-- dump date   	20140619_070112
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
498217000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
498217000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
498217000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217000004	Walker A motif; other site
498217000005	ATP binding site [chemical binding]; other site
498217000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
498217000007	Walker B motif; other site
498217000008	arginine finger; other site
498217000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
498217000010	DnaA box-binding interface [nucleotide binding]; other site
498217000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
498217000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
498217000013	putative DNA binding surface [nucleotide binding]; other site
498217000014	dimer interface [polypeptide binding]; other site
498217000015	beta-clamp/clamp loader binding surface; other site
498217000016	beta-clamp/translesion DNA polymerase binding surface; other site
498217000017	recombination protein F; Reviewed; Region: recF; PRK00064
498217000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217000019	Walker A/P-loop; other site
498217000020	ATP binding site [chemical binding]; other site
498217000021	Q-loop/lid; other site
498217000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217000023	ABC transporter signature motif; other site
498217000024	Walker B; other site
498217000025	D-loop; other site
498217000026	H-loop/switch region; other site
498217000027	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
498217000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217000029	ATP binding site [chemical binding]; other site
498217000030	Mg2+ binding site [ion binding]; other site
498217000031	G-X-G motif; other site
498217000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
498217000033	anchoring element; other site
498217000034	dimer interface [polypeptide binding]; other site
498217000035	ATP binding site [chemical binding]; other site
498217000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
498217000037	active site
498217000038	putative metal-binding site [ion binding]; other site
498217000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
498217000040	sugar phosphate phosphatase; Provisional; Region: PRK10513
498217000041	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217000042	active site
498217000043	motif I; other site
498217000044	motif II; other site
498217000045	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217000046	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
498217000047	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
498217000048	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
498217000049	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
498217000050	putative dimer interface [polypeptide binding]; other site
498217000051	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
498217000052	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
498217000053	putative dimer interface [polypeptide binding]; other site
498217000054	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
498217000055	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498217000056	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217000057	homodimer interface [polypeptide binding]; other site
498217000058	catalytic residue [active]
498217000059	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
498217000060	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
498217000061	DALR anticodon binding domain; Region: DALR_1; pfam05746
498217000062	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
498217000063	dimer interface [polypeptide binding]; other site
498217000064	motif 1; other site
498217000065	active site
498217000066	motif 2; other site
498217000067	motif 3; other site
498217000068	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
498217000069	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
498217000070	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498217000071	Coenzyme A binding pocket [chemical binding]; other site
498217000072	Predicted membrane protein [Function unknown]; Region: COG2119
498217000073	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
498217000074	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
498217000075	putative outer membrane lipoprotein; Provisional; Region: PRK10510
498217000076	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
498217000077	ligand binding site [chemical binding]; other site
498217000078	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
498217000079	CPxP  motif; other site
498217000080	hypothetical protein; Provisional; Region: PRK11212
498217000081	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
498217000082	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
498217000083	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498217000084	Coenzyme A binding pocket [chemical binding]; other site
498217000085	hypothetical protein; Provisional; Region: PRK11615
498217000086	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
498217000087	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
498217000088	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
498217000089	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
498217000090	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
498217000091	generic binding surface II; other site
498217000092	ssDNA binding site; other site
498217000093	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498217000094	ATP binding site [chemical binding]; other site
498217000095	putative Mg++ binding site [ion binding]; other site
498217000096	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498217000097	nucleotide binding region [chemical binding]; other site
498217000098	ATP-binding site [chemical binding]; other site
498217000099	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
498217000100	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
498217000101	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
498217000102	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
498217000103	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
498217000104	Zn2+ binding site [ion binding]; other site
498217000105	Mg2+ binding site [ion binding]; other site
498217000106	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
498217000107	synthetase active site [active]
498217000108	NTP binding site [chemical binding]; other site
498217000109	metal binding site [ion binding]; metal-binding site
498217000110	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
498217000111	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
498217000112	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
498217000113	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
498217000114	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
498217000115	catalytic site [active]
498217000116	G-X2-G-X-G-K; other site
498217000117	Predicted membrane protein [Function unknown]; Region: COG2860
498217000118	UPF0126 domain; Region: UPF0126; pfam03458
498217000119	UPF0126 domain; Region: UPF0126; pfam03458
498217000120	Domain of unknown function (DUF955); Region: DUF955; cl01076
498217000121	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
498217000122	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498217000123	ATP binding site [chemical binding]; other site
498217000124	putative Mg++ binding site [ion binding]; other site
498217000125	nucleotide binding region [chemical binding]; other site
498217000126	helicase superfamily c-terminal domain; Region: HELICc; smart00490
498217000127	ATP-binding site [chemical binding]; other site
498217000128	transposase/IS protein; Provisional; Region: PRK09183
498217000129	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217000130	Walker A motif; other site
498217000131	ATP binding site [chemical binding]; other site
498217000132	Walker B motif; other site
498217000133	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
498217000134	Helix-turn-helix domain; Region: HTH_38; pfam13936
498217000135	Integrase core domain; Region: rve; pfam00665
498217000136	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
498217000137	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
498217000138	active site
498217000139	catalytic residues [active]
498217000140	DNA binding site [nucleotide binding]
498217000141	Int/Topo IB signature motif; other site
498217000142	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
498217000143	MPN+ (JAMM) motif; other site
498217000144	Zinc-binding site [ion binding]; other site
498217000145	Protein of unknown function (DUF2787); Region: DUF2787; pfam10980
498217000146	Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423
498217000147	N-glycosyltransferase; Provisional; Region: PRK11204
498217000148	integrase; Provisional; Region: PRK09692
498217000149	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
498217000150	active site
498217000151	Int/Topo IB signature motif; other site
498217000152	hypothetical protein; Provisional; Region: PRK11820
498217000153	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
498217000154	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
498217000155	ribonuclease PH; Reviewed; Region: rph; PRK00173
498217000156	Ribonuclease PH; Region: RNase_PH_bact; cd11362
498217000157	hexamer interface [polypeptide binding]; other site
498217000158	active site
498217000159	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498217000160	active site
498217000161	division inhibitor protein; Provisional; Region: slmA; PRK09480
498217000162	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498217000163	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
498217000164	trimer interface [polypeptide binding]; other site
498217000165	active site
498217000166	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
498217000167	Flavoprotein; Region: Flavoprotein; pfam02441
498217000168	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
498217000169	hypothetical protein; Reviewed; Region: PRK00024
498217000170	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
498217000171	MPN+ (JAMM) motif; other site
498217000172	Zinc-binding site [ion binding]; other site
498217000173	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
498217000174	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
498217000175	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
498217000176	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
498217000177	DNA binding site [nucleotide binding]
498217000178	catalytic residue [active]
498217000179	H2TH interface [polypeptide binding]; other site
498217000180	putative catalytic residues [active]
498217000181	turnover-facilitating residue; other site
498217000182	intercalation triad [nucleotide binding]; other site
498217000183	8OG recognition residue [nucleotide binding]; other site
498217000184	putative reading head residues; other site
498217000185	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
498217000186	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
498217000187	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
498217000188	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
498217000189	active site
498217000190	(T/H)XGH motif; other site
498217000191	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
498217000192	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
498217000193	putative metal binding site; other site
498217000194	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
498217000195	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
498217000196	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
498217000197	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498217000198	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
498217000199	putative ADP-binding pocket [chemical binding]; other site
498217000200	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
498217000201	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
498217000202	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422
498217000203	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
498217000204	putative active site [active]
498217000205	Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935
498217000206	putative active site [active]
498217000207	putative catalytic site [active]
498217000208	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
498217000209	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498217000210	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498217000211	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
498217000212	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498217000213	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
498217000214	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
498217000215	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
498217000216	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
498217000217	putative active site [active]
498217000218	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
498217000219	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
498217000220	putative active site [active]
498217000221	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
498217000222	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
498217000223	NADP binding site [chemical binding]; other site
498217000224	homopentamer interface [polypeptide binding]; other site
498217000225	substrate binding site [chemical binding]; other site
498217000226	active site
498217000227	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
498217000228	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
498217000229	substrate-cofactor binding pocket; other site
498217000230	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217000231	catalytic residue [active]
498217000232	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
498217000233	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
498217000234	NAD(P) binding site [chemical binding]; other site
498217000235	putative ATP-dependent protease; Provisional; Region: PRK09862
498217000236	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
498217000237	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217000238	Walker A motif; other site
498217000239	ATP binding site [chemical binding]; other site
498217000240	Walker B motif; other site
498217000241	arginine finger; other site
498217000242	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
498217000243	putative sialic acid transporter; Region: 2A0112; TIGR00891
498217000244	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217000245	putative substrate translocation pore; other site
498217000246	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
498217000247	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
498217000248	PYR/PP interface [polypeptide binding]; other site
498217000249	dimer interface [polypeptide binding]; other site
498217000250	TPP binding site [chemical binding]; other site
498217000251	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
498217000252	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
498217000253	TPP-binding site [chemical binding]; other site
498217000254	dimer interface [polypeptide binding]; other site
498217000255	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
498217000256	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
498217000257	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
498217000258	homodimer interface [polypeptide binding]; other site
498217000259	substrate-cofactor binding pocket; other site
498217000260	catalytic residue [active]
498217000261	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
498217000262	threonine dehydratase; Reviewed; Region: PRK09224
498217000263	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
498217000264	tetramer interface [polypeptide binding]; other site
498217000265	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217000266	catalytic residue [active]
498217000267	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
498217000268	putative Ile/Val binding site [chemical binding]; other site
498217000269	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
498217000270	putative Ile/Val binding site [chemical binding]; other site
498217000271	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217000272	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
498217000273	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
498217000274	dimerization interface [polypeptide binding]; other site
498217000275	ketol-acid reductoisomerase; Validated; Region: PRK05225
498217000276	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
498217000277	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
498217000278	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
498217000279	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
498217000280	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
498217000281	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
498217000282	Part of AAA domain; Region: AAA_19; pfam13245
498217000283	Family description; Region: UvrD_C_2; pfam13538
498217000284	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
498217000285	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
498217000286	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
498217000287	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
498217000288	ATP binding site [chemical binding]; other site
498217000289	Mg++ binding site [ion binding]; other site
498217000290	motif III; other site
498217000291	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498217000292	nucleotide binding region [chemical binding]; other site
498217000293	ATP-binding site [chemical binding]; other site
498217000294	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
498217000295	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
498217000296	catalytic residues [active]
498217000297	transcription termination factor Rho; Provisional; Region: rho; PRK09376
498217000298	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
498217000299	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
498217000300	RNA binding site [nucleotide binding]; other site
498217000301	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
498217000302	multimer interface [polypeptide binding]; other site
498217000303	Walker A motif; other site
498217000304	ATP binding site [chemical binding]; other site
498217000305	Walker B motif; other site
498217000306	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
498217000307	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
498217000308	Mg++ binding site [ion binding]; other site
498217000309	putative catalytic motif [active]
498217000310	substrate binding site [chemical binding]; other site
498217000311	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
498217000312	Chain length determinant protein; Region: Wzz; cl15801
498217000313	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
498217000314	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
498217000315	active site
498217000316	homodimer interface [polypeptide binding]; other site
498217000317	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
498217000318	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
498217000319	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
498217000320	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
498217000321	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
498217000322	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
498217000323	NAD binding site [chemical binding]; other site
498217000324	substrate binding site [chemical binding]; other site
498217000325	homodimer interface [polypeptide binding]; other site
498217000326	active site
498217000327	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
498217000328	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
498217000329	substrate binding site; other site
498217000330	tetramer interface; other site
498217000331	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498217000332	Coenzyme A binding pocket [chemical binding]; other site
498217000333	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
498217000334	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
498217000335	inhibitor-cofactor binding pocket; inhibition site
498217000336	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217000337	catalytic residue [active]
498217000338	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
498217000339	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929
498217000340	putative common antigen polymerase; Provisional; Region: PRK02975
498217000341	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
498217000342	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
498217000343	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
498217000344	HemY protein N-terminus; Region: HemY_N; pfam07219
498217000345	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
498217000346	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
498217000347	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
498217000348	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
498217000349	active site
498217000350	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
498217000351	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
498217000352	domain interfaces; other site
498217000353	active site
498217000354	adenylate cyclase; Provisional; Region: cyaA; PRK09450
498217000355	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
498217000356	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
498217000357	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
498217000358	putative iron binding site [ion binding]; other site
498217000359	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
498217000360	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
498217000361	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
498217000362	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
498217000363	hypothetical protein; Provisional; Region: PRK10963
498217000364	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
498217000365	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
498217000366	active site
498217000367	DNA binding site [nucleotide binding]
498217000368	Int/Topo IB signature motif; other site
498217000369	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
498217000370	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217000371	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
498217000372	Part of AAA domain; Region: AAA_19; pfam13245
498217000373	Family description; Region: UvrD_C_2; pfam13538
498217000374	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
498217000375	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
498217000376	Cl binding site [ion binding]; other site
498217000377	oligomer interface [polypeptide binding]; other site
498217000378	Putative ammonia monooxygenase; Region: AmoA; pfam05145
498217000379	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
498217000380	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
498217000381	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
498217000382	EamA-like transporter family; Region: EamA; cl17759
498217000383	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
498217000384	dimerization interface [polypeptide binding]; other site
498217000385	substrate binding site [chemical binding]; other site
498217000386	active site
498217000387	calcium binding site [ion binding]; other site
498217000388	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
498217000389	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498217000390	ATP binding site [chemical binding]; other site
498217000391	putative Mg++ binding site [ion binding]; other site
498217000392	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498217000393	nucleotide binding region [chemical binding]; other site
498217000394	ATP-binding site [chemical binding]; other site
498217000395	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
498217000396	HRDC domain; Region: HRDC; pfam00570
498217000397	Uncharacterized conserved protein [Function unknown]; Region: COG1912
498217000398	threonine efflux system; Provisional; Region: PRK10229
498217000399	low affinity gluconate transporter; Provisional; Region: PRK10472
498217000400	gluconate transporter; Region: gntP; TIGR00791
498217000401	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
498217000402	ATP-binding site [chemical binding]; other site
498217000403	Gluconate-6-phosphate binding site [chemical binding]; other site
498217000404	Shikimate kinase; Region: SKI; pfam01202
498217000405	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
498217000406	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
498217000407	DNA binding site [nucleotide binding]
498217000408	domain linker motif; other site
498217000409	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
498217000410	putative ligand binding site [chemical binding]; other site
498217000411	putative dimerization interface [polypeptide binding]; other site
498217000412	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
498217000413	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
498217000414	metal-binding site [ion binding]
498217000415	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
498217000416	Soluble P-type ATPase [General function prediction only]; Region: COG4087
498217000417	Surface antigen; Region: Bac_surface_Ag; pfam01103
498217000418	Protein of unknown function (DUF4056); Region: DUF4056; pfam13265
498217000419	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
498217000420	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
498217000421	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
498217000422	THF binding site; other site
498217000423	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
498217000424	substrate binding site [chemical binding]; other site
498217000425	THF binding site; other site
498217000426	zinc-binding site [ion binding]; other site
498217000427	uridine phosphorylase; Provisional; Region: PRK11178
498217000428	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
498217000429	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
498217000430	Carbon starvation protein CstA; Region: CstA; pfam02554
498217000431	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
498217000432	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
498217000433	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
498217000434	DNA recombination protein RmuC; Provisional; Region: PRK10361
498217000435	RmuC family; Region: RmuC; pfam02646
498217000436	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
498217000437	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217000438	S-adenosylmethionine binding site [chemical binding]; other site
498217000439	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
498217000440	SCP-2 sterol transfer family; Region: SCP2; pfam02036
498217000441	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
498217000442	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
498217000443	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
498217000444	sec-independent translocase; Provisional; Region: PRK01770
498217000445	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
498217000446	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
498217000447	active site
498217000448	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
498217000449	dimer interface [polypeptide binding]; other site
498217000450	active site
498217000451	aspartate-rich active site metal binding site; other site
498217000452	allosteric magnesium binding site [ion binding]; other site
498217000453	Schiff base residues; other site
498217000454	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
498217000455	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
498217000456	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
498217000457	heterodimer interface [polypeptide binding]; other site
498217000458	homodimer interface [polypeptide binding]; other site
498217000459	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
498217000460	active site pocket [active]
498217000461	oxyanion hole [active]
498217000462	catalytic triad [active]
498217000463	active site nucleophile [active]
498217000464	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
498217000465	FMN reductase; Validated; Region: fre; PRK08051
498217000466	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
498217000467	FAD binding pocket [chemical binding]; other site
498217000468	FAD binding motif [chemical binding]; other site
498217000469	phosphate binding motif [ion binding]; other site
498217000470	beta-alpha-beta structure motif; other site
498217000471	NAD binding pocket [chemical binding]; other site
498217000472	proline dipeptidase; Provisional; Region: PRK13607
498217000473	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
498217000474	active site
498217000475	hypothetical protein; Provisional; Region: PRK11568
498217000476	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
498217000477	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
498217000478	potassium transporter; Provisional; Region: PRK10750
498217000479	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
498217000480	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
498217000481	Transposase; Region: HTH_Tnp_1; pfam01527
498217000482	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
498217000483	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
498217000484	FAD binding domain; Region: FAD_binding_4; pfam01565
498217000485	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
498217000486	Biotin operon repressor [Transcription]; Region: BirA; COG1654
498217000487	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
498217000488	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
498217000489	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
498217000490	pantothenate kinase; Provisional; Region: PRK05439
498217000491	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
498217000492	ATP-binding site [chemical binding]; other site
498217000493	CoA-binding site [chemical binding]; other site
498217000494	Mg2+-binding site [ion binding]; other site
498217000495	elongation factor Tu; Reviewed; Region: PRK00049
498217000496	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
498217000497	G1 box; other site
498217000498	GEF interaction site [polypeptide binding]; other site
498217000499	GTP/Mg2+ binding site [chemical binding]; other site
498217000500	Switch I region; other site
498217000501	G2 box; other site
498217000502	G3 box; other site
498217000503	Switch II region; other site
498217000504	G4 box; other site
498217000505	G5 box; other site
498217000506	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
498217000507	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
498217000508	Antibiotic Binding Site [chemical binding]; other site
498217000509	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
498217000510	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
498217000511	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
498217000512	putative homodimer interface [polypeptide binding]; other site
498217000513	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
498217000514	heterodimer interface [polypeptide binding]; other site
498217000515	homodimer interface [polypeptide binding]; other site
498217000516	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
498217000517	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
498217000518	23S rRNA interface [nucleotide binding]; other site
498217000519	L7/L12 interface [polypeptide binding]; other site
498217000520	putative thiostrepton binding site; other site
498217000521	L25 interface [polypeptide binding]; other site
498217000522	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
498217000523	mRNA/rRNA interface [nucleotide binding]; other site
498217000524	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
498217000525	23S rRNA interface [nucleotide binding]; other site
498217000526	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
498217000527	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
498217000528	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
498217000529	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
498217000530	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
498217000531	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
498217000532	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
498217000533	RPB3 interaction site [polypeptide binding]; other site
498217000534	RPB1 interaction site [polypeptide binding]; other site
498217000535	RPB11 interaction site [polypeptide binding]; other site
498217000536	RPB10 interaction site [polypeptide binding]; other site
498217000537	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
498217000538	DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386
498217000539	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
498217000540	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
498217000541	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
498217000542	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
498217000543	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
498217000544	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
498217000545	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
498217000546	DNA binding site [nucleotide binding]
498217000547	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
498217000548	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
498217000549	thiamine phosphate binding site [chemical binding]; other site
498217000550	active site
498217000551	pyrophosphate binding site [ion binding]; other site
498217000552	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
498217000553	ThiC-associated domain; Region: ThiC-associated; pfam13667
498217000554	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
498217000555	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
498217000556	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
498217000557	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
498217000558	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
498217000559	putative NADH binding site [chemical binding]; other site
498217000560	putative active site [active]
498217000561	nudix motif; other site
498217000562	putative metal binding site [ion binding]; other site
498217000563	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
498217000564	substrate binding site [chemical binding]; other site
498217000565	active site
498217000566	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
498217000567	Active_site [active]
498217000568	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
498217000569	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
498217000570	IHF dimer interface [polypeptide binding]; other site
498217000571	IHF - DNA interface [nucleotide binding]; other site
498217000572	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
498217000573	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
498217000574	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
498217000575	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
498217000576	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
498217000577	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
498217000578	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
498217000579	purine monophosphate binding site [chemical binding]; other site
498217000580	dimer interface [polypeptide binding]; other site
498217000581	putative catalytic residues [active]
498217000582	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
498217000583	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
498217000584	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
498217000585	acetyl-CoA synthetase; Provisional; Region: PRK00174
498217000586	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
498217000587	active site
498217000588	CoA binding site [chemical binding]; other site
498217000589	acyl-activating enzyme (AAE) consensus motif; other site
498217000590	AMP binding site [chemical binding]; other site
498217000591	acetate binding site [chemical binding]; other site
498217000592	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
498217000593	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
498217000594	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
498217000595	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
498217000596	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
498217000597	dimer interface [polypeptide binding]; other site
498217000598	ADP-ribose binding site [chemical binding]; other site
498217000599	active site
498217000600	nudix motif; other site
498217000601	metal binding site [ion binding]; metal-binding site
498217000602	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
498217000603	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
498217000604	active site
498217000605	metal binding site [ion binding]; metal-binding site
498217000606	hexamer interface [polypeptide binding]; other site
498217000607	esterase YqiA; Provisional; Region: PRK11071
498217000608	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
498217000609	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217000610	ATP binding site [chemical binding]; other site
498217000611	Mg2+ binding site [ion binding]; other site
498217000612	G-X-G motif; other site
498217000613	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
498217000614	anchoring element; other site
498217000615	dimer interface [polypeptide binding]; other site
498217000616	ATP binding site [chemical binding]; other site
498217000617	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
498217000618	active site
498217000619	metal binding site [ion binding]; metal-binding site
498217000620	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
498217000621	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
498217000622	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
498217000623	CAP-like domain; other site
498217000624	active site
498217000625	primary dimer interface [polypeptide binding]; other site
498217000626	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
498217000627	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
498217000628	putative acyl-acceptor binding pocket; other site
498217000629	FtsI repressor; Provisional; Region: PRK10883
498217000630	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
498217000631	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
498217000632	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
498217000633	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
498217000634	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
498217000635	substrate binding pocket [chemical binding]; other site
498217000636	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
498217000637	B12 binding site [chemical binding]; other site
498217000638	cobalt ligand [ion binding]; other site
498217000639	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
498217000640	aspartate kinase III; Validated; Region: PRK09084
498217000641	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
498217000642	nucleotide binding site [chemical binding]; other site
498217000643	substrate binding site [chemical binding]; other site
498217000644	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932
498217000645	lysine allosteric regulatory site; other site
498217000646	dimer interface [polypeptide binding]; other site
498217000647	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
498217000648	dimer interface [polypeptide binding]; other site
498217000649	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
498217000650	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
498217000651	active site
498217000652	dimer interface [polypeptide binding]; other site
498217000653	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
498217000654	dimer interface [polypeptide binding]; other site
498217000655	active site
498217000656	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
498217000657	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
498217000658	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
498217000659	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
498217000660	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217000661	dimer interface [polypeptide binding]; other site
498217000662	conserved gate region; other site
498217000663	putative PBP binding loops; other site
498217000664	ABC-ATPase subunit interface; other site
498217000665	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217000666	dimer interface [polypeptide binding]; other site
498217000667	conserved gate region; other site
498217000668	putative PBP binding loops; other site
498217000669	ABC-ATPase subunit interface; other site
498217000670	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
498217000671	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
498217000672	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
498217000673	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
498217000674	Walker A/P-loop; other site
498217000675	ATP binding site [chemical binding]; other site
498217000676	Q-loop/lid; other site
498217000677	ABC transporter signature motif; other site
498217000678	Walker B; other site
498217000679	D-loop; other site
498217000680	H-loop/switch region; other site
498217000681	TOBE domain; Region: TOBE_2; pfam08402
498217000682	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
498217000683	trimer interface; other site
498217000684	sugar binding site [chemical binding]; other site
498217000685	maltose regulon periplasmic protein; Provisional; Region: PRK10564
498217000686	Chorismate lyase; Region: Chor_lyase; cl01230
498217000687	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
498217000688	UbiA prenyltransferase family; Region: UbiA; pfam01040
498217000689	Major Facilitator Superfamily; Region: MFS_1; pfam07690
498217000690	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217000691	putative substrate translocation pore; other site
498217000692	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
498217000693	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
498217000694	putative acyl-acceptor binding pocket; other site
498217000695	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
498217000696	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
498217000697	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
498217000698	transmembrane helices; other site
498217000699	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
498217000700	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802
498217000701	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
498217000702	Coenzyme A transferase; Region: CoA_trans; cl17247
498217000703	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
498217000704	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
498217000705	citrate lyase subunit gamma; Provisional; Region: PRK13253
498217000706	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
498217000707	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
498217000708	active site
498217000709	nucleotide binding site [chemical binding]; other site
498217000710	HIGH motif; other site
498217000711	KMSKS motif; other site
498217000712	sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053
498217000713	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
498217000714	putative active site [active]
498217000715	heme pocket [chemical binding]; other site
498217000716	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217000717	ATP binding site [chemical binding]; other site
498217000718	Mg2+ binding site [ion binding]; other site
498217000719	G-X-G motif; other site
498217000720	two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046
498217000721	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217000722	active site
498217000723	phosphorylation site [posttranslational modification]
498217000724	intermolecular recognition site; other site
498217000725	dimerization interface [polypeptide binding]; other site
498217000726	Transcriptional regulator; Region: CitT; pfam12431
498217000727	LexA repressor; Validated; Region: PRK00215
498217000728	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
498217000729	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
498217000730	Catalytic site [active]
498217000731	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
498217000732	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
498217000733	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
498217000734	metal binding site 2 [ion binding]; metal-binding site
498217000735	putative DNA binding helix; other site
498217000736	metal binding site 1 [ion binding]; metal-binding site
498217000737	dimer interface [polypeptide binding]; other site
498217000738	structural Zn2+ binding site [ion binding]; other site
498217000739	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
498217000740	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
498217000741	FMN binding site [chemical binding]; other site
498217000742	active site
498217000743	catalytic residues [active]
498217000744	substrate binding site [chemical binding]; other site
498217000745	Phage shock protein G (Phageshock_PspG); Region: Phageshock_PspG; cl11511
498217000746	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
498217000747	replicative DNA helicase; Provisional; Region: PRK08006
498217000748	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
498217000749	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
498217000750	Walker A motif; other site
498217000751	ATP binding site [chemical binding]; other site
498217000752	Walker B motif; other site
498217000753	DNA binding loops [nucleotide binding]
498217000754	alanine racemase; Reviewed; Region: alr; PRK00053
498217000755	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
498217000756	active site
498217000757	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
498217000758	substrate binding site [chemical binding]; other site
498217000759	catalytic residues [active]
498217000760	dimer interface [polypeptide binding]; other site
498217000761	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
498217000762	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
498217000763	dimer interface [polypeptide binding]; other site
498217000764	active site
498217000765	metal binding site [ion binding]; metal-binding site
498217000766	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
498217000767	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
498217000768	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
498217000769	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
498217000770	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
498217000771	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
498217000772	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
498217000773	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
498217000774	E-class dimer interface [polypeptide binding]; other site
498217000775	P-class dimer interface [polypeptide binding]; other site
498217000776	active site
498217000777	Cu2+ binding site [ion binding]; other site
498217000778	Zn2+ binding site [ion binding]; other site
498217000779	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
498217000780	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
498217000781	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
498217000782	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
498217000783	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
498217000784	[4Fe-4S] binding site [ion binding]; other site
498217000785	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
498217000786	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
498217000787	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
498217000788	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
498217000789	molybdopterin cofactor binding site; other site
498217000790	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
498217000791	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
498217000792	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
498217000793	Protein of unknown function (DUF2618); Region: DUF2618; pfam10940
498217000794	potential frameshift: common BLAST hit: gi|238921268|ref|YP_002934783.1| Orn/Lys/Arg decarboxylase family
498217000795	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
498217000796	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
498217000797	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
498217000798	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
498217000799	catalytic residue [active]
498217000800	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
498217000801	putrescine transporter; Provisional; Region: potE; PRK10655
498217000802	nickel responsive regulator; Provisional; Region: PRK02967
498217000803	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
498217000804	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
498217000805	murein transglycosylase C; Provisional; Region: mltC; PRK11671
498217000806	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
498217000807	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
498217000808	N-acetyl-D-glucosamine binding site [chemical binding]; other site
498217000809	catalytic residue [active]
498217000810	oxidative damage protection protein; Provisional; Region: PRK05408
498217000811	adenine DNA glycosylase; Provisional; Region: PRK10880
498217000812	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
498217000813	minor groove reading motif; other site
498217000814	helix-hairpin-helix signature motif; other site
498217000815	substrate binding pocket [chemical binding]; other site
498217000816	active site
498217000817	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
498217000818	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
498217000819	DNA binding and oxoG recognition site [nucleotide binding]
498217000820	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217000821	S-adenosylmethionine binding site [chemical binding]; other site
498217000822	hypothetical protein; Provisional; Region: PRK11702
498217000823	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
498217000824	glutaminase; Provisional; Region: PRK00971
498217000825	hypothetical protein; Provisional; Region: PRK10626
498217000826	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
498217000827	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
498217000828	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
498217000829	peptide binding site [polypeptide binding]; other site
498217000830	HemN family oxidoreductase; Provisional; Region: PRK05660
498217000831	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
498217000832	FeS/SAM binding site; other site
498217000833	HemN C-terminal domain; Region: HemN_C; pfam06969
498217000834	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
498217000835	active site
498217000836	dimerization interface [polypeptide binding]; other site
498217000837	hypothetical protein; Validated; Region: PRK05090
498217000838	YGGT family; Region: YGGT; pfam02325
498217000839	YGGT family; Region: YGGT; pfam02325
498217000840	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
498217000841	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
498217000842	catalytic residue [active]
498217000843	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
498217000844	hypothetical protein; Validated; Region: PRK00228
498217000845	glutathione synthetase; Provisional; Region: PRK05246
498217000846	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
498217000847	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
498217000848	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
498217000849	RNA methyltransferase, RsmE family; Region: TIGR00046
498217000850	DNA-specific endonuclease I; Provisional; Region: PRK15137
498217000851	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
498217000852	hypothetical protein; Provisional; Region: PRK04860
498217000853	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
498217000854	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
498217000855	lysine decarboxylase CadA; Provisional; Region: PRK15400
498217000856	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
498217000857	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
498217000858	homodimer interface [polypeptide binding]; other site
498217000859	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217000860	catalytic residue [active]
498217000861	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
498217000862	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
498217000863	hypothetical protein; Provisional; Region: PRK11653
498217000864	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
498217000865	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498217000866	DNA-binding site [nucleotide binding]; DNA binding site
498217000867	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498217000868	L-fucose mutarotase; Provisional; Region: fucU; PRK15420
498217000869	L-fuculokinase; Provisional; Region: PRK10331
498217000870	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
498217000871	nucleotide binding site [chemical binding]; other site
498217000872	L-fucose isomerase; Provisional; Region: fucI; PRK10991
498217000873	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
498217000874	hexamer (dimer of trimers) interface [polypeptide binding]; other site
498217000875	trimer interface [polypeptide binding]; other site
498217000876	substrate binding site [chemical binding]; other site
498217000877	Mn binding site [ion binding]; other site
498217000878	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
498217000879	L-fucose transporter; Provisional; Region: PRK10133; cl17665
498217000880	DNA polymerase type B, organellar and viral; Region: DNA_pol_B_2; pfam03175
498217000881	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
498217000882	intersubunit interface [polypeptide binding]; other site
498217000883	active site
498217000884	Zn2+ binding site [ion binding]; other site
498217000885	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
498217000886	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
498217000887	dimer interface [polypeptide binding]; other site
498217000888	active site
498217000889	metal binding site [ion binding]; metal-binding site
498217000890	acid-resistance membrane protein; Provisional; Region: PRK10209
498217000891	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
498217000892	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
498217000893	chaperone protein TorD; Validated; Region: torD; PRK04976
498217000894	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
498217000895	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
498217000896	molybdopterin cofactor binding site [chemical binding]; other site
498217000897	substrate binding site [chemical binding]; other site
498217000898	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
498217000899	molybdopterin cofactor binding site; other site
498217000900	trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032
498217000901	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
498217000902	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
498217000903	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217000904	active site
498217000905	phosphorylation site [posttranslational modification]
498217000906	intermolecular recognition site; other site
498217000907	dimerization interface [polypeptide binding]; other site
498217000908	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498217000909	DNA binding site [nucleotide binding]
498217000910	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
498217000911	TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306
498217000912	putative ligand binding site [chemical binding]; other site
498217000913	hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466
498217000914	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217000915	dimer interface [polypeptide binding]; other site
498217000916	phosphorylation site [posttranslational modification]
498217000917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217000918	ATP binding site [chemical binding]; other site
498217000919	Mg2+ binding site [ion binding]; other site
498217000920	G-X-G motif; other site
498217000921	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217000922	active site
498217000923	phosphorylation site [posttranslational modification]
498217000924	intermolecular recognition site; other site
498217000925	dimerization interface [polypeptide binding]; other site
498217000926	Hpt domain; Region: Hpt; pfam01627
498217000927	hypothetical protein; Provisional; Region: PRK10316
498217000928	YfdX protein; Region: YfdX; pfam10938
498217000929	putative transcriptional regulator; Provisional; Region: PRK11640
498217000930	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
498217000931	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
498217000932	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
498217000933	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
498217000934	DsbD alpha interface [polypeptide binding]; other site
498217000935	catalytic residues [active]
498217000936	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
498217000937	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
498217000938	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
498217000939	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
498217000940	Aspartase; Region: Aspartase; cd01357
498217000941	active sites [active]
498217000942	tetramer interface [polypeptide binding]; other site
498217000943	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
498217000944	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
498217000945	oligomerisation interface [polypeptide binding]; other site
498217000946	mobile loop; other site
498217000947	roof hairpin; other site
498217000948	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
498217000949	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
498217000950	ring oligomerisation interface [polypeptide binding]; other site
498217000951	ATP/Mg binding site [chemical binding]; other site
498217000952	stacking interactions; other site
498217000953	hinge regions; other site
498217000954	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
498217000955	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
498217000956	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
498217000957	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
498217000958	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
498217000959	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
498217000960	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
498217000961	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
498217000962	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
498217000963	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
498217000964	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
498217000965	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
498217000966	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
498217000967	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
498217000968	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
498217000969	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
498217000970	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
498217000971	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
498217000972	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
498217000973	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
498217000974	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
498217000975	HlyD family secretion protein; Region: HlyD_3; pfam13437
498217000976	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
498217000977	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
498217000978	Walker A/P-loop; other site
498217000979	ATP binding site [chemical binding]; other site
498217000980	Q-loop/lid; other site
498217000981	ABC transporter signature motif; other site
498217000982	Walker B; other site
498217000983	D-loop; other site
498217000984	H-loop/switch region; other site
498217000985	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
498217000986	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
498217000987	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
498217000988	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
498217000989	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
498217000990	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
498217000991	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
498217000992	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
498217000993	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
498217000994	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
498217000995	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
498217000996	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
498217000997	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
498217000998	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
498217000999	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
498217001000	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
498217001001	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
498217001002	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
498217001003	Uncharacterized conserved protein [Function unknown]; Region: COG1556
498217001004	iron-sulfur cluster-binding protein; Region: TIGR00273
498217001005	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
498217001006	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
498217001007	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
498217001008	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
498217001009	Cysteine-rich domain; Region: CCG; pfam02754
498217001010	Cysteine-rich domain; Region: CCG; pfam02754
498217001011	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
498217001012	L-lactate permease; Region: Lactate_perm; cl00701
498217001013	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
498217001014	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
498217001015	FeS/SAM binding site; other site
498217001016	elongation factor P; Validated; Region: PRK00529
498217001017	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
498217001018	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
498217001019	RNA binding site [nucleotide binding]; other site
498217001020	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
498217001021	RNA binding site [nucleotide binding]; other site
498217001022	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
498217001023	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
498217001024	Iron-sulfur protein interface; other site
498217001025	proximal quinone binding site [chemical binding]; other site
498217001026	C-subunit interface; other site
498217001027	distal quinone binding site; other site
498217001028	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
498217001029	D-subunit interface [polypeptide binding]; other site
498217001030	Iron-sulfur protein interface; other site
498217001031	proximal quinone binding site [chemical binding]; other site
498217001032	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
498217001033	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
498217001034	catalytic loop [active]
498217001035	iron binding site [ion binding]; other site
498217001036	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
498217001037	L-aspartate oxidase; Provisional; Region: PRK06175
498217001038	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
498217001039	poxB regulator PoxA; Provisional; Region: PRK09350
498217001040	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
498217001041	motif 1; other site
498217001042	dimer interface [polypeptide binding]; other site
498217001043	active site
498217001044	motif 2; other site
498217001045	motif 3; other site
498217001046	putative mechanosensitive channel protein; Provisional; Region: PRK10929
498217001047	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
498217001048	Mechanosensitive ion channel; Region: MS_channel; pfam00924
498217001049	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
498217001050	GTPase RsgA; Reviewed; Region: PRK12288
498217001051	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
498217001052	RNA binding site [nucleotide binding]; other site
498217001053	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
498217001054	GTPase/Zn-binding domain interface [polypeptide binding]; other site
498217001055	GTP/Mg2+ binding site [chemical binding]; other site
498217001056	G4 box; other site
498217001057	G5 box; other site
498217001058	G1 box; other site
498217001059	Switch I region; other site
498217001060	G2 box; other site
498217001061	G3 box; other site
498217001062	Switch II region; other site
498217001063	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
498217001064	catalytic site [active]
498217001065	putative active site [active]
498217001066	putative substrate binding site [chemical binding]; other site
498217001067	dimer interface [polypeptide binding]; other site
498217001068	epoxyqueuosine reductase; Region: TIGR00276
498217001069	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
498217001070	putative carbohydrate kinase; Provisional; Region: PRK10565
498217001071	Uncharacterized conserved protein [Function unknown]; Region: COG0062
498217001072	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
498217001073	putative substrate binding site [chemical binding]; other site
498217001074	putative ATP binding site [chemical binding]; other site
498217001075	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
498217001076	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
498217001077	AMIN domain; Region: AMIN; pfam11741
498217001078	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
498217001079	active site
498217001080	metal binding site [ion binding]; metal-binding site
498217001081	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
498217001082	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
498217001083	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
498217001084	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217001085	ATP binding site [chemical binding]; other site
498217001086	Mg2+ binding site [ion binding]; other site
498217001087	G-X-G motif; other site
498217001088	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
498217001089	ATP binding site [chemical binding]; other site
498217001090	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
498217001091	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
498217001092	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
498217001093	bacterial Hfq-like; Region: Hfq; cd01716
498217001094	hexamer interface [polypeptide binding]; other site
498217001095	Sm1 motif; other site
498217001096	RNA binding site [nucleotide binding]; other site
498217001097	Sm2 motif; other site
498217001098	GTPase HflX; Provisional; Region: PRK11058
498217001099	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
498217001100	HflX GTPase family; Region: HflX; cd01878
498217001101	G1 box; other site
498217001102	GTP/Mg2+ binding site [chemical binding]; other site
498217001103	Switch I region; other site
498217001104	G2 box; other site
498217001105	G3 box; other site
498217001106	Switch II region; other site
498217001107	G4 box; other site
498217001108	G5 box; other site
498217001109	FtsH protease regulator HflK; Provisional; Region: PRK10930
498217001110	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
498217001111	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
498217001112	FtsH protease regulator HflC; Provisional; Region: PRK11029
498217001113	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
498217001114	Acyltransferase family; Region: Acyl_transf_3; pfam01757
498217001115	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
498217001116	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
498217001117	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
498217001118	GDP-binding site [chemical binding]; other site
498217001119	ACT binding site; other site
498217001120	IMP binding site; other site
498217001121	transcriptional repressor NsrR; Provisional; Region: PRK11014
498217001122	Predicted transcriptional regulator [Transcription]; Region: COG1959
498217001123	exoribonuclease R; Provisional; Region: PRK11642
498217001124	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
498217001125	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
498217001126	RNB domain; Region: RNB; pfam00773
498217001127	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
498217001128	RNA binding site [nucleotide binding]; other site
498217001129	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
498217001130	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
498217001131	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
498217001132	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
498217001133	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
498217001134	esterase; Provisional; Region: PRK10566
498217001135	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
498217001136	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
498217001137	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
498217001138	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
498217001139	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
498217001140	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
498217001141	Protein of unknown function, DUF488; Region: DUF488; cl01246
498217001142	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
498217001143	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
498217001144	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
498217001145	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
498217001146	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
498217001147	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
498217001148	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
498217001149	Hemerythrin-like domain; Region: Hr-like; cd12108
498217001150	Fe binding site [ion binding]; other site
498217001151	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
498217001152	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
498217001153	active site
498217001154	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
498217001155	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
498217001156	Domain of unknown function DUF21; Region: DUF21; pfam01595
498217001157	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
498217001158	Transporter associated domain; Region: CorC_HlyC; smart01091
498217001159	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
498217001160	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
498217001161	Surface antigen; Region: Bac_surface_Ag; pfam01103
498217001162	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
498217001163	Family of unknown function (DUF490); Region: DUF490; pfam04357
498217001164	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
498217001165	putative active site pocket [active]
498217001166	dimerization interface [polypeptide binding]; other site
498217001167	putative catalytic residue [active]
498217001168	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
498217001169	dimer interface [polypeptide binding]; other site
498217001170	substrate binding site [chemical binding]; other site
498217001171	metal binding sites [ion binding]; metal-binding site
498217001172	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
498217001173	AMP binding site [chemical binding]; other site
498217001174	metal binding site [ion binding]; metal-binding site
498217001175	active site
498217001176	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
498217001177	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
498217001178	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
498217001179	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
498217001180	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
498217001181	arginine repressor; Provisional; Region: PRK05066
498217001182	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
498217001183	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
498217001184	malate dehydrogenase; Provisional; Region: PRK05086
498217001185	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
498217001186	NAD binding site [chemical binding]; other site
498217001187	dimerization interface [polypeptide binding]; other site
498217001188	Substrate binding site [chemical binding]; other site
498217001189	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
498217001190	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
498217001191	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
498217001192	substrate binding pocket [chemical binding]; other site
498217001193	chain length determination region; other site
498217001194	substrate-Mg2+ binding site; other site
498217001195	catalytic residues [active]
498217001196	aspartate-rich region 1; other site
498217001197	active site lid residues [active]
498217001198	aspartate-rich region 2; other site
498217001199	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
498217001200	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
498217001201	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
498217001202	EamA-like transporter family; Region: EamA; pfam00892
498217001203	EamA-like transporter family; Region: EamA; pfam00892
498217001204	GTPase CgtA; Reviewed; Region: obgE; PRK12298
498217001205	GTP1/OBG; Region: GTP1_OBG; pfam01018
498217001206	Obg GTPase; Region: Obg; cd01898
498217001207	G1 box; other site
498217001208	GTP/Mg2+ binding site [chemical binding]; other site
498217001209	Switch I region; other site
498217001210	G2 box; other site
498217001211	G3 box; other site
498217001212	Switch II region; other site
498217001213	G4 box; other site
498217001214	G5 box; other site
498217001215	sensor protein BasS/PmrB; Provisional; Region: PRK10755
498217001216	HAMP domain; Region: HAMP; pfam00672
498217001217	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217001218	dimer interface [polypeptide binding]; other site
498217001219	phosphorylation site [posttranslational modification]
498217001220	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217001221	ATP binding site [chemical binding]; other site
498217001222	Mg2+ binding site [ion binding]; other site
498217001223	G-X-G motif; other site
498217001224	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
498217001225	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217001226	active site
498217001227	phosphorylation site [posttranslational modification]
498217001228	intermolecular recognition site; other site
498217001229	dimerization interface [polypeptide binding]; other site
498217001230	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498217001231	DNA binding site [nucleotide binding]
498217001232	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
498217001233	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
498217001234	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
498217001235	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
498217001236	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
498217001237	RNA-binding protein YhbY; Provisional; Region: PRK10343
498217001238	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
498217001239	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217001240	S-adenosylmethionine binding site [chemical binding]; other site
498217001241	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
498217001242	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217001243	Walker A motif; other site
498217001244	ATP binding site [chemical binding]; other site
498217001245	Walker B motif; other site
498217001246	arginine finger; other site
498217001247	Peptidase family M41; Region: Peptidase_M41; pfam01434
498217001248	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
498217001249	dihydropteroate synthase; Region: DHPS; TIGR01496
498217001250	substrate binding pocket [chemical binding]; other site
498217001251	dimer interface [polypeptide binding]; other site
498217001252	inhibitor binding site; inhibition site
498217001253	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
498217001254	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
498217001255	active site
498217001256	substrate binding site [chemical binding]; other site
498217001257	metal binding site [ion binding]; metal-binding site
498217001258	Preprotein translocase SecG subunit; Region: SecG; pfam03840
498217001259	ribosome maturation protein RimP; Reviewed; Region: PRK00092
498217001260	hypothetical protein; Provisional; Region: PRK14641
498217001261	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
498217001262	putative oligomer interface [polypeptide binding]; other site
498217001263	putative RNA binding site [nucleotide binding]; other site
498217001264	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
498217001265	NusA N-terminal domain; Region: NusA_N; pfam08529
498217001266	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
498217001267	RNA binding site [nucleotide binding]; other site
498217001268	homodimer interface [polypeptide binding]; other site
498217001269	NusA-like KH domain; Region: KH_5; pfam13184
498217001270	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
498217001271	G-X-X-G motif; other site
498217001272	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
498217001273	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
498217001274	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
498217001275	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
498217001276	translation initiation factor IF-2; Validated; Region: infB; PRK05306
498217001277	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
498217001278	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
498217001279	G1 box; other site
498217001280	putative GEF interaction site [polypeptide binding]; other site
498217001281	GTP/Mg2+ binding site [chemical binding]; other site
498217001282	Switch I region; other site
498217001283	G2 box; other site
498217001284	G3 box; other site
498217001285	Switch II region; other site
498217001286	G4 box; other site
498217001287	G5 box; other site
498217001288	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
498217001289	Translation-initiation factor 2; Region: IF-2; pfam11987
498217001290	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
498217001291	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
498217001292	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
498217001293	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
498217001294	RNA binding site [nucleotide binding]; other site
498217001295	active site
498217001296	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
498217001297	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
498217001298	16S/18S rRNA binding site [nucleotide binding]; other site
498217001299	S13e-L30e interaction site [polypeptide binding]; other site
498217001300	25S rRNA binding site [nucleotide binding]; other site
498217001301	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
498217001302	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
498217001303	RNase E interface [polypeptide binding]; other site
498217001304	trimer interface [polypeptide binding]; other site
498217001305	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
498217001306	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
498217001307	RNase E interface [polypeptide binding]; other site
498217001308	trimer interface [polypeptide binding]; other site
498217001309	active site
498217001310	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
498217001311	putative nucleic acid binding region [nucleotide binding]; other site
498217001312	G-X-X-G motif; other site
498217001313	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
498217001314	RNA binding site [nucleotide binding]; other site
498217001315	domain interface; other site
498217001316	lipoprotein NlpI; Provisional; Region: PRK11189
498217001317	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
498217001318	binding surface
498217001319	TPR motif; other site
498217001320	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
498217001321	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
498217001322	ATP binding site [chemical binding]; other site
498217001323	Mg++ binding site [ion binding]; other site
498217001324	motif III; other site
498217001325	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498217001326	nucleotide binding region [chemical binding]; other site
498217001327	ATP-binding site [chemical binding]; other site
498217001328	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
498217001329	putative RNA binding site [nucleotide binding]; other site
498217001330	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
498217001331	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
498217001332	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
498217001333	putative protease; Provisional; Region: PRK15447
498217001334	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
498217001335	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
498217001336	Peptidase family U32; Region: Peptidase_U32; pfam01136
498217001337	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
498217001338	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
498217001339	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498217001340	Coenzyme A binding pocket [chemical binding]; other site
498217001341	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
498217001342	Na binding site [ion binding]; other site
498217001343	hypothetical protein; Provisional; Region: PRK03467
498217001344	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
498217001345	NADH(P)-binding; Region: NAD_binding_10; pfam13460
498217001346	NAD binding site [chemical binding]; other site
498217001347	active site
498217001348	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121
498217001349	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
498217001350	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
498217001351	ATP cone domain; Region: ATP-cone; pfam03477
498217001352	Class III ribonucleotide reductase; Region: RNR_III; cd01675
498217001353	effector binding site; other site
498217001354	active site
498217001355	Zn binding site [ion binding]; other site
498217001356	glycine loop; other site
498217001357	YqjK-like protein; Region: YqjK; pfam13997
498217001358	Predicted membrane protein [Function unknown]; Region: COG5393
498217001359	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
498217001360	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
498217001361	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
498217001362	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
498217001363	CrcB-like protein; Region: CRCB; cl09114
498217001364	DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523
498217001365	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498217001366	DNA-binding site [nucleotide binding]; DNA binding site
498217001367	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
498217001368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217001369	D-galactonate transporter; Region: 2A0114; TIGR00893
498217001370	putative substrate translocation pore; other site
498217001371	Glucuronate isomerase; Region: UxaC; pfam02614
498217001372	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
498217001373	altronate oxidoreductase; Provisional; Region: PRK03643
498217001374	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
498217001375	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
498217001376	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
498217001377	galactarate dehydratase; Region: galactar-dH20; TIGR03248
498217001378	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
498217001379	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
498217001380	serine/threonine transporter SstT; Provisional; Region: PRK13628
498217001381	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
498217001382	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
498217001383	EamA-like transporter family; Region: EamA; pfam00892
498217001384	EamA-like transporter family; Region: EamA; pfam00892
498217001385	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
498217001386	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
498217001387	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
498217001388	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
498217001389	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217001390	S-adenosylmethionine binding site [chemical binding]; other site
498217001391	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
498217001392	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498217001393	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217001394	homodimer interface [polypeptide binding]; other site
498217001395	catalytic residue [active]
498217001396	sensor protein QseC; Provisional; Region: PRK10337
498217001397	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
498217001398	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217001399	dimer interface [polypeptide binding]; other site
498217001400	phosphorylation site [posttranslational modification]
498217001401	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217001402	ATP binding site [chemical binding]; other site
498217001403	Mg2+ binding site [ion binding]; other site
498217001404	G-X-G motif; other site
498217001405	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
498217001406	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217001407	active site
498217001408	phosphorylation site [posttranslational modification]
498217001409	intermolecular recognition site; other site
498217001410	dimerization interface [polypeptide binding]; other site
498217001411	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498217001412	DNA binding site [nucleotide binding]
498217001413	Periplasmic protein with OB-fold [Function unknown]; Region: COG3111
498217001414	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
498217001415	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
498217001416	dimer interface [polypeptide binding]; other site
498217001417	active site
498217001418	glycine loop; other site
498217001419	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
498217001420	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
498217001421	FeS/SAM binding site; other site
498217001422	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
498217001423	active site
498217001424	intersubunit interactions; other site
498217001425	catalytic residue [active]
498217001426	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
498217001427	active site
498217001428	SUMO-1 interface [polypeptide binding]; other site
498217001429	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
498217001430	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
498217001431	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
498217001432	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
498217001433	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
498217001434	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
498217001435	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
498217001436	DNA binding residues [nucleotide binding]
498217001437	DNA primase; Validated; Region: dnaG; PRK05667
498217001438	CHC2 zinc finger; Region: zf-CHC2; pfam01807
498217001439	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
498217001440	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
498217001441	active site
498217001442	metal binding site [ion binding]; metal-binding site
498217001443	interdomain interaction site; other site
498217001444	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
498217001445	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
498217001446	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
498217001447	UGMP family protein; Validated; Region: PRK09604
498217001448	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
498217001449	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
498217001450	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
498217001451	homooctamer interface [polypeptide binding]; other site
498217001452	active site
498217001453	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
498217001454	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
498217001455	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
498217001456	active site
498217001457	NTP binding site [chemical binding]; other site
498217001458	metal binding triad [ion binding]; metal-binding site
498217001459	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
498217001460	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
498217001461	Zn2+ binding site [ion binding]; other site
498217001462	Mg2+ binding site [ion binding]; other site
498217001463	SH3 domain-containing protein; Provisional; Region: PRK10884
498217001464	Bacterial SH3 domain homologues; Region: SH3b; smart00287
498217001465	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
498217001466	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
498217001467	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
498217001468	Uncharacterized conserved protein [Function unknown]; Region: COG3025
498217001469	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
498217001470	putative active site [active]
498217001471	putative triphosphate binding site [ion binding]; other site
498217001472	putative metal binding residues [ion binding]; other site
498217001473	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
498217001474	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
498217001475	metal binding triad; other site
498217001476	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
498217001477	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
498217001478	metal binding triad; other site
498217001479	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
498217001480	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
498217001481	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
498217001482	putative acyl-acceptor binding pocket; other site
498217001483	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
498217001484	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
498217001485	putative ribose interaction site [chemical binding]; other site
498217001486	putative ADP binding site [chemical binding]; other site
498217001487	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
498217001488	active site
498217001489	nucleotide binding site [chemical binding]; other site
498217001490	HIGH motif; other site
498217001491	KMSKS motif; other site
498217001492	putative transporter; Provisional; Region: PRK11021
498217001493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
498217001494	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
498217001495	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
498217001496	zinc transporter ZupT; Provisional; Region: PRK04201
498217001497	ZIP Zinc transporter; Region: Zip; pfam02535
498217001498	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
498217001499	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
498217001500	putative active site [active]
498217001501	metal binding site [ion binding]; metal-binding site
498217001502	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
498217001503	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
498217001504	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217001505	S-adenosylmethionine binding site [chemical binding]; other site
498217001506	DNA polymerase III subunit psi; Validated; Region: PRK06856
498217001507	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
498217001508	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
498217001509	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
498217001510	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
498217001511	G1 box; other site
498217001512	putative GEF interaction site [polypeptide binding]; other site
498217001513	GTP/Mg2+ binding site [chemical binding]; other site
498217001514	Switch I region; other site
498217001515	G2 box; other site
498217001516	G3 box; other site
498217001517	Switch II region; other site
498217001518	G4 box; other site
498217001519	G5 box; other site
498217001520	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
498217001521	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
498217001522	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
498217001523	active site
498217001524	nucleophile elbow; other site
498217001525	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
498217001526	active site
498217001527	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
498217001528	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
498217001529	Nucleoside recognition; Region: Gate; pfam07670
498217001530	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
498217001531	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
498217001532	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
498217001533	hypothetical protein; Provisional; Region: PRK10977
498217001534	Pyruvate formate lyase; Region: PFL; pfam02901
498217001535	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
498217001536	intersubunit interface [polypeptide binding]; other site
498217001537	active site
498217001538	catalytic residue [active]
498217001539	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
498217001540	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
498217001541	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
498217001542	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
498217001543	phosphopentomutase; Provisional; Region: PRK05362
498217001544	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
498217001545	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
498217001546	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
498217001547	Cytochrome b562; Region: Cytochrom_B562; cl01546
498217001548	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
498217001549	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
498217001550	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
498217001551	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
498217001552	dimerization domain swap beta strand [polypeptide binding]; other site
498217001553	regulatory protein interface [polypeptide binding]; other site
498217001554	active site
498217001555	regulatory phosphorylation site [posttranslational modification]; other site
498217001556	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
498217001557	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
498217001558	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498217001559	active site
498217001560	phosphorylation site [posttranslational modification]
498217001561	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
498217001562	30S subunit binding site; other site
498217001563	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
498217001564	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
498217001565	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
498217001566	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
498217001567	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
498217001568	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
498217001569	Walker A/P-loop; other site
498217001570	ATP binding site [chemical binding]; other site
498217001571	Q-loop/lid; other site
498217001572	ABC transporter signature motif; other site
498217001573	Walker B; other site
498217001574	D-loop; other site
498217001575	H-loop/switch region; other site
498217001576	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
498217001577	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
498217001578	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
498217001579	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
498217001580	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
498217001581	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
498217001582	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
498217001583	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
498217001584	putative active site [active]
498217001585	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
498217001586	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
498217001587	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
498217001588	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
498217001589	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
498217001590	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
498217001591	Walker A/P-loop; other site
498217001592	ATP binding site [chemical binding]; other site
498217001593	Q-loop/lid; other site
498217001594	ABC transporter signature motif; other site
498217001595	Walker B; other site
498217001596	D-loop; other site
498217001597	H-loop/switch region; other site
498217001598	conserved hypothetical integral membrane protein; Region: TIGR00056
498217001599	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
498217001600	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
498217001601	mce related protein; Region: MCE; pfam02470
498217001602	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
498217001603	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
498217001604	anti sigma factor interaction site; other site
498217001605	regulatory phosphorylation site [posttranslational modification]; other site
498217001606	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
498217001607	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
498217001608	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
498217001609	hinge; other site
498217001610	active site
498217001611	serine endoprotease; Provisional; Region: PRK10898
498217001612	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
498217001613	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
498217001614	serine endoprotease; Provisional; Region: PRK10139
498217001615	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
498217001616	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
498217001617	protein binding site [polypeptide binding]; other site
498217001618	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
498217001619	protein binding site [polypeptide binding]; other site
498217001620	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
498217001621	hypothetical protein; Provisional; Region: PRK11677
498217001622	Predicted ATPase [General function prediction only]; Region: COG1485
498217001623	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
498217001624	23S rRNA interface [nucleotide binding]; other site
498217001625	L3 interface [polypeptide binding]; other site
498217001626	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
498217001627	stringent starvation protein A; Provisional; Region: sspA; PRK09481
498217001628	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
498217001629	C-terminal domain interface [polypeptide binding]; other site
498217001630	putative GSH binding site (G-site) [chemical binding]; other site
498217001631	dimer interface [polypeptide binding]; other site
498217001632	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
498217001633	dimer interface [polypeptide binding]; other site
498217001634	N-terminal domain interface [polypeptide binding]; other site
498217001635	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
498217001636	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
498217001637	N-acetylmannosamine kinase; Provisional; Region: PRK05082
498217001638	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
498217001639	nucleotide binding site [chemical binding]; other site
498217001640	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
498217001641	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
498217001642	putative active site cavity [active]
498217001643	putative disulfide oxidoreductase; Provisional; Region: PRK04307
498217001644	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
498217001645	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
498217001646	catalytic residues [active]
498217001647	hinge region; other site
498217001648	alpha helical domain; other site
498217001649	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
498217001650	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498217001651	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217001652	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
498217001653	substrate binding pocket [chemical binding]; other site
498217001654	dimerization interface [polypeptide binding]; other site
498217001655	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
498217001656	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
498217001657	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
498217001658	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498217001659	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
498217001660	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
498217001661	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
498217001662	active site
498217001663	dimer interface [polypeptide binding]; other site
498217001664	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
498217001665	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
498217001666	active site
498217001667	FMN binding site [chemical binding]; other site
498217001668	substrate binding site [chemical binding]; other site
498217001669	3Fe-4S cluster binding site [ion binding]; other site
498217001670	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
498217001671	domain interface; other site
498217001672	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
498217001673	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
498217001674	FeS/SAM binding site; other site
498217001675	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
498217001676	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
498217001677	putative active site [active]
498217001678	heme pocket [chemical binding]; other site
498217001679	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217001680	dimer interface [polypeptide binding]; other site
498217001681	phosphorylation site [posttranslational modification]
498217001682	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217001683	ATP binding site [chemical binding]; other site
498217001684	Mg2+ binding site [ion binding]; other site
498217001685	G-X-G motif; other site
498217001686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217001687	active site
498217001688	phosphorylation site [posttranslational modification]
498217001689	intermolecular recognition site; other site
498217001690	dimerization interface [polypeptide binding]; other site
498217001691	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
498217001692	putative binding surface; other site
498217001693	active site
498217001694	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
498217001695	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
498217001696	conserved cys residue [active]
498217001697	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
498217001698	Transglycosylase; Region: Transgly; cl17702
498217001699	outer membrane lipoprotein; Provisional; Region: PRK11023
498217001700	BON domain; Region: BON; pfam04972
498217001701	BON domain; Region: BON; pfam04972
498217001702	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
498217001703	dimer interface [polypeptide binding]; other site
498217001704	active site
498217001705	hypothetical protein; Reviewed; Region: PRK12497
498217001706	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
498217001707	putative ligand binding site [chemical binding]; other site
498217001708	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
498217001709	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
498217001710	putative SAM binding site [chemical binding]; other site
498217001711	putative homodimer interface [polypeptide binding]; other site
498217001712	hypothetical protein; Provisional; Region: PRK11246
498217001713	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
498217001714	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
498217001715	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217001716	motif II; other site
498217001717	DNA repair protein RadA; Provisional; Region: PRK11823
498217001718	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
498217001719	Walker A motif/ATP binding site; other site
498217001720	ATP binding site [chemical binding]; other site
498217001721	Walker B motif; other site
498217001722	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
498217001723	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
498217001724	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498217001725	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498217001726	ABC transporter; Region: ABC_tran_2; pfam12848
498217001727	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498217001728	lytic murein transglycosylase; Provisional; Region: PRK11619
498217001729	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
498217001730	N-acetyl-D-glucosamine binding site [chemical binding]; other site
498217001731	catalytic residue [active]
498217001732	Trp operon repressor; Provisional; Region: PRK01381
498217001733	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
498217001734	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
498217001735	catalytic core [active]
498217001736	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
498217001737	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
498217001738	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
498217001739	hypothetical protein; Provisional; Region: PRK10756
498217001740	CreA protein; Region: CreA; pfam05981
498217001741	prolyl-tRNA synthetase; Provisional; Region: PRK09194
498217001742	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
498217001743	dimer interface [polypeptide binding]; other site
498217001744	motif 1; other site
498217001745	active site
498217001746	motif 2; other site
498217001747	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
498217001748	putative deacylase active site [active]
498217001749	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
498217001750	active site
498217001751	motif 3; other site
498217001752	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
498217001753	anticodon binding site; other site
498217001754	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
498217001755	homodimer interaction site [polypeptide binding]; other site
498217001756	cofactor binding site; other site
498217001757	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
498217001758	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
498217001759	lipoprotein, YaeC family; Region: TIGR00363
498217001760	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217001761	dimer interface [polypeptide binding]; other site
498217001762	conserved gate region; other site
498217001763	ABC-ATPase subunit interface; other site
498217001764	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
498217001765	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
498217001766	Walker A/P-loop; other site
498217001767	ATP binding site [chemical binding]; other site
498217001768	Q-loop/lid; other site
498217001769	ABC transporter signature motif; other site
498217001770	Walker B; other site
498217001771	D-loop; other site
498217001772	H-loop/switch region; other site
498217001773	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
498217001774	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
498217001775	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217001776	active site
498217001777	motif I; other site
498217001778	motif II; other site
498217001779	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
498217001780	Mechanosensitive ion channel; Region: MS_channel; pfam00924
498217001781	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
498217001782	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
498217001783	domain interface [polypeptide binding]; other site
498217001784	putative active site [active]
498217001785	catalytic site [active]
498217001786	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
498217001787	domain interface [polypeptide binding]; other site
498217001788	putative active site [active]
498217001789	catalytic site [active]
498217001790	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
498217001791	CoA binding domain; Region: CoA_binding_2; pfam13380
498217001792	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
498217001793	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
498217001794	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
498217001795	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
498217001796	Uncharacterized conserved protein [Function unknown]; Region: COG3148
498217001797	thioredoxin 2; Provisional; Region: PRK10996
498217001798	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
498217001799	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
498217001800	catalytic residues [active]
498217001801	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
498217001802	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
498217001803	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
498217001804	two-component response regulator; Provisional; Region: PRK11173
498217001805	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217001806	active site
498217001807	phosphorylation site [posttranslational modification]
498217001808	intermolecular recognition site; other site
498217001809	dimerization interface [polypeptide binding]; other site
498217001810	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498217001811	DNA binding site [nucleotide binding]
498217001812	putative RNA methyltransferase; Provisional; Region: PRK10433
498217001813	RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050
498217001814	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
498217001815	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
498217001816	putative catalytic residues [active]
498217001817	putative nucleotide binding site [chemical binding]; other site
498217001818	putative aspartate binding site [chemical binding]; other site
498217001819	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
498217001820	dimer interface [polypeptide binding]; other site
498217001821	putative threonine allosteric regulatory site; other site
498217001822	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
498217001823	putative threonine allosteric regulatory site; other site
498217001824	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
498217001825	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
498217001826	homoserine kinase; Provisional; Region: PRK01212
498217001827	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
498217001828	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
498217001829	threonine synthase; Validated; Region: PRK09225
498217001830	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
498217001831	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
498217001832	catalytic residue [active]
498217001833	hypothetical protein; Validated; Region: PRK02101
498217001834	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
498217001835	amino acid carrier protein; Region: agcS; TIGR00835
498217001836	transaldolase-like protein; Provisional; Region: PTZ00411
498217001837	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
498217001838	active site
498217001839	dimer interface [polypeptide binding]; other site
498217001840	catalytic residue [active]
498217001841	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
498217001842	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
498217001843	tetramerization interface [polypeptide binding]; other site
498217001844	NAD(P) binding site [chemical binding]; other site
498217001845	catalytic residues [active]
498217001846	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
498217001847	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217001848	active site
498217001849	motif I; other site
498217001850	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
498217001851	MPT binding site; other site
498217001852	trimer interface [polypeptide binding]; other site
498217001853	metabolite-proton symporter; Region: 2A0106; TIGR00883
498217001854	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217001855	putative substrate translocation pore; other site
498217001856	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
498217001857	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
498217001858	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
498217001859	nucleotide binding site [chemical binding]; other site
498217001860	chaperone protein DnaJ; Provisional; Region: PRK10767
498217001861	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
498217001862	HSP70 interaction site [polypeptide binding]; other site
498217001863	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
498217001864	substrate binding site [polypeptide binding]; other site
498217001865	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
498217001866	Zn binding sites [ion binding]; other site
498217001867	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
498217001868	dimer interface [polypeptide binding]; other site
498217001869	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
498217001870	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
498217001871	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217001872	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
498217001873	putative dimerization interface [polypeptide binding]; other site
498217001874	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
498217001875	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
498217001876	active site
498217001877	Riboflavin kinase; Region: Flavokinase; smart00904
498217001878	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
498217001879	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
498217001880	active site
498217001881	HIGH motif; other site
498217001882	nucleotide binding site [chemical binding]; other site
498217001883	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
498217001884	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
498217001885	active site
498217001886	KMSKS motif; other site
498217001887	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
498217001888	tRNA binding surface [nucleotide binding]; other site
498217001889	anticodon binding site; other site
498217001890	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
498217001891	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
498217001892	lipoprotein signal peptidase; Provisional; Region: PRK14787
498217001893	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
498217001894	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
498217001895	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
498217001896	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
498217001897	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
498217001898	substrate binding site [chemical binding]; other site
498217001899	xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908
498217001900	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
498217001901	catalytic loop [active]
498217001902	iron binding site [ion binding]; other site
498217001903	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
498217001904	xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971
498217001905	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
498217001906	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
498217001907	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
498217001908	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
498217001909	dihydrodipicolinate reductase; Provisional; Region: PRK00048
498217001910	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
498217001911	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
498217001912	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
498217001913	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
498217001914	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
498217001915	catalytic site [active]
498217001916	subunit interface [polypeptide binding]; other site
498217001917	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
498217001918	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
498217001919	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
498217001920	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
498217001921	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
498217001922	ATP-grasp domain; Region: ATP-grasp_4; cl17255
498217001923	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
498217001924	IMP binding site; other site
498217001925	dimer interface [polypeptide binding]; other site
498217001926	interdomain contacts; other site
498217001927	partial ornithine binding site; other site
498217001928	Uncharacterized conserved protein [Function unknown]; Region: COG2966
498217001929	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
498217001930	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
498217001931	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
498217001932	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
498217001933	folate binding site [chemical binding]; other site
498217001934	NADP+ binding site [chemical binding]; other site
498217001935	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
498217001936	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
498217001937	active site
498217001938	metal binding site [ion binding]; metal-binding site
498217001939	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
498217001940	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
498217001941	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
498217001942	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
498217001943	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
498217001944	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
498217001945	SurA N-terminal domain; Region: SurA_N; pfam09312
498217001946	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
498217001947	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
498217001948	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
498217001949	OstA-like protein; Region: OstA; pfam03968
498217001950	Organic solvent tolerance protein; Region: OstA_C; pfam04453
498217001951	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
498217001952	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
498217001953	putative metal binding site [ion binding]; other site
498217001954	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
498217001955	HSP70 interaction site [polypeptide binding]; other site
498217001956	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
498217001957	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
498217001958	active site
498217001959	ATP-dependent helicase HepA; Validated; Region: PRK04914
498217001960	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498217001961	ATP binding site [chemical binding]; other site
498217001962	putative Mg++ binding site [ion binding]; other site
498217001963	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498217001964	nucleotide binding region [chemical binding]; other site
498217001965	ATP-binding site [chemical binding]; other site
498217001966	DNA polymerase II; Reviewed; Region: PRK05762
498217001967	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
498217001968	active site
498217001969	catalytic site [active]
498217001970	substrate binding site [chemical binding]; other site
498217001971	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
498217001972	active site
498217001973	metal-binding site
498217001974	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
498217001975	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217001976	Walker A/P-loop; other site
498217001977	ATP binding site [chemical binding]; other site
498217001978	Q-loop/lid; other site
498217001979	ABC transporter signature motif; other site
498217001980	Walker B; other site
498217001981	D-loop; other site
498217001982	H-loop/switch region; other site
498217001983	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
498217001984	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217001985	dimer interface [polypeptide binding]; other site
498217001986	conserved gate region; other site
498217001987	putative PBP binding loops; other site
498217001988	ABC-ATPase subunit interface; other site
498217001989	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
498217001990	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
498217001991	transcriptional regulator SgrR; Provisional; Region: PRK13626
498217001992	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
498217001993	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
498217001994	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
498217001995	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
498217001996	transmembrane helices; other site
498217001997	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
498217001998	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
498217001999	Walker A/P-loop; other site
498217002000	ATP binding site [chemical binding]; other site
498217002001	Q-loop/lid; other site
498217002002	ABC transporter signature motif; other site
498217002003	Walker B; other site
498217002004	D-loop; other site
498217002005	H-loop/switch region; other site
498217002006	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
498217002007	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
498217002008	Walker A/P-loop; other site
498217002009	ATP binding site [chemical binding]; other site
498217002010	Q-loop/lid; other site
498217002011	ABC transporter signature motif; other site
498217002012	Walker B; other site
498217002013	D-loop; other site
498217002014	H-loop/switch region; other site
498217002015	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
498217002016	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
498217002017	siderophore binding site; other site
498217002018	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
498217002019	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
498217002020	ABC-ATPase subunit  interface; other site
498217002021	dimer interface [polypeptide binding]; other site
498217002022	putative PBP binding regions; other site
498217002023	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
498217002024	ABC-ATPase subunit  interface; other site
498217002025	dimer interface [polypeptide binding]; other site
498217002026	putative PBP binding regions; other site
498217002027	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
498217002028	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
498217002029	N-terminal plug; other site
498217002030	ligand-binding site [chemical binding]; other site
498217002031	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
498217002032	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
498217002033	substrate binding site [chemical binding]; other site
498217002034	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
498217002035	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
498217002036	substrate binding site [chemical binding]; other site
498217002037	ligand binding site [chemical binding]; other site
498217002038	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
498217002039	tartrate dehydrogenase; Provisional; Region: PRK08194
498217002040	2-isopropylmalate synthase; Validated; Region: PRK00915
498217002041	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
498217002042	active site
498217002043	catalytic residues [active]
498217002044	metal binding site [ion binding]; metal-binding site
498217002045	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
498217002046	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
498217002047	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217002048	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
498217002049	putative substrate binding pocket [chemical binding]; other site
498217002050	putative dimerization interface [polypeptide binding]; other site
498217002051	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
498217002052	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
498217002053	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
498217002054	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
498217002055	acyl-activating enzyme (AAE) consensus motif; other site
498217002056	acyl-activating enzyme (AAE) consensus motif; other site
498217002057	putative AMP binding site [chemical binding]; other site
498217002058	putative active site [active]
498217002059	putative CoA binding site [chemical binding]; other site
498217002060	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
498217002061	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
498217002062	PYR/PP interface [polypeptide binding]; other site
498217002063	dimer interface [polypeptide binding]; other site
498217002064	TPP binding site [chemical binding]; other site
498217002065	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
498217002066	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
498217002067	TPP-binding site [chemical binding]; other site
498217002068	dimer interface [polypeptide binding]; other site
498217002069	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
498217002070	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
498217002071	putative valine binding site [chemical binding]; other site
498217002072	dimer interface [polypeptide binding]; other site
498217002073	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
498217002074	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
498217002075	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
498217002076	DNA binding site [nucleotide binding]
498217002077	domain linker motif; other site
498217002078	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
498217002079	dimerization interface [polypeptide binding]; other site
498217002080	ligand binding site [chemical binding]; other site
498217002081	MraZ protein; Region: MraZ; pfam02381
498217002082	MraZ protein; Region: MraZ; pfam02381
498217002083	MraW methylase family; Region: Methyltransf_5; pfam01795
498217002084	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
498217002085	cell division protein FtsL; Provisional; Region: PRK10772
498217002086	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
498217002087	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
498217002088	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
498217002089	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
498217002090	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
498217002091	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
498217002092	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
498217002093	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
498217002094	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
498217002095	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
498217002096	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
498217002097	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
498217002098	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
498217002099	Mg++ binding site [ion binding]; other site
498217002100	putative catalytic motif [active]
498217002101	putative substrate binding site [chemical binding]; other site
498217002102	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
498217002103	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
498217002104	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
498217002105	cell division protein FtsW; Provisional; Region: PRK10774
498217002106	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
498217002107	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
498217002108	active site
498217002109	homodimer interface [polypeptide binding]; other site
498217002110	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
498217002111	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
498217002112	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
498217002113	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
498217002114	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
498217002115	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
498217002116	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
498217002117	cell division protein FtsQ; Provisional; Region: PRK10775
498217002118	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
498217002119	Cell division protein FtsQ; Region: FtsQ; pfam03799
498217002120	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
498217002121	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
498217002122	Cell division protein FtsA; Region: FtsA; pfam14450
498217002123	cell division protein FtsZ; Validated; Region: PRK09330
498217002124	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
498217002125	nucleotide binding site [chemical binding]; other site
498217002126	SulA interaction site; other site
498217002127	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
498217002128	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
498217002129	Protein of unknown function (DUF721); Region: DUF721; cl02324
498217002130	SecA regulator SecM; Provisional; Region: PRK02943
498217002131	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
498217002132	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
498217002133	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
498217002134	nucleotide binding region [chemical binding]; other site
498217002135	ATP-binding site [chemical binding]; other site
498217002136	SEC-C motif; Region: SEC-C; pfam02810
498217002137	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
498217002138	active site
498217002139	8-oxo-dGMP binding site [chemical binding]; other site
498217002140	nudix motif; other site
498217002141	metal binding site [ion binding]; metal-binding site
498217002142	DNA gyrase inhibitor; Reviewed; Region: PRK00418
498217002143	hypothetical protein; Provisional; Region: PRK05287
498217002144	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
498217002145	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
498217002146	CoA-binding site [chemical binding]; other site
498217002147	ATP-binding [chemical binding]; other site
498217002148	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
498217002149	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
498217002150	active site
498217002151	type IV pilin biogenesis protein; Provisional; Region: PRK10573
498217002152	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
498217002153	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
498217002154	hypothetical protein; Provisional; Region: PRK10436
498217002155	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
498217002156	Walker A motif; other site
498217002157	ATP binding site [chemical binding]; other site
498217002158	Walker B motif; other site
498217002159	putative major pilin subunit; Provisional; Region: PRK10574
498217002160	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
498217002161	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
498217002162	amidase catalytic site [active]
498217002163	Zn binding residues [ion binding]; other site
498217002164	substrate binding site [chemical binding]; other site
498217002165	regulatory protein AmpE; Provisional; Region: PRK10987
498217002166	aromatic amino acid transporter; Provisional; Region: PRK10238
498217002167	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
498217002168	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498217002169	DNA-binding site [nucleotide binding]; DNA binding site
498217002170	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
498217002171	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
498217002172	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
498217002173	dimer interface [polypeptide binding]; other site
498217002174	TPP-binding site [chemical binding]; other site
498217002175	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
498217002176	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
498217002177	E3 interaction surface; other site
498217002178	lipoyl attachment site [posttranslational modification]; other site
498217002179	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
498217002180	E3 interaction surface; other site
498217002181	lipoyl attachment site [posttranslational modification]; other site
498217002182	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
498217002183	E3 interaction surface; other site
498217002184	lipoyl attachment site [posttranslational modification]; other site
498217002185	e3 binding domain; Region: E3_binding; pfam02817
498217002186	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
498217002187	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
498217002188	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
498217002189	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498217002190	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
498217002191	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
498217002192	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
498217002193	substrate binding site [chemical binding]; other site
498217002194	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
498217002195	substrate binding site [chemical binding]; other site
498217002196	ligand binding site [chemical binding]; other site
498217002197	Protein of unknown function (DUF533); Region: DUF533; pfam04391
498217002198	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
498217002199	putative metal binding site [ion binding]; other site
498217002200	hypothetical protein; Provisional; Region: PRK05248
498217002201	aromatic amino acid exporter; Provisional; Region: PRK11689
498217002202	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
498217002203	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498217002204	active site
498217002205	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
498217002206	active site clefts [active]
498217002207	zinc binding site [ion binding]; other site
498217002208	dimer interface [polypeptide binding]; other site
498217002209	DNA-binding response regulator CreB; Provisional; Region: PRK11083
498217002210	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217002211	active site
498217002212	phosphorylation site [posttranslational modification]
498217002213	intermolecular recognition site; other site
498217002214	dimerization interface [polypeptide binding]; other site
498217002215	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498217002216	DNA binding site [nucleotide binding]
498217002217	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
498217002218	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
498217002219	Walker A/P-loop; other site
498217002220	ATP binding site [chemical binding]; other site
498217002221	Q-loop/lid; other site
498217002222	ABC transporter signature motif; other site
498217002223	Walker B; other site
498217002224	D-loop; other site
498217002225	H-loop/switch region; other site
498217002226	inner membrane transport permease; Provisional; Region: PRK15066
498217002227	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
498217002228	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
498217002229	active site
498217002230	active pocket/dimerization site; other site
498217002231	phosphorylation site [posttranslational modification]
498217002232	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
498217002233	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
498217002234	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498217002235	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
498217002236	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
498217002237	dimer interface [polypeptide binding]; other site
498217002238	active site
498217002239	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
498217002240	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
498217002241	active site
498217002242	phosphorylation site [posttranslational modification]
498217002243	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
498217002244	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
498217002245	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
498217002246	putative active site [active]
498217002247	putative metal binding site [ion binding]; other site
498217002248	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
498217002249	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
498217002250	tetramerization interface [polypeptide binding]; other site
498217002251	active site
498217002252	pantoate--beta-alanine ligase; Region: panC; TIGR00018
498217002253	Pantoate-beta-alanine ligase; Region: PanC; cd00560
498217002254	active site
498217002255	ATP-binding site [chemical binding]; other site
498217002256	pantoate-binding site; other site
498217002257	HXXH motif; other site
498217002258	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
498217002259	oligomerization interface [polypeptide binding]; other site
498217002260	active site
498217002261	metal binding site [ion binding]; metal-binding site
498217002262	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
498217002263	catalytic center binding site [active]
498217002264	ATP binding site [chemical binding]; other site
498217002265	poly(A) polymerase I; Provisional; Region: pcnB; PRK11623
498217002266	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
498217002267	active site
498217002268	NTP binding site [chemical binding]; other site
498217002269	metal binding triad [ion binding]; metal-binding site
498217002270	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
498217002271	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
498217002272	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
498217002273	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
498217002274	active site
498217002275	nucleotide binding site [chemical binding]; other site
498217002276	HIGH motif; other site
498217002277	KMSKS motif; other site
498217002278	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
498217002279	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
498217002280	2'-5' RNA ligase; Provisional; Region: PRK15124
498217002281	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
498217002282	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
498217002283	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
498217002284	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498217002285	ATP binding site [chemical binding]; other site
498217002286	putative Mg++ binding site [ion binding]; other site
498217002287	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498217002288	nucleotide binding region [chemical binding]; other site
498217002289	ATP-binding site [chemical binding]; other site
498217002290	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
498217002291	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
498217002292	Transglycosylase; Region: Transgly; pfam00912
498217002293	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
498217002294	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
498217002295	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
498217002296	trimer interface [polypeptide binding]; other site
498217002297	eyelet of channel; other site
498217002298	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
498217002299	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
498217002300	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
498217002301	metal binding site [ion binding]; metal-binding site
498217002302	hypothetical protein; Provisional; Region: PRK10726
498217002303	FlxA-like protein; Region: FlxA; pfam14282
498217002304	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
498217002305	thymidylate synthase; Reviewed; Region: thyA; PRK01827
498217002306	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
498217002307	dimerization interface [polypeptide binding]; other site
498217002308	active site
498217002309	hypothetical protein; Provisional; Region: PRK10506
498217002310	hypothetical protein; Provisional; Region: PRK10557
498217002311	Protein of unknown function (DUF2509); Region: DUF2509; cl11672
498217002312	Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528
498217002313	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
498217002314	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
498217002315	protease3; Provisional; Region: PRK15101
498217002316	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
498217002317	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
498217002318	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
498217002319	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
498217002320	AAA domain; Region: AAA_30; pfam13604
498217002321	Family description; Region: UvrD_C_2; pfam13538
498217002322	N-acetylglutamate synthase; Validated; Region: PRK05279
498217002323	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
498217002324	putative feedback inhibition sensing region; other site
498217002325	putative nucleotide binding site [chemical binding]; other site
498217002326	putative substrate binding site [chemical binding]; other site
498217002327	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498217002328	Coenzyme A binding pocket [chemical binding]; other site
498217002329	AMIN domain; Region: AMIN; pfam11741
498217002330	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
498217002331	active site
498217002332	metal binding site [ion binding]; metal-binding site
498217002333	murein transglycosylase A; Provisional; Region: mltA; PRK11162
498217002334	MltA specific insert domain; Region: MltA; pfam03562
498217002335	3D domain; Region: 3D; pfam06725
498217002336	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
498217002337	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
498217002338	putative ATP binding site [chemical binding]; other site
498217002339	putative substrate interface [chemical binding]; other site
498217002340	Fe-S metabolism associated domain; Region: SufE; cl00951
498217002341	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
498217002342	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
498217002343	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
498217002344	catalytic residue [active]
498217002345	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
498217002346	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217002347	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
498217002348	dimerization interface [polypeptide binding]; other site
498217002349	substrate binding pocket [chemical binding]; other site
498217002350	hypothetical protein; Provisional; Region: PRK10873
498217002351	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
498217002352	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
498217002353	flap endonuclease-like protein; Provisional; Region: PRK09482
498217002354	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
498217002355	active site
498217002356	metal binding site 1 [ion binding]; metal-binding site
498217002357	putative 5' ssDNA interaction site; other site
498217002358	metal binding site 3; metal-binding site
498217002359	metal binding site 2 [ion binding]; metal-binding site
498217002360	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
498217002361	putative DNA binding site [nucleotide binding]; other site
498217002362	putative metal binding site [ion binding]; other site
498217002363	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
498217002364	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
498217002365	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
498217002366	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
498217002367	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
498217002368	SecY interacting protein Syd; Provisional; Region: PRK04968
498217002369	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
498217002370	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
498217002371	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
498217002372	probable active site [active]
498217002373	flavodoxin; Provisional; Region: PRK08105
498217002374	hypothetical protein; Provisional; Region: PRK13677
498217002375	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
498217002376	Domain of unknown function (DUF305); Region: DUF305; cl17794
498217002377	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
498217002378	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
498217002379	trimer interface [polypeptide binding]; other site
498217002380	active site
498217002381	substrate binding site [chemical binding]; other site
498217002382	CoA binding site [chemical binding]; other site
498217002383	PII uridylyl-transferase; Provisional; Region: PRK05007
498217002384	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
498217002385	metal binding triad; other site
498217002386	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
498217002387	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
498217002388	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
498217002389	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
498217002390	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
498217002391	active site
498217002392	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
498217002393	rRNA interaction site [nucleotide binding]; other site
498217002394	S8 interaction site; other site
498217002395	putative laminin-1 binding site; other site
498217002396	elongation factor Ts; Provisional; Region: tsf; PRK09377
498217002397	UBA/TS-N domain; Region: UBA; pfam00627
498217002398	Elongation factor TS; Region: EF_TS; pfam00889
498217002399	Elongation factor TS; Region: EF_TS; pfam00889
498217002400	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
498217002401	putative nucleotide binding site [chemical binding]; other site
498217002402	uridine monophosphate binding site [chemical binding]; other site
498217002403	homohexameric interface [polypeptide binding]; other site
498217002404	ribosome recycling factor; Reviewed; Region: frr; PRK00083
498217002405	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
498217002406	hinge region; other site
498217002407	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
498217002408	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
498217002409	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
498217002410	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
498217002411	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
498217002412	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
498217002413	catalytic residue [active]
498217002414	putative FPP diphosphate  binding site; other site
498217002415	putative FPP binding hydrophobic cleft; other site
498217002416	dimer interface [polypeptide binding]; other site
498217002417	putative IPP diphosphate binding site; other site
498217002418	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
498217002419	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
498217002420	zinc metallopeptidase RseP; Provisional; Region: PRK10779
498217002421	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
498217002422	active site
498217002423	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
498217002424	protein binding site [polypeptide binding]; other site
498217002425	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
498217002426	protein binding site [polypeptide binding]; other site
498217002427	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
498217002428	putative substrate binding region [chemical binding]; other site
498217002429	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
498217002430	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
498217002431	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
498217002432	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
498217002433	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
498217002434	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
498217002435	Surface antigen; Region: Bac_surface_Ag; pfam01103
498217002436	periplasmic chaperone; Provisional; Region: PRK10780
498217002437	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
498217002438	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
498217002439	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
498217002440	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
498217002441	trimer interface [polypeptide binding]; other site
498217002442	active site
498217002443	UDP-GlcNAc binding site [chemical binding]; other site
498217002444	lipid binding site [chemical binding]; lipid-binding site
498217002445	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
498217002446	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
498217002447	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
498217002448	active site
498217002449	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
498217002450	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
498217002451	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
498217002452	RNA/DNA hybrid binding site [nucleotide binding]; other site
498217002453	active site
498217002454	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
498217002455	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
498217002456	putative active site [active]
498217002457	putative PHP Thumb interface [polypeptide binding]; other site
498217002458	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
498217002459	generic binding surface II; other site
498217002460	generic binding surface I; other site
498217002461	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
498217002462	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
498217002463	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
498217002464	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
498217002465	putative metal binding site [ion binding]; other site
498217002466	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498217002467	DNA binding site [nucleotide binding]
498217002468	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
498217002469	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
498217002470	lysine decarboxylase CadA; Provisional; Region: PRK15400
498217002471	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
498217002472	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
498217002473	homodimer interface [polypeptide binding]; other site
498217002474	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217002475	catalytic residue [active]
498217002476	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
498217002477	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
498217002478	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217002479	putative substrate translocation pore; other site
498217002480	POT family; Region: PTR2; pfam00854
498217002481	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
498217002482	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
498217002483	Ligand Binding Site [chemical binding]; other site
498217002484	TilS substrate binding domain; Region: TilS; pfam09179
498217002485	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
498217002486	Cytochrome c553 [Energy production and conversion]; Region: COG2863
498217002487	Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210
498217002488	hypothetical protein; Provisional; Region: PRK04964
498217002489	YaeQ protein; Region: YaeQ; pfam07152
498217002490	hypothetical protein; Provisional; Region: PRK09256
498217002491	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
498217002492	NlpE N-terminal domain; Region: NlpE; pfam04170
498217002493	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
498217002494	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
498217002495	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
498217002496	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
498217002497	putative active site [active]
498217002498	hypothetical protein; Provisional; Region: PRK11590
498217002499	putative alcohol dehydrogenase; Provisional; Region: PRK09860
498217002500	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
498217002501	dimer interface [polypeptide binding]; other site
498217002502	active site
498217002503	metal binding site [ion binding]; metal-binding site
498217002504	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
498217002505	active site residue [active]
498217002506	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
498217002507	nucleoside/Zn binding site; other site
498217002508	dimer interface [polypeptide binding]; other site
498217002509	catalytic motif [active]
498217002510	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
498217002511	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498217002512	substrate binding pocket [chemical binding]; other site
498217002513	membrane-bound complex binding site; other site
498217002514	hinge residues; other site
498217002515	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
498217002516	N-acetyl-D-glucosamine binding site [chemical binding]; other site
498217002517	catalytic residue [active]
498217002518	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
498217002519	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
498217002520	dimerization interface [polypeptide binding]; other site
498217002521	ATP binding site [chemical binding]; other site
498217002522	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
498217002523	dimerization interface [polypeptide binding]; other site
498217002524	ATP binding site [chemical binding]; other site
498217002525	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
498217002526	putative active site [active]
498217002527	catalytic triad [active]
498217002528	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
498217002529	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217002530	dimer interface [polypeptide binding]; other site
498217002531	phosphorylation site [posttranslational modification]
498217002532	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217002533	Mg2+ binding site [ion binding]; other site
498217002534	G-X-G motif; other site
498217002535	hypothetical protein; Provisional; Region: PRK10722
498217002536	response regulator GlrR; Provisional; Region: PRK15115
498217002537	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217002538	active site
498217002539	phosphorylation site [posttranslational modification]
498217002540	intermolecular recognition site; other site
498217002541	dimerization interface [polypeptide binding]; other site
498217002542	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217002543	Walker A motif; other site
498217002544	ATP binding site [chemical binding]; other site
498217002545	Walker B motif; other site
498217002546	arginine finger; other site
498217002547	NAD synthetase; Provisional; Region: PRK13981
498217002548	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
498217002549	multimer interface [polypeptide binding]; other site
498217002550	active site
498217002551	catalytic triad [active]
498217002552	protein interface 1 [polypeptide binding]; other site
498217002553	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
498217002554	homodimer interface [polypeptide binding]; other site
498217002555	NAD binding pocket [chemical binding]; other site
498217002556	ATP binding pocket [chemical binding]; other site
498217002557	Mg binding site [ion binding]; other site
498217002558	active-site loop [active]
498217002559	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
498217002560	Nitrogen regulatory protein P-II; Region: P-II; smart00938
498217002561	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
498217002562	active site
498217002563	dimer interface [polypeptide binding]; other site
498217002564	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
498217002565	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
498217002566	putative active site [active]
498217002567	putative dimer interface [polypeptide binding]; other site
498217002568	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
498217002569	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
498217002570	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
498217002571	ApbE family; Region: ApbE; pfam02424
498217002572	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
498217002573	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
498217002574	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
498217002575	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
498217002576	catalytic residue [active]
498217002577	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
498217002578	active site
498217002579	DNA polymerase IV; Validated; Region: PRK02406
498217002580	DNA binding site [nucleotide binding]
498217002581	peptidase T; Region: peptidase-T; TIGR01882
498217002582	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
498217002583	metal binding site [ion binding]; metal-binding site
498217002584	dimer interface [polypeptide binding]; other site
498217002585	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
498217002586	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322
498217002587	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
498217002588	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
498217002589	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
498217002590	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
498217002591	metal binding site [ion binding]; metal-binding site
498217002592	dimer interface [polypeptide binding]; other site
498217002593	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498217002594	active site
498217002595	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
498217002596	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
498217002597	gamma-glutamyl kinase; Provisional; Region: PRK05429
498217002598	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
498217002599	nucleotide binding site [chemical binding]; other site
498217002600	homotetrameric interface [polypeptide binding]; other site
498217002601	putative phosphate binding site [ion binding]; other site
498217002602	putative allosteric binding site; other site
498217002603	PUA domain; Region: PUA; pfam01472
498217002604	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
498217002605	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
498217002606	putative catalytic cysteine [active]
498217002607	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
498217002608	Prostaglandin dehydrogenases; Region: PGDH; cd05288
498217002609	NAD(P) binding site [chemical binding]; other site
498217002610	substrate binding site [chemical binding]; other site
498217002611	dimer interface [polypeptide binding]; other site
498217002612	integrase; Provisional; Region: PRK09692
498217002613	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
498217002614	active site
498217002615	Int/Topo IB signature motif; other site
498217002616	AAA domain; Region: AAA_21; pfam13304
498217002617	Phage polarity suppression protein (Psu); Region: Psu; pfam07455
498217002618	recombination associated protein; Reviewed; Region: rdgC; PRK00321
498217002619	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
498217002620	transposase/IS protein; Provisional; Region: PRK09183
498217002621	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217002622	Walker A motif; other site
498217002623	ATP binding site [chemical binding]; other site
498217002624	Walker B motif; other site
498217002625	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
498217002626	Helix-turn-helix domain; Region: HTH_38; pfam13936
498217002627	Integrase core domain; Region: rve; pfam00665
498217002628	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
498217002629	Transposase; Region: DEDD_Tnp_IS110; pfam01548
498217002630	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
498217002631	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
498217002632	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
498217002633	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
498217002634	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
498217002635	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
498217002636	haemagglutination activity domain; Region: Haemagg_act; pfam05860
498217002637	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
498217002638	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
498217002639	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
498217002640	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
498217002641	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
498217002642	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
498217002643	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
498217002644	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
498217002645	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
498217002646	dimer interface [polypeptide binding]; other site
498217002647	active site
498217002648	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
498217002649	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
498217002650	NAD(P) binding site [chemical binding]; other site
498217002651	active site
498217002652	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
498217002653	putative active site 1 [active]
498217002654	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
498217002655	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
498217002656	dimer interface [polypeptide binding]; other site
498217002657	active site
498217002658	Protein of unknown function (DUF3261); Region: DUF3261; pfam11659
498217002659	Predicted exporter [General function prediction only]; Region: COG4258
498217002660	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
498217002661	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
498217002662	active site
498217002663	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
498217002664	Ligand binding site; other site
498217002665	Putative Catalytic site; other site
498217002666	DXD motif; other site
498217002667	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
498217002668	putative acyl-acceptor binding pocket; other site
498217002669	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
498217002670	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
498217002671	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
498217002672	acyl-activating enzyme (AAE) consensus motif; other site
498217002673	AMP binding site [chemical binding]; other site
498217002674	active site
498217002675	CoA binding site [chemical binding]; other site
498217002676	Predicted membrane protein [Function unknown]; Region: COG4648
498217002677	acyl carrier protein; Provisional; Region: PRK05350
498217002678	Phosphopantetheine attachment site; Region: PP-binding; cl09936
498217002679	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
498217002680	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
498217002681	putative acyl-acceptor binding pocket; other site
498217002682	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
498217002683	Methyltransferase domain; Region: Methyltransf_18; pfam12847
498217002684	S-adenosylmethionine binding site [chemical binding]; other site
498217002685	tryptophan permease TnaB; Provisional; Region: PRK09664
498217002686	aromatic amino acid transport protein; Region: araaP; TIGR00837
498217002687	tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617
498217002688	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
498217002689	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
498217002690	catalytic residue [active]
498217002691	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
498217002692	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217002693	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
498217002694	dimerization interface [polypeptide binding]; other site
498217002695	substrate binding pocket [chemical binding]; other site
498217002696	permease DsdX; Provisional; Region: PRK09921
498217002697	gluconate transporter; Region: gntP; TIGR00791
498217002698	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
498217002699	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
498217002700	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
498217002701	catalytic residue [active]
498217002702	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
498217002703	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
498217002704	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
498217002705	Moco binding site; other site
498217002706	metal coordination site [ion binding]; other site
498217002707	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
498217002708	guanine deaminase; Region: guan_deamin; TIGR02967
498217002709	active site
498217002710	type III secretion system protein SsaL; Provisional; Region: PRK15345
498217002711	HrpJ-like domain; Region: HrpJ; pfam07201
498217002712	Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327
498217002713	type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544
498217002714	Type III secretion needle MxiH like; Region: MxiH; pfam09392
498217002715	Protein of unknown function (DUF1039); Region: DUF1039; cl05668
498217002716	Type III secretion needle MxiH like; Region: MxiH; cl09641
498217002717	Helix-turn-helix domain; Region: HTH_18; pfam12833
498217002718	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
498217002719	Protein of unknown function (DUF1895); Region: DUF1895; cl07553
498217002720	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
498217002721	type III secretion system protein SsaD; Provisional; Region: PRK15367
498217002722	outer membrane secretin SsaC; Provisional; Region: PRK15346
498217002723	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
498217002724	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
498217002725	pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357
498217002726	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
498217002727	Tetratricopeptide repeat; Region: TPR_3; pfam07720
498217002728	pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360
498217002729	pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361
498217002730	pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362
498217002731	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
498217002732	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
498217002733	binding surface
498217002734	TPR motif; other site
498217002735	EspA-like secreted protein; Region: EspA; pfam03433
498217002736	hypothetical protein; Provisional; Region: PRK11820
498217002737	type III secretion system protein SsaQ; Validated; Region: PRK08035
498217002738	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
498217002739	Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157
498217002740	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
498217002741	Walker A motif; other site
498217002742	ATP binding site [chemical binding]; other site
498217002743	Walker B motif; other site
498217002744	secretion system apparatus protein SsaV; Provisional; Region: PRK12720
498217002745	FHIPEP family; Region: FHIPEP; pfam00771
498217002746	type III secretion system protein SsaM; Provisional; Region: PRK15353
498217002747	type III secretion system protein YscR; Provisional; Region: PRK12797
498217002748	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
498217002749	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
498217002750	secretion system apparatus protein SsaU; Reviewed; Region: PRK12721
498217002751	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
498217002752	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
498217002753	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
498217002754	N-acetyl-D-glucosamine binding site [chemical binding]; other site
498217002755	catalytic residue [active]
498217002756	two component system sensor kinase SsrA; Provisional; Region: PRK15347
498217002757	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217002758	dimer interface [polypeptide binding]; other site
498217002759	phosphorylation site [posttranslational modification]
498217002760	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217002761	ATP binding site [chemical binding]; other site
498217002762	Mg2+ binding site [ion binding]; other site
498217002763	G-X-G motif; other site
498217002764	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217002765	active site
498217002766	phosphorylation site [posttranslational modification]
498217002767	intermolecular recognition site; other site
498217002768	dimerization interface [polypeptide binding]; other site
498217002769	Hpt domain; Region: Hpt; pfam01627
498217002770	putative binding surface; other site
498217002771	active site
498217002772	two component system sensor kinase SsrB; Provisional; Region: PRK15369
498217002773	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217002774	active site
498217002775	phosphorylation site [posttranslational modification]
498217002776	intermolecular recognition site; other site
498217002777	dimerization interface [polypeptide binding]; other site
498217002778	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
498217002779	DNA binding residues [nucleotide binding]
498217002780	dimerization interface [polypeptide binding]; other site
498217002781	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
498217002782	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
498217002783	dimer interface [polypeptide binding]; other site
498217002784	active site
498217002785	heme binding site [chemical binding]; other site
498217002786	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
498217002787	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
498217002788	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217002789	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
498217002790	dimerization interface [polypeptide binding]; other site
498217002791	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
498217002792	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
498217002793	tetramer interface [polypeptide binding]; other site
498217002794	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217002795	catalytic residue [active]
498217002796	threonine/serine transporter TdcC; Provisional; Region: PRK13629
498217002797	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
498217002798	propionate/acetate kinase; Provisional; Region: PRK12379
498217002799	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
498217002800	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
498217002801	Pyruvate formate lyase 1; Region: PFL1; cd01678
498217002802	coenzyme A binding site [chemical binding]; other site
498217002803	active site
498217002804	catalytic residues [active]
498217002805	glycine loop; other site
498217002806	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
498217002807	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
498217002808	dimer interface [polypeptide binding]; other site
498217002809	active site
498217002810	metal binding site [ion binding]; metal-binding site
498217002811	Accessory colonization factor AcfC, contains ABC-type periplasmic domain [General function prediction only]; Region: AcfC; COG4588
498217002812	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
498217002813	conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731
498217002814	Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818
498217002815	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
498217002816	active site
498217002817	metal binding site [ion binding]; metal-binding site
498217002818	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
498217002819	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
498217002820	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217002821	dimer interface [polypeptide binding]; other site
498217002822	putative PBP binding loops; other site
498217002823	ABC-ATPase subunit interface; other site
498217002824	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217002825	dimer interface [polypeptide binding]; other site
498217002826	conserved gate region; other site
498217002827	putative PBP binding loops; other site
498217002828	ABC-ATPase subunit interface; other site
498217002829	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
498217002830	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
498217002831	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
498217002832	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217002833	Walker A/P-loop; other site
498217002834	ATP binding site [chemical binding]; other site
498217002835	Q-loop/lid; other site
498217002836	ABC transporter signature motif; other site
498217002837	Walker B; other site
498217002838	D-loop; other site
498217002839	H-loop/switch region; other site
498217002840	TOBE domain; Region: TOBE_2; pfam08402
498217002841	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
498217002842	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
498217002843	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
498217002844	haemagglutination activity domain; Region: Haemagg_act; pfam05860
498217002845	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
498217002846	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
498217002847	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
498217002848	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
498217002849	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
498217002850	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
498217002851	D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397
498217002852	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
498217002853	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
498217002854	putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983
498217002855	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
498217002856	dimer interface [polypeptide binding]; other site
498217002857	active site
498217002858	glycine loop; other site
498217002859	pyruvate formate lyase II activase; Provisional; Region: PRK10076
498217002860	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
498217002861	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
498217002862	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
498217002863	dimer interface [polypeptide binding]; other site
498217002864	FMN binding site [chemical binding]; other site
498217002865	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
498217002866	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
498217002867	putative active site [active]
498217002868	cell density-dependent motility repressor; Provisional; Region: PRK10082
498217002869	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217002870	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
498217002871	dimerization interface [polypeptide binding]; other site
498217002872	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
498217002873	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
498217002874	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
498217002875	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
498217002876	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
498217002877	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
498217002878	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217002879	putative PBP binding loops; other site
498217002880	ABC-ATPase subunit interface; other site
498217002881	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
498217002882	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217002883	ATP binding site [chemical binding]; other site
498217002884	Q-loop/lid; other site
498217002885	ABC transporter signature motif; other site
498217002886	Walker B; other site
498217002887	D-loop; other site
498217002888	H-loop/switch region; other site
498217002889	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
498217002890	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
498217002891	Class I aldolases; Region: Aldolase_Class_I; cl17187
498217002892	catalytic residue [active]
498217002893	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
498217002894	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
498217002895	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
498217002896	putative active site [active]
498217002897	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
498217002898	Na binding site [ion binding]; other site
498217002899	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
498217002900	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
498217002901	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
498217002902	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
498217002903	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
498217002904	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
498217002905	HlyD family secretion protein; Region: HlyD_3; pfam13437
498217002906	Fusaric acid resistance protein family; Region: FUSC; pfam04632
498217002907	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
498217002908	dUMP phosphatase; Provisional; Region: PRK09449
498217002909	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217002910	motif II; other site
498217002911	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
498217002912	molybdenum-pterin binding domain; Region: Mop; TIGR00638
498217002913	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
498217002914	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
498217002915	putative chaperone; Provisional; Region: PRK11678
498217002916	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
498217002917	nucleotide binding site [chemical binding]; other site
498217002918	putative NEF/HSP70 interaction site [polypeptide binding]; other site
498217002919	SBD interface [polypeptide binding]; other site
498217002920	PAS domain S-box; Region: sensory_box; TIGR00229
498217002921	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
498217002922	putative active site [active]
498217002923	heme pocket [chemical binding]; other site
498217002924	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
498217002925	PAS domain; Region: PAS_9; pfam13426
498217002926	putative active site [active]
498217002927	heme pocket [chemical binding]; other site
498217002928	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
498217002929	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
498217002930	metal binding site [ion binding]; metal-binding site
498217002931	active site
498217002932	I-site; other site
498217002933	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
498217002934	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
498217002935	MgtE intracellular N domain; Region: MgtE_N; pfam03448
498217002936	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
498217002937	Protein of unknown function (DUF2633); Region: DUF2633; pfam11119
498217002938	MASE1; Region: MASE1; cl17823
498217002939	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
498217002940	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
498217002941	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
498217002942	putative proline-specific permease; Provisional; Region: proY; PRK10580
498217002943	Spore germination protein; Region: Spore_permease; cl17796
498217002944	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
498217002945	Mechanosensitive ion channel; Region: MS_channel; pfam00924
498217002946	maltodextrin glucosidase; Provisional; Region: PRK10785
498217002947	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
498217002948	homodimer interface [polypeptide binding]; other site
498217002949	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
498217002950	active site
498217002951	homodimer interface [polypeptide binding]; other site
498217002952	catalytic site [active]
498217002953	peroxidase; Provisional; Region: PRK15000
498217002954	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
498217002955	dimer interface [polypeptide binding]; other site
498217002956	decamer (pentamer of dimers) interface [polypeptide binding]; other site
498217002957	catalytic triad [active]
498217002958	peroxidatic and resolving cysteines [active]
498217002959	Protein of unknown function, DUF479; Region: DUF479; cl01203
498217002960	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
498217002961	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
498217002962	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
498217002963	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
498217002964	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
498217002965	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
498217002966	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
498217002967	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
498217002968	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
498217002969	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
498217002970	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
498217002971	Protein export membrane protein; Region: SecD_SecF; pfam02355
498217002972	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217002973	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
498217002974	Walker A motif; other site
498217002975	ATP binding site [chemical binding]; other site
498217002976	Walker B motif; other site
498217002977	arginine finger; other site
498217002978	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
498217002979	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
498217002980	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217002981	putative substrate translocation pore; other site
498217002982	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217002983	EthD domain; Region: EthD; cl17553
498217002984	EthD domain; Region: EthD; cl17553
498217002985	EthD domain; Region: EthD; cl17553
498217002986	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
498217002987	classical (c) SDRs; Region: SDR_c; cd05233
498217002988	NAD(P) binding site [chemical binding]; other site
498217002989	active site
498217002990	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
498217002991	classical (c) SDRs; Region: SDR_c; cd05233
498217002992	NAD(P) binding site [chemical binding]; other site
498217002993	active site
498217002994	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
498217002995	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
498217002996	active site
498217002997	FMN binding site [chemical binding]; other site
498217002998	substrate binding site [chemical binding]; other site
498217002999	putative catalytic residue [active]
498217003000	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
498217003001	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498217003002	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
498217003003	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
498217003004	active site
498217003005	FMN binding site [chemical binding]; other site
498217003006	substrate binding site [chemical binding]; other site
498217003007	putative catalytic residue [active]
498217003008	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
498217003009	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498217003010	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
498217003011	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
498217003012	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498217003013	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217003014	homodimer interface [polypeptide binding]; other site
498217003015	catalytic residue [active]
498217003016	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
498217003017	ATP cone domain; Region: ATP-cone; pfam03477
498217003018	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
498217003019	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
498217003020	catalytic motif [active]
498217003021	Zn binding site [ion binding]; other site
498217003022	RibD C-terminal domain; Region: RibD_C; cl17279
498217003023	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
498217003024	homopentamer interface [polypeptide binding]; other site
498217003025	active site
498217003026	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
498217003027	putative RNA binding site [nucleotide binding]; other site
498217003028	thiamine monophosphate kinase; Provisional; Region: PRK05731
498217003029	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
498217003030	ATP binding site [chemical binding]; other site
498217003031	dimerization interface [polypeptide binding]; other site
498217003032	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
498217003033	tetramer interfaces [polypeptide binding]; other site
498217003034	binuclear metal-binding site [ion binding]; other site
498217003035	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
498217003036	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
498217003037	TPP-binding site; other site
498217003038	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
498217003039	PYR/PP interface [polypeptide binding]; other site
498217003040	dimer interface [polypeptide binding]; other site
498217003041	TPP binding site [chemical binding]; other site
498217003042	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
498217003043	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
498217003044	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
498217003045	substrate binding pocket [chemical binding]; other site
498217003046	chain length determination region; other site
498217003047	substrate-Mg2+ binding site; other site
498217003048	catalytic residues [active]
498217003049	aspartate-rich region 1; other site
498217003050	active site lid residues [active]
498217003051	aspartate-rich region 2; other site
498217003052	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
498217003053	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
498217003054	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
498217003055	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
498217003056	Ligand Binding Site [chemical binding]; other site
498217003057	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
498217003058	active site residue [active]
498217003059	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
498217003060	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
498217003061	conserved cys residue [active]
498217003062	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
498217003063	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
498217003064	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
498217003065	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
498217003066	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
498217003067	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217003068	Major Facilitator Superfamily; Region: MFS_1; pfam07690
498217003069	putative substrate translocation pore; other site
498217003070	muropeptide transporter; Reviewed; Region: ampG; PRK11902
498217003071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217003072	putative substrate translocation pore; other site
498217003073	hypothetical protein; Provisional; Region: PRK11627
498217003074	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
498217003075	transcriptional regulator BolA; Provisional; Region: PRK11628
498217003076	trigger factor; Provisional; Region: tig; PRK01490
498217003077	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
498217003078	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
498217003079	Clp protease; Region: CLP_protease; pfam00574
498217003080	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
498217003081	oligomer interface [polypeptide binding]; other site
498217003082	active site residues [active]
498217003083	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
498217003084	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
498217003085	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217003086	Walker A motif; other site
498217003087	ATP binding site [chemical binding]; other site
498217003088	Walker B motif; other site
498217003089	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
498217003090	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
498217003091	Found in ATP-dependent protease La (LON); Region: LON; smart00464
498217003092	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217003093	Walker A motif; other site
498217003094	ATP binding site [chemical binding]; other site
498217003095	Walker B motif; other site
498217003096	arginine finger; other site
498217003097	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
498217003098	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
498217003099	IHF dimer interface [polypeptide binding]; other site
498217003100	IHF - DNA interface [nucleotide binding]; other site
498217003101	periplasmic folding chaperone; Provisional; Region: PRK10788
498217003102	SurA N-terminal domain; Region: SurA_N_3; cl07813
498217003103	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
498217003104	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
498217003105	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
498217003106	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
498217003107	Ligand Binding Site [chemical binding]; other site
498217003108	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
498217003109	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
498217003110	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
498217003111	thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126
498217003112	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
498217003113	active site
498217003114	motif I; other site
498217003115	motif II; other site
498217003116	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
498217003117	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
498217003118	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
498217003119	putative DNA binding site [nucleotide binding]; other site
498217003120	putative Zn2+ binding site [ion binding]; other site
498217003121	AsnC family; Region: AsnC_trans_reg; pfam01037
498217003122	Nitrogen regulatory protein P-II; Region: P-II; cl00412
498217003123	Nitrogen regulatory protein P-II; Region: P-II; smart00938
498217003124	ammonium transporter; Provisional; Region: PRK10666
498217003125	acyl-CoA thioesterase II; Provisional; Region: PRK10526
498217003126	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
498217003127	active site
498217003128	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
498217003129	catalytic triad [active]
498217003130	dimer interface [polypeptide binding]; other site
498217003131	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
498217003132	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
498217003133	DNA binding site [nucleotide binding]
498217003134	active site
498217003135	gene expression modulator; Provisional; Region: PRK10945
498217003136	Hha toxicity attenuator; Provisional; Region: PRK10667
498217003137	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
498217003138	Protein export membrane protein; Region: SecD_SecF; cl14618
498217003139	Protein export membrane protein; Region: SecD_SecF; cl14618
498217003140	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
498217003141	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
498217003142	HlyD family secretion protein; Region: HlyD_3; pfam13437
498217003143	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
498217003144	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498217003145	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
498217003146	DsrE/DsrF-like family; Region: DrsE; cl00672
498217003147	hypothetical protein; Provisional; Region: PRK11281
498217003148	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
498217003149	Mechanosensitive ion channel; Region: MS_channel; pfam00924
498217003150	hypothetical protein; Provisional; Region: PRK11038
498217003151	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
498217003152	Primosomal replication protein priB and priC; Region: priB_priC; cl11483
498217003153	hypothetical protein; Provisional; Region: PRK10527
498217003154	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498217003155	active site
498217003156	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
498217003157	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217003158	Walker A motif; other site
498217003159	ATP binding site [chemical binding]; other site
498217003160	Walker B motif; other site
498217003161	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
498217003162	arginine finger; other site
498217003163	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
498217003164	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
498217003165	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
498217003166	hypothetical protein; Validated; Region: PRK00153
498217003167	recombination protein RecR; Reviewed; Region: recR; PRK00076
498217003168	RecR protein; Region: RecR; pfam02132
498217003169	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
498217003170	putative active site [active]
498217003171	putative metal-binding site [ion binding]; other site
498217003172	tetramer interface [polypeptide binding]; other site
498217003173	heat shock protein 90; Provisional; Region: PRK05218
498217003174	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217003175	ATP binding site [chemical binding]; other site
498217003176	Mg2+ binding site [ion binding]; other site
498217003177	G-X-G motif; other site
498217003178	adenylate kinase; Reviewed; Region: adk; PRK00279
498217003179	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
498217003180	AMP-binding site [chemical binding]; other site
498217003181	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
498217003182	ferrochelatase; Reviewed; Region: hemH; PRK00035
498217003183	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
498217003184	C-terminal domain interface [polypeptide binding]; other site
498217003185	active site
498217003186	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
498217003187	active site
498217003188	N-terminal domain interface [polypeptide binding]; other site
498217003189	inosine/guanosine kinase; Provisional; Region: PRK15074
498217003190	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
498217003191	substrate binding site [chemical binding]; other site
498217003192	ATP binding site [chemical binding]; other site
498217003193	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
498217003194	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
498217003195	fimbrial assembly chaperone SthB; Provisional; Region: PRK15295
498217003196	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
498217003197	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
498217003198	PapC N-terminal domain; Region: PapC_N; pfam13954
498217003199	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
498217003200	PapC C-terminal domain; Region: PapC_C; pfam13953
498217003201	Fimbrial protein; Region: Fimbrial; pfam00419
498217003202	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
498217003203	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
498217003204	active site
498217003205	metal binding site [ion binding]; metal-binding site
498217003206	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
498217003207	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
498217003208	putative deacylase active site [active]
498217003209	fructuronate transporter; Provisional; Region: PRK10034
498217003210	gluconate transporter; Region: gntP; TIGR00791
498217003211	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
498217003212	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498217003213	DNA-binding site [nucleotide binding]; DNA binding site
498217003214	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
498217003215	TraB family; Region: TraB; cl12050
498217003216	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
498217003217	metal-binding site [ion binding]
498217003218	copper exporting ATPase; Provisional; Region: copA; PRK10671
498217003219	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
498217003220	metal-binding site [ion binding]
498217003221	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
498217003222	metal-binding site [ion binding]
498217003223	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
498217003224	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217003225	motif II; other site
498217003226	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
498217003227	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
498217003228	DNA binding residues [nucleotide binding]
498217003229	dimer interface [polypeptide binding]; other site
498217003230	copper binding site [ion binding]; other site
498217003231	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
498217003232	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
498217003233	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
498217003234	HutD; Region: HutD; pfam05962
498217003235	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
498217003236	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
498217003237	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
498217003238	MFS_1 like family; Region: MFS_1_like; pfam12832
498217003239	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
498217003240	active site
498217003241	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
498217003242	active site
498217003243	D-lactate dehydrogenase; Provisional; Region: PRK11183
498217003244	FAD binding domain; Region: FAD_binding_4; pfam01565
498217003245	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
498217003246	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
498217003247	dimerization interface [polypeptide binding]; other site
498217003248	putative DNA binding site [nucleotide binding]; other site
498217003249	putative Zn2+ binding site [ion binding]; other site
498217003250	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
498217003251	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498217003252	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
498217003253	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
498217003254	active site residue [active]
498217003255	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
498217003256	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217003257	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
498217003258	putative dimerization interface [polypeptide binding]; other site
498217003259	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
498217003260	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
498217003261	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
498217003262	tetramer interface [polypeptide binding]; other site
498217003263	active site
498217003264	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
498217003265	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
498217003266	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
498217003267	catalytic residue [active]
498217003268	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
498217003269	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
498217003270	active site
498217003271	homotetramer interface [polypeptide binding]; other site
498217003272	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
498217003273	substrate binding site [chemical binding]; other site
498217003274	multimerization interface [polypeptide binding]; other site
498217003275	ATP binding site [chemical binding]; other site
498217003276	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
498217003277	dimer interface [polypeptide binding]; other site
498217003278	substrate binding site [chemical binding]; other site
498217003279	ATP binding site [chemical binding]; other site
498217003280	Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816
498217003281	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
498217003282	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
498217003283	catalytic residues [active]
498217003284	hinge region; other site
498217003285	alpha helical domain; other site
498217003286	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
498217003287	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217003288	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
498217003289	putative protease; Provisional; Region: PRK15452
498217003290	Peptidase family U32; Region: Peptidase_U32; pfam01136
498217003291	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
498217003292	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
498217003293	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
498217003294	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217003295	active site
498217003296	phosphorylation site [posttranslational modification]
498217003297	intermolecular recognition site; other site
498217003298	dimerization interface [polypeptide binding]; other site
498217003299	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498217003300	DNA binding site [nucleotide binding]
498217003301	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
498217003302	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
498217003303	dimerization interface [polypeptide binding]; other site
498217003304	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217003305	dimer interface [polypeptide binding]; other site
498217003306	phosphorylation site [posttranslational modification]
498217003307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217003308	ATP binding site [chemical binding]; other site
498217003309	Mg2+ binding site [ion binding]; other site
498217003310	G-X-G motif; other site
498217003311	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
498217003312	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
498217003313	Protein export membrane protein; Region: SecD_SecF; cl14618
498217003314	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
498217003315	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
498217003316	HlyD family secretion protein; Region: HlyD_3; pfam13437
498217003317	hypothetical protein; Provisional; Region: PRK10579
498217003318	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683
498217003319	nudix motif; other site
498217003320	recombination associated protein; Reviewed; Region: rdgC; PRK00321
498217003321	fructokinase; Reviewed; Region: PRK09557
498217003322	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
498217003323	nucleotide binding site [chemical binding]; other site
498217003324	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
498217003325	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
498217003326	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217003327	AAA domain; Region: AAA_23; pfam13476
498217003328	Walker A/P-loop; other site
498217003329	ATP binding site [chemical binding]; other site
498217003330	Q-loop/lid; other site
498217003331	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217003332	ABC transporter signature motif; other site
498217003333	Walker B; other site
498217003334	D-loop; other site
498217003335	H-loop/switch region; other site
498217003336	exonuclease subunit SbcD; Provisional; Region: PRK10966
498217003337	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
498217003338	active site
498217003339	metal binding site [ion binding]; metal-binding site
498217003340	DNA binding site [nucleotide binding]
498217003341	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
498217003342	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
498217003343	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217003344	active site
498217003345	phosphorylation site [posttranslational modification]
498217003346	intermolecular recognition site; other site
498217003347	dimerization interface [polypeptide binding]; other site
498217003348	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498217003349	DNA binding site [nucleotide binding]
498217003350	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
498217003351	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
498217003352	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
498217003353	putative active site [active]
498217003354	heme pocket [chemical binding]; other site
498217003355	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217003356	dimer interface [polypeptide binding]; other site
498217003357	phosphorylation site [posttranslational modification]
498217003358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217003359	ATP binding site [chemical binding]; other site
498217003360	Mg2+ binding site [ion binding]; other site
498217003361	G-X-G motif; other site
498217003362	exopolyphosphatase; Provisional; Region: PRK10854
498217003363	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
498217003364	nucleotide binding site [chemical binding]; other site
498217003365	polyphosphate kinase; Provisional; Region: PRK05443
498217003366	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
498217003367	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
498217003368	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
498217003369	putative active site [active]
498217003370	catalytic site [active]
498217003371	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
498217003372	putative active site [active]
498217003373	catalytic site [active]
498217003374	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
498217003375	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498217003376	Coenzyme A binding pocket [chemical binding]; other site
498217003377	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
498217003378	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
498217003379	active site
498217003380	substrate binding site [chemical binding]; other site
498217003381	cosubstrate binding site; other site
498217003382	catalytic site [active]
498217003383	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
498217003384	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
498217003385	dimerization interface [polypeptide binding]; other site
498217003386	putative ATP binding site [chemical binding]; other site
498217003387	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498217003388	active site
498217003389	uracil transporter; Provisional; Region: PRK10720
498217003390	DoxX; Region: DoxX; pfam07681
498217003391	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
498217003392	DNA replication initiation factor; Provisional; Region: PRK08084
498217003393	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
498217003394	ArsC family; Region: ArsC; pfam03960
498217003395	catalytic residues [active]
498217003396	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
498217003397	Peptidase family M48; Region: Peptidase_M48; pfam01435
498217003398	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
498217003399	Domain of unknown function DUF20; Region: UPF0118; pfam01594
498217003400	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
498217003401	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
498217003402	catalytic triad [active]
498217003403	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
498217003404	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
498217003405	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
498217003406	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
498217003407	dihydrodipicolinate synthase; Region: dapA; TIGR00674
498217003408	dimer interface [polypeptide binding]; other site
498217003409	active site
498217003410	catalytic residue [active]
498217003411	lipoprotein; Provisional; Region: PRK11679
498217003412	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
498217003413	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
498217003414	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
498217003415	ATP binding site [chemical binding]; other site
498217003416	active site
498217003417	substrate binding site [chemical binding]; other site
498217003418	Putative cyclase; Region: Cyclase; cl00814
498217003419	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
498217003420	amphipathic channel; other site
498217003421	Asn-Pro-Ala signature motifs; other site
498217003422	hypothetical protein; Provisional; Region: PRK06489
498217003423	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
498217003424	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
498217003425	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
498217003426	Helicase; Region: Helicase_RecD; pfam05127
498217003427	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
498217003428	putative hydrolase; Provisional; Region: PRK11460
498217003429	Predicted esterase [General function prediction only]; Region: COG0400
498217003430	Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980
498217003431	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
498217003432	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
498217003433	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
498217003434	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
498217003435	metal binding site [ion binding]; metal-binding site
498217003436	dimer interface [polypeptide binding]; other site
498217003437	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
498217003438	ArsC family; Region: ArsC; pfam03960
498217003439	putative catalytic residues [active]
498217003440	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
498217003441	Protein export membrane protein; Region: SecD_SecF; cl14618
498217003442	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547
498217003443	transcriptional regulator NarP; Provisional; Region: PRK10403
498217003444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217003445	active site
498217003446	phosphorylation site [posttranslational modification]
498217003447	intermolecular recognition site; other site
498217003448	dimerization interface [polypeptide binding]; other site
498217003449	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
498217003450	DNA binding residues [nucleotide binding]
498217003451	dimerization interface [polypeptide binding]; other site
498217003452	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
498217003453	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
498217003454	HAMP domain; Region: HAMP; pfam00672
498217003455	dimerization interface [polypeptide binding]; other site
498217003456	Histidine kinase; Region: HisKA_3; pfam07730
498217003457	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217003458	ATP binding site [chemical binding]; other site
498217003459	Mg2+ binding site [ion binding]; other site
498217003460	G-X-G motif; other site
498217003461	ferredoxin-type protein; Provisional; Region: PRK10194
498217003462	assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553
498217003463	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
498217003464	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
498217003465	[4Fe-4S] binding site [ion binding]; other site
498217003466	molybdopterin cofactor binding site; other site
498217003467	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
498217003468	molybdopterin cofactor binding site; other site
498217003469	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
498217003470	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
498217003471	4Fe-4S binding domain; Region: Fer4_5; pfam12801
498217003472	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
498217003473	nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586
498217003474	cytochrome c-type protein NapC; Provisional; Region: PRK10617
498217003475	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
498217003476	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
498217003477	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
498217003478	dimer interface [polypeptide binding]; other site
498217003479	ADP-ribose binding site [chemical binding]; other site
498217003480	active site
498217003481	nudix motif; other site
498217003482	metal binding site [ion binding]; metal-binding site
498217003483	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
498217003484	Malic enzyme, N-terminal domain; Region: malic; pfam00390
498217003485	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
498217003486	putative NAD(P) binding site [chemical binding]; other site
498217003487	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
498217003488	Protein of unknown function, DUF399; Region: DUF399; pfam04187
498217003489	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
498217003490	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
498217003491	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
498217003492	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
498217003493	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
498217003494	active site
498217003495	metal binding site [ion binding]; metal-binding site
498217003496	putative acetyltransferase; Provisional; Region: PRK03624
498217003497	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498217003498	Coenzyme A binding pocket [chemical binding]; other site
498217003499	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
498217003500	Protein of unknown function (DUF1131); Region: DUF1131; pfam06572
498217003501	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
498217003502	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
498217003503	HPr interaction site; other site
498217003504	glycerol kinase (GK) interaction site [polypeptide binding]; other site
498217003505	active site
498217003506	phosphorylation site [posttranslational modification]
498217003507	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
498217003508	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
498217003509	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
498217003510	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
498217003511	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
498217003512	dimerization domain swap beta strand [polypeptide binding]; other site
498217003513	regulatory protein interface [polypeptide binding]; other site
498217003514	active site
498217003515	regulatory phosphorylation site [posttranslational modification]; other site
498217003516	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
498217003517	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
498217003518	dimer interface [polypeptide binding]; other site
498217003519	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217003520	catalytic residue [active]
498217003521	putative sulfate transport protein CysZ; Validated; Region: PRK04949
498217003522	cell division protein ZipA; Provisional; Region: PRK03427
498217003523	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
498217003524	FtsZ protein binding site [polypeptide binding]; other site
498217003525	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
498217003526	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
498217003527	nucleotide binding pocket [chemical binding]; other site
498217003528	K-X-D-G motif; other site
498217003529	catalytic site [active]
498217003530	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
498217003531	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
498217003532	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
498217003533	Dimer interface [polypeptide binding]; other site
498217003534	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
498217003535	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
498217003536	active site
498217003537	HIGH motif; other site
498217003538	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
498217003539	active site
498217003540	KMSKS motif; other site
498217003541	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
498217003542	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
498217003543	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
498217003544	Nucleoside recognition; Region: Gate; pfam07670
498217003545	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
498217003546	manganese transport protein MntH; Reviewed; Region: PRK00701
498217003547	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
498217003548	glucokinase; Provisional; Region: glk; PRK00292
498217003549	glucokinase, proteobacterial type; Region: glk; TIGR00749
498217003550	secY/secA suppressor protein; Provisional; Region: PRK11467
498217003551	DsrE/DsrF-like family; Region: DrsE; cl00672
498217003552	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
498217003553	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
498217003554	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
498217003555	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
498217003556	Ligand binding site; other site
498217003557	DXD motif; other site
498217003558	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
498217003559	aspartate racemase; Region: asp_race; TIGR00035
498217003560	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
498217003561	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
498217003562	ATP binding site [chemical binding]; other site
498217003563	substrate interface [chemical binding]; other site
498217003564	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
498217003565	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
498217003566	dimer interface [polypeptide binding]; other site
498217003567	putative functional site; other site
498217003568	putative MPT binding site; other site
498217003569	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
498217003570	active site
498217003571	hypothetical protein; Provisional; Region: PRK10835
498217003572	Predicted membrane protein [Function unknown]; Region: COG2311
498217003573	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
498217003574	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
498217003575	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
498217003576	putative active site [active]
498217003577	malate dehydrogenase; Provisional; Region: PRK13529
498217003578	Malic enzyme, N-terminal domain; Region: malic; pfam00390
498217003579	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
498217003580	NAD(P) binding site [chemical binding]; other site
498217003581	cytidine deaminase; Provisional; Region: PRK09027
498217003582	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
498217003583	active site
498217003584	catalytic motif [active]
498217003585	Zn binding site [ion binding]; other site
498217003586	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
498217003587	active site
498217003588	catalytic motif [active]
498217003589	Zn binding site [ion binding]; other site
498217003590	hypothetical protein; Provisional; Region: PRK10711
498217003591	hypothetical protein; Provisional; Region: PRK01821
498217003592	Predicted permeases [General function prediction only]; Region: RarD; COG2962
498217003593	exonuclease I; Provisional; Region: sbcB; PRK11779
498217003594	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
498217003595	active site
498217003596	catalytic site [active]
498217003597	substrate binding site [chemical binding]; other site
498217003598	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
498217003599	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
498217003600	Integrase core domain; Region: rve_3; pfam13683
498217003601	Predicted membrane protein [Function unknown]; Region: COG1289
498217003602	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
498217003603	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
498217003604	DEAD_2; Region: DEAD_2; pfam06733
498217003605	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
498217003606	LPS O-antigen length regulator; Provisional; Region: PRK10381
498217003607	Chain length determinant protein; Region: Wzz; cl15801
498217003608	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
498217003609	active site
498217003610	transketolase; Reviewed; Region: PRK12753
498217003611	endonuclease IV; Provisional; Region: PRK01060
498217003612	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
498217003613	AP (apurinic/apyrimidinic) site pocket; other site
498217003614	DNA interaction; other site
498217003615	Metal-binding active site; metal-binding site
498217003616	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
498217003617	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
498217003618	Ligand Binding Site [chemical binding]; other site
498217003619	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
498217003620	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217003621	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
498217003622	putative dimerization interface [polypeptide binding]; other site
498217003623	lysine transporter; Provisional; Region: PRK10836
498217003624	Peptidase M16C associated; Region: M16C_assoc; pfam08367
498217003625	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
498217003626	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
498217003627	active site
498217003628	HIGH motif; other site
498217003629	KMSKS motif; other site
498217003630	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
498217003631	tRNA binding surface [nucleotide binding]; other site
498217003632	anticodon binding site; other site
498217003633	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
498217003634	dimer interface [polypeptide binding]; other site
498217003635	putative tRNA-binding site [nucleotide binding]; other site
498217003636	antiporter inner membrane protein; Provisional; Region: PRK11670
498217003637	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
498217003638	Walker A motif; other site
498217003639	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
498217003640	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
498217003641	ATP-binding site [chemical binding]; other site
498217003642	Sugar specificity; other site
498217003643	Pyrimidine base specificity; other site
498217003644	EamA-like transporter family; Region: EamA; pfam00892
498217003645	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
498217003646	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
498217003647	trimer interface [polypeptide binding]; other site
498217003648	active site
498217003649	putative assembly protein; Provisional; Region: PRK10833
498217003650	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
498217003651	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
498217003652	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
498217003653	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
498217003654	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
498217003655	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
498217003656	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
498217003657	active site
498217003658	O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296
498217003659	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
498217003660	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
498217003661	active site
498217003662	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
498217003663	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498217003664	putative ADP-binding pocket [chemical binding]; other site
498217003665	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498217003666	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
498217003667	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498217003668	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
498217003669	putative ADP-binding pocket [chemical binding]; other site
498217003670	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
498217003671	active site
498217003672	tetramer interface; other site
498217003673	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
498217003674	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
498217003675	NAD binding site [chemical binding]; other site
498217003676	homodimer interface [polypeptide binding]; other site
498217003677	active site
498217003678	substrate binding site [chemical binding]; other site
498217003679	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
498217003680	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
498217003681	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
498217003682	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
498217003683	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
498217003684	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
498217003685	putative NAD(P) binding site [chemical binding]; other site
498217003686	active site
498217003687	putative substrate binding site [chemical binding]; other site
498217003688	Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922
498217003689	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
498217003690	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
498217003691	putative trimer interface [polypeptide binding]; other site
498217003692	putative CoA binding site [chemical binding]; other site
498217003693	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
498217003694	NeuB family; Region: NeuB; pfam03102
498217003695	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
498217003696	NeuB binding interface [polypeptide binding]; other site
498217003697	putative substrate binding site [chemical binding]; other site
498217003698	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
498217003699	ligand binding site; other site
498217003700	tetramer interface; other site
498217003701	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
498217003702	active site
498217003703	catalytic triad [active]
498217003704	oxyanion hole [active]
498217003705	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
498217003706	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
498217003707	active site
498217003708	homodimer interface [polypeptide binding]; other site
498217003709	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
498217003710	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
498217003711	Beta-1,4-N-acetylgalactosaminyltransferase (CgtA); Region: CgtA; pfam06306
498217003712	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
498217003713	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
498217003714	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
498217003715	hypothetical protein; Provisional; Region: PRK05423
498217003716	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
498217003717	transposase/IS protein; Provisional; Region: PRK09183
498217003718	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217003719	Walker A motif; other site
498217003720	ATP binding site [chemical binding]; other site
498217003721	Walker B motif; other site
498217003722	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
498217003723	Helix-turn-helix domain; Region: HTH_38; pfam13936
498217003724	Integrase core domain; Region: rve; pfam00665
498217003725	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
498217003726	putative metal dependent hydrolase; Provisional; Region: PRK11598
498217003727	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
498217003728	Sulfatase; Region: Sulfatase; pfam00884
498217003729	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468
498217003730	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
498217003731	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
498217003732	FHIPEP family; Region: FHIPEP; pfam00771
498217003733	Flagellar protein FlhE; Region: FlhE; pfam06366
498217003734	FlgN protein; Region: FlgN; cl09176
498217003735	anti-sigma28 factor FlgM; Provisional; Region: PRK10810
498217003736	SAF-like; Region: SAF_2; pfam13144
498217003737	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
498217003738	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
498217003739	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
498217003740	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
498217003741	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
498217003742	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
498217003743	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
498217003744	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
498217003745	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
498217003746	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
498217003747	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
498217003748	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
498217003749	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
498217003750	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
498217003751	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
498217003752	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
498217003753	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
498217003754	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
498217003755	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
498217003756	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
498217003757	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
498217003758	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
498217003759	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
498217003760	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
498217003761	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
498217003762	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
498217003763	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147
498217003764	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
498217003765	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
498217003766	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027
498217003767	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
498217003768	Predicted membrane protein [Function unknown]; Region: COG3059
498217003769	Isochorismatase family; Region: Isochorismatase; pfam00857
498217003770	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
498217003771	catalytic triad [active]
498217003772	conserved cis-peptide bond; other site
498217003773	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
498217003774	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498217003775	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217003776	homodimer interface [polypeptide binding]; other site
498217003777	catalytic residue [active]
498217003778	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
498217003779	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
498217003780	trimer interface [polypeptide binding]; other site
498217003781	eyelet of channel; other site
498217003782	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
498217003783	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
498217003784	putative dimer interface [polypeptide binding]; other site
498217003785	putative anticodon binding site; other site
498217003786	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
498217003787	homodimer interface [polypeptide binding]; other site
498217003788	motif 1; other site
498217003789	motif 2; other site
498217003790	active site
498217003791	motif 3; other site
498217003792	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
498217003793	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
498217003794	active site
498217003795	aminopeptidase N; Provisional; Region: pepN; PRK14015
498217003796	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
498217003797	active site
498217003798	Zn binding site [ion binding]; other site
498217003799	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
498217003800	dimer interface [polypeptide binding]; other site
498217003801	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
498217003802	metal binding site [ion binding]; metal-binding site
498217003803	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
498217003804	catalytic site [active]
498217003805	BNR repeat-like domain; Region: BNR_2; pfam13088
498217003806	Asp-box motif; other site
498217003807	Autotransporter beta-domain; Region: Autotransporter; smart00869
498217003808	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
498217003809	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
498217003810	quinone interaction residues [chemical binding]; other site
498217003811	active site
498217003812	catalytic residues [active]
498217003813	FMN binding site [chemical binding]; other site
498217003814	substrate binding site [chemical binding]; other site
498217003815	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
498217003816	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
498217003817	PapC N-terminal domain; Region: PapC_N; pfam13954
498217003818	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
498217003819	PapC C-terminal domain; Region: PapC_C; pfam13953
498217003820	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
498217003821	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
498217003822	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
498217003823	Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012
498217003824	Ion channel; Region: Ion_trans_2; pfam07885
498217003825	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
498217003826	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
498217003827	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
498217003828	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217003829	S-adenosylmethionine binding site [chemical binding]; other site
498217003830	ABC transporter ATPase component; Reviewed; Region: PRK11147
498217003831	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217003832	Walker A/P-loop; other site
498217003833	ATP binding site [chemical binding]; other site
498217003834	Q-loop/lid; other site
498217003835	ABC transporter signature motif; other site
498217003836	Walker B; other site
498217003837	D-loop; other site
498217003838	H-loop/switch region; other site
498217003839	ABC transporter; Region: ABC_tran_2; pfam12848
498217003840	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498217003841	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
498217003842	Paraquat-inducible protein A; Region: PqiA; pfam04403
498217003843	Paraquat-inducible protein A; Region: PqiA; pfam04403
498217003844	paraquat-inducible protein B; Provisional; Region: PRK10807
498217003845	mce related protein; Region: MCE; pfam02470
498217003846	mce related protein; Region: MCE; pfam02470
498217003847	mce related protein; Region: MCE; pfam02470
498217003848	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
498217003849	Protein of unknown function (DUF330); Region: DUF330; pfam03886
498217003850	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
498217003851	active site 1 [active]
498217003852	dimer interface [polypeptide binding]; other site
498217003853	active site 2 [active]
498217003854	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
498217003855	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
498217003856	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
498217003857	outer membrane protein A; Reviewed; Region: PRK10808
498217003858	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
498217003859	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
498217003860	ligand binding site [chemical binding]; other site
498217003861	SOS cell division inhibitor; Provisional; Region: PRK10595
498217003862	TfoX N-terminal domain; Region: TfoX_N; pfam04993
498217003863	TfoX C-terminal domain; Region: TfoX_C; pfam04994
498217003864	TIGR01666 family membrane protein; Region: YCCS
498217003865	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
498217003866	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
498217003867	Predicted membrane protein [Function unknown]; Region: COG3304
498217003868	Domain of unknown function (DUF307); Region: DUF307; pfam03733
498217003869	Domain of unknown function (DUF307); Region: DUF307; pfam03733
498217003870	DNA helicase IV; Provisional; Region: helD; PRK11054
498217003871	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
498217003872	Part of AAA domain; Region: AAA_19; pfam13245
498217003873	Family description; Region: UvrD_C_2; pfam13538
498217003874	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
498217003875	active site
498217003876	dimer interfaces [polypeptide binding]; other site
498217003877	catalytic residues [active]
498217003878	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437
498217003879	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
498217003880	heat shock protein HspQ; Provisional; Region: PRK14129
498217003881	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
498217003882	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
498217003883	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
498217003884	putative RNA binding site [nucleotide binding]; other site
498217003885	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217003886	S-adenosylmethionine binding site [chemical binding]; other site
498217003887	acylphosphatase; Provisional; Region: PRK14426
498217003888	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
498217003889	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
498217003890	HflBKC-binding inner membrane protein; Provisional; Region: PRK10447
498217003891	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
498217003892	potential protein location (hypothetical protein ETAE_1283 [Edwardsiella tarda EIB202]) that overlaps RNA (tRNA-S)
498217003893	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
498217003894	active site
498217003895	catalytic triad [active]
498217003896	oxyanion hole [active]
498217003897	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498217003898	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217003899	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
498217003900	dimerization interface [polypeptide binding]; other site
498217003901	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
498217003902	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
498217003903	active site
498217003904	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
498217003905	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217003906	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
498217003907	putative substrate translocation pore; other site
498217003908	palmytilated EEV membrane glycoprotein; Provisional; Region: PHA03003
498217003909	Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106
498217003910	putative active site [active]
498217003911	putative catalytic site [active]
498217003912	Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107
498217003913	putative active site [active]
498217003914	putative catalytic site [active]
498217003915	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
498217003916	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
498217003917	inhibitor-cofactor binding pocket; inhibition site
498217003918	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217003919	catalytic residue [active]
498217003920	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
498217003921	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
498217003922	Ligand binding site; other site
498217003923	Putative Catalytic site; other site
498217003924	DXD motif; other site
498217003925	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
498217003926	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
498217003927	active site
498217003928	substrate binding site [chemical binding]; other site
498217003929	cosubstrate binding site; other site
498217003930	catalytic site [active]
498217003931	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
498217003932	active site
498217003933	hexamer interface [polypeptide binding]; other site
498217003934	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
498217003935	NAD binding site [chemical binding]; other site
498217003936	substrate binding site [chemical binding]; other site
498217003937	active site
498217003938	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
498217003939	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
498217003940	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
498217003941	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
498217003942	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
498217003943	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
498217003944	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
498217003945	trimer interface [polypeptide binding]; other site
498217003946	active site
498217003947	substrate binding site [chemical binding]; other site
498217003948	CoA binding site [chemical binding]; other site
498217003949	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
498217003950	DNA-binding site [nucleotide binding]; DNA binding site
498217003951	RNA-binding motif; other site
498217003952	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
498217003953	DNA-binding site [nucleotide binding]; DNA binding site
498217003954	RNA-binding motif; other site
498217003955	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
498217003956	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
498217003957	Domain of unknown function (DUF333); Region: DUF333; pfam03891
498217003958	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
498217003959	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
498217003960	catalytic core [active]
498217003961	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
498217003962	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
498217003963	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
498217003964	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217003965	active site
498217003966	phosphorylation site [posttranslational modification]
498217003967	intermolecular recognition site; other site
498217003968	dimerization interface [polypeptide binding]; other site
498217003969	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217003970	Walker A motif; other site
498217003971	ATP binding site [chemical binding]; other site
498217003972	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
498217003973	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
498217003974	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
498217003975	dimerization interface [polypeptide binding]; other site
498217003976	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217003977	dimer interface [polypeptide binding]; other site
498217003978	phosphorylation site [posttranslational modification]
498217003979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217003980	ATP binding site [chemical binding]; other site
498217003981	Mg2+ binding site [ion binding]; other site
498217003982	G-X-G motif; other site
498217003983	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
498217003984	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
498217003985	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
498217003986	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217003987	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217003988	Isochorismatase family; Region: Isochorismatase; pfam00857
498217003989	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
498217003990	catalytic triad [active]
498217003991	conserved cis-peptide bond; other site
498217003992	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
498217003993	Sulfatase; Region: Sulfatase; pfam00884
498217003994	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
498217003995	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
498217003996	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
498217003997	ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432
498217003998	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
498217003999	Walker A/P-loop; other site
498217004000	ATP binding site [chemical binding]; other site
498217004001	Q-loop/lid; other site
498217004002	ABC transporter signature motif; other site
498217004003	Walker B; other site
498217004004	D-loop; other site
498217004005	H-loop/switch region; other site
498217004006	TOBE domain; Region: TOBE_2; pfam08402
498217004007	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
498217004008	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217004009	dimer interface [polypeptide binding]; other site
498217004010	conserved gate region; other site
498217004011	putative PBP binding loops; other site
498217004012	ABC-ATPase subunit interface; other site
498217004013	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217004014	dimer interface [polypeptide binding]; other site
498217004015	conserved gate region; other site
498217004016	putative PBP binding loops; other site
498217004017	ABC-ATPase subunit interface; other site
498217004018	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
498217004019	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
498217004020	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217004021	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
498217004022	putative substrate translocation pore; other site
498217004023	Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851
498217004024	MASE1; Region: MASE1; pfam05231
498217004025	Histidine kinase; Region: HisKA_3; pfam07730
498217004026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217004027	ATP binding site [chemical binding]; other site
498217004028	Mg2+ binding site [ion binding]; other site
498217004029	G-X-G motif; other site
498217004030	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
498217004031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217004032	active site
498217004033	phosphorylation site [posttranslational modification]
498217004034	intermolecular recognition site; other site
498217004035	dimerization interface [polypeptide binding]; other site
498217004036	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
498217004037	DNA binding residues [nucleotide binding]
498217004038	dimerization interface [polypeptide binding]; other site
498217004039	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
498217004040	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
498217004041	dimerization interface [polypeptide binding]; other site
498217004042	DNA binding residues [nucleotide binding]
498217004043	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
498217004044	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
498217004045	dimer interface [polypeptide binding]; other site
498217004046	active site
498217004047	metal binding site [ion binding]; metal-binding site
498217004048	transcriptional activator FlhD; Provisional; Region: PRK02909
498217004049	transcriptional activator FlhC; Provisional; Region: PRK12722
498217004050	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
498217004051	flagellar motor protein MotA; Validated; Region: PRK09110
498217004052	flagellar motor protein MotB; Validated; Region: motB; PRK09041
498217004053	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
498217004054	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
498217004055	ligand binding site [chemical binding]; other site
498217004056	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
498217004057	putative binding surface; other site
498217004058	active site
498217004059	CheY binding; Region: CheY-binding; pfam09078
498217004060	chemotaxis protein CheA; Provisional; Region: PRK10547
498217004061	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
498217004062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217004063	ATP binding site [chemical binding]; other site
498217004064	Mg2+ binding site [ion binding]; other site
498217004065	G-X-G motif; other site
498217004066	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
498217004067	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
498217004068	putative CheA interaction surface; other site
498217004069	methyl-accepting protein IV; Provisional; Region: PRK09793
498217004070	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
498217004071	dimer interface [polypeptide binding]; other site
498217004072	ligand binding site [chemical binding]; other site
498217004073	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
498217004074	dimerization interface [polypeptide binding]; other site
498217004075	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
498217004076	dimer interface [polypeptide binding]; other site
498217004077	putative CheW interface [polypeptide binding]; other site
498217004078	methyl-accepting protein IV; Provisional; Region: PRK09793
498217004079	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
498217004080	dimer interface [polypeptide binding]; other site
498217004081	ligand binding site [chemical binding]; other site
498217004082	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
498217004083	dimerization interface [polypeptide binding]; other site
498217004084	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
498217004085	dimer interface [polypeptide binding]; other site
498217004086	putative CheW interface [polypeptide binding]; other site
498217004087	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
498217004088	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
498217004089	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217004090	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
498217004091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217004092	active site
498217004093	phosphorylation site [posttranslational modification]
498217004094	intermolecular recognition site; other site
498217004095	dimerization interface [polypeptide binding]; other site
498217004096	CheB methylesterase; Region: CheB_methylest; pfam01339
498217004097	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
498217004098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217004099	active site
498217004100	phosphorylation site [posttranslational modification]
498217004101	intermolecular recognition site; other site
498217004102	dimerization interface [polypeptide binding]; other site
498217004103	chemotaxis regulator CheZ; Provisional; Region: PRK11166
498217004104	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
498217004105	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
498217004106	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
498217004107	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
498217004108	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
498217004109	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
498217004110	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
498217004111	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
498217004112	putative metal binding site [ion binding]; other site
498217004113	dimer interface [polypeptide binding]; other site
498217004114	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
498217004115	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
498217004116	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217004117	The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418
498217004118	putative substrate binding pocket [chemical binding]; other site
498217004119	putative dimerization interface [polypeptide binding]; other site
498217004120	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
498217004121	active site
498217004122	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
498217004123	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
498217004124	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
498217004125	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
498217004126	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
498217004127	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
498217004128	isoaspartyl dipeptidase; Provisional; Region: PRK10657
498217004129	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
498217004130	active site
498217004131	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498217004132	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217004133	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
498217004134	dimerization interface [polypeptide binding]; other site
498217004135	Uncharacterized conserved protein [Function unknown]; Region: COG0398
498217004136	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
498217004137	mercuric reductase; Validated; Region: PRK06370
498217004138	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
498217004139	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498217004140	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
498217004141	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
498217004142	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
498217004143	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
498217004144	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
498217004145	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
498217004146	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
498217004147	tetramer interface [polypeptide binding]; other site
498217004148	heme binding pocket [chemical binding]; other site
498217004149	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122
498217004150	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
498217004151	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
498217004152	ATP binding site [chemical binding]; other site
498217004153	Mg++ binding site [ion binding]; other site
498217004154	motif III; other site
498217004155	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498217004156	nucleotide binding region [chemical binding]; other site
498217004157	ATP-binding site [chemical binding]; other site
498217004158	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
498217004159	putative RNA binding site [nucleotide binding]; other site
498217004160	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
498217004161	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498217004162	Coenzyme A binding pocket [chemical binding]; other site
498217004163	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
498217004164	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
498217004165	nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419
498217004166	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
498217004167	Walker A/P-loop; other site
498217004168	ATP binding site [chemical binding]; other site
498217004169	Q-loop/lid; other site
498217004170	ABC transporter signature motif; other site
498217004171	Walker B; other site
498217004172	D-loop; other site
498217004173	H-loop/switch region; other site
498217004174	nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418
498217004175	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
498217004176	Walker A/P-loop; other site
498217004177	ATP binding site [chemical binding]; other site
498217004178	Q-loop/lid; other site
498217004179	ABC transporter signature motif; other site
498217004180	Walker B; other site
498217004181	D-loop; other site
498217004182	H-loop/switch region; other site
498217004183	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
498217004184	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
498217004185	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217004186	dimer interface [polypeptide binding]; other site
498217004187	conserved gate region; other site
498217004188	putative PBP binding loops; other site
498217004189	ABC-ATPase subunit interface; other site
498217004190	nickel transporter permease NikB; Provisional; Region: PRK10352
498217004191	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217004192	dimer interface [polypeptide binding]; other site
498217004193	conserved gate region; other site
498217004194	putative PBP binding loops; other site
498217004195	ABC-ATPase subunit interface; other site
498217004196	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
498217004197	substrate binding site [chemical binding]; other site
498217004198	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
498217004199	transcriptional regulator NanR; Provisional; Region: PRK03837
498217004200	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498217004201	DNA-binding site [nucleotide binding]; DNA binding site
498217004202	FCD domain; Region: FCD; pfam07729
498217004203	N-acetylneuraminate lyase; Provisional; Region: PRK04147
498217004204	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
498217004205	inhibitor site; inhibition site
498217004206	active site
498217004207	dimer interface [polypeptide binding]; other site
498217004208	catalytic residue [active]
498217004209	putative sialic acid transporter; Provisional; Region: PRK03893
498217004210	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217004211	putative substrate translocation pore; other site
498217004212	N-acetylmannosamine kinase; Provisional; Region: PRK05082
498217004213	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
498217004214	nucleotide binding site [chemical binding]; other site
498217004215	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
498217004216	transcriptional regulator BetI; Validated; Region: PRK00767
498217004217	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498217004218	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
498217004219	putative transposase OrfB; Reviewed; Region: PHA02517
498217004220	HTH-like domain; Region: HTH_21; pfam13276
498217004221	Integrase core domain; Region: rve; pfam00665
498217004222	Integrase core domain; Region: rve_3; pfam13683
498217004223	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
498217004224	Transposase; Region: HTH_Tnp_1; pfam01527
498217004225	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
498217004226	Helix-turn-helix domain; Region: HTH_38; pfam13936
498217004227	Integrase core domain; Region: rve; pfam00665
498217004228	transposase/IS protein; Provisional; Region: PRK09183
498217004229	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217004230	Walker A motif; other site
498217004231	ATP binding site [chemical binding]; other site
498217004232	Walker B motif; other site
498217004233	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137
498217004234	integrase; Provisional; Region: PRK09692
498217004235	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
498217004236	active site
498217004237	Int/Topo IB signature motif; other site
498217004238	GTP-binding protein YchF; Reviewed; Region: PRK09601
498217004239	YchF GTPase; Region: YchF; cd01900
498217004240	G1 box; other site
498217004241	GTP/Mg2+ binding site [chemical binding]; other site
498217004242	Switch I region; other site
498217004243	G2 box; other site
498217004244	Switch II region; other site
498217004245	G3 box; other site
498217004246	G4 box; other site
498217004247	G5 box; other site
498217004248	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
498217004249	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
498217004250	putative active site [active]
498217004251	catalytic residue [active]
498217004252	hypothetical protein; Provisional; Region: PRK10692
498217004253	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
498217004254	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
498217004255	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498217004256	active site
498217004257	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
498217004258	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
498217004259	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
498217004260	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
498217004261	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
498217004262	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
498217004263	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
498217004264	tRNA; other site
498217004265	putative tRNA binding site [nucleotide binding]; other site
498217004266	putative NADP binding site [chemical binding]; other site
498217004267	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
498217004268	peptide chain release factor 1; Validated; Region: prfA; PRK00591
498217004269	This domain is found in peptide chain release factors; Region: PCRF; smart00937
498217004270	RF-1 domain; Region: RF-1; pfam00472
498217004271	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
498217004272	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217004273	hypothetical protein; Provisional; Region: PRK10941
498217004274	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
498217004275	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
498217004276	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
498217004277	putative transporter; Provisional; Region: PRK11660
498217004278	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
498217004279	Sulfate transporter family; Region: Sulfate_transp; pfam00916
498217004280	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
498217004281	hypothetical protein; Provisional; Region: PRK02487
498217004282	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
498217004283	hypothetical protein; Provisional; Region: PRK11622
498217004284	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
498217004285	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217004286	POT family; Region: PTR2; cl17359
498217004287	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
498217004288	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
498217004289	putative ligand binding site [chemical binding]; other site
498217004290	NAD binding site [chemical binding]; other site
498217004291	dimerization interface [polypeptide binding]; other site
498217004292	catalytic site [active]
498217004293	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
498217004294	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
498217004295	metal binding site [ion binding]; metal-binding site
498217004296	active site
498217004297	I-site; other site
498217004298	putative hydrolase; Validated; Region: PRK09248
498217004299	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
498217004300	active site
498217004301	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
498217004302	lipoprotein; Provisional; Region: PRK10598
498217004303	multidrug resistance protein MdtH; Provisional; Region: PRK11646
498217004304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217004305	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
498217004306	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
498217004307	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132
498217004308	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
498217004309	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
498217004310	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
498217004311	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
498217004312	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
498217004313	active site
498217004314	HIGH motif; other site
498217004315	KMSK motif region; other site
498217004316	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
498217004317	tRNA binding surface [nucleotide binding]; other site
498217004318	anticodon binding site; other site
498217004319	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
498217004320	putative metal binding site [ion binding]; other site
498217004321	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
498217004322	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498217004323	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217004324	homodimer interface [polypeptide binding]; other site
498217004325	catalytic residue [active]
498217004326	copper homeostasis protein CutC; Provisional; Region: PRK11572
498217004327	Methyltransferase domain; Region: Methyltransf_23; pfam13489
498217004328	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217004329	S-adenosylmethionine binding site [chemical binding]; other site
498217004330	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217004331	S-adenosylmethionine binding site [chemical binding]; other site
498217004332	phenylalanine transporter; Provisional; Region: PRK10249
498217004333	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
498217004334	hypothetical protein; Provisional; Region: PRK10302
498217004335	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
498217004336	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
498217004337	dimer interface [polypeptide binding]; other site
498217004338	anticodon binding site; other site
498217004339	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
498217004340	homodimer interface [polypeptide binding]; other site
498217004341	motif 1; other site
498217004342	active site
498217004343	motif 2; other site
498217004344	GAD domain; Region: GAD; pfam02938
498217004345	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
498217004346	active site
498217004347	motif 3; other site
498217004348	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
498217004349	nudix motif; other site
498217004350	hypothetical protein; Validated; Region: PRK00110
498217004351	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
498217004352	active site
498217004353	putative DNA-binding cleft [nucleotide binding]; other site
498217004354	dimer interface [polypeptide binding]; other site
498217004355	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
498217004356	RuvA N terminal domain; Region: RuvA_N; pfam01330
498217004357	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
498217004358	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217004359	Walker A motif; other site
498217004360	ATP binding site [chemical binding]; other site
498217004361	Walker B motif; other site
498217004362	arginine finger; other site
498217004363	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
498217004364	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
498217004365	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
498217004366	ABC-ATPase subunit  interface; other site
498217004367	dimer interface [polypeptide binding]; other site
498217004368	putative PBP binding regions; other site
498217004369	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
498217004370	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
498217004371	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
498217004372	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
498217004373	metal binding site [ion binding]; metal-binding site
498217004374	putative peptidase; Provisional; Region: PRK11649
498217004375	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
498217004376	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
498217004377	Peptidase family M23; Region: Peptidase_M23; pfam01551
498217004378	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
498217004379	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
498217004380	putative acyl-acceptor binding pocket; other site
498217004381	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
498217004382	pyruvate kinase; Provisional; Region: PRK05826
498217004383	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
498217004384	domain interfaces; other site
498217004385	active site
498217004386	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
498217004387	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
498217004388	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
498217004389	putative active site [active]
498217004390	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
498217004391	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
498217004392	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
498217004393	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
498217004394	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
498217004395	putative active site [active]
498217004396	phosphogluconate dehydratase; Validated; Region: PRK09054
498217004397	6-phosphogluconate dehydratase; Region: edd; TIGR01196
498217004398	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
498217004399	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
498217004400	active site
498217004401	intersubunit interface [polypeptide binding]; other site
498217004402	catalytic residue [active]
498217004403	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
498217004404	multidrug efflux system protein MdtI; Provisional; Region: PRK10650
498217004405	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
498217004406	homotrimer interaction site [polypeptide binding]; other site
498217004407	putative active site [active]
498217004408	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
498217004409	DEAD/DEAH box helicase; Region: DEAD; pfam00270
498217004410	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
498217004411	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
498217004412	Glycoprotease family; Region: Peptidase_M22; pfam00814
498217004413	Outer membrane lipoprotein Slp family; Region: Slp; cl01164
498217004414	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
498217004415	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
498217004416	acyl-activating enzyme (AAE) consensus motif; other site
498217004417	putative AMP binding site [chemical binding]; other site
498217004418	putative active site [active]
498217004419	putative CoA binding site [chemical binding]; other site
498217004420	ribonuclease D; Provisional; Region: PRK10829
498217004421	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
498217004422	catalytic site [active]
498217004423	putative active site [active]
498217004424	putative substrate binding site [chemical binding]; other site
498217004425	HRDC domain; Region: HRDC; pfam00570
498217004426	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
498217004427	cell division inhibitor MinD; Provisional; Region: PRK10818
498217004428	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
498217004429	Switch I; other site
498217004430	Switch II; other site
498217004431	septum formation inhibitor; Reviewed; Region: minC; PRK03511
498217004432	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
498217004433	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
498217004434	YcgL domain; Region: YcgL; cl01189
498217004435	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
498217004436	hypothetical protein; Provisional; Region: PRK10691
498217004437	hypothetical protein; Provisional; Region: PRK05170
498217004438	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
498217004439	Ligand Binding Site [chemical binding]; other site
498217004440	disulfide bond formation protein B; Provisional; Region: PRK01749
498217004441	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
498217004442	fatty acid metabolism regulator; Provisional; Region: PRK04984
498217004443	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498217004444	DNA-binding site [nucleotide binding]; DNA binding site
498217004445	FadR C-terminal domain; Region: FadR_C; pfam07840
498217004446	SpoVR family protein; Provisional; Region: PRK11767
498217004447	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
498217004448	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
498217004449	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498217004450	hydroxyglutarate oxidase; Provisional; Region: PRK11728
498217004451	hypothetical protein; Provisional; Region: PRK10174
498217004452	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
498217004453	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
498217004454	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
498217004455	hypothetical protein; Provisional; Region: PRK05325
498217004456	PrkA family serine protein kinase; Provisional; Region: PRK15455
498217004457	AAA ATPase domain; Region: AAA_16; pfam13191
498217004458	Walker A motif; other site
498217004459	ATP binding site [chemical binding]; other site
498217004460	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
498217004461	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
498217004462	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
498217004463	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
498217004464	N-terminal plug; other site
498217004465	ligand-binding site [chemical binding]; other site
498217004466	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
498217004467	active site
498217004468	phosphate binding residues; other site
498217004469	catalytic residues [active]
498217004470	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
498217004471	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
498217004472	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
498217004473	methionine sulfoxide reductase B; Provisional; Region: PRK00222
498217004474	SelR domain; Region: SelR; pfam01641
498217004475	Protein of unknown function (DUF1315); Region: DUF1315; pfam07023
498217004476	Isochorismatase family; Region: Isochorismatase; pfam00857
498217004477	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
498217004478	catalytic triad [active]
498217004479	metal binding site [ion binding]; metal-binding site
498217004480	conserved cis-peptide bond; other site
498217004481	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
498217004482	active site
498217004483	homodimer interface [polypeptide binding]; other site
498217004484	protease 4; Provisional; Region: PRK10949
498217004485	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
498217004486	oligomer interface [polypeptide binding]; other site
498217004487	tandem repeat interface [polypeptide binding]; other site
498217004488	active site residues [active]
498217004489	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
498217004490	tandem repeat interface [polypeptide binding]; other site
498217004491	oligomer interface [polypeptide binding]; other site
498217004492	active site residues [active]
498217004493	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
498217004494	putative FMN binding site [chemical binding]; other site
498217004495	selenophosphate synthetase; Provisional; Region: PRK00943
498217004496	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
498217004497	dimerization interface [polypeptide binding]; other site
498217004498	putative ATP binding site [chemical binding]; other site
498217004499	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
498217004500	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
498217004501	active site residue [active]
498217004502	DNA topoisomerase III; Provisional; Region: PRK07726
498217004503	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
498217004504	active site
498217004505	putative interdomain interaction site [polypeptide binding]; other site
498217004506	putative metal-binding site [ion binding]; other site
498217004507	putative nucleotide binding site [chemical binding]; other site
498217004508	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
498217004509	domain I; other site
498217004510	DNA binding groove [nucleotide binding]
498217004511	phosphate binding site [ion binding]; other site
498217004512	domain II; other site
498217004513	domain III; other site
498217004514	nucleotide binding site [chemical binding]; other site
498217004515	catalytic site [active]
498217004516	domain IV; other site
498217004517	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
498217004518	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
498217004519	active site
498217004520	8-oxo-dGMP binding site [chemical binding]; other site
498217004521	nudix motif; other site
498217004522	metal binding site [ion binding]; metal-binding site
498217004523	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
498217004524	putative catalytic site [active]
498217004525	putative phosphate binding site [ion binding]; other site
498217004526	active site
498217004527	metal binding site A [ion binding]; metal-binding site
498217004528	DNA binding site [nucleotide binding]
498217004529	putative AP binding site [nucleotide binding]; other site
498217004530	putative metal binding site B [ion binding]; other site
498217004531	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
498217004532	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
498217004533	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
498217004534	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
498217004535	putative active site [active]
498217004536	putative substrate binding site [chemical binding]; other site
498217004537	putative cosubstrate binding site; other site
498217004538	catalytic site [active]
498217004539	hypothetical protein; Provisional; Region: PRK01617
498217004540	SEC-C motif; Region: SEC-C; pfam02810
498217004541	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217004542	active site
498217004543	response regulator of RpoS; Provisional; Region: PRK10693
498217004544	phosphorylation site [posttranslational modification]
498217004545	intermolecular recognition site; other site
498217004546	dimerization interface [polypeptide binding]; other site
498217004547	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
498217004548	active site
498217004549	tetramer interface; other site
498217004550	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
498217004551	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
498217004552	thymidine kinase; Provisional; Region: PRK04296
498217004553	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
498217004554	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
498217004555	putative catalytic cysteine [active]
498217004556	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
498217004557	putative active site [active]
498217004558	metal binding site [ion binding]; metal-binding site
498217004559	hypothetical protein; Provisional; Region: PRK11111
498217004560	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
498217004561	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
498217004562	peptide binding site [polypeptide binding]; other site
498217004563	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
498217004564	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217004565	dimer interface [polypeptide binding]; other site
498217004566	conserved gate region; other site
498217004567	putative PBP binding loops; other site
498217004568	ABC-ATPase subunit interface; other site
498217004569	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
498217004570	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
498217004571	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217004572	dimer interface [polypeptide binding]; other site
498217004573	conserved gate region; other site
498217004574	ABC-ATPase subunit interface; other site
498217004575	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
498217004576	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
498217004577	Walker A/P-loop; other site
498217004578	ATP binding site [chemical binding]; other site
498217004579	Q-loop/lid; other site
498217004580	ABC transporter signature motif; other site
498217004581	Walker B; other site
498217004582	D-loop; other site
498217004583	H-loop/switch region; other site
498217004584	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
498217004585	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
498217004586	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
498217004587	Walker A/P-loop; other site
498217004588	ATP binding site [chemical binding]; other site
498217004589	Q-loop/lid; other site
498217004590	ABC transporter signature motif; other site
498217004591	Walker B; other site
498217004592	D-loop; other site
498217004593	H-loop/switch region; other site
498217004594	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
498217004595	dsDNA-mimic protein; Reviewed; Region: PRK05094
498217004596	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
498217004597	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
498217004598	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
498217004599	putative active site [active]
498217004600	catalytic site [active]
498217004601	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
498217004602	putative active site [active]
498217004603	catalytic site [active]
498217004604	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
498217004605	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
498217004606	dimerization interface [polypeptide binding]; other site
498217004607	DPS ferroxidase diiron center [ion binding]; other site
498217004608	ion pore; other site
498217004609	YciI-like protein; Reviewed; Region: PRK11370
498217004610	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
498217004611	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
498217004612	intracellular septation protein A; Reviewed; Region: PRK00259
498217004613	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
498217004614	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
498217004615	Sulfate transporter family; Region: Sulfate_transp; pfam00916
498217004616	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
498217004617	Domain of unknown function (DUF1919); Region: DUF1919; cl01628
498217004618	hypothetical protein; Provisional; Region: PRK02868
498217004619	outer membrane protein W; Provisional; Region: PRK10959
498217004620	BON domain; Region: BON; pfam04972
498217004621	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
498217004622	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
498217004623	substrate binding site [chemical binding]; other site
498217004624	active site
498217004625	catalytic residues [active]
498217004626	heterodimer interface [polypeptide binding]; other site
498217004627	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
498217004628	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
498217004629	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217004630	catalytic residue [active]
498217004631	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
498217004632	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
498217004633	active site
498217004634	ribulose/triose binding site [chemical binding]; other site
498217004635	phosphate binding site [ion binding]; other site
498217004636	substrate (anthranilate) binding pocket [chemical binding]; other site
498217004637	product (indole) binding pocket [chemical binding]; other site
498217004638	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
498217004639	active site
498217004640	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
498217004641	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
498217004642	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
498217004643	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
498217004644	Glutamine amidotransferase class-I; Region: GATase; pfam00117
498217004645	glutamine binding [chemical binding]; other site
498217004646	catalytic triad [active]
498217004647	anthranilate synthase component I; Provisional; Region: PRK13564
498217004648	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
498217004649	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
498217004650	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
498217004651	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
498217004652	active site
498217004653	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
498217004654	hypothetical protein; Provisional; Region: PRK11630
498217004655	Protein of unknown function (DUF2766); Region: DUF2766; pfam10964
498217004656	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217004657	dimer interface [polypeptide binding]; other site
498217004658	conserved gate region; other site
498217004659	putative PBP binding loops; other site
498217004660	ABC-ATPase subunit interface; other site
498217004661	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
498217004662	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498217004663	substrate binding pocket [chemical binding]; other site
498217004664	membrane-bound complex binding site; other site
498217004665	hinge residues; other site
498217004666	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
498217004667	transmembrane helices; other site
498217004668	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
498217004669	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
498217004670	DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440
498217004671	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
498217004672	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
498217004673	RNA binding surface [nucleotide binding]; other site
498217004674	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
498217004675	probable active site [active]
498217004676	cobalamin synthase; Reviewed; Region: cobS; PRK00235
498217004677	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
498217004678	catalytic core [active]
498217004679	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
498217004680	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
498217004681	Walker A motif; other site
498217004682	homodimer interface [polypeptide binding]; other site
498217004683	ATP binding site [chemical binding]; other site
498217004684	hydroxycobalamin binding site [chemical binding]; other site
498217004685	Walker B motif; other site
498217004686	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
498217004687	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
498217004688	NAD(P) binding site [chemical binding]; other site
498217004689	active site
498217004690	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
498217004691	putative inner membrane peptidase; Provisional; Region: PRK11778
498217004692	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
498217004693	tandem repeat interface [polypeptide binding]; other site
498217004694	oligomer interface [polypeptide binding]; other site
498217004695	active site residues [active]
498217004696	hypothetical protein; Provisional; Region: PRK11037
498217004697	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
498217004698	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
498217004699	active site
498217004700	interdomain interaction site; other site
498217004701	putative metal-binding site [ion binding]; other site
498217004702	nucleotide binding site [chemical binding]; other site
498217004703	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
498217004704	domain I; other site
498217004705	DNA binding groove [nucleotide binding]
498217004706	phosphate binding site [ion binding]; other site
498217004707	domain II; other site
498217004708	domain III; other site
498217004709	nucleotide binding site [chemical binding]; other site
498217004710	catalytic site [active]
498217004711	domain IV; other site
498217004712	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
498217004713	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
498217004714	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
498217004715	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
498217004716	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217004717	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
498217004718	substrate binding site [chemical binding]; other site
498217004719	dimerization interface [polypeptide binding]; other site
498217004720	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
498217004721	DNA-binding site [nucleotide binding]; DNA binding site
498217004722	RNA-binding motif; other site
498217004723	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
498217004724	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217004725	S-adenosylmethionine binding site [chemical binding]; other site
498217004726	hypothetical protein; Provisional; Region: PRK02913
498217004727	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
498217004728	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
498217004729	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
498217004730	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
498217004731	active pocket/dimerization site; other site
498217004732	active site
498217004733	phosphorylation site [posttranslational modification]
498217004734	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
498217004735	active site
498217004736	phosphorylation site [posttranslational modification]
498217004737	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
498217004738	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
498217004739	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
498217004740	Transporter associated domain; Region: CorC_HlyC; smart01091
498217004741	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
498217004742	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
498217004743	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
498217004744	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
498217004745	multidrug efflux protein; Reviewed; Region: PRK01766
498217004746	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
498217004747	cation binding site [ion binding]; other site
498217004748	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
498217004749	Lumazine binding domain; Region: Lum_binding; pfam00677
498217004750	Lumazine binding domain; Region: Lum_binding; pfam00677
498217004751	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217004752	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
498217004753	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
498217004754	Bacterial transcriptional regulator; Region: IclR; pfam01614
498217004755	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
498217004756	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
498217004757	inner membrane protein; Provisional; Region: PRK11648
498217004758	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
498217004759	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217004760	motif II; other site
498217004761	YniB-like protein; Region: YniB; pfam14002
498217004762	Phosphotransferase enzyme family; Region: APH; pfam01636
498217004763	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
498217004764	active site
498217004765	ATP binding site [chemical binding]; other site
498217004766	hypothetical protein; Provisional; Region: PRK10593
498217004767	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
498217004768	lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470
498217004769	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
498217004770	N-acetyl-D-glucosamine binding site [chemical binding]; other site
498217004771	catalytic residue [active]
498217004772	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
498217004773	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
498217004774	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217004775	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
498217004776	Walker A/P-loop; other site
498217004777	ATP binding site [chemical binding]; other site
498217004778	Q-loop/lid; other site
498217004779	ABC transporter signature motif; other site
498217004780	Walker B; other site
498217004781	D-loop; other site
498217004782	H-loop/switch region; other site
498217004783	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
498217004784	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217004785	Walker A/P-loop; other site
498217004786	ATP binding site [chemical binding]; other site
498217004787	Q-loop/lid; other site
498217004788	ABC transporter signature motif; other site
498217004789	Walker B; other site
498217004790	D-loop; other site
498217004791	H-loop/switch region; other site
498217004792	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
498217004793	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217004794	putative PBP binding loops; other site
498217004795	ABC-ATPase subunit interface; other site
498217004796	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
498217004797	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217004798	dimer interface [polypeptide binding]; other site
498217004799	conserved gate region; other site
498217004800	putative PBP binding loops; other site
498217004801	ABC-ATPase subunit interface; other site
498217004802	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
498217004803	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
498217004804	Protein of unknown function (DUF805); Region: DUF805; pfam05656
498217004805	penicillin-binding protein 2; Provisional; Region: PRK10795
498217004806	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
498217004807	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
498217004808	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
498217004809	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
498217004810	Ligand Binding Site [chemical binding]; other site
498217004811	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
498217004812	Beta/Gamma crystallin; Region: Crystall; cl02528
498217004813	Uncharacterized conserved protein [Function unknown]; Region: COG1359
498217004814	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
498217004815	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
498217004816	Int/Topo IB signature motif; other site
498217004817	DNA binding site [nucleotide binding]
498217004818	Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003
498217004819	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
498217004820	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
498217004821	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
498217004822	active site
498217004823	DNA binding site [nucleotide binding]
498217004824	Int/Topo IB signature motif; other site
498217004825	Excisionase-like protein; Region: Exc; pfam07825
498217004826	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
498217004827	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
498217004828	MULE transposase domain; Region: MULE; pfam10551
498217004829	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
498217004830	Helix-turn-helix domain; Region: HTH_38; pfam13936
498217004831	Integrase core domain; Region: rve; pfam00665
498217004832	transposase/IS protein; Provisional; Region: PRK09183
498217004833	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217004834	Walker A motif; other site
498217004835	ATP binding site [chemical binding]; other site
498217004836	Walker B motif; other site
498217004837	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
498217004838	ORF6C domain; Region: ORF6C; pfam10552
498217004839	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
498217004840	RecT family; Region: RecT; pfam03837
498217004841	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
498217004842	Protein of unknown function (DUF1761); Region: DUF1761; pfam08570
498217004843	Predicted transcriptional regulator [Transcription]; Region: COG2932
498217004844	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
498217004845	Catalytic site [active]
498217004846	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
498217004847	Helix-turn-helix domain; Region: HTH_36; pfam13730
498217004848	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
498217004849	Protein of unknown function (DUF1364); Region: DUF1364; pfam07102
498217004850	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
498217004851	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
498217004852	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
498217004853	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498217004854	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498217004855	salt bridge; other site
498217004856	non-specific DNA binding site [nucleotide binding]; other site
498217004857	sequence-specific DNA binding site [nucleotide binding]; other site
498217004858	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
498217004859	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
498217004860	Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106
498217004861	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
498217004862	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
498217004863	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
498217004864	AntA/AntB antirepressor; Region: AntA; pfam08346
498217004865	large terminase protein; Provisional; Region: 17; PHA02533
498217004866	Uncharacterized protein conserved in archaea (DUF2114); Region: DUF2114; cl01680
498217004867	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
498217004868	Helix-turn-helix domain; Region: HTH_38; pfam13936
498217004869	Integrase core domain; Region: rve; pfam00665
498217004870	transposase/IS protein; Provisional; Region: PRK09183
498217004871	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217004872	Walker A motif; other site
498217004873	ATP binding site [chemical binding]; other site
498217004874	Walker B motif; other site
498217004875	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498217004876	active site
498217004877	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
498217004878	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
498217004879	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
498217004880	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
498217004881	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
498217004882	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
498217004883	DNA binding residues [nucleotide binding]
498217004884	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
498217004885	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217004886	active site
498217004887	phosphorylation site [posttranslational modification]
498217004888	intermolecular recognition site; other site
498217004889	dimerization interface [polypeptide binding]; other site
498217004890	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
498217004891	dimerization interface [polypeptide binding]; other site
498217004892	DNA binding residues [nucleotide binding]
498217004893	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
498217004894	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217004895	dimer interface [polypeptide binding]; other site
498217004896	phosphorylation site [posttranslational modification]
498217004897	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217004898	ATP binding site [chemical binding]; other site
498217004899	Mg2+ binding site [ion binding]; other site
498217004900	G-X-G motif; other site
498217004901	tetrathionate reductase subunit B; Provisional; Region: PRK14993
498217004902	tetrathionate reductase subunit C; Provisional; Region: PRK14992
498217004903	tetrathionate reductase subunit A; Provisional; Region: PRK14991
498217004904	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
498217004905	molybdopterin cofactor binding site; other site
498217004906	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
498217004907	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
498217004908	putative molybdopterin cofactor binding site; other site
498217004909	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
498217004910	mce related protein; Region: MCE; pfam02470
498217004911	mce related protein; Region: MCE; pfam02470
498217004912	mce related protein; Region: MCE; pfam02470
498217004913	mce related protein; Region: MCE; pfam02470
498217004914	mce related protein; Region: MCE; pfam02470
498217004915	mce related protein; Region: MCE; pfam02470
498217004916	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
498217004917	Paraquat-inducible protein A; Region: PqiA; pfam04403
498217004918	Paraquat-inducible protein A; Region: PqiA; pfam04403
498217004919	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
498217004920	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
498217004921	ProP expression regulator; Provisional; Region: PRK04950
498217004922	ProQ/FINO family; Region: ProQ; pfam04352
498217004923	putative RNA binding sites [nucleotide binding]; other site
498217004924	carboxy-terminal protease; Provisional; Region: PRK11186
498217004925	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
498217004926	protein binding site [polypeptide binding]; other site
498217004927	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
498217004928	Catalytic dyad [active]
498217004929	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
498217004930	alpha-amylase; Reviewed; Region: malS; PRK09505
498217004931	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
498217004932	active site
498217004933	catalytic site [active]
498217004934	heat shock protein HtpX; Provisional; Region: PRK05457
498217004935	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
498217004936	Predicted transcriptional regulator [Transcription]; Region: COG3905
498217004937	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
498217004938	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
498217004939	Glutamate binding site [chemical binding]; other site
498217004940	NAD binding site [chemical binding]; other site
498217004941	catalytic residues [active]
498217004942	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
498217004943	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
498217004944	Na binding site [ion binding]; other site
498217004945	sensor kinase CusS; Provisional; Region: PRK09835
498217004946	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
498217004947	dimerization interface [polypeptide binding]; other site
498217004948	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217004949	dimer interface [polypeptide binding]; other site
498217004950	phosphorylation site [posttranslational modification]
498217004951	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217004952	ATP binding site [chemical binding]; other site
498217004953	Mg2+ binding site [ion binding]; other site
498217004954	G-X-G motif; other site
498217004955	DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836
498217004956	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217004957	active site
498217004958	phosphorylation site [posttranslational modification]
498217004959	intermolecular recognition site; other site
498217004960	dimerization interface [polypeptide binding]; other site
498217004961	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498217004962	DNA binding site [nucleotide binding]
498217004963	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
498217004964	Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
498217004965	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
498217004966	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
498217004967	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
498217004968	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217004969	S-adenosylmethionine binding site [chemical binding]; other site
498217004970	putative transporter; Provisional; Region: PRK11043
498217004971	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217004972	putative substrate translocation pore; other site
498217004973	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
498217004974	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217004975	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
498217004976	dimerization interface [polypeptide binding]; other site
498217004977	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136
498217004978	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217004979	Walker A/P-loop; other site
498217004980	ATP binding site [chemical binding]; other site
498217004981	Q-loop/lid; other site
498217004982	ABC transporter signature motif; other site
498217004983	Walker B; other site
498217004984	D-loop; other site
498217004985	H-loop/switch region; other site
498217004986	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135
498217004987	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
498217004988	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
498217004989	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
498217004990	DNA binding site [nucleotide binding]
498217004991	domain linker motif; other site
498217004992	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
498217004993	dimerization interface [polypeptide binding]; other site
498217004994	ligand binding site [chemical binding]; other site
498217004995	superoxide dismutase; Provisional; Region: PRK10543
498217004996	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
498217004997	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
498217004998	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
498217004999	NlpC/P60 family; Region: NLPC_P60; pfam00877
498217005000	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
498217005001	putative GSH binding site [chemical binding]; other site
498217005002	catalytic residues [active]
498217005003	Predicted permease [General function prediction only]; Region: COG2056
498217005004	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
498217005005	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
498217005006	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
498217005007	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
498217005008	dimer interface [polypeptide binding]; other site
498217005009	catalytic site [active]
498217005010	putative active site [active]
498217005011	putative substrate binding site [chemical binding]; other site
498217005012	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
498217005013	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
498217005014	dimer interface [polypeptide binding]; other site
498217005015	active site
498217005016	metal binding site [ion binding]; metal-binding site
498217005017	glutathione binding site [chemical binding]; other site
498217005018	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
498217005019	MarR family; Region: MarR; pfam01047
498217005020	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
498217005021	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
498217005022	lysozyme inhibitor; Provisional; Region: PRK11372
498217005023	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
498217005024	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
498217005025	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
498217005026	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
498217005027	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
498217005028	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
498217005029	active site
498217005030	HIGH motif; other site
498217005031	dimer interface [polypeptide binding]; other site
498217005032	KMSKS motif; other site
498217005033	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
498217005034	RNA binding surface [nucleotide binding]; other site
498217005035	pyridoxamine kinase; Validated; Region: PRK05756
498217005036	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
498217005037	dimer interface [polypeptide binding]; other site
498217005038	pyridoxal binding site [chemical binding]; other site
498217005039	ATP binding site [chemical binding]; other site
498217005040	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
498217005041	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217005042	putative substrate translocation pore; other site
498217005043	POT family; Region: PTR2; pfam00854
498217005044	endonuclease III; Provisional; Region: PRK10702
498217005045	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
498217005046	minor groove reading motif; other site
498217005047	helix-hairpin-helix signature motif; other site
498217005048	substrate binding pocket [chemical binding]; other site
498217005049	active site
498217005050	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
498217005051	electron transport complex RsxE subunit; Provisional; Region: PRK12405
498217005052	electron transport complex protein RnfG; Validated; Region: PRK01908
498217005053	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
498217005054	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
498217005055	SLBB domain; Region: SLBB; pfam10531
498217005056	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
498217005057	electron transport complex protein RnfB; Provisional; Region: PRK05113
498217005058	Putative Fe-S cluster; Region: FeS; pfam04060
498217005059	4Fe-4S binding domain; Region: Fer4; pfam00037
498217005060	electron transport complex protein RsxA; Provisional; Region: PRK05151
498217005061	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
498217005062	formate--tetrahydrofolate ligase; Provisional; Region: PRK13506
498217005063	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
498217005064	Potassium binding sites [ion binding]; other site
498217005065	Cesium cation binding sites [ion binding]; other site
498217005066	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
498217005067	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
498217005068	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
498217005069	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
498217005070	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
498217005071	active site
498217005072	purine riboside binding site [chemical binding]; other site
498217005073	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
498217005074	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
498217005075	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
498217005076	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
498217005077	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
498217005078	fumarate hydratase; Reviewed; Region: fumC; PRK00485
498217005079	Class II fumarases; Region: Fumarase_classII; cd01362
498217005080	active site
498217005081	tetramer interface [polypeptide binding]; other site
498217005082	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
498217005083	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
498217005084	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217005085	putative substrate translocation pore; other site
498217005086	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
498217005087	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217005088	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
498217005089	dimerization interface [polypeptide binding]; other site
498217005090	substrate binding pocket [chemical binding]; other site
498217005091	MarR family; Region: MarR_2; cl17246
498217005092	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
498217005093	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
498217005094	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
498217005095	AAA domain; Region: AAA_26; pfam13500
498217005096	Haem-binding domain; Region: Haem_bd; pfam14376
498217005097	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
498217005098	CAT RNA binding domain; Region: CAT_RBD; smart01061
498217005099	PRD domain; Region: PRD; pfam00874
498217005100	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
498217005101	active site turn [active]
498217005102	phosphorylation site [posttranslational modification]
498217005103	PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826
498217005104	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
498217005105	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
498217005106	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
498217005107	beta-galactosidase; Region: BGL; TIGR03356
498217005108	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
498217005109	Major Facilitator Superfamily; Region: MFS_1; pfam07690
498217005110	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217005111	putative substrate translocation pore; other site
498217005112	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217005113	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
498217005114	hypothetical protein; Provisional; Region: PRK13659
498217005115	malonic semialdehyde reductase; Provisional; Region: PRK10538
498217005116	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
498217005117	NAD(P) binding site [chemical binding]; other site
498217005118	active site
498217005119	chain length determinant protein WzzB; Provisional; Region: PRK15471
498217005120	Chain length determinant protein; Region: Wzz; pfam02706
498217005121	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
498217005122	dimerization interface [polypeptide binding]; other site
498217005123	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
498217005124	Zn2+ binding site [ion binding]; other site
498217005125	Mg2+ binding site [ion binding]; other site
498217005126	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
498217005127	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
498217005128	Ligand Binding Site [chemical binding]; other site
498217005129	Peptidase family C69; Region: Peptidase_C69; pfam03577
498217005130	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
498217005131	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
498217005132	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
498217005133	dimerization interface [polypeptide binding]; other site
498217005134	putative DNA binding site [nucleotide binding]; other site
498217005135	putative Zn2+ binding site [ion binding]; other site
498217005136	Outer membrane lipoprotein Slp family; Region: Slp; cl01164
498217005137	Cache domain; Region: Cache_1; pfam02743
498217005138	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
498217005139	dimerization interface [polypeptide binding]; other site
498217005140	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
498217005141	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
498217005142	dimer interface [polypeptide binding]; other site
498217005143	putative CheW interface [polypeptide binding]; other site
498217005144	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
498217005145	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
498217005146	hypothetical protein; Provisional; Region: PRK09981
498217005147	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
498217005148	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
498217005149	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
498217005150	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
498217005151	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
498217005152	FAD binding pocket [chemical binding]; other site
498217005153	FAD binding motif [chemical binding]; other site
498217005154	phosphate binding motif [ion binding]; other site
498217005155	beta-alpha-beta structure motif; other site
498217005156	NAD binding pocket [chemical binding]; other site
498217005157	Iron coordination center [ion binding]; other site
498217005158	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
498217005159	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
498217005160	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
498217005161	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
498217005162	ligand binding site [chemical binding]; other site
498217005163	flexible hinge region; other site
498217005164	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
498217005165	putative switch regulator; other site
498217005166	non-specific DNA interactions [nucleotide binding]; other site
498217005167	DNA binding site [nucleotide binding]
498217005168	sequence specific DNA binding site [nucleotide binding]; other site
498217005169	putative cAMP binding site [chemical binding]; other site
498217005170	universal stress protein UspE; Provisional; Region: PRK11175
498217005171	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
498217005172	Ligand Binding Site [chemical binding]; other site
498217005173	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
498217005174	Ligand Binding Site [chemical binding]; other site
498217005175	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
498217005176	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
498217005177	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
498217005178	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
498217005179	ligand binding site [chemical binding]; other site
498217005180	homodimer interface [polypeptide binding]; other site
498217005181	NAD(P) binding site [chemical binding]; other site
498217005182	trimer interface B [polypeptide binding]; other site
498217005183	trimer interface A [polypeptide binding]; other site
498217005184	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
498217005185	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
498217005186	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
498217005187	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
498217005188	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
498217005189	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
498217005190	dihydromonapterin reductase; Provisional; Region: PRK06483
498217005191	NAD(P) binding site [chemical binding]; other site
498217005192	active site
498217005193	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
498217005194	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217005195	active site
498217005196	phosphorylation site [posttranslational modification]
498217005197	intermolecular recognition site; other site
498217005198	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498217005199	DNA binding site [nucleotide binding]
498217005200	sensor protein RstB; Provisional; Region: PRK10604
498217005201	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
498217005202	dimerization interface [polypeptide binding]; other site
498217005203	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217005204	dimer interface [polypeptide binding]; other site
498217005205	phosphorylation site [posttranslational modification]
498217005206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217005207	ATP binding site [chemical binding]; other site
498217005208	Mg2+ binding site [ion binding]; other site
498217005209	G-X-G motif; other site
498217005210	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
498217005211	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
498217005212	active site
498217005213	Zn binding site [ion binding]; other site
498217005214	type III effector phosphothreonine lyase; Provisional; Region: PRK15245
498217005215	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
498217005216	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
498217005217	catalytic core [active]
498217005218	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
498217005219	Protein of unknown function (DUF419); Region: DUF419; pfam04237
498217005220	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
498217005221	Helix-Turn-Helix DNA binding domain of the Cfa transcription regulator; Region: HTH_Cfa; cd04789
498217005222	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
498217005223	DNA binding residues [nucleotide binding]
498217005224	putative dimer interface [polypeptide binding]; other site
498217005225	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217005226	S-adenosylmethionine binding site [chemical binding]; other site
498217005227	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
498217005228	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498217005229	Coenzyme A binding pocket [chemical binding]; other site
498217005230	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498217005231	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498217005232	non-specific DNA binding site [nucleotide binding]; other site
498217005233	salt bridge; other site
498217005234	sequence-specific DNA binding site [nucleotide binding]; other site
498217005235	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
498217005236	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
498217005237	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498217005238	ATP binding site [chemical binding]; other site
498217005239	putative Mg++ binding site [ion binding]; other site
498217005240	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498217005241	nucleotide binding region [chemical binding]; other site
498217005242	ATP-binding site [chemical binding]; other site
498217005243	Helicase associated domain (HA2); Region: HA2; pfam04408
498217005244	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
498217005245	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
498217005246	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784
498217005247	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
498217005248	hypothetical protein; Provisional; Region: PRK10695
498217005249	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
498217005250	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
498217005251	putative ligand binding site [chemical binding]; other site
498217005252	putative NAD binding site [chemical binding]; other site
498217005253	catalytic site [active]
498217005254	Glycogen synthesis protein; Region: GlgS; cl11663
498217005255	META domain; Region: META; cl01245
498217005256	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
498217005257	Domain of unknown function (DUF333); Region: DUF333; pfam03891
498217005258	putative Mg(2+) transport ATPase; Provisional; Region: PRK09977
498217005259	MgtC family; Region: MgtC; pfam02308
498217005260	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
498217005261	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
498217005262	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
498217005263	dimer interface [polypeptide binding]; other site
498217005264	PYR/PP interface [polypeptide binding]; other site
498217005265	TPP binding site [chemical binding]; other site
498217005266	substrate binding site [chemical binding]; other site
498217005267	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
498217005268	Domain of unknown function; Region: EKR; pfam10371
498217005269	4Fe-4S binding domain; Region: Fer4_6; pfam12837
498217005270	4Fe-4S binding domain; Region: Fer4; pfam00037
498217005271	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
498217005272	TPP-binding site [chemical binding]; other site
498217005273	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
498217005274	4Fe-4S binding domain; Region: Fer4; pfam00037
498217005275	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498217005276	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498217005277	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
498217005278	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
498217005279	Ligand Binding Site [chemical binding]; other site
498217005280	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
498217005281	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
498217005282	Cl binding site [ion binding]; other site
498217005283	oligomer interface [polypeptide binding]; other site
498217005284	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
498217005285	CoenzymeA binding site [chemical binding]; other site
498217005286	subunit interaction site [polypeptide binding]; other site
498217005287	PHB binding site; other site
498217005288	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
498217005289	FAD binding domain; Region: FAD_binding_4; pfam01565
498217005290	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
498217005291	putative inner membrane protein; Provisional; Region: PRK10983
498217005292	Domain of unknown function DUF20; Region: UPF0118; pfam01594
498217005293	phosphoenolpyruvate synthase; Validated; Region: PRK06464
498217005294	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
498217005295	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
498217005296	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
498217005297	PEP synthetase regulatory protein; Provisional; Region: PRK05339
498217005298	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
498217005299	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
498217005300	coproporphyrinogen III oxidase; Provisional; Region: PRK09058
498217005301	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
498217005302	FeS/SAM binding site; other site
498217005303	putative heme utilization carrier protein HutX; Region: HutX; TIGR04108
498217005304	NADH(P)-binding; Region: NAD_binding_10; pfam13460
498217005305	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
498217005306	NAD(P) binding site [chemical binding]; other site
498217005307	active site
498217005308	Hemin uptake protein hemP; Region: hemP; pfam10636
498217005309	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
498217005310	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
498217005311	N-terminal plug; other site
498217005312	ligand-binding site [chemical binding]; other site
498217005313	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
498217005314	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
498217005315	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
498217005316	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
498217005317	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
498217005318	putative hemin binding site; other site
498217005319	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
498217005320	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
498217005321	ABC-ATPase subunit  interface; other site
498217005322	dimer interface [polypeptide binding]; other site
498217005323	putative PBP binding regions; other site
498217005324	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
498217005325	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
498217005326	Walker A/P-loop; other site
498217005327	ATP binding site [chemical binding]; other site
498217005328	Q-loop/lid; other site
498217005329	ABC transporter signature motif; other site
498217005330	Walker B; other site
498217005331	D-loop; other site
498217005332	H-loop/switch region; other site
498217005333	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
498217005334	Na binding site [ion binding]; other site
498217005335	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
498217005336	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
498217005337	substrate binding site [chemical binding]; other site
498217005338	ATP binding site [chemical binding]; other site
498217005339	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
498217005340	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
498217005341	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
498217005342	NlpC/P60 family; Region: NLPC_P60; pfam00877
498217005343	vitamin B12-transporter ATPase; Provisional; Region: PRK03695
498217005344	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
498217005345	Walker A/P-loop; other site
498217005346	ATP binding site [chemical binding]; other site
498217005347	Q-loop/lid; other site
498217005348	ABC transporter signature motif; other site
498217005349	Walker B; other site
498217005350	D-loop; other site
498217005351	H-loop/switch region; other site
498217005352	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
498217005353	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
498217005354	ABC-ATPase subunit  interface; other site
498217005355	dimer interface [polypeptide binding]; other site
498217005356	putative PBP binding regions; other site
498217005357	hypothetical protein; Provisional; Region: PRK10708
498217005358	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
498217005359	IHF dimer interface [polypeptide binding]; other site
498217005360	IHF - DNA interface [nucleotide binding]; other site
498217005361	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
498217005362	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
498217005363	putative tRNA-binding site [nucleotide binding]; other site
498217005364	B3/4 domain; Region: B3_4; pfam03483
498217005365	tRNA synthetase B5 domain; Region: B5; smart00874
498217005366	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
498217005367	dimer interface [polypeptide binding]; other site
498217005368	motif 1; other site
498217005369	motif 3; other site
498217005370	motif 2; other site
498217005371	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
498217005372	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
498217005373	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
498217005374	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
498217005375	dimer interface [polypeptide binding]; other site
498217005376	motif 1; other site
498217005377	active site
498217005378	motif 2; other site
498217005379	motif 3; other site
498217005380	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
498217005381	L21 binding site [polypeptide binding]; other site
498217005382	23S rRNA binding site [nucleotide binding]; other site
498217005383	L13 binding site [polypeptide binding]; other site
498217005384	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
498217005385	translation initiation factor IF-3; Region: infC; TIGR00168
498217005386	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
498217005387	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
498217005388	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
498217005389	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
498217005390	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
498217005391	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
498217005392	active site
498217005393	dimer interface [polypeptide binding]; other site
498217005394	motif 1; other site
498217005395	motif 2; other site
498217005396	motif 3; other site
498217005397	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
498217005398	anticodon binding site; other site
498217005399	BCCT family transporter; Region: BCCT; cl00569
498217005400	YobH-like protein; Region: YobH; pfam13996
498217005401	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
498217005402	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
498217005403	dimerization interface [polypeptide binding]; other site
498217005404	DPS ferroxidase diiron center [ion binding]; other site
498217005405	ion pore; other site
498217005406	6-phosphofructokinase 2; Provisional; Region: PRK10294
498217005407	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
498217005408	putative substrate binding site [chemical binding]; other site
498217005409	putative ATP binding site [chemical binding]; other site
498217005410	Protein of unknown function (DUF4060); Region: DUF4060; pfam13269
498217005411	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
498217005412	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
498217005413	trimer interface [polypeptide binding]; other site
498217005414	eyelet of channel; other site
498217005415	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
498217005416	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
498217005417	protease 2; Provisional; Region: PRK10115
498217005418	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
498217005419	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
498217005420	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
498217005421	YebG protein; Region: YebG; pfam07130
498217005422	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
498217005423	DNA-binding site [nucleotide binding]; DNA binding site
498217005424	RNA-binding motif; other site
498217005425	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
498217005426	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
498217005427	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217005428	S-adenosylmethionine binding site [chemical binding]; other site
498217005429	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
498217005430	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
498217005431	ATP-grasp domain; Region: ATP-grasp; pfam02222
498217005432	hypothetical protein; Provisional; Region: PRK05114
498217005433	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
498217005434	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
498217005435	chorismate binding enzyme; Region: Chorismate_bind; cl10555
498217005436	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
498217005437	putative active site [active]
498217005438	putative CoA binding site [chemical binding]; other site
498217005439	nudix motif; other site
498217005440	metal binding site [ion binding]; metal-binding site
498217005441	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
498217005442	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
498217005443	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
498217005444	thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006
498217005445	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
498217005446	4Fe-4S binding domain; Region: Fer4; cl02805
498217005447	thiosulfate reductase PhsA; Provisional; Region: PRK15488
498217005448	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
498217005449	putative [Fe4-S4] binding site [ion binding]; other site
498217005450	putative molybdopterin cofactor binding site [chemical binding]; other site
498217005451	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
498217005452	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
498217005453	putative molybdopterin cofactor binding site; other site
498217005454	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
498217005455	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
498217005456	putative dimer interface [polypeptide binding]; other site
498217005457	active site pocket [active]
498217005458	putative cataytic base [active]
498217005459	cobyric acid synthase; Provisional; Region: PRK00784
498217005460	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
498217005461	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
498217005462	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
498217005463	catalytic triad [active]
498217005464	threonine-phosphate decarboxylase; Provisional; Region: PRK08056
498217005465	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498217005466	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217005467	homodimer interface [polypeptide binding]; other site
498217005468	catalytic residue [active]
498217005469	pyruvate kinase; Provisional; Region: PRK09206
498217005470	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
498217005471	domain interfaces; other site
498217005472	active site
498217005473	murein lipoprotein; Provisional; Region: PRK15396
498217005474	L,D-transpeptidase; Provisional; Region: PRK10190
498217005475	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
498217005476	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
498217005477	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
498217005478	peptide binding site [polypeptide binding]; other site
498217005479	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
498217005480	dimer interface [polypeptide binding]; other site
498217005481	catalytic triad [active]
498217005482	peroxidatic and resolving cysteines [active]
498217005483	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
498217005484	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
498217005485	putative aromatic amino acid binding site; other site
498217005486	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
498217005487	putative active site [active]
498217005488	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217005489	Walker A motif; other site
498217005490	ATP binding site [chemical binding]; other site
498217005491	Walker B motif; other site
498217005492	arginine finger; other site
498217005493	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
498217005494	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
498217005495	active site residue [active]
498217005496	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
498217005497	active site residue [active]
498217005498	hypothetical protein; Provisional; Region: PRK05415
498217005499	Domain of unknown function (DUF697); Region: DUF697; cl12064
498217005500	Predicted ATPase [General function prediction only]; Region: COG3106
498217005501	Phage shock protein PspD (Phageshock_PspD); Region: Phageshock_PspD; cl11512
498217005502	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
498217005503	phage shock protein C; Region: phageshock_pspC; TIGR02978
498217005504	phage shock protein B; Provisional; Region: pspB; PRK09458
498217005505	phage shock protein PspA; Provisional; Region: PRK10698
498217005506	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
498217005507	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217005508	Walker A motif; other site
498217005509	ATP binding site [chemical binding]; other site
498217005510	Walker B motif; other site
498217005511	arginine finger; other site
498217005512	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
498217005513	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
498217005514	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
498217005515	peptide binding site [polypeptide binding]; other site
498217005516	antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110
498217005517	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217005518	dimer interface [polypeptide binding]; other site
498217005519	conserved gate region; other site
498217005520	putative PBP binding loops; other site
498217005521	ABC-ATPase subunit interface; other site
498217005522	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
498217005523	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217005524	dimer interface [polypeptide binding]; other site
498217005525	conserved gate region; other site
498217005526	putative PBP binding loops; other site
498217005527	ABC-ATPase subunit interface; other site
498217005528	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
498217005529	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
498217005530	Walker A/P-loop; other site
498217005531	ATP binding site [chemical binding]; other site
498217005532	Q-loop/lid; other site
498217005533	ABC transporter signature motif; other site
498217005534	Walker B; other site
498217005535	D-loop; other site
498217005536	H-loop/switch region; other site
498217005537	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
498217005538	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
498217005539	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
498217005540	Walker A/P-loop; other site
498217005541	ATP binding site [chemical binding]; other site
498217005542	Q-loop/lid; other site
498217005543	ABC transporter signature motif; other site
498217005544	Walker B; other site
498217005545	D-loop; other site
498217005546	H-loop/switch region; other site
498217005547	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
498217005548	Mechanosensitive ion channel; Region: MS_channel; pfam00924
498217005549	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
498217005550	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
498217005551	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
498217005552	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
498217005553	AMP nucleosidase; Provisional; Region: PRK08292
498217005554	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
498217005555	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
498217005556	exoribonuclease II; Provisional; Region: PRK05054
498217005557	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
498217005558	RNB domain; Region: RNB; pfam00773
498217005559	S1 RNA binding domain; Region: S1; pfam00575
498217005560	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
498217005561	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
498217005562	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
498217005563	metal binding site [ion binding]; metal-binding site
498217005564	dimer interface [polypeptide binding]; other site
498217005565	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
498217005566	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
498217005567	Walker A/P-loop; other site
498217005568	ATP binding site [chemical binding]; other site
498217005569	Q-loop/lid; other site
498217005570	ABC transporter signature motif; other site
498217005571	Walker B; other site
498217005572	D-loop; other site
498217005573	H-loop/switch region; other site
498217005574	TOBE domain; Region: TOBE_2; pfam08402
498217005575	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
498217005576	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217005577	dimer interface [polypeptide binding]; other site
498217005578	conserved gate region; other site
498217005579	putative PBP binding loops; other site
498217005580	ABC-ATPase subunit interface; other site
498217005581	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
498217005582	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217005583	dimer interface [polypeptide binding]; other site
498217005584	conserved gate region; other site
498217005585	putative PBP binding loops; other site
498217005586	ABC-ATPase subunit interface; other site
498217005587	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
498217005588	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
498217005589	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
498217005590	hypothetical protein; Provisional; Region: PRK04940
498217005591	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
498217005592	beta-hexosaminidase; Provisional; Region: PRK05337
498217005593	thiamine kinase; Region: ycfN_thiK; TIGR02721
498217005594	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
498217005595	substrate binding site [chemical binding]; other site
498217005596	Protein of unknown function (DUF3897); Region: DUF3897; pfam13036
498217005597	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
498217005598	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
498217005599	putative dimer interface [polypeptide binding]; other site
498217005600	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
498217005601	nucleotide binding site/active site [active]
498217005602	HIT family signature motif; other site
498217005603	catalytic residue [active]
498217005604	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
498217005605	dimer interface [polypeptide binding]; other site
498217005606	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
498217005607	dimer interface [polypeptide binding]; other site
498217005608	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
498217005609	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
498217005610	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
498217005611	NADP binding site [chemical binding]; other site
498217005612	homodimer interface [polypeptide binding]; other site
498217005613	active site
498217005614	YadA-like C-terminal region; Region: YadA; pfam03895
498217005615	putative outer membrane lipoprotein; Provisional; Region: PRK09967
498217005616	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
498217005617	ligand binding site [chemical binding]; other site
498217005618	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
498217005619	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
498217005620	metal binding site [ion binding]; metal-binding site
498217005621	active site
498217005622	I-site; other site
498217005623	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
498217005624	Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119
498217005625	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
498217005626	Ligand Binding Site [chemical binding]; other site
498217005627	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
498217005628	CHASE domain; Region: CHASE; pfam03924
498217005629	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
498217005630	PAS domain; Region: PAS_9; pfam13426
498217005631	putative active site [active]
498217005632	heme pocket [chemical binding]; other site
498217005633	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
498217005634	PAS domain; Region: PAS_9; pfam13426
498217005635	putative active site [active]
498217005636	heme pocket [chemical binding]; other site
498217005637	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
498217005638	putative active site [active]
498217005639	heme pocket [chemical binding]; other site
498217005640	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217005641	dimer interface [polypeptide binding]; other site
498217005642	phosphorylation site [posttranslational modification]
498217005643	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217005644	ATP binding site [chemical binding]; other site
498217005645	Mg2+ binding site [ion binding]; other site
498217005646	G-X-G motif; other site
498217005647	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
498217005648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217005649	active site
498217005650	phosphorylation site [posttranslational modification]
498217005651	intermolecular recognition site; other site
498217005652	dimerization interface [polypeptide binding]; other site
498217005653	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
498217005654	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217005655	active site
498217005656	phosphorylation site [posttranslational modification]
498217005657	intermolecular recognition site; other site
498217005658	dimerization interface [polypeptide binding]; other site
498217005659	Hpt domain; Region: Hpt; pfam01627
498217005660	putative binding surface; other site
498217005661	active site
498217005662	Response regulator receiver domain; Region: Response_reg; pfam00072
498217005663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217005664	active site
498217005665	phosphorylation site [posttranslational modification]
498217005666	intermolecular recognition site; other site
498217005667	dimerization interface [polypeptide binding]; other site
498217005668	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
498217005669	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
498217005670	metal binding site [ion binding]; metal-binding site
498217005671	active site
498217005672	I-site; other site
498217005673	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217005674	D-galactonate transporter; Region: 2A0114; TIGR00893
498217005675	putative substrate translocation pore; other site
498217005676	Beta/Gamma crystallin; Region: Crystall; cl02528
498217005677	alpha-galactosidase; Provisional; Region: PRK15076
498217005678	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
498217005679	NAD binding site [chemical binding]; other site
498217005680	sugar binding site [chemical binding]; other site
498217005681	divalent metal binding site [ion binding]; other site
498217005682	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
498217005683	dimer interface [polypeptide binding]; other site
498217005684	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
498217005685	Cupin domain; Region: Cupin_2; cl17218
498217005686	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
498217005687	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
498217005688	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
498217005689	binding surface
498217005690	Tetratricopeptide repeat; Region: TPR_16; pfam13432
498217005691	TPR motif; other site
498217005692	Protein of unknown function (DUF560); Region: DUF560; pfam04575
498217005693	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
498217005694	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
498217005695	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
498217005696	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498217005697	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
498217005698	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
498217005699	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
498217005700	putative aldolase; Validated; Region: PRK08130
498217005701	intersubunit interface [polypeptide binding]; other site
498217005702	active site
498217005703	Zn2+ binding site [ion binding]; other site
498217005704	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
498217005705	putative transporter; Provisional; Region: PRK09821
498217005706	GntP family permease; Region: GntP_permease; pfam02447
498217005707	Domain of unknown function (DUF305); Region: DUF305; cl17794
498217005708	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
498217005709	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
498217005710	dimer interface [polypeptide binding]; other site
498217005711	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217005712	catalytic residue [active]
498217005713	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
498217005714	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
498217005715	homodimer interface [polypeptide binding]; other site
498217005716	substrate-cofactor binding pocket; other site
498217005717	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217005718	catalytic residue [active]
498217005719	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
498217005720	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
498217005721	dimer interface [polypeptide binding]; other site
498217005722	PYR/PP interface [polypeptide binding]; other site
498217005723	TPP binding site [chemical binding]; other site
498217005724	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
498217005725	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
498217005726	TPP-binding site [chemical binding]; other site
498217005727	dimer interface [polypeptide binding]; other site
498217005728	OpgC protein; Region: OpgC_C; cl17858
498217005729	Acyltransferase family; Region: Acyl_transf_3; pfam01757
498217005730	Phophatidylserine decarboxylase; Region: PSDC; pfam12588
498217005731	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666
498217005732	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
498217005733	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
498217005734	DXD motif; other site
498217005735	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
498217005736	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
498217005737	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
498217005738	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
498217005739	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
498217005740	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
498217005741	Predicted membrane protein [Function unknown]; Region: COG2246
498217005742	GtrA-like protein; Region: GtrA; pfam04138
498217005743	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
498217005744	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
498217005745	Ligand binding site; other site
498217005746	Putative Catalytic site; other site
498217005747	DXD motif; other site
498217005748	Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264
498217005749	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
498217005750	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
498217005751	Coenzyme A binding pocket [chemical binding]; other site
498217005752	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
498217005753	Bacterial sugar transferase; Region: Bac_transf; pfam02397
498217005754	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
498217005755	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
498217005756	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
498217005757	SLBB domain; Region: SLBB; pfam10531
498217005758	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
498217005759	Chain length determinant protein; Region: Wzz; cl15801
498217005760	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
498217005761	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
498217005762	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
498217005763	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
498217005764	active site
498217005765	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498217005766	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
498217005767	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
498217005768	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
498217005769	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
498217005770	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
498217005771	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
498217005772	trimer interface [polypeptide binding]; other site
498217005773	active site
498217005774	substrate binding site [chemical binding]; other site
498217005775	CoA binding site [chemical binding]; other site
498217005776	Mig-14; Region: Mig-14; pfam07395
498217005777	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
498217005778	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
498217005779	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
498217005780	ABC-ATPase subunit  interface; other site
498217005781	dimer interface [polypeptide binding]; other site
498217005782	putative PBP binding regions; other site
498217005783	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
498217005784	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
498217005785	Walker A/P-loop; other site
498217005786	ATP binding site [chemical binding]; other site
498217005787	Q-loop/lid; other site
498217005788	ABC transporter signature motif; other site
498217005789	Walker B; other site
498217005790	D-loop; other site
498217005791	H-loop/switch region; other site
498217005792	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
498217005793	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
498217005794	IucA / IucC family; Region: IucA_IucC; pfam04183
498217005795	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
498217005796	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
498217005797	IucA / IucC family; Region: IucA_IucC; pfam04183
498217005798	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
498217005799	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
498217005800	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
498217005801	dimer interface [polypeptide binding]; other site
498217005802	active site
498217005803	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
498217005804	catalytic residues [active]
498217005805	substrate binding site [chemical binding]; other site
498217005806	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
498217005807	intersubunit interface [polypeptide binding]; other site
498217005808	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
498217005809	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
498217005810	N-terminal plug; other site
498217005811	ligand-binding site [chemical binding]; other site
498217005812	Domain of unknown function (DUF4041); Region: DUF4041; pfam13250
498217005813	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
498217005814	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
498217005815	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
498217005816	deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269
498217005817	active site
498217005818	catalytic residues [active]
498217005819	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
498217005820	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217005821	putative substrate translocation pore; other site
498217005822	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
498217005823	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
498217005824	substrate binding site [chemical binding]; other site
498217005825	dimer interface [polypeptide binding]; other site
498217005826	ATP binding site [chemical binding]; other site
498217005827	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
498217005828	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
498217005829	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498217005830	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
498217005831	SnoaL-like domain; Region: SnoaL_3; pfam13474
498217005832	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
498217005833	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
498217005834	substrate binding site [chemical binding]; other site
498217005835	PrpF protein; Region: PrpF; pfam04303
498217005836	Propionate catabolism activator; Region: PrpR_N; pfam06506
498217005837	PAS domain; Region: PAS; smart00091
498217005838	PAS domain; Region: PAS_9; pfam13426
498217005839	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217005840	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
498217005841	Walker A motif; other site
498217005842	ATP binding site [chemical binding]; other site
498217005843	Walker B motif; other site
498217005844	arginine finger; other site
498217005845	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
498217005846	TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305
498217005847	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
498217005848	homotrimer interface [polypeptide binding]; other site
498217005849	Walker A motif; other site
498217005850	GTP binding site [chemical binding]; other site
498217005851	Walker B motif; other site
498217005852	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
498217005853	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
498217005854	Walker A/P-loop; other site
498217005855	ATP binding site [chemical binding]; other site
498217005856	Q-loop/lid; other site
498217005857	ABC transporter signature motif; other site
498217005858	Walker B; other site
498217005859	D-loop; other site
498217005860	H-loop/switch region; other site
498217005861	cobyric acid synthase; Provisional; Region: PRK00784
498217005862	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
498217005863	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
498217005864	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
498217005865	catalytic triad [active]
498217005866	cobalt transport protein CbiQ; Provisional; Region: PRK15485
498217005867	cobalt transport protein CbiN; Provisional; Region: PRK02898
498217005868	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
498217005869	cobalt transport protein CbiM; Validated; Region: PRK08319
498217005870	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
498217005871	active site
498217005872	SAM binding site [chemical binding]; other site
498217005873	homodimer interface [polypeptide binding]; other site
498217005874	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
498217005875	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
498217005876	active site
498217005877	C-terminal domain interface [polypeptide binding]; other site
498217005878	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
498217005879	active site
498217005880	N-terminal domain interface [polypeptide binding]; other site
498217005881	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
498217005882	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
498217005883	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
498217005884	active site
498217005885	SAM binding site [chemical binding]; other site
498217005886	homodimer interface [polypeptide binding]; other site
498217005887	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
498217005888	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
498217005889	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
498217005890	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
498217005891	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
498217005892	active site
498217005893	SAM binding site [chemical binding]; other site
498217005894	homodimer interface [polypeptide binding]; other site
498217005895	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
498217005896	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217005897	S-adenosylmethionine binding site [chemical binding]; other site
498217005898	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
498217005899	active site
498217005900	putative homodimer interface [polypeptide binding]; other site
498217005901	SAM binding site [chemical binding]; other site
498217005902	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
498217005903	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
498217005904	Precorrin-8X methylmutase; Region: CbiC; pfam02570
498217005905	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
498217005906	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
498217005907	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
498217005908	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
498217005909	catalytic triad [active]
498217005910	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
498217005911	sensory histidine kinase AtoS; Provisional; Region: PRK11360
498217005912	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
498217005913	putative active site [active]
498217005914	heme pocket [chemical binding]; other site
498217005915	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217005916	dimer interface [polypeptide binding]; other site
498217005917	phosphorylation site [posttranslational modification]
498217005918	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217005919	ATP binding site [chemical binding]; other site
498217005920	Mg2+ binding site [ion binding]; other site
498217005921	G-X-G motif; other site
498217005922	acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361
498217005923	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217005924	active site
498217005925	phosphorylation site [posttranslational modification]
498217005926	intermolecular recognition site; other site
498217005927	dimerization interface [polypeptide binding]; other site
498217005928	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217005929	Walker A motif; other site
498217005930	ATP binding site [chemical binding]; other site
498217005931	Walker B motif; other site
498217005932	arginine finger; other site
498217005933	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
498217005934	acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920
498217005935	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
498217005936	Short chain fatty acid transporter; Region: SCFA_trans; pfam02667
498217005937	putative acyltransferase; Provisional; Region: PRK05790
498217005938	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
498217005939	dimer interface [polypeptide binding]; other site
498217005940	active site
498217005941	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
498217005942	Protein of unknown function (DUF2955); Region: DUF2955; pfam11168
498217005943	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
498217005944	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
498217005945	HlyD family secretion protein; Region: HlyD_3; pfam13437
498217005946	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217005947	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
498217005948	active site
498217005949	motif I; other site
498217005950	motif II; other site
498217005951	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
498217005952	Condensation domain; Region: Condensation; pfam00668
498217005953	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
498217005954	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
498217005955	acyl-activating enzyme (AAE) consensus motif; other site
498217005956	AMP binding site [chemical binding]; other site
498217005957	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
498217005958	Condensation domain; Region: Condensation; pfam00668
498217005959	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
498217005960	Condensation domain; Region: Condensation; pfam00668
498217005961	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
498217005962	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
498217005963	Zn binding site [ion binding]; other site
498217005964	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
498217005965	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
498217005966	Propionate catabolism activator; Region: PrpR_N; pfam06506
498217005967	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
498217005968	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
498217005969	putative active site [active]
498217005970	heme pocket [chemical binding]; other site
498217005971	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217005972	Walker A motif; other site
498217005973	ATP binding site [chemical binding]; other site
498217005974	Walker B motif; other site
498217005975	arginine finger; other site
498217005976	EamA-like transporter family; Region: EamA; pfam00892
498217005977	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
498217005978	metal binding site [ion binding]; metal-binding site
498217005979	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
498217005980	CoA-transferase family III; Region: CoA_transf_3; pfam02515
498217005981	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
498217005982	active site
498217005983	catalytic residues [active]
498217005984	metal binding site [ion binding]; metal-binding site
498217005985	3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism]; Region: LeuC; COG0065
498217005986	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
498217005987	substrate binding site [chemical binding]; other site
498217005988	ligand binding site [chemical binding]; other site
498217005989	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
498217005990	substrate binding site [chemical binding]; other site
498217005991	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
498217005992	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
498217005993	substrate binding site [chemical binding]; other site
498217005994	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
498217005995	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
498217005996	phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832
498217005997	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
498217005998	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
498217005999	active site
498217006000	catalytic site [active]
498217006001	putative DNA binding site [nucleotide binding]; other site
498217006002	GIY-YIG motif/motif A; other site
498217006003	metal binding site [ion binding]; metal-binding site
498217006004	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
498217006005	response regulator; Provisional; Region: PRK09483
498217006006	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217006007	active site
498217006008	phosphorylation site [posttranslational modification]
498217006009	intermolecular recognition site; other site
498217006010	dimerization interface [polypeptide binding]; other site
498217006011	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
498217006012	DNA binding residues [nucleotide binding]
498217006013	dimerization interface [polypeptide binding]; other site
498217006014	hypothetical protein; Provisional; Region: PRK10613
498217006015	GlpM protein; Region: GlpM; cl01212
498217006016	chaperone protein HchA; Provisional; Region: PRK04155
498217006017	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
498217006018	conserved cys residue [active]
498217006019	isocitrate dehydrogenase; Validated; Region: PRK07362
498217006020	isocitrate dehydrogenase; Reviewed; Region: PRK07006
498217006021	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
498217006022	pseudouridine synthase; Region: TIGR00093
498217006023	active site
498217006024	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
498217006025	nudix motif; other site
498217006026	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
498217006027	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
498217006028	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
498217006029	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
498217006030	metal binding site [ion binding]; metal-binding site
498217006031	active site
498217006032	I-site; other site
498217006033	putative lysogenization regulator; Reviewed; Region: PRK00218
498217006034	adenylosuccinate lyase; Provisional; Region: PRK09285
498217006035	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
498217006036	tetramer interface [polypeptide binding]; other site
498217006037	active site
498217006038	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
498217006039	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498217006040	DNA-binding site [nucleotide binding]; DNA binding site
498217006041	UTRA domain; Region: UTRA; pfam07702
498217006042	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
498217006043	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
498217006044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217006045	active site
498217006046	phosphorylation site [posttranslational modification]
498217006047	intermolecular recognition site; other site
498217006048	dimerization interface [polypeptide binding]; other site
498217006049	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498217006050	DNA binding site [nucleotide binding]
498217006051	sensor protein PhoQ; Provisional; Region: PRK10815
498217006052	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
498217006053	HAMP domain; Region: HAMP; pfam00672
498217006054	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217006055	dimer interface [polypeptide binding]; other site
498217006056	phosphorylation site [posttranslational modification]
498217006057	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217006058	ATP binding site [chemical binding]; other site
498217006059	Mg2+ binding site [ion binding]; other site
498217006060	G-X-G motif; other site
498217006061	Uncharacterized conserved protein [Function unknown]; Region: COG2850
498217006062	NAD-dependent deacetylase; Provisional; Region: PRK00481
498217006063	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
498217006064	NAD+ binding site [chemical binding]; other site
498217006065	substrate binding site [chemical binding]; other site
498217006066	Zn binding site [ion binding]; other site
498217006067	fructokinase; Reviewed; Region: PRK09557
498217006068	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
498217006069	nucleotide binding site [chemical binding]; other site
498217006070	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
498217006071	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
498217006072	FtsX-like permease family; Region: FtsX; pfam02687
498217006073	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
498217006074	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
498217006075	Walker A/P-loop; other site
498217006076	ATP binding site [chemical binding]; other site
498217006077	Q-loop/lid; other site
498217006078	ABC transporter signature motif; other site
498217006079	Walker B; other site
498217006080	D-loop; other site
498217006081	H-loop/switch region; other site
498217006082	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
498217006083	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
498217006084	FtsX-like permease family; Region: FtsX; pfam02687
498217006085	transcription-repair coupling factor; Provisional; Region: PRK10689
498217006086	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
498217006087	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498217006088	ATP binding site [chemical binding]; other site
498217006089	putative Mg++ binding site [ion binding]; other site
498217006090	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498217006091	nucleotide binding region [chemical binding]; other site
498217006092	ATP-binding site [chemical binding]; other site
498217006093	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
498217006094	hypothetical protein; Provisional; Region: PRK11280
498217006095	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
498217006096	EamA-like transporter family; Region: EamA; pfam00892
498217006097	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
498217006098	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498217006099	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
498217006100	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
498217006101	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498217006102	DinI-like family; Region: DinI; cl11630
498217006103	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
498217006104	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
498217006105	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
498217006106	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
498217006107	DNA binding residues [nucleotide binding]
498217006108	dimerization interface [polypeptide binding]; other site
498217006109	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
498217006110	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498217006111	DNA-binding site [nucleotide binding]; DNA binding site
498217006112	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498217006113	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217006114	homodimer interface [polypeptide binding]; other site
498217006115	catalytic residue [active]
498217006116	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
498217006117	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
498217006118	lipoprotein; Provisional; Region: PRK10540
498217006119	translation initiation factor Sui1; Validated; Region: PRK06824
498217006120	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
498217006121	putative rRNA binding site [nucleotide binding]; other site
498217006122	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
498217006123	active site
498217006124	dimer interface [polypeptide binding]; other site
498217006125	tetratricopeptide repeat protein; Provisional; Region: PRK11788
498217006126	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
498217006127	TPR motif; other site
498217006128	binding surface
498217006129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
498217006130	binding surface
498217006131	TPR motif; other site
498217006132	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
498217006133	binding surface
498217006134	TPR motif; other site
498217006135	Predicted membrane protein [Function unknown]; Region: COG3771
498217006136	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
498217006137	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
498217006138	active site
498217006139	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
498217006140	dimerization interface [polypeptide binding]; other site
498217006141	active site
498217006142	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
498217006143	Autotransporter beta-domain; Region: Autotransporter; pfam03797
498217006144	Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395
498217006145	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
498217006146	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
498217006147	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
498217006148	active site turn [active]
498217006149	phosphorylation site [posttranslational modification]
498217006150	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
498217006151	active site
498217006152	DNA polymerase III subunit delta'; Validated; Region: PRK07993
498217006153	DNA polymerase III subunit delta'; Validated; Region: PRK08485
498217006154	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
498217006155	thymidylate kinase; Validated; Region: tmk; PRK00698
498217006156	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
498217006157	TMP-binding site; other site
498217006158	ATP-binding site [chemical binding]; other site
498217006159	YceG-like family; Region: YceG; pfam02618
498217006160	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
498217006161	dimerization interface [polypeptide binding]; other site
498217006162	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
498217006163	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
498217006164	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217006165	catalytic residue [active]
498217006166	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
498217006167	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
498217006168	dimer interface [polypeptide binding]; other site
498217006169	active site
498217006170	acyl carrier protein; Provisional; Region: acpP; PRK00982
498217006171	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
498217006172	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
498217006173	NAD(P) binding site [chemical binding]; other site
498217006174	homotetramer interface [polypeptide binding]; other site
498217006175	homodimer interface [polypeptide binding]; other site
498217006176	active site
498217006177	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
498217006178	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
498217006179	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
498217006180	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
498217006181	dimer interface [polypeptide binding]; other site
498217006182	active site
498217006183	CoA binding pocket [chemical binding]; other site
498217006184	putative phosphate acyltransferase; Provisional; Region: PRK05331
498217006185	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
498217006186	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
498217006187	Maf-like protein; Region: Maf; pfam02545
498217006188	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
498217006189	active site
498217006190	dimer interface [polypeptide binding]; other site
498217006191	YadA-like C-terminal region; Region: YadA; pfam03895
498217006192	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
498217006193	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
498217006194	RNA binding surface [nucleotide binding]; other site
498217006195	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
498217006196	active site
498217006197	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
498217006198	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
498217006199	homodimer interface [polypeptide binding]; other site
498217006200	oligonucleotide binding site [chemical binding]; other site
498217006201	Uncharacterized conserved protein [Function unknown]; Region: COG1359
498217006202	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
498217006203	active site
498217006204	substrate binding pocket [chemical binding]; other site
498217006205	dimer interface [polypeptide binding]; other site
498217006206	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
498217006207	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
498217006208	Walker A/P-loop; other site
498217006209	ATP binding site [chemical binding]; other site
498217006210	Q-loop/lid; other site
498217006211	ABC transporter signature motif; other site
498217006212	Walker B; other site
498217006213	D-loop; other site
498217006214	H-loop/switch region; other site
498217006215	TIGR00245 family protein; Region: TIGR00245
498217006216	fumarate hydratase; Provisional; Region: PRK15389
498217006217	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
498217006218	Fumarase C-terminus; Region: Fumerase_C; pfam05683
498217006219	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498217006220	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217006221	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
498217006222	putative dimerization interface [polypeptide binding]; other site
498217006223	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
498217006224	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
498217006225	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
498217006226	NAD(P) binding site [chemical binding]; other site
498217006227	active site
498217006228	acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920
498217006229	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
498217006230	putative acyltransferase; Provisional; Region: PRK05790
498217006231	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
498217006232	dimer interface [polypeptide binding]; other site
498217006233	active site
498217006234	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
498217006235	amphipathic channel; other site
498217006236	Asn-Pro-Ala signature motifs; other site
498217006237	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
498217006238	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
498217006239	Walker A/P-loop; other site
498217006240	ATP binding site [chemical binding]; other site
498217006241	Q-loop/lid; other site
498217006242	ABC transporter signature motif; other site
498217006243	Walker B; other site
498217006244	D-loop; other site
498217006245	H-loop/switch region; other site
498217006246	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
498217006247	flagella biosynthesis protein FliZ; Provisional; Region: PRK11582
498217006248	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
498217006249	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
498217006250	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
498217006251	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
498217006252	DNA binding residues [nucleotide binding]
498217006253	flagellin; Validated; Region: PRK06819
498217006254	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
498217006255	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
498217006256	flagellin; Validated; Region: PRK06819
498217006257	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
498217006258	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
498217006259	flagellar capping protein; Reviewed; Region: fliD; PRK08032
498217006260	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
498217006261	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
498217006262	flagellar protein FliS; Validated; Region: fliS; PRK05685
498217006263	Flagellar protein FliT; Region: FliT; cl05125
498217006264	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
498217006265	DNA-binding site [nucleotide binding]; DNA binding site
498217006266	RNA-binding motif; other site
498217006267	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
498217006268	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
498217006269	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
498217006270	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
498217006271	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
498217006272	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
498217006273	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
498217006274	Uncharacterized conserved protein [Function unknown]; Region: COG3334
498217006275	FliG C-terminal domain; Region: FliG_C; pfam01706
498217006276	flagellar assembly protein H; Validated; Region: fliH; PRK05687
498217006277	Flagellar assembly protein FliH; Region: FliH; pfam02108
498217006278	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960
498217006279	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
498217006280	Walker A motif/ATP binding site; other site
498217006281	Walker B motif; other site
498217006282	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
498217006283	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
498217006284	Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777
498217006285	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
498217006286	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
498217006287	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
498217006288	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
498217006289	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
498217006290	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
498217006291	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
498217006292	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
498217006293	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
498217006294	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
498217006295	Peptidase M15; Region: Peptidase_M15_3; cl01194
498217006296	murein L,D-transpeptidase; Provisional; Region: PRK10594
498217006297	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
498217006298	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
498217006299	cell division protein MukB; Provisional; Region: mukB; PRK04863
498217006300	P-loop containing region of AAA domain; Region: AAA_29; cl17516
498217006301	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
498217006302	condesin subunit E; Provisional; Region: PRK05256
498217006303	condesin subunit F; Provisional; Region: PRK05260
498217006304	Methyltransferase domain; Region: Methyltransf_31; pfam13847
498217006305	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217006306	S-adenosylmethionine binding site [chemical binding]; other site
498217006307	Uncharacterized conserved protein [Function unknown]; Region: COG1434
498217006308	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
498217006309	putative active site [active]
498217006310	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
498217006311	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
498217006312	active site
498217006313	putative substrate binding pocket [chemical binding]; other site
498217006314	xanthine permease; Region: pbuX; TIGR03173
498217006315	hypothetical protein; Provisional; Region: PRK10593
498217006316	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
498217006317	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
498217006318	Ligand binding site; other site
498217006319	oligomer interface; other site
498217006320	Trm112p-like protein; Region: Trm112p; cl01066
498217006321	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
498217006322	DNA-binding site [nucleotide binding]; DNA binding site
498217006323	RNA-binding motif; other site
498217006324	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
498217006325	DNA-binding site [nucleotide binding]; DNA binding site
498217006326	RNA-binding motif; other site
498217006327	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
498217006328	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
498217006329	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
498217006330	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498217006331	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
498217006332	Walker A/P-loop; other site
498217006333	ATP binding site [chemical binding]; other site
498217006334	Q-loop/lid; other site
498217006335	ABC transporter signature motif; other site
498217006336	Walker B; other site
498217006337	D-loop; other site
498217006338	H-loop/switch region; other site
498217006339	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
498217006340	Competence protein; Region: Competence; pfam03772
498217006341	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
498217006342	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
498217006343	IHF dimer interface [polypeptide binding]; other site
498217006344	IHF - DNA interface [nucleotide binding]; other site
498217006345	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
498217006346	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
498217006347	RNA binding site [nucleotide binding]; other site
498217006348	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
498217006349	RNA binding site [nucleotide binding]; other site
498217006350	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
498217006351	RNA binding site [nucleotide binding]; other site
498217006352	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
498217006353	RNA binding site [nucleotide binding]; other site
498217006354	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
498217006355	RNA binding site [nucleotide binding]; other site
498217006356	cytidylate kinase; Provisional; Region: cmk; PRK00023
498217006357	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
498217006358	CMP-binding site; other site
498217006359	The sites determining sugar specificity; other site
498217006360	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
498217006361	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
498217006362	hinge; other site
498217006363	active site
498217006364	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
498217006365	homodimer interface [polypeptide binding]; other site
498217006366	substrate-cofactor binding pocket; other site
498217006367	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217006368	catalytic residue [active]
498217006369	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
498217006370	active site
498217006371	homodimer interface [polypeptide binding]; other site
498217006372	uncharacterized domain; Region: TIGR00702
498217006373	YcaO-like family; Region: YcaO; pfam02624
498217006374	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
498217006375	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
498217006376	Pyruvate formate lyase 1; Region: PFL1; cd01678
498217006377	coenzyme A binding site [chemical binding]; other site
498217006378	active site
498217006379	catalytic residues [active]
498217006380	glycine loop; other site
498217006381	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
498217006382	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
498217006383	FeS/SAM binding site; other site
498217006384	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
498217006385	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498217006386	Protein of unknown function, DUF417; Region: DUF417; cl01162
498217006387	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
498217006388	catalytic residues [active]
498217006389	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
498217006390	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
498217006391	Protein of unknown function (DUF1471); Region: DUF1471; cl11507
498217006392	putative MFS family transporter protein; Provisional; Region: PRK03633
498217006393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217006394	putative substrate translocation pore; other site
498217006395	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
498217006396	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
498217006397	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
498217006398	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
498217006399	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
498217006400	4Fe-4S binding domain; Region: Fer4; cl02805
498217006401	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
498217006402	molybdopterin cofactor binding site; other site
498217006403	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
498217006404	putative molybdopterin cofactor binding site; other site
498217006405	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
498217006406	seryl-tRNA synthetase; Provisional; Region: PRK05431
498217006407	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
498217006408	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
498217006409	dimer interface [polypeptide binding]; other site
498217006410	active site
498217006411	motif 1; other site
498217006412	motif 2; other site
498217006413	motif 3; other site
498217006414	recombination factor protein RarA; Reviewed; Region: PRK13342
498217006415	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217006416	Walker A motif; other site
498217006417	ATP binding site [chemical binding]; other site
498217006418	Walker B motif; other site
498217006419	arginine finger; other site
498217006420	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
498217006421	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
498217006422	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
498217006423	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
498217006424	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
498217006425	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
498217006426	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
498217006427	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
498217006428	putative DNA binding site [nucleotide binding]; other site
498217006429	putative Zn2+ binding site [ion binding]; other site
498217006430	AsnC family; Region: AsnC_trans_reg; pfam01037
498217006431	thioredoxin reductase; Provisional; Region: PRK10262
498217006432	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
498217006433	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498217006434	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
498217006435	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
498217006436	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217006437	Walker A/P-loop; other site
498217006438	ATP binding site [chemical binding]; other site
498217006439	Q-loop/lid; other site
498217006440	ABC transporter signature motif; other site
498217006441	Walker B; other site
498217006442	D-loop; other site
498217006443	H-loop/switch region; other site
498217006444	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
498217006445	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217006446	Walker A/P-loop; other site
498217006447	ATP binding site [chemical binding]; other site
498217006448	Q-loop/lid; other site
498217006449	ABC transporter signature motif; other site
498217006450	Walker B; other site
498217006451	D-loop; other site
498217006452	H-loop/switch region; other site
498217006453	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
498217006454	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
498217006455	rRNA binding site [nucleotide binding]; other site
498217006456	predicted 30S ribosome binding site; other site
498217006457	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
498217006458	Clp amino terminal domain; Region: Clp_N; pfam02861
498217006459	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217006460	Walker A motif; other site
498217006461	ATP binding site [chemical binding]; other site
498217006462	Walker B motif; other site
498217006463	arginine finger; other site
498217006464	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217006465	Walker A motif; other site
498217006466	ATP binding site [chemical binding]; other site
498217006467	Walker B motif; other site
498217006468	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
498217006469	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
498217006470	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
498217006471	DNA-binding site [nucleotide binding]; DNA binding site
498217006472	RNA-binding motif; other site
498217006473	Protein of unknown function (DUF535); Region: DUF535; pfam04393
498217006474	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
498217006475	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
498217006476	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
498217006477	putative active site [active]
498217006478	putative metal-binding site [ion binding]; other site
498217006479	Predicted membrane protein [Function unknown]; Region: COG2431
498217006480	hybrid cluster protein; Provisional; Region: PRK05290
498217006481	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
498217006482	ACS interaction site; other site
498217006483	CODH interaction site; other site
498217006484	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
498217006485	hybrid metal cluster; other site
498217006486	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
498217006487	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
498217006488	FAD binding pocket [chemical binding]; other site
498217006489	FAD binding motif [chemical binding]; other site
498217006490	phosphate binding motif [ion binding]; other site
498217006491	beta-alpha-beta structure motif; other site
498217006492	NAD binding pocket [chemical binding]; other site
498217006493	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
498217006494	catalytic loop [active]
498217006495	iron binding site [ion binding]; other site
498217006496	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
498217006497	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
498217006498	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
498217006499	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
498217006500	PapC N-terminal domain; Region: PapC_N; pfam13954
498217006501	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
498217006502	PapC C-terminal domain; Region: PapC_C; pfam13953
498217006503	Fimbrial protein; Region: Fimbrial; pfam00419
498217006504	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
498217006505	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
498217006506	tetramer interface [polypeptide binding]; other site
498217006507	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217006508	catalytic residue [active]
498217006509	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
498217006510	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
498217006511	putative NAD(P) binding site [chemical binding]; other site
498217006512	putative active site [active]
498217006513	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
498217006514	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
498217006515	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
498217006516	NAD(P) binding site [chemical binding]; other site
498217006517	active site
498217006518	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
498217006519	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
498217006520	amidase catalytic site [active]
498217006521	Zn binding residues [ion binding]; other site
498217006522	substrate binding site [chemical binding]; other site
498217006523	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
498217006524	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
498217006525	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
498217006526	dimerization interface [polypeptide binding]; other site
498217006527	DNA binding residues [nucleotide binding]
498217006528	Fimbrial protein; Region: Fimbrial; cl01416
498217006529	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
498217006530	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
498217006531	fimbrial outer membrane usher protein; Provisional; Region: PRK15217
498217006532	PapC N-terminal domain; Region: PapC_N; pfam13954
498217006533	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
498217006534	PapC C-terminal domain; Region: PapC_C; pfam13953
498217006535	putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216
498217006536	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
498217006537	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217006538	Walker A/P-loop; other site
498217006539	ATP binding site [chemical binding]; other site
498217006540	Q-loop/lid; other site
498217006541	ABC transporter signature motif; other site
498217006542	Walker B; other site
498217006543	D-loop; other site
498217006544	H-loop/switch region; other site
498217006545	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
498217006546	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498217006547	substrate binding pocket [chemical binding]; other site
498217006548	membrane-bound complex binding site; other site
498217006549	hinge residues; other site
498217006550	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
498217006551	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217006552	dimer interface [polypeptide binding]; other site
498217006553	conserved gate region; other site
498217006554	putative PBP binding loops; other site
498217006555	ABC-ATPase subunit interface; other site
498217006556	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217006557	dimer interface [polypeptide binding]; other site
498217006558	conserved gate region; other site
498217006559	putative PBP binding loops; other site
498217006560	ABC-ATPase subunit interface; other site
498217006561	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
498217006562	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498217006563	substrate binding pocket [chemical binding]; other site
498217006564	membrane-bound complex binding site; other site
498217006565	hinge residues; other site
498217006566	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
498217006567	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
498217006568	DNA binding site [nucleotide binding]
498217006569	active site
498217006570	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
498217006571	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
498217006572	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
498217006573	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
498217006574	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
498217006575	dimer interface [polypeptide binding]; other site
498217006576	FMN binding site [chemical binding]; other site
498217006577	NADPH bind site [chemical binding]; other site
498217006578	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
498217006579	GSH binding site [chemical binding]; other site
498217006580	catalytic residues [active]
498217006581	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
498217006582	putative transporter; Provisional; Region: PRK04972
498217006583	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
498217006584	TrkA-C domain; Region: TrkA_C; pfam02080
498217006585	TrkA-C domain; Region: TrkA_C; pfam02080
498217006586	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
498217006587	Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012
498217006588	Fimbrial protein; Region: Fimbrial; pfam00419
498217006589	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
498217006590	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
498217006591	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
498217006592	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
498217006593	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
498217006594	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
498217006595	putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284
498217006596	PapC N-terminal domain; Region: PapC_N; pfam13954
498217006597	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
498217006598	PapC C-terminal domain; Region: PapC_C; pfam13953
498217006599	Fimbrial protein; Region: Fimbrial; cl01416
498217006600	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
498217006601	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
498217006602	active site
498217006603	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
498217006604	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
498217006605	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
498217006606	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498217006607	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
498217006608	serine transporter; Region: stp; TIGR00814
498217006609	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
498217006610	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
498217006611	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
498217006612	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
498217006613	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
498217006614	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
498217006615	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
498217006616	substrate binding site [chemical binding]; other site
498217006617	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
498217006618	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
498217006619	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
498217006620	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
498217006621	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
498217006622	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
498217006623	FeS/SAM binding site; other site
498217006624	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
498217006625	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
498217006626	putative NAD(P) binding site [chemical binding]; other site
498217006627	Peptidase family C69; Region: Peptidase_C69; pfam03577
498217006628	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
498217006629	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
498217006630	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
498217006631	histidinol dehydrogenase; Region: hisD; TIGR00069
498217006632	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
498217006633	NAD binding site [chemical binding]; other site
498217006634	dimerization interface [polypeptide binding]; other site
498217006635	product binding site; other site
498217006636	substrate binding site [chemical binding]; other site
498217006637	zinc binding site [ion binding]; other site
498217006638	catalytic residues [active]
498217006639	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
498217006640	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498217006641	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217006642	homodimer interface [polypeptide binding]; other site
498217006643	catalytic residue [active]
498217006644	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
498217006645	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217006646	active site
498217006647	motif I; other site
498217006648	motif II; other site
498217006649	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
498217006650	putative active site pocket [active]
498217006651	4-fold oligomerization interface [polypeptide binding]; other site
498217006652	metal binding residues [ion binding]; metal-binding site
498217006653	3-fold/trimer interface [polypeptide binding]; other site
498217006654	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
498217006655	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
498217006656	putative active site [active]
498217006657	oxyanion strand; other site
498217006658	catalytic triad [active]
498217006659	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
498217006660	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
498217006661	catalytic residues [active]
498217006662	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
498217006663	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
498217006664	substrate binding site [chemical binding]; other site
498217006665	glutamase interaction surface [polypeptide binding]; other site
498217006666	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
498217006667	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
498217006668	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
498217006669	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
498217006670	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
498217006671	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
498217006672	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
498217006673	molybdopterin cofactor binding site [chemical binding]; other site
498217006674	substrate binding site [chemical binding]; other site
498217006675	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
498217006676	molybdopterin cofactor binding site; other site
498217006677	sugar efflux transporter B; Provisional; Region: PRK15011
498217006678	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217006679	putative substrate translocation pore; other site
498217006680	Flagellin N-methylase; Region: FliB; cl00497
498217006681	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
498217006682	aromatic amino acid transport protein; Region: araaP; TIGR00837
498217006683	elongation factor P; Provisional; Region: PRK04542
498217006684	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
498217006685	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
498217006686	RNA binding site [nucleotide binding]; other site
498217006687	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
498217006688	RNA binding site [nucleotide binding]; other site
498217006689	mannonate dehydratase; Provisional; Region: PRK03906
498217006690	mannonate dehydratase; Region: uxuA; TIGR00695
498217006691	D-mannonate oxidoreductase; Provisional; Region: PRK15037
498217006692	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
498217006693	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
498217006694	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
498217006695	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
498217006696	dimer interface [polypeptide binding]; other site
498217006697	ligand binding site [chemical binding]; other site
498217006698	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
498217006699	dimerization interface [polypeptide binding]; other site
498217006700	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
498217006701	dimer interface [polypeptide binding]; other site
498217006702	putative CheW interface [polypeptide binding]; other site
498217006703	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
498217006704	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
498217006705	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
498217006706	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
498217006707	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498217006708	DNA-binding site [nucleotide binding]; DNA binding site
498217006709	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
498217006710	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
498217006711	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
498217006712	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
498217006713	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
498217006714	NlpC/P60 family; Region: NLPC_P60; pfam00877
498217006715	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
498217006716	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
498217006717	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
498217006718	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
498217006719	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
498217006720	active site
498217006721	P-loop; other site
498217006722	phosphorylation site [posttranslational modification]
498217006723	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
498217006724	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
498217006725	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
498217006726	putative substrate binding site [chemical binding]; other site
498217006727	putative ATP binding site [chemical binding]; other site
498217006728	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
498217006729	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498217006730	active site
498217006731	phosphorylation site [posttranslational modification]
498217006732	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
498217006733	dimerization domain swap beta strand [polypeptide binding]; other site
498217006734	regulatory protein interface [polypeptide binding]; other site
498217006735	active site
498217006736	regulatory phosphorylation site [posttranslational modification]; other site
498217006737	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678
498217006738	nudix motif; other site
498217006739	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
498217006740	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498217006741	substrate binding pocket [chemical binding]; other site
498217006742	membrane-bound complex binding site; other site
498217006743	hinge residues; other site
498217006744	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
498217006745	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217006746	dimer interface [polypeptide binding]; other site
498217006747	conserved gate region; other site
498217006748	putative PBP binding loops; other site
498217006749	ABC-ATPase subunit interface; other site
498217006750	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
498217006751	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
498217006752	Walker A/P-loop; other site
498217006753	ATP binding site [chemical binding]; other site
498217006754	Q-loop/lid; other site
498217006755	ABC transporter signature motif; other site
498217006756	Walker B; other site
498217006757	D-loop; other site
498217006758	H-loop/switch region; other site
498217006759	23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727
498217006760	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
498217006761	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
498217006762	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
498217006763	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
498217006764	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217006765	putative substrate translocation pore; other site
498217006766	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
498217006767	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
498217006768	RNA binding surface [nucleotide binding]; other site
498217006769	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
498217006770	active site
498217006771	uracil binding [chemical binding]; other site
498217006772	probable metal-binding protein; Region: matur_matur; TIGR03853
498217006773	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
498217006774	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498217006775	ATP binding site [chemical binding]; other site
498217006776	putative Mg++ binding site [ion binding]; other site
498217006777	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498217006778	nucleotide binding region [chemical binding]; other site
498217006779	ATP-binding site [chemical binding]; other site
498217006780	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
498217006781	5S rRNA interface [nucleotide binding]; other site
498217006782	CTC domain interface [polypeptide binding]; other site
498217006783	L16 interface [polypeptide binding]; other site
498217006784	nucleoid-associated protein NdpA; Validated; Region: PRK00378
498217006785	Nucleoid-associated protein [General function prediction only]; Region: COG3081
498217006786	hypothetical protein; Provisional; Region: PRK13689
498217006787	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
498217006788	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
498217006789	Sulfatase; Region: Sulfatase; cl17466
498217006790	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
498217006791	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
498217006792	metal binding site [ion binding]; metal-binding site
498217006793	active site
498217006794	I-site; other site
498217006795	enolase; Provisional; Region: eno; PRK00077
498217006796	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
498217006797	dimer interface [polypeptide binding]; other site
498217006798	metal binding site [ion binding]; metal-binding site
498217006799	substrate binding pocket [chemical binding]; other site
498217006800	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
498217006801	Ligand Binding Site [chemical binding]; other site
498217006802	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
498217006803	DHH family; Region: DHH; pfam01368
498217006804	DHHA2 domain; Region: DHHA2; pfam02833
498217006805	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
498217006806	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498217006807	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
498217006808	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
498217006809	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
498217006810	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
498217006811	ATP binding site [chemical binding]; other site
498217006812	Mg++ binding site [ion binding]; other site
498217006813	motif III; other site
498217006814	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498217006815	nucleotide binding region [chemical binding]; other site
498217006816	ATP-binding site [chemical binding]; other site
498217006817	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
498217006818	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498217006819	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
498217006820	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
498217006821	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
498217006822	HlyD family secretion protein; Region: HlyD_3; pfam13437
498217006823	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
498217006824	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
498217006825	Walker A/P-loop; other site
498217006826	ATP binding site [chemical binding]; other site
498217006827	Q-loop/lid; other site
498217006828	ABC transporter signature motif; other site
498217006829	Walker B; other site
498217006830	D-loop; other site
498217006831	H-loop/switch region; other site
498217006832	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
498217006833	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
498217006834	Walker A/P-loop; other site
498217006835	ATP binding site [chemical binding]; other site
498217006836	Q-loop/lid; other site
498217006837	ABC transporter signature motif; other site
498217006838	Walker B; other site
498217006839	D-loop; other site
498217006840	H-loop/switch region; other site
498217006841	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
498217006842	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
498217006843	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
498217006844	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
498217006845	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
498217006846	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217006847	ATP binding site [chemical binding]; other site
498217006848	Mg2+ binding site [ion binding]; other site
498217006849	G-X-G motif; other site
498217006850	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
498217006851	putative binding surface; other site
498217006852	active site
498217006853	transcriptional regulator RcsB; Provisional; Region: PRK10840
498217006854	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217006855	active site
498217006856	phosphorylation site [posttranslational modification]
498217006857	intermolecular recognition site; other site
498217006858	dimerization interface [polypeptide binding]; other site
498217006859	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
498217006860	DNA binding residues [nucleotide binding]
498217006861	dimerization interface [polypeptide binding]; other site
498217006862	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
498217006863	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217006864	dimer interface [polypeptide binding]; other site
498217006865	phosphorylation site [posttranslational modification]
498217006866	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217006867	ATP binding site [chemical binding]; other site
498217006868	Mg2+ binding site [ion binding]; other site
498217006869	G-X-G motif; other site
498217006870	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
498217006871	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217006872	active site
498217006873	phosphorylation site [posttranslational modification]
498217006874	intermolecular recognition site; other site
498217006875	dimerization interface [polypeptide binding]; other site
498217006876	DNA gyrase subunit A; Validated; Region: PRK05560
498217006877	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
498217006878	CAP-like domain; other site
498217006879	active site
498217006880	primary dimer interface [polypeptide binding]; other site
498217006881	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
498217006882	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
498217006883	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
498217006884	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
498217006885	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
498217006886	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
498217006887	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
498217006888	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217006889	S-adenosylmethionine binding site [chemical binding]; other site
498217006890	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
498217006891	ATP cone domain; Region: ATP-cone; pfam03477
498217006892	Class I ribonucleotide reductase; Region: RNR_I; cd01679
498217006893	active site
498217006894	dimer interface [polypeptide binding]; other site
498217006895	catalytic residues [active]
498217006896	effector binding site; other site
498217006897	R2 peptide binding site; other site
498217006898	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
498217006899	dimer interface [polypeptide binding]; other site
498217006900	putative radical transfer pathway; other site
498217006901	diiron center [ion binding]; other site
498217006902	tyrosyl radical; other site
498217006903	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
498217006904	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
498217006905	catalytic loop [active]
498217006906	iron binding site [ion binding]; other site
498217006907	putative oxidoreductase; Provisional; Region: PRK09939
498217006908	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
498217006909	putative molybdopterin cofactor binding site [chemical binding]; other site
498217006910	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
498217006911	putative molybdopterin cofactor binding site; other site
498217006912	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
498217006913	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
498217006914	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
498217006915	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
498217006916	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
498217006917	MoaE homodimer interface [polypeptide binding]; other site
498217006918	MoaD interaction [polypeptide binding]; other site
498217006919	active site residues [active]
498217006920	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
498217006921	MoaE interaction surface [polypeptide binding]; other site
498217006922	MoeB interaction surface [polypeptide binding]; other site
498217006923	thiocarboxylated glycine; other site
498217006924	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
498217006925	trimer interface [polypeptide binding]; other site
498217006926	dimer interface [polypeptide binding]; other site
498217006927	putative active site [active]
498217006928	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
498217006929	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
498217006930	FeS/SAM binding site; other site
498217006931	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
498217006932	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
498217006933	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
498217006934	phosphate binding site [ion binding]; other site
498217006935	putative substrate binding pocket [chemical binding]; other site
498217006936	dimer interface [polypeptide binding]; other site
498217006937	hypothetical protein; Provisional; Region: PRK03673
498217006938	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
498217006939	putative MPT binding site; other site
498217006940	tyrosine transporter TyrP; Provisional; Region: PRK15132
498217006941	aromatic amino acid transport protein; Region: araaP; TIGR00837
498217006942	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
498217006943	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
498217006944	active site
498217006945	HIGH motif; other site
498217006946	dimer interface [polypeptide binding]; other site
498217006947	KMSKS motif; other site
498217006948	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
498217006949	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
498217006950	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
498217006951	acyl-activating enzyme (AAE) consensus motif; other site
498217006952	AMP binding site [chemical binding]; other site
498217006953	active site
498217006954	CoA binding site [chemical binding]; other site
498217006955	O-succinylbenzoate synthase; Provisional; Region: PRK05105
498217006956	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
498217006957	active site
498217006958	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
498217006959	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
498217006960	substrate binding site [chemical binding]; other site
498217006961	oxyanion hole (OAH) forming residues; other site
498217006962	trimer interface [polypeptide binding]; other site
498217006963	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
498217006964	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
498217006965	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
498217006966	dimer interface [polypeptide binding]; other site
498217006967	tetramer interface [polypeptide binding]; other site
498217006968	PYR/PP interface [polypeptide binding]; other site
498217006969	TPP binding site [chemical binding]; other site
498217006970	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
498217006971	TPP-binding site; other site
498217006972	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
498217006973	chorismate binding enzyme; Region: Chorismate_bind; cl10555
498217006974	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
498217006975	Peptidase family C69; Region: Peptidase_C69; pfam03577
498217006976	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
498217006977	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
498217006978	nickel binding site [ion binding]; other site
498217006979	putative substrate-binding site; other site
498217006980	hydrogenase 2 large subunit; Provisional; Region: PRK10467
498217006981	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
498217006982	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
498217006983	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
498217006984	4Fe-4S binding domain; Region: Fer4_6; pfam12837
498217006985	hydrogenase 2 small subunit; Provisional; Region: PRK10468
498217006986	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
498217006987	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822
498217006988	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
498217006989	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
498217006990	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
498217006991	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
498217006992	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
498217006993	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
498217006994	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
498217006995	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
498217006996	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
498217006997	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
498217006998	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
498217006999	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
498217007000	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
498217007001	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
498217007002	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
498217007003	4Fe-4S binding domain; Region: Fer4; pfam00037
498217007004	4Fe-4S binding domain; Region: Fer4; pfam00037
498217007005	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
498217007006	NADH dehydrogenase subunit G; Validated; Region: PRK08166
498217007007	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
498217007008	catalytic loop [active]
498217007009	iron binding site [ion binding]; other site
498217007010	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
498217007011	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
498217007012	[4Fe-4S] binding site [ion binding]; other site
498217007013	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
498217007014	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
498217007015	SLBB domain; Region: SLBB; pfam10531
498217007016	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
498217007017	NADH dehydrogenase subunit E; Validated; Region: PRK07539
498217007018	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
498217007019	putative dimer interface [polypeptide binding]; other site
498217007020	[2Fe-2S] cluster binding site [ion binding]; other site
498217007021	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
498217007022	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
498217007023	NADH dehydrogenase subunit D; Validated; Region: PRK06075
498217007024	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
498217007025	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
498217007026	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
498217007027	putative dimerization interface [polypeptide binding]; other site
498217007028	Uncharacterized conserved protein [Function unknown]; Region: COG0398
498217007029	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
498217007030	Rhodanese Homology Domain; Region: RHOD; smart00450
498217007031	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
498217007032	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
498217007033	active site residue [active]
498217007034	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
498217007035	active site residue [active]
498217007036	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
498217007037	Uncharacterized conserved protein [Function unknown]; Region: COG2128
498217007038	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
498217007039	aminotransferase AlaT; Validated; Region: PRK09265
498217007040	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498217007041	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217007042	homodimer interface [polypeptide binding]; other site
498217007043	catalytic residue [active]
498217007044	5'-nucleotidase; Provisional; Region: PRK03826
498217007045	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
498217007046	TrkA-C domain; Region: TrkA_C; pfam02080
498217007047	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
498217007048	TrkA-C domain; Region: TrkA_C; pfam02080
498217007049	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
498217007050	putative phosphatase; Provisional; Region: PRK11587
498217007051	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217007052	active site
498217007053	motif I; other site
498217007054	motif II; other site
498217007055	hypothetical protein; Validated; Region: PRK05445
498217007056	hypothetical protein; Provisional; Region: PRK01816
498217007057	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
498217007058	propionate/acetate kinase; Provisional; Region: PRK12379
498217007059	phosphate acetyltransferase; Reviewed; Region: PRK05632
498217007060	DRTGG domain; Region: DRTGG; pfam07085
498217007061	phosphate acetyltransferase; Region: pta; TIGR00651
498217007062	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
498217007063	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
498217007064	active site residue [active]
498217007065	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
498217007066	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
498217007067	nudix motif; other site
498217007068	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
498217007069	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
498217007070	active site
498217007071	metal binding site [ion binding]; metal-binding site
498217007072	homotetramer interface [polypeptide binding]; other site
498217007073	glutathione S-transferase; Provisional; Region: PRK15113
498217007074	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
498217007075	C-terminal domain interface [polypeptide binding]; other site
498217007076	GSH binding site (G-site) [chemical binding]; other site
498217007077	dimer interface [polypeptide binding]; other site
498217007078	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
498217007079	N-terminal domain interface [polypeptide binding]; other site
498217007080	putative dimer interface [polypeptide binding]; other site
498217007081	putative substrate binding pocket (H-site) [chemical binding]; other site
498217007082	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
498217007083	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
498217007084	C-terminal domain interface [polypeptide binding]; other site
498217007085	GSH binding site (G-site) [chemical binding]; other site
498217007086	dimer interface [polypeptide binding]; other site
498217007087	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
498217007088	N-terminal domain interface [polypeptide binding]; other site
498217007089	putative dimer interface [polypeptide binding]; other site
498217007090	active site
498217007091	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
498217007092	homooctamer interface [polypeptide binding]; other site
498217007093	active site
498217007094	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
498217007095	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
498217007096	putative NAD(P) binding site [chemical binding]; other site
498217007097	putative active site [active]
498217007098	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
498217007099	classical (c) SDRs; Region: SDR_c; cd05233
498217007100	NAD(P) binding site [chemical binding]; other site
498217007101	active site
498217007102	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
498217007103	Flavoprotein; Region: Flavoprotein; pfam02441
498217007104	amidophosphoribosyltransferase; Provisional; Region: PRK09246
498217007105	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
498217007106	active site
498217007107	tetramer interface [polypeptide binding]; other site
498217007108	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498217007109	active site
498217007110	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
498217007111	colicin V production protein; Provisional; Region: PRK10845
498217007112	cell division protein DedD; Provisional; Region: PRK11633
498217007113	Sporulation related domain; Region: SPOR; pfam05036
498217007114	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
498217007115	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
498217007116	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
498217007117	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
498217007118	hypothetical protein; Provisional; Region: PRK10847
498217007119	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
498217007120	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
498217007121	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
498217007122	dimerization interface 3.5A [polypeptide binding]; other site
498217007123	active site
498217007124	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
498217007125	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
498217007126	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
498217007127	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
498217007128	ligand binding site [chemical binding]; other site
498217007129	NAD binding site [chemical binding]; other site
498217007130	catalytic site [active]
498217007131	homodimer interface [polypeptide binding]; other site
498217007132	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
498217007133	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
498217007134	Methyltransferase domain; Region: Methyltransf_31; pfam13847
498217007135	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217007136	S-adenosylmethionine binding site [chemical binding]; other site
498217007137	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
498217007138	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
498217007139	dimer interface [polypeptide binding]; other site
498217007140	active site
498217007141	Uncharacterized conserved protein [Function unknown]; Region: COG4121
498217007142	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
498217007143	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
498217007144	YfcL protein; Region: YfcL; pfam08891
498217007145	Protein of unknown function, DUF462; Region: DUF462; cl01190
498217007146	hypothetical protein; Provisional; Region: PRK10621
498217007147	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
498217007148	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
498217007149	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
498217007150	NlpC/P60 family; Region: NLPC_P60; cl17555
498217007151	Protein of unknown function (DUF770); Region: DUF770; pfam05591
498217007152	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
498217007153	Protein of unknown function (DUF877); Region: DUF877; pfam05943
498217007154	Protein of unknown function (DUF796); Region: DUF796; pfam05638
498217007155	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
498217007156	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
498217007157	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
498217007158	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
498217007159	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
498217007160	Clp amino terminal domain; Region: Clp_N; pfam02861
498217007161	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217007162	Walker A motif; other site
498217007163	ATP binding site [chemical binding]; other site
498217007164	Walker B motif; other site
498217007165	arginine finger; other site
498217007166	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217007167	ATP binding site [chemical binding]; other site
498217007168	Walker B motif; other site
498217007169	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
498217007170	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
498217007171	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
498217007172	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
498217007173	PAAR motif; Region: PAAR_motif; cl15808
498217007174	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
498217007175	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
498217007176	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
498217007177	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
498217007178	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
498217007179	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
498217007180	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
498217007181	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
498217007182	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
498217007183	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
498217007184	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
498217007185	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
498217007186	Tetramer interface [polypeptide binding]; other site
498217007187	active site
498217007188	FMN-binding site [chemical binding]; other site
498217007189	HemK family putative methylases; Region: hemK_fam; TIGR00536
498217007190	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217007191	S-adenosylmethionine binding site [chemical binding]; other site
498217007192	hypothetical protein; Provisional; Region: PRK04946
498217007193	Smr domain; Region: Smr; pfam01713
498217007194	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
498217007195	catalytic core [active]
498217007196	Protein of unknown function (DUF406); Region: DUF406; pfam04175
498217007197	long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716
498217007198	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
498217007199	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
498217007200	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
498217007201	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
498217007202	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
498217007203	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
498217007204	catalytic residues [active]
498217007205	central insert; other site
498217007206	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
498217007207	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
498217007208	Heme exporter protein D (CcmD); Region: CcmD; cl11475
498217007209	heme exporter protein CcmC; Region: ccmC; TIGR01191
498217007210	heme exporter protein CcmB; Region: ccmB; TIGR01190
498217007211	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
498217007212	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
498217007213	Walker A/P-loop; other site
498217007214	ATP binding site [chemical binding]; other site
498217007215	Q-loop/lid; other site
498217007216	ABC transporter signature motif; other site
498217007217	Walker B; other site
498217007218	D-loop; other site
498217007219	H-loop/switch region; other site
498217007220	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
498217007221	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
498217007222	HlyD family secretion protein; Region: HlyD_3; pfam13437
498217007223	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
498217007224	integrase; Provisional; Region: PRK09692
498217007225	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
498217007226	active site
498217007227	Int/Topo IB signature motif; other site
498217007228	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
498217007229	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
498217007230	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
498217007231	Phage-related protein, tail component [Function unknown]; Region: COG4733
498217007232	Putative phage tail protein; Region: Phage-tail_3; pfam13550
498217007233	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
498217007234	Interdomain contacts; other site
498217007235	Cytokine receptor motif; other site
498217007236	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
498217007237	Interdomain contacts; other site
498217007238	Cytokine receptor motif; other site
498217007239	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
498217007240	Phage-related protein, tail component [Function unknown]; Region: COG4723
498217007241	Phage-related protein [Function unknown]; Region: gp18; COG4672
498217007242	phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541
498217007243	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
498217007244	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
498217007245	Helix-turn-helix domain; Region: HTH_38; pfam13936
498217007246	Integrase core domain; Region: rve; pfam00665
498217007247	transposase/IS protein; Provisional; Region: PRK09183
498217007248	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217007249	Walker A motif; other site
498217007250	ATP binding site [chemical binding]; other site
498217007251	Walker B motif; other site
498217007252	Methyltransferase domain; Region: Methyltransf_25; pfam13649
498217007253	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
498217007254	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
498217007255	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
498217007256	Part of AAA domain; Region: AAA_19; pfam13245
498217007257	AAA domain; Region: AAA_12; pfam13087
498217007258	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
498217007259	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
498217007260	transcriptional regulator protein; Region: phnR; TIGR03337
498217007261	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498217007262	DNA-binding site [nucleotide binding]; DNA binding site
498217007263	UTRA domain; Region: UTRA; cl17743
498217007264	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
498217007265	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217007266	putative substrate translocation pore; other site
498217007267	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
498217007268	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498217007269	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217007270	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
498217007271	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
498217007272	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
498217007273	4Fe-4S binding domain; Region: Fer4; pfam00037
498217007274	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
498217007275	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
498217007276	dimer interface [polypeptide binding]; other site
498217007277	PYR/PP interface [polypeptide binding]; other site
498217007278	TPP binding site [chemical binding]; other site
498217007279	substrate binding site [chemical binding]; other site
498217007280	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
498217007281	Domain of unknown function; Region: EKR; pfam10371
498217007282	4Fe-4S binding domain; Region: Fer4_6; pfam12837
498217007283	4Fe-4S binding domain; Region: Fer4; pfam00037
498217007284	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
498217007285	TPP-binding site [chemical binding]; other site
498217007286	dimer interface [polypeptide binding]; other site
498217007287	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
498217007288	active site residue [active]
498217007289	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
498217007290	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
498217007291	dimerization interface [polypeptide binding]; other site
498217007292	putative DNA binding site [nucleotide binding]; other site
498217007293	putative Zn2+ binding site [ion binding]; other site
498217007294	Transglycosylase SLT domain; Region: SLT_2; pfam13406
498217007295	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
498217007296	N-acetyl-D-glucosamine binding site [chemical binding]; other site
498217007297	catalytic residue [active]
498217007298	carbon starvation protein A; Provisional; Region: PRK15015
498217007299	Carbon starvation protein CstA; Region: CstA; pfam02554
498217007300	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
498217007301	Uncharacterized small protein [Function unknown]; Region: COG2879
498217007302	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
498217007303	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
498217007304	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
498217007305	leucine export protein LeuE; Provisional; Region: PRK10958
498217007306	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
498217007307	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
498217007308	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
498217007309	Serine protease inhibitor ecotin [General function prediction only]; Region: Eco; COG4574
498217007310	secondary substrate binding site; other site
498217007311	primary substrate binding site; other site
498217007312	inhibition loop; other site
498217007313	dimerization interface [polypeptide binding]; other site
498217007314	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
498217007315	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498217007316	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217007317	Walker A/P-loop; other site
498217007318	ATP binding site [chemical binding]; other site
498217007319	ABC transporter signature motif; other site
498217007320	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498217007321	Walker B; other site
498217007322	ABC transporter; Region: ABC_tran_2; pfam12848
498217007323	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498217007324	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
498217007325	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217007326	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
498217007327	dimerization interface [polypeptide binding]; other site
498217007328	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
498217007329	HAMP domain; Region: HAMP; pfam00672
498217007330	dimerization interface [polypeptide binding]; other site
498217007331	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
498217007332	dimer interface [polypeptide binding]; other site
498217007333	putative CheW interface [polypeptide binding]; other site
498217007334	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
498217007335	active site
498217007336	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
498217007337	DJ-1 family protein; Region: not_thiJ; TIGR01383
498217007338	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
498217007339	conserved cys residue [active]
498217007340	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
498217007341	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
498217007342	intersubunit interface [polypeptide binding]; other site
498217007343	active site
498217007344	zinc binding site [ion binding]; other site
498217007345	Na+ binding site [ion binding]; other site
498217007346	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752
498217007347	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
498217007348	Sulfatase; Region: Sulfatase; pfam00884
498217007349	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
498217007350	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
498217007351	FeS/SAM binding site; other site
498217007352	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
498217007353	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
498217007354	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
498217007355	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
498217007356	active site
498217007357	dimer interface [polypeptide binding]; other site
498217007358	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
498217007359	active pocket/dimerization site; other site
498217007360	active site
498217007361	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
498217007362	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
498217007363	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
498217007364	active site
498217007365	phosphorylation site [posttranslational modification]
498217007366	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
498217007367	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
498217007368	dimer interface [polypeptide binding]; other site
498217007369	active site
498217007370	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
498217007371	putative active site [active]
498217007372	tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458
498217007373	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
498217007374	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
498217007375	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498217007376	Protein of unknown function (DUF808); Region: DUF808; pfam05661
498217007377	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
498217007378	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
498217007379	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
498217007380	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
498217007381	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
498217007382	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
498217007383	FMN binding site [chemical binding]; other site
498217007384	active site
498217007385	catalytic residues [active]
498217007386	substrate binding site [chemical binding]; other site
498217007387	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
498217007388	excinuclease ABC subunit B; Provisional; Region: PRK05298
498217007389	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498217007390	ATP binding site [chemical binding]; other site
498217007391	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498217007392	nucleotide binding region [chemical binding]; other site
498217007393	ATP-binding site [chemical binding]; other site
498217007394	Ultra-violet resistance protein B; Region: UvrB; pfam12344
498217007395	UvrB/uvrC motif; Region: UVR; pfam02151
498217007396	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
498217007397	AAA domain; Region: AAA_26; pfam13500
498217007398	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
498217007399	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217007400	S-adenosylmethionine binding site [chemical binding]; other site
498217007401	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
498217007402	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
498217007403	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
498217007404	catalytic residue [active]
498217007405	biotin synthase; Provisional; Region: PRK15108
498217007406	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
498217007407	FeS/SAM binding site; other site
498217007408	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
498217007409	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
498217007410	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
498217007411	inhibitor-cofactor binding pocket; inhibition site
498217007412	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217007413	catalytic residue [active]
498217007414	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
498217007415	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
498217007416	active site
498217007417	motif I; other site
498217007418	motif II; other site
498217007419	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217007420	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
498217007421	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217007422	Walker A/P-loop; other site
498217007423	ATP binding site [chemical binding]; other site
498217007424	Q-loop/lid; other site
498217007425	ABC transporter signature motif; other site
498217007426	Walker B; other site
498217007427	D-loop; other site
498217007428	H-loop/switch region; other site
498217007429	TOBE domain; Region: TOBE; cl01440
498217007430	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
498217007431	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217007432	dimer interface [polypeptide binding]; other site
498217007433	conserved gate region; other site
498217007434	putative PBP binding loops; other site
498217007435	ABC-ATPase subunit interface; other site
498217007436	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
498217007437	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
498217007438	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
498217007439	putative active site [active]
498217007440	Protein of unknown function (DUF2592); Region: DUF2592; pfam10766
498217007441	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
498217007442	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
498217007443	molybdenum-pterin binding domain; Region: Mop; TIGR00638
498217007444	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
498217007445	CAAX protease self-immunity; Region: Abi; pfam02517
498217007446	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
498217007447	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
498217007448	NAD binding site [chemical binding]; other site
498217007449	homodimer interface [polypeptide binding]; other site
498217007450	active site
498217007451	substrate binding site [chemical binding]; other site
498217007452	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
498217007453	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
498217007454	dimer interface [polypeptide binding]; other site
498217007455	active site
498217007456	galactokinase; Provisional; Region: PRK05101
498217007457	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
498217007458	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
498217007459	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
498217007460	active site
498217007461	catalytic residues [active]
498217007462	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
498217007463	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
498217007464	transmembrane helices; other site
498217007465	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
498217007466	catalytic core [active]
498217007467	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
498217007468	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
498217007469	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
498217007470	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
498217007471	Tetratricopeptide repeat; Region: TPR_6; pfam13174
498217007472	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
498217007473	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
498217007474	ligand binding site [chemical binding]; other site
498217007475	translocation protein TolB; Provisional; Region: tolB; PRK03629
498217007476	TolB amino-terminal domain; Region: TolB_N; pfam04052
498217007477	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
498217007478	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
498217007479	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
498217007480	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
498217007481	TolA C-terminal; Region: TolA; pfam06519
498217007482	colicin uptake protein TolR; Provisional; Region: PRK11024
498217007483	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
498217007484	colicin uptake protein TolQ; Provisional; Region: PRK10801
498217007485	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
498217007486	active site
498217007487	hypothetical protein; Provisional; Region: PRK10588
498217007488	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
498217007489	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
498217007490	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
498217007491	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
498217007492	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
498217007493	CoA binding domain; Region: CoA_binding; pfam02629
498217007494	CoA-ligase; Region: Ligase_CoA; pfam00549
498217007495	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
498217007496	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
498217007497	CoA-ligase; Region: Ligase_CoA; pfam00549
498217007498	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
498217007499	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
498217007500	E3 interaction surface; other site
498217007501	lipoyl attachment site [posttranslational modification]; other site
498217007502	e3 binding domain; Region: E3_binding; pfam02817
498217007503	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
498217007504	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
498217007505	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
498217007506	TPP-binding site [chemical binding]; other site
498217007507	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
498217007508	PYR/PP interface [polypeptide binding]; other site
498217007509	dimer interface [polypeptide binding]; other site
498217007510	TPP binding site [chemical binding]; other site
498217007511	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
498217007512	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
498217007513	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
498217007514	L-aspartate oxidase; Provisional; Region: PRK06175
498217007515	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
498217007516	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
498217007517	SdhC subunit interface [polypeptide binding]; other site
498217007518	proximal heme binding site [chemical binding]; other site
498217007519	cardiolipin binding site; other site
498217007520	Iron-sulfur protein interface; other site
498217007521	proximal quinone binding site [chemical binding]; other site
498217007522	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
498217007523	Iron-sulfur protein interface; other site
498217007524	proximal quinone binding site [chemical binding]; other site
498217007525	SdhD (CybS) interface [polypeptide binding]; other site
498217007526	proximal heme binding site [chemical binding]; other site
498217007527	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
498217007528	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
498217007529	dimer interface [polypeptide binding]; other site
498217007530	active site
498217007531	citrylCoA binding site [chemical binding]; other site
498217007532	NADH binding [chemical binding]; other site
498217007533	cationic pore residues; other site
498217007534	oxalacetate/citrate binding site [chemical binding]; other site
498217007535	coenzyme A binding site [chemical binding]; other site
498217007536	catalytic triad [active]
498217007537	endonuclease VIII; Provisional; Region: PRK10445
498217007538	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
498217007539	DNA binding site [nucleotide binding]
498217007540	catalytic residue [active]
498217007541	putative catalytic residues [active]
498217007542	H2TH interface [polypeptide binding]; other site
498217007543	intercalation triad [nucleotide binding]; other site
498217007544	substrate specificity determining residue; other site
498217007545	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
498217007546	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
498217007547	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
498217007548	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
498217007549	hypothetical protein; Provisional; Region: PRK10220
498217007550	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
498217007551	PhnA protein; Region: PhnA; pfam03831
498217007552	Autoinducer binding domain; Region: Autoind_bind; pfam03472
498217007553	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
498217007554	DNA binding residues [nucleotide binding]
498217007555	dimerization interface [polypeptide binding]; other site
498217007556	Autoinducer synthetase; Region: Autoind_synth; pfam00765
498217007557	Uncharacterized conserved protein [Function unknown]; Region: COG0327
498217007558	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
498217007559	cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776
498217007560	DNA photolyase; Region: DNA_photolyase; pfam00875
498217007561	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
498217007562	Protein of unknown function (DUF523); Region: DUF523; pfam04463
498217007563	Uncharacterized conserved protein [Function unknown]; Region: COG3272
498217007564	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
498217007565	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
498217007566	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
498217007567	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
498217007568	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
498217007569	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
498217007570	sensor protein KdpD; Provisional; Region: PRK10490
498217007571	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
498217007572	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
498217007573	Ligand Binding Site [chemical binding]; other site
498217007574	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
498217007575	GAF domain; Region: GAF_3; pfam13492
498217007576	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217007577	dimer interface [polypeptide binding]; other site
498217007578	phosphorylation site [posttranslational modification]
498217007579	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217007580	ATP binding site [chemical binding]; other site
498217007581	Mg2+ binding site [ion binding]; other site
498217007582	G-X-G motif; other site
498217007583	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
498217007584	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217007585	active site
498217007586	phosphorylation site [posttranslational modification]
498217007587	intermolecular recognition site; other site
498217007588	dimerization interface [polypeptide binding]; other site
498217007589	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498217007590	DNA binding site [nucleotide binding]
498217007591	phosphoglucomutase; Validated; Region: PRK07564
498217007592	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
498217007593	active site
498217007594	substrate binding site [chemical binding]; other site
498217007595	metal binding site [ion binding]; metal-binding site
498217007596	replication initiation regulator SeqA; Provisional; Region: PRK11187
498217007597	acyl-CoA esterase; Provisional; Region: PRK10673
498217007598	PGAP1-like protein; Region: PGAP1; pfam07819
498217007599	LexA regulated protein; Provisional; Region: PRK11675
498217007600	flavodoxin FldA; Validated; Region: PRK09267
498217007601	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
498217007602	putative DNA binding helix; other site
498217007603	metal binding site 2 [ion binding]; metal-binding site
498217007604	metal binding site 1 [ion binding]; metal-binding site
498217007605	dimer interface [polypeptide binding]; other site
498217007606	structural Zn2+ binding site [ion binding]; other site
498217007607	Putative carbohydrate binding domain; Region: CHB_HEX; smart01081
498217007608	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525
498217007609	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
498217007610	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569
498217007611	active site
498217007612	C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847
498217007613	YbfN-like lipoprotein; Region: YbfN; pfam13982
498217007614	outer membrane porin, OprD family; Region: OprD; pfam03573
498217007615	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
498217007616	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
498217007617	active site
498217007618	HIGH motif; other site
498217007619	nucleotide binding site [chemical binding]; other site
498217007620	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
498217007621	KMSKS motif; other site
498217007622	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
498217007623	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
498217007624	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
498217007625	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
498217007626	active site turn [active]
498217007627	phosphorylation site [posttranslational modification]
498217007628	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
498217007629	HPr interaction site; other site
498217007630	glycerol kinase (GK) interaction site [polypeptide binding]; other site
498217007631	active site
498217007632	phosphorylation site [posttranslational modification]
498217007633	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
498217007634	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
498217007635	active site
498217007636	trimer interface [polypeptide binding]; other site
498217007637	allosteric site; other site
498217007638	active site lid [active]
498217007639	hexamer (dimer of trimers) interface [polypeptide binding]; other site
498217007640	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
498217007641	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
498217007642	active site
498217007643	dimer interface [polypeptide binding]; other site
498217007644	MarR family; Region: MarR; pfam01047
498217007645	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
498217007646	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
498217007647	nucleotide binding site [chemical binding]; other site
498217007648	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
498217007649	UMP phosphatase; Provisional; Region: PRK10444
498217007650	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217007651	active site
498217007652	motif I; other site
498217007653	motif II; other site
498217007654	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217007655	asparagine synthetase B; Provisional; Region: asnB; PRK09431
498217007656	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
498217007657	active site
498217007658	dimer interface [polypeptide binding]; other site
498217007659	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
498217007660	Ligand Binding Site [chemical binding]; other site
498217007661	Molecular Tunnel; other site
498217007662	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
498217007663	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
498217007664	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
498217007665	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
498217007666	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
498217007667	FeS/SAM binding site; other site
498217007668	TRAM domain; Region: TRAM; pfam01938
498217007669	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
498217007670	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
498217007671	PhoH-like protein; Region: PhoH; pfam02562
498217007672	metal-binding heat shock protein; Provisional; Region: PRK00016
498217007673	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
498217007674	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
498217007675	Transporter associated domain; Region: CorC_HlyC; smart01091
498217007676	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
498217007677	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
498217007678	putative active site [active]
498217007679	catalytic triad [active]
498217007680	putative dimer interface [polypeptide binding]; other site
498217007681	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
498217007682	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498217007683	substrate binding pocket [chemical binding]; other site
498217007684	membrane-bound complex binding site; other site
498217007685	hinge residues; other site
498217007686	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
498217007687	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217007688	dimer interface [polypeptide binding]; other site
498217007689	conserved gate region; other site
498217007690	putative PBP binding loops; other site
498217007691	ABC-ATPase subunit interface; other site
498217007692	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
498217007693	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217007694	dimer interface [polypeptide binding]; other site
498217007695	conserved gate region; other site
498217007696	putative PBP binding loops; other site
498217007697	ABC-ATPase subunit interface; other site
498217007698	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
498217007699	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
498217007700	Walker A/P-loop; other site
498217007701	ATP binding site [chemical binding]; other site
498217007702	Q-loop/lid; other site
498217007703	ABC transporter signature motif; other site
498217007704	Walker B; other site
498217007705	D-loop; other site
498217007706	H-loop/switch region; other site
498217007707	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
498217007708	active site
498217007709	tetramer interface [polypeptide binding]; other site
498217007710	hypothetical protein; Provisional; Region: PRK11032
498217007711	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
498217007712	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
498217007713	HIGH motif; other site
498217007714	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
498217007715	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
498217007716	active site
498217007717	KMSKS motif; other site
498217007718	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
498217007719	tRNA binding surface [nucleotide binding]; other site
498217007720	Lipopolysaccharide-assembly; Region: LptE; cl01125
498217007721	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
498217007722	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
498217007723	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
498217007724	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
498217007725	active site
498217007726	(T/H)XGH motif; other site
498217007727	ribosome-associated protein; Provisional; Region: PRK11538
498217007728	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
498217007729	penicillin-binding protein 2; Provisional; Region: PRK10795
498217007730	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
498217007731	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
498217007732	cell wall shape-determining protein; Provisional; Region: PRK10794
498217007733	rare lipoprotein A; Provisional; Region: PRK10672
498217007734	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
498217007735	Sporulation related domain; Region: SPOR; pfam05036
498217007736	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
498217007737	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
498217007738	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
498217007739	hypothetical protein; Provisional; Region: PRK04998
498217007740	lipoate-protein ligase B; Provisional; Region: PRK14342
498217007741	lipoyl synthase; Provisional; Region: PRK05481
498217007742	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
498217007743	FeS/SAM binding site; other site
498217007744	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
498217007745	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
498217007746	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
498217007747	active site
498217007748	catalytic tetrad [active]
498217007749	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
498217007750	lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470
498217007751	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
498217007752	N-acetyl-D-glucosamine binding site [chemical binding]; other site
498217007753	catalytic residue [active]
498217007754	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
498217007755	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
498217007756	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
498217007757	acyl-activating enzyme (AAE) consensus motif; other site
498217007758	putative AMP binding site [chemical binding]; other site
498217007759	putative active site [active]
498217007760	putative CoA binding site [chemical binding]; other site
498217007761	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
498217007762	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
498217007763	substrate binding site [chemical binding]; other site
498217007764	oxyanion hole (OAH) forming residues; other site
498217007765	trimer interface [polypeptide binding]; other site
498217007766	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
498217007767	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
498217007768	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
498217007769	acyl-activating enzyme (AAE) consensus motif; other site
498217007770	putative AMP binding site [chemical binding]; other site
498217007771	putative active site [active]
498217007772	putative CoA binding site [chemical binding]; other site
498217007773	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
498217007774	CoA-transferase family III; Region: CoA_transf_3; pfam02515
498217007775	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
498217007776	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
498217007777	active site
498217007778	L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356
498217007779	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
498217007780	Ligand binding site [chemical binding]; other site
498217007781	Electron transfer flavoprotein domain; Region: ETF; pfam01012
498217007782	putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363
498217007783	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
498217007784	putative oxidoreductase FixC; Provisional; Region: PRK10157
498217007785	ferredoxin-like protein FixX; Provisional; Region: PRK15449
498217007786	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217007787	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
498217007788	putative substrate translocation pore; other site
498217007789	acetyl esterase; Provisional; Region: PRK10162
498217007790	DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476
498217007791	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
498217007792	Methyltransferase domain; Region: Methyltransf_31; pfam13847
498217007793	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217007794	S-adenosylmethionine binding site [chemical binding]; other site
498217007795	molybdenum transport protein ModD; Provisional; Region: PRK06096
498217007796	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
498217007797	dimerization interface [polypeptide binding]; other site
498217007798	active site
498217007799	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
498217007800	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
498217007801	ParB-like nuclease domain; Region: ParB; smart00470
498217007802	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
498217007803	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
498217007804	Active Sites [active]
498217007805	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
498217007806	potassium uptake protein; Region: kup; TIGR00794
498217007807	K+ potassium transporter; Region: K_trans; pfam02705
498217007808	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
498217007809	homodimer interface [polypeptide binding]; other site
498217007810	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
498217007811	active site pocket [active]
498217007812	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
498217007813	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217007814	ATP binding site [chemical binding]; other site
498217007815	Mg2+ binding site [ion binding]; other site
498217007816	G-X-G motif; other site
498217007817	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
498217007818	anti sigma factor interaction site; other site
498217007819	regulatory phosphorylation site [posttranslational modification]; other site
498217007820	Response regulator receiver domain; Region: Response_reg; pfam00072
498217007821	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217007822	active site
498217007823	phosphorylation site [posttranslational modification]
498217007824	intermolecular recognition site; other site
498217007825	dimerization interface [polypeptide binding]; other site
498217007826	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
498217007827	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
498217007828	potential frameshift: common BLAST hit: gi|238920872|ref|YP_002934387.1| bifunctional glutathionylspermidine synthetase/amidase
498217007829	CHAP domain; Region: CHAP; cl17642
498217007830	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
498217007831	HdeA/HdeB family; Region: HdeA; cl05752
498217007832	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
498217007833	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
498217007834	putative ion selectivity filter; other site
498217007835	putative pore gating glutamate residue; other site
498217007836	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
498217007837	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
498217007838	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
498217007839	homodimer interface [polypeptide binding]; other site
498217007840	NADP binding site [chemical binding]; other site
498217007841	substrate binding site [chemical binding]; other site
498217007842	ribosome-associated protein; Provisional; Region: PRK11507
498217007843	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
498217007844	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
498217007845	active site
498217007846	HIGH motif; other site
498217007847	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
498217007848	KMSKS motif; other site
498217007849	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
498217007850	tRNA binding surface [nucleotide binding]; other site
498217007851	anticodon binding site; other site
498217007852	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
498217007853	substrate binding site [chemical binding]; other site
498217007854	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
498217007855	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
498217007856	metal binding site [ion binding]; metal-binding site
498217007857	active site
498217007858	I-site; other site
498217007859	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
498217007860	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
498217007861	ATP-grasp domain; Region: ATP-grasp; pfam02222
498217007862	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
498217007863	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
498217007864	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
498217007865	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
498217007866	Walker A/P-loop; other site
498217007867	ATP binding site [chemical binding]; other site
498217007868	Q-loop/lid; other site
498217007869	ABC transporter signature motif; other site
498217007870	Walker B; other site
498217007871	D-loop; other site
498217007872	H-loop/switch region; other site
498217007873	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
498217007874	active site
498217007875	catalytic triad [active]
498217007876	oxyanion hole [active]
498217007877	switch loop; other site
498217007878	oxidoreductase; Provisional; Region: PRK08017
498217007879	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
498217007880	NADP binding site [chemical binding]; other site
498217007881	active site
498217007882	steroid binding site; other site
498217007883	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
498217007884	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
498217007885	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
498217007886	hypothetical protein; Provisional; Region: PRK10519
498217007887	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
498217007888	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
498217007889	metal binding site [ion binding]; metal-binding site
498217007890	dimer interface [polypeptide binding]; other site
498217007891	Protein of unknown function (DUF465); Region: DUF465; cl01070
498217007892	enolase; Provisional; Region: eno; PRK00077
498217007893	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
498217007894	dimer interface [polypeptide binding]; other site
498217007895	metal binding site [ion binding]; metal-binding site
498217007896	substrate binding pocket [chemical binding]; other site
498217007897	CTP synthetase; Validated; Region: pyrG; PRK05380
498217007898	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
498217007899	Catalytic site [active]
498217007900	active site
498217007901	UTP binding site [chemical binding]; other site
498217007902	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
498217007903	active site
498217007904	putative oxyanion hole; other site
498217007905	catalytic triad [active]
498217007906	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
498217007907	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
498217007908	homodimer interface [polypeptide binding]; other site
498217007909	metal binding site [ion binding]; metal-binding site
498217007910	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
498217007911	homodimer interface [polypeptide binding]; other site
498217007912	active site
498217007913	putative chemical substrate binding site [chemical binding]; other site
498217007914	metal binding site [ion binding]; metal-binding site
498217007915	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
498217007916	HD domain; Region: HD_4; pfam13328
498217007917	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
498217007918	synthetase active site [active]
498217007919	NTP binding site [chemical binding]; other site
498217007920	metal binding site [ion binding]; metal-binding site
498217007921	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
498217007922	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
498217007923	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
498217007924	TRAM domain; Region: TRAM; pfam01938
498217007925	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217007926	S-adenosylmethionine binding site [chemical binding]; other site
498217007927	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
498217007928	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
498217007929	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
498217007930	dimerization interface [polypeptide binding]; other site
498217007931	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217007932	dimer interface [polypeptide binding]; other site
498217007933	phosphorylation site [posttranslational modification]
498217007934	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217007935	ATP binding site [chemical binding]; other site
498217007936	Mg2+ binding site [ion binding]; other site
498217007937	G-X-G motif; other site
498217007938	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
498217007939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217007940	active site
498217007941	phosphorylation site [posttranslational modification]
498217007942	intermolecular recognition site; other site
498217007943	dimerization interface [polypeptide binding]; other site
498217007944	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
498217007945	putative binding surface; other site
498217007946	active site
498217007947	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
498217007948	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
498217007949	active site
498217007950	hydrophilic channel; other site
498217007951	dimerization interface [polypeptide binding]; other site
498217007952	catalytic residues [active]
498217007953	active site lid [active]
498217007954	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
498217007955	Recombination protein O N terminal; Region: RecO_N; pfam11967
498217007956	Recombination protein O C terminal; Region: RecO_C; pfam02565
498217007957	GTPase Era; Reviewed; Region: era; PRK00089
498217007958	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
498217007959	G1 box; other site
498217007960	GTP/Mg2+ binding site [chemical binding]; other site
498217007961	Switch I region; other site
498217007962	G2 box; other site
498217007963	Switch II region; other site
498217007964	G3 box; other site
498217007965	G4 box; other site
498217007966	G5 box; other site
498217007967	KH domain; Region: KH_2; pfam07650
498217007968	ribonuclease III; Reviewed; Region: rnc; PRK00102
498217007969	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
498217007970	dimerization interface [polypeptide binding]; other site
498217007971	active site
498217007972	metal binding site [ion binding]; metal-binding site
498217007973	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
498217007974	dsRNA binding site [nucleotide binding]; other site
498217007975	signal peptidase I; Provisional; Region: PRK10861
498217007976	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
498217007977	Catalytic site [active]
498217007978	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
498217007979	Catalytic site [active]
498217007980	GTP-binding protein LepA; Provisional; Region: PRK05433
498217007981	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
498217007982	G1 box; other site
498217007983	putative GEF interaction site [polypeptide binding]; other site
498217007984	GTP/Mg2+ binding site [chemical binding]; other site
498217007985	Switch I region; other site
498217007986	G2 box; other site
498217007987	G3 box; other site
498217007988	Switch II region; other site
498217007989	G4 box; other site
498217007990	G5 box; other site
498217007991	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
498217007992	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
498217007993	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
498217007994	SoxR reducing system protein RseC; Provisional; Region: PRK10862
498217007995	anti-sigma E factor; Provisional; Region: rseB; PRK09455
498217007996	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
498217007997	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
498217007998	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
498217007999	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
498217008000	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
498217008001	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
498217008002	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
498217008003	DNA binding residues [nucleotide binding]
498217008004	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
498217008005	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
498217008006	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217008007	S-adenosylmethionine binding site [chemical binding]; other site
498217008008	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
498217008009	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
498217008010	ATP binding site [chemical binding]; other site
498217008011	Mg++ binding site [ion binding]; other site
498217008012	motif III; other site
498217008013	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
498217008014	nucleotide binding region [chemical binding]; other site
498217008015	ATP-binding site [chemical binding]; other site
498217008016	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
498217008017	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
498217008018	ligand binding site [chemical binding]; other site
498217008019	active site
498217008020	UGI interface [polypeptide binding]; other site
498217008021	catalytic site [active]
498217008022	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
498217008023	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
498217008024	dimer interface [polypeptide binding]; other site
498217008025	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
498217008026	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
498217008027	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
498217008028	recombination and repair protein; Provisional; Region: PRK10869
498217008029	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
498217008030	Walker A/P-loop; other site
498217008031	ATP binding site [chemical binding]; other site
498217008032	Q-loop/lid; other site
498217008033	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
498217008034	ABC transporter signature motif; other site
498217008035	Walker B; other site
498217008036	D-loop; other site
498217008037	H-loop/switch region; other site
498217008038	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
498217008039	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
498217008040	hypothetical protein; Validated; Region: PRK01777
498217008041	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
498217008042	putative coenzyme Q binding site [chemical binding]; other site
498217008043	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
498217008044	SmpB-tmRNA interface; other site
498217008045	integrase; Provisional; Region: PRK09692
498217008046	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
498217008047	active site
498217008048	Int/Topo IB signature motif; other site
498217008049	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
498217008050	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
498217008051	Magnesium ion binding site [ion binding]; other site
498217008052	Phage polarity suppression protein (Psu); Region: Psu; pfam07455
498217008053	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
498217008054	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
498217008055	homotrimer interaction site [polypeptide binding]; other site
498217008056	putative active site [active]
498217008057	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
498217008058	AzlC protein; Region: AzlC; pfam03591
498217008059	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
498217008060	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
498217008061	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
498217008062	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
498217008063	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cd00374
498217008064	CAS motifs; other site
498217008065	active site
498217008066	GAF domain; Region: GAF; cl17456
498217008067	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
498217008068	PAS domain; Region: PAS_9; pfam13426
498217008069	putative active site [active]
498217008070	heme pocket [chemical binding]; other site
498217008071	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
498217008072	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
498217008073	metal binding site [ion binding]; metal-binding site
498217008074	active site
498217008075	I-site; other site
498217008076	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
498217008077	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
498217008078	gating phenylalanine in ion channel; other site
498217008079	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
498217008080	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217008081	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
498217008082	putative dimerization interface [polypeptide binding]; other site
498217008083	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
498217008084	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
498217008085	dimerization interface [polypeptide binding]; other site
498217008086	DPS ferroxidase diiron center [ion binding]; other site
498217008087	ion pore; other site
498217008088	Protein of unknown function (DUF1198); Region: DUF1198; pfam06711
498217008089	transcriptional repressor MprA; Provisional; Region: PRK10870
498217008090	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
498217008091	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
498217008092	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
498217008093	HlyD family secretion protein; Region: HlyD_3; pfam13437
498217008094	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
498217008095	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217008096	putative substrate translocation pore; other site
498217008097	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217008098	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
498217008099	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
498217008100	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
498217008101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217008102	ABC-ATPase subunit interface; other site
498217008103	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217008104	ABC-ATPase subunit interface; other site
498217008105	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
498217008106	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217008107	Walker A/P-loop; other site
498217008108	ATP binding site [chemical binding]; other site
498217008109	Q-loop/lid; other site
498217008110	ABC transporter signature motif; other site
498217008111	Walker B; other site
498217008112	D-loop; other site
498217008113	H-loop/switch region; other site
498217008114	serine endoprotease; Provisional; Region: PRK10942
498217008115	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
498217008116	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
498217008117	protein binding site [polypeptide binding]; other site
498217008118	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
498217008119	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
498217008120	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
498217008121	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
498217008122	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
498217008123	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
498217008124	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
498217008125	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
498217008126	cobalamin binding residues [chemical binding]; other site
498217008127	putative BtuC binding residues; other site
498217008128	dimer interface [polypeptide binding]; other site
498217008129	hypothetical protein; Provisional; Region: PRK10578
498217008130	UPF0126 domain; Region: UPF0126; pfam03458
498217008131	UPF0126 domain; Region: UPF0126; pfam03458
498217008132	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
498217008133	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
498217008134	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
498217008135	Cl- selectivity filter; other site
498217008136	Cl- binding residues [ion binding]; other site
498217008137	pore gating glutamate residue; other site
498217008138	dimer interface [polypeptide binding]; other site
498217008139	H+/Cl- coupling transport residue; other site
498217008140	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
498217008141	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
498217008142	inhibitor-cofactor binding pocket; inhibition site
498217008143	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217008144	catalytic residue [active]
498217008145	purine nucleoside phosphorylase; Provisional; Region: PRK08202
498217008146	putative transporter; Provisional; Region: PRK03699
498217008147	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217008148	putative substrate translocation pore; other site
498217008149	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
498217008150	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217008151	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
498217008152	dimerization interface [polypeptide binding]; other site
498217008153	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
498217008154	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
498217008155	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
498217008156	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217008157	putative substrate translocation pore; other site
498217008158	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
498217008159	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
498217008160	GMP synthase; Reviewed; Region: guaA; PRK00074
498217008161	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
498217008162	AMP/PPi binding site [chemical binding]; other site
498217008163	candidate oxyanion hole; other site
498217008164	catalytic triad [active]
498217008165	potential glutamine specificity residues [chemical binding]; other site
498217008166	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
498217008167	ATP Binding subdomain [chemical binding]; other site
498217008168	Ligand Binding sites [chemical binding]; other site
498217008169	Dimerization subdomain; other site
498217008170	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
498217008171	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
498217008172	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
498217008173	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
498217008174	active site
498217008175	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
498217008176	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
498217008177	generic binding surface II; other site
498217008178	generic binding surface I; other site
498217008179	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
498217008180	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
498217008181	TPR motif; other site
498217008182	binding surface
498217008183	Cytochrome C biogenesis protein; Region: CcmH; cl01179
498217008184	heme lyase subunit NrfE; Provisional; Region: PRK10369
498217008185	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
498217008186	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
498217008187	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
498217008188	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
498217008189	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
498217008190	Trm112p-like protein; Region: Trm112p; cl01066
498217008191	Predicted permeases [General function prediction only]; Region: COG0679
498217008192	GTP-binding protein Der; Reviewed; Region: PRK00093
498217008193	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
498217008194	G1 box; other site
498217008195	GTP/Mg2+ binding site [chemical binding]; other site
498217008196	Switch I region; other site
498217008197	G2 box; other site
498217008198	Switch II region; other site
498217008199	G3 box; other site
498217008200	G4 box; other site
498217008201	G5 box; other site
498217008202	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
498217008203	G1 box; other site
498217008204	GTP/Mg2+ binding site [chemical binding]; other site
498217008205	Switch I region; other site
498217008206	G2 box; other site
498217008207	G3 box; other site
498217008208	Switch II region; other site
498217008209	G4 box; other site
498217008210	G5 box; other site
498217008211	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
498217008212	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
498217008213	Trp docking motif [polypeptide binding]; other site
498217008214	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
498217008215	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
498217008216	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
498217008217	dimer interface [polypeptide binding]; other site
498217008218	motif 1; other site
498217008219	active site
498217008220	motif 2; other site
498217008221	motif 3; other site
498217008222	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
498217008223	anticodon binding site; other site
498217008224	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
498217008225	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
498217008226	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
498217008227	cytoskeletal protein RodZ; Provisional; Region: PRK10856
498217008228	Helix-turn-helix domain; Region: HTH_25; pfam13413
498217008229	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
498217008230	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
498217008231	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
498217008232	binding surface
498217008233	TPR motif; other site
498217008234	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
498217008235	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
498217008236	FeS/SAM binding site; other site
498217008237	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
498217008238	active site
498217008239	multimer interface [polypeptide binding]; other site
498217008240	SseB protein; Region: SseB; cl06279
498217008241	aminopeptidase B; Provisional; Region: PRK05015
498217008242	Peptidase; Region: DUF3663; pfam12404
498217008243	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
498217008244	interface (dimer of trimers) [polypeptide binding]; other site
498217008245	Substrate-binding/catalytic site; other site
498217008246	Zn-binding sites [ion binding]; other site
498217008247	Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123
498217008248	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
498217008249	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
498217008250	catalytic loop [active]
498217008251	iron binding site [ion binding]; other site
498217008252	chaperone protein HscA; Provisional; Region: hscA; PRK05183
498217008253	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
498217008254	nucleotide binding site [chemical binding]; other site
498217008255	putative NEF/HSP70 interaction site [polypeptide binding]; other site
498217008256	SBD interface [polypeptide binding]; other site
498217008257	co-chaperone HscB; Provisional; Region: hscB; PRK05014
498217008258	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
498217008259	HSP70 interaction site [polypeptide binding]; other site
498217008260	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
498217008261	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
498217008262	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
498217008263	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
498217008264	trimerization site [polypeptide binding]; other site
498217008265	active site
498217008266	cysteine desulfurase; Provisional; Region: PRK14012
498217008267	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
498217008268	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
498217008269	catalytic residue [active]
498217008270	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
498217008271	Rrf2 family protein; Region: rrf2_super; TIGR00738
498217008272	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
498217008273	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
498217008274	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
498217008275	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
498217008276	active site
498217008277	dimerization interface [polypeptide binding]; other site
498217008278	stationary phase inducible protein CsiE; Provisional; Region: PRK11564
498217008279	PRD domain; Region: PRD; pfam00874
498217008280	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
498217008281	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
498217008282	dimer interface [polypeptide binding]; other site
498217008283	active site
498217008284	glycine-pyridoxal phosphate binding site [chemical binding]; other site
498217008285	folate binding site [chemical binding]; other site
498217008286	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
498217008287	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
498217008288	heme-binding site [chemical binding]; other site
498217008289	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
498217008290	FAD binding pocket [chemical binding]; other site
498217008291	FAD binding motif [chemical binding]; other site
498217008292	phosphate binding motif [ion binding]; other site
498217008293	beta-alpha-beta structure motif; other site
498217008294	NAD binding pocket [chemical binding]; other site
498217008295	Heme binding  pocket [chemical binding]; other site
498217008296	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
498217008297	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
498217008298	active site
498217008299	catalytic site [active]
498217008300	substrate binding site [chemical binding]; other site
498217008301	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
498217008302	RNA/DNA hybrid binding site [nucleotide binding]; other site
498217008303	active site
498217008304	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
498217008305	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
498217008306	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
498217008307	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
498217008308	N-acetyl-D-glucosamine binding site [chemical binding]; other site
498217008309	catalytic residue [active]
498217008310	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
498217008311	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
498217008312	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
498217008313	hypothetical protein; Provisional; Region: PRK05421
498217008314	putative catalytic site [active]
498217008315	putative metal binding site [ion binding]; other site
498217008316	putative phosphate binding site [ion binding]; other site
498217008317	putative catalytic site [active]
498217008318	putative phosphate binding site [ion binding]; other site
498217008319	putative metal binding site [ion binding]; other site
498217008320	protein disaggregation chaperone; Provisional; Region: PRK10865
498217008321	Clp amino terminal domain; Region: Clp_N; pfam02861
498217008322	Clp amino terminal domain; Region: Clp_N; pfam02861
498217008323	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217008324	Walker A motif; other site
498217008325	ATP binding site [chemical binding]; other site
498217008326	Walker B motif; other site
498217008327	arginine finger; other site
498217008328	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217008329	Walker A motif; other site
498217008330	ATP binding site [chemical binding]; other site
498217008331	Walker B motif; other site
498217008332	arginine finger; other site
498217008333	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
498217008334	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
498217008335	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
498217008336	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
498217008337	active site
498217008338	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
498217008339	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
498217008340	30S subunit binding site; other site
498217008341	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
498217008342	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
498217008343	Prephenate dehydratase; Region: PDT; pfam00800
498217008344	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
498217008345	putative L-Phe binding site [chemical binding]; other site
498217008346	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
498217008347	Chorismate mutase type II; Region: CM_2; cl00693
498217008348	prephenate dehydrogenase; Validated; Region: PRK08507
498217008349	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
498217008350	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
498217008351	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
498217008352	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217008353	active site
498217008354	phosphorylation site [posttranslational modification]
498217008355	intermolecular recognition site; other site
498217008356	dimerization interface [polypeptide binding]; other site
498217008357	LytTr DNA-binding domain; Region: LytTR; pfam04397
498217008358	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
498217008359	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
498217008360	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
498217008361	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
498217008362	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
498217008363	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
498217008364	Protein of unknown function, DUF481; Region: DUF481; cl01213
498217008365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217008366	S-adenosylmethionine binding site [chemical binding]; other site
498217008367	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
498217008368	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
498217008369	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
498217008370	RimM N-terminal domain; Region: RimM; pfam01782
498217008371	PRC-barrel domain; Region: PRC; pfam05239
498217008372	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
498217008373	signal recognition particle protein; Provisional; Region: PRK10867
498217008374	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
498217008375	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
498217008376	P loop; other site
498217008377	GTP binding site [chemical binding]; other site
498217008378	Signal peptide binding domain; Region: SRP_SPB; pfam02978
498217008379	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
498217008380	Domain of unknown function DUF21; Region: DUF21; pfam01595
498217008381	hypothetical protein; Provisional; Region: PRK11573
498217008382	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
498217008383	Transporter associated domain; Region: CorC_HlyC; smart01091
498217008384	S-ribosylhomocysteinase; Provisional; Region: PRK02260
498217008385	glutamate--cysteine ligase; Provisional; Region: PRK02107
498217008386	Predicted membrane protein [Function unknown]; Region: COG1238
498217008387	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
498217008388	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217008389	motif II; other site
498217008390	carbon storage regulator; Provisional; Region: PRK01712
498217008391	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
498217008392	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
498217008393	motif 1; other site
498217008394	active site
498217008395	motif 2; other site
498217008396	motif 3; other site
498217008397	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
498217008398	DHHA1 domain; Region: DHHA1; pfam02272
498217008399	recombination regulator RecX; Reviewed; Region: recX; PRK00117
498217008400	recombinase A; Provisional; Region: recA; PRK09354
498217008401	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
498217008402	hexamer interface [polypeptide binding]; other site
498217008403	Walker A motif; other site
498217008404	ATP binding site [chemical binding]; other site
498217008405	Walker B motif; other site
498217008406	Competence-damaged protein; Region: CinA; cl00666
498217008407	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
498217008408	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
498217008409	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
498217008410	Autotransporter beta-domain; Region: Autotransporter; smart00869
498217008411	MarC family integral membrane protein; Region: MarC; cl00919
498217008412	amino acid transporter; Region: 2A0306; TIGR00909
498217008413	glutaminase; Reviewed; Region: PRK12356
498217008414	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
498217008415	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
498217008416	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
498217008417	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217008418	catalytic residue [active]
498217008419	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
498217008420	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
498217008421	dimer interface [polypeptide binding]; other site
498217008422	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
498217008423	putative CheW interface [polypeptide binding]; other site
498217008424	acid-resistance protein; Provisional; Region: hdeB; PRK11566
498217008425	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
498217008426	DNA binding residues [nucleotide binding]
498217008427	dimerization interface [polypeptide binding]; other site
498217008428	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
498217008429	MutS domain I; Region: MutS_I; pfam01624
498217008430	MutS domain II; Region: MutS_II; pfam05188
498217008431	MutS domain III; Region: MutS_III; pfam05192
498217008432	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
498217008433	Walker A/P-loop; other site
498217008434	ATP binding site [chemical binding]; other site
498217008435	Q-loop/lid; other site
498217008436	ABC transporter signature motif; other site
498217008437	Walker B; other site
498217008438	D-loop; other site
498217008439	H-loop/switch region; other site
498217008440	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
498217008441	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
498217008442	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
498217008443	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
498217008444	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
498217008445	DNA binding residues [nucleotide binding]
498217008446	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
498217008447	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
498217008448	Peptidase family M23; Region: Peptidase_M23; pfam01551
498217008449	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
498217008450	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217008451	S-adenosylmethionine binding site [chemical binding]; other site
498217008452	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
498217008453	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
498217008454	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
498217008455	Permutation of conserved domain; other site
498217008456	active site
498217008457	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
498217008458	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
498217008459	homotrimer interaction site [polypeptide binding]; other site
498217008460	zinc binding site [ion binding]; other site
498217008461	CDP-binding sites; other site
498217008462	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
498217008463	substrate binding site; other site
498217008464	dimer interface; other site
498217008465	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
498217008466	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
498217008467	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
498217008468	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
498217008469	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
498217008470	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
498217008471	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
498217008472	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
498217008473	putative active site [active]
498217008474	Ap4A binding site [chemical binding]; other site
498217008475	nudix motif; other site
498217008476	putative metal binding site [ion binding]; other site
498217008477	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
498217008478	putative DNA-binding cleft [nucleotide binding]; other site
498217008479	putative DNA clevage site; other site
498217008480	molecular lever; other site
498217008481	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
498217008482	alkaline phosphatase; Provisional; Region: PRK10518
498217008483	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
498217008484	dimer interface [polypeptide binding]; other site
498217008485	active site
498217008486	lysophospholipid transporter LplT; Provisional; Region: PRK11195
498217008487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217008488	putative substrate translocation pore; other site
498217008489	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
498217008490	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
498217008491	putative acyl-acceptor binding pocket; other site
498217008492	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
498217008493	acyl-activating enzyme (AAE) consensus motif; other site
498217008494	putative AMP binding site [chemical binding]; other site
498217008495	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
498217008496	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
498217008497	DNA binding site [nucleotide binding]
498217008498	domain linker motif; other site
498217008499	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
498217008500	dimerization interface (closed form) [polypeptide binding]; other site
498217008501	ligand binding site [chemical binding]; other site
498217008502	Transcriptional regulators [Transcription]; Region: PurR; COG1609
498217008503	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
498217008504	DNA binding site [nucleotide binding]
498217008505	domain linker motif; other site
498217008506	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
498217008507	dimerization interface (closed form) [polypeptide binding]; other site
498217008508	ligand binding site [chemical binding]; other site
498217008509	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
498217008510	4Fe-4S binding domain; Region: Fer4; cl02805
498217008511	formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042
498217008512	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
498217008513	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
498217008514	NADH dehydrogenase; Region: NADHdh; cl00469
498217008515	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
498217008516	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
498217008517	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
498217008518	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
498217008519	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
498217008520	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
498217008521	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
498217008522	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
498217008523	nickel binding site [ion binding]; other site
498217008524	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
498217008525	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
498217008526	molybdopterin cofactor binding site; other site
498217008527	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
498217008528	molybdopterin cofactor binding site; other site
498217008529	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
498217008530	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
498217008531	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
498217008532	Acylphosphatase; Region: Acylphosphatase; pfam00708
498217008533	HypF finger; Region: zf-HYPF; pfam07503
498217008534	HypF finger; Region: zf-HYPF; pfam07503
498217008535	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
498217008536	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
498217008537	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
498217008538	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
498217008539	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
498217008540	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
498217008541	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
498217008542	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
498217008543	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
498217008544	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
498217008545	dimerization interface [polypeptide binding]; other site
498217008546	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
498217008547	ATP binding site [chemical binding]; other site
498217008548	formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198
498217008549	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
498217008550	GAF domain; Region: GAF; pfam01590
498217008551	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217008552	Walker A motif; other site
498217008553	ATP binding site [chemical binding]; other site
498217008554	Walker B motif; other site
498217008555	arginine finger; other site
498217008556	diaminopimelate decarboxylase; Provisional; Region: PRK11165
498217008557	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
498217008558	active site
498217008559	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
498217008560	substrate binding site [chemical binding]; other site
498217008561	catalytic residues [active]
498217008562	dimer interface [polypeptide binding]; other site
498217008563	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
498217008564	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217008565	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
498217008566	dimerization interface [polypeptide binding]; other site
498217008567	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
498217008568	Sulfatase; Region: Sulfatase; cl17466
498217008569	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
498217008570	Autotransporter beta-domain; Region: Autotransporter; pfam03797
498217008571	Lyase, N terminal; Region: Lyase_N; pfam09092
498217008572	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
498217008573	substrate binding site [chemical binding]; other site
498217008574	catalytic residues [active]
498217008575	Lyase, N terminal; Region: Lyase_N; pfam09092
498217008576	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706
498217008577	substrate binding site [chemical binding]; other site
498217008578	catalytic residues [active]
498217008579	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
498217008580	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
498217008581	putative acyl-acceptor binding pocket; other site
498217008582	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
498217008583	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
498217008584	trimer interface [polypeptide binding]; other site
498217008585	Haemagglutinin; Region: HIM; pfam05662
498217008586	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
498217008587	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
498217008588	dimer interface [polypeptide binding]; other site
498217008589	putative anticodon binding site; other site
498217008590	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
498217008591	motif 1; other site
498217008592	active site
498217008593	motif 2; other site
498217008594	motif 3; other site
498217008595	This domain is found in peptide chain release factors; Region: PCRF; smart00937
498217008596	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
498217008597	RF-1 domain; Region: RF-1; pfam00472
498217008598	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
498217008599	DHH family; Region: DHH; pfam01368
498217008600	DHHA1 domain; Region: DHHA1; pfam02272
498217008601	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
498217008602	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
498217008603	dimerization domain [polypeptide binding]; other site
498217008604	dimer interface [polypeptide binding]; other site
498217008605	catalytic residues [active]
498217008606	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
498217008607	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
498217008608	active site
498217008609	Int/Topo IB signature motif; other site
498217008610	flavodoxin FldB; Provisional; Region: PRK12359
498217008611	Protein of unknown function (DUF1434); Region: DUF1434; pfam07254
498217008612	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
498217008613	putative global regulator; Reviewed; Region: PRK09559
498217008614	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
498217008615	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
498217008616	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
498217008617	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
498217008618	shikimate binding site; other site
498217008619	NAD(P) binding site [chemical binding]; other site
498217008620	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
498217008621	hemolysin; Provisional; Region: PRK15087
498217008622	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
498217008623	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
498217008624	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
498217008625	glycine dehydrogenase; Provisional; Region: PRK05367
498217008626	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
498217008627	tetramer interface [polypeptide binding]; other site
498217008628	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217008629	catalytic residue [active]
498217008630	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
498217008631	tetramer interface [polypeptide binding]; other site
498217008632	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217008633	catalytic residue [active]
498217008634	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
498217008635	lipoyl attachment site [posttranslational modification]; other site
498217008636	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
498217008637	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
498217008638	oxidoreductase; Provisional; Region: PRK08013
498217008639	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
498217008640	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
498217008641	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
498217008642	proline aminopeptidase P II; Provisional; Region: PRK10879
498217008643	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
498217008644	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
498217008645	active site
498217008646	hypothetical protein; Reviewed; Region: PRK01736
498217008647	Z-ring-associated protein; Provisional; Region: PRK10972
498217008648	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
498217008649	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
498217008650	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
498217008651	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
498217008652	ligand binding site [chemical binding]; other site
498217008653	NAD binding site [chemical binding]; other site
498217008654	tetramer interface [polypeptide binding]; other site
498217008655	catalytic site [active]
498217008656	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
498217008657	L-serine binding site [chemical binding]; other site
498217008658	ACT domain interface; other site
498217008659	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
498217008660	tetramer (dimer of dimers) interface [polypeptide binding]; other site
498217008661	active site
498217008662	dimer interface [polypeptide binding]; other site
498217008663	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
498217008664	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217008665	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
498217008666	putative dimerization interface [polypeptide binding]; other site
498217008667	oxidative stress defense protein; Provisional; Region: PRK11087
498217008668	Uncharacterized conserved protein [Function unknown]; Region: COG2968
498217008669	LysE type translocator; Region: LysE; cl00565
498217008670	mechanosensitive channel MscS; Provisional; Region: PRK10334
498217008671	Mechanosensitive ion channel; Region: MS_channel; pfam00924
498217008672	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
498217008673	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
498217008674	active site
498217008675	intersubunit interface [polypeptide binding]; other site
498217008676	zinc binding site [ion binding]; other site
498217008677	Na+ binding site [ion binding]; other site
498217008678	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
498217008679	Phosphoglycerate kinase; Region: PGK; pfam00162
498217008680	substrate binding site [chemical binding]; other site
498217008681	hinge regions; other site
498217008682	ADP binding site [chemical binding]; other site
498217008683	catalytic site [active]
498217008684	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
498217008685	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
498217008686	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
498217008687	transketolase; Reviewed; Region: PRK12753
498217008688	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
498217008689	TPP-binding site [chemical binding]; other site
498217008690	dimer interface [polypeptide binding]; other site
498217008691	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
498217008692	PYR/PP interface [polypeptide binding]; other site
498217008693	dimer interface [polypeptide binding]; other site
498217008694	TPP binding site [chemical binding]; other site
498217008695	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
498217008696	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
498217008697	Sulfatase; Region: Sulfatase; cl17466
498217008698	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
498217008699	agmatinase; Region: agmatinase; TIGR01230
498217008700	oligomer interface [polypeptide binding]; other site
498217008701	putative active site [active]
498217008702	Mn binding site [ion binding]; other site
498217008703	arginine decarboxylase; Provisional; Region: PRK05354
498217008704	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
498217008705	dimer interface [polypeptide binding]; other site
498217008706	active site
498217008707	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
498217008708	catalytic residues [active]
498217008709	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
498217008710	S-adenosylmethionine synthetase; Validated; Region: PRK05250
498217008711	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
498217008712	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
498217008713	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
498217008714	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
498217008715	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217008716	putative substrate translocation pore; other site
498217008717	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217008718	peptidase PmbA; Provisional; Region: PRK11040
498217008719	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
498217008720	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
498217008721	hypothetical protein; Provisional; Region: PRK05255
498217008722	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
498217008723	RNAase interaction site [polypeptide binding]; other site
498217008724	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
498217008725	active site
498217008726	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
498217008727	beta-galactosidase; Region: BGL; TIGR03356
498217008728	DctM-like transporters; Region: DctM; pfam06808
498217008729	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
498217008730	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
498217008731	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
498217008732	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
498217008733	cell density-dependent motility repressor; Provisional; Region: PRK10082
498217008734	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217008735	LysR substrate binding domain; Region: LysR_substrate; pfam03466
498217008736	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
498217008737	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
498217008738	active site
498217008739	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
498217008740	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
498217008741	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
498217008742	ligand binding site [chemical binding]; other site
498217008743	flexible hinge region; other site
498217008744	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
498217008745	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
498217008746	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
498217008747	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
498217008748	nucleoside transporter; Region: 2A0110; TIGR00889
498217008749	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217008750	putative substrate translocation pore; other site
498217008751	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
498217008752	short chain dehydrogenase; Provisional; Region: PRK07041
498217008753	NAD(P) binding site [chemical binding]; other site
498217008754	active site
498217008755	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498217008756	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217008757	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
498217008758	putative effector binding pocket; other site
498217008759	dimerization interface [polypeptide binding]; other site
498217008760	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
498217008761	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
498217008762	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
498217008763	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217008764	S-adenosylmethionine binding site [chemical binding]; other site
498217008765	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498217008766	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217008767	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
498217008768	dimerization interface [polypeptide binding]; other site
498217008769	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
498217008770	cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028
498217008771	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
498217008772	cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035
498217008773	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
498217008774	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
498217008775	Rubredoxin; Region: Rubredoxin; pfam00301
498217008776	iron binding site [ion binding]; other site
498217008777	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
498217008778	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
498217008779	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
498217008780	putative substrate-binding site; other site
498217008781	nickel binding site [ion binding]; other site
498217008782	hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171
498217008783	hydrogenase 1 large subunit; Provisional; Region: PRK10170
498217008784	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
498217008785	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
498217008786	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
498217008787	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
498217008788	potential frameshift: common BLAST hit: gi|238921268|ref|YP_002934783.1| Orn/Lys/Arg decarboxylase family
498217008789	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
498217008790	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
498217008791	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
498217008792	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
498217008793	catalytic residue [active]
498217008794	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
498217008795	putrescine transporter; Provisional; Region: potE; PRK10655
498217008796	lysine decarboxylase CadA; Provisional; Region: PRK15400
498217008797	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
498217008798	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
498217008799	homodimer interface [polypeptide binding]; other site
498217008800	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217008801	catalytic residue [active]
498217008802	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
498217008803	hypothetical protein; Provisional; Region: PRK09273
498217008804	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
498217008805	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
498217008806	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
498217008807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217008808	putative substrate translocation pore; other site
498217008809	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
498217008810	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217008811	active site
498217008812	phosphorylation site [posttranslational modification]
498217008813	intermolecular recognition site; other site
498217008814	dimerization interface [polypeptide binding]; other site
498217008815	LytTr DNA-binding domain; Region: LytTR; smart00850
498217008816	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
498217008817	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
498217008818	Histidine kinase; Region: His_kinase; pfam06580
498217008819	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217008820	ATP binding site [chemical binding]; other site
498217008821	Mg2+ binding site [ion binding]; other site
498217008822	G-X-G motif; other site
498217008823	alpha-galactosidase; Provisional; Region: PRK15076
498217008824	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
498217008825	NAD binding site [chemical binding]; other site
498217008826	sugar binding site [chemical binding]; other site
498217008827	divalent metal binding site [ion binding]; other site
498217008828	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
498217008829	dimer interface [polypeptide binding]; other site
498217008830	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
498217008831	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
498217008832	TM-ABC transporter signature motif; other site
498217008833	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
498217008834	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217008835	Walker A/P-loop; other site
498217008836	ATP binding site [chemical binding]; other site
498217008837	Q-loop/lid; other site
498217008838	ABC transporter signature motif; other site
498217008839	Walker B; other site
498217008840	D-loop; other site
498217008841	H-loop/switch region; other site
498217008842	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
498217008843	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
498217008844	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
498217008845	Protein of unknown function (DUF1045); Region: DUF1045; cl15435
498217008846	Periplasmic binding protein-like domain; Region: Peripla_BP_3; pfam13377
498217008847	putative outer membrane porin protein; Provisional; Region: PRK11379
498217008848	glucuronide transporter; Provisional; Region: PRK09848
498217008849	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
498217008850	beta-D-glucuronidase; Provisional; Region: PRK10150
498217008851	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
498217008852	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
498217008853	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
498217008854	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
498217008855	TrkA-N domain; Region: TrkA_N; pfam02254
498217008856	Transcriptional regulators [Transcription]; Region: PurR; COG1609
498217008857	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
498217008858	DNA binding site [nucleotide binding]
498217008859	domain linker motif; other site
498217008860	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
498217008861	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498217008862	active site
498217008863	phosphorylation site [posttranslational modification]
498217008864	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
498217008865	active site
498217008866	P-loop; other site
498217008867	phosphorylation site [posttranslational modification]
498217008868	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
498217008869	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
498217008870	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217008871	motif II; other site
498217008872	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
498217008873	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
498217008874	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
498217008875	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
498217008876	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
498217008877	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
498217008878	active site
498217008879	DNA binding site [nucleotide binding]
498217008880	Int/Topo IB signature motif; other site
498217008881	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
498217008882	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
498217008883	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498217008884	DNA binding site [nucleotide binding]
498217008885	Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395
498217008886	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185
498217008887	Autotransporter beta-domain; Region: Autotransporter; cl17461
498217008888	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
498217008889	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
498217008890	amidase catalytic site [active]
498217008891	Zn binding residues [ion binding]; other site
498217008892	substrate binding site [chemical binding]; other site
498217008893	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
498217008894	chorismate mutase; Provisional; Region: PRK08055
498217008895	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
498217008896	transposase/IS protein; Provisional; Region: PRK09183
498217008897	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217008898	Walker A motif; other site
498217008899	ATP binding site [chemical binding]; other site
498217008900	Walker B motif; other site
498217008901	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
498217008902	Helix-turn-helix domain; Region: HTH_38; pfam13936
498217008903	Integrase core domain; Region: rve; pfam00665
498217008904	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
498217008905	active site
498217008906	metal binding site [ion binding]; metal-binding site
498217008907	interdomain interaction site; other site
498217008908	D5 N terminal like; Region: D5_N; smart00885
498217008909	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
498217008910	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
498217008911	Domain of unknown function (DUF1870); Region: DUF1870; pfam08965
498217008912	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
498217008913	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
498217008914	active site
498217008915	catalytic site [active]
498217008916	substrate binding site [chemical binding]; other site
498217008917	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
498217008918	Helix-turn-helix domain; Region: HTH_38; pfam13936
498217008919	Integrase core domain; Region: rve; pfam00665
498217008920	transposase/IS protein; Provisional; Region: PRK09183
498217008921	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217008922	Walker A motif; other site
498217008923	ATP binding site [chemical binding]; other site
498217008924	Walker B motif; other site
498217008925	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
498217008926	HsdM N-terminal domain; Region: HsdM_N; pfam12161
498217008927	Methyltransferase domain; Region: Methyltransf_26; pfam13659
498217008928	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
498217008929	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
498217008930	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
498217008931	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
498217008932	ADP-ribose binding site [chemical binding]; other site
498217008933	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
498217008934	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
498217008935	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
498217008936	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498217008937	ATP binding site [chemical binding]; other site
498217008938	putative Mg++ binding site [ion binding]; other site
498217008939	Protein of unknown function DUF45; Region: DUF45; pfam01863
498217008940	Helix-turn-helix domain; Region: HTH_38; pfam13936
498217008941	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498217008942	Integrase core domain; Region: rve; pfam00665
498217008943	Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012
498217008944	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
498217008945	Helix-turn-helix domain; Region: HTH_36; pfam13730
498217008946	tRNA_anti-like; Region: tRNA_anti-like; pfam12869
498217008947	transposase/IS protein; Provisional; Region: PRK09183
498217008948	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217008949	Walker A motif; other site
498217008950	ATP binding site [chemical binding]; other site
498217008951	Walker B motif; other site
498217008952	Phage polarity suppression protein (Psu); Region: Psu; pfam07455
498217008953	Domain of unknown function (DUF4297); Region: DUF4297; pfam14130
498217008954	integrase; Provisional; Region: PRK09692
498217008955	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
498217008956	active site
498217008957	Int/Topo IB signature motif; other site
498217008958	L,D-transpeptidase; Provisional; Region: PRK10260
498217008959	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
498217008960	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
498217008961	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
498217008962	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
498217008963	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
498217008964	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
498217008965	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
498217008966	multifunctional aminopeptidase A; Provisional; Region: PRK00913
498217008967	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
498217008968	interface (dimer of trimers) [polypeptide binding]; other site
498217008969	Substrate-binding/catalytic site; other site
498217008970	Zn-binding sites [ion binding]; other site
498217008971	DNA polymerase III subunit chi; Validated; Region: PRK05728
498217008972	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
498217008973	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
498217008974	HIGH motif; other site
498217008975	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
498217008976	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
498217008977	active site
498217008978	KMSKS motif; other site
498217008979	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
498217008980	tRNA binding surface [nucleotide binding]; other site
498217008981	anticodon binding site; other site
498217008982	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
498217008983	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
498217008984	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217008985	dimer interface [polypeptide binding]; other site
498217008986	conserved gate region; other site
498217008987	putative PBP binding loops; other site
498217008988	ABC-ATPase subunit interface; other site
498217008989	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
498217008990	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
498217008991	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
498217008992	Walker A/P-loop; other site
498217008993	ATP binding site [chemical binding]; other site
498217008994	Q-loop/lid; other site
498217008995	ABC transporter signature motif; other site
498217008996	Walker B; other site
498217008997	D-loop; other site
498217008998	H-loop/switch region; other site
498217008999	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
498217009000	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
498217009001	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
498217009002	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
498217009003	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
498217009004	dimer interface [polypeptide binding]; other site
498217009005	active site
498217009006	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
498217009007	substrate binding site [chemical binding]; other site
498217009008	catalytic residue [active]
498217009009	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
498217009010	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
498217009011	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
498217009012	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
498217009013	catalytic residue [active]
498217009014	PAS fold; Region: PAS_4; pfam08448
498217009015	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
498217009016	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217009017	Walker A motif; other site
498217009018	ATP binding site [chemical binding]; other site
498217009019	Walker B motif; other site
498217009020	arginine finger; other site
498217009021	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
498217009022	RNase E inhibitor protein; Provisional; Region: PRK11191
498217009023	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
498217009024	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
498217009025	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
498217009026	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
498217009027	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
498217009028	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
498217009029	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
498217009030	Cysteine-rich domain; Region: CCG; pfam02754
498217009031	Cysteine-rich domain; Region: CCG; pfam02754
498217009032	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
498217009033	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
498217009034	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
498217009035	hydroxyglutarate oxidase; Provisional; Region: PRK11728
498217009036	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
498217009037	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
498217009038	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217009039	putative substrate translocation pore; other site
498217009040	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
498217009041	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
498217009042	active site
498217009043	catalytic site [active]
498217009044	metal binding site [ion binding]; metal-binding site
498217009045	putative glutathione S-transferase; Provisional; Region: PRK10357
498217009046	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
498217009047	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
498217009048	dimer interface [polypeptide binding]; other site
498217009049	N-terminal domain interface [polypeptide binding]; other site
498217009050	putative substrate binding pocket (H-site) [chemical binding]; other site
498217009051	selenocysteine synthase; Provisional; Region: PRK04311
498217009052	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
498217009053	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
498217009054	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
498217009055	catalytic residue [active]
498217009056	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
498217009057	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
498217009058	G1 box; other site
498217009059	putative GEF interaction site [polypeptide binding]; other site
498217009060	GTP/Mg2+ binding site [chemical binding]; other site
498217009061	Switch I region; other site
498217009062	G2 box; other site
498217009063	G3 box; other site
498217009064	Switch II region; other site
498217009065	G4 box; other site
498217009066	G5 box; other site
498217009067	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
498217009068	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
498217009069	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
498217009070	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
498217009071	voltage-gated potassium channel; Provisional; Region: PRK10537
498217009072	Ion channel; Region: Ion_trans_2; pfam07885
498217009073	TrkA-N domain; Region: TrkA_N; pfam02254
498217009074	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
498217009075	homotrimer interaction site [polypeptide binding]; other site
498217009076	putative active site [active]
498217009077	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
498217009078	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
498217009079	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
498217009080	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
498217009081	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
498217009082	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
498217009083	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
498217009084	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
498217009085	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
498217009086	HlyD family secretion protein; Region: HlyD_3; pfam13437
498217009087	efflux system membrane protein; Provisional; Region: PRK11594
498217009088	transcriptional regulator; Provisional; Region: PRK10632
498217009089	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217009090	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
498217009091	putative effector binding pocket; other site
498217009092	dimerization interface [polypeptide binding]; other site
498217009093	protease TldD; Provisional; Region: tldD; PRK10735
498217009094	nitrilase; Region: PLN02798
498217009095	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
498217009096	putative active site [active]
498217009097	catalytic triad [active]
498217009098	dimer interface [polypeptide binding]; other site
498217009099	hypothetical protein; Provisional; Region: PRK10899
498217009100	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
498217009101	ribonuclease G; Provisional; Region: PRK11712
498217009102	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
498217009103	homodimer interface [polypeptide binding]; other site
498217009104	oligonucleotide binding site [chemical binding]; other site
498217009105	Maf-like protein; Region: Maf; pfam02545
498217009106	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
498217009107	active site
498217009108	dimer interface [polypeptide binding]; other site
498217009109	rod shape-determining protein MreD; Provisional; Region: PRK11060
498217009110	rod shape-determining protein MreC; Region: MreC; pfam04085
498217009111	rod shape-determining protein MreB; Provisional; Region: PRK13927
498217009112	MreB and similar proteins; Region: MreB_like; cd10225
498217009113	nucleotide binding site [chemical binding]; other site
498217009114	Mg binding site [ion binding]; other site
498217009115	putative protofilament interaction site [polypeptide binding]; other site
498217009116	RodZ interaction site [polypeptide binding]; other site
498217009117	regulatory protein CsrD; Provisional; Region: PRK11059
498217009118	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
498217009119	metal binding site [ion binding]; metal-binding site
498217009120	I-site; other site
498217009121	active site
498217009122	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
498217009123	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
498217009124	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
498217009125	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
498217009126	NADP binding site [chemical binding]; other site
498217009127	dimer interface [polypeptide binding]; other site
498217009128	TMAO/DMSO reductase; Reviewed; Region: PRK05363
498217009129	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
498217009130	Moco binding site; other site
498217009131	metal coordination site [ion binding]; other site
498217009132	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
498217009133	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
498217009134	Dehydroquinase class II; Region: DHquinase_II; pfam01220
498217009135	active site
498217009136	trimer interface [polypeptide binding]; other site
498217009137	dimer interface [polypeptide binding]; other site
498217009138	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
498217009139	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
498217009140	carboxyltransferase (CT) interaction site; other site
498217009141	biotinylation site [posttranslational modification]; other site
498217009142	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
498217009143	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
498217009144	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
498217009145	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
498217009146	hypothetical protein; Provisional; Region: PRK10633
498217009147	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
498217009148	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
498217009149	Na binding site [ion binding]; other site
498217009150	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
498217009151	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
498217009152	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
498217009153	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
498217009154	FMN binding site [chemical binding]; other site
498217009155	active site
498217009156	catalytic residues [active]
498217009157	substrate binding site [chemical binding]; other site
498217009158	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
498217009159	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
498217009160	Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1888
498217009161	hypothetical protein; Provisional; Region: PRK10556
498217009162	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
498217009163	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
498217009164	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498217009165	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217009166	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
498217009167	putative dimerization interface [polypeptide binding]; other site
498217009168	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
498217009169	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
498217009170	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
498217009171	guanine deaminase; Provisional; Region: PRK09228
498217009172	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
498217009173	active site
498217009174	xanthine permease; Region: pbuX; TIGR03173
498217009175	putative hypoxanthine oxidase; Provisional; Region: PRK09800
498217009176	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
498217009177	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
498217009178	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
498217009179	putative oxidoreductase; Provisional; Region: PRK09799
498217009180	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
498217009181	putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203
498217009182	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
498217009183	active site
498217009184	putative selenate reductase subunit YgfK; Provisional; Region: PRK09853
498217009185	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
498217009186	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
498217009187	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498217009188	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
498217009189	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
498217009190	Ligand binding site; other site
498217009191	metal-binding site
498217009192	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
498217009193	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
498217009194	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
498217009195	XdhC Rossmann domain; Region: XdhC_C; pfam13478
498217009196	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
498217009197	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
498217009198	carbamate kinase; Reviewed; Region: PRK12686
498217009199	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
498217009200	putative substrate binding site [chemical binding]; other site
498217009201	homodimer interface [polypeptide binding]; other site
498217009202	nucleotide binding site [chemical binding]; other site
498217009203	nucleotide binding site [chemical binding]; other site
498217009204	phenylhydantoinase; Validated; Region: PRK08323
498217009205	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
498217009206	tetramer interface [polypeptide binding]; other site
498217009207	active site
498217009208	peptidase; Reviewed; Region: PRK13004
498217009209	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649
498217009210	putative metal binding site [ion binding]; other site
498217009211	putative dimer interface [polypeptide binding]; other site
498217009212	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
498217009213	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
498217009214	catalytic residue [active]
498217009215	aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200
498217009216	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
498217009217	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
498217009218	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
498217009219	GAF domain; Region: GAF; cl17456
498217009220	PAS domain; Region: PAS; smart00091
498217009221	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217009222	Walker A motif; other site
498217009223	ATP binding site [chemical binding]; other site
498217009224	Walker B motif; other site
498217009225	arginine finger; other site
498217009226	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
498217009227	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
498217009228	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
498217009229	dimer interface [polypeptide binding]; other site
498217009230	ssDNA binding site [nucleotide binding]; other site
498217009231	tetramer (dimer of dimers) interface [polypeptide binding]; other site
498217009232	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
498217009233	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
498217009234	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
498217009235	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
498217009236	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
498217009237	Uncharacterized conserved protein [Function unknown]; Region: COG0432
498217009238	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
498217009239	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
498217009240	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217009241	homodimer interface [polypeptide binding]; other site
498217009242	catalytic residue [active]
498217009243	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
498217009244	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
498217009245	active site
498217009246	catalytic tetrad [active]
498217009247	hypothetical protein; Provisional; Region: PRK01254
498217009248	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
498217009249	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
498217009250	homoserine O-succinyltransferase; Provisional; Region: PRK05368
498217009251	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
498217009252	proposed active site lysine [active]
498217009253	conserved cys residue [active]
498217009254	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
498217009255	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
498217009256	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
498217009257	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
498217009258	trimer interface [polypeptide binding]; other site
498217009259	putative metal binding site [ion binding]; other site
498217009260	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
498217009261	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
498217009262	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
498217009263	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
498217009264	shikimate binding site; other site
498217009265	NAD(P) binding site [chemical binding]; other site
498217009266	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
498217009267	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
498217009268	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
498217009269	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
498217009270	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
498217009271	Protein of unknown function (DUF494); Region: DUF494; cl01103
498217009272	hypothetical protein; Provisional; Region: PRK10736
498217009273	DNA protecting protein DprA; Region: dprA; TIGR00732
498217009274	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
498217009275	active site
498217009276	catalytic residues [active]
498217009277	metal binding site [ion binding]; metal-binding site
498217009278	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
498217009279	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
498217009280	putative active site [active]
498217009281	substrate binding site [chemical binding]; other site
498217009282	putative cosubstrate binding site; other site
498217009283	catalytic site [active]
498217009284	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
498217009285	substrate binding site [chemical binding]; other site
498217009286	16S rRNA methyltransferase B; Provisional; Region: PRK10901
498217009287	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
498217009288	putative RNA binding site [nucleotide binding]; other site
498217009289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217009290	S-adenosylmethionine binding site [chemical binding]; other site
498217009291	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
498217009292	TrkA-N domain; Region: TrkA_N; pfam02254
498217009293	TrkA-C domain; Region: TrkA_C; pfam02080
498217009294	TrkA-N domain; Region: TrkA_N; pfam02254
498217009295	TrkA-C domain; Region: TrkA_C; pfam02080
498217009296	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
498217009297	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
498217009298	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
498217009299	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
498217009300	Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043
498217009301	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
498217009302	DNA binding residues [nucleotide binding]
498217009303	dimer interface [polypeptide binding]; other site
498217009304	metal binding site [ion binding]; metal-binding site
498217009305	hypothetical protein; Provisional; Region: PRK10203
498217009306	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
498217009307	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
498217009308	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
498217009309	alphaNTD homodimer interface [polypeptide binding]; other site
498217009310	alphaNTD - beta interaction site [polypeptide binding]; other site
498217009311	alphaNTD - beta' interaction site [polypeptide binding]; other site
498217009312	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
498217009313	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
498217009314	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
498217009315	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
498217009316	RNA binding surface [nucleotide binding]; other site
498217009317	30S ribosomal protein S11; Validated; Region: PRK05309
498217009318	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
498217009319	30S ribosomal protein S13; Region: bact_S13; TIGR03631
498217009320	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
498217009321	SecY translocase; Region: SecY; pfam00344
498217009322	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
498217009323	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
498217009324	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
498217009325	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
498217009326	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
498217009327	23S rRNA interface [nucleotide binding]; other site
498217009328	5S rRNA interface [nucleotide binding]; other site
498217009329	L27 interface [polypeptide binding]; other site
498217009330	L5 interface [polypeptide binding]; other site
498217009331	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
498217009332	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
498217009333	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
498217009334	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
498217009335	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
498217009336	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
498217009337	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
498217009338	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
498217009339	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
498217009340	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
498217009341	RNA binding site [nucleotide binding]; other site
498217009342	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
498217009343	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
498217009344	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
498217009345	23S rRNA interface [nucleotide binding]; other site
498217009346	putative translocon interaction site; other site
498217009347	signal recognition particle (SRP54) interaction site; other site
498217009348	L23 interface [polypeptide binding]; other site
498217009349	trigger factor interaction site; other site
498217009350	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
498217009351	23S rRNA interface [nucleotide binding]; other site
498217009352	5S rRNA interface [nucleotide binding]; other site
498217009353	putative antibiotic binding site [chemical binding]; other site
498217009354	L25 interface [polypeptide binding]; other site
498217009355	L27 interface [polypeptide binding]; other site
498217009356	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
498217009357	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
498217009358	G-X-X-G motif; other site
498217009359	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
498217009360	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
498217009361	protein-rRNA interface [nucleotide binding]; other site
498217009362	putative translocon binding site; other site
498217009363	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
498217009364	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
498217009365	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
498217009366	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
498217009367	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
498217009368	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
498217009369	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
498217009370	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
498217009371	elongation factor Tu; Reviewed; Region: PRK00049
498217009372	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
498217009373	G1 box; other site
498217009374	GEF interaction site [polypeptide binding]; other site
498217009375	GTP/Mg2+ binding site [chemical binding]; other site
498217009376	Switch I region; other site
498217009377	G2 box; other site
498217009378	G3 box; other site
498217009379	Switch II region; other site
498217009380	G4 box; other site
498217009381	G5 box; other site
498217009382	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
498217009383	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
498217009384	Antibiotic Binding Site [chemical binding]; other site
498217009385	elongation factor G; Reviewed; Region: PRK00007
498217009386	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
498217009387	G1 box; other site
498217009388	putative GEF interaction site [polypeptide binding]; other site
498217009389	GTP/Mg2+ binding site [chemical binding]; other site
498217009390	Switch I region; other site
498217009391	G2 box; other site
498217009392	G3 box; other site
498217009393	Switch II region; other site
498217009394	G4 box; other site
498217009395	G5 box; other site
498217009396	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
498217009397	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
498217009398	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
498217009399	30S ribosomal protein S7; Validated; Region: PRK05302
498217009400	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
498217009401	S17 interaction site [polypeptide binding]; other site
498217009402	S8 interaction site; other site
498217009403	16S rRNA interaction site [nucleotide binding]; other site
498217009404	streptomycin interaction site [chemical binding]; other site
498217009405	23S rRNA interaction site [nucleotide binding]; other site
498217009406	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
498217009407	DsrH like protein; Region: DsrH; cl17347
498217009408	sulfur relay protein TusC; Validated; Region: PRK00211
498217009409	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
498217009410	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
498217009411	YheO-like PAS domain; Region: PAS_6; pfam08348
498217009412	HTH domain; Region: HTH_22; pfam13309
498217009413	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
498217009414	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
498217009415	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
498217009416	phi X174 lysis protein; Provisional; Region: PRK02793
498217009417	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
498217009418	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
498217009419	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
498217009420	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
498217009421	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
498217009422	TrkA-N domain; Region: TrkA_N; pfam02254
498217009423	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
498217009424	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
498217009425	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217009426	Walker A/P-loop; other site
498217009427	ATP binding site [chemical binding]; other site
498217009428	Q-loop/lid; other site
498217009429	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498217009430	ABC transporter; Region: ABC_tran_2; pfam12848
498217009431	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
498217009432	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
498217009433	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
498217009434	inhibitor-cofactor binding pocket; inhibition site
498217009435	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217009436	catalytic residue [active]
498217009437	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
498217009438	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
498217009439	glutamine binding [chemical binding]; other site
498217009440	catalytic triad [active]
498217009441	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
498217009442	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
498217009443	substrate binding site [chemical binding]; other site
498217009444	putative transporter; Provisional; Region: PRK03699
498217009445	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217009446	putative substrate translocation pore; other site
498217009447	cytosine deaminase; Provisional; Region: PRK09230
498217009448	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
498217009449	active site
498217009450	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
498217009451	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
498217009452	Na binding site [ion binding]; other site
498217009453	putative substrate binding site [chemical binding]; other site
498217009454	siroheme synthase; Provisional; Region: cysG; PRK10637
498217009455	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
498217009456	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
498217009457	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
498217009458	active site
498217009459	SAM binding site [chemical binding]; other site
498217009460	homodimer interface [polypeptide binding]; other site
498217009461	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
498217009462	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
498217009463	active site
498217009464	HIGH motif; other site
498217009465	dimer interface [polypeptide binding]; other site
498217009466	KMSKS motif; other site
498217009467	phosphoglycolate phosphatase; Provisional; Region: PRK13222
498217009468	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
498217009469	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217009470	motif II; other site
498217009471	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
498217009472	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
498217009473	substrate binding site [chemical binding]; other site
498217009474	hexamer interface [polypeptide binding]; other site
498217009475	metal binding site [ion binding]; metal-binding site
498217009476	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
498217009477	hypothetical protein; Reviewed; Region: PRK11901
498217009478	cell division protein DamX; Validated; Region: PRK10905
498217009479	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
498217009480	active site
498217009481	dimer interface [polypeptide binding]; other site
498217009482	metal binding site [ion binding]; metal-binding site
498217009483	shikimate kinase; Reviewed; Region: aroK; PRK00131
498217009484	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
498217009485	ADP binding site [chemical binding]; other site
498217009486	magnesium binding site [ion binding]; other site
498217009487	putative shikimate binding site; other site
498217009488	putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568
498217009489	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
498217009490	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
498217009491	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
498217009492	Transglycosylase; Region: Transgly; pfam00912
498217009493	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
498217009494	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
498217009495	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
498217009496	ADP-ribose binding site [chemical binding]; other site
498217009497	dimer interface [polypeptide binding]; other site
498217009498	active site
498217009499	nudix motif; other site
498217009500	metal binding site [ion binding]; metal-binding site
498217009501	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
498217009502	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
498217009503	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217009504	motif II; other site
498217009505	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
498217009506	RNA binding surface [nucleotide binding]; other site
498217009507	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
498217009508	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
498217009509	dimerization interface [polypeptide binding]; other site
498217009510	domain crossover interface; other site
498217009511	redox-dependent activation switch; other site
498217009512	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
498217009513	thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006
498217009514	cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146
498217009515	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
498217009516	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
498217009517	active site residue [active]
498217009518	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
498217009519	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
498217009520	active site
498217009521	substrate-binding site [chemical binding]; other site
498217009522	metal-binding site [ion binding]
498217009523	ATP binding site [chemical binding]; other site
498217009524	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
498217009525	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
498217009526	dimerization interface [polypeptide binding]; other site
498217009527	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217009528	dimer interface [polypeptide binding]; other site
498217009529	phosphorylation site [posttranslational modification]
498217009530	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217009531	ATP binding site [chemical binding]; other site
498217009532	Mg2+ binding site [ion binding]; other site
498217009533	G-X-G motif; other site
498217009534	osmolarity response regulator; Provisional; Region: ompR; PRK09468
498217009535	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217009536	active site
498217009537	phosphorylation site [posttranslational modification]
498217009538	intermolecular recognition site; other site
498217009539	dimerization interface [polypeptide binding]; other site
498217009540	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498217009541	DNA binding site [nucleotide binding]
498217009542	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
498217009543	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
498217009544	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
498217009545	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
498217009546	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
498217009547	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
498217009548	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
498217009549	RNA binding site [nucleotide binding]; other site
498217009550	ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555
498217009551	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
498217009552	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
498217009553	G1 box; other site
498217009554	GTP/Mg2+ binding site [chemical binding]; other site
498217009555	Switch I region; other site
498217009556	G2 box; other site
498217009557	G3 box; other site
498217009558	Switch II region; other site
498217009559	G4 box; other site
498217009560	G5 box; other site
498217009561	Nucleoside recognition; Region: Gate; pfam07670
498217009562	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
498217009563	Nucleoside recognition; Region: Gate; pfam07670
498217009564	FeoC like transcriptional regulator; Region: FeoC; cl17677
498217009565	carboxylesterase BioH; Provisional; Region: PRK10349
498217009566	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
498217009567	DNA utilization protein GntX; Provisional; Region: PRK11595
498217009568	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498217009569	active site
498217009570	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
498217009571	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
498217009572	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
498217009573	transcriptional repressor UlaR; Provisional; Region: PRK13509
498217009574	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
498217009575	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498217009576	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
498217009577	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
498217009578	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
498217009579	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
498217009580	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
498217009581	active site
498217009582	phosphorylation site [posttranslational modification]
498217009583	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
498217009584	active site
498217009585	dimer interface [polypeptide binding]; other site
498217009586	magnesium binding site [ion binding]; other site
498217009587	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
498217009588	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
498217009589	AP (apurinic/apyrimidinic) site pocket; other site
498217009590	DNA interaction; other site
498217009591	Metal-binding active site; metal-binding site
498217009592	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
498217009593	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
498217009594	intersubunit interface [polypeptide binding]; other site
498217009595	active site
498217009596	Zn2+ binding site [ion binding]; other site
498217009597	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
498217009598	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
498217009599	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
498217009600	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
498217009601	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
498217009602	ligand binding site [chemical binding]; other site
498217009603	flexible hinge region; other site
498217009604	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
498217009605	putative switch regulator; other site
498217009606	non-specific DNA interactions [nucleotide binding]; other site
498217009607	DNA binding site [nucleotide binding]
498217009608	sequence specific DNA binding site [nucleotide binding]; other site
498217009609	putative cAMP binding site [chemical binding]; other site
498217009610	hypothetical protein; Provisional; Region: PRK04966
498217009611	putative hydrolase; Provisional; Region: PRK10985
498217009612	N terminus of Rad21 / Rec8 like protein; Region: Rad21_Rec8_N; pfam04825
498217009613	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
498217009614	transcriptional regulator MalT; Provisional; Region: PRK04841
498217009615	AAA ATPase domain; Region: AAA_16; pfam13191
498217009616	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
498217009617	DNA binding residues [nucleotide binding]
498217009618	dimerization interface [polypeptide binding]; other site
498217009619	maltodextrin phosphorylase; Provisional; Region: PRK14985
498217009620	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
498217009621	homodimer interface [polypeptide binding]; other site
498217009622	active site pocket [active]
498217009623	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
498217009624	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
498217009625	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
498217009626	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
498217009627	ligand binding site; other site
498217009628	oligomer interface; other site
498217009629	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
498217009630	N-terminal domain interface [polypeptide binding]; other site
498217009631	sulfate 1 binding site; other site
498217009632	glycogen branching enzyme; Provisional; Region: PRK05402
498217009633	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
498217009634	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
498217009635	active site
498217009636	catalytic site [active]
498217009637	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
498217009638	glycogen debranching enzyme; Provisional; Region: PRK03705
498217009639	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
498217009640	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
498217009641	active site
498217009642	catalytic site [active]
498217009643	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
498217009644	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
498217009645	ligand binding site; other site
498217009646	oligomer interface; other site
498217009647	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
498217009648	dimer interface [polypeptide binding]; other site
498217009649	N-terminal domain interface [polypeptide binding]; other site
498217009650	sulfate 1 binding site; other site
498217009651	glycogen synthase; Provisional; Region: glgA; PRK00654
498217009652	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
498217009653	ADP-binding pocket [chemical binding]; other site
498217009654	homodimer interface [polypeptide binding]; other site
498217009655	glycogen phosphorylase; Provisional; Region: PRK14986
498217009656	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
498217009657	homodimer interface [polypeptide binding]; other site
498217009658	active site pocket [active]
498217009659	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
498217009660	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
498217009661	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
498217009662	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
498217009663	intramembrane serine protease GlpG; Provisional; Region: PRK10907
498217009664	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
498217009665	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
498217009666	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
498217009667	active site residue [active]
498217009668	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
498217009669	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
498217009670	putative active site [active]
498217009671	catalytic site [active]
498217009672	putative metal binding site [ion binding]; other site
498217009673	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
498217009674	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
498217009675	Walker A/P-loop; other site
498217009676	ATP binding site [chemical binding]; other site
498217009677	Q-loop/lid; other site
498217009678	ABC transporter signature motif; other site
498217009679	Walker B; other site
498217009680	D-loop; other site
498217009681	H-loop/switch region; other site
498217009682	TOBE domain; Region: TOBE_2; pfam08402
498217009683	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
498217009684	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217009685	dimer interface [polypeptide binding]; other site
498217009686	conserved gate region; other site
498217009687	putative PBP binding loops; other site
498217009688	ABC-ATPase subunit interface; other site
498217009689	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
498217009690	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217009691	dimer interface [polypeptide binding]; other site
498217009692	conserved gate region; other site
498217009693	putative PBP binding loops; other site
498217009694	ABC-ATPase subunit interface; other site
498217009695	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
498217009696	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
498217009697	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
498217009698	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
498217009699	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
498217009700	fructuronate transporter; Provisional; Region: PRK10034; cl15264
498217009701	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
498217009702	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
498217009703	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
498217009704	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
498217009705	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
498217009706	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
498217009707	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
498217009708	DNA binding residues [nucleotide binding]
498217009709	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
498217009710	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
498217009711	cell division protein FtsE; Provisional; Region: PRK10908
498217009712	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
498217009713	Walker A/P-loop; other site
498217009714	ATP binding site [chemical binding]; other site
498217009715	Q-loop/lid; other site
498217009716	ABC transporter signature motif; other site
498217009717	Walker B; other site
498217009718	D-loop; other site
498217009719	H-loop/switch region; other site
498217009720	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
498217009721	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
498217009722	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
498217009723	P loop; other site
498217009724	GTP binding site [chemical binding]; other site
498217009725	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
498217009726	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217009727	S-adenosylmethionine binding site [chemical binding]; other site
498217009728	hypothetical protein; Provisional; Region: PRK10910
498217009729	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
498217009730	Domain of unknown function (DUF1820); Region: DUF1820; pfam08850
498217009731	Predicted membrane protein [Function unknown]; Region: COG3714
498217009732	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
498217009733	MOSC domain; Region: MOSC; pfam03473
498217009734	3-alpha domain; Region: 3-alpha; pfam03475
498217009735	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
498217009736	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
498217009737	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
498217009738	molybdopterin cofactor binding site; other site
498217009739	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
498217009740	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
498217009741	molybdopterin cofactor binding site; other site
498217009742	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
498217009743	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
498217009744	formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179
498217009745	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
498217009746	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
498217009747	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
498217009748	putative hydrolase; Provisional; Region: PRK10976
498217009749	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217009750	active site
498217009751	motif I; other site
498217009752	motif II; other site
498217009753	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
498217009754	lysophospholipase L2; Provisional; Region: PRK10749
498217009755	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
498217009756	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
498217009757	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
498217009758	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
498217009759	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
498217009760	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
498217009761	Histidine kinase; Region: His_kinase; pfam06580
498217009762	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217009763	ATP binding site [chemical binding]; other site
498217009764	Mg2+ binding site [ion binding]; other site
498217009765	G-X-G motif; other site
498217009766	magnesium-transporting ATPase; Provisional; Region: PRK15122
498217009767	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
498217009768	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
498217009769	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
498217009770	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217009771	motif II; other site
498217009772	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
498217009773	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
498217009774	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
498217009775	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
498217009776	Na2 binding site [ion binding]; other site
498217009777	putative substrate binding site 1 [chemical binding]; other site
498217009778	Na binding site 1 [ion binding]; other site
498217009779	putative substrate binding site 2 [chemical binding]; other site
498217009780	universal stress protein UspB; Provisional; Region: PRK04960
498217009781	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
498217009782	Ligand Binding Site [chemical binding]; other site
498217009783	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
498217009784	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217009785	putative substrate translocation pore; other site
498217009786	POT family; Region: PTR2; pfam00854
498217009787	glutamate dehydrogenase; Provisional; Region: PRK09414
498217009788	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
498217009789	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
498217009790	NAD(P) binding site [chemical binding]; other site
498217009791	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
498217009792	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
498217009793	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217009794	dimer interface [polypeptide binding]; other site
498217009795	phosphorylation site [posttranslational modification]
498217009796	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217009797	ATP binding site [chemical binding]; other site
498217009798	Mg2+ binding site [ion binding]; other site
498217009799	G-X-G motif; other site
498217009800	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
498217009801	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217009802	active site
498217009803	phosphorylation site [posttranslational modification]
498217009804	intermolecular recognition site; other site
498217009805	dimerization interface [polypeptide binding]; other site
498217009806	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498217009807	DNA binding site [nucleotide binding]
498217009808	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
498217009809	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
498217009810	ligand binding site [chemical binding]; other site
498217009811	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
498217009812	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
498217009813	Walker A/P-loop; other site
498217009814	ATP binding site [chemical binding]; other site
498217009815	Q-loop/lid; other site
498217009816	ABC transporter signature motif; other site
498217009817	Walker B; other site
498217009818	D-loop; other site
498217009819	H-loop/switch region; other site
498217009820	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
498217009821	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
498217009822	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
498217009823	TM-ABC transporter signature motif; other site
498217009824	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
498217009825	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
498217009826	TM-ABC transporter signature motif; other site
498217009827	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
498217009828	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
498217009829	N- and C-terminal domain interface [polypeptide binding]; other site
498217009830	active site
498217009831	MgATP binding site [chemical binding]; other site
498217009832	catalytic site [active]
498217009833	metal binding site [ion binding]; metal-binding site
498217009834	carbohydrate binding site [chemical binding]; other site
498217009835	putative homodimer interface [polypeptide binding]; other site
498217009836	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
498217009837	putative active site [active]
498217009838	putative methyltransferase; Provisional; Region: PRK10742
498217009839	oligopeptidase A; Provisional; Region: PRK10911
498217009840	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
498217009841	active site
498217009842	Zn binding site [ion binding]; other site
498217009843	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
498217009844	nucleotide binding site/active site [active]
498217009845	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
498217009846	glutathione reductase; Validated; Region: PRK06116
498217009847	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
498217009848	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498217009849	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
498217009850	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
498217009851	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
498217009852	dimer interface [polypeptide binding]; other site
498217009853	ligand binding site [chemical binding]; other site
498217009854	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
498217009855	dimerization interface [polypeptide binding]; other site
498217009856	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
498217009857	dimer interface [polypeptide binding]; other site
498217009858	putative CheW interface [polypeptide binding]; other site
498217009859	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
498217009860	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
498217009861	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
498217009862	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
498217009863	Transcriptional regulator [Transcription]; Region: LysR; COG0583
498217009864	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217009865	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
498217009866	CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471
498217009867	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
498217009868	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
498217009869	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
498217009870	substrate binding site [chemical binding]; other site
498217009871	ATP binding site [chemical binding]; other site
498217009872	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
498217009873	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
498217009874	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
498217009875	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
498217009876	biofilm formation regulator HmsP; Provisional; Region: PRK11829
498217009877	HAMP domain; Region: HAMP; pfam00672
498217009878	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
498217009879	metal binding site [ion binding]; metal-binding site
498217009880	active site
498217009881	I-site; other site
498217009882	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
498217009883	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
498217009884	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
498217009885	binding surface
498217009886	TPR motif; other site
498217009887	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
498217009888	TPR motif; other site
498217009889	binding surface
498217009890	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
498217009891	endo-1,4-D-glucanase; Provisional; Region: PRK11097
498217009892	cellulose synthase regulator protein; Provisional; Region: PRK11114
498217009893	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
498217009894	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
498217009895	DXD motif; other site
498217009896	Cellulose synthase-like protein; Region: PLN02893
498217009897	PilZ domain; Region: PilZ; pfam07238
498217009898	YhjQ protein; Region: YhjQ; pfam06564
498217009899	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
498217009900	cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045
498217009901	Protein of unknown function (DUF2819); Region: DUF2819; pfam10995
498217009902	Protein of unknown function (DUF2636); Region: DUF2636; cl11897
498217009903	Protein of unknown function (DUF3260); Region: DUF3260; pfam11658
498217009904	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
498217009905	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
498217009906	Walker A/P-loop; other site
498217009907	ATP binding site [chemical binding]; other site
498217009908	Q-loop/lid; other site
498217009909	ABC transporter signature motif; other site
498217009910	Walker B; other site
498217009911	D-loop; other site
498217009912	H-loop/switch region; other site
498217009913	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
498217009914	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
498217009915	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
498217009916	Walker A/P-loop; other site
498217009917	ATP binding site [chemical binding]; other site
498217009918	Q-loop/lid; other site
498217009919	ABC transporter signature motif; other site
498217009920	Walker B; other site
498217009921	D-loop; other site
498217009922	H-loop/switch region; other site
498217009923	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
498217009924	dipeptide transporter; Provisional; Region: PRK10913
498217009925	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217009926	putative PBP binding loops; other site
498217009927	dimer interface [polypeptide binding]; other site
498217009928	ABC-ATPase subunit interface; other site
498217009929	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
498217009930	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217009931	dimer interface [polypeptide binding]; other site
498217009932	conserved gate region; other site
498217009933	putative PBP binding loops; other site
498217009934	ABC-ATPase subunit interface; other site
498217009935	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
498217009936	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
498217009937	peptide binding site [polypeptide binding]; other site
498217009938	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
498217009939	putative deacylase active site [active]
498217009940	regulatory protein UhpC; Provisional; Region: PRK11663
498217009941	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217009942	putative substrate translocation pore; other site
498217009943	sensory histidine kinase UhpB; Provisional; Region: PRK11644
498217009944	MASE1; Region: MASE1; cl17823
498217009945	MASE1; Region: MASE1; pfam05231
498217009946	Histidine kinase; Region: HisKA_3; pfam07730
498217009947	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217009948	ATP binding site [chemical binding]; other site
498217009949	Mg2+ binding site [ion binding]; other site
498217009950	G-X-G motif; other site
498217009951	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
498217009952	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217009953	active site
498217009954	phosphorylation site [posttranslational modification]
498217009955	intermolecular recognition site; other site
498217009956	dimerization interface [polypeptide binding]; other site
498217009957	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
498217009958	DNA binding residues [nucleotide binding]
498217009959	dimerization interface [polypeptide binding]; other site
498217009960	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
498217009961	ligand binding site [chemical binding]; other site
498217009962	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
498217009963	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
498217009964	dimerization interface [polypeptide binding]; other site
498217009965	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
498217009966	dimer interface [polypeptide binding]; other site
498217009967	putative CheW interface [polypeptide binding]; other site
498217009968	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
498217009969	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
498217009970	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
498217009971	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
498217009972	active site
498217009973	metal binding site [ion binding]; metal-binding site
498217009974	nudix motif; other site
498217009975	DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978
498217009976	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
498217009977	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
498217009978	Ligand Binding Site [chemical binding]; other site
498217009979	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
498217009980	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
498217009981	Integrase core domain; Region: rve_3; pfam13683
498217009982	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
498217009983	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
498217009984	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
498217009985	D5 N terminal like; Region: D5_N; smart00885
498217009986	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
498217009987	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
498217009988	Ash protein family; Region: Phage_ASH; pfam10554
498217009989	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
498217009990	transposase/IS protein; Provisional; Region: PRK09183
498217009991	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217009992	Walker A motif; other site
498217009993	ATP binding site [chemical binding]; other site
498217009994	Walker B motif; other site
498217009995	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
498217009996	Helix-turn-helix domain; Region: HTH_38; pfam13936
498217009997	Integrase core domain; Region: rve; pfam00665
498217009998	Phage polarity suppression protein (Psu); Region: Psu; pfam07455
498217009999	DNA-binding transcriptional regulator; Provisional; Region: PRK09678
498217010000	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
498217010001	Phage polarity suppression protein (Psu); Region: Psu; pfam07455
498217010002	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
498217010003	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
498217010004	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
498217010005	P-loop; other site
498217010006	Magnesium ion binding site [ion binding]; other site
498217010007	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
498217010008	P-loop; other site
498217010009	Magnesium ion binding site [ion binding]; other site
498217010010	integrase; Provisional; Region: PRK09692
498217010011	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
498217010012	active site
498217010013	Int/Topo IB signature motif; other site
498217010014	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
498217010015	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
498217010016	putative catalytic residues [active]
498217010017	putative nucleotide binding site [chemical binding]; other site
498217010018	putative aspartate binding site [chemical binding]; other site
498217010019	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
498217010020	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
498217010021	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
498217010022	cystathionine gamma-synthase; Provisional; Region: PRK08045
498217010023	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
498217010024	homodimer interface [polypeptide binding]; other site
498217010025	substrate-cofactor binding pocket; other site
498217010026	pyridoxal 5'-phosphate binding site [chemical binding]; other site
498217010027	catalytic residue [active]
498217010028	transcriptional repressor protein MetJ; Provisional; Region: PRK05264
498217010029	dimerization interface [polypeptide binding]; other site
498217010030	DNA binding site [nucleotide binding]
498217010031	corepressor binding sites; other site
498217010032	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
498217010033	primosome assembly protein PriA; Validated; Region: PRK05580
498217010034	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
498217010035	ATP binding site [chemical binding]; other site
498217010036	putative Mg++ binding site [ion binding]; other site
498217010037	helicase superfamily c-terminal domain; Region: HELICc; smart00490
498217010038	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
498217010039	DNA binding site [nucleotide binding]
498217010040	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
498217010041	domain linker motif; other site
498217010042	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
498217010043	dimerization interface [polypeptide binding]; other site
498217010044	ligand binding site [chemical binding]; other site
498217010045	essential cell division protein FtsN; Provisional; Region: PRK10927
498217010046	cell division protein FtsN; Provisional; Region: PRK12757
498217010047	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
498217010048	active site
498217010049	HslU subunit interaction site [polypeptide binding]; other site
498217010050	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
498217010051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217010052	Walker A motif; other site
498217010053	ATP binding site [chemical binding]; other site
498217010054	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217010055	Walker B motif; other site
498217010056	arginine finger; other site
498217010057	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
498217010058	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
498217010059	UbiA prenyltransferase family; Region: UbiA; pfam01040
498217010060	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
498217010061	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074
498217010062	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
498217010063	amphipathic channel; other site
498217010064	Asn-Pro-Ala signature motifs; other site
498217010065	glycerol kinase; Provisional; Region: glpK; PRK00047
498217010066	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
498217010067	N- and C-terminal domain interface [polypeptide binding]; other site
498217010068	active site
498217010069	MgATP binding site [chemical binding]; other site
498217010070	catalytic site [active]
498217010071	metal binding site [ion binding]; metal-binding site
498217010072	glycerol binding site [chemical binding]; other site
498217010073	homotetramer interface [polypeptide binding]; other site
498217010074	homodimer interface [polypeptide binding]; other site
498217010075	FBP binding site [chemical binding]; other site
498217010076	protein IIAGlc interface [polypeptide binding]; other site
498217010077	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
498217010078	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
498217010079	putative active site [active]
498217010080	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
498217010081	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217010082	putative substrate translocation pore; other site
498217010083	Predicted transcriptional regulator [Transcription]; Region: COG2345
498217010084	ferredoxin-NADP reductase; Provisional; Region: PRK10926
498217010085	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
498217010086	FAD binding pocket [chemical binding]; other site
498217010087	FAD binding motif [chemical binding]; other site
498217010088	phosphate binding motif [ion binding]; other site
498217010089	beta-alpha-beta structure motif; other site
498217010090	NAD binding pocket [chemical binding]; other site
498217010091	Predicted membrane protein [Function unknown]; Region: COG3152
498217010092	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
498217010093	triosephosphate isomerase; Provisional; Region: PRK14567
498217010094	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
498217010095	substrate binding site [chemical binding]; other site
498217010096	dimer interface [polypeptide binding]; other site
498217010097	catalytic triad [active]
498217010098	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
498217010099	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
498217010100	active site
498217010101	ADP/pyrophosphate binding site [chemical binding]; other site
498217010102	dimerization interface [polypeptide binding]; other site
498217010103	allosteric effector site; other site
498217010104	fructose-1,6-bisphosphate binding site; other site
498217010105	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
498217010106	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
498217010107	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
498217010108	dimer interface [polypeptide binding]; other site
498217010109	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
498217010110	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217010111	active site
498217010112	phosphorylation site [posttranslational modification]
498217010113	intermolecular recognition site; other site
498217010114	dimerization interface [polypeptide binding]; other site
498217010115	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
498217010116	DNA binding site [nucleotide binding]
498217010117	two-component sensor protein; Provisional; Region: cpxA; PRK09470
498217010118	HAMP domain; Region: HAMP; pfam00672
498217010119	dimerization interface [polypeptide binding]; other site
498217010120	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217010121	dimer interface [polypeptide binding]; other site
498217010122	phosphorylation site [posttranslational modification]
498217010123	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217010124	ATP binding site [chemical binding]; other site
498217010125	Mg2+ binding site [ion binding]; other site
498217010126	G-X-G motif; other site
498217010127	putative rRNA methylase; Provisional; Region: PRK10358
498217010128	serine acetyltransferase; Provisional; Region: cysE; PRK11132
498217010129	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
498217010130	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
498217010131	trimer interface [polypeptide binding]; other site
498217010132	active site
498217010133	substrate binding site [chemical binding]; other site
498217010134	CoA binding site [chemical binding]; other site
498217010135	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
498217010136	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
498217010137	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
498217010138	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
498217010139	SecA binding site; other site
498217010140	Preprotein binding site; other site
498217010141	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
498217010142	GSH binding site [chemical binding]; other site
498217010143	catalytic residues [active]
498217010144	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
498217010145	active site residue [active]
498217010146	phosphoglyceromutase; Provisional; Region: PRK05434
498217010147	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
498217010148	AmiB activator; Provisional; Region: PRK11637
498217010149	Peptidase family M23; Region: Peptidase_M23; pfam01551
498217010150	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
498217010151	NodB motif; other site
498217010152	putative active site [active]
498217010153	putative catalytic site [active]
498217010154	Zn binding site [ion binding]; other site
498217010155	hypothetical protein; Provisional; Region: PRK11027
498217010156	transcriptional regulator HdfR; Provisional; Region: PRK03601
498217010157	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217010158	LysR substrate binding domain; Region: LysR_substrate; pfam03466
498217010159	dimerization interface [polypeptide binding]; other site
498217010160	glutamate racemase; Provisional; Region: PRK00865
498217010161	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
498217010162	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
498217010163	N-terminal plug; other site
498217010164	ligand-binding site [chemical binding]; other site
498217010165	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217010166	active site
498217010167	motif I; other site
498217010168	motif II; other site
498217010169	acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009
498217010170	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
498217010171	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
498217010172	eyelet of channel; other site
498217010173	trimer interface [polypeptide binding]; other site
498217010174	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
498217010175	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217010176	S-adenosylmethionine binding site [chemical binding]; other site
498217010177	Protein of unknown function (DUF1422); Region: DUF1422; cl11649
498217010178	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
498217010179	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498217010180	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
498217010181	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498217010182	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
498217010183	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
498217010184	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
498217010185	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
498217010186	dimerization interface [polypeptide binding]; other site
498217010187	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
498217010188	catalytic triad [active]
498217010189	dimer interface [polypeptide binding]; other site
498217010190	Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029
498217010191	GSH binding site [chemical binding]; other site
498217010192	catalytic residues [active]
498217010193	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
498217010194	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
498217010195	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
498217010196	argininosuccinate lyase; Provisional; Region: PRK04833
498217010197	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
498217010198	active sites [active]
498217010199	tetramer interface [polypeptide binding]; other site
498217010200	argininosuccinate synthase; Provisional; Region: PRK13820
498217010201	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
498217010202	ANP binding site [chemical binding]; other site
498217010203	Substrate Binding Site II [chemical binding]; other site
498217010204	Substrate Binding Site I [chemical binding]; other site
498217010205	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
498217010206	nucleotide binding site [chemical binding]; other site
498217010207	N-acetyl-L-glutamate binding site [chemical binding]; other site
498217010208	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
498217010209	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
498217010210	acetylornithine deacetylase; Provisional; Region: PRK05111
498217010211	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
498217010212	metal binding site [ion binding]; metal-binding site
498217010213	putative dimer interface [polypeptide binding]; other site
498217010214	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
498217010215	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
498217010216	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
498217010217	FAD binding site [chemical binding]; other site
498217010218	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
498217010219	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498217010220	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
498217010221	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
498217010222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217010223	putative substrate translocation pore; other site
498217010224	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
498217010225	putative active site [active]
498217010226	dimerization interface [polypeptide binding]; other site
498217010227	putative tRNAtyr binding site [nucleotide binding]; other site
498217010228	hypothetical protein; Reviewed; Region: PRK01637
498217010229	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
498217010230	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
498217010231	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
498217010232	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
498217010233	G1 box; other site
498217010234	putative GEF interaction site [polypeptide binding]; other site
498217010235	GTP/Mg2+ binding site [chemical binding]; other site
498217010236	Switch I region; other site
498217010237	G2 box; other site
498217010238	G3 box; other site
498217010239	Switch II region; other site
498217010240	G4 box; other site
498217010241	G5 box; other site
498217010242	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
498217010243	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
498217010244	glutamine synthetase; Provisional; Region: glnA; PRK09469
498217010245	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
498217010246	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
498217010247	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
498217010248	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
498217010249	dimer interface [polypeptide binding]; other site
498217010250	phosphorylation site [posttranslational modification]
498217010251	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
498217010252	ATP binding site [chemical binding]; other site
498217010253	Mg2+ binding site [ion binding]; other site
498217010254	G-X-G motif; other site
498217010255	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
498217010256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
498217010257	active site
498217010258	phosphorylation site [posttranslational modification]
498217010259	intermolecular recognition site; other site
498217010260	dimerization interface [polypeptide binding]; other site
498217010261	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217010262	Walker A motif; other site
498217010263	ATP binding site [chemical binding]; other site
498217010264	Walker B motif; other site
498217010265	arginine finger; other site
498217010266	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
498217010267	putative transporter; Validated; Region: PRK03818
498217010268	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
498217010269	TrkA-C domain; Region: TrkA_C; pfam02080
498217010270	TrkA-C domain; Region: TrkA_C; pfam02080
498217010271	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
498217010272	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
498217010273	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
498217010274	FeS/SAM binding site; other site
498217010275	HemN C-terminal domain; Region: HemN_C; pfam06969
498217010276	Der GTPase activator; Provisional; Region: PRK05244
498217010277	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
498217010278	G1 box; other site
498217010279	GTP/Mg2+ binding site [chemical binding]; other site
498217010280	Switch I region; other site
498217010281	G2 box; other site
498217010282	G3 box; other site
498217010283	Switch II region; other site
498217010284	G4 box; other site
498217010285	G5 box; other site
498217010286	DNA polymerase I; Provisional; Region: PRK05755
498217010287	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
498217010288	active site
498217010289	metal binding site 1 [ion binding]; metal-binding site
498217010290	putative 5' ssDNA interaction site; other site
498217010291	metal binding site 3; metal-binding site
498217010292	metal binding site 2 [ion binding]; metal-binding site
498217010293	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
498217010294	putative DNA binding site [nucleotide binding]; other site
498217010295	putative metal binding site [ion binding]; other site
498217010296	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
498217010297	active site
498217010298	catalytic site [active]
498217010299	substrate binding site [chemical binding]; other site
498217010300	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
498217010301	active site
498217010302	DNA binding site [nucleotide binding]
498217010303	catalytic site [active]
498217010304	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
498217010305	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
498217010306	putative acyl-acceptor binding pocket; other site
498217010307	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
498217010308	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
498217010309	catalytic residues [active]
498217010310	hinge region; other site
498217010311	alpha helical domain; other site
498217010312	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
498217010313	serine/threonine protein kinase; Provisional; Region: PRK11768
498217010314	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
498217010315	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
498217010316	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
498217010317	GTP binding site; other site
498217010318	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
498217010319	Walker A motif; other site
498217010320	Transcriptional regulators [Transcription]; Region: FadR; COG2186
498217010321	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
498217010322	DNA-binding site [nucleotide binding]; DNA binding site
498217010323	FCD domain; Region: FCD; pfam07729
498217010324	putative transporter; Provisional; Region: PRK10504
498217010325	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217010326	transcriptional repressor RbsR; Provisional; Region: PRK10423
498217010327	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
498217010328	DNA binding site [nucleotide binding]
498217010329	domain linker motif; other site
498217010330	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
498217010331	dimerization interface [polypeptide binding]; other site
498217010332	ligand binding site [chemical binding]; other site
498217010333	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
498217010334	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
498217010335	substrate binding site [chemical binding]; other site
498217010336	dimer interface [polypeptide binding]; other site
498217010337	ATP binding site [chemical binding]; other site
498217010338	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
498217010339	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
498217010340	ligand binding site [chemical binding]; other site
498217010341	dimerization interface [polypeptide binding]; other site
498217010342	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
498217010343	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
498217010344	TM-ABC transporter signature motif; other site
498217010345	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
498217010346	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
498217010347	Walker A/P-loop; other site
498217010348	ATP binding site [chemical binding]; other site
498217010349	Q-loop/lid; other site
498217010350	ABC transporter signature motif; other site
498217010351	Walker B; other site
498217010352	D-loop; other site
498217010353	H-loop/switch region; other site
498217010354	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
498217010355	D-ribose pyranase; Provisional; Region: PRK11797
498217010356	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
498217010357	potassium uptake protein; Region: kup; TIGR00794
498217010358	regulatory ATPase RavA; Provisional; Region: PRK13531
498217010359	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
498217010360	Walker A motif; other site
498217010361	ATP binding site [chemical binding]; other site
498217010362	Walker B motif; other site
498217010363	arginine finger; other site
498217010364	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
498217010365	hypothetical protein; Provisional; Region: yieM; PRK10997
498217010366	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
498217010367	metal ion-dependent adhesion site (MIDAS); other site
498217010368	asparagine synthetase AsnA; Provisional; Region: PRK05425
498217010369	motif 1; other site
498217010370	dimer interface [polypeptide binding]; other site
498217010371	active site
498217010372	motif 2; other site
498217010373	motif 3; other site
498217010374	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
498217010375	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
498217010376	putative DNA binding site [nucleotide binding]; other site
498217010377	putative Zn2+ binding site [ion binding]; other site
498217010378	AsnC family; Region: AsnC_trans_reg; pfam01037
498217010379	FMN-binding protein MioC; Provisional; Region: PRK09004
498217010380	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
498217010381	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
498217010382	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
498217010383	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
498217010384	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
498217010385	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
498217010386	S-adenosylmethionine binding site [chemical binding]; other site
498217010387	ATP synthase I chain; Region: ATP_synt_I; cl09170
498217010388	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
498217010389	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
498217010390	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
498217010391	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
498217010392	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
498217010393	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
498217010394	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
498217010395	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
498217010396	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
498217010397	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
498217010398	Walker A motif; other site
498217010399	ATP binding site [chemical binding]; other site
498217010400	Walker B motif; other site
498217010401	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
498217010402	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
498217010403	core domain interface [polypeptide binding]; other site
498217010404	delta subunit interface [polypeptide binding]; other site
498217010405	epsilon subunit interface [polypeptide binding]; other site
498217010406	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
498217010407	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
498217010408	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
498217010409	alpha subunit interaction interface [polypeptide binding]; other site
498217010410	Walker A motif; other site
498217010411	ATP binding site [chemical binding]; other site
498217010412	Walker B motif; other site
498217010413	inhibitor binding site; inhibition site
498217010414	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
498217010415	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
498217010416	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
498217010417	gamma subunit interface [polypeptide binding]; other site
498217010418	epsilon subunit interface [polypeptide binding]; other site
498217010419	LBP interface [polypeptide binding]; other site
498217010420	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
498217010421	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
498217010422	Substrate binding site; other site
498217010423	Mg++ binding site; other site
498217010424	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
498217010425	active site
498217010426	substrate binding site [chemical binding]; other site
498217010427	CoA binding site [chemical binding]; other site
498217010428	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
498217010429	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
498217010430	glutaminase active site [active]
498217010431	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
498217010432	dimer interface [polypeptide binding]; other site
498217010433	active site
498217010434	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
498217010435	dimer interface [polypeptide binding]; other site
498217010436	active site
498217010437	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
498217010438	active site
498217010439	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
498217010440	substrate binding pocket [chemical binding]; other site
498217010441	membrane-bound complex binding site; other site
498217010442	hinge residues; other site
498217010443	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
498217010444	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217010445	dimer interface [polypeptide binding]; other site
498217010446	conserved gate region; other site
498217010447	putative PBP binding loops; other site
498217010448	ABC-ATPase subunit interface; other site
498217010449	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
498217010450	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
498217010451	dimer interface [polypeptide binding]; other site
498217010452	conserved gate region; other site
498217010453	putative PBP binding loops; other site
498217010454	ABC-ATPase subunit interface; other site
498217010455	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
498217010456	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
498217010457	Walker A/P-loop; other site
498217010458	ATP binding site [chemical binding]; other site
498217010459	Q-loop/lid; other site
498217010460	ABC transporter signature motif; other site
498217010461	Walker B; other site
498217010462	D-loop; other site
498217010463	H-loop/switch region; other site
498217010464	transcriptional regulator PhoU; Provisional; Region: PRK11115
498217010465	PhoU domain; Region: PhoU; pfam01895
498217010466	PhoU domain; Region: PhoU; pfam01895
498217010467	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
498217010468	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
498217010469	motif II; other site
498217010470	cryptic adenine deaminase; Provisional; Region: PRK10027
498217010471	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
498217010472	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
498217010473	active site
498217010474	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
498217010475	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
498217010476	Predicted peptidase [General function prediction only]; Region: COG4099
498217010477	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
498217010478	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
498217010479	Uncharacterized conserved protein [Function unknown]; Region: COG0398
498217010480	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
498217010481	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
498217010482	Smr domain; Region: Smr; pfam01713
498217010483	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
498217010484	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
498217010485	trmE is a tRNA modification GTPase; Region: trmE; cd04164
498217010486	G1 box; other site
498217010487	GTP/Mg2+ binding site [chemical binding]; other site
498217010488	Switch I region; other site
498217010489	G2 box; other site
498217010490	Switch II region; other site
498217010491	G3 box; other site
498217010492	G4 box; other site
498217010493	G5 box; other site
498217010494	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
498217010495	membrane protein insertase; Provisional; Region: PRK01318
498217010496	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
498217010497	Ribonuclease P; Region: Ribonuclease_P; cl00457
498217010498	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
498217010499	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
498217010500	Walker A motif; other site
498217010501	ATP binding site [chemical binding]; other site
498217010502	Walker B motif; other site
498217010503	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
498217010504	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
498217010505	ATP binding site [chemical binding]; other site
498217010506	Walker A motif; other site
498217010507	hexamer interface [polypeptide binding]; other site
498217010508	Walker B motif; other site
498217010509	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
498217010510	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
498217010511	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
498217010512	VirB7 interaction site; other site
498217010513	Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736
498217010514	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
498217010515	Type IV secretion system proteins; Region: T4SS; pfam07996
498217010516	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
498217010517	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
498217010518	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
498217010519	TrbC/VIRB2 family; Region: TrbC; pfam04956
498217010520	DNA topoisomerase I; Validated; Region: PRK06599
498217010521	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
498217010522	active site
498217010523	interdomain interaction site; other site
498217010524	putative metal-binding site [ion binding]; other site
498217010525	nucleotide binding site [chemical binding]; other site
498217010526	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
498217010527	domain I; other site
498217010528	DNA binding groove [nucleotide binding]
498217010529	phosphate binding site [ion binding]; other site
498217010530	domain II; other site
498217010531	domain III; other site
498217010532	nucleotide binding site [chemical binding]; other site
498217010533	catalytic site [active]
498217010534	domain IV; other site
498217010535	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
498217010536	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
498217010537	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
498217010538	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
498217010539	active site
498217010540	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
498217010541	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
498217010542	catalytic residues [active]
498217010543	catalytic nucleophile [active]
498217010544	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
498217010545	conjugal transfer protein TrbP; Provisional; Region: PRK13882
498217010546	TraX protein; Region: TraX; cl05434
498217010547	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
498217010548	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498217010549	sequence-specific DNA binding site [nucleotide binding]; other site
498217010550	salt bridge; other site
498217010551	Antirestriction protein; Region: Antirestrict; pfam03230
498217010552	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
498217010553	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
498217010554	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
498217010555	P-loop; other site
498217010556	Magnesium ion binding site [ion binding]; other site
498217010557	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
498217010558	Magnesium ion binding site [ion binding]; other site
498217010559	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
498217010560	ParB-like nuclease domain; Region: ParB; smart00470
498217010561	KorB domain; Region: KorB; pfam08535
498217010562	KorB C-terminal beta-barrel domain; Region: KorB_C; pfam06613
498217010563	Restriction endonuclease; Region: Mrr_cat; pfam04471
498217010564	SprT-like family; Region: SprT-like; pfam10263
498217010565	SprT homologues; Region: SprT; cl01182
498217010566	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
498217010567	Major Facilitator Superfamily; Region: MFS_1; pfam07690
498217010568	putative substrate translocation pore; other site
498217010569	tetracycline repressor protein TetR; Provisional; Region: PRK13756
498217010570	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
498217010571	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
498217010572	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655
498217010573	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
498217010574	Phosphotransferase enzyme family; Region: APH; pfam01636
498217010575	active site
498217010576	ATP binding site [chemical binding]; other site
498217010577	antibiotic binding site [chemical binding]; other site
498217010578	dihydropteroate synthase; Region: DHPS; TIGR01496
498217010579	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
498217010580	substrate binding pocket [chemical binding]; other site
498217010581	dimer interface [polypeptide binding]; other site
498217010582	inhibitor binding site; inhibition site
498217010583	SnoaL-like domain; Region: SnoaL_2; pfam12680
498217010584	Chloramphenicol acetyltransferase; Region: CAT; pfam00302
498217010585	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
498217010586	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
498217010587	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
498217010588	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
498217010589	type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863
498217010590	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
498217010591	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
498217010592	non-specific DNA binding site [nucleotide binding]; other site
498217010593	salt bridge; other site
498217010594	sequence-specific DNA binding site [nucleotide binding]; other site
498217010595	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
498217010596	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
498217010597	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
498217010598	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
498217010599	active site
498217010600	metal binding site [ion binding]; metal-binding site
498217010601	interdomain interaction site; other site