR repeat; Region: TPR_11; pfam13414 926556009067 binding surface 926556009068 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 926556009069 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 926556009070 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 926556009071 transmembrane helices; other site 926556009072 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 926556009073 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 926556009074 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 926556009075 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556009076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 926556009077 dimer interface [polypeptide binding]; other site 926556009078 phosphorylation site [posttranslational modification] 926556009079 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 926556009080 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926556009081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556009082 active site 926556009083 phosphorylation site [posttranslational modification] 926556009084 intermolecular recognition site; other site 926556009085 dimerization interface [polypeptide binding]; other site 926556009086 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926556009087 DNA binding site [nucleotide binding] 926556009088 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 926556009089 heme-binding site [chemical binding]; other site 926556009090 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 926556009091 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926556009092 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926556009093 active site 926556009094 catalytic tetrad [active] 926556009095 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 926556009096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926556009097 FeS/SAM binding site; other site 926556009098 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 926556009099 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 926556009100 ThiS interaction site; other site 926556009101 putative active site [active] 926556009102 tetramer interface [polypeptide binding]; other site 926556009103 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 926556009104 thiamine phosphate binding site [chemical binding]; other site 926556009105 active site 926556009106 pyrophosphate binding site [ion binding]; other site 926556009107 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 926556009108 thiamine phosphate binding site [chemical binding]; other site 926556009109 active site 926556009110 pyrophosphate binding site [ion binding]; other site 926556009111 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 926556009112 ThiC-associated domain; Region: ThiC-associated; pfam13667 926556009113 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 926556009114 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 926556009115 thiS-thiF/thiG interaction site; other site 926556009116 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 926556009117 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 926556009118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 926556009119 TPR motif; other site 926556009120 binding surface 926556009121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556009122 Tetratricopeptide repeat; Region: TPR_16; pfam13432 926556009123 TPR motif; other site 926556009124 binding surface 926556009125 DNA gyrase subunit A; Validated; Region: PRK05560 926556009126 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 926556009127 CAP-like domain; other site 926556009128 active site 926556009129 primary dimer interface [polypeptide binding]; other site 926556009130 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926556009131 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926556009132 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926556009133 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926556009134 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926556009135 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926556009136 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 926556009137 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 926556009138 substrate binding site [chemical binding]; other site 926556009139 hexamer interface [polypeptide binding]; other site 926556009140 metal binding site [ion binding]; metal-binding site 926556009141 Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493 926556009142 active site 926556009143 catalytic triad [active] 926556009144 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926556009145 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 926556009146 phosphate binding site [ion binding]; other site 926556009147 Electron transfer DM13; Region: DM13; pfam10517 926556009148 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 926556009149 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 926556009150 Walker B motif; other site 926556009151 arginine finger; other site 926556009152 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 926556009153 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 926556009154 TPR repeat; Region: TPR_11; pfam13414 926556009155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556009156 binding surface 926556009157 TPR motif; other site 926556009158 TPR repeat; Region: TPR_11; pfam13414 926556009159 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556009160 binding surface 926556009161 TPR motif; other site 926556009162 Tetratricopeptide repeat; Region: TPR_16; pfam13432 926556009163 TPR repeat; Region: TPR_11; pfam13414 926556009164 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556009165 binding surface 926556009166 TPR motif; other site 926556009167 TPR repeat; Region: TPR_11; pfam13414 926556009168 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 926556009169 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 926556009170 active site 926556009171 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 926556009172 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 926556009173 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926556009174 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 926556009175 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 926556009176 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 926556009177 PAAR motif; Region: PAAR_motif; pfam05488 926556009178 Phage protein D [General function prediction only]; Region: COG3500 926556009179 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 926556009180 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 926556009181 Sybindin-like family; Region: Sybindin; cl17582 926556009182 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 926556009183 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 926556009184 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 926556009185 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 926556009186 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 926556009187 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 926556009188 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 926556009189 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 926556009190 ATP binding site [chemical binding]; other site 926556009191 Mg++ binding site [ion binding]; other site 926556009192 motif III; other site 926556009193 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926556009194 nucleotide binding region [chemical binding]; other site 926556009195 ATP-binding site [chemical binding]; other site 926556009196 The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633 926556009197 methionine sulfoxide reductase A; Provisional; Region: PRK14054 926556009198 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 926556009199 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 926556009200 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926556009201 FeS/SAM binding site; other site 926556009202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 926556009203 Sulfatase; Region: Sulfatase; cl17466 926556009204 Uncharacterized protein family UPF0565; Region: UPF0565; pfam10561 926556009205 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556009206 binding surface 926556009207 Tetratricopeptide repeat; Region: TPR_16; pfam13432 926556009208 TPR motif; other site 926556009209 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926556009210 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 926556009211 DXD motif; other site 926556009212 Response regulator receiver domain; Region: Response_reg; pfam00072 926556009213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556009214 active site 926556009215 phosphorylation site [posttranslational modification] 926556009216 intermolecular recognition site; other site 926556009217 dimerization interface [polypeptide binding]; other site 926556009218 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926556009219 active site 926556009220 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 926556009221 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 926556009222 active site 926556009223 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 926556009224 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926556009225 active site 926556009226 Bacterial SH3 domain; Region: SH3_3; cl17532 926556009227 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 926556009228 NlpC/P60 family; Region: NLPC_P60; pfam00877 926556009229 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 926556009230 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 926556009231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 926556009232 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 926556009233 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 926556009234 HlyD family secretion protein; Region: HlyD_2; pfam12700 926556009235 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556009236 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 926556009237 Outer membrane efflux protein; Region: OEP; pfam02321 926556009238 Outer membrane efflux protein; Region: OEP; pfam02321 926556009239 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 926556009240 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 926556009241 active site 926556009242 catalytic site [active] 926556009243 Surface antigen; Region: Bac_surface_Ag; pfam01103 926556009244 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 926556009245 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 926556009246 active site 926556009247 DctM-like transporters; Region: DctM; pfam06808 926556009248 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 926556009249 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 926556009250 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 926556009251 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 926556009252 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 926556009253 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 926556009254 active site 926556009255 intersubunit interface [polypeptide binding]; other site 926556009256 catalytic residue [active] 926556009257 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 926556009258 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 926556009259 substrate binding site [chemical binding]; other site 926556009260 ATP binding site [chemical binding]; other site 926556009261 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 926556009262 galactarate dehydratase; Region: galactar-dH20; TIGR03248 926556009263 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 926556009264 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 926556009265 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 926556009266 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556009267 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556009268 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556009269 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556009270 Uncharacterized conserved protein [Function unknown]; Region: COG1262 926556009271 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 926556009272 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 926556009273 FAD binding site [chemical binding]; other site 926556009274 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 926556009275 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 926556009276 substrate binding pocket [chemical binding]; other site 926556009277 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 926556009278 B12 binding site [chemical binding]; other site 926556009279 cobalt ligand [ion binding]; other site 926556009280 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 926556009281 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 926556009282 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 926556009283 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 926556009284 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 926556009285 dimer interface [polypeptide binding]; other site 926556009286 [2Fe-2S] cluster binding site [ion binding]; other site 926556009287 Protein of unknown function (DUF819); Region: DUF819; cl02317 926556009288 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 926556009289 putative active site [active] 926556009290 putative CoA binding site [chemical binding]; other site 926556009291 nudix motif; other site 926556009292 metal binding site [ion binding]; metal-binding site 926556009293 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 926556009294 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315 926556009295 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 926556009296 PAS fold; Region: PAS_3; pfam08447 926556009297 PAS domain S-box; Region: sensory_box; TIGR00229 926556009298 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556009299 putative active site [active] 926556009300 heme pocket [chemical binding]; other site 926556009301 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 926556009302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556009303 putative active site [active] 926556009304 heme pocket [chemical binding]; other site 926556009305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556009306 dimer interface [polypeptide binding]; other site 926556009307 phosphorylation site [posttranslational modification] 926556009308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556009309 ATP binding site [chemical binding]; other site 926556009310 Mg2+ binding site [ion binding]; other site 926556009311 G-X-G motif; other site 926556009312 Response regulator receiver domain; Region: Response_reg; pfam00072 926556009313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556009314 active site 926556009315 phosphorylation site [posttranslational modification] 926556009316 intermolecular recognition site; other site 926556009317 dimerization interface [polypeptide binding]; other site 926556009318 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926556009319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556009320 active site 926556009321 phosphorylation site [posttranslational modification] 926556009322 intermolecular recognition site; other site 926556009323 dimerization interface [polypeptide binding]; other site 926556009324 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 926556009325 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 926556009326 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 926556009327 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 926556009328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926556009329 dimer interface [polypeptide binding]; other site 926556009330 conserved gate region; other site 926556009331 putative PBP binding loops; other site 926556009332 ABC-ATPase subunit interface; other site 926556009333 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 926556009334 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 926556009335 Walker A/P-loop; other site 926556009336 ATP binding site [chemical binding]; other site 926556009337 Q-loop/lid; other site 926556009338 ABC transporter signature motif; other site 926556009339 Walker B; other site 926556009340 D-loop; other site 926556009341 H-loop/switch region; other site 926556009342 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 926556009343 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 926556009344 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556009345 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556009346 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556009347 DNA binding residues [nucleotide binding] 926556009348 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556009349 FecR protein; Region: FecR; pfam04773 926556009350 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556009351 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 926556009352 nudix motif; other site 926556009353 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 926556009354 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 926556009355 RDD family; Region: RDD; pfam06271 926556009356 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 926556009357 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 926556009358 conserved repeat domain; Region: B_ant_repeat; TIGR01451 926556009359 Domain of unknown function DUF11; Region: DUF11; pfam01345 926556009360 Domain of unknown function DUF11; Region: DUF11; pfam01345 926556009361 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926556009362 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 926556009363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 926556009364 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 926556009365 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926556009366 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 926556009367 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 926556009368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 926556009369 Helix-turn-helix domain; Region: HTH_18; pfam12833 926556009370 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556009371 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 926556009372 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926556009373 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 926556009374 Beta-lactamase; Region: Beta-lactamase; pfam00144 926556009375 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 926556009376 Beta/Gamma crystallin; Region: Crystall; cl02528 926556009377 Beta/Gamma crystallin; Region: Crystall; cl02528 926556009378 maltose O-acetyltransferase; Provisional; Region: PRK10092 926556009379 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 926556009380 active site 926556009381 substrate binding site [chemical binding]; other site 926556009382 trimer interface [polypeptide binding]; other site 926556009383 CoA binding site [chemical binding]; other site 926556009384 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926556009385 dimerization interface [polypeptide binding]; other site 926556009386 putative DNA binding site [nucleotide binding]; other site 926556009387 putative Zn2+ binding site [ion binding]; other site 926556009388 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 926556009389 putative hydrophobic ligand binding site [chemical binding]; other site 926556009390 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 926556009391 gliding motility-associated protein GldC; Region: GldC; TIGR03515 926556009392 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556009393 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556009394 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556009395 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 926556009396 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 926556009397 Sulfatase; Region: Sulfatase; cl17466 926556009398 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556009399 Sulfatase; Region: Sulfatase; cl17466 926556009400 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556009401 intracellular protease, PfpI family; Region: PfpI; TIGR01382 926556009402 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 926556009403 conserved cys residue [active] 926556009404 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 926556009405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926556009406 NAD(P) binding site [chemical binding]; other site 926556009407 active site 926556009408 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 926556009409 Receptor L domain; Region: Recep_L_domain; pfam01030 926556009410 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 926556009411 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 926556009412 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 926556009413 putative acyl-acceptor binding pocket; other site 926556009414 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 926556009415 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556009416 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926556009417 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556009418 von Willebrand factor type A domain; Region: VWA_2; pfam13519 926556009419 metal ion-dependent adhesion site (MIDAS); other site 926556009420 acetyl-CoA C-acetyltransferase; Region: PLN02644 926556009421 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 926556009422 dimer interface [polypeptide binding]; other site 926556009423 active site 926556009424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 926556009425 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 926556009426 ATP binding site [chemical binding]; other site 926556009427 active site 926556009428 substrate binding site [chemical binding]; other site 926556009429 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 926556009430 anti sigma factor interaction site; other site 926556009431 regulatory phosphorylation site [posttranslational modification]; other site 926556009432 ribonuclease Z; Region: RNase_Z; TIGR02651 926556009433 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 926556009434 CAAX protease self-immunity; Region: Abi; pfam02517 926556009435 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926556009436 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 926556009437 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 926556009438 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 926556009439 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 926556009440 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 926556009441 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 926556009442 Surface antigen; Region: Bac_surface_Ag; pfam01103 926556009443 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 926556009444 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 926556009445 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 926556009446 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 926556009447 active site 926556009448 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 926556009449 Lumazine binding domain; Region: Lum_binding; pfam00677 926556009450 Lumazine binding domain; Region: Lum_binding; pfam00677 926556009451 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 926556009452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556009453 S-adenosylmethionine binding site [chemical binding]; other site 926556009454 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 926556009455 integral membrane protein; Region: integ_memb_HG; TIGR03954 926556009456 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 926556009457 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 926556009458 dimerization interface [polypeptide binding]; other site 926556009459 DPS ferroxidase diiron center [ion binding]; other site 926556009460 ion pore; other site 926556009461 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 926556009462 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 926556009463 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 926556009464 DNA-binding site [nucleotide binding]; DNA binding site 926556009465 RNA-binding motif; other site 926556009466 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 926556009467 active site 926556009468 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 926556009469 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 926556009470 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 926556009471 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556009472 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556009473 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556009474 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556009475 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 926556009476 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 926556009477 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 926556009478 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 926556009479 NAD(P) binding site [chemical binding]; other site 926556009480 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926556009481 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926556009482 Amidohydrolase; Region: Amidohydro_4; pfam13147 926556009483 active site 926556009484 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 926556009485 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 926556009486 active site 926556009487 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 926556009488 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 926556009489 LytTr DNA-binding domain; Region: LytTR; smart00850 926556009490 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 926556009491 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926556009492 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926556009493 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 926556009494 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556009495 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 926556009496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926556009497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926556009498 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926556009499 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926556009500 active site 926556009501 catalytic tetrad [active] 926556009502 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 926556009503 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 926556009504 Family description; Region: VCBS; pfam13517 926556009505 Family description; Region: VCBS; pfam13517 926556009506 Family description; Region: VCBS; pfam13517 926556009507 Family description; Region: VCBS; pfam13517 926556009508 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 926556009509 Family description; Region: VCBS; pfam13517 926556009510 Family description; Region: VCBS; pfam13517 926556009511 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556009512 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556009513 SusD family; Region: SusD; pfam07980 926556009514 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556009515 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556009516 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556009517 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556009518 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 926556009519 Two component regulator propeller; Region: Reg_prop; pfam07494 926556009520 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 926556009521 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556009522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556009523 dimer interface [polypeptide binding]; other site 926556009524 phosphorylation site [posttranslational modification] 926556009525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556009526 ATP binding site [chemical binding]; other site 926556009527 Mg2+ binding site [ion binding]; other site 926556009528 G-X-G motif; other site 926556009529 Response regulator receiver domain; Region: Response_reg; pfam00072 926556009530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556009531 active site 926556009532 phosphorylation site [posttranslational modification] 926556009533 intermolecular recognition site; other site 926556009534 dimerization interface [polypeptide binding]; other site 926556009535 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 926556009536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556009537 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 926556009538 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 926556009539 N-terminal plug; other site 926556009540 ligand-binding site [chemical binding]; other site 926556009541 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 926556009542 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 926556009543 homotrimer interface [polypeptide binding]; other site 926556009544 Walker A motif; other site 926556009545 GTP binding site [chemical binding]; other site 926556009546 Walker B motif; other site 926556009547 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 926556009548 Ligand Binding Site [chemical binding]; other site 926556009549 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 926556009550 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 926556009551 putative dimer interface [polypeptide binding]; other site 926556009552 active site pocket [active] 926556009553 putative cataytic base [active] 926556009554 cobalamin synthase; Reviewed; Region: cobS; PRK00235 926556009555 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 926556009556 catalytic core [active] 926556009557 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 926556009558 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 926556009559 Walker A/P-loop; other site 926556009560 ATP binding site [chemical binding]; other site 926556009561 Q-loop/lid; other site 926556009562 ABC transporter signature motif; other site 926556009563 Walker B; other site 926556009564 D-loop; other site 926556009565 H-loop/switch region; other site 926556009566 Predicted transcriptional regulators [Transcription]; Region: COG1725 926556009567 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 926556009568 DNA-binding site [nucleotide binding]; DNA binding site 926556009569 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 926556009570 Strictosidine synthase; Region: Str_synth; pfam03088 926556009571 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 926556009572 fructuronate transporter; Provisional; Region: PRK10034; cl15264 926556009573 galactonate dehydratase; Provisional; Region: PRK14017 926556009574 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 926556009575 putative active site pocket [active] 926556009576 putative metal binding site [ion binding]; other site 926556009577 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 926556009578 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 926556009579 active site 926556009580 intersubunit interface [polypeptide binding]; other site 926556009581 catalytic residue [active] 926556009582 Transcriptional regulators [Transcription]; Region: FadR; COG2186 926556009583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 926556009584 DNA-binding site [nucleotide binding]; DNA binding site 926556009585 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 926556009586 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556009587 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 926556009588 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 926556009589 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 926556009590 HPP family; Region: HPP; pfam04982 926556009591 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556009592 Sulfatase; Region: Sulfatase; pfam00884 926556009593 Sulfatase; Region: Sulfatase; cl17466 926556009594 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556009595 Glycosyl hydrolase family 43; Region: GH43_7; cd08986 926556009596 active site 926556009597 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556009598 Sulfatase; Region: Sulfatase; pfam00884 926556009599 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556009600 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556009601 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556009602 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556009603 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556009604 FecR protein; Region: FecR; pfam04773 926556009605 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556009606 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926556009607 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556009608 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 926556009609 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 926556009610 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 926556009611 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 926556009612 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 926556009613 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 926556009614 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 926556009615 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 926556009616 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 926556009617 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 926556009618 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556009619 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926556009620 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 926556009621 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 926556009622 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 926556009623 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 926556009624 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926556009625 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556009626 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556009627 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926556009628 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 926556009629 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 926556009630 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 926556009631 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 926556009632 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 926556009633 Substrate binding site; other site 926556009634 Cupin domain; Region: Cupin_2; cl17218 926556009635 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926556009636 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 926556009637 NAD binding site [chemical binding]; other site 926556009638 putative substrate binding site 2 [chemical binding]; other site 926556009639 putative substrate binding site 1 [chemical binding]; other site 926556009640 active site 926556009641 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 926556009642 Chain length determinant protein; Region: Wzz; pfam02706 926556009643 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 926556009644 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 926556009645 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 926556009646 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 926556009647 Response regulator receiver domain; Region: Response_reg; pfam00072 926556009648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556009649 active site 926556009650 phosphorylation site [posttranslational modification] 926556009651 intermolecular recognition site; other site 926556009652 dimerization interface [polypeptide binding]; other site 926556009653 LytTr DNA-binding domain; Region: LytTR; smart00850 926556009654 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926556009655 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 926556009656 putative NAD(P) binding site [chemical binding]; other site 926556009657 active site 926556009658 putative substrate binding site [chemical binding]; other site 926556009659 Bacterial sugar transferase; Region: Bac_transf; pfam02397 926556009660 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 926556009661 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 926556009662 DNA topoisomerase III; Provisional; Region: PRK07726 926556009663 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 926556009664 active site 926556009665 putative interdomain interaction site [polypeptide binding]; other site 926556009666 putative metal-binding site [ion binding]; other site 926556009667 putative nucleotide binding site [chemical binding]; other site 926556009668 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 926556009669 domain I; other site 926556009670 DNA binding groove [nucleotide binding] 926556009671 phosphate binding site [ion binding]; other site 926556009672 domain II; other site 926556009673 domain III; other site 926556009674 nucleotide binding site [chemical binding]; other site 926556009675 catalytic site [active] 926556009676 domain IV; other site 926556009677 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 926556009678 Sulfatase; Region: Sulfatase; pfam00884 926556009679 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556009680 Sulfatase; Region: Sulfatase; cl17466 926556009681 Response regulator receiver domain; Region: Response_reg; pfam00072 926556009682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556009683 active site 926556009684 phosphorylation site [posttranslational modification] 926556009685 intermolecular recognition site; other site 926556009686 dimerization interface [polypeptide binding]; other site 926556009687 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926556009688 RNAP_Rpb7_N_like: This conserved domain represents the N-terminal ribonucleoprotein (RNP) domain of the Rpb7 subunit of eukaryotic RNA polymerase (RNAP) II and its homologs, Rpa43 of eukaryotic RNAP I, Rpc25 of eukaryotic RNAP III, and RpoE (subunit E)...; Region: RNAP_Rpb7_N_like; cl04309 926556009689 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 926556009690 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 926556009691 active site 926556009692 metal binding site [ion binding]; metal-binding site 926556009693 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 926556009694 dimer interface [polypeptide binding]; other site 926556009695 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 926556009696 putative hydrophobic ligand binding site [chemical binding]; other site 926556009697 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 926556009698 putative active site [active] 926556009699 catalytic site [active] 926556009700 putative metal binding site [ion binding]; other site 926556009701 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556009702 Sulfatase; Region: Sulfatase; pfam00884 926556009703 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 926556009704 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 926556009705 active site 926556009706 catalytic site [active] 926556009707 substrate binding site [chemical binding]; other site 926556009708 EcsC protein family; Region: EcsC; pfam12787 926556009709 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 926556009710 active site 926556009711 metal binding site [ion binding]; metal-binding site 926556009712 homotetramer interface [polypeptide binding]; other site 926556009713 Protein of unknown function (DUF808); Region: DUF808; cl01002 926556009714 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 926556009715 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 926556009716 NAD(P) binding site [chemical binding]; other site 926556009717 catalytic residues [active] 926556009718 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 926556009719 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 926556009720 alpha subunit interface [polypeptide binding]; other site 926556009721 TPP binding site [chemical binding]; other site 926556009722 heterodimer interface [polypeptide binding]; other site 926556009723 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 926556009724 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926556009725 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 926556009726 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556009727 Histidine kinase; Region: His_kinase; pfam06580 926556009728 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 926556009729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556009730 active site 926556009731 phosphorylation site [posttranslational modification] 926556009732 intermolecular recognition site; other site 926556009733 dimerization interface [polypeptide binding]; other site 926556009734 LytTr DNA-binding domain; Region: LytTR; smart00850 926556009735 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 926556009736 nucleoside/Zn binding site; other site 926556009737 dimer interface [polypeptide binding]; other site 926556009738 catalytic motif [active] 926556009739 tyrosine decarboxylase; Region: PLN02880 926556009740 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 926556009741 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926556009742 catalytic residue [active] 926556009743 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 926556009744 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 926556009745 active site 926556009746 catalytic residues [active] 926556009747 metal binding site [ion binding]; metal-binding site 926556009748 signal recognition particle protein; Provisional; Region: PRK10867 926556009749 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 926556009750 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 926556009751 P loop; other site 926556009752 GTP binding site [chemical binding]; other site 926556009753 Signal peptide binding domain; Region: SRP_SPB; pfam02978 926556009754 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 926556009755 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 926556009756 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926556009757 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 926556009758 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 926556009759 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 926556009760 Walker A/P-loop; other site 926556009761 ATP binding site [chemical binding]; other site 926556009762 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 926556009763 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 926556009764 ABC transporter signature motif; other site 926556009765 Walker B; other site 926556009766 D-loop; other site 926556009767 H-loop/switch region; other site 926556009768 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 926556009769 B12 binding site [chemical binding]; other site 926556009770 Radical SAM superfamily; Region: Radical_SAM; pfam04055 926556009771 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 926556009772 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 926556009773 catalytic residues [active] 926556009774 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 926556009775 Fic family protein [Function unknown]; Region: COG3177 926556009776 Fic/DOC family; Region: Fic; pfam02661 926556009777 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 926556009778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556009779 non-specific DNA binding site [nucleotide binding]; other site 926556009780 salt bridge; other site 926556009781 sequence-specific DNA binding site [nucleotide binding]; other site 926556009782 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 926556009783 argininosuccinate synthase; Provisional; Region: PRK13820 926556009784 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 926556009785 Ligand Binding Site [chemical binding]; other site 926556009786 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 926556009787 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 926556009788 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 926556009789 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 926556009790 inhibitor-cofactor binding pocket; inhibition site 926556009791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556009792 catalytic residue [active] 926556009793 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 926556009794 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 926556009795 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 926556009796 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 926556009797 nucleotide binding site [chemical binding]; other site 926556009798 N-acetyl-L-glutamate binding site [chemical binding]; other site 926556009799 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 926556009800 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 926556009801 metal binding site [ion binding]; metal-binding site 926556009802 dimer interface [polypeptide binding]; other site 926556009803 argininosuccinate lyase; Provisional; Region: PRK00855 926556009804 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 926556009805 active sites [active] 926556009806 tetramer interface [polypeptide binding]; other site 926556009807 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 926556009808 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 926556009809 DNA binding residues [nucleotide binding] 926556009810 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 926556009811 DNA protecting protein DprA; Region: dprA; TIGR00732 926556009812 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 926556009813 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 926556009814 active site 926556009815 catalytic residues [active] 926556009816 metal binding site [ion binding]; metal-binding site 926556009817 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 926556009818 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 926556009819 Methyltransferase domain; Region: Methyltransf_31; pfam13847 926556009820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556009821 S-adenosylmethionine binding site [chemical binding]; other site 926556009822 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 926556009823 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926556009824 active site 926556009825 Methyltransferase domain; Region: Methyltransf_24; pfam13578 926556009826 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 926556009827 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 926556009828 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 926556009829 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 926556009830 inhibitor-cofactor binding pocket; inhibition site 926556009831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556009832 catalytic residue [active] 926556009833 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 926556009834 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556009835 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 926556009836 putative ADP-binding pocket [chemical binding]; other site 926556009837 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556009838 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 926556009839 FAD binding domain; Region: FAD_binding_4; pfam01565 926556009840 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 926556009841 Predicted membrane protein [Function unknown]; Region: COG4325 926556009842 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 926556009843 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 926556009844 dimer interface [polypeptide binding]; other site 926556009845 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926556009846 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556009847 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 926556009848 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 926556009849 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 926556009850 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 926556009851 SnoaL-like domain; Region: SnoaL_2; pfam12680 926556009852 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 926556009853 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 926556009854 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 926556009855 aspartate racemase; Region: asp_race; TIGR00035 926556009856 Cation efflux family; Region: Cation_efflux; pfam01545 926556009857 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 926556009858 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 926556009859 dimer interface [polypeptide binding]; other site 926556009860 ssDNA binding site [nucleotide binding]; other site 926556009861 tetramer (dimer of dimers) interface [polypeptide binding]; other site 926556009862 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 926556009863 active site clefts [active] 926556009864 zinc binding site [ion binding]; other site 926556009865 dimer interface [polypeptide binding]; other site 926556009866 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 926556009867 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 926556009868 Sulfate transporter family; Region: Sulfate_transp; pfam00916 926556009869 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926556009870 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926556009871 active site 926556009872 catalytic tetrad [active] 926556009873 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926556009874 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926556009875 active site 926556009876 catalytic tetrad [active] 926556009877 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 926556009878 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926556009879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556009880 binding surface 926556009881 TPR motif; other site 926556009882 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926556009883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556009884 dimer interface [polypeptide binding]; other site 926556009885 phosphorylation site [posttranslational modification] 926556009886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556009887 ATP binding site [chemical binding]; other site 926556009888 Mg2+ binding site [ion binding]; other site 926556009889 G-X-G motif; other site 926556009890 Response regulator receiver domain; Region: Response_reg; pfam00072 926556009891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556009892 active site 926556009893 phosphorylation site [posttranslational modification] 926556009894 intermolecular recognition site; other site 926556009895 dimerization interface [polypeptide binding]; other site 926556009896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556009897 Response regulator receiver domain; Region: Response_reg; pfam00072 926556009898 active site 926556009899 phosphorylation site [posttranslational modification] 926556009900 intermolecular recognition site; other site 926556009901 dimerization interface [polypeptide binding]; other site 926556009902 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 926556009903 active site 926556009904 HslU subunit interaction site [polypeptide binding]; other site 926556009905 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 926556009906 E3 interaction surface; other site 926556009907 lipoyl attachment site [posttranslational modification]; other site 926556009908 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 926556009909 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 926556009910 E3 interaction surface; other site 926556009911 lipoyl attachment site [posttranslational modification]; other site 926556009912 e3 binding domain; Region: E3_binding; pfam02817 926556009913 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 926556009914 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 926556009915 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 926556009916 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 926556009917 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 926556009918 dimer interface [polypeptide binding]; other site 926556009919 active site 926556009920 CoA binding pocket [chemical binding]; other site 926556009921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 926556009922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 926556009923 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 926556009924 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926556009925 nucleotide binding site [chemical binding]; other site 926556009926 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 926556009927 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 926556009928 active site 926556009929 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 926556009930 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 926556009931 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926556009932 nucleotide binding site [chemical binding]; other site 926556009933 Family description; Region: VCBS; pfam13517 926556009934 Family description; Region: VCBS; pfam13517 926556009935 Family description; Region: VCBS; pfam13517 926556009936 Family description; Region: VCBS; pfam13517 926556009937 Family description; Region: VCBS; pfam13517 926556009938 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 926556009939 Family description; Region: VCBS; pfam13517 926556009940 Family description; Region: VCBS; pfam13517 926556009941 Family description; Region: VCBS; pfam13517 926556009942 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 926556009943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 926556009944 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 926556009945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 926556009946 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 926556009947 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926556009948 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 926556009949 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926556009950 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556009951 catalytic residues [active] 926556009952 Cupin domain; Region: Cupin_2; cl17218 926556009953 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 926556009954 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 926556009955 L-fucose transporter; Provisional; Region: PRK10133; cl17665 926556009956 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 926556009957 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 926556009958 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926556009959 nucleotide binding site [chemical binding]; other site 926556009960 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 926556009961 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 926556009962 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556009963 SusD family; Region: SusD; pfam07980 926556009964 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556009965 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556009966 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556009967 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556009968 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926556009969 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926556009970 DNA binding site [nucleotide binding] 926556009971 domain linker motif; other site 926556009972 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 926556009973 dimerization interface [polypeptide binding]; other site 926556009974 ligand binding site [chemical binding]; other site 926556009975 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 926556009976 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556009977 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556009978 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556009979 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556009980 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556009981 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 926556009982 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556009983 SusD family; Region: SusD; pfam07980 926556009984 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556009985 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556009986 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556009987 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556009988 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556009989 FecR protein; Region: FecR; pfam04773 926556009990 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556009991 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556009992 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556009993 DNA binding residues [nucleotide binding] 926556009994 methionine sulfoxide reductase A; Provisional; Region: PRK14054 926556009995 methionine sulfoxide reductase B; Provisional; Region: PRK00222 926556009996 SelR domain; Region: SelR; pfam01641 926556009997 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 926556009998 NADH(P)-binding; Region: NAD_binding_10; pfam13460 926556009999 NAD(P) binding site [chemical binding]; other site 926556010000 putative active site [active] 926556010001 short chain dehydrogenase; Provisional; Region: PRK06500 926556010002 classical (c) SDRs; Region: SDR_c; cd05233 926556010003 NAD(P) binding site [chemical binding]; other site 926556010004 active site 926556010005 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926556010006 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926556010007 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 926556010008 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 926556010009 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 926556010010 active site 926556010011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 926556010012 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556010013 Sulfatase; Region: Sulfatase; pfam00884 926556010014 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 926556010015 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 926556010016 putative ligand binding site [chemical binding]; other site 926556010017 putative NAD binding site [chemical binding]; other site 926556010018 catalytic site [active] 926556010019 Histidine kinase; Region: His_kinase; pfam06580 926556010020 Response regulator receiver domain; Region: Response_reg; pfam00072 926556010021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556010022 active site 926556010023 phosphorylation site [posttranslational modification] 926556010024 intermolecular recognition site; other site 926556010025 dimerization interface [polypeptide binding]; other site 926556010026 LytTr DNA-binding domain; Region: LytTR; smart00850 926556010027 Pectate lyase; Region: Pec_lyase_C; cl01593 926556010028 Secretin and TonB N terminus short domain; Region: STN; smart00965 926556010029 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556010030 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556010031 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926556010032 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 926556010033 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 926556010034 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 926556010035 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 926556010036 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 926556010037 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 926556010038 hydroxyglutarate oxidase; Provisional; Region: PRK11728 926556010039 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 926556010040 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 926556010041 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 926556010042 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 926556010043 dimer interface [polypeptide binding]; other site 926556010044 NADP binding site [chemical binding]; other site 926556010045 catalytic residues [active] 926556010046 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 926556010047 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 926556010048 inhibitor site; inhibition site 926556010049 active site 926556010050 dimer interface [polypeptide binding]; other site 926556010051 catalytic residue [active] 926556010052 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 926556010053 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 926556010054 generic binding surface II; other site 926556010055 generic binding surface I; other site 926556010056 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 926556010057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926556010058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926556010059 Ligase N family; Region: LIGANc; smart00532 926556010060 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 926556010061 nucleotide binding pocket [chemical binding]; other site 926556010062 K-X-D-G motif; other site 926556010063 catalytic site [active] 926556010064 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 926556010065 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 926556010066 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 926556010067 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 926556010068 Dimer interface [polypeptide binding]; other site 926556010069 BRCT sequence motif; other site 926556010070 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 926556010071 dihydrodipicolinate synthase; Region: dapA; TIGR00674 926556010072 dimer interface [polypeptide binding]; other site 926556010073 active site 926556010074 catalytic residue [active] 926556010075 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 926556010076 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 926556010077 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926556010078 catalytic residue [active] 926556010079 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 926556010080 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 926556010081 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 926556010082 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 926556010083 Uncharacterized conserved protein [Function unknown]; Region: COG4198 926556010084 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 926556010085 Maf-like protein; Region: Maf; pfam02545 926556010086 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 926556010087 active site 926556010088 dimer interface [polypeptide binding]; other site 926556010089 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 926556010090 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 926556010091 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 926556010092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556010093 non-specific DNA binding site [nucleotide binding]; other site 926556010094 salt bridge; other site 926556010095 sequence-specific DNA binding site [nucleotide binding]; other site 926556010096 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 926556010097 Catalytic site [active] 926556010098 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556010099 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926556010100 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556010101 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 926556010102 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926556010103 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 926556010104 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 926556010105 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 926556010106 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 926556010107 RNA binding site [nucleotide binding]; other site 926556010108 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926556010109 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556010110 catalytic residues [active] 926556010111 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 926556010112 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556010113 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556010114 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556010115 DNA binding residues [nucleotide binding] 926556010116 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 926556010117 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 926556010118 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 926556010119 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926556010120 nucleotide binding site [chemical binding]; other site 926556010121 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 926556010122 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 926556010123 Uncharacterized conserved protein [Function unknown]; Region: COG3538 926556010124 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 926556010125 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 926556010126 SusE outer membrane protein; Region: SusE; pfam14292 926556010127 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556010128 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556010129 SusD family; Region: SusD; pfam07980 926556010130 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556010131 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556010132 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556010133 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556010134 FecR protein; Region: FecR; pfam04773 926556010135 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556010136 Uncharacterized conserved protein [Function unknown]; Region: COG2308 926556010137 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 926556010138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 926556010139 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 926556010140 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 926556010141 active site 926556010142 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 926556010143 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 926556010144 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 926556010145 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926556010146 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556010147 DNA binding residues [nucleotide binding] 926556010148 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556010149 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 926556010150 putative catalytic site [active] 926556010151 putative metal binding site [ion binding]; other site 926556010152 putative phosphate binding site [ion binding]; other site 926556010153 DinB family; Region: DinB; cl17821 926556010154 DinB superfamily; Region: DinB_2; pfam12867 926556010155 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 926556010156 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 926556010157 putative active site [active] 926556010158 metal binding site [ion binding]; metal-binding site 926556010159 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 926556010160 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 926556010161 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 926556010162 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 926556010163 NADP binding site [chemical binding]; other site 926556010164 homodimer interface [polypeptide binding]; other site 926556010165 active site 926556010166 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 926556010167 TQO small subunit DoxD; Region: DoxD; pfam04173 926556010168 TQO small subunit DoxA; Region: DoxA; pfam07680 926556010169 DsrE/DsrF-like family; Region: DrsE; pfam02635 926556010170 Na(+)-dependent inorganic phosphate cotransporter; Region: 2A0114euk; TIGR00894 926556010171 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 926556010172 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 926556010173 Cl- selectivity filter; other site 926556010174 Cl- binding residues [ion binding]; other site 926556010175 pore gating glutamate residue; other site 926556010176 dimer interface [polypeptide binding]; other site 926556010177 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 926556010178 Beta-lactamase; Region: Beta-lactamase; pfam00144 926556010179 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 926556010180 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926556010181 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556010182 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556010183 Sulfatase; Region: Sulfatase; pfam00884 926556010184 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 926556010185 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 926556010186 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926556010187 FeS/SAM binding site; other site 926556010188 HemN C-terminal domain; Region: HemN_C; pfam06969 926556010189 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 926556010190 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 926556010191 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 926556010192 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 926556010193 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556010194 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926556010195 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 926556010196 N-terminal plug; other site 926556010197 ligand-binding site [chemical binding]; other site 926556010198 Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526 926556010199 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 926556010200 Pirin; Region: Pirin; pfam02678 926556010201 Pirin-related protein [General function prediction only]; Region: COG1741 926556010202 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 926556010203 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 926556010204 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 926556010205 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 926556010206 gamma-glutamyl kinase; Provisional; Region: PRK05429 926556010207 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 926556010208 nucleotide binding site [chemical binding]; other site 926556010209 homotetrameric interface [polypeptide binding]; other site 926556010210 putative phosphate binding site [ion binding]; other site 926556010211 putative allosteric binding site; other site 926556010212 PUA domain; Region: PUA; pfam01472 926556010213 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 926556010214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556010215 Walker A/P-loop; other site 926556010216 ATP binding site [chemical binding]; other site 926556010217 Q-loop/lid; other site 926556010218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556010219 ABC transporter signature motif; other site 926556010220 Walker B; other site 926556010221 D-loop; other site 926556010222 H-loop/switch region; other site 926556010223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556010224 Q-loop/lid; other site 926556010225 ABC transporter signature motif; other site 926556010226 Walker B; other site 926556010227 D-loop; other site 926556010228 H-loop/switch region; other site 926556010229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556010230 Walker A/P-loop; other site 926556010231 ATP binding site [chemical binding]; other site 926556010232 Q-loop/lid; other site 926556010233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556010234 ABC transporter; Region: ABC_tran; pfam00005 926556010235 ABC transporter signature motif; other site 926556010236 Walker B; other site 926556010237 D-loop; other site 926556010238 H-loop/switch region; other site 926556010239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556010240 AAA domain; Region: AAA_21; pfam13304 926556010241 Walker A/P-loop; other site 926556010242 ATP binding site [chemical binding]; other site 926556010243 Q-loop/lid; other site 926556010244 ABC transporter signature motif; other site 926556010245 Walker B; other site 926556010246 D-loop; other site 926556010247 H-loop/switch region; other site 926556010248 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 926556010249 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 926556010250 active site 926556010251 dimer interface [polypeptide binding]; other site 926556010252 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 926556010253 dimer interface [polypeptide binding]; other site 926556010254 active site 926556010255 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 926556010256 Walker A/P-loop; other site 926556010257 ATP binding site [chemical binding]; other site 926556010258 Q-loop/lid; other site 926556010259 ABC transporter signature motif; other site 926556010260 Walker B; other site 926556010261 D-loop; other site 926556010262 H-loop/switch region; other site 926556010263 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 926556010264 PA14 domain; Region: PA14; cl08459 926556010265 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 926556010266 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 926556010267 putative active site [active] 926556010268 putative catalytic site [active] 926556010269 aconitate hydratase; Validated; Region: PRK09277 926556010270 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 926556010271 substrate binding site [chemical binding]; other site 926556010272 ligand binding site [chemical binding]; other site 926556010273 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 926556010274 substrate binding site [chemical binding]; other site 926556010275 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 926556010276 putative catalytic site [active] 926556010277 putative metal binding site [ion binding]; other site 926556010278 putative phosphate binding site [ion binding]; other site 926556010279 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 926556010280 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 926556010281 putative active site [active] 926556010282 putative NTP binding site [chemical binding]; other site 926556010283 putative nucleic acid binding site [nucleotide binding]; other site 926556010284 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 926556010285 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 926556010286 mce related protein; Region: MCE; pfam02470 926556010287 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 926556010288 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 926556010289 Walker A/P-loop; other site 926556010290 ATP binding site [chemical binding]; other site 926556010291 Q-loop/lid; other site 926556010292 ABC transporter signature motif; other site 926556010293 Walker B; other site 926556010294 D-loop; other site 926556010295 H-loop/switch region; other site 926556010296 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 926556010297 Permease; Region: Permease; pfam02405 926556010298 Response regulator receiver domain; Region: Response_reg; pfam00072 926556010299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556010300 active site 926556010301 phosphorylation site [posttranslational modification] 926556010302 intermolecular recognition site; other site 926556010303 dimerization interface [polypeptide binding]; other site 926556010304 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 926556010305 YCII-related domain; Region: YCII; cl00999 926556010306 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 926556010307 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 926556010308 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 926556010309 Uncharacterized conserved protein [Function unknown]; Region: COG1434 926556010310 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 926556010311 putative active site [active] 926556010312 FOG: CBS domain [General function prediction only]; Region: COG0517 926556010313 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 926556010314 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 926556010315 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 926556010316 active site 926556010317 dimer interface [polypeptide binding]; other site 926556010318 catalytic nucleophile [active] 926556010319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556010320 binding surface 926556010321 TPR motif; other site 926556010322 PspC domain; Region: PspC; cl00864 926556010323 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926556010324 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 926556010325 Probable Catalytic site; other site 926556010326 metal-binding site 926556010327 hypothetical protein; Validated; Region: PRK00153 926556010328 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 926556010329 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 926556010330 dimer interface [polypeptide binding]; other site 926556010331 motif 1; other site 926556010332 active site 926556010333 motif 2; other site 926556010334 motif 3; other site 926556010335 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 926556010336 anticodon binding site; other site 926556010337 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 926556010338 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 926556010339 G1 box; other site 926556010340 putative GEF interaction site [polypeptide binding]; other site 926556010341 GTP/Mg2+ binding site [chemical binding]; other site 926556010342 Switch I region; other site 926556010343 G2 box; other site 926556010344 G3 box; other site 926556010345 Switch II region; other site 926556010346 G4 box; other site 926556010347 G5 box; other site 926556010348 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 926556010349 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 926556010350 isocitrate dehydrogenase; Validated; Region: PRK09222 926556010351 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 926556010352 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 926556010353 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 926556010354 substrate binding site [chemical binding]; other site 926556010355 oxyanion hole (OAH) forming residues; other site 926556010356 trimer interface [polypeptide binding]; other site 926556010357 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 926556010358 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 926556010359 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 926556010360 trimer interface [polypeptide binding]; other site 926556010361 active site 926556010362 TPR repeat; Region: TPR_11; pfam13414 926556010363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556010364 binding surface 926556010365 TPR motif; other site 926556010366 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 926556010367 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556010368 binding surface 926556010369 TPR motif; other site 926556010370 Tetratricopeptide repeat; Region: TPR_16; pfam13432 926556010371 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 926556010372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556010373 binding surface 926556010374 TPR motif; other site 926556010375 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 926556010376 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 926556010377 Peptidase family M23; Region: Peptidase_M23; pfam01551 926556010378 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 926556010379 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 926556010380 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 926556010381 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 926556010382 N-acetyl-D-glucosamine binding site [chemical binding]; other site 926556010383 catalytic residue [active] 926556010384 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926556010385 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926556010386 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 926556010387 Malic enzyme, N-terminal domain; Region: malic; pfam00390 926556010388 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 926556010389 putative NAD(P) binding site [chemical binding]; other site 926556010390 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 926556010391 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 926556010392 RuvA N terminal domain; Region: RuvA_N; pfam01330 926556010393 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 926556010394 cell surface protein SprA; Region: surface_SprA; TIGR04189 926556010395 Motility related/secretion protein; Region: SprA_N; pfam14349 926556010396 Motility related/secretion protein; Region: SprA_N; pfam14349 926556010397 Motility related/secretion protein; Region: SprA_N; pfam14349 926556010398 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 926556010399 lipoyl attachment site [posttranslational modification]; other site 926556010400 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 926556010401 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 926556010402 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 926556010403 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 926556010404 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 926556010405 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 926556010406 catalytic residues [active] 926556010407 catalytic nucleophile [active] 926556010408 Recombinase; Region: Recombinase; pfam07508 926556010409 Domain of unknown function (DUF932); Region: DUF932; pfam06067 926556010410 Domain of unknown function (DUF4138); Region: DUF4138; pfam13595 926556010411 Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779 926556010412 Protein of unknown function (DUF3714); Region: DUF3714; pfam12508 926556010413 Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781 926556010414 Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782 926556010415 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 926556010416 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 926556010417 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 926556010418 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 926556010419 metal binding site 2 [ion binding]; metal-binding site 926556010420 putative DNA binding helix; other site 926556010421 metal binding site 1 [ion binding]; metal-binding site 926556010422 dimer interface [polypeptide binding]; other site 926556010423 structural Zn2+ binding site [ion binding]; other site 926556010424 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 926556010425 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926556010426 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 926556010427 Cation efflux family; Region: Cation_efflux; cl00316 926556010428 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 926556010429 metal binding site 2 [ion binding]; metal-binding site 926556010430 putative DNA binding helix; other site 926556010431 metal binding site 1 [ion binding]; metal-binding site 926556010432 dimer interface [polypeptide binding]; other site 926556010433 structural Zn2+ binding site [ion binding]; other site 926556010434 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 926556010435 Nitrogen regulatory protein P-II; Region: P-II; smart00938 926556010436 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926556010437 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556010438 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 926556010439 Colicin V production protein; Region: Colicin_V; pfam02674 926556010440 Outer membrane efflux protein; Region: OEP; pfam02321 926556010441 Outer membrane efflux protein; Region: OEP; pfam02321 926556010442 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 926556010443 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 926556010444 iron-sulfur cluster [ion binding]; other site 926556010445 [2Fe-2S] cluster binding site [ion binding]; other site 926556010446 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 926556010447 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 926556010448 metal-binding site [ion binding] 926556010449 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 926556010450 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926556010451 metal-binding site [ion binding] 926556010452 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926556010453 Soluble P-type ATPase [General function prediction only]; Region: COG4087 926556010454 Helix-turn-helix domain; Region: HTH_18; pfam12833 926556010455 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556010456 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 926556010457 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926556010458 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926556010459 motif II; other site 926556010460 Predicted permease; Region: DUF318; cl17795 926556010461 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 926556010462 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 926556010463 Multicopper oxidase; Region: Cu-oxidase; pfam00394 926556010464 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 926556010465 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 926556010466 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 926556010467 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926556010468 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556010469 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 926556010470 Outer membrane efflux protein; Region: OEP; pfam02321 926556010471 Outer membrane efflux protein; Region: OEP; pfam02321 926556010472 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 926556010473 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 926556010474 Protein export membrane protein; Region: SecD_SecF; cl14618 926556010475 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926556010476 metal-binding site [ion binding] 926556010477 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926556010478 metal-binding site [ion binding] 926556010479 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 926556010480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556010481 putative substrate translocation pore; other site 926556010482 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 926556010483 dimerization interface [polypeptide binding]; other site 926556010484 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 926556010485 Metal-sensitive transcriptional repressor; Region: Trns_repr_metal; pfam02583 926556010486 putative homotetramer interface [polypeptide binding]; other site 926556010487 putative homodimer interface [polypeptide binding]; other site 926556010488 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 926556010489 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 926556010490 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926556010491 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 926556010492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556010493 S-adenosylmethionine binding site [chemical binding]; other site 926556010494 MerT mercuric transport protein; Region: MerT; cl03578 926556010495 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926556010496 metal-binding site [ion binding] 926556010497 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926556010498 metal-binding site [ion binding] 926556010499 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926556010500 dimerization interface [polypeptide binding]; other site 926556010501 putative DNA binding site [nucleotide binding]; other site 926556010502 putative Zn2+ binding site [ion binding]; other site 926556010503 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 926556010504 DEAD-like helicases superfamily; Region: DEXDc; smart00487 926556010505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926556010506 ATP binding site [chemical binding]; other site 926556010507 putative Mg++ binding site [ion binding]; other site 926556010508 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 926556010509 nucleotide binding region [chemical binding]; other site 926556010510 ATP-binding site [chemical binding]; other site 926556010511 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 926556010512 Divergent AAA domain; Region: AAA_4; pfam04326 926556010513 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 926556010514 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 926556010515 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 926556010516 catalytic residues [active] 926556010517 catalytic nucleophile [active] 926556010518 Recombinase; Region: Recombinase; pfam07508 926556010519 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 926556010520 Ligand binding site; other site 926556010521 metal-binding site 926556010522 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 926556010523 MoaE homodimer interface [polypeptide binding]; other site 926556010524 MoaD interaction [polypeptide binding]; other site 926556010525 active site residues [active] 926556010526 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 926556010527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556010528 active site 926556010529 phosphorylation site [posttranslational modification] 926556010530 intermolecular recognition site; other site 926556010531 dimerization interface [polypeptide binding]; other site 926556010532 LytTr DNA-binding domain; Region: LytTR; smart00850 926556010533 Histidine kinase; Region: His_kinase; pfam06580 926556010534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556010535 ATP binding site [chemical binding]; other site 926556010536 Mg2+ binding site [ion binding]; other site 926556010537 G-X-G motif; other site 926556010538 SnoaL-like domain; Region: SnoaL_3; pfam13474 926556010539 SnoaL-like domain; Region: SnoaL_3; pfam13474 926556010540 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 926556010541 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 926556010542 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 926556010543 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 926556010544 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 926556010545 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 926556010546 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 926556010547 catalytic loop [active] 926556010548 iron binding site [ion binding]; other site 926556010549 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 926556010550 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 926556010551 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 926556010552 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 926556010553 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 926556010554 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 926556010555 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 926556010556 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926556010557 catalytic residue [active] 926556010558 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 926556010559 XdhC Rossmann domain; Region: XdhC_C; pfam13478 926556010560 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 926556010561 MoaE interaction surface [polypeptide binding]; other site 926556010562 MoeB interaction surface [polypeptide binding]; other site 926556010563 thiocarboxylated glycine; other site 926556010564 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 926556010565 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926556010566 FeS/SAM binding site; other site 926556010567 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 926556010568 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 926556010569 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 926556010570 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 926556010571 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 926556010572 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926556010573 catalytic site [active] 926556010574 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 926556010575 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 926556010576 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926556010577 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926556010578 active site 926556010579 catalytic tetrad [active] 926556010580 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926556010581 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926556010582 active site 926556010583 catalytic tetrad [active] 926556010584 Protein of unknown function (DUF418); Region: DUF418; pfam04235 926556010585 Helix-turn-helix domain; Region: HTH_18; pfam12833 926556010586 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556010587 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 926556010588 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 926556010589 catalytic residues [active] 926556010590 catalytic nucleophile [active] 926556010591 Recombinase; Region: Recombinase; pfam07508 926556010592 Domain of unknown function (DUF932); Region: DUF932; pfam06067 926556010593 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 926556010594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556010595 non-specific DNA binding site [nucleotide binding]; other site 926556010596 salt bridge; other site 926556010597 sequence-specific DNA binding site [nucleotide binding]; other site 926556010598 HipA N-terminal domain; Region: Couple_hipA; cl11853 926556010599 HipA-like N-terminal domain; Region: HipA_N; pfam07805 926556010600 HipA-like C-terminal domain; Region: HipA_C; pfam07804 926556010601 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 926556010602 conserved cys residue [active] 926556010603 Integrase core domain; Region: rve; pfam00665 926556010604 DDE domain; Region: DDE_Tnp_IS240; pfam13610 926556010605 Integrase core domain; Region: rve_3; pfam13683 926556010606 Transposase; Region: HTH_Tnp_1; pfam01527 926556010607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 926556010608 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 926556010609 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 926556010610 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 926556010611 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 926556010612 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926556010613 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 926556010614 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926556010615 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 926556010616 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 926556010617 transmembrane helices; other site 926556010618 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 926556010619 active site 926556010620 catalytic triad [active] 926556010621 oxyanion hole [active] 926556010622 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 926556010623 Domain of unknown function (DUF303); Region: DUF303; pfam03629 926556010624 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926556010625 Domain of unknown function (DUF303); Region: DUF303; pfam03629 926556010626 Right handed beta helix region; Region: Beta_helix; pfam13229 926556010627 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556010628 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556010629 SusD family; Region: SusD; pfam07980 926556010630 Secretin and TonB N terminus short domain; Region: STN; pfam07660 926556010631 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556010632 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556010633 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556010634 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556010635 FecR protein; Region: FecR; pfam04773 926556010636 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556010637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556010638 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556010639 DNA binding residues [nucleotide binding] 926556010640 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 926556010641 DEAD-like helicases superfamily; Region: DEXDc; smart00487 926556010642 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926556010643 ATP binding site [chemical binding]; other site 926556010644 putative Mg++ binding site [ion binding]; other site 926556010645 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 926556010646 nucleotide binding region [chemical binding]; other site 926556010647 ATP-binding site [chemical binding]; other site 926556010648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556010649 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926556010650 dimerization interface [polypeptide binding]; other site 926556010651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556010652 dimer interface [polypeptide binding]; other site 926556010653 phosphorylation site [posttranslational modification] 926556010654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556010655 ATP binding site [chemical binding]; other site 926556010656 Mg2+ binding site [ion binding]; other site 926556010657 G-X-G motif; other site 926556010658 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926556010659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556010660 active site 926556010661 phosphorylation site [posttranslational modification] 926556010662 intermolecular recognition site; other site 926556010663 dimerization interface [polypeptide binding]; other site 926556010664 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926556010665 DNA binding site [nucleotide binding] 926556010666 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 926556010667 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926556010668 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556010669 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 926556010670 Outer membrane efflux protein; Region: OEP; pfam02321 926556010671 Outer membrane efflux protein; Region: OEP; pfam02321 926556010672 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 926556010673 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 926556010674 nucleotide binding site [chemical binding]; other site 926556010675 homotetrameric interface [polypeptide binding]; other site 926556010676 putative phosphate binding site [ion binding]; other site 926556010677 putative allosteric binding site; other site 926556010678 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556010679 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926556010680 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 926556010681 N-terminal plug; other site 926556010682 ligand-binding site [chemical binding]; other site 926556010683 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 926556010684 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 926556010685 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 926556010686 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 926556010687 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926556010688 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926556010689 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556010690 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 926556010691 Surface antigen; Region: Bac_surface_Ag; pfam01103 926556010692 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 926556010693 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 926556010694 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 926556010695 Outer membrane efflux protein; Region: OEP; pfam02321 926556010696 Outer membrane efflux protein; Region: OEP; pfam02321 926556010697 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 926556010698 HlyD family secretion protein; Region: HlyD; pfam00529 926556010699 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 926556010700 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556010701 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926556010702 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926556010703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556010704 Walker A/P-loop; other site 926556010705 ATP binding site [chemical binding]; other site 926556010706 Q-loop/lid; other site 926556010707 ABC transporter signature motif; other site 926556010708 Walker B; other site 926556010709 D-loop; other site 926556010710 H-loop/switch region; other site 926556010711 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556010712 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556010713 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556010714 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556010715 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556010716 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556010717 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 926556010718 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 926556010719 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 926556010720 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 926556010721 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 926556010722 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 926556010723 active site 926556010724 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556010725 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926556010726 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556010727 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 926556010728 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 926556010729 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 926556010730 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556010731 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 926556010732 N terminal extension of bacteriophage endosialidase; Region: End_N_terminal; pfam12218 926556010733 Right handed beta helix region; Region: Beta_helix; pfam13229 926556010734 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 926556010735 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926556010736 active site 926556010737 Bacterial sugar transferase; Region: Bac_transf; pfam02397 926556010738 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 926556010739 active site 926556010740 NTP binding site [chemical binding]; other site 926556010741 metal binding triad [ion binding]; metal-binding site 926556010742 antibiotic binding site [chemical binding]; other site 926556010743 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 926556010744 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 926556010745 putative substrate binding site [chemical binding]; other site 926556010746 active site 926556010747 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 926556010748 MPN+ (JAMM) motif; other site 926556010749 Zinc-binding site [ion binding]; other site 926556010750 PAS domain S-box; Region: sensory_box; TIGR00229 926556010751 PAS domain; Region: PAS; smart00091 926556010752 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556010753 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 926556010754 putative active site [active] 926556010755 heme pocket [chemical binding]; other site 926556010756 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556010757 heme pocket [chemical binding]; other site 926556010758 putative active site [active] 926556010759 GAF domain; Region: GAF; pfam01590 926556010760 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926556010761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556010762 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 926556010763 putative active site [active] 926556010764 heme pocket [chemical binding]; other site 926556010765 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 926556010766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556010767 putative active site [active] 926556010768 heme pocket [chemical binding]; other site 926556010769 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 926556010770 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926556010771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556010772 active site 926556010773 phosphorylation site [posttranslational modification] 926556010774 intermolecular recognition site; other site 926556010775 dimerization interface [polypeptide binding]; other site 926556010776 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 926556010777 active site 926556010778 catalytic residues [active] 926556010779 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 926556010780 active site 926556010781 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556010782 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556010783 SusD family; Region: SusD; pfam07980 926556010784 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556010785 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556010786 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556010787 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556010788 SusD family; Region: SusD; pfam07980 926556010789 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556010790 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556010791 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556010792 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556010793 Two component regulator propeller; Region: Reg_prop; pfam07494 926556010794 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 926556010795 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 926556010796 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556010797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556010798 dimer interface [polypeptide binding]; other site 926556010799 phosphorylation site [posttranslational modification] 926556010800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556010801 ATP binding site [chemical binding]; other site 926556010802 Mg2+ binding site [ion binding]; other site 926556010803 G-X-G motif; other site 926556010804 Response regulator receiver domain; Region: Response_reg; pfam00072 926556010805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556010806 active site 926556010807 phosphorylation site [posttranslational modification] 926556010808 intermolecular recognition site; other site 926556010809 dimerization interface [polypeptide binding]; other site 926556010810 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 926556010811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556010812 Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782 926556010813 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 926556010814 Plant protein of unknown function (DUF639); Region: DUF639; pfam04842 926556010815 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 926556010816 putative hydrophobic ligand binding site [chemical binding]; other site 926556010817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926556010818 dimerization interface [polypeptide binding]; other site 926556010819 putative DNA binding site [nucleotide binding]; other site 926556010820 putative Zn2+ binding site [ion binding]; other site 926556010821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 926556010822 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 926556010823 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 926556010824 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 926556010825 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 926556010826 DoxX-like family; Region: DoxX_2; pfam13564 926556010827 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 926556010828 hydrophobic ligand binding site; other site 926556010829 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926556010830 dimerization interface [polypeptide binding]; other site 926556010831 putative DNA binding site [nucleotide binding]; other site 926556010832 putative Zn2+ binding site [ion binding]; other site 926556010833 Cupin domain; Region: Cupin_2; pfam07883 926556010834 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 926556010835 DoxX-like family; Region: DoxX_2; pfam13564 926556010836 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 926556010837 putative hydrophobic ligand binding site [chemical binding]; other site 926556010838 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 926556010839 dimer interface [polypeptide binding]; other site 926556010840 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926556010841 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926556010842 dimerization interface [polypeptide binding]; other site 926556010843 putative DNA binding site [nucleotide binding]; other site 926556010844 putative Zn2+ binding site [ion binding]; other site 926556010845 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 926556010846 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 926556010847 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 926556010848 Active site serine [active] 926556010849 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 926556010850 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 926556010851 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 926556010852 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 926556010853 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 926556010854 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926556010855 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 926556010856 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926556010857 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926556010858 ligand binding site [chemical binding]; other site 926556010859 flexible hinge region; other site 926556010860 RibD C-terminal domain; Region: RibD_C; cl17279 926556010861 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 926556010862 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 926556010863 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556010864 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556010865 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 926556010866 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556010867 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 926556010868 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556010869 YCII-related domain; Region: YCII; cl00999 926556010870 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 926556010871 TAP-like protein; Region: Abhydrolase_4; pfam08386 926556010872 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 926556010873 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926556010874 active site 926556010875 metal binding site [ion binding]; metal-binding site 926556010876 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 926556010877 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556010878 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556010879 DNA binding residues [nucleotide binding] 926556010880 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926556010881 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926556010882 active site 926556010883 catalytic tetrad [active] 926556010884 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 926556010885 RibD C-terminal domain; Region: RibD_C; cl17279 926556010886 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 926556010887 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 926556010888 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 926556010889 active site 926556010890 Amidohydrolase; Region: Amidohydro_4; pfam13147 926556010891 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926556010892 active site 926556010893 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 926556010894 Na binding site [ion binding]; other site 926556010895 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 926556010896 putative active site [active] 926556010897 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 926556010898 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 926556010899 active site 926556010900 trimer interface [polypeptide binding]; other site 926556010901 allosteric site; other site 926556010902 active site lid [active] 926556010903 hexamer (dimer of trimers) interface [polypeptide binding]; other site 926556010904 Fasciclin domain; Region: Fasciclin; cl02663 926556010905 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556010906 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556010907 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556010908 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556010909 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556010910 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926556010911 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 926556010912 DNA binding site [nucleotide binding] 926556010913 domain linker motif; other site 926556010914 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 926556010915 dimerization interface [polypeptide binding]; other site 926556010916 ligand binding site [chemical binding]; other site 926556010917 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556010918 SusD family; Region: SusD; pfam07980 926556010919 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556010920 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556010921 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556010922 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556010923 FecR protein; Region: FecR; pfam04773 926556010924 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556010925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556010926 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 926556010927 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556010928 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 926556010929 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 926556010930 N-terminal plug; other site 926556010931 ligand-binding site [chemical binding]; other site 926556010932 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556010933 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556010934 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 926556010935 DNA binding residues [nucleotide binding] 926556010936 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556010937 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926556010938 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 926556010939 N-terminal plug; other site 926556010940 ligand-binding site [chemical binding]; other site 926556010941 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 926556010942 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 926556010943 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 926556010944 Predicted ATPase [General function prediction only]; Region: COG3911 926556010945 AAA domain; Region: AAA_28; pfam13521 926556010946 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 926556010947 active site 926556010948 catalytic triad [active] 926556010949 oxyanion hole [active] 926556010950 Domain of unknown function (DUF303); Region: DUF303; pfam03629 926556010951 Creatinine amidohydrolase; Region: Creatininase; pfam02633 926556010952 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 926556010953 dimerization interface [polypeptide binding]; other site 926556010954 putative active cleft [active] 926556010955 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556010956 Sulfatase; Region: Sulfatase; pfam00884 926556010957 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 926556010958 catalytic site [active] 926556010959 BNR repeat-like domain; Region: BNR_2; pfam13088 926556010960 Asp-box motif; other site 926556010961 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 926556010962 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 926556010963 Na binding site [ion binding]; other site 926556010964 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 926556010965 Class I aldolases; Region: Aldolase_Class_I; cl17187 926556010966 catalytic residue [active] 926556010967 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556010968 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556010969 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556010970 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556010971 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 926556010972 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556010973 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 926556010974 Two component regulator propeller; Region: Reg_prop; pfam07494 926556010975 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 926556010976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556010977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556010978 dimer interface [polypeptide binding]; other site 926556010979 phosphorylation site [posttranslational modification] 926556010980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556010981 ATP binding site [chemical binding]; other site 926556010982 Mg2+ binding site [ion binding]; other site 926556010983 G-X-G motif; other site 926556010984 Response regulator receiver domain; Region: Response_reg; pfam00072 926556010985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556010986 active site 926556010987 phosphorylation site [posttranslational modification] 926556010988 intermolecular recognition site; other site 926556010989 dimerization interface [polypeptide binding]; other site 926556010990 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 926556010991 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556010992 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 926556010993 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926556010994 active site 926556010995 DNA binding site [nucleotide binding] 926556010996 Int/Topo IB signature motif; other site 926556010997 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926556010998 active site 926556010999 DNA binding site [nucleotide binding] 926556011000 Int/Topo IB signature motif; other site 926556011001 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 926556011002 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 926556011003 Int/Topo IB signature motif; other site 926556011004 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 926556011005 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556011006 Sulfatase; Region: Sulfatase; pfam00884 926556011007 Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780 926556011008 Domain of unknown function (DUF4138); Region: DUF4138; pfam13595 926556011009 Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779 926556011010 Protein of unknown function (DUF3714); Region: DUF3714; pfam12508 926556011011 Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781 926556011012 Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782 926556011013 Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991 926556011014 Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783 926556011015 Domain of unknown function DUF87; Region: DUF87; pfam01935 926556011016 Domain of unknown function (DUF4133); Region: DUF4133; pfam13571 926556011017 Domain of unknown function (DUF4134); Region: DUF4134; pfam13572 926556011018 RteC protein; Region: RteC; pfam09357 926556011019 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 926556011020 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556011021 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556011022 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556011023 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556011024 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556011025 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556011026 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926556011027 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556011028 catalytic residues [active] 926556011029 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 926556011030 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926556011031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556011032 active site 926556011033 phosphorylation site [posttranslational modification] 926556011034 intermolecular recognition site; other site 926556011035 dimerization interface [polypeptide binding]; other site 926556011036 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926556011037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556011038 binding surface 926556011039 TPR motif; other site 926556011040 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926556011041 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926556011042 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926556011043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 926556011044 binding surface 926556011045 TPR motif; other site 926556011046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556011047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556011048 dimer interface [polypeptide binding]; other site 926556011049 phosphorylation site [posttranslational modification] 926556011050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556011051 ATP binding site [chemical binding]; other site 926556011052 Mg2+ binding site [ion binding]; other site 926556011053 G-X-G motif; other site 926556011054 YWFCY protein; Region: YWFCY; pfam14293 926556011055 Domain of unknown function DUF87; Region: DUF87; pfam01935 926556011056 AAA-like domain; Region: AAA_10; pfam12846 926556011057 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 926556011058 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 926556011059 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 926556011060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 926556011061 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 926556011062 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926556011063 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 926556011064 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 926556011065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 926556011066 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926556011067 active site 926556011068 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 926556011069 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 926556011070 Mg++ binding site [ion binding]; other site 926556011071 putative catalytic motif [active] 926556011072 substrate binding site [chemical binding]; other site 926556011073 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 926556011074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926556011075 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926556011076 NAD(P) binding site [chemical binding]; other site 926556011077 active site 926556011078 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 926556011079 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926556011080 active site 926556011081 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926556011082 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556011083 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926556011084 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926556011085 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 926556011086 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 926556011087 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 926556011088 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 926556011089 inhibitor-cofactor binding pocket; inhibition site 926556011090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556011091 catalytic residue [active] 926556011092 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 926556011093 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 926556011094 NADP binding site [chemical binding]; other site 926556011095 active site 926556011096 putative substrate binding site [chemical binding]; other site 926556011097 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 926556011098 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 926556011099 NADP-binding site; other site 926556011100 homotetramer interface [polypeptide binding]; other site 926556011101 substrate binding site [chemical binding]; other site 926556011102 homodimer interface [polypeptide binding]; other site 926556011103 active site 926556011104 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 926556011105 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 926556011106 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 926556011107 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 926556011108 Chain length determinant protein; Region: Wzz; cl15801 926556011109 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 926556011110 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 926556011111 SLBB domain; Region: SLBB; pfam10531 926556011112 SLBB domain; Region: SLBB; pfam10531 926556011113 SLBB domain; Region: SLBB; pfam10531 926556011114 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 926556011115 SLBB domain; Region: SLBB; pfam10531 926556011116 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 926556011117 GIY-YIG motif/motif A; other site 926556011118 putative active site [active] 926556011119 putative metal binding site [ion binding]; other site 926556011120 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 926556011121 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 926556011122 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 926556011123 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 926556011124 putative DNA binding site [nucleotide binding]; other site 926556011125 dimerization interface [polypeptide binding]; other site 926556011126 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 926556011127 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 926556011128 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 926556011129 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 926556011130 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 926556011131 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 926556011132 active site 926556011133 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 926556011134 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 926556011135 Substrate binding site; other site 926556011136 Cupin domain; Region: Cupin_2; cl17218 926556011137 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 926556011138 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 926556011139 NAD binding site [chemical binding]; other site 926556011140 substrate binding site [chemical binding]; other site 926556011141 homodimer interface [polypeptide binding]; other site 926556011142 active site 926556011143 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 926556011144 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 926556011145 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 926556011146 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 926556011147 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 926556011148 classical (c) SDRs; Region: SDR_c; cd05233 926556011149 NAD(P) binding site [chemical binding]; other site 926556011150 active site 926556011151 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 926556011152 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 926556011153 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 926556011154 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 926556011155 dimer interface [polypeptide binding]; other site 926556011156 tetramer interface [polypeptide binding]; other site 926556011157 PYR/PP interface [polypeptide binding]; other site 926556011158 TPP binding site [chemical binding]; other site 926556011159 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 926556011160 TPP-binding site; other site 926556011161 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 926556011162 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 926556011163 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 926556011164 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 926556011165 active site 926556011166 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 926556011167 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 926556011168 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 926556011169 putative catalytic site [active] 926556011170 putative metal binding site [ion binding]; other site 926556011171 putative phosphate binding site [ion binding]; other site 926556011172 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 926556011173 Zn binding site [ion binding]; other site 926556011174 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 926556011175 Protein export membrane protein; Region: SecD_SecF; cl14618 926556011176 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926556011177 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926556011178 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556011179 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 926556011180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926556011181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926556011182 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 926556011183 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 926556011184 dimerization interface [polypeptide binding]; other site 926556011185 ATP binding site [chemical binding]; other site 926556011186 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 926556011187 dimerization interface [polypeptide binding]; other site 926556011188 ATP binding site [chemical binding]; other site 926556011189 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 926556011190 putative active site [active] 926556011191 catalytic triad [active] 926556011192 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 926556011193 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 926556011194 catalytic residues [active] 926556011195 catalytic nucleophile [active] 926556011196 Recombinase; Region: Recombinase; pfam07508 926556011197 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 926556011198 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 926556011199 MPN+ (JAMM) motif; other site 926556011200 Zinc-binding site [ion binding]; other site 926556011201 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 926556011202 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 926556011203 DinB family; Region: DinB; cl17821 926556011204 DinB superfamily; Region: DinB_2; pfam12867 926556011205 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 926556011206 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 926556011207 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926556011208 ATP binding site [chemical binding]; other site 926556011209 putative Mg++ binding site [ion binding]; other site 926556011210 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 926556011211 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 926556011212 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 926556011213 Abi-like protein; Region: Abi_2; cl01988 926556011214 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 926556011215 Int/Topo IB signature motif; other site 926556011216 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 926556011217 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 926556011218 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 926556011219 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 926556011220 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 926556011221 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 926556011222 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 926556011223 HsdM N-terminal domain; Region: HsdM_N; pfam12161 926556011224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556011225 S-adenosylmethionine binding site [chemical binding]; other site 926556011226 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 926556011227 Part of AAA domain; Region: AAA_19; pfam13245 926556011228 Enterobacteria AfaD invasin protein; Region: AfaD; cl05376 926556011229 AAA ATPase domain; Region: AAA_15; pfam13175 926556011230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926556011231 Walker A/P-loop; other site 926556011232 ATP binding site [chemical binding]; other site 926556011233 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 926556011234 putative active site [active] 926556011235 putative metal-binding site [ion binding]; other site 926556011236 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 926556011237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556011238 non-specific DNA binding site [nucleotide binding]; other site 926556011239 salt bridge; other site 926556011240 sequence-specific DNA binding site [nucleotide binding]; other site 926556011241 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926556011242 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556011243 catalytic residues [active] 926556011244 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 926556011245 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556011246 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556011247 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556011248 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556011249 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556011250 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926556011251 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926556011252 ligand binding site [chemical binding]; other site 926556011253 flexible hinge region; other site 926556011254 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 926556011255 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 926556011256 Phospholipid methyltransferase; Region: PEMT; cl17370 926556011257 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 926556011258 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 926556011259 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 926556011260 Cation efflux family; Region: Cation_efflux; pfam01545 926556011261 Heavy-metal-associated domain; Region: HMA; pfam00403 926556011262 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 926556011263 Domain of unknown function DUF302; Region: DUF302; cl01364 926556011264 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 926556011265 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926556011266 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 926556011267 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 926556011268 MgtC family; Region: MgtC; pfam02308 926556011269 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 926556011270 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 926556011271 Iron permease FTR1 family; Region: FTR1; cl00475 926556011272 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 926556011273 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926556011274 Soluble P-type ATPase [General function prediction only]; Region: COG4087 926556011275 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 926556011276 metal binding site 2 [ion binding]; metal-binding site 926556011277 putative DNA binding helix; other site 926556011278 metal binding site 1 [ion binding]; metal-binding site 926556011279 dimer interface [polypeptide binding]; other site 926556011280 structural Zn2+ binding site [ion binding]; other site 926556011281 Divergent AAA domain; Region: AAA_4; pfam04326 926556011282 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926556011283 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556011284 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 926556011285 Outer membrane efflux protein; Region: OEP; pfam02321 926556011286 Outer membrane efflux protein; Region: OEP; pfam02321 926556011287 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926556011288 metal-binding site [ion binding] 926556011289 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926556011290 metal-binding site [ion binding] 926556011291 mercuric reductase; Region: MerA; TIGR02053 926556011292 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926556011293 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926556011294 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 926556011295 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926556011296 metal-binding site [ion binding] 926556011297 MerT mercuric transport protein; Region: MerT; cl03578 926556011298 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926556011299 metal-binding site [ion binding] 926556011300 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926556011301 dimerization interface [polypeptide binding]; other site 926556011302 putative DNA binding site [nucleotide binding]; other site 926556011303 putative Zn2+ binding site [ion binding]; other site 926556011304 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 926556011305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 926556011306 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 926556011307 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 926556011308 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 926556011309 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 926556011310 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 926556011311 putative DNA binding site [nucleotide binding]; other site 926556011312 putative Zn2+ binding site [ion binding]; other site 926556011313 Fic family protein [Function unknown]; Region: COG3177 926556011314 Fic/DOC family; Region: Fic; pfam02661 926556011315 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 926556011316 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 926556011317 heme-binding site [chemical binding]; other site 926556011318 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 926556011319 FAD binding pocket [chemical binding]; other site 926556011320 FAD binding motif [chemical binding]; other site 926556011321 phosphate binding motif [ion binding]; other site 926556011322 beta-alpha-beta structure motif; other site 926556011323 NAD binding pocket [chemical binding]; other site 926556011324 Heme binding pocket [chemical binding]; other site 926556011325 Rrf2 family protein; Region: rrf2_super; TIGR00738 926556011326 Transcriptional regulator; Region: Rrf2; pfam02082 926556011327 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 926556011328 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 926556011329 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 926556011330 Helix-turn-helix domain; Region: HTH_18; pfam12833 926556011331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556011332 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 926556011333 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 926556011334 DNA interaction; other site 926556011335 Metal-binding active site; metal-binding site 926556011336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556011337 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926556011338 putative substrate translocation pore; other site 926556011339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926556011340 putative oxidoreductase; Provisional; Region: PRK11579 926556011341 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926556011342 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 926556011343 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 926556011344 Major royal jelly protein; Region: MRJP; pfam03022 926556011345 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 926556011346 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926556011347 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 926556011348 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 926556011349 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 926556011350 homodimer interface [polypeptide binding]; other site 926556011351 substrate-cofactor binding pocket; other site 926556011352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556011353 catalytic residue [active] 926556011354 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926556011355 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926556011356 active site 926556011357 catalytic tetrad [active] 926556011358 Domain of unknown function (DUF303); Region: DUF303; pfam03629 926556011359 ribulokinase; Provisional; Region: PRK04123 926556011360 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 926556011361 N- and C-terminal domain interface [polypeptide binding]; other site 926556011362 active site 926556011363 MgATP binding site [chemical binding]; other site 926556011364 catalytic site [active] 926556011365 metal binding site [ion binding]; metal-binding site 926556011366 carbohydrate binding site [chemical binding]; other site 926556011367 homodimer interface [polypeptide binding]; other site 926556011368 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 926556011369 Na binding site [ion binding]; other site 926556011370 dihydrodipicolinate synthase; Region: dapA; TIGR00674 926556011371 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 926556011372 inhibitor site; inhibition site 926556011373 active site 926556011374 dimer interface [polypeptide binding]; other site 926556011375 catalytic residue [active] 926556011376 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 926556011377 Family description; Region: VCBS; pfam13517 926556011378 Family description; Region: VCBS; pfam13517 926556011379 Family description; Region: VCBS; pfam13517 926556011380 Family description; Region: VCBS; pfam13517 926556011381 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556011382 Sulfatase; Region: Sulfatase; pfam00884 926556011383 BNR repeat-like domain; Region: BNR_2; pfam13088 926556011384 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556011385 Sulfatase; Region: Sulfatase; pfam00884 926556011386 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556011387 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556011388 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556011389 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556011390 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556011391 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 926556011392 hexamer (dimer of trimers) interface [polypeptide binding]; other site 926556011393 substrate binding site [chemical binding]; other site 926556011394 trimer interface [polypeptide binding]; other site 926556011395 Mn binding site [ion binding]; other site 926556011396 Cupin domain; Region: Cupin_2; pfam07883 926556011397 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 926556011398 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926556011399 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 926556011400 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 926556011401 active site 926556011402 catalytic residues [active] 926556011403 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 926556011404 putative catalytic site [active] 926556011405 putative metal binding site [ion binding]; other site 926556011406 putative phosphate binding site [ion binding]; other site 926556011407 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 926556011408 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556011409 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556011410 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556011411 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556011412 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556011413 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 926556011414 FecR protein; Region: FecR; pfam04773 926556011415 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556011416 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556011417 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556011418 DNA binding residues [nucleotide binding] 926556011419 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926556011420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556011421 TPR motif; other site 926556011422 binding surface 926556011423 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926556011424 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926556011425 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 926556011426 DNA binding residues [nucleotide binding] 926556011427 Phytase; Region: Phytase; cl17685 926556011428 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926556011429 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 926556011430 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556011431 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 926556011432 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 926556011433 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 926556011434 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 926556011435 Walker A/P-loop; other site 926556011436 ATP binding site [chemical binding]; other site 926556011437 Q-loop/lid; other site 926556011438 ABC transporter signature motif; other site 926556011439 Walker B; other site 926556011440 D-loop; other site 926556011441 H-loop/switch region; other site 926556011442 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 926556011443 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 926556011444 Calx-beta domain; Region: Calx-beta; cl02522 926556011445 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926556011446 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 926556011447 Phage Tail Collar Domain; Region: Collar; pfam07484 926556011448 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 926556011449 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 926556011450 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926556011451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556011452 active site 926556011453 phosphorylation site [posttranslational modification] 926556011454 intermolecular recognition site; other site 926556011455 dimerization interface [polypeptide binding]; other site 926556011456 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926556011457 DNA binding residues [nucleotide binding] 926556011458 dimerization interface [polypeptide binding]; other site 926556011459 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 926556011460 Histidine kinase; Region: HisKA_3; pfam07730 926556011461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556011462 ATP binding site [chemical binding]; other site 926556011463 Mg2+ binding site [ion binding]; other site 926556011464 G-X-G motif; other site 926556011465 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 926556011466 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926556011467 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 926556011468 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 926556011469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 926556011470 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926556011471 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556011472 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 926556011473 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926556011474 non-specific DNA binding site [nucleotide binding]; other site 926556011475 salt bridge; other site 926556011476 sequence-specific DNA binding site [nucleotide binding]; other site 926556011477 Cupin domain; Region: Cupin_2; pfam07883 926556011478 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 926556011479 catalytic Zn binding site [ion binding]; other site 926556011480 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 926556011481 structural Zn binding site [ion binding]; other site 926556011482 tetramer interface [polypeptide binding]; other site 926556011483 hydroxyglutarate oxidase; Provisional; Region: PRK11728 926556011484 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 926556011485 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 926556011486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926556011487 motif II; other site 926556011488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 926556011489 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556011490 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556011491 SusD family; Region: SusD; pfam07980 926556011492 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556011493 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556011494 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556011495 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556011496 FecR protein; Region: FecR; pfam04773 926556011497 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 926556011498 active site 926556011499 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 926556011500 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556011501 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926556011502 DNA binding residues [nucleotide binding] 926556011503 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556011504 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926556011505 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556011506 Domain of unknown function (DUF4374); Region: DUF4374; pfam14298 926556011507 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 926556011508 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 926556011509 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926556011510 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926556011511 catalytic residues [active] 926556011512 PAS domain S-box; Region: sensory_box; TIGR00229 926556011513 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556011514 putative active site [active] 926556011515 heme pocket [chemical binding]; other site 926556011516 PAS fold; Region: PAS_3; pfam08447 926556011517 PAS domain S-box; Region: sensory_box; TIGR00229 926556011518 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926556011519 putative active site [active] 926556011520 heme pocket [chemical binding]; other site 926556011521 PAS fold; Region: PAS_4; pfam08448 926556011522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556011523 dimer interface [polypeptide binding]; other site 926556011524 phosphorylation site [posttranslational modification] 926556011525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556011526 ATP binding site [chemical binding]; other site 926556011527 Mg2+ binding site [ion binding]; other site 926556011528 G-X-G motif; other site 926556011529 Response regulator receiver domain; Region: Response_reg; pfam00072 926556011530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556011531 active site 926556011532 phosphorylation site [posttranslational modification] 926556011533 intermolecular recognition site; other site 926556011534 dimerization interface [polypeptide binding]; other site 926556011535 Response regulator receiver domain; Region: Response_reg; pfam00072 926556011536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556011537 active site 926556011538 phosphorylation site [posttranslational modification] 926556011539 intermolecular recognition site; other site 926556011540 dimerization interface [polypeptide binding]; other site 926556011541 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926556011542 active site 926556011543 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 926556011544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556011545 active site 926556011546 phosphorylation site [posttranslational modification] 926556011547 intermolecular recognition site; other site 926556011548 dimerization interface [polypeptide binding]; other site 926556011549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556011550 Walker A motif; other site 926556011551 ATP binding site [chemical binding]; other site 926556011552 Walker B motif; other site 926556011553 arginine finger; other site 926556011554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926556011555 Response regulator receiver domain; Region: Response_reg; pfam00072 926556011556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556011557 active site 926556011558 phosphorylation site [posttranslational modification] 926556011559 intermolecular recognition site; other site 926556011560 dimerization interface [polypeptide binding]; other site 926556011561 Hpt domain; Region: Hpt; pfam01627 926556011562 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926556011563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556011564 active site 926556011565 phosphorylation site [posttranslational modification] 926556011566 intermolecular recognition site; other site 926556011567 dimerization interface [polypeptide binding]; other site 926556011568 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 926556011569 DNA binding residues [nucleotide binding] 926556011570 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926556011571 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556011572 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556011573 DNA binding residues [nucleotide binding] 926556011574 Conserved TM helix; Region: TM_helix; pfam05552 926556011575 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926556011576 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 926556011577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556011578 homodimer interface [polypeptide binding]; other site 926556011579 catalytic residue [active] 926556011580 Oxygen tolerance; Region: BatD; pfam13584 926556011581 von Willebrand factor type A domain; Region: VWA_2; pfam13519 926556011582 metal ion-dependent adhesion site (MIDAS); other site 926556011583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556011584 binding surface 926556011585 TPR motif; other site 926556011586 TPR repeat; Region: TPR_11; pfam13414 926556011587 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 926556011588 metal ion-dependent adhesion site (MIDAS); other site 926556011589 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 926556011590 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 926556011591 Protein of unknown function DUF58; Region: DUF58; pfam01882 926556011592 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 926556011593 MoxR-like ATPases [General function prediction only]; Region: COG0714 926556011594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556011595 Walker A motif; other site 926556011596 ATP binding site [chemical binding]; other site 926556011597 Walker B motif; other site 926556011598 arginine finger; other site 926556011599 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556011600 Sulfatase; Region: Sulfatase; pfam00884 926556011601 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926556011602 Sulfatase; Region: Sulfatase; pfam00884 926556011603 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 926556011604 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 926556011605 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 926556011606 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 926556011607 active site 926556011608 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 926556011609 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 926556011610 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 926556011611 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926556011612 active site 926556011613 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 926556011614 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 926556011615 5S rRNA interface [nucleotide binding]; other site 926556011616 CTC domain interface [polypeptide binding]; other site 926556011617 L16 interface [polypeptide binding]; other site 926556011618 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 926556011619 putative active site [active] 926556011620 catalytic residue [active] 926556011621 Domain of unknown function DUF77; Region: DUF77; pfam01910 926556011622 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926556011623 Sds3-like; Region: Sds3; pfam08598 926556011624 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926556011625 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926556011626 ligand binding site [chemical binding]; other site 926556011627 recombination factor protein RarA; Reviewed; Region: PRK13342 926556011628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556011629 Walker A motif; other site 926556011630 ATP binding site [chemical binding]; other site 926556011631 Walker B motif; other site 926556011632 arginine finger; other site 926556011633 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 926556011634 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 926556011635 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 926556011636 tetramer interface [polypeptide binding]; other site 926556011637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556011638 catalytic residue [active] 926556011639 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 926556011640 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 926556011641 putative active site [active] 926556011642 catalytic site [active] 926556011643 putative metal binding site [ion binding]; other site 926556011644 oligomer interface [polypeptide binding]; other site 926556011645 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 926556011646 Anti-sigma-K factor rskA; Region: RskA; pfam10099 926556011647 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926556011648 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926556011649 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926556011650 DNA binding residues [nucleotide binding] 926556011651 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 926556011652 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926556011653 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926556011654 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 926556011655 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 926556011656 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 926556011657 NAD(P) binding site [chemical binding]; other site 926556011658 homotetramer interface [polypeptide binding]; other site 926556011659 homodimer interface [polypeptide binding]; other site 926556011660 active site 926556011661 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 926556011662 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 926556011663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 926556011664 Outer membrane efflux protein; Region: OEP; pfam02321 926556011665 Outer membrane efflux protein; Region: OEP; pfam02321 926556011666 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926556011667 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 926556011668 FtsX-like permease family; Region: FtsX; pfam02687 926556011669 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926556011670 HlyD family secretion protein; Region: HlyD_3; pfam13437 926556011671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926556011672 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926556011673 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926556011674 active site 926556011675 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 926556011676 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 926556011677 Ligand binding site; other site 926556011678 Putative Catalytic site; other site 926556011679 DXD motif; other site 926556011680 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 926556011681 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 926556011682 dihydroorotase; Validated; Region: pyrC; PRK09357 926556011683 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 926556011684 active site 926556011685 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 926556011686 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 926556011687 GDP-binding site [chemical binding]; other site 926556011688 ACT binding site; other site 926556011689 IMP binding site; other site 926556011690 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 926556011691 anti sigma factor interaction site; other site 926556011692 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 926556011693 regulatory phosphorylation site [posttranslational modification]; other site 926556011694 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 926556011695 metal binding site 2 [ion binding]; metal-binding site 926556011696 putative DNA binding helix; other site 926556011697 metal binding site 1 [ion binding]; metal-binding site 926556011698 dimer interface [polypeptide binding]; other site 926556011699 structural Zn2+ binding site [ion binding]; other site 926556011700 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 926556011701 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926556011702 Zn2+ binding site [ion binding]; other site 926556011703 Mg2+ binding site [ion binding]; other site 926556011704 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 926556011705 synthetase active site [active] 926556011706 NTP binding site [chemical binding]; other site 926556011707 metal binding site [ion binding]; metal-binding site 926556011708 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 926556011709 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 926556011710 trigger factor; Region: tig; TIGR00115 926556011711 Clp protease; Region: CLP_protease; pfam00574 926556011712 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 926556011713 oligomer interface [polypeptide binding]; other site 926556011714 active site residues [active] 926556011715 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 926556011716 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 926556011717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556011718 Walker A motif; other site 926556011719 ATP binding site [chemical binding]; other site 926556011720 Walker B motif; other site 926556011721 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 926556011722 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 926556011723 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 926556011724 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 926556011725 active site 926556011726 starch binding outer membrane protein SusD; Region: SusD; cl17845 926556011727 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556011728 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556011729 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556011730 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926556011731 TPR repeat; Region: TPR_11; pfam13414 926556011732 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926556011733 binding surface 926556011734 TPR motif; other site 926556011735 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926556011736 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926556011737 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926556011738 ligand binding site [chemical binding]; other site 926556011739 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 926556011740 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926556011741 FeS/SAM binding site; other site 926556011742 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 926556011743 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 926556011744 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 926556011745 homodimer interface [polypeptide binding]; other site 926556011746 NADP binding site [chemical binding]; other site 926556011747 substrate binding site [chemical binding]; other site 926556011748 GTP-binding protein LepA; Provisional; Region: PRK05433 926556011749 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 926556011750 G1 box; other site 926556011751 putative GEF interaction site [polypeptide binding]; other site 926556011752 GTP/Mg2+ binding site [chemical binding]; other site 926556011753 Switch I region; other site 926556011754 G2 box; other site 926556011755 G3 box; other site 926556011756 Switch II region; other site 926556011757 G4 box; other site 926556011758 G5 box; other site 926556011759 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 926556011760 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 926556011761 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 926556011762 starch binding outer membrane protein SusD; Region: SusD; cd08977 926556011763 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926556011764 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926556011765 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926556011766 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926556011767 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926556011768 AAA domain; Region: AAA_11; pfam13086 926556011769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926556011770 ATP binding site [chemical binding]; other site 926556011771 AAA domain; Region: AAA_12; pfam13087 926556011772 Protein of unknown function, DUF479; Region: DUF479; cl01203 926556011773 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 926556011774 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 926556011775 oligomer interface [polypeptide binding]; other site 926556011776 active site 926556011777 metal binding site [ion binding]; metal-binding site 926556011778 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 926556011779 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 926556011780 active site 926556011781 glutamate racemase; Provisional; Region: PRK00865 926556011782 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 926556011783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556011784 active site 926556011785 phosphorylation site [posttranslational modification] 926556011786 intermolecular recognition site; other site 926556011787 dimerization interface [polypeptide binding]; other site 926556011788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556011789 Walker A motif; other site 926556011790 ATP binding site [chemical binding]; other site 926556011791 Walker B motif; other site 926556011792 arginine finger; other site 926556011793 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 926556011794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926556011795 dimer interface [polypeptide binding]; other site 926556011796 phosphorylation site [posttranslational modification] 926556011797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926556011798 ATP binding site [chemical binding]; other site 926556011799 Mg2+ binding site [ion binding]; other site 926556011800 G-X-G motif; other site 926556011801 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926556011802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926556011803 active site 926556011804 phosphorylation site [posttranslational modification] 926556011805 intermolecular recognition site; other site 926556011806 dimerization interface [polypeptide binding]; other site 926556011807 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 926556011808 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 926556011809 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 926556011810 dimer interface [polypeptide binding]; other site 926556011811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926556011812 catalytic residue [active] 926556011813 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 926556011814 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 926556011815 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 926556011816 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 926556011817 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 926556011818 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926556011819 active site 926556011820 DNA polymerase IV (family X) [DNA replication, recombination, and repair]; Region: POL4; COG1796 926556011821 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 926556011822 metal binding triad [ion binding]; metal-binding site 926556011823 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 926556011824 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 926556011825 active site 926556011826 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 926556011827 DNA-binding site [nucleotide binding]; DNA binding site 926556011828 RNA-binding motif; other site 926556011829 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 926556011830 catalytic core [active] 926556011831 short chain dehydrogenase; Provisional; Region: PRK06924 926556011832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926556011833 NAD(P) binding site [chemical binding]; other site 926556011834 active site 926556011835 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 926556011836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556011837 Walker A motif; other site 926556011838 ATP binding site [chemical binding]; other site 926556011839 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 926556011840 Walker B motif; other site 926556011841 arginine finger; other site 926556011842 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 926556011843 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 926556011844 Found in ATP-dependent protease La (LON); Region: LON; smart00464 926556011845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926556011846 Walker A motif; other site 926556011847 ATP binding site [chemical binding]; other site 926556011848 Walker B motif; other site 926556011849 arginine finger; other site 926556011850 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 926556011851 RIP metalloprotease RseP; Region: TIGR00054 926556011852 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 926556011853 active site 926556011854 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 926556011855 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 926556011856 putative substrate binding region [chemical binding]; other site 926556011857 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 926556011858 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 926556011859 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 926556011860 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 926556011861 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 926556011862 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 926556011863 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 926556011864 protein binding site [polypeptide binding]; other site 926556011865 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 926556011866 Uncharacterized conserved protein [Function unknown]; Region: COG5276 926556011867 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 926556011868 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 926556011869 putative ligand binding site [chemical binding]; other site 926556011870 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 926556011871 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 926556011872 ABC-ATPase subunit interface; other site 926556011873 dimer interface [polypeptide binding]; other site 926556011874 putative PBP binding regions; other site 926556011875 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 926556011876 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 926556011877 Walker A/P-loop; other site 926556011878 ATP binding site [chemical binding]; other site 926556011879 Q-loop/lid; other site 926556011880 ABC transporter signature motif; other site 926556011881 Walker B; other site 926556011882 D-loop; other site 926556011883 H-loop/switch region; other site 926556011884 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 926556011885 MarR family; Region: MarR; pfam01047 926556011886 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 926556011887 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926556011888 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926556011889 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 926556011890 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 926556011891 catalytic loop [active] 926556011892 iron binding site [ion binding]; other site 926556011893 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 926556011894 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 926556011895 active site 926556011896 substrate binding site [chemical binding]; other site 926556011897 coenzyme B12 binding site [chemical binding]; other site 926556011898 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 926556011899 B12 binding site [chemical binding]; other site 926556011900 cobalt ligand [ion binding]; other site 926556011901 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817