-- dump date 20140619_065917 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1260251000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1260251000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1260251000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251000004 Walker A motif; other site 1260251000005 ATP binding site [chemical binding]; other site 1260251000006 Walker B motif; other site 1260251000007 arginine finger; other site 1260251000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1260251000009 DnaA box-binding interface [nucleotide binding]; other site 1260251000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1260251000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1260251000012 putative DNA binding surface [nucleotide binding]; other site 1260251000013 dimer interface [polypeptide binding]; other site 1260251000014 beta-clamp/clamp loader binding surface; other site 1260251000015 beta-clamp/translesion DNA polymerase binding surface; other site 1260251000016 recombination protein F; Reviewed; Region: recF; PRK00064 1260251000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1260251000018 Walker A/P-loop; other site 1260251000019 ATP binding site [chemical binding]; other site 1260251000020 Q-loop/lid; other site 1260251000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1260251000022 ABC transporter signature motif; other site 1260251000023 Walker B; other site 1260251000024 D-loop; other site 1260251000025 H-loop/switch region; other site 1260251000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1260251000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1260251000028 Mg2+ binding site [ion binding]; other site 1260251000029 G-X-G motif; other site 1260251000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1260251000031 anchoring element; other site 1260251000032 dimer interface [polypeptide binding]; other site 1260251000033 ATP binding site [chemical binding]; other site 1260251000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1260251000035 active site 1260251000036 putative metal-binding site [ion binding]; other site 1260251000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1260251000038 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1260251000039 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1260251000040 putative acyl-acceptor binding pocket; other site 1260251000041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1260251000042 motif I; other site 1260251000043 active site 1260251000044 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1260251000045 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1260251000046 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1260251000047 dimer interface [polypeptide binding]; other site 1260251000048 motif 1; other site 1260251000049 active site 1260251000050 motif 2; other site 1260251000051 motif 3; other site 1260251000052 glutamine synthetase; Provisional; Region: glnA; PRK09469 1260251000053 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1260251000054 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1260251000055 PAS domain; Region: PAS; smart00091 1260251000056 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1260251000057 putative active site [active] 1260251000058 heme pocket [chemical binding]; other site 1260251000059 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1260251000060 dimer interface [polypeptide binding]; other site 1260251000061 phosphorylation site [posttranslational modification] 1260251000062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1260251000063 ATP binding site [chemical binding]; other site 1260251000064 Mg2+ binding site [ion binding]; other site 1260251000065 G-X-G motif; other site 1260251000066 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1260251000067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1260251000068 active site 1260251000069 phosphorylation site [posttranslational modification] 1260251000070 intermolecular recognition site; other site 1260251000071 dimerization interface [polypeptide binding]; other site 1260251000072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251000073 Walker A motif; other site 1260251000074 ATP binding site [chemical binding]; other site 1260251000075 Walker B motif; other site 1260251000076 arginine finger; other site 1260251000077 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1260251000078 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1260251000079 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1260251000080 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1260251000081 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1260251000082 preprotein translocase subunit SecB; Validated; Region: PRK05751 1260251000083 SecA binding site; other site 1260251000084 Preprotein binding site; other site 1260251000085 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1260251000086 active site residue [active] 1260251000087 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1260251000088 Peptidase family M23; Region: Peptidase_M23; pfam01551 1260251000089 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1260251000090 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1260251000091 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1260251000092 protein binding site [polypeptide binding]; other site 1260251000093 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1260251000094 Catalytic dyad [active] 1260251000095 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1260251000096 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1260251000097 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1260251000098 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1260251000099 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1260251000100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1260251000101 S-adenosylmethionine binding site [chemical binding]; other site 1260251000102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 1260251000103 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1260251000104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251000105 Walker A motif; other site 1260251000106 ATP binding site [chemical binding]; other site 1260251000107 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1260251000108 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1260251000109 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 1260251000110 active site 1260251000111 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1260251000112 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1260251000113 active site 1260251000114 DNA binding site [nucleotide binding] 1260251000115 Int/Topo IB signature motif; other site 1260251000116 Protein of unknown function, DUF484; Region: DUF484; cl17449 1260251000117 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1260251000118 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1260251000119 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1260251000120 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1260251000121 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1260251000122 active site 1260251000123 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1260251000124 substrate binding site [chemical binding]; other site 1260251000125 catalytic residues [active] 1260251000126 dimer interface [polypeptide binding]; other site 1260251000127 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 1260251000128 putative hydrolase; Provisional; Region: PRK11460 1260251000129 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1260251000130 argininosuccinate lyase; Provisional; Region: PRK00855 1260251000131 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1260251000132 active sites [active] 1260251000133 tetramer interface [polypeptide binding]; other site 1260251000134 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1260251000135 LytTr DNA-binding domain; Region: LytTR; pfam04397 1260251000136 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1260251000137 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1260251000138 domain interfaces; other site 1260251000139 active site 1260251000140 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1260251000141 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1260251000142 active site 1260251000143 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 1260251000144 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 1260251000145 HemY protein N-terminus; Region: HemY_N; pfam07219 1260251000146 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1260251000147 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1260251000148 NADP binding site [chemical binding]; other site 1260251000149 dimer interface [polypeptide binding]; other site 1260251000150 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1260251000151 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1260251000152 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1260251000153 putative NAD(P) binding site [chemical binding]; other site 1260251000154 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1260251000155 PGAP1-like protein; Region: PGAP1; pfam07819 1260251000156 acyl-CoA esterase; Provisional; Region: PRK10673 1260251000157 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1260251000158 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1260251000159 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1260251000160 dimer interface [polypeptide binding]; other site 1260251000161 active site 1260251000162 CoA binding pocket [chemical binding]; other site 1260251000163 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1260251000164 E3 interaction surface; other site 1260251000165 lipoyl attachment site [posttranslational modification]; other site 1260251000166 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1260251000167 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1260251000168 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1260251000169 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1260251000170 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1260251000171 E3 interaction surface; other site 1260251000172 lipoyl attachment site [posttranslational modification]; other site 1260251000173 e3 binding domain; Region: E3_binding; pfam02817 1260251000174 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1260251000175 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1260251000176 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1260251000177 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1260251000178 dimer interface [polypeptide binding]; other site 1260251000179 TPP-binding site [chemical binding]; other site 1260251000180 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1260251000181 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1260251000182 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1260251000183 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1260251000184 MoaE homodimer interface [polypeptide binding]; other site 1260251000185 MoaD interaction [polypeptide binding]; other site 1260251000186 active site residues [active] 1260251000187 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1260251000188 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1260251000189 FeS/SAM binding site; other site 1260251000190 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1260251000191 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1260251000192 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1260251000193 GTP binding site; other site 1260251000194 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1260251000195 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1260251000196 dimer interface [polypeptide binding]; other site 1260251000197 putative functional site; other site 1260251000198 putative MPT binding site; other site 1260251000199 Ubiquitin-like proteins; Region: UBQ; cl00155 1260251000200 charged pocket; other site 1260251000201 hydrophobic patch; other site 1260251000202 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 1260251000203 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1260251000204 Asp-box motif; other site 1260251000205 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1260251000206 DNA topoisomerase I; Provisional; Region: PRK08780 1260251000207 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1260251000208 active site 1260251000209 interdomain interaction site; other site 1260251000210 putative metal-binding site [ion binding]; other site 1260251000211 nucleotide binding site [chemical binding]; other site 1260251000212 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1260251000213 domain I; other site 1260251000214 phosphate binding site [ion binding]; other site 1260251000215 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1260251000216 domain II; other site 1260251000217 domain III; other site 1260251000218 nucleotide binding site [chemical binding]; other site 1260251000219 DNA binding groove [nucleotide binding] 1260251000220 catalytic site [active] 1260251000221 domain IV; other site 1260251000222 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1260251000223 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1260251000224 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1260251000225 Protein of unknown function (DUF494); Region: DUF494; pfam04361 1260251000226 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1260251000227 DNA protecting protein DprA; Region: dprA; TIGR00732 1260251000228 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1260251000229 active site 1260251000230 catalytic residues [active] 1260251000231 metal binding site [ion binding]; metal-binding site 1260251000232 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1260251000233 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1260251000234 putative active site [active] 1260251000235 substrate binding site [chemical binding]; other site 1260251000236 putative cosubstrate binding site; other site 1260251000237 catalytic site [active] 1260251000238 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1260251000239 substrate binding site [chemical binding]; other site 1260251000240 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1260251000241 putative RNA binding site [nucleotide binding]; other site 1260251000242 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1260251000243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1260251000244 S-adenosylmethionine binding site [chemical binding]; other site 1260251000245 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 1260251000246 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 1260251000247 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1260251000248 dimerization interface [polypeptide binding]; other site 1260251000249 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1260251000250 putative active site [active] 1260251000251 heme pocket [chemical binding]; other site 1260251000252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1260251000253 dimer interface [polypeptide binding]; other site 1260251000254 phosphorylation site [posttranslational modification] 1260251000255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1260251000256 ATP binding site [chemical binding]; other site 1260251000257 G-X-G motif; other site 1260251000258 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1260251000259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1260251000260 active site 1260251000261 phosphorylation site [posttranslational modification] 1260251000262 intermolecular recognition site; other site 1260251000263 dimerization interface [polypeptide binding]; other site 1260251000264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1260251000265 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1260251000266 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1260251000267 TrkA-N domain; Region: TrkA_N; pfam02254 1260251000268 TrkA-C domain; Region: TrkA_C; pfam02080 1260251000269 TrkA-N domain; Region: TrkA_N; pfam02254 1260251000270 TrkA-C domain; Region: TrkA_C; pfam02080 1260251000271 Cation transport protein; Region: TrkH; cl17365 1260251000272 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1260251000273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1260251000274 TPR motif; other site 1260251000275 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1260251000276 binding surface 1260251000277 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1260251000278 putative active site [active] 1260251000279 dimerization interface [polypeptide binding]; other site 1260251000280 putative tRNAtyr binding site [nucleotide binding]; other site 1260251000281 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1260251000282 putative active site pocket [active] 1260251000283 4-fold oligomerization interface [polypeptide binding]; other site 1260251000284 metal binding residues [ion binding]; metal-binding site 1260251000285 3-fold/trimer interface [polypeptide binding]; other site 1260251000286 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1260251000287 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1260251000288 putative active site [active] 1260251000289 oxyanion strand; other site 1260251000290 catalytic triad [active] 1260251000291 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1260251000292 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1260251000293 catalytic residues [active] 1260251000294 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1260251000295 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1260251000296 substrate binding site [chemical binding]; other site 1260251000297 glutamase interaction surface [polypeptide binding]; other site 1260251000298 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1260251000299 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1260251000300 metal binding site [ion binding]; metal-binding site 1260251000301 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1260251000302 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 1260251000303 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1260251000304 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1260251000305 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1260251000306 TPP-binding site [chemical binding]; other site 1260251000307 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1260251000308 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1260251000309 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1260251000310 E3 interaction surface; other site 1260251000311 lipoyl attachment site [posttranslational modification]; other site 1260251000312 e3 binding domain; Region: E3_binding; pfam02817 1260251000313 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1260251000314 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 1260251000315 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1260251000316 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1260251000317 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1260251000318 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1260251000319 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 1260251000320 dimer interface [polypeptide binding]; other site 1260251000321 active site 1260251000322 citrylCoA binding site [chemical binding]; other site 1260251000323 oxalacetate/citrate binding site [chemical binding]; other site 1260251000324 coenzyme A binding site [chemical binding]; other site 1260251000325 catalytic triad [active] 1260251000326 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1260251000327 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1260251000328 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1260251000329 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1260251000330 putative metal binding site [ion binding]; other site 1260251000331 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1260251000332 HSP70 interaction site [polypeptide binding]; other site 1260251000333 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1260251000334 YceI-like domain; Region: YceI; pfam04264 1260251000335 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1260251000336 LrgB-like family; Region: LrgB; pfam04172 1260251000337 LrgA family; Region: LrgA; pfam03788 1260251000338 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1260251000339 HSP70 interaction site [polypeptide binding]; other site 1260251000340 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1260251000341 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1260251000342 hypothetical protein; Validated; Region: PRK09039 1260251000343 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1260251000344 ligand binding site [chemical binding]; other site 1260251000345 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1260251000346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1260251000347 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1260251000348 dimerization interface [polypeptide binding]; other site 1260251000349 isocitrate lyase; Provisional; Region: PRK15063 1260251000350 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1260251000351 tetramer interface [polypeptide binding]; other site 1260251000352 active site 1260251000353 Mg2+/Mn2+ binding site [ion binding]; other site 1260251000354 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1260251000355 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1260251000356 tetramer interface [polypeptide binding]; other site 1260251000357 active site 1260251000358 Mg2+/Mn2+ binding site [ion binding]; other site 1260251000359 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1260251000360 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1260251000361 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1260251000362 Sodium Bile acid symporter family; Region: SBF; cl17470 1260251000363 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1260251000364 dimerization interface [polypeptide binding]; other site 1260251000365 putative DNA binding site [nucleotide binding]; other site 1260251000366 putative Zn2+ binding site [ion binding]; other site 1260251000367 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1260251000368 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1260251000369 active site 1260251000370 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1260251000371 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1260251000372 putative DNA binding site [nucleotide binding]; other site 1260251000373 putative Zn2+ binding site [ion binding]; other site 1260251000374 AsnC family; Region: AsnC_trans_reg; pfam01037 1260251000375 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 1260251000376 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1260251000377 dimer interface [polypeptide binding]; other site 1260251000378 TPP-binding site [chemical binding]; other site 1260251000379 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1260251000380 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1260251000381 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 1260251000382 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1260251000383 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 1260251000384 Predicted membrane protein [Function unknown]; Region: COG2860 1260251000385 UPF0126 domain; Region: UPF0126; pfam03458 1260251000386 UPF0126 domain; Region: UPF0126; pfam03458 1260251000387 Gram-negative porin; Region: Porin_4; pfam13609 1260251000388 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1260251000389 classical (c) SDRs; Region: SDR_c; cd05233 1260251000390 NAD(P) binding site [chemical binding]; other site 1260251000391 active site 1260251000392 Putative transcription activator [Transcription]; Region: TenA; COG0819 1260251000393 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1260251000394 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1260251000395 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1260251000396 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1260251000397 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1260251000398 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1260251000399 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1260251000400 DNA binding residues [nucleotide binding] 1260251000401 DNA primase; Validated; Region: dnaG; PRK05667 1260251000402 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1260251000403 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1260251000404 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1260251000405 active site 1260251000406 metal binding site [ion binding]; metal-binding site 1260251000407 interdomain interaction site; other site 1260251000408 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1260251000409 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1260251000410 Yqey-like protein; Region: YqeY; pfam09424 1260251000411 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1260251000412 UGMP family protein; Validated; Region: PRK09604 1260251000413 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1260251000414 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1260251000415 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1260251000416 Dihydroneopterin aldolase; Region: FolB; smart00905 1260251000417 active site 1260251000418 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1260251000419 catalytic center binding site [active] 1260251000420 ATP binding site [chemical binding]; other site 1260251000421 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1260251000422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1260251000423 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1260251000424 cyclase homology domain; Region: CHD; cd07302 1260251000425 nucleotidyl binding site; other site 1260251000426 metal binding site [ion binding]; metal-binding site 1260251000427 dimer interface [polypeptide binding]; other site 1260251000428 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1260251000429 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1260251000430 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1260251000431 active site 1260251000432 NTP binding site [chemical binding]; other site 1260251000433 metal binding triad [ion binding]; metal-binding site 1260251000434 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1260251000435 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1260251000436 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1260251000437 putative NAD(P) binding site [chemical binding]; other site 1260251000438 active site 1260251000439 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1260251000440 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1260251000441 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1260251000442 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1260251000443 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1260251000444 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1260251000445 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1260251000446 carboxyltransferase (CT) interaction site; other site 1260251000447 biotinylation site [posttranslational modification]; other site 1260251000448 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1260251000449 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1260251000450 trimer interface [polypeptide binding]; other site 1260251000451 active site 1260251000452 dimer interface [polypeptide binding]; other site 1260251000453 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1260251000454 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1260251000455 catalytic residues [active] 1260251000456 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1260251000457 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1260251000458 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1260251000459 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1260251000460 DsbD alpha interface [polypeptide binding]; other site 1260251000461 catalytic residues [active] 1260251000462 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 1260251000463 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1260251000464 oligomerisation interface [polypeptide binding]; other site 1260251000465 mobile loop; other site 1260251000466 roof hairpin; other site 1260251000467 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1260251000468 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1260251000469 ring oligomerisation interface [polypeptide binding]; other site 1260251000470 ATP/Mg binding site [chemical binding]; other site 1260251000471 stacking interactions; other site 1260251000472 hinge regions; other site 1260251000473 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1260251000474 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1260251000475 metal binding triad; other site 1260251000476 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1260251000477 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1260251000478 metal binding triad; other site 1260251000479 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1260251000480 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1260251000481 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1260251000482 homodimer interface [polypeptide binding]; other site 1260251000483 substrate-cofactor binding pocket; other site 1260251000484 catalytic residue [active] 1260251000485 Zinc-finger domain; Region: zf-CHCC; cl01821 1260251000486 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1260251000487 putative acyl-acceptor binding pocket; other site 1260251000488 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1260251000489 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1260251000490 active site 1260251000491 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1260251000492 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1260251000493 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 1260251000494 Substrate binding site; other site 1260251000495 metal-binding site 1260251000496 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1260251000497 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1260251000498 putative acyl-acceptor binding pocket; other site 1260251000499 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 1260251000500 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1260251000501 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1260251000502 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1260251000503 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1260251000504 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1260251000505 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1260251000506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1260251000507 S-adenosylmethionine binding site [chemical binding]; other site 1260251000508 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1260251000509 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1260251000510 HSP70 interaction site [polypeptide binding]; other site 1260251000511 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1260251000512 substrate binding site [polypeptide binding]; other site 1260251000513 dimer interface [polypeptide binding]; other site 1260251000514 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1260251000515 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1260251000516 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1260251000517 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1260251000518 DNA binding site [nucleotide binding] 1260251000519 catalytic residue [active] 1260251000520 H2TH interface [polypeptide binding]; other site 1260251000521 putative catalytic residues [active] 1260251000522 turnover-facilitating residue; other site 1260251000523 intercalation triad [nucleotide binding]; other site 1260251000524 8OG recognition residue [nucleotide binding]; other site 1260251000525 putative reading head residues; other site 1260251000526 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1260251000527 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1260251000528 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1260251000529 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1260251000530 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1260251000531 tartrate dehydrogenase; Region: TTC; TIGR02089 1260251000532 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1260251000533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1260251000534 Walker A/P-loop; other site 1260251000535 ATP binding site [chemical binding]; other site 1260251000536 Q-loop/lid; other site 1260251000537 ABC transporter signature motif; other site 1260251000538 Walker B; other site 1260251000539 D-loop; other site 1260251000540 H-loop/switch region; other site 1260251000541 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1260251000542 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1260251000543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1260251000544 Walker A/P-loop; other site 1260251000545 ATP binding site [chemical binding]; other site 1260251000546 Q-loop/lid; other site 1260251000547 ABC transporter signature motif; other site 1260251000548 Walker B; other site 1260251000549 D-loop; other site 1260251000550 H-loop/switch region; other site 1260251000551 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1260251000552 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1260251000553 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1260251000554 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1260251000555 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1260251000556 ligand binding site [chemical binding]; other site 1260251000557 flexible hinge region; other site 1260251000558 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1260251000559 putative switch regulator; other site 1260251000560 non-specific DNA interactions [nucleotide binding]; other site 1260251000561 DNA binding site [nucleotide binding] 1260251000562 sequence specific DNA binding site [nucleotide binding]; other site 1260251000563 putative cAMP binding site [chemical binding]; other site 1260251000564 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1260251000565 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1260251000566 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1260251000567 active site residue [active] 1260251000568 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1260251000569 active site residue [active] 1260251000570 ferrochelatase; Reviewed; Region: hemH; PRK00035 1260251000571 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1260251000572 C-terminal domain interface [polypeptide binding]; other site 1260251000573 active site 1260251000574 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1260251000575 active site 1260251000576 N-terminal domain interface [polypeptide binding]; other site 1260251000577 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 1260251000578 Protein of unknown function DUF45; Region: DUF45; pfam01863 1260251000579 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1260251000580 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1260251000581 Protein of unknown function (DUF938); Region: DUF938; pfam06080 1260251000582 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1260251000583 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1260251000584 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1260251000585 putative NAD(P) binding site [chemical binding]; other site 1260251000586 Protein of unknown function (DUF3726); Region: DUF3726; pfam12525 1260251000587 potential frameshift: common BLAST hit: gi|307544333|ref|YP_003896812.1| BCCT family protein 1260251000588 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1260251000589 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1260251000590 active site 1260251000591 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1260251000592 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1260251000593 NAD(P) binding site [chemical binding]; other site 1260251000594 catalytic residues [active] 1260251000595 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1260251000596 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1260251000597 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1260251000598 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1260251000599 [4Fe-4S] binding site [ion binding]; other site 1260251000600 molybdopterin cofactor binding site; other site 1260251000601 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1260251000602 molybdopterin cofactor binding site; other site 1260251000603 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 1260251000604 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1260251000605 catalytic loop [active] 1260251000606 iron binding site [ion binding]; other site 1260251000607 4Fe-4S binding domain; Region: Fer4; pfam00037 1260251000608 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1260251000609 putative dimer interface [polypeptide binding]; other site 1260251000610 [2Fe-2S] cluster binding site [ion binding]; other site 1260251000611 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1260251000612 SLBB domain; Region: SLBB; pfam10531 1260251000613 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1260251000614 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1260251000615 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1260251000616 Potassium binding sites [ion binding]; other site 1260251000617 Cesium cation binding sites [ion binding]; other site 1260251000618 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1260251000619 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1260251000620 conserved cys residue [active] 1260251000621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1260251000622 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1260251000623 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1260251000624 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1260251000625 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1260251000626 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1260251000627 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1260251000628 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 1260251000629 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1260251000630 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1260251000631 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1260251000632 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1260251000633 FAD binding site [chemical binding]; other site 1260251000634 LysE type translocator; Region: LysE; cl00565 1260251000635 Domain of unknown function (DUF3524); Region: DUF3524; pfam12038 1260251000636 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1260251000637 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1260251000638 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1260251000639 Peptidase family M23; Region: Peptidase_M23; pfam01551 1260251000640 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1260251000641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1260251000642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1260251000643 ATP binding site [chemical binding]; other site 1260251000644 Mg2+ binding site [ion binding]; other site 1260251000645 G-X-G motif; other site 1260251000646 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1260251000647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1260251000648 active site 1260251000649 phosphorylation site [posttranslational modification] 1260251000650 intermolecular recognition site; other site 1260251000651 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1260251000652 DNA binding residues [nucleotide binding] 1260251000653 oxidative damage protection protein; Provisional; Region: PRK05408 1260251000654 adenine DNA glycosylase; Provisional; Region: PRK10880 1260251000655 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1260251000656 minor groove reading motif; other site 1260251000657 helix-hairpin-helix signature motif; other site 1260251000658 substrate binding pocket [chemical binding]; other site 1260251000659 active site 1260251000660 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1260251000661 DNA binding and oxoG recognition site [nucleotide binding] 1260251000662 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1260251000663 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1260251000664 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1260251000665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1260251000666 putative PBP binding loops; other site 1260251000667 dimer interface [polypeptide binding]; other site 1260251000668 ABC-ATPase subunit interface; other site 1260251000669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1260251000670 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 1260251000671 Walker A/P-loop; other site 1260251000672 ATP binding site [chemical binding]; other site 1260251000673 Q-loop/lid; other site 1260251000674 ABC transporter signature motif; other site 1260251000675 Walker B; other site 1260251000676 D-loop; other site 1260251000677 H-loop/switch region; other site 1260251000678 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1260251000679 thiS-thiF/thiG interaction site; other site 1260251000680 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1260251000681 ThiS interaction site; other site 1260251000682 putative active site [active] 1260251000683 tetramer interface [polypeptide binding]; other site 1260251000684 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1260251000685 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1260251000686 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1260251000687 N-terminal plug; other site 1260251000688 ligand-binding site [chemical binding]; other site 1260251000689 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1260251000690 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1260251000691 intersubunit interface [polypeptide binding]; other site 1260251000692 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1260251000693 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1260251000694 putative PBP binding regions; other site 1260251000695 ABC-ATPase subunit interface; other site 1260251000696 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1260251000697 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1260251000698 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1260251000699 putative active site [active] 1260251000700 putative catalytic site [active] 1260251000701 putative DNA binding site [nucleotide binding]; other site 1260251000702 putative phosphate binding site [ion binding]; other site 1260251000703 metal binding site A [ion binding]; metal-binding site 1260251000704 putative AP binding site [nucleotide binding]; other site 1260251000705 putative metal binding site B [ion binding]; other site 1260251000706 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 1260251000707 thioredoxin reductase; Provisional; Region: PRK10262 1260251000708 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1260251000709 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1260251000710 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1260251000711 muropeptide transporter; Validated; Region: ampG; cl17669 1260251000712 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1260251000713 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1260251000714 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1260251000715 active site 1260251000716 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1260251000717 feedback inhibition sensing region; other site 1260251000718 homohexameric interface [polypeptide binding]; other site 1260251000719 nucleotide binding site [chemical binding]; other site 1260251000720 N-acetyl-L-glutamate binding site [chemical binding]; other site 1260251000721 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1260251000722 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1260251000723 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1260251000724 active site 1260251000725 substrate binding site [chemical binding]; other site 1260251000726 metal binding site [ion binding]; metal-binding site 1260251000727 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1260251000728 trimer interface [polypeptide binding]; other site 1260251000729 active site 1260251000730 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1260251000731 Flavoprotein; Region: Flavoprotein; pfam02441 1260251000732 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1260251000733 hypothetical protein; Reviewed; Region: PRK00024 1260251000734 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1260251000735 MPN+ (JAMM) motif; other site 1260251000736 Zinc-binding site [ion binding]; other site 1260251000737 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1260251000738 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1260251000739 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1260251000740 DNA binding residues [nucleotide binding] 1260251000741 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1260251000742 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1260251000743 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1260251000744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1260251000745 Walker A/P-loop; other site 1260251000746 ATP binding site [chemical binding]; other site 1260251000747 Q-loop/lid; other site 1260251000748 ABC transporter signature motif; other site 1260251000749 Walker B; other site 1260251000750 D-loop; other site 1260251000751 H-loop/switch region; other site 1260251000752 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1260251000753 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1260251000754 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1260251000755 P loop; other site 1260251000756 GTP binding site [chemical binding]; other site 1260251000757 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1260251000758 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1260251000759 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1260251000760 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1260251000761 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1260251000762 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1260251000763 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1260251000764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1260251000765 S-adenosylmethionine binding site [chemical binding]; other site 1260251000766 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1260251000767 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1260251000768 active site 1260251000769 (T/H)XGH motif; other site 1260251000770 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1260251000771 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1260251000772 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1260251000773 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1260251000774 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1260251000775 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1260251000776 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 1260251000777 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1260251000778 ATP-grasp domain; Region: ATP-grasp; pfam02222 1260251000779 Putative exonuclease, RdgC; Region: RdgC; pfam04381 1260251000780 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1260251000781 putative active site [active] 1260251000782 putative metal binding site [ion binding]; other site 1260251000783 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1260251000784 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1260251000785 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 1260251000786 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1260251000787 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1260251000788 DctM-like transporters; Region: DctM; pfam06808 1260251000789 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1260251000790 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1260251000791 Bacterial transcriptional regulator; Region: IclR; pfam01614 1260251000792 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1260251000793 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1260251000794 active site 1260251000795 Zn binding site [ion binding]; other site 1260251000796 Cytochrome c; Region: Cytochrom_C; cl11414 1260251000797 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1260251000798 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1260251000799 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1260251000800 TrkA-N domain; Region: TrkA_N; pfam02254 1260251000801 TrkA-C domain; Region: TrkA_C; pfam02080 1260251000802 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1260251000803 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1260251000804 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1260251000805 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1260251000806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251000807 Walker A motif; other site 1260251000808 ATP binding site [chemical binding]; other site 1260251000809 Walker B motif; other site 1260251000810 arginine finger; other site 1260251000811 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1260251000812 Membrane fusogenic activity; Region: BMFP; pfam04380 1260251000813 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1260251000814 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1260251000815 probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644 1260251000816 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1260251000817 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1260251000818 Sporulation related domain; Region: SPOR; pfam05036 1260251000819 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1260251000820 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1260251000821 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1260251000822 active site 1260251000823 HIGH motif; other site 1260251000824 nucleotide binding site [chemical binding]; other site 1260251000825 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1260251000826 KMSK motif region; other site 1260251000827 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1260251000828 tRNA binding surface [nucleotide binding]; other site 1260251000829 anticodon binding site; other site 1260251000830 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1260251000831 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1260251000832 ATP binding site [chemical binding]; other site 1260251000833 putative Mg++ binding site [ion binding]; other site 1260251000834 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 1260251000835 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1260251000836 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1260251000837 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1260251000838 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1260251000839 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1260251000840 ligand binding site [chemical binding]; other site 1260251000841 homodimer interface [polypeptide binding]; other site 1260251000842 NAD(P) binding site [chemical binding]; other site 1260251000843 trimer interface B [polypeptide binding]; other site 1260251000844 trimer interface A [polypeptide binding]; other site 1260251000845 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1260251000846 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1260251000847 active site 1260251000848 VacJ like lipoprotein; Region: VacJ; cl01073 1260251000849 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1260251000850 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1260251000851 catalytic loop [active] 1260251000852 iron binding site [ion binding]; other site 1260251000853 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1260251000854 FAD binding pocket [chemical binding]; other site 1260251000855 FAD binding motif [chemical binding]; other site 1260251000856 phosphate binding motif [ion binding]; other site 1260251000857 beta-alpha-beta structure motif; other site 1260251000858 NAD binding pocket [chemical binding]; other site 1260251000859 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1260251000860 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1260251000861 putative catalytic site [active] 1260251000862 putative phosphate binding site [ion binding]; other site 1260251000863 active site 1260251000864 metal binding site A [ion binding]; metal-binding site 1260251000865 DNA binding site [nucleotide binding] 1260251000866 putative AP binding site [nucleotide binding]; other site 1260251000867 putative metal binding site B [ion binding]; other site 1260251000868 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1260251000869 Methyltransferase domain; Region: Methyltransf_25; pfam13649 1260251000870 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1260251000871 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1260251000872 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1260251000873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1260251000874 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1260251000875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1260251000876 Walker A/P-loop; other site 1260251000877 ATP binding site [chemical binding]; other site 1260251000878 Q-loop/lid; other site 1260251000879 ABC transporter signature motif; other site 1260251000880 Walker B; other site 1260251000881 D-loop; other site 1260251000882 H-loop/switch region; other site 1260251000883 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1260251000884 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1260251000885 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1260251000886 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1260251000887 putative glycosyltransferase, TIGR04348 family; Region: TIGR04348 1260251000888 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1260251000889 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 1260251000890 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1260251000891 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 1260251000892 dimerization interface [polypeptide binding]; other site 1260251000893 putative ATP binding site [chemical binding]; other site 1260251000894 oligopeptidase A; Provisional; Region: PRK10911 1260251000895 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1260251000896 active site 1260251000897 Zn binding site [ion binding]; other site 1260251000898 glutathione reductase; Validated; Region: PRK06116 1260251000899 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1260251000900 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1260251000901 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1260251000902 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1260251000903 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1260251000904 trimer interface [polypeptide binding]; other site 1260251000905 putative metal binding site [ion binding]; other site 1260251000906 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1260251000907 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1260251000908 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1260251000909 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1260251000910 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1260251000911 shikimate binding site; other site 1260251000912 NAD(P) binding site [chemical binding]; other site 1260251000913 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1260251000914 dimer interface [polypeptide binding]; other site 1260251000915 active site 1260251000916 aspartate-rich active site metal binding site; other site 1260251000917 allosteric magnesium binding site [ion binding]; other site 1260251000918 Schiff base residues; other site 1260251000919 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 1260251000920 active site 1260251000921 Ap4A binding cleft/pocket [chemical binding]; other site 1260251000922 P4 phosphate binding site; other site 1260251000923 nudix motif; other site 1260251000924 putative P2/P3 phosphate binding site [ion binding]; other site 1260251000925 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1260251000926 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1260251000927 substrate binding site [chemical binding]; other site 1260251000928 active site 1260251000929 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1260251000930 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1260251000931 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1260251000932 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1260251000933 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1260251000934 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1260251000935 active site 1260251000936 dimer interface [polypeptide binding]; other site 1260251000937 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1260251000938 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1260251000939 active site 1260251000940 FMN binding site [chemical binding]; other site 1260251000941 substrate binding site [chemical binding]; other site 1260251000942 3Fe-4S cluster binding site [ion binding]; other site 1260251000943 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1260251000944 domain interface; other site 1260251000945 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1260251000946 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1260251000947 Zn2+ binding site [ion binding]; other site 1260251000948 Mg2+ binding site [ion binding]; other site 1260251000949 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1260251000950 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1260251000951 active site 1260251000952 dimer interface [polypeptide binding]; other site 1260251000953 metal binding site [ion binding]; metal-binding site 1260251000954 shikimate kinase; Reviewed; Region: aroK; PRK00131 1260251000955 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1260251000956 ADP binding site [chemical binding]; other site 1260251000957 magnesium binding site [ion binding]; other site 1260251000958 putative shikimate binding site; other site 1260251000959 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1260251000960 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 1260251000961 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1260251000962 Pilus assembly protein, PilO; Region: PilO; cl01234 1260251000963 Pilus assembly protein, PilP; Region: PilP; pfam04351 1260251000964 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1260251000965 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1260251000966 Cell division protein FtsA; Region: FtsA; cl17206 1260251000967 Competence protein A; Region: Competence_A; pfam11104 1260251000968 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1260251000969 Transglycosylase; Region: Transgly; pfam00912 1260251000970 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1260251000971 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1260251000972 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1260251000973 dimer interface [polypeptide binding]; other site 1260251000974 active site 1260251000975 citrylCoA binding site [chemical binding]; other site 1260251000976 NADH binding [chemical binding]; other site 1260251000977 cationic pore residues; other site 1260251000978 oxalacetate/citrate binding site [chemical binding]; other site 1260251000979 coenzyme A binding site [chemical binding]; other site 1260251000980 catalytic triad [active] 1260251000981 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1260251000982 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 1260251000983 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 1260251000984 HemN family oxidoreductase; Provisional; Region: PRK05660 1260251000985 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1260251000986 FeS/SAM binding site; other site 1260251000987 HemN C-terminal domain; Region: HemN_C; pfam06969 1260251000988 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1260251000989 active site 1260251000990 dimerization interface [polypeptide binding]; other site 1260251000991 ribonuclease PH; Reviewed; Region: rph; PRK00173 1260251000992 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1260251000993 hexamer interface [polypeptide binding]; other site 1260251000994 active site 1260251000995 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1260251000996 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1260251000997 catalytic site [active] 1260251000998 G-X2-G-X-G-K; other site 1260251000999 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1260251001000 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1260251001001 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1260251001002 Zn2+ binding site [ion binding]; other site 1260251001003 Mg2+ binding site [ion binding]; other site 1260251001004 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1260251001005 synthetase active site [active] 1260251001006 NTP binding site [chemical binding]; other site 1260251001007 metal binding site [ion binding]; metal-binding site 1260251001008 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1260251001009 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1260251001010 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1260251001011 homotrimer interaction site [polypeptide binding]; other site 1260251001012 putative active site [active] 1260251001013 Pathogenicity locus; Region: Cdd1; pfam11731 1260251001014 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1260251001015 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1260251001016 ssDNA binding site; other site 1260251001017 generic binding surface II; other site 1260251001018 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1260251001019 ATP binding site [chemical binding]; other site 1260251001020 putative Mg++ binding site [ion binding]; other site 1260251001021 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1260251001022 nucleotide binding region [chemical binding]; other site 1260251001023 ATP-binding site [chemical binding]; other site 1260251001024 Chorismate lyase; Region: Chor_lyase; cl01230 1260251001025 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1260251001026 UbiA prenyltransferase family; Region: UbiA; pfam01040 1260251001027 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1260251001028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1260251001029 active site 1260251001030 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1260251001031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1260251001032 S-adenosylmethionine binding site [chemical binding]; other site 1260251001033 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 1260251001034 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1260251001035 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1260251001036 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1260251001037 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1260251001038 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1260251001039 Subunit I/III interface [polypeptide binding]; other site 1260251001040 D-pathway; other site 1260251001041 Subunit I/VIIc interface [polypeptide binding]; other site 1260251001042 Subunit I/IV interface [polypeptide binding]; other site 1260251001043 Subunit I/II interface [polypeptide binding]; other site 1260251001044 Low-spin heme (heme a) binding site [chemical binding]; other site 1260251001045 Subunit I/VIIa interface [polypeptide binding]; other site 1260251001046 Subunit I/VIa interface [polypeptide binding]; other site 1260251001047 Dimer interface; other site 1260251001048 Putative water exit pathway; other site 1260251001049 Binuclear center (heme a3/CuB) [ion binding]; other site 1260251001050 K-pathway; other site 1260251001051 Subunit I/Vb interface [polypeptide binding]; other site 1260251001052 Putative proton exit pathway; other site 1260251001053 Subunit I/VIb interface; other site 1260251001054 Subunit I/VIc interface [polypeptide binding]; other site 1260251001055 Electron transfer pathway; other site 1260251001056 Subunit I/VIIIb interface [polypeptide binding]; other site 1260251001057 Subunit I/VIIb interface [polypeptide binding]; other site 1260251001058 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1260251001059 Subunit III/VIIa interface [polypeptide binding]; other site 1260251001060 Phospholipid binding site [chemical binding]; other site 1260251001061 Subunit I/III interface [polypeptide binding]; other site 1260251001062 Subunit III/VIb interface [polypeptide binding]; other site 1260251001063 Subunit III/VIa interface; other site 1260251001064 Subunit III/Vb interface [polypeptide binding]; other site 1260251001065 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 1260251001066 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1260251001067 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1260251001068 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1260251001069 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1260251001070 UbiA prenyltransferase family; Region: UbiA; pfam01040 1260251001071 lipoyl synthase; Provisional; Region: PRK05481 1260251001072 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1260251001073 FeS/SAM binding site; other site 1260251001074 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1260251001075 CPxP motif; other site 1260251001076 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1260251001077 putative inner membrane peptidase; Provisional; Region: PRK11778 1260251001078 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1260251001079 tandem repeat interface [polypeptide binding]; other site 1260251001080 oligomer interface [polypeptide binding]; other site 1260251001081 active site residues [active] 1260251001082 ORF6N domain; Region: ORF6N; pfam10543 1260251001083 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1260251001084 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1260251001085 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1260251001086 Cu(I) binding site [ion binding]; other site 1260251001087 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1260251001088 Predicted ATPase [General function prediction only]; Region: COG1485 1260251001089 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1260251001090 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1260251001091 putative active site [active] 1260251001092 Zn binding site [ion binding]; other site 1260251001093 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 1260251001094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1260251001095 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1260251001096 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1260251001097 YGGT family; Region: YGGT; pfam02325 1260251001098 YGGT family; Region: YGGT; pfam02325 1260251001099 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1260251001100 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1260251001101 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1260251001102 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1260251001103 catalytic residue [active] 1260251001104 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1260251001105 dihydroorotase; Provisional; Region: PRK07627 1260251001106 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1260251001107 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1260251001108 active site 1260251001109 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1260251001110 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1260251001111 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1260251001112 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1260251001113 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1260251001114 active site 1260251001115 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1260251001116 glutathione synthetase; Provisional; Region: PRK05246 1260251001117 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1260251001118 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1260251001119 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1260251001120 RNA methyltransferase, RsmE family; Region: TIGR00046 1260251001121 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1260251001122 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1260251001123 homotetramer interface [polypeptide binding]; other site 1260251001124 ligand binding site [chemical binding]; other site 1260251001125 catalytic site [active] 1260251001126 NAD binding site [chemical binding]; other site 1260251001127 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1260251001128 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1260251001129 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1260251001130 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1260251001131 transketolase; Reviewed; Region: PRK12753 1260251001132 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1260251001133 TPP-binding site [chemical binding]; other site 1260251001134 dimer interface [polypeptide binding]; other site 1260251001135 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1260251001136 PYR/PP interface [polypeptide binding]; other site 1260251001137 dimer interface [polypeptide binding]; other site 1260251001138 TPP binding site [chemical binding]; other site 1260251001139 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1260251001140 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1260251001141 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1260251001142 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1260251001143 Phosphoglycerate kinase; Region: PGK; pfam00162 1260251001144 substrate binding site [chemical binding]; other site 1260251001145 hinge regions; other site 1260251001146 ADP binding site [chemical binding]; other site 1260251001147 catalytic site [active] 1260251001148 pyruvate kinase; Provisional; Region: PRK05826 1260251001149 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1260251001150 domain interfaces; other site 1260251001151 active site 1260251001152 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1260251001153 ATP binding site [chemical binding]; other site 1260251001154 active site 1260251001155 substrate binding site [chemical binding]; other site 1260251001156 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1260251001157 DNA photolyase; Region: DNA_photolyase; pfam00875 1260251001158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1260251001159 short chain dehydrogenase; Provisional; Region: PRK07024 1260251001160 NAD(P) binding site [chemical binding]; other site 1260251001161 active site 1260251001162 SnoaL-like domain; Region: SnoaL_2; pfam12680 1260251001163 MFS/sugar transport protein; Region: MFS_2; pfam13347 1260251001164 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1260251001165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1260251001166 putative substrate translocation pore; other site 1260251001167 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1260251001168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1260251001169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1260251001170 S-adenosylmethionine binding site [chemical binding]; other site 1260251001171 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1260251001172 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1260251001173 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1260251001174 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1260251001175 MPT binding site; other site 1260251001176 trimer interface [polypeptide binding]; other site 1260251001177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1260251001178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1260251001179 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1260251001180 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1260251001181 substrate binding site [chemical binding]; other site 1260251001182 hexamer interface [polypeptide binding]; other site 1260251001183 metal binding site [ion binding]; metal-binding site 1260251001184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1260251001185 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 1260251001186 motif I; other site 1260251001187 active site 1260251001188 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1260251001189 motif II; other site 1260251001190 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1260251001191 anthranilate synthase component I; Provisional; Region: PRK13565 1260251001192 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1260251001193 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1260251001194 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1260251001195 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1260251001196 glutamine binding [chemical binding]; other site 1260251001197 catalytic triad [active] 1260251001198 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1260251001199 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1260251001200 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1260251001201 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1260251001202 active site 1260251001203 ribulose/triose binding site [chemical binding]; other site 1260251001204 phosphate binding site [ion binding]; other site 1260251001205 substrate (anthranilate) binding pocket [chemical binding]; other site 1260251001206 product (indole) binding pocket [chemical binding]; other site 1260251001207 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1260251001208 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1260251001209 ligand binding site [chemical binding]; other site 1260251001210 flexible hinge region; other site 1260251001211 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1260251001212 putative switch regulator; other site 1260251001213 non-specific DNA interactions [nucleotide binding]; other site 1260251001214 DNA binding site [nucleotide binding] 1260251001215 sequence specific DNA binding site [nucleotide binding]; other site 1260251001216 putative cAMP binding site [chemical binding]; other site 1260251001217 OsmC-like protein; Region: OsmC; cl00767 1260251001218 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1260251001219 23S rRNA interface [nucleotide binding]; other site 1260251001220 L3 interface [polypeptide binding]; other site 1260251001221 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1260251001222 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1260251001223 MoaE interaction surface [polypeptide binding]; other site 1260251001224 MoeB interaction surface [polypeptide binding]; other site 1260251001225 thiocarboxylated glycine; other site 1260251001226 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1260251001227 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1260251001228 ATP binding site [chemical binding]; other site 1260251001229 putative Mg++ binding site [ion binding]; other site 1260251001230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1260251001231 nucleotide binding region [chemical binding]; other site 1260251001232 ATP-binding site [chemical binding]; other site 1260251001233 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1260251001234 EamA-like transporter family; Region: EamA; pfam00892 1260251001235 EamA-like transporter family; Region: EamA; pfam00892 1260251001236 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 1260251001237 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1260251001238 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1260251001239 nudix motif; other site 1260251001240 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1260251001241 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1260251001242 Walker A/P-loop; other site 1260251001243 ATP binding site [chemical binding]; other site 1260251001244 Q-loop/lid; other site 1260251001245 ABC transporter signature motif; other site 1260251001246 Walker B; other site 1260251001247 D-loop; other site 1260251001248 H-loop/switch region; other site 1260251001249 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1260251001250 FtsX-like permease family; Region: FtsX; pfam02687 1260251001251 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1260251001252 FtsX-like permease family; Region: FtsX; pfam02687 1260251001253 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 1260251001254 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1260251001255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1260251001256 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1260251001257 putative substrate translocation pore; other site 1260251001258 NAD-dependent deacetylase; Provisional; Region: PRK05333 1260251001259 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1260251001260 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 1260251001261 DNA photolyase; Region: DNA_photolyase; pfam00875 1260251001262 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 1260251001263 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1260251001264 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1260251001265 trimer interface [polypeptide binding]; other site 1260251001266 eyelet of channel; other site 1260251001267 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1260251001268 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1260251001269 catalytic residues [active] 1260251001270 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1260251001271 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1260251001272 amidase catalytic site [active] 1260251001273 Zn binding residues [ion binding]; other site 1260251001274 substrate binding site [chemical binding]; other site 1260251001275 CobD/Cbib protein; Region: CobD_Cbib; cl00561 1260251001276 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1260251001277 Ligand Binding Site [chemical binding]; other site 1260251001278 DctM-like transporters; Region: DctM; pfam06808 1260251001279 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1260251001280 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1260251001281 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1260251001282 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1260251001283 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1260251001284 Pilin (bacterial filament); Region: Pilin; pfam00114 1260251001285 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1260251001286 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1260251001287 CoA-ligase; Region: Ligase_CoA; pfam00549 1260251001288 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1260251001289 CoA binding domain; Region: CoA_binding; smart00881 1260251001290 CoA-ligase; Region: Ligase_CoA; pfam00549 1260251001291 NAD synthetase; Provisional; Region: PRK13981 1260251001292 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1260251001293 multimer interface [polypeptide binding]; other site 1260251001294 active site 1260251001295 catalytic triad [active] 1260251001296 protein interface 1 [polypeptide binding]; other site 1260251001297 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1260251001298 homodimer interface [polypeptide binding]; other site 1260251001299 NAD binding pocket [chemical binding]; other site 1260251001300 ATP binding pocket [chemical binding]; other site 1260251001301 Mg binding site [ion binding]; other site 1260251001302 active-site loop [active] 1260251001303 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1260251001304 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1260251001305 Outer membrane lipoprotein; Region: YfiO; pfam13525 1260251001306 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1260251001307 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1260251001308 RNA binding surface [nucleotide binding]; other site 1260251001309 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1260251001310 active site 1260251001311 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1260251001312 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1260251001313 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1260251001314 Clp amino terminal domain; Region: Clp_N; pfam02861 1260251001315 Clp amino terminal domain; Region: Clp_N; pfam02861 1260251001316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251001317 Walker A motif; other site 1260251001318 ATP binding site [chemical binding]; other site 1260251001319 Walker B motif; other site 1260251001320 arginine finger; other site 1260251001321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251001322 Walker A motif; other site 1260251001323 ATP binding site [chemical binding]; other site 1260251001324 Walker B motif; other site 1260251001325 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1260251001326 short chain dehydrogenase; Provisional; Region: PRK05993 1260251001327 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1260251001328 NADP binding site [chemical binding]; other site 1260251001329 active site 1260251001330 steroid binding site; other site 1260251001331 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1260251001332 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1260251001333 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1260251001334 active site 1260251001335 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 1260251001336 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1260251001337 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1260251001338 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1260251001339 dimer interface [polypeptide binding]; other site 1260251001340 anticodon binding site; other site 1260251001341 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1260251001342 homodimer interface [polypeptide binding]; other site 1260251001343 motif 1; other site 1260251001344 active site 1260251001345 motif 2; other site 1260251001346 GAD domain; Region: GAD; pfam02938 1260251001347 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1260251001348 motif 3; other site 1260251001349 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1260251001350 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1260251001351 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1260251001352 Ferritin-like domain; Region: Ferritin; pfam00210 1260251001353 dimerization interface [polypeptide binding]; other site 1260251001354 DPS ferroxidase diiron center [ion binding]; other site 1260251001355 ion pore; other site 1260251001356 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1260251001357 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1260251001358 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1260251001359 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1260251001360 putative active site [active] 1260251001361 putative metal binding site [ion binding]; other site 1260251001362 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1260251001363 potential frameshift: common BLAST hit: gi|82701679|ref|YP_411245.1| integrase catalytic subunit 1260251001364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1260251001365 Transposase; Region: HTH_Tnp_1; pfam01527 1260251001366 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1260251001367 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1260251001368 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1260251001369 ATP binding site [chemical binding]; other site 1260251001370 Mg2+ binding site [ion binding]; other site 1260251001371 G-X-G motif; other site 1260251001372 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1260251001373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1260251001374 active site 1260251001375 phosphorylation site [posttranslational modification] 1260251001376 intermolecular recognition site; other site 1260251001377 dimerization interface [polypeptide binding]; other site 1260251001378 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1260251001379 DNA binding residues [nucleotide binding] 1260251001380 dimerization interface [polypeptide binding]; other site 1260251001381 putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486 1260251001382 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1260251001383 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1260251001384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1260251001385 dimer interface [polypeptide binding]; other site 1260251001386 conserved gate region; other site 1260251001387 putative PBP binding loops; other site 1260251001388 ABC-ATPase subunit interface; other site 1260251001389 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1260251001390 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 1260251001391 Walker A/P-loop; other site 1260251001392 ATP binding site [chemical binding]; other site 1260251001393 Q-loop/lid; other site 1260251001394 ABC transporter signature motif; other site 1260251001395 Walker B; other site 1260251001396 D-loop; other site 1260251001397 H-loop/switch region; other site 1260251001398 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1260251001399 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1260251001400 substrate binding pocket [chemical binding]; other site 1260251001401 membrane-bound complex binding site; other site 1260251001402 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1260251001403 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1260251001404 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1260251001405 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1260251001406 ligand binding site [chemical binding]; other site 1260251001407 translocation protein TolB; Provisional; Region: tolB; PRK04922 1260251001408 TolB amino-terminal domain; Region: TolB_N; pfam04052 1260251001409 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1260251001410 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1260251001411 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1260251001412 TolA protein; Region: tolA_full; TIGR02794 1260251001413 TonB C terminal; Region: TonB_2; pfam13103 1260251001414 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1260251001415 TolR protein; Region: tolR; TIGR02801 1260251001416 TolQ protein; Region: tolQ; TIGR02796 1260251001417 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1260251001418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251001419 Walker A motif; other site 1260251001420 ATP binding site [chemical binding]; other site 1260251001421 Walker B motif; other site 1260251001422 arginine finger; other site 1260251001423 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1260251001424 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1260251001425 RuvA N terminal domain; Region: RuvA_N; pfam01330 1260251001426 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1260251001427 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1260251001428 active site 1260251001429 putative DNA-binding cleft [nucleotide binding]; other site 1260251001430 dimer interface [polypeptide binding]; other site 1260251001431 hypothetical protein; Validated; Region: PRK00110 1260251001432 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1260251001433 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1260251001434 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1260251001435 putative acyltransferase; Provisional; Region: PRK05790 1260251001436 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1260251001437 dimer interface [polypeptide binding]; other site 1260251001438 active site 1260251001439 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 1260251001440 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 1260251001441 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 1260251001442 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 1260251001443 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1260251001444 NAD(P) binding site [chemical binding]; other site 1260251001445 homotetramer interface [polypeptide binding]; other site 1260251001446 homodimer interface [polypeptide binding]; other site 1260251001447 active site 1260251001448 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1260251001449 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1260251001450 substrate binding site [chemical binding]; other site 1260251001451 dimer interface [polypeptide binding]; other site 1260251001452 ATP binding site [chemical binding]; other site 1260251001453 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1260251001454 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1260251001455 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 1260251001456 Peptidase family M48; Region: Peptidase_M48; pfam01435 1260251001457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1260251001458 binding surface 1260251001459 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1260251001460 TPR motif; other site 1260251001461 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1260251001462 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1260251001463 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1260251001464 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1260251001465 putative active site [active] 1260251001466 PhoH-like protein; Region: PhoH; cl17668 1260251001467 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1260251001468 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1260251001469 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1260251001470 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1260251001471 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1260251001472 dimer interface [polypeptide binding]; other site 1260251001473 active site 1260251001474 catalytic residue [active] 1260251001475 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1260251001476 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1260251001477 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1260251001478 dimerization interface [polypeptide binding]; other site 1260251001479 ATP binding site [chemical binding]; other site 1260251001480 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1260251001481 dimerization interface [polypeptide binding]; other site 1260251001482 ATP binding site [chemical binding]; other site 1260251001483 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1260251001484 putative active site [active] 1260251001485 catalytic triad [active] 1260251001486 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1260251001487 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1260251001488 Moco binding site; other site 1260251001489 metal coordination site [ion binding]; other site 1260251001490 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1260251001491 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1260251001492 putative active site [active] 1260251001493 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1260251001494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251001495 Walker A motif; other site 1260251001496 ATP binding site [chemical binding]; other site 1260251001497 Walker B motif; other site 1260251001498 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1260251001499 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1260251001500 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1260251001501 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1260251001502 ABC transporter; Region: ABC_tran_2; pfam12848 1260251001503 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1260251001504 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1260251001505 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 1260251001506 putative ligand binding site [chemical binding]; other site 1260251001507 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1260251001508 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1260251001509 TM-ABC transporter signature motif; other site 1260251001510 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1260251001511 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1260251001512 TM-ABC transporter signature motif; other site 1260251001513 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1260251001514 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1260251001515 Walker A/P-loop; other site 1260251001516 ATP binding site [chemical binding]; other site 1260251001517 Q-loop/lid; other site 1260251001518 ABC transporter signature motif; other site 1260251001519 Walker B; other site 1260251001520 D-loop; other site 1260251001521 H-loop/switch region; other site 1260251001522 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1260251001523 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1260251001524 Walker A/P-loop; other site 1260251001525 ATP binding site [chemical binding]; other site 1260251001526 Q-loop/lid; other site 1260251001527 ABC transporter signature motif; other site 1260251001528 Walker B; other site 1260251001529 D-loop; other site 1260251001530 H-loop/switch region; other site 1260251001531 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1260251001532 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1260251001533 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1260251001534 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1260251001535 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 1260251001536 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1260251001537 EamA-like transporter family; Region: EamA; pfam00892 1260251001538 superoxide dismutase; Provisional; Region: PRK10543 1260251001539 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1260251001540 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1260251001541 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 1260251001542 potential frameshift: common BLAST hit: gi|114321281|ref|YP_742964.1| B12-dependent methionine synthase 1260251001543 Peptidase family M48; Region: Peptidase_M48; pfam01435 1260251001544 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1260251001545 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1260251001546 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1260251001547 putative active site [active] 1260251001548 putative substrate binding site [chemical binding]; other site 1260251001549 putative cosubstrate binding site; other site 1260251001550 catalytic site [active] 1260251001551 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1260251001552 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1260251001553 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1260251001554 ABC transporter; Region: ABC_tran_2; pfam12848 1260251001555 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1260251001556 Helix-turn-helix domain; Region: HTH_17; pfam12728 1260251001557 PBP superfamily domain; Region: PBP_like; pfam12727 1260251001558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1260251001559 dimer interface [polypeptide binding]; other site 1260251001560 conserved gate region; other site 1260251001561 putative PBP binding loops; other site 1260251001562 ABC-ATPase subunit interface; other site 1260251001563 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 1260251001564 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1260251001565 Walker A/P-loop; other site 1260251001566 ATP binding site [chemical binding]; other site 1260251001567 Q-loop/lid; other site 1260251001568 ABC transporter signature motif; other site 1260251001569 Walker B; other site 1260251001570 D-loop; other site 1260251001571 H-loop/switch region; other site 1260251001572 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 1260251001573 PBP superfamily domain; Region: PBP_like_2; pfam12849 1260251001574 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1260251001575 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1260251001576 dimer interface [polypeptide binding]; other site 1260251001577 active site 1260251001578 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1260251001579 folate binding site [chemical binding]; other site 1260251001580 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1260251001581 ATP cone domain; Region: ATP-cone; pfam03477 1260251001582 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1260251001583 catalytic motif [active] 1260251001584 Zn binding site [ion binding]; other site 1260251001585 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1260251001586 RibD C-terminal domain; Region: RibD_C; cl17279 1260251001587 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1260251001588 Lumazine binding domain; Region: Lum_binding; pfam00677 1260251001589 Lumazine binding domain; Region: Lum_binding; pfam00677 1260251001590 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1260251001591 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1260251001592 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1260251001593 dimerization interface [polypeptide binding]; other site 1260251001594 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1260251001595 homopentamer interface [polypeptide binding]; other site 1260251001596 active site 1260251001597 transcription antitermination factor NusB; Region: nusB; TIGR01951 1260251001598 thiamine monophosphate kinase; Provisional; Region: PRK05731 1260251001599 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1260251001600 ATP binding site [chemical binding]; other site 1260251001601 dimerization interface [polypeptide binding]; other site 1260251001602 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1260251001603 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1260251001604 ligand binding site [chemical binding]; other site 1260251001605 flexible hinge region; other site 1260251001606 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1260251001607 putative switch regulator; other site 1260251001608 non-specific DNA interactions [nucleotide binding]; other site 1260251001609 DNA binding site [nucleotide binding] 1260251001610 sequence specific DNA binding site [nucleotide binding]; other site 1260251001611 putative cAMP binding site [chemical binding]; other site 1260251001612 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 1260251001613 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 1260251001614 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1260251001615 inhibitor-cofactor binding pocket; inhibition site 1260251001616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251001617 catalytic residue [active] 1260251001618 succinic semialdehyde dehydrogenase; Region: PLN02278 1260251001619 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1260251001620 tetramerization interface [polypeptide binding]; other site 1260251001621 NAD(P) binding site [chemical binding]; other site 1260251001622 catalytic residues [active] 1260251001623 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1260251001624 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 1260251001625 NAD binding site [chemical binding]; other site 1260251001626 ligand binding site [chemical binding]; other site 1260251001627 catalytic site [active] 1260251001628 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1260251001629 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1260251001630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251001631 homodimer interface [polypeptide binding]; other site 1260251001632 catalytic residue [active] 1260251001633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1260251001634 Coenzyme A binding pocket [chemical binding]; other site 1260251001635 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1260251001636 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1260251001637 putative active site [active] 1260251001638 catalytic triad [active] 1260251001639 putative dimer interface [polypeptide binding]; other site 1260251001640 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1260251001641 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1260251001642 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1260251001643 Surface antigen; Region: Bac_surface_Ag; pfam01103 1260251001644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1260251001645 Family of unknown function (DUF490); Region: DUF490; pfam04357 1260251001646 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1260251001647 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1260251001648 ATP binding site [chemical binding]; other site 1260251001649 Mg++ binding site [ion binding]; other site 1260251001650 motif III; other site 1260251001651 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1260251001652 nucleotide binding region [chemical binding]; other site 1260251001653 ATP-binding site [chemical binding]; other site 1260251001654 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1260251001655 putative GSH binding site [chemical binding]; other site 1260251001656 catalytic residues [active] 1260251001657 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1260251001658 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1260251001659 dimer interface [polypeptide binding]; other site 1260251001660 catalytic site [active] 1260251001661 putative active site [active] 1260251001662 putative substrate binding site [chemical binding]; other site 1260251001663 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1260251001664 active site 1260251001665 substrate binding pocket [chemical binding]; other site 1260251001666 dimer interface [polypeptide binding]; other site 1260251001667 argininosuccinate synthase; Provisional; Region: PRK13820 1260251001668 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1260251001669 ANP binding site [chemical binding]; other site 1260251001670 Substrate Binding Site II [chemical binding]; other site 1260251001671 Substrate Binding Site I [chemical binding]; other site 1260251001672 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1260251001673 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1260251001674 intersubunit interface [polypeptide binding]; other site 1260251001675 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1260251001676 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1260251001677 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1260251001678 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1260251001679 ABC-ATPase subunit interface; other site 1260251001680 dimer interface [polypeptide binding]; other site 1260251001681 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1260251001682 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1260251001683 ABC-ATPase subunit interface; other site 1260251001684 dimer interface [polypeptide binding]; other site 1260251001685 putative PBP binding regions; other site 1260251001686 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1260251001687 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1260251001688 minor groove reading motif; other site 1260251001689 helix-hairpin-helix signature motif; other site 1260251001690 substrate binding pocket [chemical binding]; other site 1260251001691 active site 1260251001692 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1260251001693 ferredoxin; Provisional; Region: PRK08764 1260251001694 Putative Fe-S cluster; Region: FeS; pfam04060 1260251001695 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1260251001696 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 1260251001697 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1260251001698 active site 1260251001699 HIGH motif; other site 1260251001700 KMSKS motif; other site 1260251001701 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1260251001702 tRNA binding surface [nucleotide binding]; other site 1260251001703 anticodon binding site; other site 1260251001704 shikimate kinase; Reviewed; Region: aroK; PRK00131 1260251001705 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1260251001706 ADP binding site [chemical binding]; other site 1260251001707 magnesium binding site [ion binding]; other site 1260251001708 putative shikimate binding site; other site 1260251001709 antiporter inner membrane protein; Provisional; Region: PRK11670 1260251001710 Domain of unknown function DUF59; Region: DUF59; pfam01883 1260251001711 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1260251001712 Walker A motif; other site 1260251001713 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1260251001714 trimer interface [polypeptide binding]; other site 1260251001715 active site 1260251001716 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1260251001717 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1260251001718 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1260251001719 active site 1260251001720 substrate binding site [chemical binding]; other site 1260251001721 cosubstrate binding site; other site 1260251001722 catalytic site [active] 1260251001723 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1260251001724 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1260251001725 dimerization interface [polypeptide binding]; other site 1260251001726 putative ATP binding site [chemical binding]; other site 1260251001727 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 1260251001728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251001729 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1260251001730 Walker A motif; other site 1260251001731 ATP binding site [chemical binding]; other site 1260251001732 Walker B motif; other site 1260251001733 arginine finger; other site 1260251001734 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 1260251001735 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1260251001736 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1260251001737 Acylphosphatase; Region: Acylphosphatase; pfam00708 1260251001738 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1260251001739 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1260251001740 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1260251001741 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1260251001742 putative NAD(P) binding site [chemical binding]; other site 1260251001743 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1260251001744 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1260251001745 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1260251001746 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1260251001747 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1260251001748 dimer interface [polypeptide binding]; other site 1260251001749 motif 1; other site 1260251001750 active site 1260251001751 motif 2; other site 1260251001752 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1260251001753 putative deacylase active site [active] 1260251001754 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1260251001755 active site 1260251001756 motif 3; other site 1260251001757 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1260251001758 anticodon binding site; other site 1260251001759 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1260251001760 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1260251001761 putative valine binding site [chemical binding]; other site 1260251001762 dimer interface [polypeptide binding]; other site 1260251001763 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1260251001764 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1260251001765 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1260251001766 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1260251001767 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1260251001768 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1260251001769 2-isopropylmalate synthase; Validated; Region: PRK00915 1260251001770 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1260251001771 active site 1260251001772 catalytic residues [active] 1260251001773 metal binding site [ion binding]; metal-binding site 1260251001774 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1260251001775 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1260251001776 Fe-S cluster binding site [ion binding]; other site 1260251001777 active site 1260251001778 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1260251001779 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1260251001780 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1260251001781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1260251001782 putative substrate translocation pore; other site 1260251001783 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 1260251001784 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1260251001785 Na binding site [ion binding]; other site 1260251001786 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1260251001787 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1260251001788 HIGH motif; other site 1260251001789 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1260251001790 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1260251001791 active site 1260251001792 KMSKS motif; other site 1260251001793 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1260251001794 tRNA binding surface [nucleotide binding]; other site 1260251001795 anticodon binding site; other site 1260251001796 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1260251001797 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 1260251001798 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1260251001799 Predicted permeases [General function prediction only]; Region: COG0795 1260251001800 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1260251001801 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1260251001802 RDD family; Region: RDD; pfam06271 1260251001803 poly(A) polymerase; Region: pcnB; TIGR01942 1260251001804 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1260251001805 active site 1260251001806 NTP binding site [chemical binding]; other site 1260251001807 metal binding triad [ion binding]; metal-binding site 1260251001808 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1260251001809 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1260251001810 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1260251001811 catalytic center binding site [active] 1260251001812 ATP binding site [chemical binding]; other site 1260251001813 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1260251001814 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1260251001815 Substrate-binding site [chemical binding]; other site 1260251001816 Substrate specificity [chemical binding]; other site 1260251001817 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1260251001818 active site 1260251001819 oligomerization interface [polypeptide binding]; other site 1260251001820 metal binding site [ion binding]; metal-binding site 1260251001821 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1260251001822 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1260251001823 active site 1260251001824 ATP-binding site [chemical binding]; other site 1260251001825 pantoate-binding site; other site 1260251001826 HXXH motif; other site 1260251001827 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1260251001828 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1260251001829 active site 1260251001830 dimer interface [polypeptide binding]; other site 1260251001831 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1260251001832 dimer interface [polypeptide binding]; other site 1260251001833 active site 1260251001834 epoxyqueuosine reductase; Region: TIGR00276 1260251001835 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1260251001836 4Fe-4S binding domain; Region: Fer4; pfam00037 1260251001837 putative carbohydrate kinase; Provisional; Region: PRK10565 1260251001838 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1260251001839 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1260251001840 putative substrate binding site [chemical binding]; other site 1260251001841 putative ATP binding site [chemical binding]; other site 1260251001842 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1260251001843 AMIN domain; Region: AMIN; pfam11741 1260251001844 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1260251001845 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1260251001846 active site 1260251001847 metal binding site [ion binding]; metal-binding site 1260251001848 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1260251001849 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 1260251001850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1260251001851 ATP binding site [chemical binding]; other site 1260251001852 Mg2+ binding site [ion binding]; other site 1260251001853 G-X-G motif; other site 1260251001854 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1260251001855 ATP binding site [chemical binding]; other site 1260251001856 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1260251001857 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1260251001858 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1260251001859 bacterial Hfq-like; Region: Hfq; cd01716 1260251001860 hexamer interface [polypeptide binding]; other site 1260251001861 Sm1 motif; other site 1260251001862 RNA binding site [nucleotide binding]; other site 1260251001863 Sm2 motif; other site 1260251001864 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1260251001865 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1260251001866 HflX GTPase family; Region: HflX; cd01878 1260251001867 G1 box; other site 1260251001868 GTP/Mg2+ binding site [chemical binding]; other site 1260251001869 Switch I region; other site 1260251001870 G2 box; other site 1260251001871 G3 box; other site 1260251001872 Switch II region; other site 1260251001873 G4 box; other site 1260251001874 G5 box; other site 1260251001875 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1260251001876 HflK protein; Region: hflK; TIGR01933 1260251001877 FtsH protease regulator HflC; Provisional; Region: PRK11029 1260251001878 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1260251001879 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 1260251001880 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 1260251001881 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1260251001882 dimer interface [polypeptide binding]; other site 1260251001883 motif 1; other site 1260251001884 active site 1260251001885 motif 2; other site 1260251001886 motif 3; other site 1260251001887 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1260251001888 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1260251001889 GDP-binding site [chemical binding]; other site 1260251001890 ACT binding site; other site 1260251001891 IMP binding site; other site 1260251001892 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1260251001893 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1260251001894 Peptidase family M23; Region: Peptidase_M23; pfam01551 1260251001895 potential protein location (hypothetical protein SPISAL_02765 [Ectothiorhodospiraceae bacterium M19-40]) that overlaps RNA (tRNA-L) 1260251001896 ribonuclease R; Region: RNase_R; TIGR02063 1260251001897 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1260251001898 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1260251001899 RNB domain; Region: RNB; pfam00773 1260251001900 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1260251001901 RNA binding site [nucleotide binding]; other site 1260251001902 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1260251001903 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1260251001904 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1260251001905 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1260251001906 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1260251001907 generic binding surface II; other site 1260251001908 generic binding surface I; other site 1260251001909 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1260251001910 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1260251001911 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1260251001912 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1260251001913 replicative DNA helicase; Region: DnaB; TIGR00665 1260251001914 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1260251001915 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1260251001916 Walker A motif; other site 1260251001917 ATP binding site [chemical binding]; other site 1260251001918 Walker B motif; other site 1260251001919 DNA binding loops [nucleotide binding] 1260251001920 alanine racemase; Reviewed; Region: alr; PRK00053 1260251001921 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1260251001922 active site 1260251001923 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1260251001924 substrate binding site [chemical binding]; other site 1260251001925 catalytic residues [active] 1260251001926 dimer interface [polypeptide binding]; other site 1260251001927 DNA repair protein RadA; Provisional; Region: PRK11823 1260251001928 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1260251001929 Walker A motif; other site 1260251001930 ATP binding site [chemical binding]; other site 1260251001931 Walker B motif; other site 1260251001932 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1260251001933 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1260251001934 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1260251001935 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1260251001936 homodimer interface [polypeptide binding]; other site 1260251001937 NADP binding site [chemical binding]; other site 1260251001938 substrate binding site [chemical binding]; other site 1260251001939 helicase 45; Provisional; Region: PTZ00424 1260251001940 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1260251001941 ATP binding site [chemical binding]; other site 1260251001942 Mg++ binding site [ion binding]; other site 1260251001943 motif III; other site 1260251001944 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1260251001945 nucleotide binding region [chemical binding]; other site 1260251001946 ATP-binding site [chemical binding]; other site 1260251001947 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1260251001948 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1260251001949 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1260251001950 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1260251001951 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1260251001952 motif II; other site 1260251001953 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1260251001954 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1260251001955 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1260251001956 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1260251001957 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1260251001958 dimer interface [polypeptide binding]; other site 1260251001959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251001960 catalytic residue [active] 1260251001961 trigger factor; Provisional; Region: tig; PRK01490 1260251001962 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1260251001963 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1260251001964 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1260251001965 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1260251001966 oligomer interface [polypeptide binding]; other site 1260251001967 active site residues [active] 1260251001968 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1260251001969 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1260251001970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251001971 Walker A motif; other site 1260251001972 ATP binding site [chemical binding]; other site 1260251001973 Walker B motif; other site 1260251001974 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1260251001975 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1260251001976 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1260251001977 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1260251001978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251001979 Walker A motif; other site 1260251001980 ATP binding site [chemical binding]; other site 1260251001981 Walker B motif; other site 1260251001982 arginine finger; other site 1260251001983 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1260251001984 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1260251001985 IHF dimer interface [polypeptide binding]; other site 1260251001986 IHF - DNA interface [nucleotide binding]; other site 1260251001987 SurA N-terminal domain; Region: SurA_N_3; cl07813 1260251001988 periplasmic folding chaperone; Provisional; Region: PRK10788 1260251001989 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1260251001990 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1260251001991 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1260251001992 NAD binding site [chemical binding]; other site 1260251001993 homotetramer interface [polypeptide binding]; other site 1260251001994 homodimer interface [polypeptide binding]; other site 1260251001995 substrate binding site [chemical binding]; other site 1260251001996 active site 1260251001997 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1260251001998 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1260251001999 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1260251002000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1260251002001 dimer interface [polypeptide binding]; other site 1260251002002 conserved gate region; other site 1260251002003 putative PBP binding loops; other site 1260251002004 ABC-ATPase subunit interface; other site 1260251002005 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1260251002006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1260251002007 dimer interface [polypeptide binding]; other site 1260251002008 conserved gate region; other site 1260251002009 ABC-ATPase subunit interface; other site 1260251002010 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1260251002011 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1260251002012 Walker A/P-loop; other site 1260251002013 ATP binding site [chemical binding]; other site 1260251002014 Q-loop/lid; other site 1260251002015 ABC transporter signature motif; other site 1260251002016 Walker B; other site 1260251002017 D-loop; other site 1260251002018 H-loop/switch region; other site 1260251002019 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1260251002020 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1260251002021 Walker A/P-loop; other site 1260251002022 ATP binding site [chemical binding]; other site 1260251002023 Q-loop/lid; other site 1260251002024 ABC transporter signature motif; other site 1260251002025 Walker B; other site 1260251002026 D-loop; other site 1260251002027 H-loop/switch region; other site 1260251002028 GTP-binding protein Der; Reviewed; Region: PRK00093 1260251002029 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1260251002030 G1 box; other site 1260251002031 GTP/Mg2+ binding site [chemical binding]; other site 1260251002032 Switch I region; other site 1260251002033 G2 box; other site 1260251002034 Switch II region; other site 1260251002035 G3 box; other site 1260251002036 G4 box; other site 1260251002037 G5 box; other site 1260251002038 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1260251002039 G1 box; other site 1260251002040 GTP/Mg2+ binding site [chemical binding]; other site 1260251002041 Switch I region; other site 1260251002042 G2 box; other site 1260251002043 G3 box; other site 1260251002044 Switch II region; other site 1260251002045 G4 box; other site 1260251002046 G5 box; other site 1260251002047 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 1260251002048 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1260251002049 Probable Catalytic site; other site 1260251002050 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 1260251002051 Predicted small secreted protein [Function unknown]; Region: COG5510 1260251002052 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1260251002053 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1260251002054 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1260251002055 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1260251002056 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1260251002057 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1260251002058 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1260251002059 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1260251002060 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1260251002061 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1260251002062 Protein export membrane protein; Region: SecD_SecF; pfam02355 1260251002063 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1260251002064 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1260251002065 active site 1260251002066 dimerization interface [polypeptide binding]; other site 1260251002067 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1260251002068 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1260251002069 serine O-acetyltransferase; Region: cysE; TIGR01172 1260251002070 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1260251002071 trimer interface [polypeptide binding]; other site 1260251002072 active site 1260251002073 substrate binding site [chemical binding]; other site 1260251002074 CoA binding site [chemical binding]; other site 1260251002075 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1260251002076 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1260251002077 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1260251002078 catalytic residue [active] 1260251002079 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 1260251002080 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1260251002081 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1260251002082 active site 1260251002083 multimer interface [polypeptide binding]; other site 1260251002084 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1260251002085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1260251002086 FeS/SAM binding site; other site 1260251002087 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1260251002088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1260251002089 binding surface 1260251002090 TPR motif; other site 1260251002091 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1260251002092 binding surface 1260251002093 TPR motif; other site 1260251002094 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1260251002095 Helix-turn-helix domain; Region: HTH_25; pfam13413 1260251002096 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1260251002097 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1260251002098 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1260251002099 dimer interface [polypeptide binding]; other site 1260251002100 motif 1; other site 1260251002101 active site 1260251002102 motif 2; other site 1260251002103 motif 3; other site 1260251002104 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1260251002105 anticodon binding site; other site 1260251002106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1260251002107 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1260251002108 Trp docking motif [polypeptide binding]; other site 1260251002109 active site 1260251002110 PQQ-like domain; Region: PQQ_2; pfam13360 1260251002111 PQQ-like domain; Region: PQQ_2; pfam13360 1260251002112 adenylate kinase; Reviewed; Region: adk; PRK00279 1260251002113 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1260251002114 AMP-binding site [chemical binding]; other site 1260251002115 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1260251002116 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1260251002117 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 1260251002118 dimer interface [polypeptide binding]; other site 1260251002119 active site residues [active] 1260251002120 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1260251002121 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1260251002122 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1260251002123 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1260251002124 H-NS histone family; Region: Histone_HNS; pfam00816 1260251002125 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1260251002126 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1260251002127 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1260251002128 active site 1260251002129 inner membrane transport permease; Provisional; Region: PRK15066 1260251002130 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1260251002131 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1260251002132 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1260251002133 Walker A/P-loop; other site 1260251002134 ATP binding site [chemical binding]; other site 1260251002135 Q-loop/lid; other site 1260251002136 ABC transporter signature motif; other site 1260251002137 Walker B; other site 1260251002138 D-loop; other site 1260251002139 H-loop/switch region; other site 1260251002140 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1260251002141 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1260251002142 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1260251002143 catalytic site [active] 1260251002144 subunit interface [polypeptide binding]; other site 1260251002145 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1260251002146 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1260251002147 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1260251002148 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1260251002149 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1260251002150 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1260251002151 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1260251002152 IMP binding site; other site 1260251002153 dimer interface [polypeptide binding]; other site 1260251002154 interdomain contacts; other site 1260251002155 partial ornithine binding site; other site 1260251002156 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1260251002157 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1260251002158 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1260251002159 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1260251002160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1260251002161 S-adenosylmethionine binding site [chemical binding]; other site 1260251002162 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1260251002163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251002164 Walker A motif; other site 1260251002165 ATP binding site [chemical binding]; other site 1260251002166 Walker B motif; other site 1260251002167 arginine finger; other site 1260251002168 Peptidase family M41; Region: Peptidase_M41; pfam01434 1260251002169 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1260251002170 dihydropteroate synthase; Region: DHPS; TIGR01496 1260251002171 substrate binding pocket [chemical binding]; other site 1260251002172 dimer interface [polypeptide binding]; other site 1260251002173 inhibitor binding site; inhibition site 1260251002174 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1260251002175 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1260251002176 active site 1260251002177 substrate binding site [chemical binding]; other site 1260251002178 metal binding site [ion binding]; metal-binding site 1260251002179 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1260251002180 triosephosphate isomerase; Provisional; Region: PRK14567 1260251002181 substrate binding site [chemical binding]; other site 1260251002182 dimer interface [polypeptide binding]; other site 1260251002183 catalytic triad [active] 1260251002184 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1260251002185 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1260251002186 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1260251002187 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 1260251002188 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1260251002189 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1260251002190 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1260251002191 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1260251002192 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1260251002193 putative dimer interface [polypeptide binding]; other site 1260251002194 [2Fe-2S] cluster binding site [ion binding]; other site 1260251002195 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1260251002196 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1260251002197 SLBB domain; Region: SLBB; pfam10531 1260251002198 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1260251002199 NADH dehydrogenase subunit G; Validated; Region: PRK09129 1260251002200 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1260251002201 catalytic loop [active] 1260251002202 iron binding site [ion binding]; other site 1260251002203 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1260251002204 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1260251002205 molybdopterin cofactor binding site; other site 1260251002206 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1260251002207 molybdopterin cofactor binding site; other site 1260251002208 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1260251002209 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1260251002210 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1260251002211 4Fe-4S binding domain; Region: Fer4; pfam00037 1260251002212 4Fe-4S binding domain; Region: Fer4; cl02805 1260251002213 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1260251002214 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1260251002215 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1260251002216 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1260251002217 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1260251002218 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1260251002219 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1260251002220 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1260251002221 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1260251002222 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 1260251002223 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1260251002224 Sm and related proteins; Region: Sm_like; cl00259 1260251002225 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1260251002226 putative oligomer interface [polypeptide binding]; other site 1260251002227 putative RNA binding site [nucleotide binding]; other site 1260251002228 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1260251002229 NusA N-terminal domain; Region: NusA_N; pfam08529 1260251002230 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1260251002231 RNA binding site [nucleotide binding]; other site 1260251002232 homodimer interface [polypeptide binding]; other site 1260251002233 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1260251002234 G-X-X-G motif; other site 1260251002235 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1260251002236 G-X-X-G motif; other site 1260251002237 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1260251002238 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1260251002239 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1260251002240 translation initiation factor IF-2; Region: IF-2; TIGR00487 1260251002241 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1260251002242 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1260251002243 G1 box; other site 1260251002244 putative GEF interaction site [polypeptide binding]; other site 1260251002245 GTP/Mg2+ binding site [chemical binding]; other site 1260251002246 Switch I region; other site 1260251002247 G2 box; other site 1260251002248 G3 box; other site 1260251002249 Switch II region; other site 1260251002250 G4 box; other site 1260251002251 G5 box; other site 1260251002252 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1260251002253 Translation-initiation factor 2; Region: IF-2; pfam11987 1260251002254 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1260251002255 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1260251002256 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1260251002257 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1260251002258 RNA binding site [nucleotide binding]; other site 1260251002259 active site 1260251002260 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1260251002261 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1260251002262 16S/18S rRNA binding site [nucleotide binding]; other site 1260251002263 S13e-L30e interaction site [polypeptide binding]; other site 1260251002264 25S rRNA binding site [nucleotide binding]; other site 1260251002265 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1260251002266 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1260251002267 RNase E interface [polypeptide binding]; other site 1260251002268 trimer interface [polypeptide binding]; other site 1260251002269 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1260251002270 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1260251002271 RNase E interface [polypeptide binding]; other site 1260251002272 trimer interface [polypeptide binding]; other site 1260251002273 active site 1260251002274 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1260251002275 putative nucleic acid binding region [nucleotide binding]; other site 1260251002276 G-X-X-G motif; other site 1260251002277 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1260251002278 RNA binding site [nucleotide binding]; other site 1260251002279 domain interface; other site 1260251002280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1260251002281 PAS domain; Region: PAS_9; pfam13426 1260251002282 putative active site [active] 1260251002283 heme pocket [chemical binding]; other site 1260251002284 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1260251002285 active site 1260251002286 catalytic site [active] 1260251002287 substrate binding site [chemical binding]; other site 1260251002288 Response regulator receiver domain; Region: Response_reg; pfam00072 1260251002289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1260251002290 active site 1260251002291 phosphorylation site [posttranslational modification] 1260251002292 intermolecular recognition site; other site 1260251002293 dimerization interface [polypeptide binding]; other site 1260251002294 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1260251002295 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1260251002296 ligand binding site [chemical binding]; other site 1260251002297 flexible hinge region; other site 1260251002298 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1260251002299 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1260251002300 metal binding triad; other site 1260251002301 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1260251002302 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1260251002303 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1260251002304 Na binding site [ion binding]; other site 1260251002305 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 1260251002306 acetyl-CoA synthetase; Provisional; Region: PRK00174 1260251002307 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1260251002308 active site 1260251002309 CoA binding site [chemical binding]; other site 1260251002310 acyl-activating enzyme (AAE) consensus motif; other site 1260251002311 AMP binding site [chemical binding]; other site 1260251002312 acetate binding site [chemical binding]; other site 1260251002313 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1260251002314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1260251002315 active site 1260251002316 phosphorylation site [posttranslational modification] 1260251002317 intermolecular recognition site; other site 1260251002318 dimerization interface [polypeptide binding]; other site 1260251002319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251002320 Walker A motif; other site 1260251002321 ATP binding site [chemical binding]; other site 1260251002322 Walker B motif; other site 1260251002323 arginine finger; other site 1260251002324 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1260251002325 Na binding site [ion binding]; other site 1260251002326 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1260251002327 PAS domain; Region: PAS; smart00091 1260251002328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1260251002329 dimer interface [polypeptide binding]; other site 1260251002330 phosphorylation site [posttranslational modification] 1260251002331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1260251002332 ATP binding site [chemical binding]; other site 1260251002333 Mg2+ binding site [ion binding]; other site 1260251002334 G-X-G motif; other site 1260251002335 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 1260251002336 active site 1260251002337 HIGH motif; other site 1260251002338 nucleotide binding site [chemical binding]; other site 1260251002339 KMSKS motif; other site 1260251002340 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1260251002341 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1260251002342 Walker A/P-loop; other site 1260251002343 ATP binding site [chemical binding]; other site 1260251002344 Q-loop/lid; other site 1260251002345 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 1260251002346 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1260251002347 ABC transporter signature motif; other site 1260251002348 Walker B; other site 1260251002349 D-loop; other site 1260251002350 H-loop/switch region; other site 1260251002351 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 1260251002352 FtsZ protein binding site [polypeptide binding]; other site 1260251002353 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1260251002354 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1260251002355 nucleotide binding pocket [chemical binding]; other site 1260251002356 K-X-D-G motif; other site 1260251002357 catalytic site [active] 1260251002358 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1260251002359 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1260251002360 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1260251002361 Dimer interface [polypeptide binding]; other site 1260251002362 BRCT sequence motif; other site 1260251002363 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1260251002364 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1260251002365 BolA-like protein; Region: BolA; pfam01722 1260251002366 YciI-like protein; Reviewed; Region: PRK11370 1260251002367 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1260251002368 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1260251002369 active site 1260251002370 HIGH motif; other site 1260251002371 dimer interface [polypeptide binding]; other site 1260251002372 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1260251002373 active site 1260251002374 KMSKS motif; other site 1260251002375 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1260251002376 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1260251002377 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1260251002378 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1260251002379 RNA binding surface [nucleotide binding]; other site 1260251002380 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1260251002381 active site 1260251002382 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 1260251002383 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1260251002384 minor groove reading motif; other site 1260251002385 helix-hairpin-helix signature motif; other site 1260251002386 substrate binding pocket [chemical binding]; other site 1260251002387 active site 1260251002388 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1260251002389 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1260251002390 substrate binding site [chemical binding]; other site 1260251002391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1260251002392 NAD(P) binding site [chemical binding]; other site 1260251002393 active site 1260251002394 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1260251002395 substrate binding pocket [chemical binding]; other site 1260251002396 substrate-Mg2+ binding site; other site 1260251002397 aspartate-rich region 1; other site 1260251002398 aspartate-rich region 2; other site 1260251002399 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1260251002400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1260251002401 motif II; other site 1260251002402 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1260251002403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1260251002404 S-adenosylmethionine binding site [chemical binding]; other site 1260251002405 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1260251002406 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1260251002407 active site 1260251002408 putative substrate binding pocket [chemical binding]; other site 1260251002409 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1260251002410 active site 1260251002411 DNA gyrase subunit A; Validated; Region: PRK05560 1260251002412 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1260251002413 CAP-like domain; other site 1260251002414 active site 1260251002415 primary dimer interface [polypeptide binding]; other site 1260251002416 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1260251002417 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1260251002418 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1260251002419 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1260251002420 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1260251002421 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1260251002422 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1260251002423 homodimer interface [polypeptide binding]; other site 1260251002424 substrate-cofactor binding pocket; other site 1260251002425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251002426 catalytic residue [active] 1260251002427 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1260251002428 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1260251002429 putative ligand binding site [chemical binding]; other site 1260251002430 putative NAD binding site [chemical binding]; other site 1260251002431 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1260251002432 L-serine binding site [chemical binding]; other site 1260251002433 ACT domain interface; other site 1260251002434 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 1260251002435 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1260251002436 Prephenate dehydratase; Region: PDT; pfam00800 1260251002437 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1260251002438 putative L-Phe binding site [chemical binding]; other site 1260251002439 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 1260251002440 prephenate dehydrogenase; Validated; Region: PRK08507 1260251002441 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1260251002442 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1260251002443 hinge; other site 1260251002444 active site 1260251002445 cytidylate kinase; Provisional; Region: cmk; PRK00023 1260251002446 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1260251002447 CMP-binding site; other site 1260251002448 The sites determining sugar specificity; other site 1260251002449 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1260251002450 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1260251002451 RNA binding site [nucleotide binding]; other site 1260251002452 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1260251002453 RNA binding site [nucleotide binding]; other site 1260251002454 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1260251002455 RNA binding site [nucleotide binding]; other site 1260251002456 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1260251002457 RNA binding site [nucleotide binding]; other site 1260251002458 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1260251002459 RNA binding site [nucleotide binding]; other site 1260251002460 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1260251002461 RNA binding site [nucleotide binding]; other site 1260251002462 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1260251002463 IHF - DNA interface [nucleotide binding]; other site 1260251002464 IHF dimer interface [polypeptide binding]; other site 1260251002465 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 1260251002466 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1260251002467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1260251002468 binding surface 1260251002469 TPR motif; other site 1260251002470 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1260251002471 active site 1260251002472 dimer interface [polypeptide binding]; other site 1260251002473 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1260251002474 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1260251002475 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1260251002476 active site 1260251002477 tetramer interface; other site 1260251002478 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1260251002479 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1260251002480 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1260251002481 dimerization interface [polypeptide binding]; other site 1260251002482 putative DNA binding site [nucleotide binding]; other site 1260251002483 putative Zn2+ binding site [ion binding]; other site 1260251002484 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1260251002485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1260251002486 Walker A/P-loop; other site 1260251002487 ATP binding site [chemical binding]; other site 1260251002488 Q-loop/lid; other site 1260251002489 ABC transporter signature motif; other site 1260251002490 Walker B; other site 1260251002491 D-loop; other site 1260251002492 H-loop/switch region; other site 1260251002493 TOBE domain; Region: TOBE_2; pfam08402 1260251002494 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1260251002495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1260251002496 putative PBP binding loops; other site 1260251002497 ABC-ATPase subunit interface; other site 1260251002498 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1260251002499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1260251002500 dimer interface [polypeptide binding]; other site 1260251002501 conserved gate region; other site 1260251002502 putative PBP binding loops; other site 1260251002503 ABC-ATPase subunit interface; other site 1260251002504 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1260251002505 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1260251002506 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1260251002507 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1260251002508 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1260251002509 aspartate aminotransferase; Provisional; Region: PRK05764 1260251002510 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1260251002511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251002512 homodimer interface [polypeptide binding]; other site 1260251002513 catalytic residue [active] 1260251002514 excinuclease ABC subunit B; Provisional; Region: PRK05298 1260251002515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1260251002516 ATP binding site [chemical binding]; other site 1260251002517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1260251002518 nucleotide binding region [chemical binding]; other site 1260251002519 ATP-binding site [chemical binding]; other site 1260251002520 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1260251002521 UvrB/uvrC motif; Region: UVR; pfam02151 1260251002522 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1260251002523 malonic semialdehyde reductase; Provisional; Region: PRK10538 1260251002524 putative NAD(P) binding site [chemical binding]; other site 1260251002525 homotetramer interface [polypeptide binding]; other site 1260251002526 homodimer interface [polypeptide binding]; other site 1260251002527 active site 1260251002528 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1260251002529 Domain of unknown function (DUF897); Region: DUF897; cl01312 1260251002530 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1260251002531 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1260251002532 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1260251002533 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1260251002534 phosphate binding site [ion binding]; other site 1260251002535 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1260251002536 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1260251002537 active site 1260251002538 nucleophile elbow; other site 1260251002539 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1260251002540 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1260251002541 catalytic residues [active] 1260251002542 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1260251002543 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1260251002544 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1260251002545 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1260251002546 active site 1260251002547 dimer interface [polypeptide binding]; other site 1260251002548 motif 1; other site 1260251002549 motif 2; other site 1260251002550 motif 3; other site 1260251002551 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1260251002552 anticodon binding site; other site 1260251002553 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1260251002554 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1260251002555 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1260251002556 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1260251002557 23S rRNA binding site [nucleotide binding]; other site 1260251002558 L21 binding site [polypeptide binding]; other site 1260251002559 L13 binding site [polypeptide binding]; other site 1260251002560 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1260251002561 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1260251002562 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1260251002563 dimer interface [polypeptide binding]; other site 1260251002564 motif 1; other site 1260251002565 active site 1260251002566 motif 2; other site 1260251002567 motif 3; other site 1260251002568 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1260251002569 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1260251002570 putative tRNA-binding site [nucleotide binding]; other site 1260251002571 B3/4 domain; Region: B3_4; pfam03483 1260251002572 tRNA synthetase B5 domain; Region: B5; smart00874 1260251002573 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1260251002574 dimer interface [polypeptide binding]; other site 1260251002575 motif 1; other site 1260251002576 motif 3; other site 1260251002577 motif 2; other site 1260251002578 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1260251002579 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1260251002580 IHF dimer interface [polypeptide binding]; other site 1260251002581 IHF - DNA interface [nucleotide binding]; other site 1260251002582 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1260251002583 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1260251002584 DNA binding residues [nucleotide binding] 1260251002585 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1260251002586 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1260251002587 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 1260251002588 putative active site [active] 1260251002589 Zn binding site [ion binding]; other site 1260251002590 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1260251002591 Predicted permeases [General function prediction only]; Region: COG0679 1260251002592 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1260251002593 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1260251002594 catalytic triad [active] 1260251002595 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1260251002596 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1260251002597 putative active site [active] 1260251002598 glucokinase; Provisional; Region: glk; PRK00292 1260251002599 glucokinase, proteobacterial type; Region: glk; TIGR00749 1260251002600 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1260251002601 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1260251002602 putative active site [active] 1260251002603 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1260251002604 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1260251002605 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1260251002606 phosphogluconate dehydratase; Validated; Region: PRK09054 1260251002607 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1260251002608 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1260251002609 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1260251002610 active site 1260251002611 intersubunit interface [polypeptide binding]; other site 1260251002612 catalytic residue [active] 1260251002613 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 1260251002614 Transcriptional regulator; Region: Rrf2; pfam02082 1260251002615 Transcriptional regulator; Region: Rrf2; cl17282 1260251002616 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1260251002617 putative ABC transporter; Region: ycf24; CHL00085 1260251002618 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1260251002619 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1260251002620 Walker A/P-loop; other site 1260251002621 ATP binding site [chemical binding]; other site 1260251002622 Q-loop/lid; other site 1260251002623 ABC transporter signature motif; other site 1260251002624 Walker B; other site 1260251002625 D-loop; other site 1260251002626 H-loop/switch region; other site 1260251002627 FeS assembly protein SufD; Region: sufD; TIGR01981 1260251002628 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1260251002629 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1260251002630 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1260251002631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1260251002632 catalytic residue [active] 1260251002633 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1260251002634 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1260251002635 trimerization site [polypeptide binding]; other site 1260251002636 active site 1260251002637 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 1260251002638 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1260251002639 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1260251002640 phosphopeptide binding site; other site 1260251002641 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1260251002642 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1260251002643 ATP binding site [chemical binding]; other site 1260251002644 Walker A motif; other site 1260251002645 hexamer interface [polypeptide binding]; other site 1260251002646 Walker B motif; other site 1260251002647 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1260251002648 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1260251002649 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1260251002650 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1260251002651 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1260251002652 active site 1260251002653 catalytic triad [active] 1260251002654 dimer interface [polypeptide binding]; other site 1260251002655 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1260251002656 binding surface 1260251002657 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1260251002658 TPR motif; other site 1260251002659 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1260251002660 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1260251002661 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1260251002662 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1260251002663 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1260251002664 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1260251002665 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 1260251002666 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1260251002667 NAD(P) binding site [chemical binding]; other site 1260251002668 homotetramer interface [polypeptide binding]; other site 1260251002669 homodimer interface [polypeptide binding]; other site 1260251002670 active site 1260251002671 Transcriptional activator HlyU; Region: HlyU; pfam10115 1260251002672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1260251002673 S-adenosylmethionine binding site [chemical binding]; other site 1260251002674 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1260251002675 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 1260251002676 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1260251002677 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1260251002678 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1260251002679 VIT family; Region: VIT1; pfam01988 1260251002680 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1260251002681 Ligand Binding Site [chemical binding]; other site 1260251002682 Competence-damaged protein; Region: CinA; cl00666 1260251002683 recombinase A; Provisional; Region: recA; PRK09354 1260251002684 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1260251002685 hexamer interface [polypeptide binding]; other site 1260251002686 Walker A motif; other site 1260251002687 ATP binding site [chemical binding]; other site 1260251002688 Walker B motif; other site 1260251002689 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1260251002690 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1260251002691 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1260251002692 motif 1; other site 1260251002693 active site 1260251002694 motif 2; other site 1260251002695 motif 3; other site 1260251002696 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1260251002697 DHHA1 domain; Region: DHHA1; pfam02272 1260251002698 aspartate kinase; Reviewed; Region: PRK06635 1260251002699 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1260251002700 putative nucleotide binding site [chemical binding]; other site 1260251002701 putative catalytic residues [active] 1260251002702 putative Mg ion binding site [ion binding]; other site 1260251002703 putative aspartate binding site [chemical binding]; other site 1260251002704 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1260251002705 putative allosteric regulatory site; other site 1260251002706 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1260251002707 carbon storage regulator; Provisional; Region: PRK01712 1260251002708 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1260251002709 active site 1260251002710 intersubunit interactions; other site 1260251002711 catalytic residue [active] 1260251002712 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1260251002713 Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; cl01891 1260251002714 isocitrate dehydrogenase; Validated; Region: PRK07362 1260251002715 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1260251002716 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1260251002717 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1260251002718 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1260251002719 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1260251002720 DNA binding site [nucleotide binding] 1260251002721 active site 1260251002722 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1260251002723 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1260251002724 metal binding site [ion binding]; metal-binding site 1260251002725 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1260251002726 LabA_like proteins; Region: LabA_like; cd06167 1260251002727 putative metal binding site [ion binding]; other site 1260251002728 Predicted membrane protein [Function unknown]; Region: COG3174 1260251002729 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1260251002730 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1260251002731 Protein of unknown function (DUF3581); Region: DUF3581; pfam12119 1260251002732 Pathogenicity locus; Region: Cdd1; pfam11731 1260251002733 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1260251002734 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1260251002735 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1260251002736 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1260251002737 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1260251002738 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1260251002739 Membrane transport protein; Region: Mem_trans; cl09117 1260251002740 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1260251002741 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1260251002742 HlyD family secretion protein; Region: HlyD_3; pfam13437 1260251002743 Phasin protein; Region: Phasin_2; cl11491 1260251002744 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1260251002745 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1260251002746 Predicted acyl esterases [General function prediction only]; Region: COG2936 1260251002747 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1260251002748 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1260251002749 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1260251002750 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1260251002751 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1260251002752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1260251002753 dimer interface [polypeptide binding]; other site 1260251002754 conserved gate region; other site 1260251002755 putative PBP binding loops; other site 1260251002756 ABC-ATPase subunit interface; other site 1260251002757 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1260251002758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1260251002759 dimer interface [polypeptide binding]; other site 1260251002760 conserved gate region; other site 1260251002761 putative PBP binding loops; other site 1260251002762 ABC-ATPase subunit interface; other site 1260251002763 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1260251002764 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1260251002765 Walker A/P-loop; other site 1260251002766 ATP binding site [chemical binding]; other site 1260251002767 Q-loop/lid; other site 1260251002768 ABC transporter signature motif; other site 1260251002769 Walker B; other site 1260251002770 D-loop; other site 1260251002771 H-loop/switch region; other site 1260251002772 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1260251002773 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1260251002774 Walker A/P-loop; other site 1260251002775 ATP binding site [chemical binding]; other site 1260251002776 Q-loop/lid; other site 1260251002777 ABC transporter signature motif; other site 1260251002778 Walker B; other site 1260251002779 D-loop; other site 1260251002780 H-loop/switch region; other site 1260251002781 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1260251002782 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1260251002783 homodimer interaction site [polypeptide binding]; other site 1260251002784 cofactor binding site; other site 1260251002785 cysteine synthase B; Region: cysM; TIGR01138 1260251002786 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1260251002787 dimer interface [polypeptide binding]; other site 1260251002788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251002789 catalytic residue [active] 1260251002790 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 1260251002791 active site 1260251002792 catalytic site [active] 1260251002793 substrate binding site [chemical binding]; other site 1260251002794 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 1260251002795 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1260251002796 TRAM domain; Region: TRAM; pfam01938 1260251002797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1260251002798 S-adenosylmethionine binding site [chemical binding]; other site 1260251002799 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1260251002800 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1260251002801 dimer interface [polypeptide binding]; other site 1260251002802 ADP-ribose binding site [chemical binding]; other site 1260251002803 active site 1260251002804 nudix motif; other site 1260251002805 metal binding site [ion binding]; metal-binding site 1260251002806 adenylosuccinate lyase; Provisional; Region: PRK09285 1260251002807 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1260251002808 tetramer interface [polypeptide binding]; other site 1260251002809 active site 1260251002810 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1260251002811 Class II fumarases; Region: Fumarase_classII; cd01362 1260251002812 active site 1260251002813 tetramer interface [polypeptide binding]; other site 1260251002814 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1260251002815 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1260251002816 GIY-YIG motif/motif A; other site 1260251002817 active site 1260251002818 catalytic site [active] 1260251002819 putative DNA binding site [nucleotide binding]; other site 1260251002820 metal binding site [ion binding]; metal-binding site 1260251002821 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1260251002822 Helix-hairpin-helix motif; Region: HHH; pfam00633 1260251002823 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1260251002824 dihydromonapterin reductase; Provisional; Region: PRK06483 1260251002825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1260251002826 NAD(P) binding site [chemical binding]; other site 1260251002827 active site 1260251002828 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1260251002829 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1260251002830 dimer interface [polypeptide binding]; other site 1260251002831 active site 1260251002832 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1260251002833 active site 1 [active] 1260251002834 dimer interface [polypeptide binding]; other site 1260251002835 active site 2 [active] 1260251002836 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1260251002837 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1260251002838 TPP-binding site; other site 1260251002839 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1260251002840 PYR/PP interface [polypeptide binding]; other site 1260251002841 dimer interface [polypeptide binding]; other site 1260251002842 TPP binding site [chemical binding]; other site 1260251002843 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1260251002844 hypothetical protein; Provisional; Region: PRK05170 1260251002845 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1260251002846 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1260251002847 G1 box; other site 1260251002848 putative GEF interaction site [polypeptide binding]; other site 1260251002849 GTP/Mg2+ binding site [chemical binding]; other site 1260251002850 Switch I region; other site 1260251002851 G2 box; other site 1260251002852 G3 box; other site 1260251002853 Switch II region; other site 1260251002854 G4 box; other site 1260251002855 G5 box; other site 1260251002856 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1260251002857 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 1260251002858 active site 1260251002859 intersubunit interface [polypeptide binding]; other site 1260251002860 catalytic residue [active] 1260251002861 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1260251002862 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1260251002863 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 1260251002864 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1260251002865 glycerate dehydrogenase; Provisional; Region: PRK06487 1260251002866 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1260251002867 putative ligand binding site [chemical binding]; other site 1260251002868 putative NAD binding site [chemical binding]; other site 1260251002869 catalytic site [active] 1260251002870 short chain dehydrogenase; Provisional; Region: PRK08219 1260251002871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1260251002872 NAD(P) binding site [chemical binding]; other site 1260251002873 active site 1260251002874 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 1260251002875 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1260251002876 active site 1260251002877 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 1260251002878 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1260251002879 thymidylate kinase; Validated; Region: tmk; PRK00698 1260251002880 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1260251002881 TMP-binding site; other site 1260251002882 ATP-binding site [chemical binding]; other site 1260251002883 YceG-like family; Region: YceG; pfam02618 1260251002884 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1260251002885 dimerization interface [polypeptide binding]; other site 1260251002886 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1260251002887 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1260251002888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251002889 catalytic residue [active] 1260251002890 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1260251002891 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1260251002892 dimer interface [polypeptide binding]; other site 1260251002893 active site 1260251002894 acyl carrier protein; Provisional; Region: acpP; PRK00982 1260251002895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1260251002896 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1260251002897 NAD(P) binding site [chemical binding]; other site 1260251002898 active site 1260251002899 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1260251002900 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1260251002901 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1260251002902 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1260251002903 dimer interface [polypeptide binding]; other site 1260251002904 active site 1260251002905 CoA binding pocket [chemical binding]; other site 1260251002906 putative phosphate acyltransferase; Provisional; Region: PRK05331 1260251002907 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1260251002908 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1260251002909 Maf-like protein; Region: Maf; pfam02545 1260251002910 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1260251002911 active site 1260251002912 dimer interface [polypeptide binding]; other site 1260251002913 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1260251002914 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1260251002915 tandem repeat interface [polypeptide binding]; other site 1260251002916 oligomer interface [polypeptide binding]; other site 1260251002917 active site residues [active] 1260251002918 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1260251002919 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1260251002920 RNA binding surface [nucleotide binding]; other site 1260251002921 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1260251002922 active site 1260251002923 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1260251002924 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1260251002925 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1260251002926 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1260251002927 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1260251002928 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1260251002929 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1260251002930 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1260251002931 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 1260251002932 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1260251002933 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1260251002934 Ligand binding site [chemical binding]; other site 1260251002935 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1260251002936 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1260251002937 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1260251002938 homodimer interface [polypeptide binding]; other site 1260251002939 oligonucleotide binding site [chemical binding]; other site 1260251002940 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1260251002941 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1260251002942 active site 1260251002943 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1260251002944 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1260251002945 Ligand binding site; other site 1260251002946 oligomer interface; other site 1260251002947 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1260251002948 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1260251002949 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1260251002950 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1260251002951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1260251002952 Walker A/P-loop; other site 1260251002953 ATP binding site [chemical binding]; other site 1260251002954 Q-loop/lid; other site 1260251002955 ABC transporter signature motif; other site 1260251002956 Walker B; other site 1260251002957 D-loop; other site 1260251002958 H-loop/switch region; other site 1260251002959 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1260251002960 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1260251002961 Competence protein; Region: Competence; pfam03772 1260251002962 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1260251002963 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1260251002964 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1260251002965 Walker A/P-loop; other site 1260251002966 ATP binding site [chemical binding]; other site 1260251002967 Q-loop/lid; other site 1260251002968 ABC transporter signature motif; other site 1260251002969 Walker B; other site 1260251002970 D-loop; other site 1260251002971 H-loop/switch region; other site 1260251002972 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1260251002973 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1260251002974 FtsX-like permease family; Region: FtsX; pfam02687 1260251002975 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1260251002976 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1260251002977 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1260251002978 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1260251002979 ATP binding site [chemical binding]; other site 1260251002980 putative Mg++ binding site [ion binding]; other site 1260251002981 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1260251002982 nucleotide binding region [chemical binding]; other site 1260251002983 ATP-binding site [chemical binding]; other site 1260251002984 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1260251002985 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 1260251002986 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1260251002987 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1260251002988 active site 1260251002989 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1260251002990 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1260251002991 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1260251002992 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1260251002993 catalytic core [active] 1260251002994 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1260251002995 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1260251002996 trimer interface [polypeptide binding]; other site 1260251002997 dimer interface [polypeptide binding]; other site 1260251002998 putative active site [active] 1260251002999 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 1260251003000 aromatic arch; other site 1260251003001 DCoH dimer interaction site [polypeptide binding]; other site 1260251003002 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1260251003003 DCoH tetramer interaction site [polypeptide binding]; other site 1260251003004 substrate binding site [chemical binding]; other site 1260251003005 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1260251003006 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1260251003007 homodimer interface [polypeptide binding]; other site 1260251003008 metal binding site [ion binding]; metal-binding site 1260251003009 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1260251003010 homodimer interface [polypeptide binding]; other site 1260251003011 active site 1260251003012 putative chemical substrate binding site [chemical binding]; other site 1260251003013 metal binding site [ion binding]; metal-binding site 1260251003014 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1260251003015 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1260251003016 C-terminal domain interface [polypeptide binding]; other site 1260251003017 GSH binding site (G-site) [chemical binding]; other site 1260251003018 dimer interface [polypeptide binding]; other site 1260251003019 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1260251003020 N-terminal domain interface [polypeptide binding]; other site 1260251003021 putative dimer interface [polypeptide binding]; other site 1260251003022 active site 1260251003023 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1260251003024 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1260251003025 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1260251003026 Ferredoxin [Energy production and conversion]; Region: COG1146 1260251003027 4Fe-4S binding domain; Region: Fer4; cl02805 1260251003028 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1260251003029 Transcriptional regulator; Region: Rrf2; cl17282 1260251003030 Rrf2 family protein; Region: rrf2_super; TIGR00738 1260251003031 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1260251003032 dimer interface [polypeptide binding]; other site 1260251003033 substrate binding site [chemical binding]; other site 1260251003034 ATP binding site [chemical binding]; other site 1260251003035 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1260251003036 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1260251003037 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1260251003038 acyl-activating enzyme (AAE) consensus motif; other site 1260251003039 acyl-activating enzyme (AAE) consensus motif; other site 1260251003040 AMP binding site [chemical binding]; other site 1260251003041 active site 1260251003042 CoA binding site [chemical binding]; other site 1260251003043 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1260251003044 active site 1260251003045 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1260251003046 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1260251003047 FMN binding site [chemical binding]; other site 1260251003048 active site 1260251003049 catalytic residues [active] 1260251003050 substrate binding site [chemical binding]; other site 1260251003051 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1260251003052 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1260251003053 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1260251003054 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1260251003055 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 1260251003056 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1260251003057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1260251003058 motif II; other site 1260251003059 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1260251003060 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1260251003061 active site 1260251003062 catalytic residues [active] 1260251003063 FMN binding site [chemical binding]; other site 1260251003064 quinone interaction residues [chemical binding]; other site 1260251003065 substrate binding site [chemical binding]; other site 1260251003066 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1260251003067 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1260251003068 P-loop; other site 1260251003069 Magnesium ion binding site [ion binding]; other site 1260251003070 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1260251003071 Magnesium ion binding site [ion binding]; other site 1260251003072 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1260251003073 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1260251003074 carboxy-terminal protease; Provisional; Region: PRK11186 1260251003075 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1260251003076 protein binding site [polypeptide binding]; other site 1260251003077 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1260251003078 Catalytic dyad [active] 1260251003079 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1260251003080 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1260251003081 DHH family; Region: DHH; pfam01368 1260251003082 DHHA1 domain; Region: DHHA1; pfam02272 1260251003083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 1260251003084 threonine synthase; Reviewed; Region: PRK06721 1260251003085 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1260251003086 homodimer interface [polypeptide binding]; other site 1260251003087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251003088 catalytic residue [active] 1260251003089 homoserine dehydrogenase; Provisional; Region: PRK06349 1260251003090 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1260251003091 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1260251003092 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1260251003093 aminotransferase; Validated; Region: PRK08175 1260251003094 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1260251003095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251003096 homodimer interface [polypeptide binding]; other site 1260251003097 catalytic residue [active] 1260251003098 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 1260251003099 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1260251003100 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1260251003101 Peptidase family M23; Region: Peptidase_M23; pfam01551 1260251003102 Predicted membrane protein [Function unknown]; Region: COG1238 1260251003103 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1260251003104 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1260251003105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1260251003106 Smr domain; Region: Smr; pfam01713 1260251003107 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 1260251003108 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1260251003109 Permutation of conserved domain; other site 1260251003110 active site 1260251003111 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1260251003112 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1260251003113 homotrimer interaction site [polypeptide binding]; other site 1260251003114 zinc binding site [ion binding]; other site 1260251003115 CDP-binding sites; other site 1260251003116 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1260251003117 substrate binding site; other site 1260251003118 dimer interface; other site 1260251003119 Septum formation initiator; Region: DivIC; cl17659 1260251003120 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1260251003121 enolase; Provisional; Region: eno; PRK00077 1260251003122 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1260251003123 dimer interface [polypeptide binding]; other site 1260251003124 metal binding site [ion binding]; metal-binding site 1260251003125 substrate binding pocket [chemical binding]; other site 1260251003126 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1260251003127 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1260251003128 CTP synthetase; Validated; Region: pyrG; PRK05380 1260251003129 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1260251003130 Catalytic site [active] 1260251003131 active site 1260251003132 UTP binding site [chemical binding]; other site 1260251003133 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1260251003134 active site 1260251003135 putative oxyanion hole; other site 1260251003136 catalytic triad [active] 1260251003137 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1260251003138 Ligand Binding Site [chemical binding]; other site 1260251003139 TilS substrate binding domain; Region: TilS; pfam09179 1260251003140 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1260251003141 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1260251003142 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1260251003143 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1260251003144 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1260251003145 putative active site [active] 1260251003146 putative PHP Thumb interface [polypeptide binding]; other site 1260251003147 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1260251003148 generic binding surface II; other site 1260251003149 generic binding surface I; other site 1260251003150 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1260251003151 RNA/DNA hybrid binding site [nucleotide binding]; other site 1260251003152 active site 1260251003153 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1260251003154 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1260251003155 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1260251003156 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1260251003157 active site 1260251003158 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1260251003159 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1260251003160 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1260251003161 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1260251003162 trimer interface [polypeptide binding]; other site 1260251003163 active site 1260251003164 UDP-GlcNAc binding site [chemical binding]; other site 1260251003165 lipid binding site [chemical binding]; lipid-binding site 1260251003166 periplasmic chaperone; Provisional; Region: PRK10780 1260251003167 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1260251003168 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1260251003169 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1260251003170 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1260251003171 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1260251003172 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1260251003173 Surface antigen; Region: Bac_surface_Ag; pfam01103 1260251003174 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1260251003175 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1260251003176 active site 1260251003177 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1260251003178 protein binding site [polypeptide binding]; other site 1260251003179 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1260251003180 protein binding site [polypeptide binding]; other site 1260251003181 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1260251003182 putative substrate binding region [chemical binding]; other site 1260251003183 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1260251003184 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1260251003185 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1260251003186 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1260251003187 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1260251003188 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1260251003189 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1260251003190 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1260251003191 catalytic residue [active] 1260251003192 putative FPP diphosphate binding site; other site 1260251003193 putative FPP binding hydrophobic cleft; other site 1260251003194 dimer interface [polypeptide binding]; other site 1260251003195 putative IPP diphosphate binding site; other site 1260251003196 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1260251003197 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1260251003198 hinge region; other site 1260251003199 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1260251003200 putative nucleotide binding site [chemical binding]; other site 1260251003201 uridine monophosphate binding site [chemical binding]; other site 1260251003202 homohexameric interface [polypeptide binding]; other site 1260251003203 elongation factor Ts; Provisional; Region: tsf; PRK09377 1260251003204 UBA/TS-N domain; Region: UBA; pfam00627 1260251003205 Elongation factor TS; Region: EF_TS; pfam00889 1260251003206 Elongation factor TS; Region: EF_TS; pfam00889 1260251003207 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1260251003208 rRNA interaction site [nucleotide binding]; other site 1260251003209 S8 interaction site; other site 1260251003210 putative laminin-1 binding site; other site 1260251003211 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1260251003212 active site 1260251003213 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 1260251003214 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1260251003215 metal binding triad; other site 1260251003216 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1260251003217 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1260251003218 Zn2+ binding site [ion binding]; other site 1260251003219 Mg2+ binding site [ion binding]; other site 1260251003220 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1260251003221 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1260251003222 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 1260251003223 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1260251003224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251003225 homodimer interface [polypeptide binding]; other site 1260251003226 catalytic residue [active] 1260251003227 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1260251003228 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1260251003229 active site 1260251003230 substrate binding site [chemical binding]; other site 1260251003231 trimer interface [polypeptide binding]; other site 1260251003232 CoA binding site [chemical binding]; other site 1260251003233 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1260251003234 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1260251003235 metal binding site [ion binding]; metal-binding site 1260251003236 dimer interface [polypeptide binding]; other site 1260251003237 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1260251003238 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1260251003239 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1260251003240 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1260251003241 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1260251003242 chaperone protein DnaJ; Provisional; Region: PRK10767 1260251003243 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1260251003244 HSP70 interaction site [polypeptide binding]; other site 1260251003245 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1260251003246 substrate binding site [polypeptide binding]; other site 1260251003247 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1260251003248 Zn binding sites [ion binding]; other site 1260251003249 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1260251003250 dimer interface [polypeptide binding]; other site 1260251003251 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1260251003252 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1260251003253 nucleotide binding site [chemical binding]; other site 1260251003254 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1260251003255 GrpE; Region: GrpE; pfam01025 1260251003256 dimer interface [polypeptide binding]; other site 1260251003257 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1260251003258 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1260251003259 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1260251003260 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1260251003261 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1260251003262 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1260251003263 Walker A/P-loop; other site 1260251003264 ATP binding site [chemical binding]; other site 1260251003265 Q-loop/lid; other site 1260251003266 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1260251003267 Q-loop/lid; other site 1260251003268 ABC transporter signature motif; other site 1260251003269 Walker B; other site 1260251003270 D-loop; other site 1260251003271 H-loop/switch region; other site 1260251003272 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1260251003273 metal binding site 2 [ion binding]; metal-binding site 1260251003274 putative DNA binding helix; other site 1260251003275 metal binding site 1 [ion binding]; metal-binding site 1260251003276 dimer interface [polypeptide binding]; other site 1260251003277 structural Zn2+ binding site [ion binding]; other site 1260251003278 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1260251003279 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1260251003280 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1260251003281 RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658 1260251003282 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1260251003283 putative coenzyme Q binding site [chemical binding]; other site 1260251003284 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1260251003285 SmpB-tmRNA interface; other site 1260251003286 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1260251003287 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1260251003288 putative active site [active] 1260251003289 PhoH-like protein; Region: PhoH; pfam02562 1260251003290 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1260251003291 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1260251003292 active site clefts [active] 1260251003293 zinc binding site [ion binding]; other site 1260251003294 dimer interface [polypeptide binding]; other site 1260251003295 classical (c) SDRs; Region: SDR_c; cd05233 1260251003296 NAD(P) binding site [chemical binding]; other site 1260251003297 active site 1260251003298 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 1260251003299 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1260251003300 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1260251003301 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1260251003302 putative NAD(P) binding site [chemical binding]; other site 1260251003303 putative substrate binding site [chemical binding]; other site 1260251003304 catalytic Zn binding site [ion binding]; other site 1260251003305 structural Zn binding site [ion binding]; other site 1260251003306 dimer interface [polypeptide binding]; other site 1260251003307 hypothetical protein; Provisional; Region: PRK11019 1260251003308 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 1260251003309 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1260251003310 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1260251003311 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1260251003312 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1260251003313 DctM-like transporters; Region: DctM; pfam06808 1260251003314 Predicted transcriptional regulator [Transcription]; Region: COG2378 1260251003315 WYL domain; Region: WYL; pfam13280 1260251003316 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1260251003317 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1260251003318 Walker A/P-loop; other site 1260251003319 ATP binding site [chemical binding]; other site 1260251003320 Q-loop/lid; other site 1260251003321 ABC transporter signature motif; other site 1260251003322 Walker B; other site 1260251003323 D-loop; other site 1260251003324 H-loop/switch region; other site 1260251003325 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1260251003326 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1260251003327 Walker A/P-loop; other site 1260251003328 ATP binding site [chemical binding]; other site 1260251003329 Q-loop/lid; other site 1260251003330 ABC transporter signature motif; other site 1260251003331 Walker B; other site 1260251003332 D-loop; other site 1260251003333 H-loop/switch region; other site 1260251003334 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1260251003335 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1260251003336 TM-ABC transporter signature motif; other site 1260251003337 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1260251003338 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1260251003339 TM-ABC transporter signature motif; other site 1260251003340 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1260251003341 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1260251003342 putative ligand binding site [chemical binding]; other site 1260251003343 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1260251003344 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1260251003345 UreF; Region: UreF; pfam01730 1260251003346 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1260251003347 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1260251003348 dimer interface [polypeptide binding]; other site 1260251003349 catalytic residues [active] 1260251003350 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1260251003351 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1260251003352 subunit interactions [polypeptide binding]; other site 1260251003353 active site 1260251003354 flap region; other site 1260251003355 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1260251003356 gamma-beta subunit interface [polypeptide binding]; other site 1260251003357 alpha-beta subunit interface [polypeptide binding]; other site 1260251003358 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1260251003359 alpha-gamma subunit interface [polypeptide binding]; other site 1260251003360 beta-gamma subunit interface [polypeptide binding]; other site 1260251003361 UreD urease accessory protein; Region: UreD; pfam01774 1260251003362 Fic family protein [Function unknown]; Region: COG3177 1260251003363 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 1260251003364 Fic/DOC family; Region: Fic; pfam02661 1260251003365 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1260251003366 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1260251003367 Zn binding site [ion binding]; other site 1260251003368 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1260251003369 Zn binding site [ion binding]; other site 1260251003370 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1260251003371 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1260251003372 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1260251003373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1260251003374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1260251003375 S-adenosylmethionine binding site [chemical binding]; other site 1260251003376 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1260251003377 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1260251003378 non-specific DNA binding site [nucleotide binding]; other site 1260251003379 salt bridge; other site 1260251003380 sequence-specific DNA binding site [nucleotide binding]; other site 1260251003381 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1260251003382 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1260251003383 putative active site [active] 1260251003384 HNH endonuclease; Region: HNH_2; pfam13391 1260251003385 Protein of unknown function DUF262; Region: DUF262; pfam03235 1260251003386 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1260251003387 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1260251003388 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 1260251003389 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 1260251003390 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1260251003391 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1260251003392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1260251003393 S-adenosylmethionine binding site [chemical binding]; other site 1260251003394 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1260251003395 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1260251003396 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1260251003397 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1260251003398 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1260251003399 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1260251003400 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1260251003401 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1260251003402 catalytic core [active] 1260251003403 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1260251003404 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1260251003405 Beta-lactamase; Region: Beta-lactamase; pfam00144 1260251003406 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1260251003407 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1260251003408 homodimer interface [polypeptide binding]; other site 1260251003409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251003410 catalytic residue [active] 1260251003411 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 1260251003412 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 1260251003413 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1260251003414 catalytic Zn binding site [ion binding]; other site 1260251003415 structural Zn binding site [ion binding]; other site 1260251003416 NAD(P) binding site [chemical binding]; other site 1260251003417 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1260251003418 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 1260251003419 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1260251003420 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1260251003421 catalytic core [active] 1260251003422 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 1260251003423 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 1260251003424 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1260251003425 substrate binding pocket [chemical binding]; other site 1260251003426 aspartate-rich region 1; other site 1260251003427 phytoene desaturase; Region: crtI_fam; TIGR02734 1260251003428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1260251003429 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1260251003430 active site lid residues [active] 1260251003431 substrate binding pocket [chemical binding]; other site 1260251003432 catalytic residues [active] 1260251003433 substrate-Mg2+ binding site; other site 1260251003434 aspartate-rich region 1; other site 1260251003435 aspartate-rich region 2; other site 1260251003436 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 1260251003437 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1260251003438 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 1260251003439 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1260251003440 tetramerization interface [polypeptide binding]; other site 1260251003441 active site 1260251003442 ABC transporter ATPase component; Reviewed; Region: PRK11147 1260251003443 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1260251003444 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1260251003445 ABC transporter; Region: ABC_tran_2; pfam12848 1260251003446 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1260251003447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1260251003448 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1260251003449 putative substrate translocation pore; other site 1260251003450 EamA-like transporter family; Region: EamA; pfam00892 1260251003451 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 1260251003452 mercuric reductase; Validated; Region: PRK06370 1260251003453 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1260251003454 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1260251003455 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1260251003456 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1260251003457 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1260251003458 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1260251003459 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1260251003460 FeS/SAM binding site; other site 1260251003461 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1260251003462 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1260251003463 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1260251003464 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1260251003465 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1260251003466 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1260251003467 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1260251003468 Walker A/P-loop; other site 1260251003469 ATP binding site [chemical binding]; other site 1260251003470 Q-loop/lid; other site 1260251003471 ABC transporter signature motif; other site 1260251003472 Walker B; other site 1260251003473 D-loop; other site 1260251003474 H-loop/switch region; other site 1260251003475 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1260251003476 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1260251003477 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1260251003478 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 1260251003479 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1260251003480 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1260251003481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1260251003482 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1260251003483 dimerization interface [polypeptide binding]; other site 1260251003484 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1260251003485 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1260251003486 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1260251003487 FAD binding site [chemical binding]; other site 1260251003488 acyl-CoA synthetase; Validated; Region: PRK08162 1260251003489 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1260251003490 acyl-activating enzyme (AAE) consensus motif; other site 1260251003491 putative active site [active] 1260251003492 AMP binding site [chemical binding]; other site 1260251003493 putative CoA binding site [chemical binding]; other site 1260251003494 enoyl-CoA hydratase; Validated; Region: PRK08139 1260251003495 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1260251003496 substrate binding site [chemical binding]; other site 1260251003497 oxyanion hole (OAH) forming residues; other site 1260251003498 trimer interface [polypeptide binding]; other site 1260251003499 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1260251003500 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1260251003501 Predicted permeases [General function prediction only]; Region: COG0701 1260251003502 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1260251003503 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1260251003504 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1260251003505 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1260251003506 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1260251003507 AAA domain; Region: AAA_30; pfam13604 1260251003508 Family description; Region: UvrD_C_2; pfam13538 1260251003509 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1260251003510 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1260251003511 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1260251003512 nucleophilic elbow; other site 1260251003513 catalytic triad; other site 1260251003514 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1260251003515 active site 1260251003516 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 1260251003517 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1260251003518 Copper resistance protein D; Region: CopD; cl00563 1260251003519 CopC domain; Region: CopC; pfam04234 1260251003520 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 1260251003521 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1260251003522 NMT1-like family; Region: NMT1_2; pfam13379 1260251003523 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1260251003524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1260251003525 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1260251003526 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1260251003527 Walker A/P-loop; other site 1260251003528 ATP binding site [chemical binding]; other site 1260251003529 Q-loop/lid; other site 1260251003530 ABC transporter signature motif; other site 1260251003531 Walker B; other site 1260251003532 D-loop; other site 1260251003533 H-loop/switch region; other site 1260251003534 DsrE/DsrF-like family; Region: DrsE; pfam02635 1260251003535 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1260251003536 substrate binding site [chemical binding]; other site 1260251003537 BCCT family transporter; Region: BCCT; pfam02028 1260251003538 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1260251003539 S-formylglutathione hydrolase; Region: PLN02442 1260251003540 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1260251003541 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1260251003542 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1260251003543 substrate binding site [chemical binding]; other site 1260251003544 catalytic Zn binding site [ion binding]; other site 1260251003545 NAD binding site [chemical binding]; other site 1260251003546 structural Zn binding site [ion binding]; other site 1260251003547 dimer interface [polypeptide binding]; other site 1260251003548 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495 1260251003549 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1260251003550 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1260251003551 acyl-activating enzyme (AAE) consensus motif; other site 1260251003552 AMP binding site [chemical binding]; other site 1260251003553 active site 1260251003554 CoA binding site [chemical binding]; other site 1260251003555 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1260251003556 BioY family; Region: BioY; pfam02632 1260251003557 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1260251003558 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1260251003559 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1260251003560 DctM-like transporters; Region: DctM; pfam06808 1260251003561 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1260251003562 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 1260251003563 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1260251003564 putative active site [active] 1260251003565 metal binding site [ion binding]; metal-binding site 1260251003566 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1260251003567 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1260251003568 substrate binding pocket [chemical binding]; other site 1260251003569 membrane-bound complex binding site; other site 1260251003570 hinge residues; other site 1260251003571 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1260251003572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1260251003573 active site 1260251003574 phosphorylation site [posttranslational modification] 1260251003575 intermolecular recognition site; other site 1260251003576 dimerization interface [polypeptide binding]; other site 1260251003577 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1260251003578 DNA binding residues [nucleotide binding] 1260251003579 dimerization interface [polypeptide binding]; other site 1260251003580 Rrf2 family protein; Region: rrf2_super; TIGR00738 1260251003581 Transcriptional regulator; Region: Rrf2; cl17282 1260251003582 Protein of unknown function (DUF1249); Region: DUF1249; pfam06853 1260251003583 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1260251003584 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1260251003585 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1260251003586 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1260251003587 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1260251003588 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1260251003589 FAD binding domain; Region: FAD_binding_4; pfam01565 1260251003590 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1260251003591 FAD binding domain; Region: FAD_binding_4; pfam01565 1260251003592 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1260251003593 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1260251003594 Cysteine-rich domain; Region: CCG; pfam02754 1260251003595 Cysteine-rich domain; Region: CCG; pfam02754 1260251003596 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1260251003597 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1260251003598 active site residue [active] 1260251003599 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1260251003600 active site residue [active] 1260251003601 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1260251003602 catalytic site [active] 1260251003603 putative active site [active] 1260251003604 putative substrate binding site [chemical binding]; other site 1260251003605 dimer interface [polypeptide binding]; other site 1260251003606 Predicted GTPases [General function prediction only]; Region: COG1162 1260251003607 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1260251003608 RNA binding site [nucleotide binding]; other site 1260251003609 homodimer interface [polypeptide binding]; other site 1260251003610 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1260251003611 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1260251003612 GTP/Mg2+ binding site [chemical binding]; other site 1260251003613 G4 box; other site 1260251003614 G5 box; other site 1260251003615 G1 box; other site 1260251003616 Switch I region; other site 1260251003617 G2 box; other site 1260251003618 G3 box; other site 1260251003619 Switch II region; other site 1260251003620 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1260251003621 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1260251003622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1260251003623 dimer interface [polypeptide binding]; other site 1260251003624 conserved gate region; other site 1260251003625 putative PBP binding loops; other site 1260251003626 ABC-ATPase subunit interface; other site 1260251003627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1260251003628 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1260251003629 Walker A/P-loop; other site 1260251003630 ATP binding site [chemical binding]; other site 1260251003631 Q-loop/lid; other site 1260251003632 ABC transporter signature motif; other site 1260251003633 Walker B; other site 1260251003634 D-loop; other site 1260251003635 H-loop/switch region; other site 1260251003636 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1260251003637 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1260251003638 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1260251003639 heme binding site [chemical binding]; other site 1260251003640 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1260251003641 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 1260251003642 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1260251003643 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1260251003644 dimer interface [polypeptide binding]; other site 1260251003645 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1260251003646 catalytic triad [active] 1260251003647 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1260251003648 nucleotide binding site/active site [active] 1260251003649 HIT family signature motif; other site 1260251003650 catalytic residue [active] 1260251003651 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1260251003652 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1260251003653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1260251003654 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1260251003655 dimerization interface [polypeptide binding]; other site 1260251003656 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1260251003657 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1260251003658 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1260251003659 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1260251003660 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 1260251003661 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1260251003662 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1260251003663 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1260251003664 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1260251003665 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1260251003666 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1260251003667 NAD(P) binding site [chemical binding]; other site 1260251003668 catalytic residues [active] 1260251003669 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1260251003670 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1260251003671 [2Fe-2S] cluster binding site [ion binding]; other site 1260251003672 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1260251003673 alpha subunit interface [polypeptide binding]; other site 1260251003674 active site 1260251003675 substrate binding site [chemical binding]; other site 1260251003676 Fe binding site [ion binding]; other site 1260251003677 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1260251003678 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1260251003679 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1260251003680 dimerization interface [polypeptide binding]; other site 1260251003681 substrate binding pocket [chemical binding]; other site 1260251003682 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1260251003683 EamA-like transporter family; Region: EamA; pfam00892 1260251003684 Predicted metal-binding protein [General function prediction only]; Region: COG3019 1260251003685 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1260251003686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1260251003687 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1260251003688 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1260251003689 Walker A/P-loop; other site 1260251003690 ATP binding site [chemical binding]; other site 1260251003691 Q-loop/lid; other site 1260251003692 ABC transporter signature motif; other site 1260251003693 Walker B; other site 1260251003694 D-loop; other site 1260251003695 H-loop/switch region; other site 1260251003696 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1260251003697 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1260251003698 substrate binding pocket [chemical binding]; other site 1260251003699 membrane-bound complex binding site; other site 1260251003700 hinge residues; other site 1260251003701 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1260251003702 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1260251003703 active site 1260251003704 motif I; other site 1260251003705 motif II; other site 1260251003706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1260251003707 motif I; other site 1260251003708 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1260251003709 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1260251003710 Proline racemase; Region: Pro_racemase; pfam05544 1260251003711 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 1260251003712 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1260251003713 putative NAD(P) binding site [chemical binding]; other site 1260251003714 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1260251003715 nucleoside/Zn binding site; other site 1260251003716 dimer interface [polypeptide binding]; other site 1260251003717 catalytic motif [active] 1260251003718 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1260251003719 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1260251003720 C-terminal domain interface [polypeptide binding]; other site 1260251003721 GSH binding site (G-site) [chemical binding]; other site 1260251003722 dimer interface [polypeptide binding]; other site 1260251003723 GMP synthase; Reviewed; Region: guaA; PRK00074 1260251003724 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1260251003725 AMP/PPi binding site [chemical binding]; other site 1260251003726 candidate oxyanion hole; other site 1260251003727 catalytic triad [active] 1260251003728 potential glutamine specificity residues [chemical binding]; other site 1260251003729 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1260251003730 ATP Binding subdomain [chemical binding]; other site 1260251003731 Ligand Binding sites [chemical binding]; other site 1260251003732 Dimerization subdomain; other site 1260251003733 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1260251003734 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1260251003735 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1260251003736 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1260251003737 active site 1260251003738 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1260251003739 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1260251003740 generic binding surface II; other site 1260251003741 generic binding surface I; other site 1260251003742 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 1260251003743 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 1260251003744 FAD binding pocket [chemical binding]; other site 1260251003745 FAD binding motif [chemical binding]; other site 1260251003746 phosphate binding motif [ion binding]; other site 1260251003747 beta-alpha-beta structure motif; other site 1260251003748 NAD binding pocket [chemical binding]; other site 1260251003749 Iron coordination center [ion binding]; other site 1260251003750 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1260251003751 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1260251003752 active site 1260251003753 hydrophilic channel; other site 1260251003754 dimerization interface [polypeptide binding]; other site 1260251003755 catalytic residues [active] 1260251003756 active site lid [active] 1260251003757 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1260251003758 Recombination protein O N terminal; Region: RecO_N; pfam11967 1260251003759 Recombination protein O C terminal; Region: RecO_C; pfam02565 1260251003760 GTPase Era; Reviewed; Region: era; PRK00089 1260251003761 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1260251003762 G1 box; other site 1260251003763 GTP/Mg2+ binding site [chemical binding]; other site 1260251003764 Switch I region; other site 1260251003765 G2 box; other site 1260251003766 Switch II region; other site 1260251003767 G3 box; other site 1260251003768 G4 box; other site 1260251003769 G5 box; other site 1260251003770 ribonuclease III; Reviewed; Region: rnc; PRK00102 1260251003771 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1260251003772 dimerization interface [polypeptide binding]; other site 1260251003773 active site 1260251003774 metal binding site [ion binding]; metal-binding site 1260251003775 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1260251003776 dsRNA binding site [nucleotide binding]; other site 1260251003777 signal peptidase I; Provisional; Region: PRK10861 1260251003778 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1260251003779 Catalytic site [active] 1260251003780 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1260251003781 GTP-binding protein LepA; Provisional; Region: PRK05433 1260251003782 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1260251003783 G1 box; other site 1260251003784 putative GEF interaction site [polypeptide binding]; other site 1260251003785 GTP/Mg2+ binding site [chemical binding]; other site 1260251003786 Switch I region; other site 1260251003787 G2 box; other site 1260251003788 G3 box; other site 1260251003789 Switch II region; other site 1260251003790 G4 box; other site 1260251003791 G5 box; other site 1260251003792 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1260251003793 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1260251003794 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1260251003795 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1260251003796 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1260251003797 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1260251003798 protein binding site [polypeptide binding]; other site 1260251003799 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1260251003800 protein binding site [polypeptide binding]; other site 1260251003801 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1260251003802 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1260251003803 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1260251003804 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 1260251003805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1260251003806 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1260251003807 DNA binding residues [nucleotide binding] 1260251003808 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 1260251003809 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1260251003810 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1260251003811 catalytic loop [active] 1260251003812 iron binding site [ion binding]; other site 1260251003813 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 1260251003814 L-aspartate oxidase; Provisional; Region: PRK06175 1260251003815 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1260251003816 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 1260251003817 putative SdhC subunit interface [polypeptide binding]; other site 1260251003818 putative proximal heme binding site [chemical binding]; other site 1260251003819 putative Iron-sulfur protein interface [polypeptide binding]; other site 1260251003820 putative proximal quinone binding site; other site 1260251003821 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1260251003822 Iron-sulfur protein interface; other site 1260251003823 proximal quinone binding site [chemical binding]; other site 1260251003824 SdhD (CybS) interface [polypeptide binding]; other site 1260251003825 proximal heme binding site [chemical binding]; other site 1260251003826 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 1260251003827 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 1260251003828 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 1260251003829 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1260251003830 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1260251003831 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1260251003832 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1260251003833 dimer interface [polypeptide binding]; other site 1260251003834 putative anticodon binding site; other site 1260251003835 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1260251003836 motif 1; other site 1260251003837 active site 1260251003838 motif 2; other site 1260251003839 motif 3; other site 1260251003840 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1260251003841 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1260251003842 RF-1 domain; Region: RF-1; pfam00472 1260251003843 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1260251003844 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1260251003845 ATP binding site [chemical binding]; other site 1260251003846 putative Mg++ binding site [ion binding]; other site 1260251003847 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1260251003848 nucleotide binding region [chemical binding]; other site 1260251003849 ATP-binding site [chemical binding]; other site 1260251003850 Helicase associated domain (HA2); Region: HA2; pfam04408 1260251003851 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1260251003852 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1260251003853 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1260251003854 active site 1260251003855 metal binding site [ion binding]; metal-binding site 1260251003856 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1260251003857 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1260251003858 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1260251003859 motif II; other site 1260251003860 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1260251003861 YccA-like proteins; Region: YccA_like; cd10433 1260251003862 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1260251003863 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1260251003864 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1260251003865 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1260251003866 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1260251003867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1260251003868 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1260251003869 substrate binding site [chemical binding]; other site 1260251003870 dimerization interface [polypeptide binding]; other site 1260251003871 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1260251003872 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1260251003873 ligand binding site [chemical binding]; other site 1260251003874 flexible hinge region; other site 1260251003875 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1260251003876 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1260251003877 metal binding triad; other site 1260251003878 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1260251003879 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1260251003880 active site 1260251003881 catalytic site [active] 1260251003882 substrate binding site [chemical binding]; other site 1260251003883 BCCT family transporter; Region: BCCT; pfam02028 1260251003884 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1260251003885 Ligand Binding Site [chemical binding]; other site 1260251003886 recombination protein RecR; Reviewed; Region: recR; PRK00076 1260251003887 RecR protein; Region: RecR; pfam02132 1260251003888 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1260251003889 putative active site [active] 1260251003890 putative metal-binding site [ion binding]; other site 1260251003891 tetramer interface [polypeptide binding]; other site 1260251003892 hypothetical protein; Validated; Region: PRK00153 1260251003893 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969 1260251003894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251003895 Walker A motif; other site 1260251003896 ATP binding site [chemical binding]; other site 1260251003897 Walker B motif; other site 1260251003898 arginine finger; other site 1260251003899 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1260251003900 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1260251003901 Chromate transporter; Region: Chromate_transp; pfam02417 1260251003902 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1260251003903 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1260251003904 glucosyltransferase MdoH; Provisional; Region: PRK05454 1260251003905 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1260251003906 active site 1260251003907 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1260251003908 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1260251003909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251003910 Walker A motif; other site 1260251003911 ATP binding site [chemical binding]; other site 1260251003912 Walker B motif; other site 1260251003913 arginine finger; other site 1260251003914 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1260251003915 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1260251003916 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1260251003917 active site 1260251003918 putative substrate binding pocket [chemical binding]; other site 1260251003919 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1260251003920 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1260251003921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251003922 catalytic residue [active] 1260251003923 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1260251003924 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1260251003925 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1260251003926 HIGH motif; other site 1260251003927 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1260251003928 active site 1260251003929 KMSKS motif; other site 1260251003930 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1260251003931 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1260251003932 active site 1260251003933 catalytic tetrad [active] 1260251003934 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1260251003935 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1260251003936 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1260251003937 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1260251003938 dimerization interface [polypeptide binding]; other site 1260251003939 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1260251003940 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1260251003941 active site 1260251003942 metal binding site [ion binding]; metal-binding site 1260251003943 DNA binding site [nucleotide binding] 1260251003944 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1260251003945 AAA domain; Region: AAA_23; pfam13476 1260251003946 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1260251003947 MutS domain I; Region: MutS_I; pfam01624 1260251003948 MutS domain II; Region: MutS_II; pfam05188 1260251003949 MutS domain III; Region: MutS_III; pfam05192 1260251003950 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1260251003951 Walker A/P-loop; other site 1260251003952 ATP binding site [chemical binding]; other site 1260251003953 Q-loop/lid; other site 1260251003954 ABC transporter signature motif; other site 1260251003955 Walker B; other site 1260251003956 D-loop; other site 1260251003957 H-loop/switch region; other site 1260251003958 Ferredoxin [Energy production and conversion]; Region: COG1146 1260251003959 4Fe-4S binding domain; Region: Fer4; cl02805 1260251003960 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1260251003961 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1260251003962 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1260251003963 active site 1260251003964 Int/Topo IB signature motif; other site 1260251003965 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1260251003966 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1260251003967 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1260251003968 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1260251003969 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1260251003970 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1260251003971 Walker A/P-loop; other site 1260251003972 ATP binding site [chemical binding]; other site 1260251003973 Q-loop/lid; other site 1260251003974 ABC transporter signature motif; other site 1260251003975 Walker B; other site 1260251003976 D-loop; other site 1260251003977 H-loop/switch region; other site 1260251003978 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1260251003979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1260251003980 dimer interface [polypeptide binding]; other site 1260251003981 conserved gate region; other site 1260251003982 putative PBP binding loops; other site 1260251003983 ABC-ATPase subunit interface; other site 1260251003984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1260251003985 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1260251003986 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1260251003987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251003988 homodimer interface [polypeptide binding]; other site 1260251003989 catalytic residue [active] 1260251003990 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1260251003991 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1260251003992 hypothetical protein; Provisional; Region: PRK11212 1260251003993 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1260251003994 seryl-tRNA synthetase; Provisional; Region: PRK05431 1260251003995 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1260251003996 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1260251003997 dimer interface [polypeptide binding]; other site 1260251003998 active site 1260251003999 motif 1; other site 1260251004000 motif 2; other site 1260251004001 motif 3; other site 1260251004002 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1260251004003 recombination factor protein RarA; Reviewed; Region: PRK13342 1260251004004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251004005 Walker A motif; other site 1260251004006 ATP binding site [chemical binding]; other site 1260251004007 Walker B motif; other site 1260251004008 arginine finger; other site 1260251004009 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1260251004010 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1260251004011 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1260251004012 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1260251004013 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1260251004014 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1260251004015 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1260251004016 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1260251004017 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1260251004018 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1260251004019 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1260251004020 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1260251004021 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1260251004022 rRNA binding site [nucleotide binding]; other site 1260251004023 predicted 30S ribosome binding site; other site 1260251004024 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1260251004025 Clp amino terminal domain; Region: Clp_N; pfam02861 1260251004026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251004027 Walker A motif; other site 1260251004028 ATP binding site [chemical binding]; other site 1260251004029 Walker B motif; other site 1260251004030 arginine finger; other site 1260251004031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1260251004032 Walker A motif; other site 1260251004033 ATP binding site [chemical binding]; other site 1260251004034 Walker B motif; other site 1260251004035 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1260251004036 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1260251004037 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1260251004038 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1260251004039 Ligand Binding Site [chemical binding]; other site 1260251004040 putative lysogenization regulator; Reviewed; Region: PRK00218 1260251004041 aconitate hydratase; Validated; Region: PRK09277 1260251004042 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1260251004043 substrate binding site [chemical binding]; other site 1260251004044 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1260251004045 ligand binding site [chemical binding]; other site 1260251004046 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1260251004047 substrate binding site [chemical binding]; other site 1260251004048 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1260251004049 Amidase; Region: Amidase; pfam01425 1260251004050 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1260251004051 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1260251004052 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1260251004053 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1260251004054 malate synthase G; Provisional; Region: PRK02999 1260251004055 active site 1260251004056 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1260251004057 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1260251004058 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1260251004059 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1260251004060 polyphosphate kinase; Provisional; Region: PRK05443 1260251004061 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1260251004062 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1260251004063 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1260251004064 putative active site [active] 1260251004065 catalytic site [active] 1260251004066 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1260251004067 putative domain interface [polypeptide binding]; other site 1260251004068 putative active site [active] 1260251004069 catalytic site [active] 1260251004070 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1260251004071 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1260251004072 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1260251004073 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1260251004074 metal binding site [ion binding]; metal-binding site 1260251004075 active site 1260251004076 I-site; other site 1260251004077 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 1260251004078 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1260251004079 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1260251004080 generic binding surface I; other site 1260251004081 generic binding surface II; other site 1260251004082 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1260251004083 putative catalytic site [active] 1260251004084 putative metal binding site [ion binding]; other site 1260251004085 putative phosphate binding site [ion binding]; other site 1260251004086 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1260251004087 HD domain; Region: HD_4; pfam13328 1260251004088 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1260251004089 synthetase active site [active] 1260251004090 NTP binding site [chemical binding]; other site 1260251004091 metal binding site [ion binding]; metal-binding site 1260251004092 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1260251004093 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1260251004094 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1260251004095 LexA repressor; Validated; Region: PRK00215 1260251004096 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1260251004097 Catalytic site [active] 1260251004098 Uncharacterized conserved protein [Function unknown]; Region: COG4544 1260251004099 DNA Polymerase Y-family; Region: PolY_like; cd03468 1260251004100 active site 1260251004101 DNA binding site [nucleotide binding] 1260251004102 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1260251004103 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1260251004104 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1260251004105 putative active site [active] 1260251004106 putative PHP Thumb interface [polypeptide binding]; other site 1260251004107 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1260251004108 generic binding surface II; other site 1260251004109 generic binding surface I; other site 1260251004110 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1260251004111 putative Mg++ binding site [ion binding]; other site 1260251004112 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1260251004113 nucleotide binding region [chemical binding]; other site 1260251004114 ATP-binding site [chemical binding]; other site 1260251004115 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1260251004116 HRDC domain; Region: HRDC; pfam00570 1260251004117 2-isopropylmalate synthase; Validated; Region: PRK03739 1260251004118 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1260251004119 active site 1260251004120 catalytic residues [active] 1260251004121 metal binding site [ion binding]; metal-binding site 1260251004122 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1260251004123 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1260251004124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1260251004125 Walker A/P-loop; other site 1260251004126 ATP binding site [chemical binding]; other site 1260251004127 Q-loop/lid; other site 1260251004128 ABC transporter signature motif; other site 1260251004129 Walker B; other site 1260251004130 D-loop; other site 1260251004131 H-loop/switch region; other site 1260251004132 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1260251004133 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 1260251004134 Helicase; Region: Helicase_RecD; pfam05127 1260251004135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1260251004136 Coenzyme A binding pocket [chemical binding]; other site 1260251004137 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1260251004138 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1260251004139 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1260251004140 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1260251004141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1260251004142 Walker A/P-loop; other site 1260251004143 ATP binding site [chemical binding]; other site 1260251004144 Q-loop/lid; other site 1260251004145 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1260251004146 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1260251004147 Domain of unknown function (DUF336); Region: DUF336; cl01249 1260251004148 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis]; Region: COG1188 1260251004149 RNA binding surface [nucleotide binding]; other site 1260251004150 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1260251004151 FOG: CBS domain [General function prediction only]; Region: COG0517 1260251004152 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1260251004153 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1260251004154 AAA domain; Region: AAA_18; pfam13238 1260251004155 active site 1260251004156 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1260251004157 nucleophile elbow; other site 1260251004158 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1260251004159 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1260251004160 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1260251004161 putative NAD(P) binding site [chemical binding]; other site 1260251004162 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1260251004163 active site 1260251004164 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1260251004165 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1260251004166 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1260251004167 S-adenosylmethionine binding site [chemical binding]; other site 1260251004168 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1260251004169 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1260251004170 RibD C-terminal domain; Region: RibD_C; pfam01872 1260251004171 GTP cyclohydrolase; Provisional; Region: PRK08815 1260251004172 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1260251004173 dimerization interface [polypeptide binding]; other site 1260251004174 active site 1260251004175 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1260251004176 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 1260251004177 ligand binding site [chemical binding]; other site 1260251004178 ProQ/FINO family; Region: ProQ; pfam04352 1260251004179 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1260251004180 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1260251004181 intersubunit interface [polypeptide binding]; other site 1260251004182 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1260251004183 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1260251004184 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1260251004185 TrkA-C domain; Region: TrkA_C; pfam02080 1260251004186 TrkA-C domain; Region: TrkA_C; pfam02080 1260251004187 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1260251004188 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 1260251004189 hypothetical protein; Provisional; Region: PRK07907 1260251004190 metal binding site [ion binding]; metal-binding site 1260251004191 putative dimer interface [polypeptide binding]; other site 1260251004192 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1260251004193 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1260251004194 NADP binding site [chemical binding]; other site 1260251004195 homodimer interface [polypeptide binding]; other site 1260251004196 active site 1260251004197 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 1260251004198 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1260251004199 ATP-dependent DNA ligase; Validated; Region: PRK09247 1260251004200 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 1260251004201 active site 1260251004202 DNA binding site [nucleotide binding] 1260251004203 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1260251004204 DNA binding site [nucleotide binding] 1260251004205 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 1260251004206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1260251004207 ATP binding site [chemical binding]; other site 1260251004208 putative Mg++ binding site [ion binding]; other site 1260251004209 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1260251004210 nucleotide binding region [chemical binding]; other site 1260251004211 ATP-binding site [chemical binding]; other site 1260251004212 DEAD/H associated; Region: DEAD_assoc; pfam08494 1260251004213 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 1260251004214 putative active site [active] 1260251004215 putative metal binding site [ion binding]; other site 1260251004216 Ion transport protein; Region: Ion_trans; pfam00520 1260251004217 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 1260251004218 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 1260251004219 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1260251004220 Peptidase family M23; Region: Peptidase_M23; pfam01551 1260251004221 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1260251004222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1260251004223 S-adenosylmethionine binding site [chemical binding]; other site 1260251004224 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1260251004225 metal binding site 2 [ion binding]; metal-binding site 1260251004226 putative DNA binding helix; other site 1260251004227 metal binding site 1 [ion binding]; metal-binding site 1260251004228 dimer interface [polypeptide binding]; other site 1260251004229 structural Zn2+ binding site [ion binding]; other site 1260251004230 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1260251004231 Glycoprotease family; Region: Peptidase_M22; pfam00814 1260251004232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1260251004233 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1260251004234 putative substrate translocation pore; other site 1260251004235 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1260251004236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1260251004237 Coenzyme A binding pocket [chemical binding]; other site 1260251004238 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 1260251004239 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1260251004240 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1260251004241 ATP binding site [chemical binding]; other site 1260251004242 DEAD_2; Region: DEAD_2; pfam06733 1260251004243 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1260251004244 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1260251004245 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1260251004246 hypothetical protein; Validated; Region: PRK00029 1260251004247 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1260251004248 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1260251004249 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 1260251004250 gating phenylalanine in ion channel; other site 1260251004251 High potential iron-sulfur protein; Region: HIPIP; pfam01355 1260251004252 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1260251004253 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1260251004254 dimerization domain [polypeptide binding]; other site 1260251004255 dimer interface [polypeptide binding]; other site 1260251004256 catalytic residues [active] 1260251004257 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1260251004258 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1260251004259 homodimer interface [polypeptide binding]; other site 1260251004260 substrate-cofactor binding pocket; other site 1260251004261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251004262 catalytic residue [active] 1260251004263 hypothetical protein; Provisional; Region: PRK10557 1260251004264 TSCPD domain; Region: TSCPD; pfam12637 1260251004265 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1260251004266 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1260251004267 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1260251004268 active site 1260251004269 dimer interface [polypeptide binding]; other site 1260251004270 effector binding site; other site 1260251004271 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1260251004272 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 1260251004273 putative metal binding site [ion binding]; other site 1260251004274 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1260251004275 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1260251004276 catalytic residue [active] 1260251004277 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1260251004278 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1260251004279 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1260251004280 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1260251004281 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1260251004282 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 1260251004283 putative active site [active] 1260251004284 catalytic site [active] 1260251004285 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 1260251004286 putative active site [active] 1260251004287 catalytic site [active] 1260251004288 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1260251004289 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 1260251004290 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 1260251004291 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1260251004292 Na binding site [ion binding]; other site 1260251004293 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1260251004294 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1260251004295 putative MPT binding site; other site 1260251004296 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1260251004297 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1260251004298 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1260251004299 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1260251004300 active site 1260251004301 catalytic site [active] 1260251004302 substrate binding site [chemical binding]; other site 1260251004303 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1260251004304 RNA/DNA hybrid binding site [nucleotide binding]; other site 1260251004305 active site 1260251004306 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1260251004307 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1260251004308 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1260251004309 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1260251004310 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1260251004311 catalytic residue [active] 1260251004312 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1260251004313 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1260251004314 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1260251004315 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1260251004316 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1260251004317 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1260251004318 Switch I; other site 1260251004319 Switch II; other site 1260251004320 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1260251004321 septum formation inhibitor; Reviewed; Region: minC; PRK04804 1260251004322 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1260251004323 heat shock protein 90; Provisional; Region: PRK05218 1260251004324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1260251004325 ATP binding site [chemical binding]; other site 1260251004326 Mg2+ binding site [ion binding]; other site 1260251004327 G-X-G motif; other site 1260251004328 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 1260251004329 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1260251004330 PYR/PP interface [polypeptide binding]; other site 1260251004331 dimer interface [polypeptide binding]; other site 1260251004332 TPP binding site [chemical binding]; other site 1260251004333 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1260251004334 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1260251004335 TPP-binding site [chemical binding]; other site 1260251004336 dimer interface [polypeptide binding]; other site 1260251004337 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1260251004338 SelR domain; Region: SelR; pfam01641 1260251004339 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1260251004340 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1260251004341 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1260251004342 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1260251004343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1260251004344 motif II; other site 1260251004345 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1260251004346 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1260251004347 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 1260251004348 RimM N-terminal domain; Region: RimM; pfam01782 1260251004349 PRC-barrel domain; Region: PRC; pfam05239 1260251004350 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1260251004351 signal recognition particle protein; Provisional; Region: PRK10867 1260251004352 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1260251004353 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1260251004354 P loop; other site 1260251004355 GTP binding site [chemical binding]; other site 1260251004356 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1260251004357 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1260251004358 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1260251004359 Domain of unknown function DUF21; Region: DUF21; pfam01595 1260251004360 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1260251004361 Transporter associated domain; Region: CorC_HlyC; smart01091 1260251004362 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1260251004363 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1260251004364 active site 1260251004365 HIGH motif; other site 1260251004366 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1260251004367 KMSKS motif; other site 1260251004368 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1260251004369 tRNA binding surface [nucleotide binding]; other site 1260251004370 anticodon binding site; other site 1260251004371 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1260251004372 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1260251004373 active site 1260251004374 HIGH motif; other site 1260251004375 nucleotide binding site [chemical binding]; other site 1260251004376 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1260251004377 active site 1260251004378 KMSKS motif; other site 1260251004379 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1260251004380 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1260251004381 putative active site [active] 1260251004382 putative metal binding site [ion binding]; other site 1260251004383 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1260251004384 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1260251004385 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1260251004386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1260251004387 dimer interface [polypeptide binding]; other site 1260251004388 conserved gate region; other site 1260251004389 putative PBP binding loops; other site 1260251004390 ABC-ATPase subunit interface; other site 1260251004391 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1260251004392 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1260251004393 Walker A/P-loop; other site 1260251004394 ATP binding site [chemical binding]; other site 1260251004395 Q-loop/lid; other site 1260251004396 ABC transporter signature motif; other site 1260251004397 Walker B; other site 1260251004398 D-loop; other site 1260251004399 H-loop/switch region; other site 1260251004400 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1260251004401 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1260251004402 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1260251004403 MOFRL family; Region: MOFRL; pfam05161 1260251004404 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 1260251004405 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1260251004406 homodimer interface [polypeptide binding]; other site 1260251004407 substrate-cofactor binding pocket; other site 1260251004408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251004409 catalytic residue [active] 1260251004410 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1260251004411 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1260251004412 active site 1260251004413 tetramer interface [polypeptide binding]; other site 1260251004414 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1260251004415 active site 1260251004416 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1260251004417 Colicin V production protein; Region: Colicin_V; pfam02674 1260251004418 Sporulation related domain; Region: SPOR; pfam05036 1260251004419 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1260251004420 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1260251004421 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1260251004422 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1260251004423 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1260251004424 substrate binding site [chemical binding]; other site 1260251004425 active site 1260251004426 catalytic residues [active] 1260251004427 heterodimer interface [polypeptide binding]; other site 1260251004428 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1260251004429 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1260251004430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251004431 catalytic residue [active] 1260251004432 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1260251004433 active site 1260251004434 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1260251004435 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1260251004436 dimerization interface 3.5A [polypeptide binding]; other site 1260251004437 active site 1260251004438 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1260251004439 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1260251004440 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1260251004441 tartrate dehydrogenase; Region: TTC; TIGR02089 1260251004442 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1260251004443 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1260251004444 substrate binding site [chemical binding]; other site 1260251004445 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1260251004446 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1260251004447 substrate binding site [chemical binding]; other site 1260251004448 ligand binding site [chemical binding]; other site 1260251004449 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1260251004450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1260251004451 putative substrate translocation pore; other site 1260251004452 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1260251004453 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1260251004454 Tetramer interface [polypeptide binding]; other site 1260251004455 active site 1260251004456 FMN-binding site [chemical binding]; other site 1260251004457 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805 1260251004458 HemK family putative methylases; Region: hemK_fam; TIGR00536 1260251004459 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1260251004460 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1260251004461 Cu(I) binding site [ion binding]; other site 1260251004462 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1260251004463 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1260251004464 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 1260251004465 motif 1; other site 1260251004466 dimer interface [polypeptide binding]; other site 1260251004467 active site 1260251004468 motif 2; other site 1260251004469 motif 3; other site 1260251004470 elongation factor P; Validated; Region: PRK00529 1260251004471 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1260251004472 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1260251004473 RNA binding site [nucleotide binding]; other site 1260251004474 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1260251004475 RNA binding site [nucleotide binding]; other site 1260251004476 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1260251004477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1260251004478 FeS/SAM binding site; other site 1260251004479 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1260251004480 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1260251004481 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1260251004482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1260251004483 dimer interface [polypeptide binding]; other site 1260251004484 phosphorylation site [posttranslational modification] 1260251004485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1260251004486 ATP binding site [chemical binding]; other site 1260251004487 Mg2+ binding site [ion binding]; other site 1260251004488 G-X-G motif; other site 1260251004489 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1260251004490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1260251004491 active site 1260251004492 phosphorylation site [posttranslational modification] 1260251004493 intermolecular recognition site; other site 1260251004494 dimerization interface [polypeptide binding]; other site 1260251004495 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1260251004496 DNA binding site [nucleotide binding] 1260251004497 heat shock protein HtpX; Provisional; Region: PRK05457 1260251004498 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1260251004499 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1260251004500 CAP-like domain; other site 1260251004501 active site 1260251004502 primary dimer interface [polypeptide binding]; other site 1260251004503 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1260251004504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1260251004505 Mg2+ binding site [ion binding]; other site 1260251004506 G-X-G motif; other site 1260251004507 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1260251004508 anchoring element; other site 1260251004509 dimer interface [polypeptide binding]; other site 1260251004510 ATP binding site [chemical binding]; other site 1260251004511 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 1260251004512 active site 1260251004513 putative metal-binding site [ion binding]; other site 1260251004514 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1260251004515 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1260251004516 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1260251004517 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1260251004518 substrate binding pocket [chemical binding]; other site 1260251004519 chain length determination region; other site 1260251004520 substrate-Mg2+ binding site; other site 1260251004521 catalytic residues [active] 1260251004522 aspartate-rich region 1; other site 1260251004523 active site lid residues [active] 1260251004524 aspartate-rich region 2; other site 1260251004525 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1260251004526 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1260251004527 G1 box; other site 1260251004528 putative GEF interaction site [polypeptide binding]; other site 1260251004529 GTP/Mg2+ binding site [chemical binding]; other site 1260251004530 Switch I region; other site 1260251004531 G2 box; other site 1260251004532 G3 box; other site 1260251004533 Switch II region; other site 1260251004534 G4 box; other site 1260251004535 G5 box; other site 1260251004536 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1260251004537 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1260251004538 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1260251004539 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1260251004540 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1260251004541 TrkA-N domain; Region: TrkA_N; pfam02254 1260251004542 serine/threonine protein kinase; Provisional; Region: PRK11768 1260251004543 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1260251004544 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1260251004545 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1260251004546 active site 1260251004547 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1260251004548 acetylornithine aminotransferase; Provisional; Region: PRK02627 1260251004549 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1260251004550 inhibitor-cofactor binding pocket; inhibition site 1260251004551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251004552 catalytic residue [active] 1260251004553 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1260251004554 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1260251004555 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1260251004556 transcriptional regulator PhoU; Provisional; Region: PRK11115 1260251004557 PhoU domain; Region: PhoU; pfam01895 1260251004558 PhoU domain; Region: PhoU; pfam01895 1260251004559 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 1260251004560 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1260251004561 Walker A/P-loop; other site 1260251004562 ATP binding site [chemical binding]; other site 1260251004563 Q-loop/lid; other site 1260251004564 ABC transporter signature motif; other site 1260251004565 Walker B; other site 1260251004566 D-loop; other site 1260251004567 H-loop/switch region; other site 1260251004568 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 1260251004569 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1260251004570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1260251004571 dimer interface [polypeptide binding]; other site 1260251004572 conserved gate region; other site 1260251004573 putative PBP binding loops; other site 1260251004574 ABC-ATPase subunit interface; other site 1260251004575 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1260251004576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1260251004577 dimer interface [polypeptide binding]; other site 1260251004578 conserved gate region; other site 1260251004579 putative PBP binding loops; other site 1260251004580 ABC-ATPase subunit interface; other site 1260251004581 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1260251004582 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1260251004583 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1260251004584 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1260251004585 putative active site [active] 1260251004586 heme pocket [chemical binding]; other site 1260251004587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1260251004588 dimer interface [polypeptide binding]; other site 1260251004589 phosphorylation site [posttranslational modification] 1260251004590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1260251004591 ATP binding site [chemical binding]; other site 1260251004592 Mg2+ binding site [ion binding]; other site 1260251004593 G-X-G motif; other site 1260251004594 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1260251004595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1260251004596 active site 1260251004597 phosphorylation site [posttranslational modification] 1260251004598 intermolecular recognition site; other site 1260251004599 dimerization interface [polypeptide binding]; other site 1260251004600 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1260251004601 DNA binding site [nucleotide binding] 1260251004602 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 1260251004603 Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism]; Region: MnhF; COG2212 1260251004604 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 1260251004605 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1260251004606 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1260251004607 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 1260251004608 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1260251004609 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1260251004610 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1260251004611 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1260251004612 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 1260251004613 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1260251004614 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1260251004615 Type II transport protein GspH; Region: GspH; pfam12019 1260251004616 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1260251004617 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1260251004618 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1260251004619 lipoprotein signal peptidase; Provisional; Region: PRK14787 1260251004620 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1260251004621 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1260251004622 active site 1260251004623 HIGH motif; other site 1260251004624 nucleotide binding site [chemical binding]; other site 1260251004625 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1260251004626 active site 1260251004627 KMSKS motif; other site 1260251004628 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1260251004629 tRNA binding surface [nucleotide binding]; other site 1260251004630 anticodon binding site; other site 1260251004631 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1260251004632 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1260251004633 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1260251004634 active site 1260251004635 Riboflavin kinase; Region: Flavokinase; smart00904 1260251004636 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1260251004637 MviN-like protein; Region: MVIN; pfam03023 1260251004638 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1260251004639 gamma-glutamyl kinase; Provisional; Region: PRK05429 1260251004640 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1260251004641 nucleotide binding site [chemical binding]; other site 1260251004642 homotetrameric interface [polypeptide binding]; other site 1260251004643 putative phosphate binding site [ion binding]; other site 1260251004644 putative allosteric binding site; other site 1260251004645 PUA domain; Region: PUA; pfam01472 1260251004646 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1260251004647 GTP1/OBG; Region: GTP1_OBG; pfam01018 1260251004648 Obg GTPase; Region: Obg; cd01898 1260251004649 G1 box; other site 1260251004650 GTP/Mg2+ binding site [chemical binding]; other site 1260251004651 Switch I region; other site 1260251004652 G2 box; other site 1260251004653 G3 box; other site 1260251004654 Switch II region; other site 1260251004655 G4 box; other site 1260251004656 G5 box; other site 1260251004657 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1260251004658 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1260251004659 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1260251004660 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1260251004661 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1260251004662 substrate binding pocket [chemical binding]; other site 1260251004663 chain length determination region; other site 1260251004664 substrate-Mg2+ binding site; other site 1260251004665 catalytic residues [active] 1260251004666 aspartate-rich region 1; other site 1260251004667 active site lid residues [active] 1260251004668 aspartate-rich region 2; other site 1260251004669 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1260251004670 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1260251004671 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1260251004672 Walker A motif; other site 1260251004673 ATP binding site [chemical binding]; other site 1260251004674 Walker B motif; other site 1260251004675 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1260251004676 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1260251004677 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1260251004678 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1260251004679 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1260251004680 CoA-binding site [chemical binding]; other site 1260251004681 ATP-binding [chemical binding]; other site 1260251004682 hypothetical protein; Provisional; Region: PRK05287 1260251004683 Domain of unknown function (DUF329); Region: DUF329; pfam03884 1260251004684 hypothetical protein; Provisional; Region: PRK08999 1260251004685 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1260251004686 active site 1260251004687 8-oxo-dGMP binding site [chemical binding]; other site 1260251004688 nudix motif; other site 1260251004689 metal binding site [ion binding]; metal-binding site 1260251004690 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1260251004691 thiamine phosphate binding site [chemical binding]; other site 1260251004692 active site 1260251004693 pyrophosphate binding site [ion binding]; other site 1260251004694 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1260251004695 heterotetramer interface [polypeptide binding]; other site 1260251004696 active site pocket [active] 1260251004697 cleavage site 1260251004698 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1260251004699 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1260251004700 ATP binding site [chemical binding]; other site 1260251004701 putative Mg++ binding site [ion binding]; other site 1260251004702 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1260251004703 SEC-C motif; Region: SEC-C; pfam02810 1260251004704 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1260251004705 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1260251004706 cell division protein FtsZ; Validated; Region: PRK09330 1260251004707 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1260251004708 nucleotide binding site [chemical binding]; other site 1260251004709 SulA interaction site; other site 1260251004710 cell division protein FtsA; Region: ftsA; TIGR01174 1260251004711 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1260251004712 nucleotide binding site [chemical binding]; other site 1260251004713 Cell division protein FtsA; Region: FtsA; pfam14450 1260251004714 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1260251004715 Cell division protein FtsQ; Region: FtsQ; pfam03799 1260251004716 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1260251004717 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1260251004718 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1260251004719 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1260251004720 FAD binding domain; Region: FAD_binding_4; pfam01565 1260251004721 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1260251004722 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1260251004723 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1260251004724 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1260251004725 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1260251004726 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1260251004727 active site 1260251004728 homodimer interface [polypeptide binding]; other site 1260251004729 cell division protein FtsW; Region: ftsW; TIGR02614 1260251004730 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 1260251004731 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1260251004732 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1260251004733 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1260251004734 Mg++ binding site [ion binding]; other site 1260251004735 putative catalytic motif [active] 1260251004736 putative substrate binding site [chemical binding]; other site 1260251004737 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1260251004738 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1260251004739 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1260251004740 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1260251004741 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1260251004742 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1260251004743 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1260251004744 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1260251004745 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1260251004746 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1260251004747 Cell division protein FtsL; Region: FtsL; pfam04999 1260251004748 MraW methylase family; Region: Methyltransf_5; cl17771 1260251004749 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1260251004750 cell division protein MraZ; Reviewed; Region: PRK00326 1260251004751 MraZ protein; Region: MraZ; pfam02381 1260251004752 MraZ protein; Region: MraZ; pfam02381 1260251004753 Predicted methyltransferases [General function prediction only]; Region: COG0313 1260251004754 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1260251004755 putative SAM binding site [chemical binding]; other site 1260251004756 putative homodimer interface [polypeptide binding]; other site 1260251004757 LppC putative lipoprotein; Region: LppC; pfam04348 1260251004758 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1260251004759 putative ligand binding site [chemical binding]; other site 1260251004760 hypothetical protein; Reviewed; Region: PRK12497 1260251004761 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1260251004762 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1260251004763 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1260251004764 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1260251004765 dimer interface [polypeptide binding]; other site 1260251004766 N-terminal domain interface [polypeptide binding]; other site 1260251004767 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1260251004768 Cytochrome c; Region: Cytochrom_C; pfam00034 1260251004769 cytochrome b; Provisional; Region: CYTB; MTH00145 1260251004770 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1260251004771 Qi binding site; other site 1260251004772 intrachain domain interface; other site 1260251004773 interchain domain interface [polypeptide binding]; other site 1260251004774 heme bH binding site [chemical binding]; other site 1260251004775 heme bL binding site [chemical binding]; other site 1260251004776 Qo binding site; other site 1260251004777 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 1260251004778 interchain domain interface [polypeptide binding]; other site 1260251004779 intrachain domain interface; other site 1260251004780 Qi binding site; other site 1260251004781 Qo binding site; other site 1260251004782 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1260251004783 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1260251004784 [2Fe-2S] cluster binding site [ion binding]; other site 1260251004785 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1260251004786 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1260251004787 serine endoprotease; Provisional; Region: PRK10898 1260251004788 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1260251004789 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1260251004790 protein binding site [polypeptide binding]; other site 1260251004791 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1260251004792 histidinol dehydrogenase; Region: hisD; TIGR00069 1260251004793 NAD binding site [chemical binding]; other site 1260251004794 dimerization interface [polypeptide binding]; other site 1260251004795 product binding site; other site 1260251004796 substrate binding site [chemical binding]; other site 1260251004797 zinc binding site [ion binding]; other site 1260251004798 catalytic residues [active] 1260251004799 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1260251004800 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1260251004801 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1260251004802 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1260251004803 hinge; other site 1260251004804 active site 1260251004805 BolA-like protein; Region: BolA; cl00386 1260251004806 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1260251004807 anti sigma factor interaction site; other site 1260251004808 regulatory phosphorylation site [posttranslational modification]; other site 1260251004809 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1260251004810 mce related protein; Region: MCE; pfam02470 1260251004811 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1260251004812 Permease; Region: Permease; cl00510 1260251004813 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1260251004814 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1260251004815 Walker A/P-loop; other site 1260251004816 ATP binding site [chemical binding]; other site 1260251004817 Q-loop/lid; other site 1260251004818 ABC transporter signature motif; other site 1260251004819 Walker B; other site 1260251004820 D-loop; other site 1260251004821 H-loop/switch region; other site 1260251004822 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1260251004823 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1260251004824 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1260251004825 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1260251004826 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1260251004827 putative active site [active] 1260251004828 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1260251004829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 1260251004830 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1260251004831 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1260251004832 OstA-like protein; Region: OstA; pfam03968 1260251004833 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1260251004834 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1260251004835 Walker A/P-loop; other site 1260251004836 ATP binding site [chemical binding]; other site 1260251004837 Q-loop/lid; other site 1260251004838 ABC transporter signature motif; other site 1260251004839 Walker B; other site 1260251004840 D-loop; other site 1260251004841 H-loop/switch region; other site 1260251004842 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1260251004843 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1260251004844 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1260251004845 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1260251004846 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1260251004847 30S subunit binding site; other site 1260251004848 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1260251004849 active site 1260251004850 phosphorylation site [posttranslational modification] 1260251004851 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1260251004852 Hpr binding site; other site 1260251004853 active site 1260251004854 homohexamer subunit interaction site [polypeptide binding]; other site 1260251004855 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1260251004856 AAA domain; Region: AAA_18; pfam13238 1260251004857 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1260251004858 active pocket/dimerization site; other site 1260251004859 active site 1260251004860 phosphorylation site [posttranslational modification] 1260251004861 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1260251004862 dimerization domain swap beta strand [polypeptide binding]; other site 1260251004863 regulatory protein interface [polypeptide binding]; other site 1260251004864 active site 1260251004865 regulatory phosphorylation site [posttranslational modification]; other site 1260251004866 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1260251004867 MgtE intracellular N domain; Region: MgtE_N; smart00924 1260251004868 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1260251004869 Divalent cation transporter; Region: MgtE; pfam01769 1260251004870 GTP-binding protein YchF; Reviewed; Region: PRK09601 1260251004871 YchF GTPase; Region: YchF; cd01900 1260251004872 G1 box; other site 1260251004873 GTP/Mg2+ binding site [chemical binding]; other site 1260251004874 Switch I region; other site 1260251004875 G2 box; other site 1260251004876 Switch II region; other site 1260251004877 G3 box; other site 1260251004878 G4 box; other site 1260251004879 G5 box; other site 1260251004880 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1260251004881 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1260251004882 putative active site [active] 1260251004883 catalytic residue [active] 1260251004884 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1260251004885 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1260251004886 5S rRNA interface [nucleotide binding]; other site 1260251004887 CTC domain interface [polypeptide binding]; other site 1260251004888 L16 interface [polypeptide binding]; other site 1260251004889 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1260251004890 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1260251004891 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1260251004892 active site 1260251004893 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1260251004894 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1260251004895 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1260251004896 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1260251004897 TPR repeat; Region: TPR_11; pfam13414 1260251004898 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1260251004899 binding surface 1260251004900 TPR motif; other site 1260251004901 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1260251004902 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1260251004903 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1260251004904 tRNA; other site 1260251004905 putative tRNA binding site [nucleotide binding]; other site 1260251004906 putative NADP binding site [chemical binding]; other site 1260251004907 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1260251004908 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1260251004909 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1260251004910 RF-1 domain; Region: RF-1; pfam00472 1260251004911 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1260251004912 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1260251004913 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1260251004914 Trm112p-like protein; Region: Trm112p; cl01066 1260251004915 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1260251004916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1260251004917 S-adenosylmethionine binding site [chemical binding]; other site 1260251004918 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1260251004919 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1260251004920 ATP binding site [chemical binding]; other site 1260251004921 substrate interface [chemical binding]; other site 1260251004922 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1260251004923 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1260251004924 dimerization interface [polypeptide binding]; other site 1260251004925 domain crossover interface; other site 1260251004926 redox-dependent activation switch; other site 1260251004927 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1260251004928 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1260251004929 GatB domain; Region: GatB_Yqey; smart00845 1260251004930 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1260251004931 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1260251004932 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1260251004933 rod shape-determining protein MreB; Provisional; Region: PRK13927 1260251004934 MreB and similar proteins; Region: MreB_like; cd10225 1260251004935 nucleotide binding site [chemical binding]; other site 1260251004936 Mg binding site [ion binding]; other site 1260251004937 putative protofilament interaction site [polypeptide binding]; other site 1260251004938 RodZ interaction site [polypeptide binding]; other site 1260251004939 rod shape-determining protein MreC; Provisional; Region: PRK13922 1260251004940 rod shape-determining protein MreC; Region: MreC; pfam04085 1260251004941 rod shape-determining protein MreD; Region: MreD; cl01087 1260251004942 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1260251004943 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1260251004944 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1260251004945 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1260251004946 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1260251004947 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1260251004948 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1260251004949 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1260251004950 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1260251004951 Sporulation related domain; Region: SPOR; pfam05036 1260251004952 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1260251004953 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1260251004954 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1260251004955 Protein of unknown function (DUF493); Region: DUF493; pfam04359 1260251004956 lipoate-protein ligase B; Provisional; Region: PRK14342 1260251004957 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1260251004958 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1260251004959 Substrate binding site; other site 1260251004960 metal-binding site 1260251004961 Phosphotransferase enzyme family; Region: APH; pfam01636 1260251004962 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1260251004963 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1260251004964 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1260251004965 SurA N-terminal domain; Region: SurA_N; pfam09312 1260251004966 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1260251004967 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1260251004968 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1260251004969 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1260251004970 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1260251004971 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1260251004972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1260251004973 S-adenosylmethionine binding site [chemical binding]; other site 1260251004974 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1260251004975 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1260251004976 active site 1260251004977 metal binding site [ion binding]; metal-binding site 1260251004978 nitrilase; Region: PLN02798 1260251004979 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1260251004980 putative active site [active] 1260251004981 catalytic triad [active] 1260251004982 dimer interface [polypeptide binding]; other site 1260251004983 Predicted membrane protein [Function unknown]; Region: COG3164 1260251004984 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1260251004985 ribonuclease G; Provisional; Region: PRK11712 1260251004986 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1260251004987 homodimer interface [polypeptide binding]; other site 1260251004988 oligonucleotide binding site [chemical binding]; other site 1260251004989 Maf-like protein; Region: Maf; pfam02545 1260251004990 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1260251004991 active site 1260251004992 dimer interface [polypeptide binding]; other site 1260251004993 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1260251004994 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1260251004995 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1260251004996 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1260251004997 active site 1260251004998 (T/H)XGH motif; other site 1260251004999 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1260251005000 putative catalytic cysteine [active] 1260251005001 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1260251005002 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1260251005003 Lipopolysaccharide-assembly; Region: LptE; cl01125 1260251005004 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1260251005005 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1260251005006 HIGH motif; other site 1260251005007 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1260251005008 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1260251005009 active site 1260251005010 KMSKS motif; other site 1260251005011 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1260251005012 tRNA binding surface [nucleotide binding]; other site 1260251005013 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 1260251005014 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1260251005015 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1260251005016 putative active site [active] 1260251005017 catalytic triad [active] 1260251005018 putative dimer interface [polypeptide binding]; other site 1260251005019 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1260251005020 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1260251005021 Transporter associated domain; Region: CorC_HlyC; smart01091 1260251005022 metal-binding heat shock protein; Provisional; Region: PRK00016 1260251005023 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1260251005024 PhoH-like protein; Region: PhoH; pfam02562 1260251005025 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1260251005026 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1260251005027 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1260251005028 FeS/SAM binding site; other site 1260251005029 TRAM domain; Region: TRAM; pfam01938 1260251005030 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1260251005031 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1260251005032 Substrate binding site; other site 1260251005033 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1260251005034 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1260251005035 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1260251005036 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1260251005037 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1260251005038 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1260251005039 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1260251005040 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1260251005041 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1260251005042 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1260251005043 acyl-activating enzyme (AAE) consensus motif; other site 1260251005044 putative AMP binding site [chemical binding]; other site 1260251005045 putative active site [active] 1260251005046 putative CoA binding site [chemical binding]; other site 1260251005047 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1260251005048 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1260251005049 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1260251005050 putative acyl-acceptor binding pocket; other site 1260251005051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1260251005052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1260251005053 dimer interface [polypeptide binding]; other site 1260251005054 ssDNA binding site [nucleotide binding]; other site 1260251005055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1260251005056 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 1260251005057 ATP-sulfurylase; Region: ATPS; cd00517 1260251005058 active site 1260251005059 HXXH motif; other site 1260251005060 flexible loop; other site 1260251005061 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1260251005062 ligand-binding site [chemical binding]; other site 1260251005063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1260251005064 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1260251005065 putative substrate translocation pore; other site 1260251005066 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1260251005067 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1260251005068 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1260251005069 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1260251005070 malate dehydrogenase; Provisional; Region: PRK05442 1260251005071 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1260251005072 NAD(P) binding site [chemical binding]; other site 1260251005073 dimer interface [polypeptide binding]; other site 1260251005074 malate binding site [chemical binding]; other site 1260251005075 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1260251005076 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1260251005077 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1260251005078 alphaNTD homodimer interface [polypeptide binding]; other site 1260251005079 alphaNTD - beta interaction site [polypeptide binding]; other site 1260251005080 alphaNTD - beta' interaction site [polypeptide binding]; other site 1260251005081 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1260251005082 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1260251005083 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1260251005084 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1260251005085 RNA binding surface [nucleotide binding]; other site 1260251005086 30S ribosomal protein S11; Validated; Region: PRK05309 1260251005087 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1260251005088 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1260251005089 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1260251005090 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1260251005091 SecY translocase; Region: SecY; pfam00344 1260251005092 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1260251005093 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1260251005094 23S rRNA binding site [nucleotide binding]; other site 1260251005095 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1260251005096 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1260251005097 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1260251005098 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1260251005099 5S rRNA interface [nucleotide binding]; other site 1260251005100 23S rRNA interface [nucleotide binding]; other site 1260251005101 L5 interface [polypeptide binding]; other site 1260251005102 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1260251005103 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1260251005104 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1260251005105 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1260251005106 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1260251005107 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1260251005108 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1260251005109 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1260251005110 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1260251005111 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1260251005112 RNA binding site [nucleotide binding]; other site 1260251005113 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1260251005114 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1260251005115 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1260251005116 putative translocon interaction site; other site 1260251005117 signal recognition particle (SRP54) interaction site; other site 1260251005118 L23 interface [polypeptide binding]; other site 1260251005119 trigger factor interaction site; other site 1260251005120 23S rRNA interface [nucleotide binding]; other site 1260251005121 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1260251005122 23S rRNA interface [nucleotide binding]; other site 1260251005123 5S rRNA interface [nucleotide binding]; other site 1260251005124 putative antibiotic binding site [chemical binding]; other site 1260251005125 L25 interface [polypeptide binding]; other site 1260251005126 L27 interface [polypeptide binding]; other site 1260251005127 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1260251005128 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1260251005129 G-X-X-G motif; other site 1260251005130 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1260251005131 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1260251005132 protein-rRNA interface [nucleotide binding]; other site 1260251005133 putative translocon binding site; other site 1260251005134 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1260251005135 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1260251005136 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1260251005137 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1260251005138 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1260251005139 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1260251005140 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1260251005141 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1260251005142 elongation factor Tu; Reviewed; Region: PRK00049 1260251005143 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1260251005144 G1 box; other site 1260251005145 GEF interaction site [polypeptide binding]; other site 1260251005146 GTP/Mg2+ binding site [chemical binding]; other site 1260251005147 Switch I region; other site 1260251005148 G2 box; other site 1260251005149 G3 box; other site 1260251005150 Switch II region; other site 1260251005151 G4 box; other site 1260251005152 G5 box; other site 1260251005153 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1260251005154 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1260251005155 Antibiotic Binding Site [chemical binding]; other site 1260251005156 elongation factor G; Reviewed; Region: PRK00007 1260251005157 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1260251005158 G1 box; other site 1260251005159 putative GEF interaction site [polypeptide binding]; other site 1260251005160 GTP/Mg2+ binding site [chemical binding]; other site 1260251005161 Switch I region; other site 1260251005162 G2 box; other site 1260251005163 G3 box; other site 1260251005164 Switch II region; other site 1260251005165 G4 box; other site 1260251005166 G5 box; other site 1260251005167 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1260251005168 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1260251005169 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1260251005170 30S ribosomal protein S7; Validated; Region: PRK05302 1260251005171 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1260251005172 S17 interaction site [polypeptide binding]; other site 1260251005173 S8 interaction site; other site 1260251005174 16S rRNA interaction site [nucleotide binding]; other site 1260251005175 streptomycin interaction site [chemical binding]; other site 1260251005176 23S rRNA interaction site [nucleotide binding]; other site 1260251005177 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1260251005178 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1260251005179 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1260251005180 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1260251005181 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1260251005182 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1260251005183 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1260251005184 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1260251005185 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1260251005186 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1260251005187 DNA binding site [nucleotide binding] 1260251005188 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1260251005189 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1260251005190 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1260251005191 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1260251005192 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1260251005193 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1260251005194 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1260251005195 RPB3 interaction site [polypeptide binding]; other site 1260251005196 RPB1 interaction site [polypeptide binding]; other site 1260251005197 RPB11 interaction site [polypeptide binding]; other site 1260251005198 RPB10 interaction site [polypeptide binding]; other site 1260251005199 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1260251005200 peripheral dimer interface [polypeptide binding]; other site 1260251005201 core dimer interface [polypeptide binding]; other site 1260251005202 L10 interface [polypeptide binding]; other site 1260251005203 L11 interface [polypeptide binding]; other site 1260251005204 putative EF-Tu interaction site [polypeptide binding]; other site 1260251005205 putative EF-G interaction site [polypeptide binding]; other site 1260251005206 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1260251005207 23S rRNA interface [nucleotide binding]; other site 1260251005208 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1260251005209 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1260251005210 mRNA/rRNA interface [nucleotide binding]; other site 1260251005211 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1260251005212 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1260251005213 23S rRNA interface [nucleotide binding]; other site 1260251005214 L7/L12 interface [polypeptide binding]; other site 1260251005215 putative thiostrepton binding site; other site 1260251005216 L25 interface [polypeptide binding]; other site 1260251005217 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1260251005218 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1260251005219 putative homodimer interface [polypeptide binding]; other site 1260251005220 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1260251005221 heterodimer interface [polypeptide binding]; other site 1260251005222 homodimer interface [polypeptide binding]; other site 1260251005223 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1260251005224 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1260251005225 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1260251005226 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1260251005227 Antibiotic Binding Site [chemical binding]; other site 1260251005228 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1260251005229 G1 box; other site 1260251005230 GTP/Mg2+ binding site [chemical binding]; other site 1260251005231 G2 box; other site 1260251005232 Switch I region; other site 1260251005233 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1260251005234 active site 1260251005235 Calx-beta domain; Region: Calx-beta; pfam03160 1260251005236 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1260251005237 active site 1260251005238 DNA binding site [nucleotide binding] 1260251005239 Int/Topo IB signature motif; other site 1260251005240 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1260251005241 active site 1260251005242 DNA binding site [nucleotide binding] 1260251005243 Int/Topo IB signature motif; other site 1260251005244 Integrase core domain; Region: rve; pfam00665 1260251005245 Integrase core domain; Region: rve_3; pfam13683 1260251005246 Calx-beta domain; Region: Calx-beta; cl02522 1260251005247 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1260251005248 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1260251005249 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1260251005250 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1260251005251 active site 1260251005252 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1260251005253 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1260251005254 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1260251005255 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1260251005256 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1260251005257 coenzyme F420-reducing hydrogenase subunit beta; Validated; Region: PRK09325 1260251005258 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 1260251005259 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1260251005260 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1260251005261 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1260251005262 putative ADP-binding pocket [chemical binding]; other site 1260251005263 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1260251005264 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1260251005265 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1260251005266 HlyD family secretion protein; Region: HlyD_3; pfam13437 1260251005267 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1260251005268 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1260251005269 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1260251005270 Walker A/P-loop; other site 1260251005271 ATP binding site [chemical binding]; other site 1260251005272 Q-loop/lid; other site 1260251005273 ABC transporter signature motif; other site 1260251005274 Walker B; other site 1260251005275 D-loop; other site 1260251005276 H-loop/switch region; other site 1260251005277 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1260251005278 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1260251005279 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1260251005280 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1260251005281 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1260251005282 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1260251005283 active site 1260251005284 HIGH motif; other site 1260251005285 dimer interface [polypeptide binding]; other site 1260251005286 KMSKS motif; other site 1260251005287 S4 RNA-binding domain; Region: S4; smart00363 1260251005288 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1260251005289 Peptidase family M23; Region: Peptidase_M23; pfam01551 1260251005290 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1260251005291 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1260251005292 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1260251005293 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1260251005294 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1260251005295 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1260251005296 Cl- selectivity filter; other site 1260251005297 Cl- binding residues [ion binding]; other site 1260251005298 pore gating glutamate residue; other site 1260251005299 dimer interface [polypeptide binding]; other site 1260251005300 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1260251005301 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1260251005302 catalytic residues [active] 1260251005303 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1260251005304 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1260251005305 metal binding site 2 [ion binding]; metal-binding site 1260251005306 putative DNA binding helix; other site 1260251005307 metal binding site 1 [ion binding]; metal-binding site 1260251005308 structural Zn2+ binding site [ion binding]; other site 1260251005309 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 1260251005310 GAF domain; Region: GAF; pfam01590 1260251005311 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1260251005312 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1260251005313 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1260251005314 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1260251005315 putative active site [active] 1260251005316 Ap4A binding site [chemical binding]; other site 1260251005317 nudix motif; other site 1260251005318 putative metal binding site [ion binding]; other site 1260251005319 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1260251005320 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1260251005321 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1260251005322 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1260251005323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1260251005324 FeS/SAM binding site; other site 1260251005325 HemN C-terminal domain; Region: HemN_C; pfam06969 1260251005326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1260251005327 Predicted membrane protein [Function unknown]; Region: COG3686 1260251005328 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1260251005329 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1260251005330 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1260251005331 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1260251005332 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1260251005333 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1260251005334 purine monophosphate binding site [chemical binding]; other site 1260251005335 dimer interface [polypeptide binding]; other site 1260251005336 putative catalytic residues [active] 1260251005337 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1260251005338 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1260251005339 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1260251005340 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1260251005341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1260251005342 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1260251005343 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1260251005344 dimer interface [polypeptide binding]; other site 1260251005345 substrate binding site [chemical binding]; other site 1260251005346 metal binding sites [ion binding]; metal-binding site 1260251005347 6-phosphofructokinase; Provisional; Region: PRK14072 1260251005348 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1260251005349 active site 1260251005350 ADP/pyrophosphate binding site [chemical binding]; other site 1260251005351 dimerization interface [polypeptide binding]; other site 1260251005352 allosteric effector site; other site 1260251005353 fructose-1,6-bisphosphate binding site; other site 1260251005354 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1260251005355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1260251005356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1260251005357 S-adenosylmethionine binding site [chemical binding]; other site 1260251005358 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1260251005359 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1260251005360 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1260251005361 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1260251005362 aromatic acid decarboxylase; Validated; Region: PRK05920 1260251005363 Flavoprotein; Region: Flavoprotein; pfam02441 1260251005364 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1260251005365 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1260251005366 LssY C-terminus; Region: LssY_C; pfam14067 1260251005367 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1260251005368 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1260251005369 inhibitor-cofactor binding pocket; inhibition site 1260251005370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251005371 catalytic residue [active] 1260251005372 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1260251005373 thiamine phosphate binding site [chemical binding]; other site 1260251005374 active site 1260251005375 pyrophosphate binding site [ion binding]; other site 1260251005376 Rubredoxin [Energy production and conversion]; Region: COG1773 1260251005377 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1260251005378 iron binding site [ion binding]; other site 1260251005379 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1260251005380 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1260251005381 active site 1260251005382 metal binding site [ion binding]; metal-binding site 1260251005383 hexamer interface [polypeptide binding]; other site 1260251005384 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 1260251005385 putative active site [active] 1260251005386 putative metal binding site [ion binding]; other site 1260251005387 YfaZ precursor; Region: YfaZ; pfam07437 1260251005388 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1260251005389 FAD binding domain; Region: FAD_binding_4; pfam01565 1260251005390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1260251005391 MOSC domain; Region: MOSC; pfam03473 1260251005392 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1260251005393 FAD binding site [chemical binding]; other site 1260251005394 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1260251005395 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1260251005396 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1260251005397 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1260251005398 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1260251005399 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1260251005400 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1260251005401 active site 1260251005402 homotetramer interface [polypeptide binding]; other site 1260251005403 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1260251005404 active site 1260251005405 DNA polymerase IV; Validated; Region: PRK02406 1260251005406 DNA binding site [nucleotide binding] 1260251005407 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1260251005408 CoA binding domain; Region: CoA_binding_2; pfam13380 1260251005409 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1260251005410 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1260251005411 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1260251005412 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1260251005413 Coenzyme A binding pocket [chemical binding]; other site 1260251005414 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 1260251005415 putative homodimer interface [polypeptide binding]; other site 1260251005416 putative homotetramer interface [polypeptide binding]; other site 1260251005417 allosteric switch controlling residues; other site 1260251005418 putative metal binding site [ion binding]; other site 1260251005419 putative homodimer-homodimer interface [polypeptide binding]; other site 1260251005420 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1260251005421 metal-binding site [ion binding] 1260251005422 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1260251005423 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1260251005424 metal-binding site [ion binding] 1260251005425 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1260251005426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1260251005427 motif II; other site 1260251005428 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1260251005429 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1260251005430 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 1260251005431 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1260251005432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1260251005433 dimer interface [polypeptide binding]; other site 1260251005434 conserved gate region; other site 1260251005435 putative PBP binding loops; other site 1260251005436 ABC-ATPase subunit interface; other site 1260251005437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1260251005438 dimer interface [polypeptide binding]; other site 1260251005439 conserved gate region; other site 1260251005440 putative PBP binding loops; other site 1260251005441 ABC-ATPase subunit interface; other site 1260251005442 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1260251005443 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1260251005444 Walker A/P-loop; other site 1260251005445 ATP binding site [chemical binding]; other site 1260251005446 Q-loop/lid; other site 1260251005447 ABC transporter signature motif; other site 1260251005448 Walker B; other site 1260251005449 D-loop; other site 1260251005450 H-loop/switch region; other site 1260251005451 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1260251005452 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1260251005453 Walker A/P-loop; other site 1260251005454 ATP binding site [chemical binding]; other site 1260251005455 Q-loop/lid; other site 1260251005456 ABC transporter signature motif; other site 1260251005457 Walker B; other site 1260251005458 D-loop; other site 1260251005459 H-loop/switch region; other site 1260251005460 TOBE domain; Region: TOBE_2; pfam08402 1260251005461 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1260251005462 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1260251005463 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1260251005464 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1260251005465 glycerol kinase; Provisional; Region: glpK; PRK00047 1260251005466 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1260251005467 N- and C-terminal domain interface [polypeptide binding]; other site 1260251005468 active site 1260251005469 MgATP binding site [chemical binding]; other site 1260251005470 catalytic site [active] 1260251005471 metal binding site [ion binding]; metal-binding site 1260251005472 glycerol binding site [chemical binding]; other site 1260251005473 homotetramer interface [polypeptide binding]; other site 1260251005474 homodimer interface [polypeptide binding]; other site 1260251005475 FBP binding site [chemical binding]; other site 1260251005476 protein IIAGlc interface [polypeptide binding]; other site 1260251005477 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1260251005478 dimer interface [polypeptide binding]; other site 1260251005479 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1260251005480 active site 1260251005481 metal binding site [ion binding]; metal-binding site 1260251005482 glutathione binding site [chemical binding]; other site 1260251005483 TspO/MBR family; Region: TspO_MBR; pfam03073 1260251005484 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1260251005485 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1260251005486 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1260251005487 putative effector binding pocket; other site 1260251005488 dimerization interface [polypeptide binding]; other site 1260251005489 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1260251005490 AzlC protein; Region: AzlC; pfam03591 1260251005491 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1260251005492 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1260251005493 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1260251005494 dimer interface [polypeptide binding]; other site 1260251005495 N-terminal domain interface [polypeptide binding]; other site 1260251005496 substrate binding pocket (H-site) [chemical binding]; other site 1260251005497 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1260251005498 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1260251005499 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1260251005500 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1260251005501 E3 interaction surface; other site 1260251005502 lipoyl attachment site [posttranslational modification]; other site 1260251005503 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1260251005504 dimerization interface [polypeptide binding]; other site 1260251005505 active site 1260251005506 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1260251005507 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1260251005508 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1260251005509 putative dimer interface [polypeptide binding]; other site 1260251005510 N-terminal domain interface [polypeptide binding]; other site 1260251005511 putative substrate binding pocket (H-site) [chemical binding]; other site 1260251005512 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1260251005513 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1260251005514 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1260251005515 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1260251005516 putative ADP-binding pocket [chemical binding]; other site 1260251005517 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1260251005518 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1260251005519 homodecamer interface [polypeptide binding]; other site 1260251005520 GTP cyclohydrolase I; Provisional; Region: PLN03044 1260251005521 active site 1260251005522 putative catalytic site residues [active] 1260251005523 zinc binding site [ion binding]; other site 1260251005524 GTP-CH-I/GFRP interaction surface; other site 1260251005525 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1260251005526 homooctamer interface [polypeptide binding]; other site 1260251005527 active site 1260251005528 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1260251005529 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1260251005530 Ligand Binding Site [chemical binding]; other site 1260251005531 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1260251005532 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1260251005533 HlyD family secretion protein; Region: HlyD_3; pfam13437 1260251005534 multidrug efflux protein; Reviewed; Region: PRK09579 1260251005535 nodulation ABC transporter NodI; Provisional; Region: PRK13537 1260251005536 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1260251005537 Walker A/P-loop; other site 1260251005538 ATP binding site [chemical binding]; other site 1260251005539 Q-loop/lid; other site 1260251005540 ABC transporter signature motif; other site 1260251005541 Walker B; other site 1260251005542 D-loop; other site 1260251005543 H-loop/switch region; other site 1260251005544 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1260251005545 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1260251005546 active site 1260251005547 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1260251005548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1260251005549 DNA-binding site [nucleotide binding]; DNA binding site 1260251005550 FCD domain; Region: FCD; pfam07729 1260251005551 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 1260251005552 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1260251005553 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1260251005554 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1260251005555 tetrameric interface [polypeptide binding]; other site 1260251005556 NAD binding site [chemical binding]; other site 1260251005557 catalytic residues [active] 1260251005558 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1260251005559 sequence-specific DNA binding site [nucleotide binding]; other site 1260251005560 salt bridge; other site 1260251005561 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1260251005562 threonine dehydratase; Reviewed; Region: PRK09224 1260251005563 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1260251005564 tetramer interface [polypeptide binding]; other site 1260251005565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251005566 catalytic residue [active] 1260251005567 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1260251005568 putative Ile/Val binding site [chemical binding]; other site 1260251005569 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1260251005570 putative Ile/Val binding site [chemical binding]; other site 1260251005571 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1260251005572 active site 1260251005573 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1260251005574 dimer interface [polypeptide binding]; other site 1260251005575 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1260251005576 catalytic residues [active] 1260251005577 dimer interface [polypeptide binding]; other site 1260251005578 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1260251005579 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 1260251005580 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1260251005581 homodimer interface [polypeptide binding]; other site 1260251005582 substrate-cofactor binding pocket; other site 1260251005583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1260251005584 catalytic residue [active] 1260251005585 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1260251005586 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1260251005587 NAD binding site [chemical binding]; other site 1260251005588 homodimer interface [polypeptide binding]; other site 1260251005589 active site 1260251005590 substrate binding site [chemical binding]; other site 1260251005591 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1260251005592 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1260251005593 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1260251005594 NAD(P) binding site [chemical binding]; other site 1260251005595 homodimer interface [polypeptide binding]; other site 1260251005596 substrate binding site [chemical binding]; other site 1260251005597 active site 1260251005598 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1260251005599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1260251005600 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1260251005601 NAD(P) binding site [chemical binding]; other site 1260251005602 active site 1260251005603 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1260251005604 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1260251005605 putative NAD(P) binding site [chemical binding]; other site 1260251005606 active site 1260251005607 putative substrate binding site [chemical binding]; other site 1260251005608 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1260251005609 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1260251005610 active site 1260251005611 substrate binding site [chemical binding]; other site 1260251005612 metal binding site [ion binding]; metal-binding site 1260251005613 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1260251005614 dimer interface [polypeptide binding]; other site 1260251005615 catalytic triad [active] 1260251005616 peroxidatic and resolving cysteines [active] 1260251005617 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1260251005618 lipoyl attachment site [posttranslational modification]; other site 1260251005619 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1260251005620 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1260251005621 proline aminopeptidase P II; Provisional; Region: PRK10879 1260251005622 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1260251005623 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1260251005624 active site 1260251005625 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 1260251005626 TIGR02449 family protein; Region: TIGR02449 1260251005627 Cell division protein ZapA; Region: ZapA; pfam05164 1260251005628 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1260251005629 EVE domain; Region: EVE; cl00728 1260251005630 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1260251005631 N-acetylglutamate synthase; Validated; Region: PRK05279 1260251005632 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1260251005633 putative feedback inhibition sensing region; other site 1260251005634 putative nucleotide binding site [chemical binding]; other site 1260251005635 putative substrate binding site [chemical binding]; other site 1260251005636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1260251005637 Coenzyme A binding pocket [chemical binding]; other site 1260251005638 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1260251005639 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1260251005640 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1260251005641 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1260251005642 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1260251005643 dimerization interface [polypeptide binding]; other site 1260251005644 active site 1260251005645 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1260251005646 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1260251005647 folate binding site [chemical binding]; other site 1260251005648 NADP+ binding site [chemical binding]; other site 1260251005649 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1260251005650 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1260251005651 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1260251005652 RNA binding site [nucleotide binding]; other site 1260251005653 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1260251005654 multimer interface [polypeptide binding]; other site 1260251005655 Walker A motif; other site 1260251005656 ATP binding site [chemical binding]; other site 1260251005657 Walker B motif; other site 1260251005658 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1260251005659 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1260251005660 catalytic residues [active] 1260251005661 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1260251005662 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1260251005663 active site 1260251005664 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 1260251005665 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1260251005666 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1260251005667 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1260251005668 FtsX-like permease family; Region: FtsX; pfam02687 1260251005669 FtsX-like permease family; Region: FtsX; pfam02687 1260251005670 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1260251005671 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1260251005672 Walker A/P-loop; other site 1260251005673 ATP binding site [chemical binding]; other site 1260251005674 Q-loop/lid; other site 1260251005675 ABC transporter signature motif; other site 1260251005676 Walker B; other site 1260251005677 D-loop; other site 1260251005678 H-loop/switch region; other site 1260251005679 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1260251005680 active site 1260251005681 catalytic triad [active] 1260251005682 oxyanion hole [active] 1260251005683 switch loop; other site 1260251005684 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1260251005685 putative catalytic site [active] 1260251005686 putative metal binding site [ion binding]; other site 1260251005687 putative phosphate binding site [ion binding]; other site 1260251005688 putative catalytic site [active] 1260251005689 putative phosphate binding site [ion binding]; other site 1260251005690 putative metal binding site [ion binding]; other site 1260251005691 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1260251005692 catalytic residues [active] 1260251005693 hinge region; other site 1260251005694 alpha helical domain; other site 1260251005695 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1260251005696 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1260251005697 ResB-like family; Region: ResB; pfam05140 1260251005698 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1260251005699 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1260251005700 Cytochrome c; Region: Cytochrom_C; cl11414 1260251005701 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1260251005702 G1 box; other site 1260251005703 GTP/Mg2+ binding site [chemical binding]; other site 1260251005704 Switch I region; other site 1260251005705 G2 box; other site 1260251005706 G3 box; other site 1260251005707 Switch II region; other site 1260251005708 G4 box; other site 1260251005709 G5 box; other site 1260251005710 DNA polymerase I; Provisional; Region: PRK05755 1260251005711 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1260251005712 active site 1260251005713 metal binding site 1 [ion binding]; metal-binding site 1260251005714 putative 5' ssDNA interaction site; other site 1260251005715 metal binding site 3; metal-binding site 1260251005716 metal binding site 2 [ion binding]; metal-binding site 1260251005717 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1260251005718 putative DNA binding site [nucleotide binding]; other site 1260251005719 putative metal binding site [ion binding]; other site 1260251005720 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1260251005721 active site 1260251005722 catalytic site [active] 1260251005723 substrate binding site [chemical binding]; other site 1260251005724 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1260251005725 active site 1260251005726 DNA binding site [nucleotide binding] 1260251005727 catalytic site [active] 1260251005728 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1260251005729 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1260251005730 Part of AAA domain; Region: AAA_19; pfam13245 1260251005731 Family description; Region: UvrD_C_2; pfam13538 1260251005732 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1260251005733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1260251005734 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1260251005735 dimerization interface [polypeptide binding]; other site 1260251005736 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 1260251005737 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1260251005738 metal binding site [ion binding]; metal-binding site 1260251005739 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1260251005740 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1260251005741 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1260251005742 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1260251005743 dimer interface [polypeptide binding]; other site 1260251005744 ABC-ATPase subunit interface; other site 1260251005745 PAS domain; Region: PAS_9; pfam13426 1260251005746 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1260251005747 putative active site [active] 1260251005748 heme pocket [chemical binding]; other site 1260251005749 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1260251005750 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1260251005751 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1260251005752 catalytic residue [active] 1260251005753 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1260251005754 Transposase IS200 like; Region: Y1_Tnp; cl00848 1260251005755 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1260251005756 hydrophobic ligand binding site; other site 1260251005757 PAS domain; Region: PAS_9; pfam13426 1260251005758 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1260251005759 putative active site [active] 1260251005760 heme pocket [chemical binding]; other site 1260251005761 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1260251005762 classical (c) SDRs; Region: SDR_c; cd05233 1260251005763 NAD(P) binding site [chemical binding]; other site 1260251005764 active site 1260251005765 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1260251005766 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1260251005767 glutaminase active site [active] 1260251005768 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1260251005769 dimer interface [polypeptide binding]; other site 1260251005770 active site 1260251005771 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1260251005772 dimer interface [polypeptide binding]; other site 1260251005773 active site 1260251005774 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 1260251005775 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1260251005776 Substrate binding site; other site 1260251005777 Mg++ binding site; other site 1260251005778 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1260251005779 active site 1260251005780 substrate binding site [chemical binding]; other site 1260251005781 CoA binding site [chemical binding]; other site 1260251005782 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1260251005783 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1260251005784 gamma subunit interface [polypeptide binding]; other site 1260251005785 epsilon subunit interface [polypeptide binding]; other site 1260251005786 LBP interface [polypeptide binding]; other site 1260251005787 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1260251005788 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1260251005789 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1260251005790 alpha subunit interaction interface [polypeptide binding]; other site 1260251005791 Walker A motif; other site 1260251005792 ATP binding site [chemical binding]; other site 1260251005793 Walker B motif; other site 1260251005794 inhibitor binding site; inhibition site 1260251005795 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1260251005796 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1260251005797 core domain interface [polypeptide binding]; other site 1260251005798 delta subunit interface [polypeptide binding]; other site 1260251005799 epsilon subunit interface [polypeptide binding]; other site 1260251005800 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1260251005801 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1260251005802 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1260251005803 beta subunit interaction interface [polypeptide binding]; other site 1260251005804 Walker A motif; other site 1260251005805 ATP binding site [chemical binding]; other site 1260251005806 Walker B motif; other site 1260251005807 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1260251005808 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1260251005809 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1260251005810 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1260251005811 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1260251005812 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1260251005813 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1260251005814 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1260251005815 ATP synthase I chain; Region: ATP_synt_I; cl09170 1260251005816 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1260251005817 ParB-like nuclease domain; Region: ParB; smart00470 1260251005818 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1260251005819 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1260251005820 P-loop; other site 1260251005821 Magnesium ion binding site [ion binding]; other site 1260251005822 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1260251005823 Magnesium ion binding site [ion binding]; other site 1260251005824 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1260251005825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1260251005826 S-adenosylmethionine binding site [chemical binding]; other site 1260251005827 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1260251005828 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1260251005829 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1260251005830 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1260251005831 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1260251005832 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1260251005833 G1 box; other site 1260251005834 GTP/Mg2+ binding site [chemical binding]; other site 1260251005835 Switch I region; other site 1260251005836 G2 box; other site 1260251005837 Switch II region; other site 1260251005838 G3 box; other site 1260251005839 G4 box; other site 1260251005840 G5 box; other site 1260251005841 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1260251005842 membrane protein insertase; Provisional; Region: PRK01318 1260251005843 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1260251005844 Haemolytic domain; Region: Haemolytic; pfam01809 1260251005845 Ribonuclease P; Region: Ribonuclease_P; cl00457 1260251005846 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399