-- dump date 20140619_070150 -- class Genbank::misc_feature -- table misc_feature_note -- id note 718251000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 718251000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 718251000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251000004 Walker A motif; other site 718251000005 ATP binding site [chemical binding]; other site 718251000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 718251000007 Walker B motif; other site 718251000008 arginine finger; other site 718251000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 718251000010 DnaA box-binding interface [nucleotide binding]; other site 718251000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 718251000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 718251000013 putative DNA binding surface [nucleotide binding]; other site 718251000014 dimer interface [polypeptide binding]; other site 718251000015 beta-clamp/clamp loader binding surface; other site 718251000016 beta-clamp/translesion DNA polymerase binding surface; other site 718251000017 recombination protein F; Reviewed; Region: recF; PRK00064 718251000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251000019 Walker A/P-loop; other site 718251000020 ATP binding site [chemical binding]; other site 718251000021 Q-loop/lid; other site 718251000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251000023 ABC transporter signature motif; other site 718251000024 Walker B; other site 718251000025 D-loop; other site 718251000026 H-loop/switch region; other site 718251000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 718251000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251000029 ATP binding site [chemical binding]; other site 718251000030 Mg2+ binding site [ion binding]; other site 718251000031 G-X-G motif; other site 718251000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 718251000033 anchoring element; other site 718251000034 dimer interface [polypeptide binding]; other site 718251000035 ATP binding site [chemical binding]; other site 718251000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 718251000037 active site 718251000038 putative metal-binding site [ion binding]; other site 718251000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 718251000040 sugar phosphate phosphatase; Provisional; Region: PRK10513 718251000041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251000042 active site 718251000043 motif I; other site 718251000044 motif II; other site 718251000045 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251000046 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 718251000047 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 718251000048 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 718251000049 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 718251000050 putative dimer interface [polypeptide binding]; other site 718251000051 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 718251000052 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 718251000053 putative dimer interface [polypeptide binding]; other site 718251000054 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 718251000055 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718251000056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251000057 homodimer interface [polypeptide binding]; other site 718251000058 catalytic residue [active] 718251000059 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 718251000060 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 718251000061 DALR anticodon binding domain; Region: DALR_1; pfam05746 718251000062 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 718251000063 dimer interface [polypeptide binding]; other site 718251000064 motif 1; other site 718251000065 active site 718251000066 motif 2; other site 718251000067 motif 3; other site 718251000068 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 718251000069 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 718251000070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718251000071 Coenzyme A binding pocket [chemical binding]; other site 718251000072 Predicted membrane protein [Function unknown]; Region: COG2119 718251000073 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 718251000074 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 718251000075 putative outer membrane lipoprotein; Provisional; Region: PRK10510 718251000076 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 718251000077 ligand binding site [chemical binding]; other site 718251000078 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 718251000079 CPxP motif; other site 718251000080 hypothetical protein; Provisional; Region: PRK11212 718251000081 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 718251000082 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 718251000083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718251000084 Coenzyme A binding pocket [chemical binding]; other site 718251000085 hypothetical protein; Provisional; Region: PRK11615 718251000086 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 718251000087 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 718251000088 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 718251000089 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 718251000090 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 718251000091 generic binding surface II; other site 718251000092 ssDNA binding site; other site 718251000093 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718251000094 ATP binding site [chemical binding]; other site 718251000095 putative Mg++ binding site [ion binding]; other site 718251000096 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718251000097 nucleotide binding region [chemical binding]; other site 718251000098 ATP-binding site [chemical binding]; other site 718251000099 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 718251000100 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 718251000101 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 718251000102 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 718251000103 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 718251000104 Zn2+ binding site [ion binding]; other site 718251000105 Mg2+ binding site [ion binding]; other site 718251000106 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 718251000107 synthetase active site [active] 718251000108 NTP binding site [chemical binding]; other site 718251000109 metal binding site [ion binding]; metal-binding site 718251000110 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 718251000111 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 718251000112 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 718251000113 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 718251000114 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 718251000115 catalytic site [active] 718251000116 G-X2-G-X-G-K; other site 718251000117 Predicted membrane protein [Function unknown]; Region: COG2860 718251000118 UPF0126 domain; Region: UPF0126; pfam03458 718251000119 UPF0126 domain; Region: UPF0126; pfam03458 718251000120 hypothetical protein; Provisional; Region: PRK11820 718251000121 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 718251000122 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 718251000123 ribonuclease PH; Reviewed; Region: rph; PRK00173 718251000124 Ribonuclease PH; Region: RNase_PH_bact; cd11362 718251000125 hexamer interface [polypeptide binding]; other site 718251000126 active site 718251000127 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718251000128 active site 718251000129 division inhibitor protein; Provisional; Region: slmA; PRK09480 718251000130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718251000131 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 718251000132 trimer interface [polypeptide binding]; other site 718251000133 active site 718251000134 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 718251000135 Flavoprotein; Region: Flavoprotein; pfam02441 718251000136 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 718251000137 hypothetical protein; Reviewed; Region: PRK00024 718251000138 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 718251000139 MPN+ (JAMM) motif; other site 718251000140 Zinc-binding site [ion binding]; other site 718251000141 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 718251000142 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 718251000143 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 718251000144 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 718251000145 DNA binding site [nucleotide binding] 718251000146 catalytic residue [active] 718251000147 H2TH interface [polypeptide binding]; other site 718251000148 putative catalytic residues [active] 718251000149 turnover-facilitating residue; other site 718251000150 intercalation triad [nucleotide binding]; other site 718251000151 8OG recognition residue [nucleotide binding]; other site 718251000152 putative reading head residues; other site 718251000153 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 718251000154 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 718251000155 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 718251000156 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 718251000157 active site 718251000158 (T/H)XGH motif; other site 718251000159 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 718251000160 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 718251000161 putative metal binding site; other site 718251000162 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 718251000163 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 718251000164 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 718251000165 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 718251000166 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718251000167 putative ADP-binding pocket [chemical binding]; other site 718251000168 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 718251000169 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 718251000170 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 718251000171 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 718251000172 putative active site [active] 718251000173 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 718251000174 putative active site [active] 718251000175 putative catalytic site [active] 718251000176 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 718251000177 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718251000178 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718251000179 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 718251000180 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718251000181 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 718251000182 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 718251000183 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 718251000184 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 718251000185 putative active site [active] 718251000186 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 718251000187 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 718251000188 putative active site [active] 718251000189 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 718251000190 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 718251000191 NADP binding site [chemical binding]; other site 718251000192 homopentamer interface [polypeptide binding]; other site 718251000193 substrate binding site [chemical binding]; other site 718251000194 active site 718251000195 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 718251000196 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 718251000197 substrate-cofactor binding pocket; other site 718251000198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251000199 catalytic residue [active] 718251000200 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 718251000201 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 718251000202 NAD(P) binding site [chemical binding]; other site 718251000203 putative ATP-dependent protease; Provisional; Region: PRK09862 718251000204 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 718251000205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251000206 Walker A motif; other site 718251000207 ATP binding site [chemical binding]; other site 718251000208 Walker B motif; other site 718251000209 arginine finger; other site 718251000210 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 718251000211 putative sialic acid transporter; Region: 2A0112; TIGR00891 718251000212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251000213 putative substrate translocation pore; other site 718251000214 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 718251000215 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 718251000216 dimer interface [polypeptide binding]; other site 718251000217 PYR/PP interface [polypeptide binding]; other site 718251000218 TPP binding site [chemical binding]; other site 718251000219 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 718251000220 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 718251000221 TPP-binding site [chemical binding]; other site 718251000222 dimer interface [polypeptide binding]; other site 718251000223 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 718251000224 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 718251000225 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 718251000226 homodimer interface [polypeptide binding]; other site 718251000227 substrate-cofactor binding pocket; other site 718251000228 catalytic residue [active] 718251000229 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 718251000230 threonine dehydratase; Reviewed; Region: PRK09224 718251000231 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 718251000232 tetramer interface [polypeptide binding]; other site 718251000233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251000234 catalytic residue [active] 718251000235 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 718251000236 putative Ile/Val binding site [chemical binding]; other site 718251000237 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 718251000238 putative Ile/Val binding site [chemical binding]; other site 718251000239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251000240 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 718251000241 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718251000242 dimerization interface [polypeptide binding]; other site 718251000243 ketol-acid reductoisomerase; Validated; Region: PRK05225 718251000244 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 718251000245 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 718251000246 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 718251000247 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 718251000248 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 718251000249 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 718251000250 Part of AAA domain; Region: AAA_19; pfam13245 718251000251 Family description; Region: UvrD_C_2; pfam13538 718251000252 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 718251000253 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 718251000254 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 718251000255 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 718251000256 ATP binding site [chemical binding]; other site 718251000257 Mg++ binding site [ion binding]; other site 718251000258 motif III; other site 718251000259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718251000260 nucleotide binding region [chemical binding]; other site 718251000261 ATP-binding site [chemical binding]; other site 718251000262 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 718251000263 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 718251000264 catalytic residues [active] 718251000265 transcription termination factor Rho; Provisional; Region: rho; PRK09376 718251000266 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 718251000267 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 718251000268 RNA binding site [nucleotide binding]; other site 718251000269 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 718251000270 multimer interface [polypeptide binding]; other site 718251000271 Walker A motif; other site 718251000272 ATP binding site [chemical binding]; other site 718251000273 Walker B motif; other site 718251000274 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 718251000275 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 718251000276 Mg++ binding site [ion binding]; other site 718251000277 putative catalytic motif [active] 718251000278 substrate binding site [chemical binding]; other site 718251000279 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 718251000280 Chain length determinant protein; Region: Wzz; cl15801 718251000281 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 718251000282 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 718251000283 active site 718251000284 homodimer interface [polypeptide binding]; other site 718251000285 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 718251000286 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 718251000287 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 718251000288 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 718251000289 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 718251000290 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 718251000291 NAD binding site [chemical binding]; other site 718251000292 substrate binding site [chemical binding]; other site 718251000293 homodimer interface [polypeptide binding]; other site 718251000294 active site 718251000295 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 718251000296 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 718251000297 substrate binding site; other site 718251000298 tetramer interface; other site 718251000299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718251000300 Coenzyme A binding pocket [chemical binding]; other site 718251000301 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 718251000302 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 718251000303 inhibitor-cofactor binding pocket; inhibition site 718251000304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251000305 catalytic residue [active] 718251000306 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 718251000307 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 718251000308 putative common antigen polymerase; Provisional; Region: PRK02975 718251000309 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 718251000310 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 718251000311 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 718251000312 HemY protein N-terminus; Region: HemY_N; pfam07219 718251000313 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 718251000314 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 718251000315 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 718251000316 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 718251000317 active site 718251000318 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 718251000319 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 718251000320 domain interfaces; other site 718251000321 active site 718251000322 adenylate cyclase; Provisional; Region: cyaA; PRK09450 718251000323 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 718251000324 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 718251000325 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 718251000326 putative iron binding site [ion binding]; other site 718251000327 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 718251000328 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 718251000329 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 718251000330 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 718251000331 hypothetical protein; Provisional; Region: PRK10963 718251000332 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 718251000333 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 718251000334 active site 718251000335 DNA binding site [nucleotide binding] 718251000336 Int/Topo IB signature motif; other site 718251000337 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 718251000338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251000339 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 718251000340 Part of AAA domain; Region: AAA_19; pfam13245 718251000341 Family description; Region: UvrD_C_2; pfam13538 718251000342 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 718251000343 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 718251000344 Cl binding site [ion binding]; other site 718251000345 oligomer interface [polypeptide binding]; other site 718251000346 Putative ammonia monooxygenase; Region: AmoA; pfam05145 718251000347 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 718251000348 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 718251000349 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 718251000350 EamA-like transporter family; Region: EamA; cl17759 718251000351 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 718251000352 dimerization interface [polypeptide binding]; other site 718251000353 substrate binding site [chemical binding]; other site 718251000354 active site 718251000355 calcium binding site [ion binding]; other site 718251000356 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 718251000357 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718251000358 ATP binding site [chemical binding]; other site 718251000359 putative Mg++ binding site [ion binding]; other site 718251000360 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718251000361 nucleotide binding region [chemical binding]; other site 718251000362 ATP-binding site [chemical binding]; other site 718251000363 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 718251000364 HRDC domain; Region: HRDC; pfam00570 718251000365 Uncharacterized conserved protein [Function unknown]; Region: COG1912 718251000366 threonine efflux system; Provisional; Region: PRK10229 718251000367 low affinity gluconate transporter; Provisional; Region: PRK10472 718251000368 GntP family permease; Region: GntP_permease; pfam02447 718251000369 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 718251000370 ATP-binding site [chemical binding]; other site 718251000371 Gluconate-6-phosphate binding site [chemical binding]; other site 718251000372 Shikimate kinase; Region: SKI; pfam01202 718251000373 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 718251000374 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718251000375 DNA binding site [nucleotide binding] 718251000376 domain linker motif; other site 718251000377 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 718251000378 putative ligand binding site [chemical binding]; other site 718251000379 putative dimerization interface [polypeptide binding]; other site 718251000380 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 718251000381 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 718251000382 metal-binding site [ion binding] 718251000383 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 718251000384 Soluble P-type ATPase [General function prediction only]; Region: COG4087 718251000385 Surface antigen; Region: Bac_surface_Ag; pfam01103 718251000386 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 718251000387 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 718251000388 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 718251000389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251000390 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 718251000391 putative dimerization interface [polypeptide binding]; other site 718251000392 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 718251000393 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 718251000394 THF binding site; other site 718251000395 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 718251000396 substrate binding site [chemical binding]; other site 718251000397 THF binding site; other site 718251000398 zinc-binding site [ion binding]; other site 718251000399 uridine phosphorylase; Provisional; Region: PRK11178 718251000400 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 718251000401 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 718251000402 Carbon starvation protein CstA; Region: CstA; pfam02554 718251000403 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 718251000404 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 718251000405 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 718251000406 DNA recombination protein RmuC; Provisional; Region: PRK10361 718251000407 RmuC family; Region: RmuC; pfam02646 718251000408 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 718251000409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251000410 S-adenosylmethionine binding site [chemical binding]; other site 718251000411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 718251000412 SCP-2 sterol transfer family; Region: SCP2; pfam02036 718251000413 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 718251000414 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 718251000415 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 718251000416 sec-independent translocase; Provisional; Region: PRK01770 718251000417 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 718251000418 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 718251000419 active site 718251000420 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 718251000421 dimer interface [polypeptide binding]; other site 718251000422 active site 718251000423 aspartate-rich active site metal binding site; other site 718251000424 allosteric magnesium binding site [ion binding]; other site 718251000425 Schiff base residues; other site 718251000426 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 718251000427 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 718251000428 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 718251000429 heterodimer interface [polypeptide binding]; other site 718251000430 homodimer interface [polypeptide binding]; other site 718251000431 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 718251000432 active site pocket [active] 718251000433 oxyanion hole [active] 718251000434 catalytic triad [active] 718251000435 active site nucleophile [active] 718251000436 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 718251000437 FMN reductase; Validated; Region: fre; PRK08051 718251000438 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 718251000439 FAD binding pocket [chemical binding]; other site 718251000440 FAD binding motif [chemical binding]; other site 718251000441 phosphate binding motif [ion binding]; other site 718251000442 beta-alpha-beta structure motif; other site 718251000443 NAD binding pocket [chemical binding]; other site 718251000444 proline dipeptidase; Provisional; Region: PRK13607 718251000445 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 718251000446 active site 718251000447 hypothetical protein; Provisional; Region: PRK11568 718251000448 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 718251000449 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 718251000450 potassium transporter; Provisional; Region: PRK10750 718251000451 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 718251000452 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 718251000453 putative transposase OrfB; Reviewed; Region: PHA02517 718251000454 HTH-like domain; Region: HTH_21; pfam13276 718251000455 Integrase core domain; Region: rve; pfam00665 718251000456 Integrase core domain; Region: rve_3; pfam13683 718251000457 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 718251000458 FAD binding domain; Region: FAD_binding_4; pfam01565 718251000459 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 718251000460 Biotin operon repressor [Transcription]; Region: BirA; COG1654 718251000461 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 718251000462 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 718251000463 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 718251000464 pantothenate kinase; Provisional; Region: PRK05439 718251000465 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 718251000466 ATP-binding site [chemical binding]; other site 718251000467 CoA-binding site [chemical binding]; other site 718251000468 Mg2+-binding site [ion binding]; other site 718251000469 elongation factor Tu; Reviewed; Region: PRK00049 718251000470 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 718251000471 G1 box; other site 718251000472 GEF interaction site [polypeptide binding]; other site 718251000473 GTP/Mg2+ binding site [chemical binding]; other site 718251000474 Switch I region; other site 718251000475 G2 box; other site 718251000476 G3 box; other site 718251000477 Switch II region; other site 718251000478 G4 box; other site 718251000479 G5 box; other site 718251000480 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 718251000481 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 718251000482 Antibiotic Binding Site [chemical binding]; other site 718251000483 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 718251000484 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 718251000485 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 718251000486 putative homodimer interface [polypeptide binding]; other site 718251000487 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 718251000488 heterodimer interface [polypeptide binding]; other site 718251000489 homodimer interface [polypeptide binding]; other site 718251000490 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 718251000491 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 718251000492 23S rRNA interface [nucleotide binding]; other site 718251000493 L7/L12 interface [polypeptide binding]; other site 718251000494 putative thiostrepton binding site; other site 718251000495 L25 interface [polypeptide binding]; other site 718251000496 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 718251000497 mRNA/rRNA interface [nucleotide binding]; other site 718251000498 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 718251000499 23S rRNA interface [nucleotide binding]; other site 718251000500 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 718251000501 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 718251000502 core dimer interface [polypeptide binding]; other site 718251000503 peripheral dimer interface [polypeptide binding]; other site 718251000504 L10 interface [polypeptide binding]; other site 718251000505 L11 interface [polypeptide binding]; other site 718251000506 putative EF-Tu interaction site [polypeptide binding]; other site 718251000507 putative EF-G interaction site [polypeptide binding]; other site 718251000508 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 718251000509 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 718251000510 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 718251000511 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 718251000512 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 718251000513 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 718251000514 RPB3 interaction site [polypeptide binding]; other site 718251000515 RPB1 interaction site [polypeptide binding]; other site 718251000516 RPB11 interaction site [polypeptide binding]; other site 718251000517 RPB10 interaction site [polypeptide binding]; other site 718251000518 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 718251000519 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 718251000520 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 718251000521 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 718251000522 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 718251000523 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 718251000524 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 718251000525 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 718251000526 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 718251000527 DNA binding site [nucleotide binding] 718251000528 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 718251000529 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 718251000530 thiamine phosphate binding site [chemical binding]; other site 718251000531 active site 718251000532 pyrophosphate binding site [ion binding]; other site 718251000533 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 718251000534 ThiC-associated domain; Region: ThiC-associated; pfam13667 718251000535 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 718251000536 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 718251000537 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 718251000538 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 718251000539 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 718251000540 putative NADH binding site [chemical binding]; other site 718251000541 putative active site [active] 718251000542 nudix motif; other site 718251000543 putative metal binding site [ion binding]; other site 718251000544 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 718251000545 substrate binding site [chemical binding]; other site 718251000546 active site 718251000547 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 718251000548 Active_site [active] 718251000549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 718251000550 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 718251000551 IHF dimer interface [polypeptide binding]; other site 718251000552 IHF - DNA interface [nucleotide binding]; other site 718251000553 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 718251000554 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 718251000555 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 718251000556 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 718251000557 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 718251000558 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 718251000559 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 718251000560 purine monophosphate binding site [chemical binding]; other site 718251000561 dimer interface [polypeptide binding]; other site 718251000562 putative catalytic residues [active] 718251000563 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 718251000564 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 718251000565 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 718251000566 acetyl-CoA synthetase; Provisional; Region: PRK00174 718251000567 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 718251000568 active site 718251000569 CoA binding site [chemical binding]; other site 718251000570 acyl-activating enzyme (AAE) consensus motif; other site 718251000571 AMP binding site [chemical binding]; other site 718251000572 acetate binding site [chemical binding]; other site 718251000573 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 718251000574 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 718251000575 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 718251000576 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 718251000577 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 718251000578 dimer interface [polypeptide binding]; other site 718251000579 ADP-ribose binding site [chemical binding]; other site 718251000580 active site 718251000581 nudix motif; other site 718251000582 metal binding site [ion binding]; metal-binding site 718251000583 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 718251000584 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 718251000585 active site 718251000586 metal binding site [ion binding]; metal-binding site 718251000587 hexamer interface [polypeptide binding]; other site 718251000588 esterase YqiA; Provisional; Region: PRK11071 718251000589 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 718251000590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251000591 ATP binding site [chemical binding]; other site 718251000592 Mg2+ binding site [ion binding]; other site 718251000593 G-X-G motif; other site 718251000594 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 718251000595 anchoring element; other site 718251000596 dimer interface [polypeptide binding]; other site 718251000597 ATP binding site [chemical binding]; other site 718251000598 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 718251000599 active site 718251000600 metal binding site [ion binding]; metal-binding site 718251000601 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 718251000602 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 718251000603 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 718251000604 CAP-like domain; other site 718251000605 active site 718251000606 primary dimer interface [polypeptide binding]; other site 718251000607 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 718251000608 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 718251000609 putative acyl-acceptor binding pocket; other site 718251000610 FtsI repressor; Provisional; Region: PRK10883 718251000611 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 718251000612 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 718251000613 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 718251000614 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 718251000615 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 718251000616 substrate binding pocket [chemical binding]; other site 718251000617 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 718251000618 B12 binding site [chemical binding]; other site 718251000619 cobalt ligand [ion binding]; other site 718251000620 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 718251000621 aspartate kinase III; Validated; Region: PRK09084 718251000622 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 718251000623 nucleotide binding site [chemical binding]; other site 718251000624 substrate binding site [chemical binding]; other site 718251000625 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 718251000626 lysine allosteric regulatory site; other site 718251000627 dimer interface [polypeptide binding]; other site 718251000628 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 718251000629 dimer interface [polypeptide binding]; other site 718251000630 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 718251000631 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 718251000632 active site 718251000633 dimer interface [polypeptide binding]; other site 718251000634 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 718251000635 dimer interface [polypeptide binding]; other site 718251000636 active site 718251000637 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 718251000638 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 718251000639 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 718251000640 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 718251000641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251000642 dimer interface [polypeptide binding]; other site 718251000643 conserved gate region; other site 718251000644 putative PBP binding loops; other site 718251000645 ABC-ATPase subunit interface; other site 718251000646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251000647 dimer interface [polypeptide binding]; other site 718251000648 conserved gate region; other site 718251000649 putative PBP binding loops; other site 718251000650 ABC-ATPase subunit interface; other site 718251000651 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 718251000652 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 718251000653 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 718251000654 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 718251000655 Walker A/P-loop; other site 718251000656 ATP binding site [chemical binding]; other site 718251000657 Q-loop/lid; other site 718251000658 ABC transporter signature motif; other site 718251000659 Walker B; other site 718251000660 D-loop; other site 718251000661 H-loop/switch region; other site 718251000662 TOBE domain; Region: TOBE_2; pfam08402 718251000663 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 718251000664 trimer interface; other site 718251000665 sugar binding site [chemical binding]; other site 718251000666 maltose regulon periplasmic protein; Provisional; Region: PRK10564 718251000667 Chorismate lyase; Region: Chor_lyase; cl01230 718251000668 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 718251000669 UbiA prenyltransferase family; Region: UbiA; pfam01040 718251000670 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718251000671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251000672 putative substrate translocation pore; other site 718251000673 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 718251000674 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 718251000675 putative acyl-acceptor binding pocket; other site 718251000676 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 718251000677 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 718251000678 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 718251000679 transmembrane helices; other site 718251000680 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 718251000681 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 718251000682 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 718251000683 Coenzyme A transferase; Region: CoA_trans; cl17247 718251000684 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 718251000685 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 718251000686 citrate lyase subunit gamma; Provisional; Region: PRK13253 718251000687 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 718251000688 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 718251000689 active site 718251000690 nucleotide binding site [chemical binding]; other site 718251000691 HIGH motif; other site 718251000692 KMSKS motif; other site 718251000693 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 718251000694 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718251000695 putative active site [active] 718251000696 heme pocket [chemical binding]; other site 718251000697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251000698 ATP binding site [chemical binding]; other site 718251000699 Mg2+ binding site [ion binding]; other site 718251000700 G-X-G motif; other site 718251000701 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 718251000702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251000703 active site 718251000704 phosphorylation site [posttranslational modification] 718251000705 intermolecular recognition site; other site 718251000706 dimerization interface [polypeptide binding]; other site 718251000707 Transcriptional regulator; Region: CitT; pfam12431 718251000708 LexA repressor; Validated; Region: PRK00215 718251000709 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 718251000710 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 718251000711 Catalytic site [active] 718251000712 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 718251000713 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 718251000714 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 718251000715 metal binding site 2 [ion binding]; metal-binding site 718251000716 putative DNA binding helix; other site 718251000717 metal binding site 1 [ion binding]; metal-binding site 718251000718 dimer interface [polypeptide binding]; other site 718251000719 structural Zn2+ binding site [ion binding]; other site 718251000720 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 718251000721 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 718251000722 FMN binding site [chemical binding]; other site 718251000723 active site 718251000724 catalytic residues [active] 718251000725 substrate binding site [chemical binding]; other site 718251000726 Phage shock protein G (Phageshock_PspG); Region: Phageshock_PspG; cl11511 718251000727 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 718251000728 replicative DNA helicase; Provisional; Region: PRK08006 718251000729 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 718251000730 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 718251000731 Walker A motif; other site 718251000732 ATP binding site [chemical binding]; other site 718251000733 Walker B motif; other site 718251000734 DNA binding loops [nucleotide binding] 718251000735 alanine racemase; Reviewed; Region: alr; PRK00053 718251000736 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 718251000737 active site 718251000738 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 718251000739 substrate binding site [chemical binding]; other site 718251000740 catalytic residues [active] 718251000741 dimer interface [polypeptide binding]; other site 718251000742 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 718251000743 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 718251000744 dimer interface [polypeptide binding]; other site 718251000745 active site 718251000746 metal binding site [ion binding]; metal-binding site 718251000747 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 718251000748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718251000749 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 718251000750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718251000751 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 718251000752 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 718251000753 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 718251000754 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 718251000755 E-class dimer interface [polypeptide binding]; other site 718251000756 P-class dimer interface [polypeptide binding]; other site 718251000757 active site 718251000758 Cu2+ binding site [ion binding]; other site 718251000759 Zn2+ binding site [ion binding]; other site 718251000760 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 718251000761 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 718251000762 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 718251000763 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 718251000764 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 718251000765 [4Fe-4S] binding site [ion binding]; other site 718251000766 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718251000767 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718251000768 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718251000769 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 718251000770 molybdopterin cofactor binding site; other site 718251000771 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 718251000772 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 718251000773 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 718251000774 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 718251000775 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 718251000776 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718251000777 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 718251000778 catalytic residue [active] 718251000779 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 718251000780 putrescine transporter; Provisional; Region: potE; PRK10655 718251000781 nickel responsive regulator; Provisional; Region: PRK02967 718251000782 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 718251000783 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 718251000784 murein transglycosylase C; Provisional; Region: mltC; PRK11671 718251000785 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 718251000786 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 718251000787 N-acetyl-D-glucosamine binding site [chemical binding]; other site 718251000788 catalytic residue [active] 718251000789 oxidative damage protection protein; Provisional; Region: PRK05408 718251000790 adenine DNA glycosylase; Provisional; Region: PRK10880 718251000791 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 718251000792 minor groove reading motif; other site 718251000793 helix-hairpin-helix signature motif; other site 718251000794 substrate binding pocket [chemical binding]; other site 718251000795 active site 718251000796 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 718251000797 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 718251000798 DNA binding and oxoG recognition site [nucleotide binding] 718251000799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251000800 S-adenosylmethionine binding site [chemical binding]; other site 718251000801 hypothetical protein; Provisional; Region: PRK11702 718251000802 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 718251000803 glutaminase; Provisional; Region: PRK00971 718251000804 hypothetical protein; Provisional; Region: PRK10626 718251000805 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 718251000806 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 718251000807 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 718251000808 peptide binding site [polypeptide binding]; other site 718251000809 HemN family oxidoreductase; Provisional; Region: PRK05660 718251000810 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718251000811 FeS/SAM binding site; other site 718251000812 HemN C-terminal domain; Region: HemN_C; pfam06969 718251000813 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 718251000814 active site 718251000815 dimerization interface [polypeptide binding]; other site 718251000816 hypothetical protein; Validated; Region: PRK05090 718251000817 YGGT family; Region: YGGT; pfam02325 718251000818 YGGT family; Region: YGGT; pfam02325 718251000819 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 718251000820 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 718251000821 catalytic residue [active] 718251000822 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 718251000823 hypothetical protein; Validated; Region: PRK00228 718251000824 glutathione synthetase; Provisional; Region: PRK05246 718251000825 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 718251000826 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 718251000827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 718251000828 RNA methyltransferase, RsmE family; Region: TIGR00046 718251000829 DNA-specific endonuclease I; Provisional; Region: PRK15137 718251000830 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 718251000831 hypothetical protein; Provisional; Region: PRK04860 718251000832 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 718251000833 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 718251000834 lysine decarboxylase CadA; Provisional; Region: PRK15400 718251000835 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 718251000836 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 718251000837 homodimer interface [polypeptide binding]; other site 718251000838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251000839 catalytic residue [active] 718251000840 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 718251000841 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 718251000842 hypothetical protein; Provisional; Region: PRK11653 718251000843 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 718251000844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718251000845 DNA-binding site [nucleotide binding]; DNA binding site 718251000846 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718251000847 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 718251000848 L-fuculokinase; Provisional; Region: PRK10331 718251000849 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 718251000850 nucleotide binding site [chemical binding]; other site 718251000851 L-fucose isomerase; Provisional; Region: fucI; PRK10991 718251000852 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 718251000853 hexamer (dimer of trimers) interface [polypeptide binding]; other site 718251000854 trimer interface [polypeptide binding]; other site 718251000855 substrate binding site [chemical binding]; other site 718251000856 Mn binding site [ion binding]; other site 718251000857 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 718251000858 L-fucose transporter; Provisional; Region: PRK10133; cl17665 718251000859 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 718251000860 intersubunit interface [polypeptide binding]; other site 718251000861 active site 718251000862 Zn2+ binding site [ion binding]; other site 718251000863 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 718251000864 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 718251000865 dimer interface [polypeptide binding]; other site 718251000866 active site 718251000867 metal binding site [ion binding]; metal-binding site 718251000868 acid-resistance membrane protein; Provisional; Region: PRK10209 718251000869 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 718251000870 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 718251000871 chaperone protein TorD; Validated; Region: torD; PRK04976 718251000872 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 718251000873 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 718251000874 molybdopterin cofactor binding site [chemical binding]; other site 718251000875 substrate binding site [chemical binding]; other site 718251000876 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 718251000877 molybdopterin cofactor binding site; other site 718251000878 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 718251000879 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 718251000880 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 718251000881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251000882 active site 718251000883 phosphorylation site [posttranslational modification] 718251000884 intermolecular recognition site; other site 718251000885 dimerization interface [polypeptide binding]; other site 718251000886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718251000887 DNA binding site [nucleotide binding] 718251000888 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 718251000889 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 718251000890 putative ligand binding site [chemical binding]; other site 718251000891 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 718251000892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251000893 dimer interface [polypeptide binding]; other site 718251000894 phosphorylation site [posttranslational modification] 718251000895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251000896 ATP binding site [chemical binding]; other site 718251000897 Mg2+ binding site [ion binding]; other site 718251000898 G-X-G motif; other site 718251000899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251000900 active site 718251000901 phosphorylation site [posttranslational modification] 718251000902 intermolecular recognition site; other site 718251000903 dimerization interface [polypeptide binding]; other site 718251000904 Hpt domain; Region: Hpt; pfam01627 718251000905 hypothetical protein; Provisional; Region: PRK10316 718251000906 YfdX protein; Region: YfdX; pfam10938 718251000907 putative transcriptional regulator; Provisional; Region: PRK11640 718251000908 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 718251000909 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 718251000910 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 718251000911 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 718251000912 DsbD alpha interface [polypeptide binding]; other site 718251000913 catalytic residues [active] 718251000914 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 718251000915 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 718251000916 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 718251000917 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 718251000918 Aspartase; Region: Aspartase; cd01357 718251000919 active sites [active] 718251000920 tetramer interface [polypeptide binding]; other site 718251000921 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 718251000922 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 718251000923 oligomerisation interface [polypeptide binding]; other site 718251000924 mobile loop; other site 718251000925 roof hairpin; other site 718251000926 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 718251000927 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 718251000928 ring oligomerisation interface [polypeptide binding]; other site 718251000929 ATP/Mg binding site [chemical binding]; other site 718251000930 stacking interactions; other site 718251000931 hinge regions; other site 718251000932 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 718251000933 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 718251000934 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 718251000935 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 718251000936 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 718251000937 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 718251000938 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 718251000939 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 718251000940 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 718251000941 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 718251000942 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 718251000943 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 718251000944 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 718251000945 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 718251000946 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 718251000947 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 718251000948 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 718251000949 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 718251000950 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 718251000951 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 718251000952 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 718251000953 HlyD family secretion protein; Region: HlyD_3; pfam13437 718251000954 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 718251000955 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 718251000956 Walker A/P-loop; other site 718251000957 ATP binding site [chemical binding]; other site 718251000958 Q-loop/lid; other site 718251000959 ABC transporter signature motif; other site 718251000960 Walker B; other site 718251000961 D-loop; other site 718251000962 H-loop/switch region; other site 718251000963 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 718251000964 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 718251000965 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 718251000966 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 718251000967 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 718251000968 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 718251000969 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 718251000970 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 718251000971 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 718251000972 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 718251000973 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 718251000974 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 718251000975 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 718251000976 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 718251000977 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 718251000978 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 718251000979 Uncharacterized conserved protein [Function unknown]; Region: COG1556 718251000980 iron-sulfur cluster-binding protein; Region: TIGR00273 718251000981 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 718251000982 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 718251000983 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 718251000984 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 718251000985 Cysteine-rich domain; Region: CCG; pfam02754 718251000986 Cysteine-rich domain; Region: CCG; pfam02754 718251000987 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 718251000988 L-lactate permease; Region: Lactate_perm; cl00701 718251000989 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 718251000990 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718251000991 FeS/SAM binding site; other site 718251000992 elongation factor P; Validated; Region: PRK00529 718251000993 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 718251000994 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 718251000995 RNA binding site [nucleotide binding]; other site 718251000996 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 718251000997 RNA binding site [nucleotide binding]; other site 718251000998 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 718251000999 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 718251001000 Iron-sulfur protein interface; other site 718251001001 proximal quinone binding site [chemical binding]; other site 718251001002 C-subunit interface; other site 718251001003 distal quinone binding site; other site 718251001004 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 718251001005 D-subunit interface [polypeptide binding]; other site 718251001006 Iron-sulfur protein interface; other site 718251001007 proximal quinone binding site [chemical binding]; other site 718251001008 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 718251001009 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 718251001010 catalytic loop [active] 718251001011 iron binding site [ion binding]; other site 718251001012 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 718251001013 L-aspartate oxidase; Provisional; Region: PRK06175 718251001014 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 718251001015 poxB regulator PoxA; Provisional; Region: PRK09350 718251001016 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 718251001017 motif 1; other site 718251001018 dimer interface [polypeptide binding]; other site 718251001019 active site 718251001020 motif 2; other site 718251001021 motif 3; other site 718251001022 putative mechanosensitive channel protein; Provisional; Region: PRK10929 718251001023 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 718251001024 Mechanosensitive ion channel; Region: MS_channel; pfam00924 718251001025 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 718251001026 GTPase RsgA; Reviewed; Region: PRK12288 718251001027 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 718251001028 RNA binding site [nucleotide binding]; other site 718251001029 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 718251001030 GTPase/Zn-binding domain interface [polypeptide binding]; other site 718251001031 GTP/Mg2+ binding site [chemical binding]; other site 718251001032 G4 box; other site 718251001033 G5 box; other site 718251001034 G1 box; other site 718251001035 Switch I region; other site 718251001036 G2 box; other site 718251001037 G3 box; other site 718251001038 Switch II region; other site 718251001039 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 718251001040 catalytic site [active] 718251001041 putative active site [active] 718251001042 putative substrate binding site [chemical binding]; other site 718251001043 dimer interface [polypeptide binding]; other site 718251001044 epoxyqueuosine reductase; Region: TIGR00276 718251001045 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 718251001046 putative carbohydrate kinase; Provisional; Region: PRK10565 718251001047 Uncharacterized conserved protein [Function unknown]; Region: COG0062 718251001048 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 718251001049 putative substrate binding site [chemical binding]; other site 718251001050 putative ATP binding site [chemical binding]; other site 718251001051 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 718251001052 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 718251001053 AMIN domain; Region: AMIN; pfam11741 718251001054 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 718251001055 active site 718251001056 metal binding site [ion binding]; metal-binding site 718251001057 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 718251001058 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 718251001059 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 718251001060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251001061 ATP binding site [chemical binding]; other site 718251001062 Mg2+ binding site [ion binding]; other site 718251001063 G-X-G motif; other site 718251001064 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 718251001065 ATP binding site [chemical binding]; other site 718251001066 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 718251001067 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 718251001068 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 718251001069 bacterial Hfq-like; Region: Hfq; cd01716 718251001070 hexamer interface [polypeptide binding]; other site 718251001071 Sm1 motif; other site 718251001072 RNA binding site [nucleotide binding]; other site 718251001073 Sm2 motif; other site 718251001074 GTPase HflX; Provisional; Region: PRK11058 718251001075 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 718251001076 HflX GTPase family; Region: HflX; cd01878 718251001077 G1 box; other site 718251001078 GTP/Mg2+ binding site [chemical binding]; other site 718251001079 Switch I region; other site 718251001080 G2 box; other site 718251001081 G3 box; other site 718251001082 Switch II region; other site 718251001083 G4 box; other site 718251001084 G5 box; other site 718251001085 FtsH protease regulator HflK; Provisional; Region: PRK10930 718251001086 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 718251001087 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 718251001088 FtsH protease regulator HflC; Provisional; Region: PRK11029 718251001089 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 718251001090 Transposase IS200 like; Region: Y1_Tnp; pfam01797 718251001091 Acyltransferase family; Region: Acyl_transf_3; pfam01757 718251001092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 718251001093 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 718251001094 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 718251001095 GDP-binding site [chemical binding]; other site 718251001096 ACT binding site; other site 718251001097 IMP binding site; other site 718251001098 transcriptional repressor NsrR; Provisional; Region: PRK11014 718251001099 Predicted transcriptional regulator [Transcription]; Region: COG1959 718251001100 exoribonuclease R; Provisional; Region: PRK11642 718251001101 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 718251001102 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 718251001103 RNB domain; Region: RNB; pfam00773 718251001104 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 718251001105 RNA binding site [nucleotide binding]; other site 718251001106 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 718251001107 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 718251001108 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 718251001109 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 718251001110 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 718251001111 esterase; Provisional; Region: PRK10566 718251001112 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 718251001113 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 718251001114 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 718251001115 dimer interface [polypeptide binding]; other site 718251001116 ssDNA binding site [nucleotide binding]; other site 718251001117 tetramer (dimer of dimers) interface [polypeptide binding]; other site 718251001118 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 718251001119 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 718251001120 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 718251001121 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 718251001122 Protein of unknown function, DUF488; Region: DUF488; cl01246 718251001123 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 718251001124 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 718251001125 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 718251001126 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 718251001127 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 718251001128 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 718251001129 Hemerythrin-like domain; Region: Hr-like; cd12108 718251001130 Fe binding site [ion binding]; other site 718251001131 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 718251001132 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 718251001133 active site 718251001134 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 718251001135 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 718251001136 Domain of unknown function DUF21; Region: DUF21; pfam01595 718251001137 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 718251001138 Transporter associated domain; Region: CorC_HlyC; smart01091 718251001139 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 718251001140 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 718251001141 Surface antigen; Region: Bac_surface_Ag; pfam01103 718251001142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 718251001143 Family of unknown function (DUF490); Region: DUF490; pfam04357 718251001144 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 718251001145 dimerization interface [polypeptide binding]; other site 718251001146 putative active site pocket [active] 718251001147 putative catalytic residue [active] 718251001148 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 718251001149 dimer interface [polypeptide binding]; other site 718251001150 substrate binding site [chemical binding]; other site 718251001151 metal binding sites [ion binding]; metal-binding site 718251001152 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 718251001153 AMP binding site [chemical binding]; other site 718251001154 metal binding site [ion binding]; metal-binding site 718251001155 active site 718251001156 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 718251001157 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 718251001158 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718251001159 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718251001160 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 718251001161 arginine repressor; Provisional; Region: PRK05066 718251001162 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 718251001163 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 718251001164 malate dehydrogenase; Provisional; Region: PRK05086 718251001165 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 718251001166 NAD binding site [chemical binding]; other site 718251001167 dimerization interface [polypeptide binding]; other site 718251001168 Substrate binding site [chemical binding]; other site 718251001169 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 718251001170 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 718251001171 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 718251001172 substrate binding pocket [chemical binding]; other site 718251001173 chain length determination region; other site 718251001174 substrate-Mg2+ binding site; other site 718251001175 catalytic residues [active] 718251001176 aspartate-rich region 1; other site 718251001177 active site lid residues [active] 718251001178 aspartate-rich region 2; other site 718251001179 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 718251001180 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 718251001181 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 718251001182 EamA-like transporter family; Region: EamA; pfam00892 718251001183 EamA-like transporter family; Region: EamA; pfam00892 718251001184 GTPase CgtA; Reviewed; Region: obgE; PRK12298 718251001185 GTP1/OBG; Region: GTP1_OBG; pfam01018 718251001186 Obg GTPase; Region: Obg; cd01898 718251001187 G1 box; other site 718251001188 GTP/Mg2+ binding site [chemical binding]; other site 718251001189 Switch I region; other site 718251001190 G2 box; other site 718251001191 G3 box; other site 718251001192 Switch II region; other site 718251001193 G4 box; other site 718251001194 G5 box; other site 718251001195 sensor protein BasS/PmrB; Provisional; Region: PRK10755 718251001196 HAMP domain; Region: HAMP; pfam00672 718251001197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251001198 dimer interface [polypeptide binding]; other site 718251001199 phosphorylation site [posttranslational modification] 718251001200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251001201 ATP binding site [chemical binding]; other site 718251001202 Mg2+ binding site [ion binding]; other site 718251001203 G-X-G motif; other site 718251001204 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 718251001205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251001206 active site 718251001207 phosphorylation site [posttranslational modification] 718251001208 intermolecular recognition site; other site 718251001209 dimerization interface [polypeptide binding]; other site 718251001210 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718251001211 DNA binding site [nucleotide binding] 718251001212 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 718251001213 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 718251001214 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 718251001215 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 718251001216 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 718251001217 RNA-binding protein YhbY; Provisional; Region: PRK10343 718251001218 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 718251001219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251001220 S-adenosylmethionine binding site [chemical binding]; other site 718251001221 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 718251001222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251001223 Walker A motif; other site 718251001224 ATP binding site [chemical binding]; other site 718251001225 Walker B motif; other site 718251001226 arginine finger; other site 718251001227 Peptidase family M41; Region: Peptidase_M41; pfam01434 718251001228 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 718251001229 dihydropteroate synthase; Region: DHPS; TIGR01496 718251001230 substrate binding pocket [chemical binding]; other site 718251001231 dimer interface [polypeptide binding]; other site 718251001232 inhibitor binding site; inhibition site 718251001233 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 718251001234 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 718251001235 active site 718251001236 substrate binding site [chemical binding]; other site 718251001237 metal binding site [ion binding]; metal-binding site 718251001238 Preprotein translocase SecG subunit; Region: SecG; pfam03840 718251001239 ribosome maturation protein RimP; Reviewed; Region: PRK00092 718251001240 hypothetical protein; Provisional; Region: PRK14641 718251001241 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 718251001242 putative oligomer interface [polypeptide binding]; other site 718251001243 putative RNA binding site [nucleotide binding]; other site 718251001244 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 718251001245 NusA N-terminal domain; Region: NusA_N; pfam08529 718251001246 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 718251001247 RNA binding site [nucleotide binding]; other site 718251001248 homodimer interface [polypeptide binding]; other site 718251001249 NusA-like KH domain; Region: KH_5; pfam13184 718251001250 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 718251001251 G-X-X-G motif; other site 718251001252 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 718251001253 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 718251001254 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 718251001255 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 718251001256 translation initiation factor IF-2; Validated; Region: infB; PRK05306 718251001257 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 718251001258 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 718251001259 G1 box; other site 718251001260 putative GEF interaction site [polypeptide binding]; other site 718251001261 GTP/Mg2+ binding site [chemical binding]; other site 718251001262 Switch I region; other site 718251001263 G2 box; other site 718251001264 G3 box; other site 718251001265 Switch II region; other site 718251001266 G4 box; other site 718251001267 G5 box; other site 718251001268 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 718251001269 Translation-initiation factor 2; Region: IF-2; pfam11987 718251001270 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 718251001271 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 718251001272 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 718251001273 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 718251001274 RNA binding site [nucleotide binding]; other site 718251001275 active site 718251001276 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 718251001277 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 718251001278 16S/18S rRNA binding site [nucleotide binding]; other site 718251001279 S13e-L30e interaction site [polypeptide binding]; other site 718251001280 25S rRNA binding site [nucleotide binding]; other site 718251001281 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 718251001282 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 718251001283 RNase E interface [polypeptide binding]; other site 718251001284 trimer interface [polypeptide binding]; other site 718251001285 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 718251001286 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 718251001287 RNase E interface [polypeptide binding]; other site 718251001288 trimer interface [polypeptide binding]; other site 718251001289 active site 718251001290 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 718251001291 putative nucleic acid binding region [nucleotide binding]; other site 718251001292 G-X-X-G motif; other site 718251001293 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 718251001294 RNA binding site [nucleotide binding]; other site 718251001295 domain interface; other site 718251001296 lipoprotein NlpI; Provisional; Region: PRK11189 718251001297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718251001298 binding surface 718251001299 TPR motif; other site 718251001300 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 718251001301 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 718251001302 ATP binding site [chemical binding]; other site 718251001303 Mg++ binding site [ion binding]; other site 718251001304 motif III; other site 718251001305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718251001306 nucleotide binding region [chemical binding]; other site 718251001307 ATP-binding site [chemical binding]; other site 718251001308 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 718251001309 putative RNA binding site [nucleotide binding]; other site 718251001310 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 718251001311 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 718251001312 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 718251001313 putative protease; Provisional; Region: PRK15447 718251001314 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 718251001315 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 718251001316 Peptidase family U32; Region: Peptidase_U32; pfam01136 718251001317 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 718251001318 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 718251001319 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718251001320 Coenzyme A binding pocket [chemical binding]; other site 718251001321 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 718251001322 Na binding site [ion binding]; other site 718251001323 hypothetical protein; Provisional; Region: PRK03467 718251001324 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 718251001325 NADH(P)-binding; Region: NAD_binding_10; pfam13460 718251001326 NAD binding site [chemical binding]; other site 718251001327 active site 718251001328 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121 718251001329 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 718251001330 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 718251001331 ATP cone domain; Region: ATP-cone; pfam03477 718251001332 Class III ribonucleotide reductase; Region: RNR_III; cd01675 718251001333 effector binding site; other site 718251001334 active site 718251001335 Zn binding site [ion binding]; other site 718251001336 glycine loop; other site 718251001337 YqjK-like protein; Region: YqjK; pfam13997 718251001338 Predicted membrane protein [Function unknown]; Region: COG5393 718251001339 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 718251001340 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 718251001341 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 718251001342 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 718251001343 CrcB-like protein; Region: CRCB; cl09114 718251001344 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 718251001345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718251001346 DNA-binding site [nucleotide binding]; DNA binding site 718251001347 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 718251001348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251001349 D-galactonate transporter; Region: 2A0114; TIGR00893 718251001350 putative substrate translocation pore; other site 718251001351 Glucuronate isomerase; Region: UxaC; pfam02614 718251001352 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 718251001353 altronate oxidoreductase; Provisional; Region: PRK03643 718251001354 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 718251001355 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 718251001356 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 718251001357 galactarate dehydratase; Region: galactar-dH20; TIGR03248 718251001358 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 718251001359 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 718251001360 serine/threonine transporter SstT; Provisional; Region: PRK13628 718251001361 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 718251001362 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 718251001363 EamA-like transporter family; Region: EamA; pfam00892 718251001364 EamA-like transporter family; Region: EamA; pfam00892 718251001365 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 718251001366 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 718251001367 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 718251001368 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 718251001369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251001370 S-adenosylmethionine binding site [chemical binding]; other site 718251001371 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 718251001372 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718251001373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251001374 homodimer interface [polypeptide binding]; other site 718251001375 catalytic residue [active] 718251001376 sensor protein QseC; Provisional; Region: PRK10337 718251001377 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 718251001378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251001379 dimer interface [polypeptide binding]; other site 718251001380 phosphorylation site [posttranslational modification] 718251001381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251001382 ATP binding site [chemical binding]; other site 718251001383 Mg2+ binding site [ion binding]; other site 718251001384 G-X-G motif; other site 718251001385 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 718251001386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251001387 active site 718251001388 phosphorylation site [posttranslational modification] 718251001389 intermolecular recognition site; other site 718251001390 dimerization interface [polypeptide binding]; other site 718251001391 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718251001392 DNA binding site [nucleotide binding] 718251001393 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 718251001394 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 718251001395 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 718251001396 dimer interface [polypeptide binding]; other site 718251001397 active site 718251001398 glycine loop; other site 718251001399 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 718251001400 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718251001401 FeS/SAM binding site; other site 718251001402 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 718251001403 active site 718251001404 intersubunit interactions; other site 718251001405 catalytic residue [active] 718251001406 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 718251001407 active site 718251001408 SUMO-1 interface [polypeptide binding]; other site 718251001409 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 718251001410 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 718251001411 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 718251001412 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 718251001413 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 718251001414 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 718251001415 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 718251001416 DNA binding residues [nucleotide binding] 718251001417 DNA primase; Validated; Region: dnaG; PRK05667 718251001418 CHC2 zinc finger; Region: zf-CHC2; pfam01807 718251001419 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 718251001420 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 718251001421 active site 718251001422 metal binding site [ion binding]; metal-binding site 718251001423 interdomain interaction site; other site 718251001424 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 718251001425 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 718251001426 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 718251001427 UGMP family protein; Validated; Region: PRK09604 718251001428 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 718251001429 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 718251001430 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 718251001431 homooctamer interface [polypeptide binding]; other site 718251001432 active site 718251001433 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 718251001434 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 718251001435 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 718251001436 active site 718251001437 NTP binding site [chemical binding]; other site 718251001438 metal binding triad [ion binding]; metal-binding site 718251001439 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 718251001440 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 718251001441 Zn2+ binding site [ion binding]; other site 718251001442 Mg2+ binding site [ion binding]; other site 718251001443 SH3 domain-containing protein; Provisional; Region: PRK10884 718251001444 Bacterial SH3 domain homologues; Region: SH3b; smart00287 718251001445 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 718251001446 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 718251001447 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 718251001448 Uncharacterized conserved protein [Function unknown]; Region: COG3025 718251001449 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 718251001450 putative active site [active] 718251001451 putative triphosphate binding site [ion binding]; other site 718251001452 putative metal binding residues [ion binding]; other site 718251001453 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 718251001454 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 718251001455 metal binding triad; other site 718251001456 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 718251001457 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 718251001458 metal binding triad; other site 718251001459 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 718251001460 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 718251001461 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 718251001462 putative acyl-acceptor binding pocket; other site 718251001463 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 718251001464 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 718251001465 putative ribose interaction site [chemical binding]; other site 718251001466 putative ADP binding site [chemical binding]; other site 718251001467 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 718251001468 active site 718251001469 nucleotide binding site [chemical binding]; other site 718251001470 HIGH motif; other site 718251001471 KMSKS motif; other site 718251001472 putative transporter; Provisional; Region: PRK11021 718251001473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 718251001474 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 718251001475 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 718251001476 zinc transporter ZupT; Provisional; Region: PRK04201 718251001477 ZIP Zinc transporter; Region: Zip; pfam02535 718251001478 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 718251001479 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 718251001480 putative active site [active] 718251001481 metal binding site [ion binding]; metal-binding site 718251001482 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 718251001483 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 718251001484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251001485 S-adenosylmethionine binding site [chemical binding]; other site 718251001486 DNA polymerase III subunit psi; Validated; Region: PRK06856 718251001487 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 718251001488 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 718251001489 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 718251001490 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 718251001491 G1 box; other site 718251001492 putative GEF interaction site [polypeptide binding]; other site 718251001493 GTP/Mg2+ binding site [chemical binding]; other site 718251001494 Switch I region; other site 718251001495 G2 box; other site 718251001496 G3 box; other site 718251001497 Switch II region; other site 718251001498 G4 box; other site 718251001499 G5 box; other site 718251001500 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 718251001501 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 718251001502 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 718251001503 active site 718251001504 nucleophile elbow; other site 718251001505 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 718251001506 active site 718251001507 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 718251001508 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 718251001509 Nucleoside recognition; Region: Gate; pfam07670 718251001510 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 718251001511 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 718251001512 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 718251001513 hypothetical protein; Provisional; Region: PRK10977 718251001514 Pyruvate formate lyase; Region: PFL; pfam02901 718251001515 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 718251001516 intersubunit interface [polypeptide binding]; other site 718251001517 active site 718251001518 catalytic residue [active] 718251001519 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 718251001520 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 718251001521 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 718251001522 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 718251001523 phosphopentomutase; Provisional; Region: PRK05362 718251001524 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 718251001525 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 718251001526 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 718251001527 Cytochrome b562; Region: Cytochrom_B562; cl01546 718251001528 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 718251001529 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 718251001530 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 718251001531 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 718251001532 dimerization domain swap beta strand [polypeptide binding]; other site 718251001533 regulatory protein interface [polypeptide binding]; other site 718251001534 active site 718251001535 regulatory phosphorylation site [posttranslational modification]; other site 718251001536 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 718251001537 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 718251001538 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 718251001539 active site 718251001540 phosphorylation site [posttranslational modification] 718251001541 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 718251001542 30S subunit binding site; other site 718251001543 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 718251001544 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 718251001545 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 718251001546 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 718251001547 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 718251001548 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 718251001549 Walker A/P-loop; other site 718251001550 ATP binding site [chemical binding]; other site 718251001551 Q-loop/lid; other site 718251001552 ABC transporter signature motif; other site 718251001553 Walker B; other site 718251001554 D-loop; other site 718251001555 H-loop/switch region; other site 718251001556 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 718251001557 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 718251001558 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 718251001559 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 718251001560 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 718251001561 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 718251001562 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 718251001563 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 718251001564 putative active site [active] 718251001565 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 718251001566 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 718251001567 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 718251001568 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 718251001569 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 718251001570 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 718251001571 Walker A/P-loop; other site 718251001572 ATP binding site [chemical binding]; other site 718251001573 Q-loop/lid; other site 718251001574 ABC transporter signature motif; other site 718251001575 Walker B; other site 718251001576 D-loop; other site 718251001577 H-loop/switch region; other site 718251001578 conserved hypothetical integral membrane protein; Region: TIGR00056 718251001579 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 718251001580 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 718251001581 mce related protein; Region: MCE; pfam02470 718251001582 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 718251001583 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 718251001584 anti sigma factor interaction site; other site 718251001585 regulatory phosphorylation site [posttranslational modification]; other site 718251001586 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 718251001587 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 718251001588 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 718251001589 hinge; other site 718251001590 active site 718251001591 serine endoprotease; Provisional; Region: PRK10898 718251001592 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 718251001593 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 718251001594 serine endoprotease; Provisional; Region: PRK10139 718251001595 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 718251001596 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 718251001597 protein binding site [polypeptide binding]; other site 718251001598 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 718251001599 protein binding site [polypeptide binding]; other site 718251001600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 718251001601 hypothetical protein; Provisional; Region: PRK11677 718251001602 Predicted ATPase [General function prediction only]; Region: COG1485 718251001603 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 718251001604 23S rRNA interface [nucleotide binding]; other site 718251001605 L3 interface [polypeptide binding]; other site 718251001606 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 718251001607 stringent starvation protein A; Provisional; Region: sspA; PRK09481 718251001608 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 718251001609 C-terminal domain interface [polypeptide binding]; other site 718251001610 putative GSH binding site (G-site) [chemical binding]; other site 718251001611 dimer interface [polypeptide binding]; other site 718251001612 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 718251001613 dimer interface [polypeptide binding]; other site 718251001614 N-terminal domain interface [polypeptide binding]; other site 718251001615 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 718251001616 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 718251001617 N-acetylmannosamine kinase; Provisional; Region: PRK05082 718251001618 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 718251001619 nucleotide binding site [chemical binding]; other site 718251001620 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 718251001621 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 718251001622 putative active site cavity [active] 718251001623 putative disulfide oxidoreductase; Provisional; Region: PRK04307 718251001624 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 718251001625 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 718251001626 catalytic residues [active] 718251001627 hinge region; other site 718251001628 alpha helical domain; other site 718251001629 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 718251001630 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718251001631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251001632 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 718251001633 substrate binding pocket [chemical binding]; other site 718251001634 dimerization interface [polypeptide binding]; other site 718251001635 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 718251001636 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 718251001637 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 718251001638 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718251001639 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718251001640 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 718251001641 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 718251001642 active site 718251001643 dimer interface [polypeptide binding]; other site 718251001644 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 718251001645 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 718251001646 active site 718251001647 FMN binding site [chemical binding]; other site 718251001648 substrate binding site [chemical binding]; other site 718251001649 3Fe-4S cluster binding site [ion binding]; other site 718251001650 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 718251001651 domain interface; other site 718251001652 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 718251001653 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718251001654 FeS/SAM binding site; other site 718251001655 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 718251001656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718251001657 putative active site [active] 718251001658 heme pocket [chemical binding]; other site 718251001659 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251001660 dimer interface [polypeptide binding]; other site 718251001661 phosphorylation site [posttranslational modification] 718251001662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251001663 ATP binding site [chemical binding]; other site 718251001664 Mg2+ binding site [ion binding]; other site 718251001665 G-X-G motif; other site 718251001666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251001667 active site 718251001668 phosphorylation site [posttranslational modification] 718251001669 intermolecular recognition site; other site 718251001670 dimerization interface [polypeptide binding]; other site 718251001671 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 718251001672 putative binding surface; other site 718251001673 active site 718251001674 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 718251001675 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 718251001676 conserved cys residue [active] 718251001677 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 718251001678 Transglycosylase; Region: Transgly; cl17702 718251001679 outer membrane lipoprotein; Provisional; Region: PRK11023 718251001680 BON domain; Region: BON; pfam04972 718251001681 BON domain; Region: BON; pfam04972 718251001682 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 718251001683 dimer interface [polypeptide binding]; other site 718251001684 active site 718251001685 hypothetical protein; Reviewed; Region: PRK12497 718251001686 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 718251001687 putative ligand binding site [chemical binding]; other site 718251001688 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 718251001689 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 718251001690 putative SAM binding site [chemical binding]; other site 718251001691 putative homodimer interface [polypeptide binding]; other site 718251001692 hypothetical protein; Provisional; Region: PRK11246 718251001693 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 718251001694 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 718251001695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251001696 motif II; other site 718251001697 DNA repair protein RadA; Provisional; Region: PRK11823 718251001698 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 718251001699 Walker A motif/ATP binding site; other site 718251001700 ATP binding site [chemical binding]; other site 718251001701 Walker B motif; other site 718251001702 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 718251001703 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 718251001704 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718251001705 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718251001706 ABC transporter; Region: ABC_tran_2; pfam12848 718251001707 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718251001708 lytic murein transglycosylase; Provisional; Region: PRK11619 718251001709 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 718251001710 N-acetyl-D-glucosamine binding site [chemical binding]; other site 718251001711 catalytic residue [active] 718251001712 Trp operon repressor; Provisional; Region: PRK01381 718251001713 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 718251001714 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 718251001715 catalytic core [active] 718251001716 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 718251001717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718251001718 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 718251001719 hypothetical protein; Provisional; Region: PRK10756 718251001720 CreA protein; Region: CreA; pfam05981 718251001721 prolyl-tRNA synthetase; Provisional; Region: PRK09194 718251001722 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 718251001723 dimer interface [polypeptide binding]; other site 718251001724 motif 1; other site 718251001725 active site 718251001726 motif 2; other site 718251001727 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 718251001728 putative deacylase active site [active] 718251001729 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 718251001730 active site 718251001731 motif 3; other site 718251001732 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 718251001733 anticodon binding site; other site 718251001734 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 718251001735 homodimer interaction site [polypeptide binding]; other site 718251001736 cofactor binding site; other site 718251001737 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 718251001738 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 718251001739 lipoprotein, YaeC family; Region: TIGR00363 718251001740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251001741 dimer interface [polypeptide binding]; other site 718251001742 conserved gate region; other site 718251001743 ABC-ATPase subunit interface; other site 718251001744 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 718251001745 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 718251001746 Walker A/P-loop; other site 718251001747 ATP binding site [chemical binding]; other site 718251001748 Q-loop/lid; other site 718251001749 ABC transporter signature motif; other site 718251001750 Walker B; other site 718251001751 D-loop; other site 718251001752 H-loop/switch region; other site 718251001753 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 718251001754 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 718251001755 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251001756 active site 718251001757 motif I; other site 718251001758 motif II; other site 718251001759 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 718251001760 Mechanosensitive ion channel; Region: MS_channel; pfam00924 718251001761 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 718251001762 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 718251001763 domain interface [polypeptide binding]; other site 718251001764 putative active site [active] 718251001765 catalytic site [active] 718251001766 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 718251001767 domain interface [polypeptide binding]; other site 718251001768 putative active site [active] 718251001769 catalytic site [active] 718251001770 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 718251001771 CoA binding domain; Region: CoA_binding_2; pfam13380 718251001772 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 718251001773 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 718251001774 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 718251001775 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 718251001776 Uncharacterized conserved protein [Function unknown]; Region: COG3148 718251001777 thioredoxin 2; Provisional; Region: PRK10996 718251001778 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 718251001779 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 718251001780 catalytic residues [active] 718251001781 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 718251001782 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 718251001783 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 718251001784 two-component response regulator; Provisional; Region: PRK11173 718251001785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251001786 active site 718251001787 phosphorylation site [posttranslational modification] 718251001788 intermolecular recognition site; other site 718251001789 dimerization interface [polypeptide binding]; other site 718251001790 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718251001791 DNA binding site [nucleotide binding] 718251001792 putative RNA methyltransferase; Provisional; Region: PRK10433 718251001793 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 718251001794 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 718251001795 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 718251001796 substrate binding site [chemical binding]; other site 718251001797 nucleotide binding site [chemical binding]; other site 718251001798 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 718251001799 dimer interface [polypeptide binding]; other site 718251001800 putative threonine allosteric regulatory site; other site 718251001801 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 718251001802 putative threonine allosteric regulatory site; other site 718251001803 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 718251001804 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 718251001805 homoserine kinase; Provisional; Region: PRK01212 718251001806 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 718251001807 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 718251001808 threonine synthase; Validated; Region: PRK09225 718251001809 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 718251001810 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718251001811 catalytic residue [active] 718251001812 hypothetical protein; Validated; Region: PRK02101 718251001813 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 718251001814 amino acid carrier protein; Region: agcS; TIGR00835 718251001815 transaldolase-like protein; Provisional; Region: PTZ00411 718251001816 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 718251001817 active site 718251001818 dimer interface [polypeptide binding]; other site 718251001819 catalytic residue [active] 718251001820 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 718251001821 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 718251001822 tetramerization interface [polypeptide binding]; other site 718251001823 NAD(P) binding site [chemical binding]; other site 718251001824 catalytic residues [active] 718251001825 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 718251001826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251001827 active site 718251001828 motif I; other site 718251001829 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 718251001830 MPT binding site; other site 718251001831 trimer interface [polypeptide binding]; other site 718251001832 metabolite-proton symporter; Region: 2A0106; TIGR00883 718251001833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251001834 putative substrate translocation pore; other site 718251001835 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 718251001836 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 718251001837 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 718251001838 nucleotide binding site [chemical binding]; other site 718251001839 chaperone protein DnaJ; Provisional; Region: PRK10767 718251001840 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 718251001841 HSP70 interaction site [polypeptide binding]; other site 718251001842 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 718251001843 substrate binding site [polypeptide binding]; other site 718251001844 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 718251001845 Zn binding sites [ion binding]; other site 718251001846 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 718251001847 dimer interface [polypeptide binding]; other site 718251001848 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 718251001849 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 718251001850 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251001851 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 718251001852 putative dimerization interface [polypeptide binding]; other site 718251001853 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 718251001854 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 718251001855 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 718251001856 active site 718251001857 Riboflavin kinase; Region: Flavokinase; smart00904 718251001858 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 718251001859 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 718251001860 active site 718251001861 HIGH motif; other site 718251001862 nucleotide binding site [chemical binding]; other site 718251001863 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 718251001864 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 718251001865 active site 718251001866 KMSKS motif; other site 718251001867 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 718251001868 tRNA binding surface [nucleotide binding]; other site 718251001869 anticodon binding site; other site 718251001870 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 718251001871 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 718251001872 lipoprotein signal peptidase; Provisional; Region: PRK14787 718251001873 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 718251001874 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 718251001875 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 718251001876 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 718251001877 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 718251001878 substrate binding site [chemical binding]; other site 718251001879 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 718251001880 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 718251001881 catalytic loop [active] 718251001882 iron binding site [ion binding]; other site 718251001883 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 718251001884 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 718251001885 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 718251001886 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 718251001887 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 718251001888 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 718251001889 dihydrodipicolinate reductase; Provisional; Region: PRK00048 718251001890 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 718251001891 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 718251001892 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 718251001893 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 718251001894 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 718251001895 catalytic site [active] 718251001896 subunit interface [polypeptide binding]; other site 718251001897 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 718251001898 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 718251001899 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 718251001900 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 718251001901 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 718251001902 ATP-grasp domain; Region: ATP-grasp_4; cl17255 718251001903 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 718251001904 IMP binding site; other site 718251001905 dimer interface [polypeptide binding]; other site 718251001906 interdomain contacts; other site 718251001907 partial ornithine binding site; other site 718251001908 Uncharacterized conserved protein [Function unknown]; Region: COG2966 718251001909 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 718251001910 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 718251001911 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 718251001912 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 718251001913 folate binding site [chemical binding]; other site 718251001914 NADP+ binding site [chemical binding]; other site 718251001915 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 718251001916 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 718251001917 active site 718251001918 metal binding site [ion binding]; metal-binding site 718251001919 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 718251001920 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 718251001921 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 718251001922 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 718251001923 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 718251001924 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 718251001925 SurA N-terminal domain; Region: SurA_N; pfam09312 718251001926 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 718251001927 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 718251001928 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 718251001929 OstA-like protein; Region: OstA; pfam03968 718251001930 Organic solvent tolerance protein; Region: OstA_C; pfam04453 718251001931 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 718251001932 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 718251001933 putative metal binding site [ion binding]; other site 718251001934 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 718251001935 HSP70 interaction site [polypeptide binding]; other site 718251001936 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 718251001937 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 718251001938 active site 718251001939 ATP-dependent helicase HepA; Validated; Region: PRK04914 718251001940 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718251001941 ATP binding site [chemical binding]; other site 718251001942 putative Mg++ binding site [ion binding]; other site 718251001943 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718251001944 nucleotide binding region [chemical binding]; other site 718251001945 ATP-binding site [chemical binding]; other site 718251001946 DNA polymerase II; Reviewed; Region: PRK05762 718251001947 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 718251001948 active site 718251001949 catalytic site [active] 718251001950 substrate binding site [chemical binding]; other site 718251001951 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 718251001952 active site 718251001953 metal-binding site 718251001954 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 718251001955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251001956 Walker A/P-loop; other site 718251001957 ATP binding site [chemical binding]; other site 718251001958 Q-loop/lid; other site 718251001959 ABC transporter signature motif; other site 718251001960 Walker B; other site 718251001961 D-loop; other site 718251001962 H-loop/switch region; other site 718251001963 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 718251001964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251001965 dimer interface [polypeptide binding]; other site 718251001966 conserved gate region; other site 718251001967 putative PBP binding loops; other site 718251001968 ABC-ATPase subunit interface; other site 718251001969 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 718251001970 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 718251001971 transcriptional regulator SgrR; Provisional; Region: PRK13626 718251001972 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 718251001973 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 718251001974 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 718251001975 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 718251001976 transmembrane helices; other site 718251001977 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 718251001978 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 718251001979 Walker A/P-loop; other site 718251001980 ATP binding site [chemical binding]; other site 718251001981 Q-loop/lid; other site 718251001982 ABC transporter signature motif; other site 718251001983 Walker B; other site 718251001984 D-loop; other site 718251001985 H-loop/switch region; other site 718251001986 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 718251001987 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 718251001988 Walker A/P-loop; other site 718251001989 ATP binding site [chemical binding]; other site 718251001990 Q-loop/lid; other site 718251001991 ABC transporter signature motif; other site 718251001992 Walker B; other site 718251001993 D-loop; other site 718251001994 H-loop/switch region; other site 718251001995 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 718251001996 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 718251001997 siderophore binding site; other site 718251001998 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 718251001999 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718251002000 ABC-ATPase subunit interface; other site 718251002001 dimer interface [polypeptide binding]; other site 718251002002 putative PBP binding regions; other site 718251002003 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718251002004 ABC-ATPase subunit interface; other site 718251002005 dimer interface [polypeptide binding]; other site 718251002006 putative PBP binding regions; other site 718251002007 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 718251002008 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718251002009 N-terminal plug; other site 718251002010 ligand-binding site [chemical binding]; other site 718251002011 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 718251002012 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 718251002013 substrate binding site [chemical binding]; other site 718251002014 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 718251002015 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 718251002016 substrate binding site [chemical binding]; other site 718251002017 ligand binding site [chemical binding]; other site 718251002018 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 718251002019 tartrate dehydrogenase; Provisional; Region: PRK08194 718251002020 2-isopropylmalate synthase; Validated; Region: PRK00915 718251002021 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 718251002022 active site 718251002023 catalytic residues [active] 718251002024 metal binding site [ion binding]; metal-binding site 718251002025 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 718251002026 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 718251002027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251002028 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 718251002029 putative substrate binding pocket [chemical binding]; other site 718251002030 putative dimerization interface [polypeptide binding]; other site 718251002031 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 718251002032 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 718251002033 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 718251002034 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 718251002035 acyl-activating enzyme (AAE) consensus motif; other site 718251002036 acyl-activating enzyme (AAE) consensus motif; other site 718251002037 putative AMP binding site [chemical binding]; other site 718251002038 putative active site [active] 718251002039 putative CoA binding site [chemical binding]; other site 718251002040 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 718251002041 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 718251002042 PYR/PP interface [polypeptide binding]; other site 718251002043 dimer interface [polypeptide binding]; other site 718251002044 TPP binding site [chemical binding]; other site 718251002045 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 718251002046 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 718251002047 TPP-binding site [chemical binding]; other site 718251002048 dimer interface [polypeptide binding]; other site 718251002049 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 718251002050 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 718251002051 putative valine binding site [chemical binding]; other site 718251002052 dimer interface [polypeptide binding]; other site 718251002053 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 718251002054 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 718251002055 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718251002056 DNA binding site [nucleotide binding] 718251002057 domain linker motif; other site 718251002058 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 718251002059 dimerization interface [polypeptide binding]; other site 718251002060 ligand binding site [chemical binding]; other site 718251002061 MraZ protein; Region: MraZ; pfam02381 718251002062 MraZ protein; Region: MraZ; pfam02381 718251002063 MraW methylase family; Region: Methyltransf_5; pfam01795 718251002064 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 718251002065 cell division protein FtsL; Provisional; Region: PRK10772 718251002066 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 718251002067 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 718251002068 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 718251002069 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 718251002070 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 718251002071 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718251002072 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718251002073 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 718251002074 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 718251002075 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718251002076 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718251002077 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 718251002078 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 718251002079 Mg++ binding site [ion binding]; other site 718251002080 putative catalytic motif [active] 718251002081 putative substrate binding site [chemical binding]; other site 718251002082 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 718251002083 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718251002084 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718251002085 cell division protein FtsW; Provisional; Region: PRK10774 718251002086 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 718251002087 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 718251002088 active site 718251002089 homodimer interface [polypeptide binding]; other site 718251002090 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 718251002091 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 718251002092 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718251002093 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 718251002094 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 718251002095 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 718251002096 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 718251002097 cell division protein FtsQ; Provisional; Region: PRK10775 718251002098 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 718251002099 Cell division protein FtsQ; Region: FtsQ; pfam03799 718251002100 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 718251002101 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 718251002102 Cell division protein FtsA; Region: FtsA; pfam14450 718251002103 cell division protein FtsZ; Validated; Region: PRK09330 718251002104 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 718251002105 nucleotide binding site [chemical binding]; other site 718251002106 SulA interaction site; other site 718251002107 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 718251002108 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 718251002109 Protein of unknown function (DUF721); Region: DUF721; cl02324 718251002110 SecA regulator SecM; Provisional; Region: PRK02943 718251002111 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 718251002112 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 718251002113 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 718251002114 nucleotide binding region [chemical binding]; other site 718251002115 ATP-binding site [chemical binding]; other site 718251002116 SEC-C motif; Region: SEC-C; pfam02810 718251002117 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 718251002118 active site 718251002119 8-oxo-dGMP binding site [chemical binding]; other site 718251002120 nudix motif; other site 718251002121 metal binding site [ion binding]; metal-binding site 718251002122 DNA gyrase inhibitor; Reviewed; Region: PRK00418 718251002123 hypothetical protein; Provisional; Region: PRK05287 718251002124 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 718251002125 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 718251002126 CoA-binding site [chemical binding]; other site 718251002127 ATP-binding [chemical binding]; other site 718251002128 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 718251002129 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 718251002130 active site 718251002131 type IV pilin biogenesis protein; Provisional; Region: PRK10573 718251002132 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 718251002133 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 718251002134 hypothetical protein; Provisional; Region: PRK10436 718251002135 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 718251002136 Walker A motif; other site 718251002137 ATP binding site [chemical binding]; other site 718251002138 Walker B motif; other site 718251002139 putative major pilin subunit; Provisional; Region: PRK10574 718251002140 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 718251002141 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 718251002142 amidase catalytic site [active] 718251002143 Zn binding residues [ion binding]; other site 718251002144 substrate binding site [chemical binding]; other site 718251002145 regulatory protein AmpE; Provisional; Region: PRK10987 718251002146 aromatic amino acid transporter; Provisional; Region: PRK10238 718251002147 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 718251002148 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718251002149 DNA-binding site [nucleotide binding]; DNA binding site 718251002150 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 718251002151 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 718251002152 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 718251002153 dimer interface [polypeptide binding]; other site 718251002154 TPP-binding site [chemical binding]; other site 718251002155 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 718251002156 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 718251002157 E3 interaction surface; other site 718251002158 lipoyl attachment site [posttranslational modification]; other site 718251002159 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 718251002160 E3 interaction surface; other site 718251002161 lipoyl attachment site [posttranslational modification]; other site 718251002162 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 718251002163 E3 interaction surface; other site 718251002164 lipoyl attachment site [posttranslational modification]; other site 718251002165 e3 binding domain; Region: E3_binding; pfam02817 718251002166 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 718251002167 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 718251002168 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 718251002169 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718251002170 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 718251002171 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 718251002172 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 718251002173 substrate binding site [chemical binding]; other site 718251002174 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 718251002175 substrate binding site [chemical binding]; other site 718251002176 ligand binding site [chemical binding]; other site 718251002177 Protein of unknown function (DUF533); Region: DUF533; pfam04391 718251002178 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 718251002179 putative metal binding site [ion binding]; other site 718251002180 hypothetical protein; Provisional; Region: PRK05248 718251002181 aromatic amino acid exporter; Provisional; Region: PRK11689 718251002182 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 718251002183 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718251002184 active site 718251002185 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 718251002186 active site clefts [active] 718251002187 zinc binding site [ion binding]; other site 718251002188 dimer interface [polypeptide binding]; other site 718251002189 DNA-binding response regulator CreB; Provisional; Region: PRK11083 718251002190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251002191 active site 718251002192 phosphorylation site [posttranslational modification] 718251002193 intermolecular recognition site; other site 718251002194 dimerization interface [polypeptide binding]; other site 718251002195 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718251002196 DNA binding site [nucleotide binding] 718251002197 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 718251002198 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 718251002199 Walker A/P-loop; other site 718251002200 ATP binding site [chemical binding]; other site 718251002201 Q-loop/lid; other site 718251002202 ABC transporter signature motif; other site 718251002203 Walker B; other site 718251002204 D-loop; other site 718251002205 H-loop/switch region; other site 718251002206 inner membrane transport permease; Provisional; Region: PRK15066 718251002207 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 718251002208 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 718251002209 active site 718251002210 active pocket/dimerization site; other site 718251002211 phosphorylation site [posttranslational modification] 718251002212 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 718251002213 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 718251002214 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718251002215 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 718251002216 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 718251002217 dimer interface [polypeptide binding]; other site 718251002218 active site 718251002219 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 718251002220 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 718251002221 active site 718251002222 phosphorylation site [posttranslational modification] 718251002223 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 718251002224 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 718251002225 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 718251002226 putative active site [active] 718251002227 putative metal binding site [ion binding]; other site 718251002228 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 718251002229 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 718251002230 tetramerization interface [polypeptide binding]; other site 718251002231 active site 718251002232 pantoate--beta-alanine ligase; Region: panC; TIGR00018 718251002233 Pantoate-beta-alanine ligase; Region: PanC; cd00560 718251002234 active site 718251002235 ATP-binding site [chemical binding]; other site 718251002236 pantoate-binding site; other site 718251002237 HXXH motif; other site 718251002238 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 718251002239 oligomerization interface [polypeptide binding]; other site 718251002240 active site 718251002241 metal binding site [ion binding]; metal-binding site 718251002242 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 718251002243 catalytic center binding site [active] 718251002244 ATP binding site [chemical binding]; other site 718251002245 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 718251002246 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 718251002247 active site 718251002248 NTP binding site [chemical binding]; other site 718251002249 metal binding triad [ion binding]; metal-binding site 718251002250 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 718251002251 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 718251002252 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 718251002253 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 718251002254 active site 718251002255 nucleotide binding site [chemical binding]; other site 718251002256 HIGH motif; other site 718251002257 KMSKS motif; other site 718251002258 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 718251002259 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 718251002260 2'-5' RNA ligase; Provisional; Region: PRK15124 718251002261 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 718251002262 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 718251002263 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 718251002264 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718251002265 ATP binding site [chemical binding]; other site 718251002266 putative Mg++ binding site [ion binding]; other site 718251002267 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718251002268 nucleotide binding region [chemical binding]; other site 718251002269 ATP-binding site [chemical binding]; other site 718251002270 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 718251002271 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 718251002272 Transglycosylase; Region: Transgly; pfam00912 718251002273 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 718251002274 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 718251002275 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 718251002276 trimer interface [polypeptide binding]; other site 718251002277 eyelet of channel; other site 718251002278 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 718251002279 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 718251002280 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 718251002281 metal binding site [ion binding]; metal-binding site 718251002282 hypothetical protein; Provisional; Region: PRK10726 718251002283 FlxA-like protein; Region: FlxA; pfam14282 718251002284 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 718251002285 thymidylate synthase; Reviewed; Region: thyA; PRK01827 718251002286 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 718251002287 dimerization interface [polypeptide binding]; other site 718251002288 active site 718251002289 hypothetical protein; Provisional; Region: PRK10506 718251002290 hypothetical protein; Provisional; Region: PRK10557 718251002291 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 718251002292 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 718251002293 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 718251002294 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 718251002295 protease3; Provisional; Region: PRK15101 718251002296 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 718251002297 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 718251002298 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 718251002299 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 718251002300 AAA domain; Region: AAA_30; pfam13604 718251002301 Family description; Region: UvrD_C_2; pfam13538 718251002302 N-acetylglutamate synthase; Validated; Region: PRK05279 718251002303 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 718251002304 putative feedback inhibition sensing region; other site 718251002305 putative nucleotide binding site [chemical binding]; other site 718251002306 putative substrate binding site [chemical binding]; other site 718251002307 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718251002308 Coenzyme A binding pocket [chemical binding]; other site 718251002309 AMIN domain; Region: AMIN; pfam11741 718251002310 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 718251002311 active site 718251002312 metal binding site [ion binding]; metal-binding site 718251002313 murein transglycosylase A; Provisional; Region: mltA; PRK11162 718251002314 MltA specific insert domain; Region: MltA; pfam03562 718251002315 3D domain; Region: 3D; pfam06725 718251002316 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 718251002317 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 718251002318 putative ATP binding site [chemical binding]; other site 718251002319 putative substrate interface [chemical binding]; other site 718251002320 Fe-S metabolism associated domain; Region: SufE; cl00951 718251002321 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 718251002322 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 718251002323 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718251002324 catalytic residue [active] 718251002325 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 718251002326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251002327 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 718251002328 dimerization interface [polypeptide binding]; other site 718251002329 substrate binding pocket [chemical binding]; other site 718251002330 hypothetical protein; Provisional; Region: PRK10873 718251002331 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 718251002332 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 718251002333 flap endonuclease-like protein; Provisional; Region: PRK09482 718251002334 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 718251002335 active site 718251002336 metal binding site 1 [ion binding]; metal-binding site 718251002337 putative 5' ssDNA interaction site; other site 718251002338 metal binding site 3; metal-binding site 718251002339 metal binding site 2 [ion binding]; metal-binding site 718251002340 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 718251002341 putative DNA binding site [nucleotide binding]; other site 718251002342 putative metal binding site [ion binding]; other site 718251002343 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 718251002344 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 718251002345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 718251002346 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 718251002347 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 718251002348 SecY interacting protein Syd; Provisional; Region: PRK04968 718251002349 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 718251002350 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 718251002351 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 718251002352 probable active site [active] 718251002353 flavodoxin; Provisional; Region: PRK08105 718251002354 hypothetical protein; Provisional; Region: PRK13677 718251002355 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 718251002356 Domain of unknown function (DUF305); Region: DUF305; cl17794 718251002357 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 718251002358 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 718251002359 trimer interface [polypeptide binding]; other site 718251002360 active site 718251002361 substrate binding site [chemical binding]; other site 718251002362 CoA binding site [chemical binding]; other site 718251002363 PII uridylyl-transferase; Provisional; Region: PRK05007 718251002364 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 718251002365 metal binding triad; other site 718251002366 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 718251002367 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 718251002368 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 718251002369 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 718251002370 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 718251002371 active site 718251002372 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 718251002373 rRNA interaction site [nucleotide binding]; other site 718251002374 S8 interaction site; other site 718251002375 putative laminin-1 binding site; other site 718251002376 elongation factor Ts; Provisional; Region: tsf; PRK09377 718251002377 UBA/TS-N domain; Region: UBA; pfam00627 718251002378 Elongation factor TS; Region: EF_TS; pfam00889 718251002379 Elongation factor TS; Region: EF_TS; pfam00889 718251002380 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 718251002381 putative nucleotide binding site [chemical binding]; other site 718251002382 uridine monophosphate binding site [chemical binding]; other site 718251002383 homohexameric interface [polypeptide binding]; other site 718251002384 ribosome recycling factor; Reviewed; Region: frr; PRK00083 718251002385 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 718251002386 hinge region; other site 718251002387 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 718251002388 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 718251002389 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 718251002390 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 718251002391 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 718251002392 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 718251002393 catalytic residue [active] 718251002394 putative FPP diphosphate binding site; other site 718251002395 putative FPP binding hydrophobic cleft; other site 718251002396 dimer interface [polypeptide binding]; other site 718251002397 putative IPP diphosphate binding site; other site 718251002398 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 718251002399 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 718251002400 zinc metallopeptidase RseP; Provisional; Region: PRK10779 718251002401 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 718251002402 active site 718251002403 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 718251002404 protein binding site [polypeptide binding]; other site 718251002405 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 718251002406 protein binding site [polypeptide binding]; other site 718251002407 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 718251002408 putative substrate binding region [chemical binding]; other site 718251002409 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 718251002410 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718251002411 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718251002412 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718251002413 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718251002414 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 718251002415 Surface antigen; Region: Bac_surface_Ag; pfam01103 718251002416 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 718251002417 periplasmic chaperone; Provisional; Region: PRK10780 718251002418 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 718251002419 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 718251002420 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 718251002421 trimer interface [polypeptide binding]; other site 718251002422 active site 718251002423 UDP-GlcNAc binding site [chemical binding]; other site 718251002424 lipid binding site [chemical binding]; lipid-binding site 718251002425 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 718251002426 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 718251002427 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 718251002428 active site 718251002429 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 718251002430 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 718251002431 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 718251002432 RNA/DNA hybrid binding site [nucleotide binding]; other site 718251002433 active site 718251002434 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 718251002435 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 718251002436 putative active site [active] 718251002437 putative PHP Thumb interface [polypeptide binding]; other site 718251002438 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 718251002439 generic binding surface II; other site 718251002440 generic binding surface I; other site 718251002441 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 718251002442 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 718251002443 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 718251002444 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 718251002445 putative metal binding site [ion binding]; other site 718251002446 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718251002447 DNA binding site [nucleotide binding] 718251002448 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 718251002449 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 718251002450 lysine decarboxylase CadA; Provisional; Region: PRK15400 718251002451 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 718251002452 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 718251002453 homodimer interface [polypeptide binding]; other site 718251002454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251002455 catalytic residue [active] 718251002456 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 718251002457 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 718251002458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251002459 putative substrate translocation pore; other site 718251002460 POT family; Region: PTR2; pfam00854 718251002461 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 718251002462 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 718251002463 Ligand Binding Site [chemical binding]; other site 718251002464 TilS substrate binding domain; Region: TilS; pfam09179 718251002465 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 718251002466 Cytochrome c553 [Energy production and conversion]; Region: COG2863 718251002467 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 718251002468 hypothetical protein; Provisional; Region: PRK04964 718251002469 YaeQ protein; Region: YaeQ; pfam07152 718251002470 hypothetical protein; Provisional; Region: PRK09256 718251002471 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 718251002472 NlpE N-terminal domain; Region: NlpE; pfam04170 718251002473 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 718251002474 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 718251002475 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 718251002476 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 718251002477 putative active site [active] 718251002478 hypothetical protein; Provisional; Region: PRK11590 718251002479 putative alcohol dehydrogenase; Provisional; Region: PRK09860 718251002480 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 718251002481 dimer interface [polypeptide binding]; other site 718251002482 active site 718251002483 metal binding site [ion binding]; metal-binding site 718251002484 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 718251002485 active site residue [active] 718251002486 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 718251002487 nucleoside/Zn binding site; other site 718251002488 dimer interface [polypeptide binding]; other site 718251002489 catalytic motif [active] 718251002490 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 718251002491 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718251002492 substrate binding pocket [chemical binding]; other site 718251002493 membrane-bound complex binding site; other site 718251002494 hinge residues; other site 718251002495 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 718251002496 N-acetyl-D-glucosamine binding site [chemical binding]; other site 718251002497 catalytic residue [active] 718251002498 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 718251002499 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 718251002500 dimerization interface [polypeptide binding]; other site 718251002501 ATP binding site [chemical binding]; other site 718251002502 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 718251002503 dimerization interface [polypeptide binding]; other site 718251002504 ATP binding site [chemical binding]; other site 718251002505 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 718251002506 putative active site [active] 718251002507 catalytic triad [active] 718251002508 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 718251002509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251002510 dimer interface [polypeptide binding]; other site 718251002511 phosphorylation site [posttranslational modification] 718251002512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251002513 Mg2+ binding site [ion binding]; other site 718251002514 G-X-G motif; other site 718251002515 hypothetical protein; Provisional; Region: PRK10722 718251002516 response regulator GlrR; Provisional; Region: PRK15115 718251002517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251002518 active site 718251002519 phosphorylation site [posttranslational modification] 718251002520 intermolecular recognition site; other site 718251002521 dimerization interface [polypeptide binding]; other site 718251002522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251002523 Walker A motif; other site 718251002524 ATP binding site [chemical binding]; other site 718251002525 Walker B motif; other site 718251002526 arginine finger; other site 718251002527 NAD synthetase; Provisional; Region: PRK13981 718251002528 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 718251002529 multimer interface [polypeptide binding]; other site 718251002530 active site 718251002531 catalytic triad [active] 718251002532 protein interface 1 [polypeptide binding]; other site 718251002533 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 718251002534 homodimer interface [polypeptide binding]; other site 718251002535 NAD binding pocket [chemical binding]; other site 718251002536 ATP binding pocket [chemical binding]; other site 718251002537 Mg binding site [ion binding]; other site 718251002538 active-site loop [active] 718251002539 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 718251002540 Nitrogen regulatory protein P-II; Region: P-II; smart00938 718251002541 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 718251002542 active site 718251002543 dimer interface [polypeptide binding]; other site 718251002544 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 718251002545 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 718251002546 putative active site [active] 718251002547 putative dimer interface [polypeptide binding]; other site 718251002548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 718251002549 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 718251002550 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 718251002551 ApbE family; Region: ApbE; pfam02424 718251002552 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 718251002553 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 718251002554 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 718251002555 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718251002556 catalytic residue [active] 718251002557 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 718251002558 active site 718251002559 DNA polymerase IV; Validated; Region: PRK02406 718251002560 DNA binding site [nucleotide binding] 718251002561 peptidase T; Region: peptidase-T; TIGR01882 718251002562 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 718251002563 metal binding site [ion binding]; metal-binding site 718251002564 dimer interface [polypeptide binding]; other site 718251002565 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 718251002566 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 718251002567 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 718251002568 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 718251002569 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 718251002570 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 718251002571 metal binding site [ion binding]; metal-binding site 718251002572 dimer interface [polypeptide binding]; other site 718251002573 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718251002574 active site 718251002575 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 718251002576 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 718251002577 gamma-glutamyl kinase; Provisional; Region: PRK05429 718251002578 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 718251002579 nucleotide binding site [chemical binding]; other site 718251002580 homotetrameric interface [polypeptide binding]; other site 718251002581 putative phosphate binding site [ion binding]; other site 718251002582 putative allosteric binding site; other site 718251002583 PUA domain; Region: PUA; pfam01472 718251002584 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 718251002585 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 718251002586 putative catalytic cysteine [active] 718251002587 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 718251002588 Prostaglandin dehydrogenases; Region: PGDH; cd05288 718251002589 NAD(P) binding site [chemical binding]; other site 718251002590 substrate binding site [chemical binding]; other site 718251002591 dimer interface [polypeptide binding]; other site 718251002592 integrase; Provisional; Region: PRK09692 718251002593 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 718251002594 active site 718251002595 Int/Topo IB signature motif; other site 718251002596 AAA ATPase domain; Region: AAA_15; pfam13175 718251002597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251002598 Walker A/P-loop; other site 718251002599 ATP binding site [chemical binding]; other site 718251002600 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 718251002601 putative active site [active] 718251002602 putative metal-binding site [ion binding]; other site 718251002603 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 718251002604 Part of AAA domain; Region: AAA_19; pfam13245 718251002605 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 718251002606 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 718251002607 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 718251002608 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 718251002609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 718251002610 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 718251002611 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 718251002612 D5 N terminal like; Region: D5_N; smart00885 718251002613 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 718251002614 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 718251002615 integrase; Provisional; Region: PRK09692 718251002616 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 718251002617 active site 718251002618 Int/Topo IB signature motif; other site 718251002619 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 718251002620 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 718251002621 catalytic tetrad [active] 718251002622 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 718251002623 putative transposase OrfB; Reviewed; Region: PHA02517 718251002624 HTH-like domain; Region: HTH_21; pfam13276 718251002625 Integrase core domain; Region: rve; pfam00665 718251002626 Integrase core domain; Region: rve_3; pfam13683 718251002627 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 718251002628 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 718251002629 Transposase; Region: DEDD_Tnp_IS110; pfam01548 718251002630 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 718251002631 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 718251002632 G1 box; other site 718251002633 GTP/Mg2+ binding site [chemical binding]; other site 718251002634 G2 box; other site 718251002635 Switch I region; other site 718251002636 G3 box; other site 718251002637 Switch II region; other site 718251002638 G4 box; other site 718251002639 Integrase core domain; Region: rve; pfam00665 718251002640 Integrase core domain; Region: rve_3; pfam13683 718251002641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 718251002642 Transposase; Region: HTH_Tnp_1; pfam01527 718251002643 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 718251002644 haemagglutination activity domain; Region: Haemagg_act; pfam05860 718251002645 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 718251002646 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 718251002647 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 718251002648 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 718251002649 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 718251002650 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 718251002651 dimer interface [polypeptide binding]; other site 718251002652 active site 718251002653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718251002654 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 718251002655 NAD(P) binding site [chemical binding]; other site 718251002656 active site 718251002657 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 718251002658 putative active site 1 [active] 718251002659 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 718251002660 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 718251002661 dimer interface [polypeptide binding]; other site 718251002662 active site 718251002663 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 718251002664 Predicted exporter [General function prediction only]; Region: COG4258 718251002665 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 718251002666 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 718251002667 active site 718251002668 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 718251002669 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 718251002670 Ligand binding site; other site 718251002671 Putative Catalytic site; other site 718251002672 DXD motif; other site 718251002673 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 718251002674 putative acyl-acceptor binding pocket; other site 718251002675 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 718251002676 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 718251002677 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 718251002678 acyl-activating enzyme (AAE) consensus motif; other site 718251002679 AMP binding site [chemical binding]; other site 718251002680 active site 718251002681 CoA binding site [chemical binding]; other site 718251002682 Predicted membrane protein [Function unknown]; Region: COG4648 718251002683 acyl carrier protein; Provisional; Region: PRK05350 718251002684 Phosphopantetheine attachment site; Region: PP-binding; cl09936 718251002685 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 718251002686 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 718251002687 putative acyl-acceptor binding pocket; other site 718251002688 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 718251002689 Methyltransferase domain; Region: Methyltransf_18; pfam12847 718251002690 S-adenosylmethionine binding site [chemical binding]; other site 718251002691 tryptophan permease TnaB; Provisional; Region: PRK09664 718251002692 aromatic amino acid transport protein; Region: araaP; TIGR00837 718251002693 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 718251002694 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 718251002695 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718251002696 catalytic residue [active] 718251002697 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 718251002698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251002699 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 718251002700 dimerization interface [polypeptide binding]; other site 718251002701 substrate binding pocket [chemical binding]; other site 718251002702 permease DsdX; Provisional; Region: PRK09921 718251002703 gluconate transporter; Region: gntP; TIGR00791 718251002704 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 718251002705 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 718251002706 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718251002707 catalytic residue [active] 718251002708 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 718251002709 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 718251002710 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 718251002711 Moco binding site; other site 718251002712 metal coordination site [ion binding]; other site 718251002713 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 718251002714 guanine deaminase; Region: guan_deamin; TIGR02967 718251002715 active site 718251002716 type III secretion system protein SsaL; Provisional; Region: PRK15345 718251002717 HrpJ-like domain; Region: HrpJ; pfam07201 718251002718 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 718251002719 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 718251002720 Type III secretion needle MxiH like; Region: MxiH; pfam09392 718251002721 Protein of unknown function (DUF1039); Region: DUF1039; pfam06287 718251002722 Type III secretion needle MxiH like; Region: MxiH; cl09641 718251002723 Helix-turn-helix domain; Region: HTH_18; pfam12833 718251002724 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718251002725 Protein of unknown function (DUF1895); Region: DUF1895; cl07553 718251002726 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 718251002727 type III secretion system protein SsaD; Provisional; Region: PRK15367 718251002728 outer membrane secretin SsaC; Provisional; Region: PRK15346 718251002729 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 718251002730 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 718251002731 pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357 718251002732 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 718251002733 Tetratricopeptide repeat; Region: TPR_3; pfam07720 718251002734 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 718251002735 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 718251002736 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 718251002737 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 718251002738 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718251002739 binding surface 718251002740 TPR motif; other site 718251002741 EspA-like secreted protein; Region: EspA; pfam03433 718251002742 hypothetical protein; Provisional; Region: PRK11820 718251002743 type III secretion system protein SsaQ; Validated; Region: PRK08035 718251002744 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 718251002745 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 718251002746 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 718251002747 Walker A motif; other site 718251002748 ATP binding site [chemical binding]; other site 718251002749 Walker B motif; other site 718251002750 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 718251002751 FHIPEP family; Region: FHIPEP; pfam00771 718251002752 type III secretion system protein SsaM; Provisional; Region: PRK15353 718251002753 type III secretion system protein YscR; Provisional; Region: PRK12797 718251002754 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 718251002755 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 718251002756 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 718251002757 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 718251002758 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 718251002759 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 718251002760 N-acetyl-D-glucosamine binding site [chemical binding]; other site 718251002761 catalytic residue [active] 718251002762 two component system sensor kinase SsrA; Provisional; Region: PRK15347 718251002763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251002764 dimer interface [polypeptide binding]; other site 718251002765 phosphorylation site [posttranslational modification] 718251002766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251002767 ATP binding site [chemical binding]; other site 718251002768 Mg2+ binding site [ion binding]; other site 718251002769 G-X-G motif; other site 718251002770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251002771 active site 718251002772 phosphorylation site [posttranslational modification] 718251002773 intermolecular recognition site; other site 718251002774 dimerization interface [polypeptide binding]; other site 718251002775 Hpt domain; Region: Hpt; pfam01627 718251002776 putative binding surface; other site 718251002777 active site 718251002778 two component system sensor kinase SsrB; Provisional; Region: PRK15369 718251002779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251002780 active site 718251002781 phosphorylation site [posttranslational modification] 718251002782 intermolecular recognition site; other site 718251002783 dimerization interface [polypeptide binding]; other site 718251002784 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718251002785 DNA binding residues [nucleotide binding] 718251002786 dimerization interface [polypeptide binding]; other site 718251002787 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 718251002788 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 718251002789 dimer interface [polypeptide binding]; other site 718251002790 active site 718251002791 heme binding site [chemical binding]; other site 718251002792 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 718251002793 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 718251002794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251002795 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718251002796 dimerization interface [polypeptide binding]; other site 718251002797 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 718251002798 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 718251002799 tetramer interface [polypeptide binding]; other site 718251002800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251002801 catalytic residue [active] 718251002802 threonine/serine transporter TdcC; Provisional; Region: PRK13629 718251002803 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 718251002804 propionate/acetate kinase; Provisional; Region: PRK12379 718251002805 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 718251002806 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 718251002807 Pyruvate formate lyase 1; Region: PFL1; cd01678 718251002808 coenzyme A binding site [chemical binding]; other site 718251002809 active site 718251002810 catalytic residues [active] 718251002811 glycine loop; other site 718251002812 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 718251002813 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 718251002814 dimer interface [polypeptide binding]; other site 718251002815 active site 718251002816 metal binding site [ion binding]; metal-binding site 718251002817 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 718251002818 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 718251002819 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 718251002820 active site 718251002821 metal binding site [ion binding]; metal-binding site 718251002822 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 718251002823 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 718251002824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251002825 dimer interface [polypeptide binding]; other site 718251002826 putative PBP binding loops; other site 718251002827 ABC-ATPase subunit interface; other site 718251002828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251002829 dimer interface [polypeptide binding]; other site 718251002830 conserved gate region; other site 718251002831 putative PBP binding loops; other site 718251002832 ABC-ATPase subunit interface; other site 718251002833 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 718251002834 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 718251002835 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 718251002836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251002837 Walker A/P-loop; other site 718251002838 ATP binding site [chemical binding]; other site 718251002839 Q-loop/lid; other site 718251002840 ABC transporter signature motif; other site 718251002841 Walker B; other site 718251002842 D-loop; other site 718251002843 H-loop/switch region; other site 718251002844 TOBE domain; Region: TOBE_2; pfam08402 718251002845 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 718251002846 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 718251002847 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 718251002848 haemagglutination activity domain; Region: Haemagg_act; pfam05860 718251002849 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 718251002850 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 718251002851 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 718251002852 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 718251002853 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 718251002854 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 718251002855 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 718251002856 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 718251002857 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 718251002858 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 718251002859 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 718251002860 dimer interface [polypeptide binding]; other site 718251002861 active site 718251002862 glycine loop; other site 718251002863 pyruvate formate lyase II activase; Provisional; Region: PRK10076 718251002864 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 718251002865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718251002866 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 718251002867 dimer interface [polypeptide binding]; other site 718251002868 FMN binding site [chemical binding]; other site 718251002869 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 718251002870 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 718251002871 putative active site [active] 718251002872 cell density-dependent motility repressor; Provisional; Region: PRK10082 718251002873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251002874 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 718251002875 dimerization interface [polypeptide binding]; other site 718251002876 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 718251002877 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 718251002878 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 718251002879 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 718251002880 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 718251002881 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 718251002882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251002883 putative PBP binding loops; other site 718251002884 ABC-ATPase subunit interface; other site 718251002885 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 718251002886 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251002887 ATP binding site [chemical binding]; other site 718251002888 Q-loop/lid; other site 718251002889 ABC transporter signature motif; other site 718251002890 Walker B; other site 718251002891 D-loop; other site 718251002892 H-loop/switch region; other site 718251002893 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 718251002894 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 718251002895 Class I aldolases; Region: Aldolase_Class_I; cl17187 718251002896 catalytic residue [active] 718251002897 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 718251002898 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 718251002899 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 718251002900 putative active site [active] 718251002901 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 718251002902 Na binding site [ion binding]; other site 718251002903 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 718251002904 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 718251002905 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 718251002906 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 718251002907 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 718251002908 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718251002909 HlyD family secretion protein; Region: HlyD_3; pfam13437 718251002910 Fusaric acid resistance protein family; Region: FUSC; pfam04632 718251002911 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 718251002912 dUMP phosphatase; Provisional; Region: PRK09449 718251002913 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251002914 motif II; other site 718251002915 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 718251002916 molybdenum-pterin binding domain; Region: Mop; TIGR00638 718251002917 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 718251002918 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 718251002919 putative chaperone; Provisional; Region: PRK11678 718251002920 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 718251002921 nucleotide binding site [chemical binding]; other site 718251002922 putative NEF/HSP70 interaction site [polypeptide binding]; other site 718251002923 SBD interface [polypeptide binding]; other site 718251002924 PAS domain S-box; Region: sensory_box; TIGR00229 718251002925 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718251002926 putative active site [active] 718251002927 heme pocket [chemical binding]; other site 718251002928 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718251002929 PAS domain; Region: PAS_9; pfam13426 718251002930 putative active site [active] 718251002931 heme pocket [chemical binding]; other site 718251002932 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 718251002933 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718251002934 metal binding site [ion binding]; metal-binding site 718251002935 active site 718251002936 I-site; other site 718251002937 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718251002938 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 718251002939 MgtE intracellular N domain; Region: MgtE_N; pfam03448 718251002940 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 718251002941 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 718251002942 MASE1; Region: MASE1; cl17823 718251002943 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 718251002944 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718251002945 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 718251002946 putative proline-specific permease; Provisional; Region: proY; PRK10580 718251002947 Spore germination protein; Region: Spore_permease; cl17796 718251002948 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 718251002949 Mechanosensitive ion channel; Region: MS_channel; pfam00924 718251002950 maltodextrin glucosidase; Provisional; Region: PRK10785 718251002951 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 718251002952 homodimer interface [polypeptide binding]; other site 718251002953 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 718251002954 active site 718251002955 homodimer interface [polypeptide binding]; other site 718251002956 catalytic site [active] 718251002957 peroxidase; Provisional; Region: PRK15000 718251002958 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 718251002959 dimer interface [polypeptide binding]; other site 718251002960 decamer (pentamer of dimers) interface [polypeptide binding]; other site 718251002961 catalytic triad [active] 718251002962 peroxidatic and resolving cysteines [active] 718251002963 Protein of unknown function, DUF479; Region: DUF479; cl01203 718251002964 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 718251002965 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 718251002966 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 718251002967 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 718251002968 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 718251002969 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 718251002970 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 718251002971 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 718251002972 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 718251002973 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 718251002974 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 718251002975 Protein export membrane protein; Region: SecD_SecF; pfam02355 718251002976 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251002977 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 718251002978 Walker A motif; other site 718251002979 ATP binding site [chemical binding]; other site 718251002980 Walker B motif; other site 718251002981 arginine finger; other site 718251002982 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 718251002983 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 718251002984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251002985 putative substrate translocation pore; other site 718251002986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251002987 EthD domain; Region: EthD; cl17553 718251002988 EthD domain; Region: EthD; cl17553 718251002989 EthD domain; Region: EthD; cl17553 718251002990 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 718251002991 classical (c) SDRs; Region: SDR_c; cd05233 718251002992 NAD(P) binding site [chemical binding]; other site 718251002993 active site 718251002994 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 718251002995 classical (c) SDRs; Region: SDR_c; cd05233 718251002996 NAD(P) binding site [chemical binding]; other site 718251002997 active site 718251002998 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 718251002999 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 718251003000 active site 718251003001 FMN binding site [chemical binding]; other site 718251003002 substrate binding site [chemical binding]; other site 718251003003 putative catalytic residue [active] 718251003004 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 718251003005 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718251003006 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 718251003007 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 718251003008 active site 718251003009 FMN binding site [chemical binding]; other site 718251003010 substrate binding site [chemical binding]; other site 718251003011 putative catalytic residue [active] 718251003012 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 718251003013 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718251003014 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 718251003015 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 718251003016 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718251003017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251003018 homodimer interface [polypeptide binding]; other site 718251003019 catalytic residue [active] 718251003020 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 718251003021 ATP cone domain; Region: ATP-cone; pfam03477 718251003022 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 718251003023 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 718251003024 catalytic motif [active] 718251003025 Zn binding site [ion binding]; other site 718251003026 RibD C-terminal domain; Region: RibD_C; cl17279 718251003027 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 718251003028 homopentamer interface [polypeptide binding]; other site 718251003029 active site 718251003030 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 718251003031 putative RNA binding site [nucleotide binding]; other site 718251003032 thiamine monophosphate kinase; Provisional; Region: PRK05731 718251003033 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 718251003034 ATP binding site [chemical binding]; other site 718251003035 dimerization interface [polypeptide binding]; other site 718251003036 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 718251003037 tetramer interfaces [polypeptide binding]; other site 718251003038 binuclear metal-binding site [ion binding]; other site 718251003039 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 718251003040 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 718251003041 TPP-binding site; other site 718251003042 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 718251003043 PYR/PP interface [polypeptide binding]; other site 718251003044 dimer interface [polypeptide binding]; other site 718251003045 TPP binding site [chemical binding]; other site 718251003046 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 718251003047 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 718251003048 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 718251003049 substrate binding pocket [chemical binding]; other site 718251003050 chain length determination region; other site 718251003051 substrate-Mg2+ binding site; other site 718251003052 catalytic residues [active] 718251003053 aspartate-rich region 1; other site 718251003054 active site lid residues [active] 718251003055 aspartate-rich region 2; other site 718251003056 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 718251003057 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 718251003058 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 718251003059 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 718251003060 Ligand Binding Site [chemical binding]; other site 718251003061 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 718251003062 active site residue [active] 718251003063 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 718251003064 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 718251003065 conserved cys residue [active] 718251003066 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 718251003067 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 718251003068 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 718251003069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 718251003070 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 718251003071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251003072 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718251003073 putative substrate translocation pore; other site 718251003074 muropeptide transporter; Reviewed; Region: ampG; PRK11902 718251003075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251003076 putative substrate translocation pore; other site 718251003077 hypothetical protein; Provisional; Region: PRK11627 718251003078 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 718251003079 transcriptional regulator BolA; Provisional; Region: PRK11628 718251003080 trigger factor; Provisional; Region: tig; PRK01490 718251003081 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 718251003082 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 718251003083 Clp protease; Region: CLP_protease; pfam00574 718251003084 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 718251003085 oligomer interface [polypeptide binding]; other site 718251003086 active site residues [active] 718251003087 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 718251003088 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 718251003089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251003090 Walker A motif; other site 718251003091 ATP binding site [chemical binding]; other site 718251003092 Walker B motif; other site 718251003093 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 718251003094 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 718251003095 Found in ATP-dependent protease La (LON); Region: LON; smart00464 718251003096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251003097 Walker A motif; other site 718251003098 ATP binding site [chemical binding]; other site 718251003099 Walker B motif; other site 718251003100 arginine finger; other site 718251003101 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 718251003102 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 718251003103 IHF dimer interface [polypeptide binding]; other site 718251003104 IHF - DNA interface [nucleotide binding]; other site 718251003105 periplasmic folding chaperone; Provisional; Region: PRK10788 718251003106 SurA N-terminal domain; Region: SurA_N_3; cl07813 718251003107 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 718251003108 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 718251003109 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 718251003110 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 718251003111 Ligand Binding Site [chemical binding]; other site 718251003112 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 718251003113 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 718251003114 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 718251003115 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 718251003116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 718251003117 active site 718251003118 motif I; other site 718251003119 motif II; other site 718251003120 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 718251003121 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 718251003122 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 718251003123 putative DNA binding site [nucleotide binding]; other site 718251003124 putative Zn2+ binding site [ion binding]; other site 718251003125 AsnC family; Region: AsnC_trans_reg; pfam01037 718251003126 Nitrogen regulatory protein P-II; Region: P-II; cl00412 718251003127 Nitrogen regulatory protein P-II; Region: P-II; smart00938 718251003128 ammonium transporter; Provisional; Region: PRK10666 718251003129 acyl-CoA thioesterase II; Provisional; Region: PRK10526 718251003130 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 718251003131 active site 718251003132 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 718251003133 catalytic triad [active] 718251003134 dimer interface [polypeptide binding]; other site 718251003135 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 718251003136 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 718251003137 DNA binding site [nucleotide binding] 718251003138 active site 718251003139 gene expression modulator; Provisional; Region: PRK10945 718251003140 Hha toxicity attenuator; Provisional; Region: PRK10667 718251003141 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 718251003142 Protein export membrane protein; Region: SecD_SecF; cl14618 718251003143 Protein export membrane protein; Region: SecD_SecF; cl14618 718251003144 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 718251003145 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718251003146 HlyD family secretion protein; Region: HlyD_3; pfam13437 718251003147 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 718251003148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718251003149 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 718251003150 DsrE/DsrF-like family; Region: DrsE; cl00672 718251003151 hypothetical protein; Provisional; Region: PRK11281 718251003152 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 718251003153 Mechanosensitive ion channel; Region: MS_channel; pfam00924 718251003154 hypothetical protein; Provisional; Region: PRK11038 718251003155 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 718251003156 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 718251003157 hypothetical protein; Provisional; Region: PRK10527 718251003158 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718251003159 active site 718251003160 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 718251003161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251003162 Walker A motif; other site 718251003163 ATP binding site [chemical binding]; other site 718251003164 Walker B motif; other site 718251003165 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 718251003166 arginine finger; other site 718251003167 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 718251003168 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 718251003169 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 718251003170 hypothetical protein; Validated; Region: PRK00153 718251003171 recombination protein RecR; Reviewed; Region: recR; PRK00076 718251003172 RecR protein; Region: RecR; pfam02132 718251003173 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 718251003174 putative active site [active] 718251003175 putative metal-binding site [ion binding]; other site 718251003176 tetramer interface [polypeptide binding]; other site 718251003177 heat shock protein 90; Provisional; Region: PRK05218 718251003178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251003179 ATP binding site [chemical binding]; other site 718251003180 Mg2+ binding site [ion binding]; other site 718251003181 G-X-G motif; other site 718251003182 adenylate kinase; Reviewed; Region: adk; PRK00279 718251003183 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 718251003184 AMP-binding site [chemical binding]; other site 718251003185 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 718251003186 ferrochelatase; Reviewed; Region: hemH; PRK00035 718251003187 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 718251003188 C-terminal domain interface [polypeptide binding]; other site 718251003189 active site 718251003190 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 718251003191 active site 718251003192 N-terminal domain interface [polypeptide binding]; other site 718251003193 inosine/guanosine kinase; Provisional; Region: PRK15074 718251003194 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 718251003195 substrate binding site [chemical binding]; other site 718251003196 ATP binding site [chemical binding]; other site 718251003197 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 718251003198 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 718251003199 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 718251003200 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 718251003201 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 718251003202 PapC N-terminal domain; Region: PapC_N; pfam13954 718251003203 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 718251003204 PapC C-terminal domain; Region: PapC_C; pfam13953 718251003205 Fimbrial protein; Region: Fimbrial; pfam00419 718251003206 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 718251003207 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 718251003208 active site 718251003209 metal binding site [ion binding]; metal-binding site 718251003210 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 718251003211 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 718251003212 putative deacylase active site [active] 718251003213 fructuronate transporter; Provisional; Region: PRK10034 718251003214 gluconate transporter; Region: gntP; TIGR00791 718251003215 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 718251003216 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718251003217 DNA-binding site [nucleotide binding]; DNA binding site 718251003218 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 718251003219 TraB family; Region: TraB; cl12050 718251003220 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 718251003221 metal-binding site [ion binding] 718251003222 copper exporting ATPase; Provisional; Region: copA; PRK10671 718251003223 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 718251003224 metal-binding site [ion binding] 718251003225 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 718251003226 metal-binding site [ion binding] 718251003227 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 718251003228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251003229 motif II; other site 718251003230 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 718251003231 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 718251003232 DNA binding residues [nucleotide binding] 718251003233 dimer interface [polypeptide binding]; other site 718251003234 copper binding site [ion binding]; other site 718251003235 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 718251003236 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 718251003237 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 718251003238 HutD; Region: HutD; pfam05962 718251003239 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 718251003240 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 718251003241 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 718251003242 MFS_1 like family; Region: MFS_1_like; pfam12832 718251003243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718251003244 active site 718251003245 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 718251003246 active site 718251003247 D-lactate dehydrogenase; Provisional; Region: PRK11183 718251003248 FAD binding domain; Region: FAD_binding_4; pfam01565 718251003249 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 718251003250 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 718251003251 dimerization interface [polypeptide binding]; other site 718251003252 putative DNA binding site [nucleotide binding]; other site 718251003253 putative Zn2+ binding site [ion binding]; other site 718251003254 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 718251003255 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718251003256 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 718251003257 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 718251003258 active site residue [active] 718251003259 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 718251003260 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251003261 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 718251003262 putative dimerization interface [polypeptide binding]; other site 718251003263 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 718251003264 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 718251003265 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 718251003266 tetramer interface [polypeptide binding]; other site 718251003267 active site 718251003268 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 718251003269 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 718251003270 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718251003271 catalytic residue [active] 718251003272 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 718251003273 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 718251003274 active site 718251003275 homotetramer interface [polypeptide binding]; other site 718251003276 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 718251003277 substrate binding site [chemical binding]; other site 718251003278 multimerization interface [polypeptide binding]; other site 718251003279 ATP binding site [chemical binding]; other site 718251003280 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 718251003281 dimer interface [polypeptide binding]; other site 718251003282 substrate binding site [chemical binding]; other site 718251003283 ATP binding site [chemical binding]; other site 718251003284 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 718251003285 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 718251003286 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 718251003287 catalytic residues [active] 718251003288 hinge region; other site 718251003289 alpha helical domain; other site 718251003290 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 718251003291 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251003292 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718251003293 putative protease; Provisional; Region: PRK15452 718251003294 Peptidase family U32; Region: Peptidase_U32; pfam01136 718251003295 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 718251003296 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 718251003297 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 718251003298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251003299 active site 718251003300 phosphorylation site [posttranslational modification] 718251003301 intermolecular recognition site; other site 718251003302 dimerization interface [polypeptide binding]; other site 718251003303 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718251003304 DNA binding site [nucleotide binding] 718251003305 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 718251003306 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718251003307 dimerization interface [polypeptide binding]; other site 718251003308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251003309 dimer interface [polypeptide binding]; other site 718251003310 phosphorylation site [posttranslational modification] 718251003311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251003312 ATP binding site [chemical binding]; other site 718251003313 Mg2+ binding site [ion binding]; other site 718251003314 G-X-G motif; other site 718251003315 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 718251003316 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 718251003317 Protein export membrane protein; Region: SecD_SecF; cl14618 718251003318 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 718251003319 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718251003320 HlyD family secretion protein; Region: HlyD_3; pfam13437 718251003321 hypothetical protein; Provisional; Region: PRK10579 718251003322 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 718251003323 nudix motif; other site 718251003324 recombination associated protein; Reviewed; Region: rdgC; PRK00321 718251003325 fructokinase; Reviewed; Region: PRK09557 718251003326 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 718251003327 nucleotide binding site [chemical binding]; other site 718251003328 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 718251003329 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 718251003330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251003331 AAA domain; Region: AAA_23; pfam13476 718251003332 Walker A/P-loop; other site 718251003333 ATP binding site [chemical binding]; other site 718251003334 Q-loop/lid; other site 718251003335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251003336 ABC transporter signature motif; other site 718251003337 Walker B; other site 718251003338 D-loop; other site 718251003339 H-loop/switch region; other site 718251003340 exonuclease subunit SbcD; Provisional; Region: PRK10966 718251003341 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 718251003342 active site 718251003343 metal binding site [ion binding]; metal-binding site 718251003344 DNA binding site [nucleotide binding] 718251003345 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 718251003346 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 718251003347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251003348 active site 718251003349 phosphorylation site [posttranslational modification] 718251003350 intermolecular recognition site; other site 718251003351 dimerization interface [polypeptide binding]; other site 718251003352 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718251003353 DNA binding site [nucleotide binding] 718251003354 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 718251003355 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 718251003356 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718251003357 putative active site [active] 718251003358 heme pocket [chemical binding]; other site 718251003359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251003360 dimer interface [polypeptide binding]; other site 718251003361 phosphorylation site [posttranslational modification] 718251003362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251003363 ATP binding site [chemical binding]; other site 718251003364 Mg2+ binding site [ion binding]; other site 718251003365 G-X-G motif; other site 718251003366 exopolyphosphatase; Provisional; Region: PRK10854 718251003367 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 718251003368 nucleotide binding site [chemical binding]; other site 718251003369 polyphosphate kinase; Provisional; Region: PRK05443 718251003370 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 718251003371 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 718251003372 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 718251003373 putative active site [active] 718251003374 catalytic site [active] 718251003375 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 718251003376 putative active site [active] 718251003377 catalytic site [active] 718251003378 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 718251003379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718251003380 Coenzyme A binding pocket [chemical binding]; other site 718251003381 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 718251003382 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 718251003383 active site 718251003384 substrate binding site [chemical binding]; other site 718251003385 cosubstrate binding site; other site 718251003386 catalytic site [active] 718251003387 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 718251003388 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 718251003389 dimerization interface [polypeptide binding]; other site 718251003390 putative ATP binding site [chemical binding]; other site 718251003391 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718251003392 active site 718251003393 uracil transporter; Provisional; Region: PRK10720 718251003394 DoxX; Region: DoxX; pfam07681 718251003395 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 718251003396 DNA replication initiation factor; Provisional; Region: PRK08084 718251003397 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 718251003398 ArsC family; Region: ArsC; pfam03960 718251003399 catalytic residues [active] 718251003400 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 718251003401 Peptidase family M48; Region: Peptidase_M48; pfam01435 718251003402 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 718251003403 Domain of unknown function DUF20; Region: UPF0118; pfam01594 718251003404 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 718251003405 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 718251003406 catalytic triad [active] 718251003407 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 718251003408 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 718251003409 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 718251003410 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 718251003411 dihydrodipicolinate synthase; Region: dapA; TIGR00674 718251003412 dimer interface [polypeptide binding]; other site 718251003413 active site 718251003414 catalytic residue [active] 718251003415 lipoprotein; Provisional; Region: PRK11679 718251003416 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 718251003417 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 718251003418 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 718251003419 ATP binding site [chemical binding]; other site 718251003420 active site 718251003421 substrate binding site [chemical binding]; other site 718251003422 Putative cyclase; Region: Cyclase; cl00814 718251003423 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 718251003424 amphipathic channel; other site 718251003425 Asn-Pro-Ala signature motifs; other site 718251003426 hypothetical protein; Provisional; Region: PRK06489 718251003427 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 718251003428 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 718251003429 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 718251003430 Helicase; Region: Helicase_RecD; pfam05127 718251003431 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 718251003432 putative hydrolase; Provisional; Region: PRK11460 718251003433 Predicted esterase [General function prediction only]; Region: COG0400 718251003434 Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980 718251003435 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 718251003436 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 718251003437 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 718251003438 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 718251003439 metal binding site [ion binding]; metal-binding site 718251003440 dimer interface [polypeptide binding]; other site 718251003441 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 718251003442 ArsC family; Region: ArsC; pfam03960 718251003443 putative catalytic residues [active] 718251003444 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 718251003445 Protein export membrane protein; Region: SecD_SecF; cl14618 718251003446 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 718251003447 transcriptional regulator NarP; Provisional; Region: PRK10403 718251003448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251003449 active site 718251003450 phosphorylation site [posttranslational modification] 718251003451 intermolecular recognition site; other site 718251003452 dimerization interface [polypeptide binding]; other site 718251003453 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718251003454 DNA binding residues [nucleotide binding] 718251003455 dimerization interface [polypeptide binding]; other site 718251003456 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 718251003457 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 718251003458 HAMP domain; Region: HAMP; pfam00672 718251003459 dimerization interface [polypeptide binding]; other site 718251003460 Histidine kinase; Region: HisKA_3; pfam07730 718251003461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251003462 ATP binding site [chemical binding]; other site 718251003463 Mg2+ binding site [ion binding]; other site 718251003464 G-X-G motif; other site 718251003465 ferredoxin-type protein; Provisional; Region: PRK10194 718251003466 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 718251003467 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 718251003468 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 718251003469 [4Fe-4S] binding site [ion binding]; other site 718251003470 molybdopterin cofactor binding site; other site 718251003471 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 718251003472 molybdopterin cofactor binding site; other site 718251003473 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 718251003474 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 718251003475 4Fe-4S binding domain; Region: Fer4_5; pfam12801 718251003476 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 718251003477 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 718251003478 cytochrome c-type protein NapC; Provisional; Region: PRK10617 718251003479 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 718251003480 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 718251003481 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 718251003482 dimer interface [polypeptide binding]; other site 718251003483 ADP-ribose binding site [chemical binding]; other site 718251003484 active site 718251003485 nudix motif; other site 718251003486 metal binding site [ion binding]; metal-binding site 718251003487 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 718251003488 Malic enzyme, N-terminal domain; Region: malic; pfam00390 718251003489 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 718251003490 putative NAD(P) binding site [chemical binding]; other site 718251003491 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 718251003492 Protein of unknown function, DUF399; Region: DUF399; pfam04187 718251003493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 718251003494 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 718251003495 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 718251003496 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 718251003497 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 718251003498 active site 718251003499 metal binding site [ion binding]; metal-binding site 718251003500 putative acetyltransferase; Provisional; Region: PRK03624 718251003501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718251003502 Coenzyme A binding pocket [chemical binding]; other site 718251003503 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 718251003504 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 718251003505 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 718251003506 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 718251003507 HPr interaction site; other site 718251003508 glycerol kinase (GK) interaction site [polypeptide binding]; other site 718251003509 active site 718251003510 phosphorylation site [posttranslational modification] 718251003511 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 718251003512 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 718251003513 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 718251003514 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 718251003515 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 718251003516 dimerization domain swap beta strand [polypeptide binding]; other site 718251003517 regulatory protein interface [polypeptide binding]; other site 718251003518 active site 718251003519 regulatory phosphorylation site [posttranslational modification]; other site 718251003520 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 718251003521 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 718251003522 dimer interface [polypeptide binding]; other site 718251003523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251003524 catalytic residue [active] 718251003525 putative sulfate transport protein CysZ; Validated; Region: PRK04949 718251003526 cell division protein ZipA; Provisional; Region: PRK03427 718251003527 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 718251003528 FtsZ protein binding site [polypeptide binding]; other site 718251003529 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 718251003530 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 718251003531 nucleotide binding pocket [chemical binding]; other site 718251003532 K-X-D-G motif; other site 718251003533 catalytic site [active] 718251003534 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 718251003535 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 718251003536 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 718251003537 Dimer interface [polypeptide binding]; other site 718251003538 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 718251003539 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 718251003540 active site 718251003541 HIGH motif; other site 718251003542 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 718251003543 active site 718251003544 KMSKS motif; other site 718251003545 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 718251003546 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 718251003547 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 718251003548 Nucleoside recognition; Region: Gate; pfam07670 718251003549 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 718251003550 manganese transport protein MntH; Reviewed; Region: PRK00701 718251003551 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 718251003552 glucokinase; Provisional; Region: glk; PRK00292 718251003553 glucokinase, proteobacterial type; Region: glk; TIGR00749 718251003554 secY/secA suppressor protein; Provisional; Region: PRK11467 718251003555 DsrE/DsrF-like family; Region: DrsE; cl00672 718251003556 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 718251003557 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 718251003558 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 718251003559 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 718251003560 Ligand binding site; other site 718251003561 DXD motif; other site 718251003562 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 718251003563 aspartate racemase; Region: asp_race; TIGR00035 718251003564 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 718251003565 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 718251003566 ATP binding site [chemical binding]; other site 718251003567 substrate interface [chemical binding]; other site 718251003568 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 718251003569 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 718251003570 dimer interface [polypeptide binding]; other site 718251003571 putative functional site; other site 718251003572 putative MPT binding site; other site 718251003573 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 718251003574 active site 718251003575 hypothetical protein; Provisional; Region: PRK10835 718251003576 Predicted membrane protein [Function unknown]; Region: COG2311 718251003577 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 718251003578 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718251003579 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 718251003580 putative active site [active] 718251003581 malate dehydrogenase; Provisional; Region: PRK13529 718251003582 Malic enzyme, N-terminal domain; Region: malic; pfam00390 718251003583 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 718251003584 NAD(P) binding site [chemical binding]; other site 718251003585 cytidine deaminase; Provisional; Region: PRK09027 718251003586 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 718251003587 active site 718251003588 catalytic motif [active] 718251003589 Zn binding site [ion binding]; other site 718251003590 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 718251003591 active site 718251003592 catalytic motif [active] 718251003593 Zn binding site [ion binding]; other site 718251003594 hypothetical protein; Provisional; Region: PRK10711 718251003595 hypothetical protein; Provisional; Region: PRK01821 718251003596 Predicted permeases [General function prediction only]; Region: RarD; COG2962 718251003597 exonuclease I; Provisional; Region: sbcB; PRK11779 718251003598 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 718251003599 active site 718251003600 catalytic site [active] 718251003601 substrate binding site [chemical binding]; other site 718251003602 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 718251003603 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 718251003604 Integrase core domain; Region: rve_3; pfam13683 718251003605 Predicted membrane protein [Function unknown]; Region: COG1289 718251003606 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 718251003607 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 718251003608 DEAD_2; Region: DEAD_2; pfam06733 718251003609 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 718251003610 LPS O-antigen length regulator; Provisional; Region: PRK10381 718251003611 Chain length determinant protein; Region: Wzz; cl15801 718251003612 endonuclease IV; Provisional; Region: PRK01060 718251003613 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 718251003614 AP (apurinic/apyrimidinic) site pocket; other site 718251003615 DNA interaction; other site 718251003616 Metal-binding active site; metal-binding site 718251003617 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 718251003618 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 718251003619 Ligand Binding Site [chemical binding]; other site 718251003620 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 718251003621 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251003622 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 718251003623 putative dimerization interface [polypeptide binding]; other site 718251003624 lysine transporter; Provisional; Region: PRK10836 718251003625 Peptidase M16C associated; Region: M16C_assoc; pfam08367 718251003626 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 718251003627 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 718251003628 active site 718251003629 HIGH motif; other site 718251003630 KMSKS motif; other site 718251003631 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 718251003632 tRNA binding surface [nucleotide binding]; other site 718251003633 anticodon binding site; other site 718251003634 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 718251003635 dimer interface [polypeptide binding]; other site 718251003636 putative tRNA-binding site [nucleotide binding]; other site 718251003637 antiporter inner membrane protein; Provisional; Region: PRK11670 718251003638 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 718251003639 Walker A motif; other site 718251003640 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 718251003641 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 718251003642 ATP-binding site [chemical binding]; other site 718251003643 Sugar specificity; other site 718251003644 Pyrimidine base specificity; other site 718251003645 EamA-like transporter family; Region: EamA; pfam00892 718251003646 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 718251003647 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 718251003648 trimer interface [polypeptide binding]; other site 718251003649 active site 718251003650 putative assembly protein; Provisional; Region: PRK10833 718251003651 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 718251003652 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 718251003653 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 718251003654 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 718251003655 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 718251003656 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 718251003657 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 718251003658 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 718251003659 active site 718251003660 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 718251003661 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718251003662 putative ADP-binding pocket [chemical binding]; other site 718251003663 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718251003664 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 718251003665 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718251003666 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 718251003667 putative ADP-binding pocket [chemical binding]; other site 718251003668 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 718251003669 active site 718251003670 tetramer interface; other site 718251003671 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 718251003672 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 718251003673 NAD binding site [chemical binding]; other site 718251003674 homodimer interface [polypeptide binding]; other site 718251003675 active site 718251003676 substrate binding site [chemical binding]; other site 718251003677 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 718251003678 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 718251003679 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 718251003680 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 718251003681 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 718251003682 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 718251003683 putative NAD(P) binding site [chemical binding]; other site 718251003684 active site 718251003685 putative substrate binding site [chemical binding]; other site 718251003686 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 718251003687 NeuB family; Region: NeuB; pfam03102 718251003688 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 718251003689 NeuB binding interface [polypeptide binding]; other site 718251003690 putative substrate binding site [chemical binding]; other site 718251003691 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 718251003692 ligand binding site; other site 718251003693 tetramer interface; other site 718251003694 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 718251003695 active site 718251003696 catalytic triad [active] 718251003697 oxyanion hole [active] 718251003698 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 718251003699 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 718251003700 active site 718251003701 homodimer interface [polypeptide binding]; other site 718251003702 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 718251003703 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 718251003704 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 718251003705 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 718251003706 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 718251003707 hypothetical protein; Provisional; Region: PRK05423 718251003708 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 718251003709 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 718251003710 putative metal dependent hydrolase; Provisional; Region: PRK11598 718251003711 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 718251003712 Sulfatase; Region: Sulfatase; pfam00884 718251003713 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 718251003714 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 718251003715 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 718251003716 FHIPEP family; Region: FHIPEP; pfam00771 718251003717 Flagellar protein FlhE; Region: FlhE; pfam06366 718251003718 FlgN protein; Region: FlgN; cl09176 718251003719 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 718251003720 SAF-like; Region: SAF_2; pfam13144 718251003721 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 718251003722 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 718251003723 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 718251003724 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 718251003725 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 718251003726 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 718251003727 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 718251003728 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 718251003729 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 718251003730 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 718251003731 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 718251003732 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 718251003733 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 718251003734 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 718251003735 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 718251003736 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 718251003737 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 718251003738 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 718251003739 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 718251003740 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 718251003741 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 718251003742 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 718251003743 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 718251003744 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 718251003745 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 718251003746 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 718251003747 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 718251003748 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 718251003749 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 718251003750 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 718251003751 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 718251003752 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 718251003753 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718251003754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251003755 homodimer interface [polypeptide binding]; other site 718251003756 catalytic residue [active] 718251003757 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 718251003758 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 718251003759 trimer interface [polypeptide binding]; other site 718251003760 eyelet of channel; other site 718251003761 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 718251003762 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 718251003763 putative dimer interface [polypeptide binding]; other site 718251003764 putative anticodon binding site; other site 718251003765 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 718251003766 homodimer interface [polypeptide binding]; other site 718251003767 motif 1; other site 718251003768 motif 2; other site 718251003769 active site 718251003770 motif 3; other site 718251003771 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 718251003772 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 718251003773 active site 718251003774 aminopeptidase N; Provisional; Region: pepN; PRK14015 718251003775 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 718251003776 active site 718251003777 Zn binding site [ion binding]; other site 718251003778 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718251003779 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251003780 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718251003781 dimerization interface [polypeptide binding]; other site 718251003782 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 718251003783 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 718251003784 dimer interface [polypeptide binding]; other site 718251003785 Citrate transporter; Region: CitMHS; pfam03600 718251003786 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 718251003787 transketolase; Reviewed; Region: PRK05899 718251003788 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 718251003789 TPP-binding site [chemical binding]; other site 718251003790 dimer interface [polypeptide binding]; other site 718251003791 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 718251003792 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 718251003793 PYR/PP interface [polypeptide binding]; other site 718251003794 dimer interface [polypeptide binding]; other site 718251003795 TPP binding site [chemical binding]; other site 718251003796 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 718251003797 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 718251003798 active site 718251003799 catalytic residues [active] 718251003800 metal binding site [ion binding]; metal-binding site 718251003801 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 718251003802 CoA-transferase family III; Region: CoA_transf_3; pfam02515 718251003803 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 718251003804 catalytic site [active] 718251003805 BNR repeat-like domain; Region: BNR_2; pfam13088 718251003806 Asp-box motif; other site 718251003807 Autotransporter beta-domain; Region: Autotransporter; smart00869 718251003808 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 718251003809 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 718251003810 quinone interaction residues [chemical binding]; other site 718251003811 active site 718251003812 catalytic residues [active] 718251003813 FMN binding site [chemical binding]; other site 718251003814 substrate binding site [chemical binding]; other site 718251003815 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 718251003816 PapC N-terminal domain; Region: PapC_N; pfam13954 718251003817 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 718251003818 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 718251003819 PapC C-terminal domain; Region: PapC_C; pfam13953 718251003820 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 718251003821 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 718251003822 Ion channel; Region: Ion_trans_2; pfam07885 718251003823 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 718251003824 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 718251003825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 718251003826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251003827 S-adenosylmethionine binding site [chemical binding]; other site 718251003828 ABC transporter ATPase component; Reviewed; Region: PRK11147 718251003829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251003830 Walker A/P-loop; other site 718251003831 ATP binding site [chemical binding]; other site 718251003832 Q-loop/lid; other site 718251003833 ABC transporter signature motif; other site 718251003834 Walker B; other site 718251003835 D-loop; other site 718251003836 H-loop/switch region; other site 718251003837 ABC transporter; Region: ABC_tran_2; pfam12848 718251003838 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718251003839 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 718251003840 Paraquat-inducible protein A; Region: PqiA; pfam04403 718251003841 Paraquat-inducible protein A; Region: PqiA; pfam04403 718251003842 paraquat-inducible protein B; Provisional; Region: PRK10807 718251003843 mce related protein; Region: MCE; pfam02470 718251003844 mce related protein; Region: MCE; pfam02470 718251003845 mce related protein; Region: MCE; pfam02470 718251003846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 718251003847 Protein of unknown function (DUF330); Region: DUF330; pfam03886 718251003848 ribosome modulation factor; Provisional; Region: PRK14563 718251003849 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 718251003850 active site 1 [active] 718251003851 dimer interface [polypeptide binding]; other site 718251003852 active site 2 [active] 718251003853 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 718251003854 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 718251003855 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 718251003856 outer membrane protein A; Reviewed; Region: PRK10808 718251003857 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 718251003858 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 718251003859 ligand binding site [chemical binding]; other site 718251003860 SOS cell division inhibitor; Provisional; Region: PRK10595 718251003861 TfoX N-terminal domain; Region: TfoX_N; pfam04993 718251003862 TfoX C-terminal domain; Region: TfoX_C; pfam04994 718251003863 TIGR01666 family membrane protein; Region: YCCS 718251003864 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 718251003865 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 718251003866 Predicted membrane protein [Function unknown]; Region: COG3304 718251003867 Domain of unknown function (DUF307); Region: DUF307; pfam03733 718251003868 Domain of unknown function (DUF307); Region: DUF307; pfam03733 718251003869 DNA helicase IV; Provisional; Region: helD; PRK11054 718251003870 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 718251003871 Part of AAA domain; Region: AAA_19; pfam13245 718251003872 Family description; Region: UvrD_C_2; pfam13538 718251003873 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 718251003874 active site 718251003875 dimer interfaces [polypeptide binding]; other site 718251003876 catalytic residues [active] 718251003877 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 718251003878 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 718251003879 heat shock protein HspQ; Provisional; Region: PRK14129 718251003880 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 718251003881 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 718251003882 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 718251003883 putative RNA binding site [nucleotide binding]; other site 718251003884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251003885 S-adenosylmethionine binding site [chemical binding]; other site 718251003886 acylphosphatase; Provisional; Region: PRK14426 718251003887 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 718251003888 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 718251003889 HflBKC-binding inner membrane protein; Provisional; Region: PRK10447 718251003890 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 718251003891 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 718251003892 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 718251003893 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 718251003894 active site 718251003895 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 718251003896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251003897 putative substrate translocation pore; other site 718251003898 palmytilated EEV membrane glycoprotein; Provisional; Region: PHA03003 718251003899 Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106 718251003900 putative active site [active] 718251003901 putative catalytic site [active] 718251003902 Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107 718251003903 putative active site [active] 718251003904 putative catalytic site [active] 718251003905 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 718251003906 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 718251003907 inhibitor-cofactor binding pocket; inhibition site 718251003908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251003909 catalytic residue [active] 718251003910 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 718251003911 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 718251003912 Ligand binding site; other site 718251003913 Putative Catalytic site; other site 718251003914 DXD motif; other site 718251003915 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 718251003916 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 718251003917 active site 718251003918 substrate binding site [chemical binding]; other site 718251003919 cosubstrate binding site; other site 718251003920 catalytic site [active] 718251003921 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 718251003922 active site 718251003923 hexamer interface [polypeptide binding]; other site 718251003924 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 718251003925 NAD binding site [chemical binding]; other site 718251003926 substrate binding site [chemical binding]; other site 718251003927 active site 718251003928 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 718251003929 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 718251003930 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 718251003931 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 718251003932 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 718251003933 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 718251003934 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 718251003935 trimer interface [polypeptide binding]; other site 718251003936 active site 718251003937 substrate binding site [chemical binding]; other site 718251003938 CoA binding site [chemical binding]; other site 718251003939 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 718251003940 DNA-binding site [nucleotide binding]; DNA binding site 718251003941 RNA-binding motif; other site 718251003942 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 718251003943 DNA-binding site [nucleotide binding]; DNA binding site 718251003944 RNA-binding motif; other site 718251003945 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 718251003946 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 718251003947 Domain of unknown function (DUF333); Region: DUF333; pfam03891 718251003948 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 718251003949 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 718251003950 catalytic core [active] 718251003951 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 718251003952 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 718251003953 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 718251003954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251003955 active site 718251003956 phosphorylation site [posttranslational modification] 718251003957 intermolecular recognition site; other site 718251003958 dimerization interface [polypeptide binding]; other site 718251003959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251003960 Walker A motif; other site 718251003961 ATP binding site [chemical binding]; other site 718251003962 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 718251003963 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 718251003964 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718251003965 dimerization interface [polypeptide binding]; other site 718251003966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251003967 dimer interface [polypeptide binding]; other site 718251003968 phosphorylation site [posttranslational modification] 718251003969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251003970 ATP binding site [chemical binding]; other site 718251003971 Mg2+ binding site [ion binding]; other site 718251003972 G-X-G motif; other site 718251003973 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 718251003974 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 718251003975 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 718251003976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251003977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251003978 Isochorismatase family; Region: Isochorismatase; pfam00857 718251003979 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 718251003980 catalytic triad [active] 718251003981 conserved cis-peptide bond; other site 718251003982 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 718251003983 Sulfatase; Region: Sulfatase; pfam00884 718251003984 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 718251003985 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 718251003986 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 718251003987 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 718251003988 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 718251003989 Walker A/P-loop; other site 718251003990 ATP binding site [chemical binding]; other site 718251003991 Q-loop/lid; other site 718251003992 ABC transporter signature motif; other site 718251003993 Walker B; other site 718251003994 D-loop; other site 718251003995 H-loop/switch region; other site 718251003996 TOBE domain; Region: TOBE_2; pfam08402 718251003997 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 718251003998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251003999 dimer interface [polypeptide binding]; other site 718251004000 conserved gate region; other site 718251004001 putative PBP binding loops; other site 718251004002 ABC-ATPase subunit interface; other site 718251004003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251004004 dimer interface [polypeptide binding]; other site 718251004005 conserved gate region; other site 718251004006 putative PBP binding loops; other site 718251004007 ABC-ATPase subunit interface; other site 718251004008 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 718251004009 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 718251004010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251004011 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 718251004012 putative substrate translocation pore; other site 718251004013 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 718251004014 MASE1; Region: MASE1; pfam05231 718251004015 Histidine kinase; Region: HisKA_3; pfam07730 718251004016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251004017 ATP binding site [chemical binding]; other site 718251004018 Mg2+ binding site [ion binding]; other site 718251004019 G-X-G motif; other site 718251004020 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 718251004021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251004022 active site 718251004023 phosphorylation site [posttranslational modification] 718251004024 intermolecular recognition site; other site 718251004025 dimerization interface [polypeptide binding]; other site 718251004026 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718251004027 DNA binding residues [nucleotide binding] 718251004028 dimerization interface [polypeptide binding]; other site 718251004029 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 718251004030 Ligand Binding Site [chemical binding]; other site 718251004031 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 718251004032 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 718251004033 dimer interface [polypeptide binding]; other site 718251004034 active site 718251004035 metal binding site [ion binding]; metal-binding site 718251004036 transcriptional activator FlhD; Provisional; Region: PRK02909 718251004037 transcriptional activator FlhC; Provisional; Region: PRK12722 718251004038 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 718251004039 flagellar motor protein MotA; Validated; Region: PRK09110 718251004040 flagellar motor protein MotB; Validated; Region: motB; PRK09041 718251004041 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 718251004042 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 718251004043 ligand binding site [chemical binding]; other site 718251004044 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 718251004045 putative binding surface; other site 718251004046 active site 718251004047 CheY binding; Region: CheY-binding; pfam09078 718251004048 chemotaxis protein CheA; Provisional; Region: PRK10547 718251004049 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 718251004050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251004051 ATP binding site [chemical binding]; other site 718251004052 Mg2+ binding site [ion binding]; other site 718251004053 G-X-G motif; other site 718251004054 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 718251004055 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 718251004056 putative CheA interaction surface; other site 718251004057 methyl-accepting protein IV; Provisional; Region: PRK09793 718251004058 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 718251004059 dimer interface [polypeptide binding]; other site 718251004060 ligand binding site [chemical binding]; other site 718251004061 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718251004062 dimerization interface [polypeptide binding]; other site 718251004063 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718251004064 dimer interface [polypeptide binding]; other site 718251004065 putative CheW interface [polypeptide binding]; other site 718251004066 methyl-accepting protein IV; Provisional; Region: PRK09793 718251004067 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 718251004068 dimer interface [polypeptide binding]; other site 718251004069 ligand binding site [chemical binding]; other site 718251004070 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718251004071 dimerization interface [polypeptide binding]; other site 718251004072 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718251004073 dimer interface [polypeptide binding]; other site 718251004074 putative CheW interface [polypeptide binding]; other site 718251004075 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 718251004076 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 718251004077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251004078 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 718251004079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251004080 active site 718251004081 phosphorylation site [posttranslational modification] 718251004082 intermolecular recognition site; other site 718251004083 dimerization interface [polypeptide binding]; other site 718251004084 CheB methylesterase; Region: CheB_methylest; pfam01339 718251004085 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 718251004086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251004087 active site 718251004088 phosphorylation site [posttranslational modification] 718251004089 intermolecular recognition site; other site 718251004090 dimerization interface [polypeptide binding]; other site 718251004091 chemotaxis regulator CheZ; Provisional; Region: PRK11166 718251004092 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 718251004093 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 718251004094 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 718251004095 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 718251004096 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 718251004097 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 718251004098 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 718251004099 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 718251004100 putative metal binding site [ion binding]; other site 718251004101 dimer interface [polypeptide binding]; other site 718251004102 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 718251004103 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 718251004104 putative substrate binding pocket [chemical binding]; other site 718251004105 putative dimerization interface [polypeptide binding]; other site 718251004106 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 718251004107 active site 718251004108 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 718251004109 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 718251004110 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 718251004111 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 718251004112 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 718251004113 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 718251004114 isoaspartyl dipeptidase; Provisional; Region: PRK10657 718251004115 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 718251004116 active site 718251004117 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718251004118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251004119 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 718251004120 dimerization interface [polypeptide binding]; other site 718251004121 Uncharacterized conserved protein [Function unknown]; Region: COG0398 718251004122 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 718251004123 mercuric reductase; Validated; Region: PRK06370 718251004124 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 718251004125 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718251004126 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 718251004127 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 718251004128 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 718251004129 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 718251004130 tetramer interface [polypeptide binding]; other site 718251004131 heme binding pocket [chemical binding]; other site 718251004132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 718251004133 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 718251004134 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 718251004135 ATP binding site [chemical binding]; other site 718251004136 Mg++ binding site [ion binding]; other site 718251004137 motif III; other site 718251004138 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718251004139 nucleotide binding region [chemical binding]; other site 718251004140 ATP-binding site [chemical binding]; other site 718251004141 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 718251004142 putative RNA binding site [nucleotide binding]; other site 718251004143 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 718251004144 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718251004145 Coenzyme A binding pocket [chemical binding]; other site 718251004146 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 718251004147 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718251004148 Walker A/P-loop; other site 718251004149 ATP binding site [chemical binding]; other site 718251004150 Q-loop/lid; other site 718251004151 ABC transporter signature motif; other site 718251004152 Walker B; other site 718251004153 D-loop; other site 718251004154 H-loop/switch region; other site 718251004155 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 718251004156 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718251004157 Walker A/P-loop; other site 718251004158 ATP binding site [chemical binding]; other site 718251004159 Q-loop/lid; other site 718251004160 ABC transporter signature motif; other site 718251004161 Walker B; other site 718251004162 D-loop; other site 718251004163 H-loop/switch region; other site 718251004164 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 718251004165 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 718251004166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251004167 dimer interface [polypeptide binding]; other site 718251004168 conserved gate region; other site 718251004169 putative PBP binding loops; other site 718251004170 ABC-ATPase subunit interface; other site 718251004171 nickel transporter permease NikB; Provisional; Region: PRK10352 718251004172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251004173 dimer interface [polypeptide binding]; other site 718251004174 conserved gate region; other site 718251004175 putative PBP binding loops; other site 718251004176 ABC-ATPase subunit interface; other site 718251004177 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 718251004178 substrate binding site [chemical binding]; other site 718251004179 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 718251004180 transcriptional regulator NanR; Provisional; Region: PRK03837 718251004181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718251004182 DNA-binding site [nucleotide binding]; DNA binding site 718251004183 FCD domain; Region: FCD; pfam07729 718251004184 N-acetylneuraminate lyase; Provisional; Region: PRK04147 718251004185 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 718251004186 inhibitor site; inhibition site 718251004187 active site 718251004188 dimer interface [polypeptide binding]; other site 718251004189 catalytic residue [active] 718251004190 putative sialic acid transporter; Provisional; Region: PRK03893 718251004191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251004192 putative substrate translocation pore; other site 718251004193 N-acetylmannosamine kinase; Provisional; Region: PRK05082 718251004194 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 718251004195 nucleotide binding site [chemical binding]; other site 718251004196 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 718251004197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 718251004198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718251004199 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 718251004200 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 718251004201 Transposase; Region: HTH_Tnp_1; pfam01527 718251004202 Integrase core domain; Region: rve; pfam00665 718251004203 Integrase core domain; Region: rve_3; pfam13683 718251004204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251004205 ABC transporter signature motif; other site 718251004206 Walker B; other site 718251004207 D-loop; other site 718251004208 H-loop/switch region; other site 718251004209 integrase; Provisional; Region: PRK09692 718251004210 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 718251004211 active site 718251004212 Int/Topo IB signature motif; other site 718251004213 GTP-binding protein YchF; Reviewed; Region: PRK09601 718251004214 YchF GTPase; Region: YchF; cd01900 718251004215 G1 box; other site 718251004216 GTP/Mg2+ binding site [chemical binding]; other site 718251004217 Switch I region; other site 718251004218 G2 box; other site 718251004219 Switch II region; other site 718251004220 G3 box; other site 718251004221 G4 box; other site 718251004222 G5 box; other site 718251004223 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 718251004224 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 718251004225 putative active site [active] 718251004226 catalytic residue [active] 718251004227 hypothetical protein; Provisional; Region: PRK10692 718251004228 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 718251004229 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 718251004230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718251004231 active site 718251004232 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 718251004233 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 718251004234 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 718251004235 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 718251004236 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 718251004237 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 718251004238 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 718251004239 tRNA; other site 718251004240 putative tRNA binding site [nucleotide binding]; other site 718251004241 putative NADP binding site [chemical binding]; other site 718251004242 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 718251004243 peptide chain release factor 1; Validated; Region: prfA; PRK00591 718251004244 This domain is found in peptide chain release factors; Region: PCRF; smart00937 718251004245 RF-1 domain; Region: RF-1; pfam00472 718251004246 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 718251004247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251004248 hypothetical protein; Provisional; Region: PRK10941 718251004249 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 718251004250 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 718251004251 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 718251004252 putative transporter; Provisional; Region: PRK11660 718251004253 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 718251004254 Sulfate transporter family; Region: Sulfate_transp; pfam00916 718251004255 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 718251004256 hypothetical protein; Provisional; Region: PRK02487 718251004257 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 718251004258 hypothetical protein; Provisional; Region: PRK11622 718251004259 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 718251004260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251004261 POT family; Region: PTR2; cl17359 718251004262 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 718251004263 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 718251004264 putative ligand binding site [chemical binding]; other site 718251004265 NAD binding site [chemical binding]; other site 718251004266 dimerization interface [polypeptide binding]; other site 718251004267 catalytic site [active] 718251004268 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 718251004269 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718251004270 metal binding site [ion binding]; metal-binding site 718251004271 active site 718251004272 I-site; other site 718251004273 putative hydrolase; Validated; Region: PRK09248 718251004274 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 718251004275 active site 718251004276 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 718251004277 lipoprotein; Provisional; Region: PRK10598 718251004278 multidrug resistance protein MdtH; Provisional; Region: PRK11646 718251004279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251004280 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 718251004281 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 718251004282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 718251004283 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 718251004284 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 718251004285 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 718251004286 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 718251004287 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 718251004288 active site 718251004289 HIGH motif; other site 718251004290 KMSK motif region; other site 718251004291 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 718251004292 tRNA binding surface [nucleotide binding]; other site 718251004293 anticodon binding site; other site 718251004294 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 718251004295 putative metal binding site [ion binding]; other site 718251004296 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 718251004297 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718251004298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251004299 homodimer interface [polypeptide binding]; other site 718251004300 catalytic residue [active] 718251004301 copper homeostasis protein CutC; Provisional; Region: PRK11572 718251004302 Methyltransferase domain; Region: Methyltransf_23; pfam13489 718251004303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251004304 S-adenosylmethionine binding site [chemical binding]; other site 718251004305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251004306 S-adenosylmethionine binding site [chemical binding]; other site 718251004307 phenylalanine transporter; Provisional; Region: PRK10249 718251004308 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 718251004309 hypothetical protein; Provisional; Region: PRK10302 718251004310 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 718251004311 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 718251004312 dimer interface [polypeptide binding]; other site 718251004313 anticodon binding site; other site 718251004314 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 718251004315 homodimer interface [polypeptide binding]; other site 718251004316 motif 1; other site 718251004317 active site 718251004318 motif 2; other site 718251004319 GAD domain; Region: GAD; pfam02938 718251004320 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 718251004321 active site 718251004322 motif 3; other site 718251004323 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 718251004324 nudix motif; other site 718251004325 hypothetical protein; Validated; Region: PRK00110 718251004326 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 718251004327 active site 718251004328 putative DNA-binding cleft [nucleotide binding]; other site 718251004329 dimer interface [polypeptide binding]; other site 718251004330 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 718251004331 RuvA N terminal domain; Region: RuvA_N; pfam01330 718251004332 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 718251004333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251004334 Walker A motif; other site 718251004335 ATP binding site [chemical binding]; other site 718251004336 Walker B motif; other site 718251004337 arginine finger; other site 718251004338 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 718251004339 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718251004340 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 718251004341 ABC-ATPase subunit interface; other site 718251004342 dimer interface [polypeptide binding]; other site 718251004343 putative PBP binding regions; other site 718251004344 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 718251004345 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 718251004346 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 718251004347 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 718251004348 metal binding site [ion binding]; metal-binding site 718251004349 putative peptidase; Provisional; Region: PRK11649 718251004350 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 718251004351 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 718251004352 Peptidase family M23; Region: Peptidase_M23; pfam01551 718251004353 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 718251004354 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 718251004355 putative acyl-acceptor binding pocket; other site 718251004356 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 718251004357 pyruvate kinase; Provisional; Region: PRK05826 718251004358 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 718251004359 domain interfaces; other site 718251004360 active site 718251004361 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 718251004362 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 718251004363 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 718251004364 putative active site [active] 718251004365 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 718251004366 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 718251004367 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 718251004368 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 718251004369 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 718251004370 putative active site [active] 718251004371 phosphogluconate dehydratase; Validated; Region: PRK09054 718251004372 6-phosphogluconate dehydratase; Region: edd; TIGR01196 718251004373 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 718251004374 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 718251004375 active site 718251004376 intersubunit interface [polypeptide binding]; other site 718251004377 catalytic residue [active] 718251004378 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 718251004379 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 718251004380 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 718251004381 homotrimer interaction site [polypeptide binding]; other site 718251004382 putative active site [active] 718251004383 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 718251004384 DEAD/DEAH box helicase; Region: DEAD; pfam00270 718251004385 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 718251004386 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 718251004387 Glycoprotease family; Region: Peptidase_M22; pfam00814 718251004388 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 718251004389 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 718251004390 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 718251004391 acyl-activating enzyme (AAE) consensus motif; other site 718251004392 putative AMP binding site [chemical binding]; other site 718251004393 putative active site [active] 718251004394 putative CoA binding site [chemical binding]; other site 718251004395 ribonuclease D; Provisional; Region: PRK10829 718251004396 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 718251004397 catalytic site [active] 718251004398 putative active site [active] 718251004399 putative substrate binding site [chemical binding]; other site 718251004400 HRDC domain; Region: HRDC; pfam00570 718251004401 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 718251004402 cell division inhibitor MinD; Provisional; Region: PRK10818 718251004403 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 718251004404 Switch I; other site 718251004405 Switch II; other site 718251004406 septum formation inhibitor; Reviewed; Region: minC; PRK03511 718251004407 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 718251004408 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 718251004409 YcgL domain; Region: YcgL; cl01189 718251004410 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 718251004411 hypothetical protein; Provisional; Region: PRK10691 718251004412 hypothetical protein; Provisional; Region: PRK05170 718251004413 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 718251004414 Ligand Binding Site [chemical binding]; other site 718251004415 disulfide bond formation protein B; Provisional; Region: PRK01749 718251004416 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 718251004417 fatty acid metabolism regulator; Provisional; Region: PRK04984 718251004418 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718251004419 DNA-binding site [nucleotide binding]; DNA binding site 718251004420 FadR C-terminal domain; Region: FadR_C; pfam07840 718251004421 SpoVR family protein; Provisional; Region: PRK11767 718251004422 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 718251004423 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 718251004424 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718251004425 hydroxyglutarate oxidase; Provisional; Region: PRK11728 718251004426 hypothetical protein; Provisional; Region: PRK10174 718251004427 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 718251004428 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 718251004429 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 718251004430 hypothetical protein; Provisional; Region: PRK05325 718251004431 PrkA family serine protein kinase; Provisional; Region: PRK15455 718251004432 AAA ATPase domain; Region: AAA_16; pfam13191 718251004433 Walker A motif; other site 718251004434 ATP binding site [chemical binding]; other site 718251004435 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 718251004436 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 718251004437 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 718251004438 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718251004439 N-terminal plug; other site 718251004440 ligand-binding site [chemical binding]; other site 718251004441 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 718251004442 active site 718251004443 phosphate binding residues; other site 718251004444 catalytic residues [active] 718251004445 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 718251004446 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 718251004447 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 718251004448 methionine sulfoxide reductase B; Provisional; Region: PRK00222 718251004449 SelR domain; Region: SelR; pfam01641 718251004450 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 718251004451 Isochorismatase family; Region: Isochorismatase; pfam00857 718251004452 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 718251004453 catalytic triad [active] 718251004454 metal binding site [ion binding]; metal-binding site 718251004455 conserved cis-peptide bond; other site 718251004456 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 718251004457 active site 718251004458 homodimer interface [polypeptide binding]; other site 718251004459 protease 4; Provisional; Region: PRK10949 718251004460 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 718251004461 oligomer interface [polypeptide binding]; other site 718251004462 tandem repeat interface [polypeptide binding]; other site 718251004463 active site residues [active] 718251004464 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 718251004465 tandem repeat interface [polypeptide binding]; other site 718251004466 oligomer interface [polypeptide binding]; other site 718251004467 active site residues [active] 718251004468 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 718251004469 putative FMN binding site [chemical binding]; other site 718251004470 selenophosphate synthetase; Provisional; Region: PRK00943 718251004471 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 718251004472 dimerization interface [polypeptide binding]; other site 718251004473 putative ATP binding site [chemical binding]; other site 718251004474 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 718251004475 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 718251004476 active site residue [active] 718251004477 DNA topoisomerase III; Provisional; Region: PRK07726 718251004478 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 718251004479 active site 718251004480 putative interdomain interaction site [polypeptide binding]; other site 718251004481 putative metal-binding site [ion binding]; other site 718251004482 putative nucleotide binding site [chemical binding]; other site 718251004483 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 718251004484 domain I; other site 718251004485 DNA binding groove [nucleotide binding] 718251004486 phosphate binding site [ion binding]; other site 718251004487 domain II; other site 718251004488 domain III; other site 718251004489 nucleotide binding site [chemical binding]; other site 718251004490 catalytic site [active] 718251004491 domain IV; other site 718251004492 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 718251004493 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 718251004494 active site 718251004495 8-oxo-dGMP binding site [chemical binding]; other site 718251004496 nudix motif; other site 718251004497 metal binding site [ion binding]; metal-binding site 718251004498 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 718251004499 putative catalytic site [active] 718251004500 putative phosphate binding site [ion binding]; other site 718251004501 active site 718251004502 metal binding site A [ion binding]; metal-binding site 718251004503 DNA binding site [nucleotide binding] 718251004504 putative AP binding site [nucleotide binding]; other site 718251004505 putative metal binding site B [ion binding]; other site 718251004506 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 718251004507 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 718251004508 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 718251004509 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 718251004510 putative active site [active] 718251004511 putative substrate binding site [chemical binding]; other site 718251004512 putative cosubstrate binding site; other site 718251004513 catalytic site [active] 718251004514 hypothetical protein; Provisional; Region: PRK01617 718251004515 SEC-C motif; Region: SEC-C; pfam02810 718251004516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251004517 active site 718251004518 response regulator of RpoS; Provisional; Region: PRK10693 718251004519 phosphorylation site [posttranslational modification] 718251004520 intermolecular recognition site; other site 718251004521 dimerization interface [polypeptide binding]; other site 718251004522 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 718251004523 active site 718251004524 tetramer interface; other site 718251004525 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 718251004526 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 718251004527 thymidine kinase; Provisional; Region: PRK04296 718251004528 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 718251004529 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 718251004530 putative catalytic cysteine [active] 718251004531 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 718251004532 putative active site [active] 718251004533 metal binding site [ion binding]; metal-binding site 718251004534 hypothetical protein; Provisional; Region: PRK11111 718251004535 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 718251004536 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 718251004537 peptide binding site [polypeptide binding]; other site 718251004538 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 718251004539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251004540 dimer interface [polypeptide binding]; other site 718251004541 conserved gate region; other site 718251004542 putative PBP binding loops; other site 718251004543 ABC-ATPase subunit interface; other site 718251004544 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 718251004545 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 718251004546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251004547 dimer interface [polypeptide binding]; other site 718251004548 conserved gate region; other site 718251004549 ABC-ATPase subunit interface; other site 718251004550 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 718251004551 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718251004552 Walker A/P-loop; other site 718251004553 ATP binding site [chemical binding]; other site 718251004554 Q-loop/lid; other site 718251004555 ABC transporter signature motif; other site 718251004556 Walker B; other site 718251004557 D-loop; other site 718251004558 H-loop/switch region; other site 718251004559 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 718251004560 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 718251004561 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718251004562 Walker A/P-loop; other site 718251004563 ATP binding site [chemical binding]; other site 718251004564 Q-loop/lid; other site 718251004565 ABC transporter signature motif; other site 718251004566 Walker B; other site 718251004567 D-loop; other site 718251004568 H-loop/switch region; other site 718251004569 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 718251004570 dsDNA-mimic protein; Reviewed; Region: PRK05094 718251004571 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 718251004572 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 718251004573 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 718251004574 putative active site [active] 718251004575 catalytic site [active] 718251004576 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 718251004577 putative active site [active] 718251004578 catalytic site [active] 718251004579 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 718251004580 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 718251004581 dimerization interface [polypeptide binding]; other site 718251004582 DPS ferroxidase diiron center [ion binding]; other site 718251004583 ion pore; other site 718251004584 YciI-like protein; Reviewed; Region: PRK11370 718251004585 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 718251004586 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 718251004587 intracellular septation protein A; Reviewed; Region: PRK00259 718251004588 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 718251004589 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 718251004590 Sulfate transporter family; Region: Sulfate_transp; pfam00916 718251004591 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 718251004592 Domain of unknown function (DUF1919); Region: DUF1919; cl01628 718251004593 hypothetical protein; Provisional; Region: PRK02868 718251004594 outer membrane protein W; Provisional; Region: PRK10959 718251004595 BON domain; Region: BON; pfam04972 718251004596 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 718251004597 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 718251004598 substrate binding site [chemical binding]; other site 718251004599 active site 718251004600 catalytic residues [active] 718251004601 heterodimer interface [polypeptide binding]; other site 718251004602 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 718251004603 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 718251004604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251004605 catalytic residue [active] 718251004606 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 718251004607 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 718251004608 active site 718251004609 ribulose/triose binding site [chemical binding]; other site 718251004610 phosphate binding site [ion binding]; other site 718251004611 substrate (anthranilate) binding pocket [chemical binding]; other site 718251004612 product (indole) binding pocket [chemical binding]; other site 718251004613 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 718251004614 active site 718251004615 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 718251004616 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 718251004617 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 718251004618 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 718251004619 Glutamine amidotransferase class-I; Region: GATase; pfam00117 718251004620 glutamine binding [chemical binding]; other site 718251004621 catalytic triad [active] 718251004622 anthranilate synthase component I; Provisional; Region: PRK13564 718251004623 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 718251004624 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 718251004625 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 718251004626 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 718251004627 active site 718251004628 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 718251004629 hypothetical protein; Provisional; Region: PRK11630 718251004630 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 718251004631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251004632 dimer interface [polypeptide binding]; other site 718251004633 conserved gate region; other site 718251004634 putative PBP binding loops; other site 718251004635 ABC-ATPase subunit interface; other site 718251004636 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 718251004637 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718251004638 substrate binding pocket [chemical binding]; other site 718251004639 membrane-bound complex binding site; other site 718251004640 hinge residues; other site 718251004641 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 718251004642 transmembrane helices; other site 718251004643 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 718251004644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718251004645 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 718251004646 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 718251004647 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718251004648 RNA binding surface [nucleotide binding]; other site 718251004649 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 718251004650 probable active site [active] 718251004651 cobalamin synthase; Reviewed; Region: cobS; PRK00235 718251004652 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 718251004653 catalytic core [active] 718251004654 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 718251004655 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 718251004656 Walker A motif; other site 718251004657 homodimer interface [polypeptide binding]; other site 718251004658 ATP binding site [chemical binding]; other site 718251004659 hydroxycobalamin binding site [chemical binding]; other site 718251004660 Walker B motif; other site 718251004661 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 718251004662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718251004663 NAD(P) binding site [chemical binding]; other site 718251004664 active site 718251004665 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 718251004666 putative inner membrane peptidase; Provisional; Region: PRK11778 718251004667 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 718251004668 tandem repeat interface [polypeptide binding]; other site 718251004669 oligomer interface [polypeptide binding]; other site 718251004670 active site residues [active] 718251004671 hypothetical protein; Provisional; Region: PRK11037 718251004672 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 718251004673 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 718251004674 active site 718251004675 interdomain interaction site; other site 718251004676 putative metal-binding site [ion binding]; other site 718251004677 nucleotide binding site [chemical binding]; other site 718251004678 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 718251004679 domain I; other site 718251004680 DNA binding groove [nucleotide binding] 718251004681 phosphate binding site [ion binding]; other site 718251004682 domain II; other site 718251004683 domain III; other site 718251004684 nucleotide binding site [chemical binding]; other site 718251004685 catalytic site [active] 718251004686 domain IV; other site 718251004687 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 718251004688 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 718251004689 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 718251004690 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 718251004691 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251004692 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 718251004693 substrate binding site [chemical binding]; other site 718251004694 dimerization interface [polypeptide binding]; other site 718251004695 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 718251004696 DNA-binding site [nucleotide binding]; DNA binding site 718251004697 RNA-binding motif; other site 718251004698 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 718251004699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251004700 S-adenosylmethionine binding site [chemical binding]; other site 718251004701 hypothetical protein; Provisional; Region: PRK02913 718251004702 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 718251004703 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 718251004704 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 718251004705 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 718251004706 active pocket/dimerization site; other site 718251004707 active site 718251004708 phosphorylation site [posttranslational modification] 718251004709 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 718251004710 active site 718251004711 phosphorylation site [posttranslational modification] 718251004712 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 718251004713 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 718251004714 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 718251004715 Transporter associated domain; Region: CorC_HlyC; smart01091 718251004716 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 718251004717 multidrug efflux protein; Reviewed; Region: PRK01766 718251004718 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 718251004719 cation binding site [ion binding]; other site 718251004720 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 718251004721 Lumazine binding domain; Region: Lum_binding; pfam00677 718251004722 Lumazine binding domain; Region: Lum_binding; pfam00677 718251004723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251004724 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 718251004725 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 718251004726 Bacterial transcriptional regulator; Region: IclR; pfam01614 718251004727 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 718251004728 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 718251004729 inner membrane protein; Provisional; Region: PRK11648 718251004730 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 718251004731 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251004732 motif II; other site 718251004733 YniB-like protein; Region: YniB; pfam14002 718251004734 Phosphotransferase enzyme family; Region: APH; pfam01636 718251004735 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 718251004736 active site 718251004737 ATP binding site [chemical binding]; other site 718251004738 hypothetical protein; Provisional; Region: PRK10593 718251004739 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 718251004740 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 718251004741 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 718251004742 N-acetyl-D-glucosamine binding site [chemical binding]; other site 718251004743 catalytic residue [active] 718251004744 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 718251004745 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 718251004746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251004747 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 718251004748 Walker A/P-loop; other site 718251004749 ATP binding site [chemical binding]; other site 718251004750 Q-loop/lid; other site 718251004751 ABC transporter signature motif; other site 718251004752 Walker B; other site 718251004753 D-loop; other site 718251004754 H-loop/switch region; other site 718251004755 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 718251004756 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251004757 Walker A/P-loop; other site 718251004758 ATP binding site [chemical binding]; other site 718251004759 Q-loop/lid; other site 718251004760 ABC transporter signature motif; other site 718251004761 Walker B; other site 718251004762 D-loop; other site 718251004763 H-loop/switch region; other site 718251004764 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 718251004765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251004766 putative PBP binding loops; other site 718251004767 ABC-ATPase subunit interface; other site 718251004768 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 718251004769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251004770 dimer interface [polypeptide binding]; other site 718251004771 conserved gate region; other site 718251004772 putative PBP binding loops; other site 718251004773 ABC-ATPase subunit interface; other site 718251004774 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 718251004775 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 718251004776 Protein of unknown function (DUF805); Region: DUF805; pfam05656 718251004777 penicillin-binding protein 2; Provisional; Region: PRK10795 718251004778 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 718251004779 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 718251004780 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 718251004781 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 718251004782 Ligand Binding Site [chemical binding]; other site 718251004783 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 718251004784 Beta/Gamma crystallin; Region: Crystall; cl02528 718251004785 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 718251004786 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 718251004787 Int/Topo IB signature motif; other site 718251004788 DNA binding site [nucleotide binding] 718251004789 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 718251004790 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 718251004791 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 718251004792 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 718251004793 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 718251004794 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 718251004795 DNA binding residues [nucleotide binding] 718251004796 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 718251004797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251004798 active site 718251004799 phosphorylation site [posttranslational modification] 718251004800 intermolecular recognition site; other site 718251004801 dimerization interface [polypeptide binding]; other site 718251004802 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718251004803 dimerization interface [polypeptide binding]; other site 718251004804 DNA binding residues [nucleotide binding] 718251004805 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 718251004806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251004807 dimer interface [polypeptide binding]; other site 718251004808 phosphorylation site [posttranslational modification] 718251004809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251004810 ATP binding site [chemical binding]; other site 718251004811 Mg2+ binding site [ion binding]; other site 718251004812 G-X-G motif; other site 718251004813 tetrathionate reductase subunit B; Provisional; Region: PRK14993 718251004814 tetrathionate reductase subunit C; Provisional; Region: PRK14992 718251004815 tetrathionate reductase subunit A; Provisional; Region: PRK14991 718251004816 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718251004817 molybdopterin cofactor binding site; other site 718251004818 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718251004819 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 718251004820 putative molybdopterin cofactor binding site; other site 718251004821 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 718251004822 mce related protein; Region: MCE; pfam02470 718251004823 mce related protein; Region: MCE; pfam02470 718251004824 mce related protein; Region: MCE; pfam02470 718251004825 mce related protein; Region: MCE; pfam02470 718251004826 mce related protein; Region: MCE; pfam02470 718251004827 mce related protein; Region: MCE; pfam02470 718251004828 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 718251004829 Paraquat-inducible protein A; Region: PqiA; pfam04403 718251004830 Paraquat-inducible protein A; Region: PqiA; pfam04403 718251004831 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 718251004832 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 718251004833 ProP expression regulator; Provisional; Region: PRK04950 718251004834 ProQ/FINO family; Region: ProQ; pfam04352 718251004835 putative RNA binding sites [nucleotide binding]; other site 718251004836 carboxy-terminal protease; Provisional; Region: PRK11186 718251004837 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 718251004838 protein binding site [polypeptide binding]; other site 718251004839 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 718251004840 Catalytic dyad [active] 718251004841 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 718251004842 alpha-amylase; Reviewed; Region: malS; PRK09505 718251004843 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 718251004844 active site 718251004845 catalytic site [active] 718251004846 heat shock protein HtpX; Provisional; Region: PRK05457 718251004847 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 718251004848 Predicted transcriptional regulator [Transcription]; Region: COG3905 718251004849 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 718251004850 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 718251004851 Glutamate binding site [chemical binding]; other site 718251004852 NAD binding site [chemical binding]; other site 718251004853 catalytic residues [active] 718251004854 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 718251004855 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 718251004856 Na binding site [ion binding]; other site 718251004857 sensor kinase CusS; Provisional; Region: PRK09835 718251004858 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718251004859 dimerization interface [polypeptide binding]; other site 718251004860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251004861 dimer interface [polypeptide binding]; other site 718251004862 phosphorylation site [posttranslational modification] 718251004863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251004864 ATP binding site [chemical binding]; other site 718251004865 Mg2+ binding site [ion binding]; other site 718251004866 G-X-G motif; other site 718251004867 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 718251004868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251004869 active site 718251004870 phosphorylation site [posttranslational modification] 718251004871 intermolecular recognition site; other site 718251004872 dimerization interface [polypeptide binding]; other site 718251004873 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718251004874 DNA binding site [nucleotide binding] 718251004875 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 718251004876 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 718251004877 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 718251004878 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 718251004879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 718251004880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251004881 S-adenosylmethionine binding site [chemical binding]; other site 718251004882 putative transporter; Provisional; Region: PRK11043 718251004883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251004884 putative substrate translocation pore; other site 718251004885 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 718251004886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251004887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718251004888 dimerization interface [polypeptide binding]; other site 718251004889 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 718251004890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251004891 Walker A/P-loop; other site 718251004892 ATP binding site [chemical binding]; other site 718251004893 Q-loop/lid; other site 718251004894 ABC transporter signature motif; other site 718251004895 Walker B; other site 718251004896 D-loop; other site 718251004897 H-loop/switch region; other site 718251004898 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 718251004899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 718251004900 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 718251004901 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718251004902 DNA binding site [nucleotide binding] 718251004903 domain linker motif; other site 718251004904 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 718251004905 dimerization interface [polypeptide binding]; other site 718251004906 ligand binding site [chemical binding]; other site 718251004907 superoxide dismutase; Provisional; Region: PRK10543 718251004908 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 718251004909 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 718251004910 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 718251004911 NlpC/P60 family; Region: NLPC_P60; pfam00877 718251004912 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 718251004913 putative GSH binding site [chemical binding]; other site 718251004914 catalytic residues [active] 718251004915 Predicted permease [General function prediction only]; Region: COG2056 718251004916 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 718251004917 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 718251004918 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 718251004919 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 718251004920 dimer interface [polypeptide binding]; other site 718251004921 catalytic site [active] 718251004922 putative active site [active] 718251004923 putative substrate binding site [chemical binding]; other site 718251004924 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 718251004925 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 718251004926 dimer interface [polypeptide binding]; other site 718251004927 active site 718251004928 metal binding site [ion binding]; metal-binding site 718251004929 glutathione binding site [chemical binding]; other site 718251004930 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 718251004931 MarR family; Region: MarR; pfam01047 718251004932 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 718251004933 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 718251004934 lysozyme inhibitor; Provisional; Region: PRK11372 718251004935 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 718251004936 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 718251004937 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 718251004938 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 718251004939 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 718251004940 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 718251004941 active site 718251004942 HIGH motif; other site 718251004943 dimer interface [polypeptide binding]; other site 718251004944 KMSKS motif; other site 718251004945 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718251004946 RNA binding surface [nucleotide binding]; other site 718251004947 pyridoxamine kinase; Validated; Region: PRK05756 718251004948 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 718251004949 dimer interface [polypeptide binding]; other site 718251004950 pyridoxal binding site [chemical binding]; other site 718251004951 ATP binding site [chemical binding]; other site 718251004952 glutathionine S-transferase; Provisional; Region: PRK10542 718251004953 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 718251004954 C-terminal domain interface [polypeptide binding]; other site 718251004955 GSH binding site (G-site) [chemical binding]; other site 718251004956 dimer interface [polypeptide binding]; other site 718251004957 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 718251004958 dimer interface [polypeptide binding]; other site 718251004959 N-terminal domain interface [polypeptide binding]; other site 718251004960 substrate binding pocket (H-site) [chemical binding]; other site 718251004961 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 718251004962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251004963 putative substrate translocation pore; other site 718251004964 POT family; Region: PTR2; pfam00854 718251004965 endonuclease III; Provisional; Region: PRK10702 718251004966 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 718251004967 minor groove reading motif; other site 718251004968 helix-hairpin-helix signature motif; other site 718251004969 substrate binding pocket [chemical binding]; other site 718251004970 active site 718251004971 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 718251004972 electron transport complex RsxE subunit; Provisional; Region: PRK12405 718251004973 electron transport complex protein RnfG; Validated; Region: PRK01908 718251004974 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 718251004975 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 718251004976 SLBB domain; Region: SLBB; pfam10531 718251004977 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 718251004978 electron transport complex protein RnfB; Provisional; Region: PRK05113 718251004979 Putative Fe-S cluster; Region: FeS; pfam04060 718251004980 4Fe-4S binding domain; Region: Fer4; pfam00037 718251004981 electron transport complex protein RsxA; Provisional; Region: PRK05151 718251004982 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 718251004983 formate--tetrahydrofolate ligase; Provisional; Region: PRK13506 718251004984 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 718251004985 Potassium binding sites [ion binding]; other site 718251004986 Cesium cation binding sites [ion binding]; other site 718251004987 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 718251004988 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 718251004989 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 718251004990 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 718251004991 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 718251004992 active site 718251004993 purine riboside binding site [chemical binding]; other site 718251004994 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 718251004995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 718251004996 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 718251004997 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 718251004998 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 718251004999 Class II fumarases; Region: Fumarase_classII; cd01362 718251005000 fumarate hydratase; Reviewed; Region: fumC; PRK00485 718251005001 active site 718251005002 tetramer interface [polypeptide binding]; other site 718251005003 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 718251005004 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 718251005005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251005006 putative substrate translocation pore; other site 718251005007 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 718251005008 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251005009 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 718251005010 dimerization interface [polypeptide binding]; other site 718251005011 substrate binding pocket [chemical binding]; other site 718251005012 MarR family; Region: MarR_2; cl17246 718251005013 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 718251005014 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 718251005015 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718251005016 AAA domain; Region: AAA_26; pfam13500 718251005017 Haem-binding domain; Region: Haem_bd; pfam14376 718251005018 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 718251005019 CAT RNA binding domain; Region: CAT_RBD; smart01061 718251005020 PRD domain; Region: PRD; pfam00874 718251005021 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 718251005022 active site turn [active] 718251005023 phosphorylation site [posttranslational modification] 718251005024 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 718251005025 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 718251005026 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 718251005027 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 718251005028 beta-galactosidase; Region: BGL; TIGR03356 718251005029 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 718251005030 Major Facilitator Superfamily; Region: MFS_1; pfam07690 718251005031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251005032 putative substrate translocation pore; other site 718251005033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251005034 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 718251005035 hypothetical protein; Provisional; Region: PRK13659 718251005036 malonic semialdehyde reductase; Provisional; Region: PRK10538 718251005037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718251005038 NAD(P) binding site [chemical binding]; other site 718251005039 active site 718251005040 chain length determinant protein WzzB; Provisional; Region: PRK15471 718251005041 Chain length determinant protein; Region: Wzz; pfam02706 718251005042 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 718251005043 dimerization interface [polypeptide binding]; other site 718251005044 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 718251005045 Zn2+ binding site [ion binding]; other site 718251005046 Mg2+ binding site [ion binding]; other site 718251005047 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 718251005048 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 718251005049 Ligand Binding Site [chemical binding]; other site 718251005050 Peptidase family C69; Region: Peptidase_C69; pfam03577 718251005051 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 718251005052 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 718251005053 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 718251005054 dimerization interface [polypeptide binding]; other site 718251005055 putative DNA binding site [nucleotide binding]; other site 718251005056 putative Zn2+ binding site [ion binding]; other site 718251005057 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 718251005058 Cache domain; Region: Cache_1; pfam02743 718251005059 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718251005060 dimerization interface [polypeptide binding]; other site 718251005061 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718251005062 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 718251005063 dimer interface [polypeptide binding]; other site 718251005064 putative CheW interface [polypeptide binding]; other site 718251005065 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 718251005066 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718251005067 hypothetical protein; Provisional; Region: PRK09981 718251005068 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 718251005069 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 718251005070 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 718251005071 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 718251005072 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 718251005073 FAD binding pocket [chemical binding]; other site 718251005074 FAD binding motif [chemical binding]; other site 718251005075 phosphate binding motif [ion binding]; other site 718251005076 beta-alpha-beta structure motif; other site 718251005077 NAD binding pocket [chemical binding]; other site 718251005078 Iron coordination center [ion binding]; other site 718251005079 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 718251005080 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 718251005081 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 718251005082 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 718251005083 Peptidase family U32; Region: Peptidase_U32; pfam01136 718251005084 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 718251005085 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 718251005086 ligand binding site [chemical binding]; other site 718251005087 flexible hinge region; other site 718251005088 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 718251005089 putative switch regulator; other site 718251005090 non-specific DNA interactions [nucleotide binding]; other site 718251005091 DNA binding site [nucleotide binding] 718251005092 sequence specific DNA binding site [nucleotide binding]; other site 718251005093 putative cAMP binding site [chemical binding]; other site 718251005094 universal stress protein UspE; Provisional; Region: PRK11175 718251005095 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 718251005096 Ligand Binding Site [chemical binding]; other site 718251005097 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 718251005098 Ligand Binding Site [chemical binding]; other site 718251005099 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 718251005100 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 718251005101 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 718251005102 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 718251005103 ligand binding site [chemical binding]; other site 718251005104 homodimer interface [polypeptide binding]; other site 718251005105 NAD(P) binding site [chemical binding]; other site 718251005106 trimer interface B [polypeptide binding]; other site 718251005107 trimer interface A [polypeptide binding]; other site 718251005108 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 718251005109 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 718251005110 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 718251005111 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 718251005112 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 718251005113 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK08343 718251005114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718251005115 dihydromonapterin reductase; Provisional; Region: PRK06483 718251005116 NAD(P) binding site [chemical binding]; other site 718251005117 active site 718251005118 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 718251005119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251005120 active site 718251005121 phosphorylation site [posttranslational modification] 718251005122 intermolecular recognition site; other site 718251005123 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718251005124 DNA binding site [nucleotide binding] 718251005125 sensor protein RstB; Provisional; Region: PRK10604 718251005126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718251005127 dimerization interface [polypeptide binding]; other site 718251005128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251005129 dimer interface [polypeptide binding]; other site 718251005130 phosphorylation site [posttranslational modification] 718251005131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251005132 ATP binding site [chemical binding]; other site 718251005133 Mg2+ binding site [ion binding]; other site 718251005134 G-X-G motif; other site 718251005135 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 718251005136 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 718251005137 active site 718251005138 Zn binding site [ion binding]; other site 718251005139 type III effector phosphothreonine lyase; Provisional; Region: PRK15245 718251005140 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 718251005141 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 718251005142 catalytic core [active] 718251005143 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 718251005144 putative transposase OrfB; Reviewed; Region: PHA02517 718251005145 Helix-Turn-Helix DNA binding domain of the Cfa transcription regulator; Region: HTH_Cfa; cd04789 718251005146 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 718251005147 DNA binding residues [nucleotide binding] 718251005148 putative dimer interface [polypeptide binding]; other site 718251005149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251005150 S-adenosylmethionine binding site [chemical binding]; other site 718251005151 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 718251005152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718251005153 Coenzyme A binding pocket [chemical binding]; other site 718251005154 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 718251005155 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 718251005156 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718251005157 ATP binding site [chemical binding]; other site 718251005158 putative Mg++ binding site [ion binding]; other site 718251005159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718251005160 nucleotide binding region [chemical binding]; other site 718251005161 ATP-binding site [chemical binding]; other site 718251005162 Helicase associated domain (HA2); Region: HA2; pfam04408 718251005163 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 718251005164 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 718251005165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 718251005166 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 718251005167 hypothetical protein; Provisional; Region: PRK10695 718251005168 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 718251005169 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 718251005170 putative ligand binding site [chemical binding]; other site 718251005171 putative NAD binding site [chemical binding]; other site 718251005172 catalytic site [active] 718251005173 Glycogen synthesis protein; Region: GlgS; cl11663 718251005174 META domain; Region: META; cl01245 718251005175 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 718251005176 Domain of unknown function (DUF333); Region: DUF333; pfam03891 718251005177 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 718251005178 MgtC family; Region: MgtC; pfam02308 718251005179 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 718251005180 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 718251005181 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 718251005182 dimer interface [polypeptide binding]; other site 718251005183 PYR/PP interface [polypeptide binding]; other site 718251005184 TPP binding site [chemical binding]; other site 718251005185 substrate binding site [chemical binding]; other site 718251005186 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 718251005187 Domain of unknown function; Region: EKR; pfam10371 718251005188 4Fe-4S binding domain; Region: Fer4_6; pfam12837 718251005189 4Fe-4S binding domain; Region: Fer4; pfam00037 718251005190 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 718251005191 TPP-binding site [chemical binding]; other site 718251005192 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 718251005193 4Fe-4S binding domain; Region: Fer4; pfam00037 718251005194 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718251005195 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718251005196 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 718251005197 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 718251005198 Ligand Binding Site [chemical binding]; other site 718251005199 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 718251005200 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 718251005201 Cl binding site [ion binding]; other site 718251005202 oligomer interface [polypeptide binding]; other site 718251005203 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 718251005204 CoenzymeA binding site [chemical binding]; other site 718251005205 subunit interaction site [polypeptide binding]; other site 718251005206 PHB binding site; other site 718251005207 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 718251005208 FAD binding domain; Region: FAD_binding_4; pfam01565 718251005209 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 718251005210 putative inner membrane protein; Provisional; Region: PRK10983 718251005211 Domain of unknown function DUF20; Region: UPF0118; pfam01594 718251005212 phosphoenolpyruvate synthase; Validated; Region: PRK06464 718251005213 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 718251005214 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 718251005215 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 718251005216 PEP synthetase regulatory protein; Provisional; Region: PRK05339 718251005217 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 718251005218 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 718251005219 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 718251005220 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718251005221 FeS/SAM binding site; other site 718251005222 putative heme utilization carrier protein HutX; Region: HutX; TIGR04108 718251005223 NADH(P)-binding; Region: NAD_binding_10; pfam13460 718251005224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718251005225 NAD(P) binding site [chemical binding]; other site 718251005226 active site 718251005227 Hemin uptake protein hemP; Region: hemP; pfam10636 718251005228 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 718251005229 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718251005230 N-terminal plug; other site 718251005231 ligand-binding site [chemical binding]; other site 718251005232 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 718251005233 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 718251005234 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 718251005235 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 718251005236 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 718251005237 putative hemin binding site; other site 718251005238 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 718251005239 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718251005240 ABC-ATPase subunit interface; other site 718251005241 dimer interface [polypeptide binding]; other site 718251005242 putative PBP binding regions; other site 718251005243 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 718251005244 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 718251005245 Walker A/P-loop; other site 718251005246 ATP binding site [chemical binding]; other site 718251005247 Q-loop/lid; other site 718251005248 ABC transporter signature motif; other site 718251005249 Walker B; other site 718251005250 D-loop; other site 718251005251 H-loop/switch region; other site 718251005252 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 718251005253 Na binding site [ion binding]; other site 718251005254 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 718251005255 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 718251005256 substrate binding site [chemical binding]; other site 718251005257 ATP binding site [chemical binding]; other site 718251005258 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 718251005259 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 718251005260 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 718251005261 NlpC/P60 family; Region: NLPC_P60; pfam00877 718251005262 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 718251005263 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 718251005264 Walker A/P-loop; other site 718251005265 ATP binding site [chemical binding]; other site 718251005266 Q-loop/lid; other site 718251005267 ABC transporter signature motif; other site 718251005268 Walker B; other site 718251005269 D-loop; other site 718251005270 H-loop/switch region; other site 718251005271 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 718251005272 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718251005273 ABC-ATPase subunit interface; other site 718251005274 dimer interface [polypeptide binding]; other site 718251005275 putative PBP binding regions; other site 718251005276 hypothetical protein; Provisional; Region: PRK10708 718251005277 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 718251005278 IHF dimer interface [polypeptide binding]; other site 718251005279 IHF - DNA interface [nucleotide binding]; other site 718251005280 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 718251005281 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 718251005282 putative tRNA-binding site [nucleotide binding]; other site 718251005283 B3/4 domain; Region: B3_4; pfam03483 718251005284 tRNA synthetase B5 domain; Region: B5; smart00874 718251005285 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 718251005286 dimer interface [polypeptide binding]; other site 718251005287 motif 1; other site 718251005288 motif 3; other site 718251005289 motif 2; other site 718251005290 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 718251005291 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 718251005292 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 718251005293 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 718251005294 dimer interface [polypeptide binding]; other site 718251005295 motif 1; other site 718251005296 active site 718251005297 motif 2; other site 718251005298 motif 3; other site 718251005299 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 718251005300 23S rRNA binding site [nucleotide binding]; other site 718251005301 L21 binding site [polypeptide binding]; other site 718251005302 L13 binding site [polypeptide binding]; other site 718251005303 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 718251005304 translation initiation factor IF-3; Region: infC; TIGR00168 718251005305 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 718251005306 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 718251005307 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 718251005308 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 718251005309 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 718251005310 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 718251005311 active site 718251005312 dimer interface [polypeptide binding]; other site 718251005313 motif 1; other site 718251005314 motif 2; other site 718251005315 motif 3; other site 718251005316 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 718251005317 anticodon binding site; other site 718251005318 BCCT family transporter; Region: BCCT; cl00569 718251005319 YobH-like protein; Region: YobH; pfam13996 718251005320 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 718251005321 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 718251005322 dimerization interface [polypeptide binding]; other site 718251005323 DPS ferroxidase diiron center [ion binding]; other site 718251005324 ion pore; other site 718251005325 6-phosphofructokinase 2; Provisional; Region: PRK10294 718251005326 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 718251005327 putative substrate binding site [chemical binding]; other site 718251005328 putative ATP binding site [chemical binding]; other site 718251005329 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 718251005330 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 718251005331 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 718251005332 trimer interface [polypeptide binding]; other site 718251005333 eyelet of channel; other site 718251005334 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 718251005335 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 718251005336 protease 2; Provisional; Region: PRK10115 718251005337 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 718251005338 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718251005339 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 718251005340 YebG protein; Region: YebG; pfam07130 718251005341 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 718251005342 DNA-binding site [nucleotide binding]; DNA binding site 718251005343 RNA-binding motif; other site 718251005344 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 718251005345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 718251005346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251005347 S-adenosylmethionine binding site [chemical binding]; other site 718251005348 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 718251005349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718251005350 ATP-grasp domain; Region: ATP-grasp; pfam02222 718251005351 hypothetical protein; Provisional; Region: PRK05114 718251005352 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 718251005353 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 718251005354 chorismate binding enzyme; Region: Chorismate_bind; cl10555 718251005355 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 718251005356 putative active site [active] 718251005357 putative CoA binding site [chemical binding]; other site 718251005358 nudix motif; other site 718251005359 metal binding site [ion binding]; metal-binding site 718251005360 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 718251005361 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 718251005362 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 718251005363 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 718251005364 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 718251005365 4Fe-4S binding domain; Region: Fer4; cl02805 718251005366 thiosulfate reductase PhsA; Provisional; Region: PRK15488 718251005367 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 718251005368 putative [Fe4-S4] binding site [ion binding]; other site 718251005369 putative molybdopterin cofactor binding site [chemical binding]; other site 718251005370 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718251005371 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 718251005372 putative molybdopterin cofactor binding site; other site 718251005373 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 718251005374 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 718251005375 putative dimer interface [polypeptide binding]; other site 718251005376 active site pocket [active] 718251005377 putative cataytic base [active] 718251005378 cobyric acid synthase; Provisional; Region: PRK00784 718251005379 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718251005380 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718251005381 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 718251005382 catalytic triad [active] 718251005383 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 718251005384 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718251005385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251005386 homodimer interface [polypeptide binding]; other site 718251005387 catalytic residue [active] 718251005388 pyruvate kinase; Provisional; Region: PRK09206 718251005389 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 718251005390 domain interfaces; other site 718251005391 active site 718251005392 murein lipoprotein; Provisional; Region: PRK15396 718251005393 L,D-transpeptidase; Provisional; Region: PRK10190 718251005394 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 718251005395 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 718251005396 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 718251005397 peptide binding site [polypeptide binding]; other site 718251005398 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 718251005399 dimer interface [polypeptide binding]; other site 718251005400 catalytic triad [active] 718251005401 peroxidatic and resolving cysteines [active] 718251005402 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 718251005403 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 718251005404 putative aromatic amino acid binding site; other site 718251005405 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718251005406 putative active site [active] 718251005407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251005408 Walker A motif; other site 718251005409 ATP binding site [chemical binding]; other site 718251005410 Walker B motif; other site 718251005411 arginine finger; other site 718251005412 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 718251005413 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 718251005414 active site residue [active] 718251005415 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 718251005416 active site residue [active] 718251005417 hypothetical protein; Provisional; Region: PRK05415 718251005418 Domain of unknown function (DUF697); Region: DUF697; cl12064 718251005419 Predicted ATPase [General function prediction only]; Region: COG3106 718251005420 Phage shock protein PspD (Phageshock_PspD); Region: Phageshock_PspD; cl11512 718251005421 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 718251005422 phage shock protein C; Region: phageshock_pspC; TIGR02978 718251005423 phage shock protein B; Provisional; Region: pspB; PRK09458 718251005424 phage shock protein PspA; Provisional; Region: PRK10698 718251005425 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 718251005426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251005427 Walker A motif; other site 718251005428 ATP binding site [chemical binding]; other site 718251005429 Walker B motif; other site 718251005430 arginine finger; other site 718251005431 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 718251005432 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 718251005433 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 718251005434 peptide binding site [polypeptide binding]; other site 718251005435 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 718251005436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251005437 dimer interface [polypeptide binding]; other site 718251005438 conserved gate region; other site 718251005439 putative PBP binding loops; other site 718251005440 ABC-ATPase subunit interface; other site 718251005441 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 718251005442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251005443 dimer interface [polypeptide binding]; other site 718251005444 conserved gate region; other site 718251005445 putative PBP binding loops; other site 718251005446 ABC-ATPase subunit interface; other site 718251005447 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 718251005448 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718251005449 Walker A/P-loop; other site 718251005450 ATP binding site [chemical binding]; other site 718251005451 Q-loop/lid; other site 718251005452 ABC transporter signature motif; other site 718251005453 Walker B; other site 718251005454 D-loop; other site 718251005455 H-loop/switch region; other site 718251005456 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 718251005457 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 718251005458 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718251005459 Walker A/P-loop; other site 718251005460 ATP binding site [chemical binding]; other site 718251005461 Q-loop/lid; other site 718251005462 ABC transporter signature motif; other site 718251005463 Walker B; other site 718251005464 D-loop; other site 718251005465 H-loop/switch region; other site 718251005466 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 718251005467 Mechanosensitive ion channel; Region: MS_channel; pfam00924 718251005468 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 718251005469 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 718251005470 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 718251005471 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 718251005472 AMP nucleosidase; Provisional; Region: PRK08292 718251005473 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 718251005474 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 718251005475 exoribonuclease II; Provisional; Region: PRK05054 718251005476 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 718251005477 RNB domain; Region: RNB; pfam00773 718251005478 S1 RNA binding domain; Region: S1; pfam00575 718251005479 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 718251005480 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 718251005481 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 718251005482 metal binding site [ion binding]; metal-binding site 718251005483 dimer interface [polypeptide binding]; other site 718251005484 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 718251005485 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 718251005486 Walker A/P-loop; other site 718251005487 ATP binding site [chemical binding]; other site 718251005488 Q-loop/lid; other site 718251005489 ABC transporter signature motif; other site 718251005490 Walker B; other site 718251005491 D-loop; other site 718251005492 H-loop/switch region; other site 718251005493 TOBE domain; Region: TOBE_2; pfam08402 718251005494 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 718251005495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251005496 dimer interface [polypeptide binding]; other site 718251005497 conserved gate region; other site 718251005498 putative PBP binding loops; other site 718251005499 ABC-ATPase subunit interface; other site 718251005500 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 718251005501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251005502 dimer interface [polypeptide binding]; other site 718251005503 conserved gate region; other site 718251005504 putative PBP binding loops; other site 718251005505 ABC-ATPase subunit interface; other site 718251005506 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 718251005507 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 718251005508 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 718251005509 hypothetical protein; Provisional; Region: PRK04940 718251005510 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 718251005511 beta-hexosaminidase; Provisional; Region: PRK05337 718251005512 thiamine kinase; Region: ycfN_thiK; TIGR02721 718251005513 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 718251005514 substrate binding site [chemical binding]; other site 718251005515 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 718251005516 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 718251005517 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 718251005518 putative dimer interface [polypeptide binding]; other site 718251005519 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 718251005520 nucleotide binding site/active site [active] 718251005521 HIT family signature motif; other site 718251005522 catalytic residue [active] 718251005523 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 718251005524 dimer interface [polypeptide binding]; other site 718251005525 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 718251005526 dimer interface [polypeptide binding]; other site 718251005527 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 718251005528 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 718251005529 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 718251005530 NADP binding site [chemical binding]; other site 718251005531 homodimer interface [polypeptide binding]; other site 718251005532 active site 718251005533 YadA-like C-terminal region; Region: YadA; pfam03895 718251005534 putative outer membrane lipoprotein; Provisional; Region: PRK09967 718251005535 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 718251005536 ligand binding site [chemical binding]; other site 718251005537 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 718251005538 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718251005539 metal binding site [ion binding]; metal-binding site 718251005540 active site 718251005541 I-site; other site 718251005542 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 718251005543 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 718251005544 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 718251005545 Ligand Binding Site [chemical binding]; other site 718251005546 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 718251005547 CHASE domain; Region: CHASE; pfam03924 718251005548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718251005549 PAS domain; Region: PAS_9; pfam13426 718251005550 putative active site [active] 718251005551 heme pocket [chemical binding]; other site 718251005552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718251005553 PAS domain; Region: PAS_9; pfam13426 718251005554 putative active site [active] 718251005555 heme pocket [chemical binding]; other site 718251005556 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 718251005557 putative active site [active] 718251005558 heme pocket [chemical binding]; other site 718251005559 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251005560 dimer interface [polypeptide binding]; other site 718251005561 phosphorylation site [posttranslational modification] 718251005562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251005563 ATP binding site [chemical binding]; other site 718251005564 Mg2+ binding site [ion binding]; other site 718251005565 G-X-G motif; other site 718251005566 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 718251005567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251005568 active site 718251005569 phosphorylation site [posttranslational modification] 718251005570 intermolecular recognition site; other site 718251005571 dimerization interface [polypeptide binding]; other site 718251005572 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 718251005573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251005574 active site 718251005575 phosphorylation site [posttranslational modification] 718251005576 intermolecular recognition site; other site 718251005577 dimerization interface [polypeptide binding]; other site 718251005578 Hpt domain; Region: Hpt; pfam01627 718251005579 putative binding surface; other site 718251005580 active site 718251005581 Response regulator receiver domain; Region: Response_reg; pfam00072 718251005582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251005583 active site 718251005584 phosphorylation site [posttranslational modification] 718251005585 intermolecular recognition site; other site 718251005586 dimerization interface [polypeptide binding]; other site 718251005587 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 718251005588 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718251005589 metal binding site [ion binding]; metal-binding site 718251005590 active site 718251005591 I-site; other site 718251005592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251005593 D-galactonate transporter; Region: 2A0114; TIGR00893 718251005594 putative substrate translocation pore; other site 718251005595 Beta/Gamma crystallin; Region: Crystall; cl02528 718251005596 alpha-galactosidase; Provisional; Region: PRK15076 718251005597 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 718251005598 NAD binding site [chemical binding]; other site 718251005599 sugar binding site [chemical binding]; other site 718251005600 divalent metal binding site [ion binding]; other site 718251005601 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 718251005602 dimer interface [polypeptide binding]; other site 718251005603 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 718251005604 Cupin domain; Region: Cupin_2; cl17218 718251005605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718251005606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718251005607 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718251005608 binding surface 718251005609 Tetratricopeptide repeat; Region: TPR_16; pfam13432 718251005610 TPR motif; other site 718251005611 Protein of unknown function (DUF560); Region: DUF560; pfam04575 718251005612 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 718251005613 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 718251005614 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 718251005615 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718251005616 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 718251005617 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 718251005618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 718251005619 putative aldolase; Validated; Region: PRK08130 718251005620 intersubunit interface [polypeptide binding]; other site 718251005621 active site 718251005622 Zn2+ binding site [ion binding]; other site 718251005623 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 718251005624 putative transporter; Provisional; Region: PRK09821 718251005625 GntP family permease; Region: GntP_permease; pfam02447 718251005626 Domain of unknown function (DUF305); Region: DUF305; cl17794 718251005627 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 718251005628 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 718251005629 dimer interface [polypeptide binding]; other site 718251005630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251005631 catalytic residue [active] 718251005632 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 718251005633 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 718251005634 homodimer interface [polypeptide binding]; other site 718251005635 substrate-cofactor binding pocket; other site 718251005636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251005637 catalytic residue [active] 718251005638 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 718251005639 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 718251005640 dimer interface [polypeptide binding]; other site 718251005641 PYR/PP interface [polypeptide binding]; other site 718251005642 TPP binding site [chemical binding]; other site 718251005643 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 718251005644 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 718251005645 TPP-binding site [chemical binding]; other site 718251005646 dimer interface [polypeptide binding]; other site 718251005647 OpgC protein; Region: OpgC_C; cl17858 718251005648 Acyltransferase family; Region: Acyl_transf_3; pfam01757 718251005649 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 718251005650 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 718251005651 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 718251005652 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 718251005653 DXD motif; other site 718251005654 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 718251005655 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 718251005656 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 718251005657 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 718251005658 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 718251005659 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 718251005660 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 718251005661 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 718251005662 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 718251005663 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 718251005664 Coenzyme A binding pocket [chemical binding]; other site 718251005665 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 718251005666 Bacterial sugar transferase; Region: Bac_transf; pfam02397 718251005667 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 718251005668 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 718251005669 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 718251005670 SLBB domain; Region: SLBB; pfam10531 718251005671 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 718251005672 Chain length determinant protein; Region: Wzz; cl15801 718251005673 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 718251005674 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 718251005675 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 718251005676 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 718251005677 active site 718251005678 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718251005679 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 718251005680 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 718251005681 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 718251005682 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 718251005683 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 718251005684 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 718251005685 trimer interface [polypeptide binding]; other site 718251005686 active site 718251005687 substrate binding site [chemical binding]; other site 718251005688 CoA binding site [chemical binding]; other site 718251005689 Mig-14; Region: Mig-14; pfam07395 718251005690 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 718251005691 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 718251005692 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 718251005693 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 718251005694 ABC-ATPase subunit interface; other site 718251005695 dimer interface [polypeptide binding]; other site 718251005696 putative PBP binding regions; other site 718251005697 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 718251005698 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 718251005699 Walker A/P-loop; other site 718251005700 ATP binding site [chemical binding]; other site 718251005701 Q-loop/lid; other site 718251005702 ABC transporter signature motif; other site 718251005703 Walker B; other site 718251005704 D-loop; other site 718251005705 H-loop/switch region; other site 718251005706 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 718251005707 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 718251005708 IucA / IucC family; Region: IucA_IucC; pfam04183 718251005709 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 718251005710 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 718251005711 IucA / IucC family; Region: IucA_IucC; pfam04183 718251005712 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 718251005713 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 718251005714 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 718251005715 dimer interface [polypeptide binding]; other site 718251005716 active site 718251005717 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 718251005718 catalytic residues [active] 718251005719 substrate binding site [chemical binding]; other site 718251005720 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 718251005721 intersubunit interface [polypeptide binding]; other site 718251005722 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 718251005723 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718251005724 N-terminal plug; other site 718251005725 ligand-binding site [chemical binding]; other site 718251005726 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 718251005727 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 718251005728 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 718251005729 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 718251005730 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 718251005731 active site 718251005732 catalytic residues [active] 718251005733 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 718251005734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251005735 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 718251005736 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 718251005737 substrate binding site [chemical binding]; other site 718251005738 dimer interface [polypeptide binding]; other site 718251005739 ATP binding site [chemical binding]; other site 718251005740 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 718251005741 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 718251005742 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718251005743 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 718251005744 SnoaL-like domain; Region: SnoaL_3; pfam13474 718251005745 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 718251005746 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 718251005747 substrate binding site [chemical binding]; other site 718251005748 PrpF protein; Region: PrpF; pfam04303 718251005749 Propionate catabolism activator; Region: PrpR_N; pfam06506 718251005750 PAS domain; Region: PAS; smart00091 718251005751 PAS domain; Region: PAS_9; pfam13426 718251005752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251005753 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 718251005754 Walker A motif; other site 718251005755 ATP binding site [chemical binding]; other site 718251005756 Walker B motif; other site 718251005757 arginine finger; other site 718251005758 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 718251005759 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 718251005760 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 718251005761 homotrimer interface [polypeptide binding]; other site 718251005762 Walker A motif; other site 718251005763 GTP binding site [chemical binding]; other site 718251005764 Walker B motif; other site 718251005765 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 718251005766 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 718251005767 Walker A/P-loop; other site 718251005768 ATP binding site [chemical binding]; other site 718251005769 Q-loop/lid; other site 718251005770 ABC transporter signature motif; other site 718251005771 Walker B; other site 718251005772 D-loop; other site 718251005773 H-loop/switch region; other site 718251005774 cobyric acid synthase; Provisional; Region: PRK00784 718251005775 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718251005776 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718251005777 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 718251005778 catalytic triad [active] 718251005779 cobalt transport protein CbiQ; Provisional; Region: PRK15485 718251005780 cobalt transport protein CbiN; Provisional; Region: PRK02898 718251005781 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 718251005782 cobalt transport protein CbiM; Validated; Region: PRK08319 718251005783 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 718251005784 active site 718251005785 SAM binding site [chemical binding]; other site 718251005786 homodimer interface [polypeptide binding]; other site 718251005787 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 718251005788 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 718251005789 active site 718251005790 C-terminal domain interface [polypeptide binding]; other site 718251005791 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 718251005792 active site 718251005793 N-terminal domain interface [polypeptide binding]; other site 718251005794 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 718251005795 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 718251005796 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 718251005797 active site 718251005798 SAM binding site [chemical binding]; other site 718251005799 homodimer interface [polypeptide binding]; other site 718251005800 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 718251005801 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 718251005802 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 718251005803 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 718251005804 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 718251005805 active site 718251005806 SAM binding site [chemical binding]; other site 718251005807 homodimer interface [polypeptide binding]; other site 718251005808 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 718251005809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251005810 S-adenosylmethionine binding site [chemical binding]; other site 718251005811 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 718251005812 putative homodimer interface [polypeptide binding]; other site 718251005813 active site 718251005814 SAM binding site [chemical binding]; other site 718251005815 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 718251005816 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 718251005817 Precorrin-8X methylmutase; Region: CbiC; pfam02570 718251005818 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 718251005819 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 718251005820 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 718251005821 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 718251005822 catalytic triad [active] 718251005823 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 718251005824 sensory histidine kinase AtoS; Provisional; Region: PRK11360 718251005825 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718251005826 putative active site [active] 718251005827 heme pocket [chemical binding]; other site 718251005828 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251005829 dimer interface [polypeptide binding]; other site 718251005830 phosphorylation site [posttranslational modification] 718251005831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251005832 ATP binding site [chemical binding]; other site 718251005833 Mg2+ binding site [ion binding]; other site 718251005834 G-X-G motif; other site 718251005835 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 718251005836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251005837 active site 718251005838 phosphorylation site [posttranslational modification] 718251005839 intermolecular recognition site; other site 718251005840 dimerization interface [polypeptide binding]; other site 718251005841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251005842 Walker A motif; other site 718251005843 ATP binding site [chemical binding]; other site 718251005844 Walker B motif; other site 718251005845 arginine finger; other site 718251005846 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 718251005847 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 718251005848 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 718251005849 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 718251005850 putative acyltransferase; Provisional; Region: PRK05790 718251005851 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 718251005852 dimer interface [polypeptide binding]; other site 718251005853 active site 718251005854 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 718251005855 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 718251005856 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 718251005857 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718251005858 HlyD family secretion protein; Region: HlyD_3; pfam13437 718251005859 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 718251005860 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 718251005861 Condensation domain; Region: Condensation; pfam00668 718251005862 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 718251005863 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 718251005864 acyl-activating enzyme (AAE) consensus motif; other site 718251005865 AMP binding site [chemical binding]; other site 718251005866 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 718251005867 Condensation domain; Region: Condensation; pfam00668 718251005868 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 718251005869 Condensation domain; Region: Condensation; pfam00668 718251005870 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 718251005871 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 718251005872 Zn binding site [ion binding]; other site 718251005873 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 718251005874 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 718251005875 Propionate catabolism activator; Region: PrpR_N; pfam06506 718251005876 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 718251005877 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718251005878 putative active site [active] 718251005879 heme pocket [chemical binding]; other site 718251005880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251005881 Walker A motif; other site 718251005882 ATP binding site [chemical binding]; other site 718251005883 Walker B motif; other site 718251005884 arginine finger; other site 718251005885 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 718251005886 CoA-transferase family III; Region: CoA_transf_3; pfam02515 718251005887 3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism]; Region: LeuC; COG0065 718251005888 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 718251005889 substrate binding site [chemical binding]; other site 718251005890 ligand binding site [chemical binding]; other site 718251005891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 718251005892 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 718251005893 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 718251005894 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 718251005895 GIY-YIG motif/motif A; other site 718251005896 active site 718251005897 catalytic site [active] 718251005898 putative DNA binding site [nucleotide binding]; other site 718251005899 metal binding site [ion binding]; metal-binding site 718251005900 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 718251005901 response regulator; Provisional; Region: PRK09483 718251005902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251005903 active site 718251005904 phosphorylation site [posttranslational modification] 718251005905 intermolecular recognition site; other site 718251005906 dimerization interface [polypeptide binding]; other site 718251005907 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718251005908 DNA binding residues [nucleotide binding] 718251005909 dimerization interface [polypeptide binding]; other site 718251005910 hypothetical protein; Provisional; Region: PRK10613 718251005911 GlpM protein; Region: GlpM; cl01212 718251005912 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 718251005913 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 718251005914 conserved cys residue [active] 718251005915 chaperone protein HchA; Provisional; Region: PRK04155 718251005916 isocitrate dehydrogenase; Validated; Region: PRK07362 718251005917 isocitrate dehydrogenase; Reviewed; Region: PRK07006 718251005918 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 718251005919 pseudouridine synthase; Region: TIGR00093 718251005920 active site 718251005921 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 718251005922 nudix motif; other site 718251005923 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 718251005924 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 718251005925 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 718251005926 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718251005927 metal binding site [ion binding]; metal-binding site 718251005928 active site 718251005929 I-site; other site 718251005930 putative lysogenization regulator; Reviewed; Region: PRK00218 718251005931 adenylosuccinate lyase; Provisional; Region: PRK09285 718251005932 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 718251005933 tetramer interface [polypeptide binding]; other site 718251005934 active site 718251005935 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 718251005936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718251005937 DNA-binding site [nucleotide binding]; DNA binding site 718251005938 UTRA domain; Region: UTRA; pfam07702 718251005939 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 718251005940 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 718251005941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251005942 active site 718251005943 phosphorylation site [posttranslational modification] 718251005944 intermolecular recognition site; other site 718251005945 dimerization interface [polypeptide binding]; other site 718251005946 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718251005947 DNA binding site [nucleotide binding] 718251005948 sensor protein PhoQ; Provisional; Region: PRK10815 718251005949 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 718251005950 HAMP domain; Region: HAMP; pfam00672 718251005951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251005952 dimer interface [polypeptide binding]; other site 718251005953 phosphorylation site [posttranslational modification] 718251005954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251005955 ATP binding site [chemical binding]; other site 718251005956 Mg2+ binding site [ion binding]; other site 718251005957 G-X-G motif; other site 718251005958 Uncharacterized conserved protein [Function unknown]; Region: COG2850 718251005959 NAD-dependent deacetylase; Provisional; Region: PRK00481 718251005960 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 718251005961 NAD+ binding site [chemical binding]; other site 718251005962 substrate binding site [chemical binding]; other site 718251005963 Zn binding site [ion binding]; other site 718251005964 fructokinase; Reviewed; Region: PRK09557 718251005965 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 718251005966 nucleotide binding site [chemical binding]; other site 718251005967 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 718251005968 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 718251005969 FtsX-like permease family; Region: FtsX; pfam02687 718251005970 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 718251005971 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 718251005972 Walker A/P-loop; other site 718251005973 ATP binding site [chemical binding]; other site 718251005974 Q-loop/lid; other site 718251005975 ABC transporter signature motif; other site 718251005976 Walker B; other site 718251005977 D-loop; other site 718251005978 H-loop/switch region; other site 718251005979 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 718251005980 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 718251005981 FtsX-like permease family; Region: FtsX; pfam02687 718251005982 transcription-repair coupling factor; Provisional; Region: PRK10689 718251005983 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 718251005984 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718251005985 ATP binding site [chemical binding]; other site 718251005986 putative Mg++ binding site [ion binding]; other site 718251005987 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718251005988 nucleotide binding region [chemical binding]; other site 718251005989 ATP-binding site [chemical binding]; other site 718251005990 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 718251005991 hypothetical protein; Provisional; Region: PRK11280 718251005992 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 718251005993 EamA-like transporter family; Region: EamA; pfam00892 718251005994 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 718251005995 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718251005996 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 718251005997 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 718251005998 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718251005999 DinI-like family; Region: DinI; cl11630 718251006000 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 718251006001 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 718251006002 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 718251006003 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718251006004 DNA binding residues [nucleotide binding] 718251006005 dimerization interface [polypeptide binding]; other site 718251006006 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 718251006007 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718251006008 DNA-binding site [nucleotide binding]; DNA binding site 718251006009 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718251006010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251006011 homodimer interface [polypeptide binding]; other site 718251006012 catalytic residue [active] 718251006013 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 718251006014 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 718251006015 lipoprotein; Provisional; Region: PRK10540 718251006016 translation initiation factor Sui1; Validated; Region: PRK06824 718251006017 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 718251006018 putative rRNA binding site [nucleotide binding]; other site 718251006019 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 718251006020 active site 718251006021 dimer interface [polypeptide binding]; other site 718251006022 tetratricopeptide repeat protein; Provisional; Region: PRK11788 718251006023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718251006024 TPR motif; other site 718251006025 binding surface 718251006026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718251006027 binding surface 718251006028 TPR motif; other site 718251006029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 718251006030 binding surface 718251006031 TPR motif; other site 718251006032 Predicted membrane protein [Function unknown]; Region: COG3771 718251006033 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 718251006034 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 718251006035 active site 718251006036 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 718251006037 dimerization interface [polypeptide binding]; other site 718251006038 active site 718251006039 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 718251006040 Autotransporter beta-domain; Region: Autotransporter; pfam03797 718251006041 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 718251006042 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 718251006043 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 718251006044 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 718251006045 active site turn [active] 718251006046 phosphorylation site [posttranslational modification] 718251006047 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 718251006048 active site 718251006049 DNA polymerase III subunit delta'; Validated; Region: PRK07993 718251006050 DNA polymerase III subunit delta'; Validated; Region: PRK08485 718251006051 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 718251006052 thymidylate kinase; Validated; Region: tmk; PRK00698 718251006053 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 718251006054 TMP-binding site; other site 718251006055 ATP-binding site [chemical binding]; other site 718251006056 YceG-like family; Region: YceG; pfam02618 718251006057 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 718251006058 dimerization interface [polypeptide binding]; other site 718251006059 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 718251006060 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 718251006061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251006062 catalytic residue [active] 718251006063 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 718251006064 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 718251006065 dimer interface [polypeptide binding]; other site 718251006066 active site 718251006067 acyl carrier protein; Provisional; Region: acpP; PRK00982 718251006068 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 718251006069 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 718251006070 NAD(P) binding site [chemical binding]; other site 718251006071 homotetramer interface [polypeptide binding]; other site 718251006072 homodimer interface [polypeptide binding]; other site 718251006073 active site 718251006074 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 718251006075 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 718251006076 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 718251006077 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 718251006078 dimer interface [polypeptide binding]; other site 718251006079 active site 718251006080 CoA binding pocket [chemical binding]; other site 718251006081 putative phosphate acyltransferase; Provisional; Region: PRK05331 718251006082 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 718251006083 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 718251006084 Maf-like protein; Region: Maf; pfam02545 718251006085 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 718251006086 active site 718251006087 dimer interface [polypeptide binding]; other site 718251006088 YadA-like C-terminal region; Region: YadA; pfam03895 718251006089 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 718251006090 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718251006091 RNA binding surface [nucleotide binding]; other site 718251006092 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 718251006093 active site 718251006094 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 718251006095 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 718251006096 homodimer interface [polypeptide binding]; other site 718251006097 oligonucleotide binding site [chemical binding]; other site 718251006098 Uncharacterized conserved protein [Function unknown]; Region: COG1359 718251006099 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 718251006100 active site 718251006101 substrate binding pocket [chemical binding]; other site 718251006102 dimer interface [polypeptide binding]; other site 718251006103 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 718251006104 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 718251006105 Walker A/P-loop; other site 718251006106 ATP binding site [chemical binding]; other site 718251006107 Q-loop/lid; other site 718251006108 ABC transporter signature motif; other site 718251006109 Walker B; other site 718251006110 D-loop; other site 718251006111 H-loop/switch region; other site 718251006112 TIGR00245 family protein; Region: TIGR00245 718251006113 fumarate hydratase; Provisional; Region: PRK15389 718251006114 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 718251006115 Fumarase C-terminus; Region: Fumerase_C; pfam05683 718251006116 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718251006117 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251006118 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 718251006119 putative dimerization interface [polypeptide binding]; other site 718251006120 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 718251006121 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 718251006122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718251006123 NAD(P) binding site [chemical binding]; other site 718251006124 active site 718251006125 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 718251006126 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 718251006127 putative acyltransferase; Provisional; Region: PRK05790 718251006128 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 718251006129 dimer interface [polypeptide binding]; other site 718251006130 active site 718251006131 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 718251006132 amphipathic channel; other site 718251006133 Asn-Pro-Ala signature motifs; other site 718251006134 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 718251006135 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 718251006136 Walker A/P-loop; other site 718251006137 ATP binding site [chemical binding]; other site 718251006138 Q-loop/lid; other site 718251006139 ABC transporter signature motif; other site 718251006140 Walker B; other site 718251006141 D-loop; other site 718251006142 H-loop/switch region; other site 718251006143 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 718251006144 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 718251006145 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 718251006146 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 718251006147 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 718251006148 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 718251006149 DNA binding residues [nucleotide binding] 718251006150 flagellin; Validated; Region: PRK06819 718251006151 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 718251006152 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 718251006153 flagellin; Validated; Region: PRK06819 718251006154 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 718251006155 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 718251006156 flagellar capping protein; Reviewed; Region: fliD; PRK08032 718251006157 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 718251006158 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 718251006159 flagellar protein FliS; Validated; Region: fliS; PRK05685 718251006160 Flagellar protein FliT; Region: FliT; cl05125 718251006161 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 718251006162 DNA-binding site [nucleotide binding]; DNA binding site 718251006163 RNA-binding motif; other site 718251006164 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 718251006165 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 718251006166 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 718251006167 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 718251006168 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 718251006169 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 718251006170 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 718251006171 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 718251006172 Uncharacterized conserved protein [Function unknown]; Region: COG3334 718251006173 FliG C-terminal domain; Region: FliG_C; pfam01706 718251006174 flagellar assembly protein H; Validated; Region: fliH; PRK05687 718251006175 Flagellar assembly protein FliH; Region: FliH; pfam02108 718251006176 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 718251006177 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 718251006178 Walker A motif/ATP binding site; other site 718251006179 Walker B motif; other site 718251006180 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 718251006181 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 718251006182 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 718251006183 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 718251006184 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 718251006185 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 718251006186 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 718251006187 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 718251006188 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 718251006189 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 718251006190 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 718251006191 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 718251006192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 718251006193 Peptidase M15; Region: Peptidase_M15_3; cl01194 718251006194 murein L,D-transpeptidase; Provisional; Region: PRK10594 718251006195 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 718251006196 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 718251006197 cell division protein MukB; Provisional; Region: mukB; PRK04863 718251006198 P-loop containing region of AAA domain; Region: AAA_29; cl17516 718251006199 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 718251006200 condesin subunit E; Provisional; Region: PRK05256 718251006201 condesin subunit F; Provisional; Region: PRK05260 718251006202 Methyltransferase domain; Region: Methyltransf_31; pfam13847 718251006203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251006204 S-adenosylmethionine binding site [chemical binding]; other site 718251006205 Uncharacterized conserved protein [Function unknown]; Region: COG1434 718251006206 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 718251006207 putative active site [active] 718251006208 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 718251006209 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 718251006210 active site 718251006211 putative substrate binding pocket [chemical binding]; other site 718251006212 xanthine permease; Region: pbuX; TIGR03173 718251006213 hypothetical protein; Provisional; Region: PRK10593 718251006214 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 718251006215 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 718251006216 Ligand binding site; other site 718251006217 oligomer interface; other site 718251006218 Trm112p-like protein; Region: Trm112p; cl01066 718251006219 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 718251006220 DNA-binding site [nucleotide binding]; DNA binding site 718251006221 RNA-binding motif; other site 718251006222 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 718251006223 DNA-binding site [nucleotide binding]; DNA binding site 718251006224 RNA-binding motif; other site 718251006225 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 718251006226 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 718251006227 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 718251006228 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 718251006229 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 718251006230 Walker A/P-loop; other site 718251006231 ATP binding site [chemical binding]; other site 718251006232 Q-loop/lid; other site 718251006233 ABC transporter signature motif; other site 718251006234 Walker B; other site 718251006235 D-loop; other site 718251006236 H-loop/switch region; other site 718251006237 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 718251006238 Competence protein; Region: Competence; pfam03772 718251006239 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 718251006240 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 718251006241 IHF dimer interface [polypeptide binding]; other site 718251006242 IHF - DNA interface [nucleotide binding]; other site 718251006243 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 718251006244 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 718251006245 RNA binding site [nucleotide binding]; other site 718251006246 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 718251006247 RNA binding site [nucleotide binding]; other site 718251006248 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 718251006249 RNA binding site [nucleotide binding]; other site 718251006250 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 718251006251 RNA binding site [nucleotide binding]; other site 718251006252 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 718251006253 RNA binding site [nucleotide binding]; other site 718251006254 cytidylate kinase; Provisional; Region: cmk; PRK00023 718251006255 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 718251006256 CMP-binding site; other site 718251006257 The sites determining sugar specificity; other site 718251006258 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 718251006259 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 718251006260 hinge; other site 718251006261 active site 718251006262 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 718251006263 homodimer interface [polypeptide binding]; other site 718251006264 substrate-cofactor binding pocket; other site 718251006265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251006266 catalytic residue [active] 718251006267 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 718251006268 active site 718251006269 homodimer interface [polypeptide binding]; other site 718251006270 uncharacterized domain; Region: TIGR00702 718251006271 YcaO-like family; Region: YcaO; pfam02624 718251006272 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 718251006273 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 718251006274 Pyruvate formate lyase 1; Region: PFL1; cd01678 718251006275 coenzyme A binding site [chemical binding]; other site 718251006276 active site 718251006277 catalytic residues [active] 718251006278 glycine loop; other site 718251006279 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 718251006280 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718251006281 FeS/SAM binding site; other site 718251006282 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 718251006283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718251006284 Protein of unknown function, DUF417; Region: DUF417; cl01162 718251006285 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 718251006286 catalytic residues [active] 718251006287 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 718251006288 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 718251006289 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 718251006290 putative MFS family transporter protein; Provisional; Region: PRK03633 718251006291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251006292 putative substrate translocation pore; other site 718251006293 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 718251006294 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 718251006295 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 718251006296 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 718251006297 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 718251006298 4Fe-4S binding domain; Region: Fer4; cl02805 718251006299 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718251006300 molybdopterin cofactor binding site; other site 718251006301 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 718251006302 putative molybdopterin cofactor binding site; other site 718251006303 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718251006304 seryl-tRNA synthetase; Provisional; Region: PRK05431 718251006305 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 718251006306 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 718251006307 dimer interface [polypeptide binding]; other site 718251006308 active site 718251006309 motif 1; other site 718251006310 motif 2; other site 718251006311 motif 3; other site 718251006312 recombination factor protein RarA; Reviewed; Region: PRK13342 718251006313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251006314 Walker A motif; other site 718251006315 ATP binding site [chemical binding]; other site 718251006316 Walker B motif; other site 718251006317 arginine finger; other site 718251006318 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 718251006319 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 718251006320 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 718251006321 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 718251006322 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 718251006323 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 718251006324 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 718251006325 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 718251006326 putative DNA binding site [nucleotide binding]; other site 718251006327 putative Zn2+ binding site [ion binding]; other site 718251006328 AsnC family; Region: AsnC_trans_reg; pfam01037 718251006329 thioredoxin reductase; Provisional; Region: PRK10262 718251006330 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 718251006331 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718251006332 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 718251006333 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 718251006334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251006335 Walker A/P-loop; other site 718251006336 ATP binding site [chemical binding]; other site 718251006337 Q-loop/lid; other site 718251006338 ABC transporter signature motif; other site 718251006339 Walker B; other site 718251006340 D-loop; other site 718251006341 H-loop/switch region; other site 718251006342 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 718251006343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251006344 Walker A/P-loop; other site 718251006345 ATP binding site [chemical binding]; other site 718251006346 Q-loop/lid; other site 718251006347 ABC transporter signature motif; other site 718251006348 Walker B; other site 718251006349 D-loop; other site 718251006350 H-loop/switch region; other site 718251006351 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 718251006352 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 718251006353 rRNA binding site [nucleotide binding]; other site 718251006354 predicted 30S ribosome binding site; other site 718251006355 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 718251006356 Clp amino terminal domain; Region: Clp_N; pfam02861 718251006357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251006358 Walker A motif; other site 718251006359 ATP binding site [chemical binding]; other site 718251006360 Walker B motif; other site 718251006361 arginine finger; other site 718251006362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251006363 Walker A motif; other site 718251006364 ATP binding site [chemical binding]; other site 718251006365 Walker B motif; other site 718251006366 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 718251006367 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 718251006368 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 718251006369 DNA-binding site [nucleotide binding]; DNA binding site 718251006370 RNA-binding motif; other site 718251006371 Protein of unknown function (DUF535); Region: DUF535; pfam04393 718251006372 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 718251006373 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 718251006374 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 718251006375 putative active site [active] 718251006376 putative metal-binding site [ion binding]; other site 718251006377 Predicted membrane protein [Function unknown]; Region: COG2431 718251006378 hybrid cluster protein; Provisional; Region: PRK05290 718251006379 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 718251006380 ACS interaction site; other site 718251006381 CODH interaction site; other site 718251006382 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 718251006383 hybrid metal cluster; other site 718251006384 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 718251006385 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 718251006386 FAD binding pocket [chemical binding]; other site 718251006387 FAD binding motif [chemical binding]; other site 718251006388 phosphate binding motif [ion binding]; other site 718251006389 beta-alpha-beta structure motif; other site 718251006390 NAD binding pocket [chemical binding]; other site 718251006391 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 718251006392 catalytic loop [active] 718251006393 iron binding site [ion binding]; other site 718251006394 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 718251006395 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 718251006396 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 718251006397 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 718251006398 PapC N-terminal domain; Region: PapC_N; pfam13954 718251006399 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 718251006400 PapC C-terminal domain; Region: PapC_C; pfam13953 718251006401 Fimbrial protein; Region: Fimbrial; pfam00419 718251006402 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 718251006403 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 718251006404 tetramer interface [polypeptide binding]; other site 718251006405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251006406 catalytic residue [active] 718251006407 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 718251006408 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 718251006409 putative NAD(P) binding site [chemical binding]; other site 718251006410 putative active site [active] 718251006411 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 718251006412 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 718251006413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718251006414 NAD(P) binding site [chemical binding]; other site 718251006415 active site 718251006416 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 718251006417 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 718251006418 amidase catalytic site [active] 718251006419 Zn binding residues [ion binding]; other site 718251006420 substrate binding site [chemical binding]; other site 718251006421 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 718251006422 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 718251006423 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718251006424 dimerization interface [polypeptide binding]; other site 718251006425 DNA binding residues [nucleotide binding] 718251006426 Fimbrial protein; Region: Fimbrial; cl01416 718251006427 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 718251006428 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 718251006429 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 718251006430 PapC N-terminal domain; Region: PapC_N; pfam13954 718251006431 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 718251006432 PapC C-terminal domain; Region: PapC_C; pfam13953 718251006433 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 718251006434 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 718251006435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251006436 Walker A/P-loop; other site 718251006437 ATP binding site [chemical binding]; other site 718251006438 Q-loop/lid; other site 718251006439 ABC transporter signature motif; other site 718251006440 Walker B; other site 718251006441 D-loop; other site 718251006442 H-loop/switch region; other site 718251006443 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 718251006444 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718251006445 substrate binding pocket [chemical binding]; other site 718251006446 membrane-bound complex binding site; other site 718251006447 hinge residues; other site 718251006448 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 718251006449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251006450 dimer interface [polypeptide binding]; other site 718251006451 conserved gate region; other site 718251006452 putative PBP binding loops; other site 718251006453 ABC-ATPase subunit interface; other site 718251006454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251006455 dimer interface [polypeptide binding]; other site 718251006456 conserved gate region; other site 718251006457 putative PBP binding loops; other site 718251006458 ABC-ATPase subunit interface; other site 718251006459 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 718251006460 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718251006461 substrate binding pocket [chemical binding]; other site 718251006462 membrane-bound complex binding site; other site 718251006463 hinge residues; other site 718251006464 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 718251006465 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 718251006466 DNA binding site [nucleotide binding] 718251006467 active site 718251006468 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 718251006469 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 718251006470 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 718251006471 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 718251006472 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 718251006473 dimer interface [polypeptide binding]; other site 718251006474 FMN binding site [chemical binding]; other site 718251006475 NADPH bind site [chemical binding]; other site 718251006476 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 718251006477 GSH binding site [chemical binding]; other site 718251006478 catalytic residues [active] 718251006479 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 718251006480 putative transporter; Provisional; Region: PRK04972 718251006481 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 718251006482 TrkA-C domain; Region: TrkA_C; pfam02080 718251006483 TrkA-C domain; Region: TrkA_C; pfam02080 718251006484 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 718251006485 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 718251006486 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 718251006487 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 718251006488 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 718251006489 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 718251006490 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 718251006491 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 718251006492 PapC N-terminal domain; Region: PapC_N; pfam13954 718251006493 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 718251006494 PapC C-terminal domain; Region: PapC_C; pfam13953 718251006495 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 718251006496 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 718251006497 active site 718251006498 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 718251006499 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 718251006500 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 718251006501 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718251006502 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 718251006503 serine transporter; Region: stp; TIGR00814 718251006504 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 718251006505 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 718251006506 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 718251006507 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 718251006508 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 718251006509 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 718251006510 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 718251006511 substrate binding site [chemical binding]; other site 718251006512 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 718251006513 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718251006514 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 718251006515 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 718251006516 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 718251006517 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718251006518 FeS/SAM binding site; other site 718251006519 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 718251006520 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 718251006521 putative NAD(P) binding site [chemical binding]; other site 718251006522 Peptidase family C69; Region: Peptidase_C69; pfam03577 718251006523 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 718251006524 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 718251006525 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 718251006526 histidinol dehydrogenase; Region: hisD; TIGR00069 718251006527 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 718251006528 NAD binding site [chemical binding]; other site 718251006529 dimerization interface [polypeptide binding]; other site 718251006530 product binding site; other site 718251006531 substrate binding site [chemical binding]; other site 718251006532 zinc binding site [ion binding]; other site 718251006533 catalytic residues [active] 718251006534 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 718251006535 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718251006536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251006537 homodimer interface [polypeptide binding]; other site 718251006538 catalytic residue [active] 718251006539 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 718251006540 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251006541 active site 718251006542 motif I; other site 718251006543 motif II; other site 718251006544 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 718251006545 putative active site pocket [active] 718251006546 4-fold oligomerization interface [polypeptide binding]; other site 718251006547 metal binding residues [ion binding]; metal-binding site 718251006548 3-fold/trimer interface [polypeptide binding]; other site 718251006549 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 718251006550 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 718251006551 putative active site [active] 718251006552 oxyanion strand; other site 718251006553 catalytic triad [active] 718251006554 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 718251006555 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 718251006556 catalytic residues [active] 718251006557 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 718251006558 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 718251006559 substrate binding site [chemical binding]; other site 718251006560 glutamase interaction surface [polypeptide binding]; other site 718251006561 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 718251006562 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 718251006563 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 718251006564 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 718251006565 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 718251006566 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 718251006567 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 718251006568 molybdopterin cofactor binding site [chemical binding]; other site 718251006569 substrate binding site [chemical binding]; other site 718251006570 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 718251006571 molybdopterin cofactor binding site; other site 718251006572 sugar efflux transporter B; Provisional; Region: PRK15011 718251006573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251006574 putative substrate translocation pore; other site 718251006575 Flagellin N-methylase; Region: FliB; cl00497 718251006576 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 718251006577 aromatic amino acid transport protein; Region: araaP; TIGR00837 718251006578 elongation factor P; Provisional; Region: PRK04542 718251006579 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 718251006580 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 718251006581 RNA binding site [nucleotide binding]; other site 718251006582 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 718251006583 RNA binding site [nucleotide binding]; other site 718251006584 mannonate dehydratase; Provisional; Region: PRK03906 718251006585 mannonate dehydratase; Region: uxuA; TIGR00695 718251006586 D-mannonate oxidoreductase; Provisional; Region: PRK15037 718251006587 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 718251006588 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 718251006589 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 718251006590 dimer interface [polypeptide binding]; other site 718251006591 ligand binding site [chemical binding]; other site 718251006592 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718251006593 dimerization interface [polypeptide binding]; other site 718251006594 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718251006595 dimer interface [polypeptide binding]; other site 718251006596 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 718251006597 putative CheW interface [polypeptide binding]; other site 718251006598 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 718251006599 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 718251006600 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718251006601 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 718251006602 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718251006603 DNA-binding site [nucleotide binding]; DNA binding site 718251006604 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 718251006605 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 718251006606 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 718251006607 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 718251006608 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 718251006609 NlpC/P60 family; Region: NLPC_P60; pfam00877 718251006610 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 718251006611 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 718251006612 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 718251006613 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 718251006614 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 718251006615 active site 718251006616 P-loop; other site 718251006617 phosphorylation site [posttranslational modification] 718251006618 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 718251006619 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 718251006620 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 718251006621 putative substrate binding site [chemical binding]; other site 718251006622 putative ATP binding site [chemical binding]; other site 718251006623 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 718251006624 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 718251006625 active site 718251006626 phosphorylation site [posttranslational modification] 718251006627 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 718251006628 dimerization domain swap beta strand [polypeptide binding]; other site 718251006629 regulatory protein interface [polypeptide binding]; other site 718251006630 active site 718251006631 regulatory phosphorylation site [posttranslational modification]; other site 718251006632 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 718251006633 nudix motif; other site 718251006634 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 718251006635 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718251006636 substrate binding pocket [chemical binding]; other site 718251006637 membrane-bound complex binding site; other site 718251006638 hinge residues; other site 718251006639 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 718251006640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251006641 dimer interface [polypeptide binding]; other site 718251006642 conserved gate region; other site 718251006643 putative PBP binding loops; other site 718251006644 ABC-ATPase subunit interface; other site 718251006645 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 718251006646 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 718251006647 Walker A/P-loop; other site 718251006648 ATP binding site [chemical binding]; other site 718251006649 Q-loop/lid; other site 718251006650 ABC transporter signature motif; other site 718251006651 Walker B; other site 718251006652 D-loop; other site 718251006653 H-loop/switch region; other site 718251006654 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 718251006655 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 718251006656 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 718251006657 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 718251006658 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 718251006659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251006660 putative substrate translocation pore; other site 718251006661 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 718251006662 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718251006663 RNA binding surface [nucleotide binding]; other site 718251006664 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 718251006665 active site 718251006666 uracil binding [chemical binding]; other site 718251006667 probable metal-binding protein; Region: matur_matur; TIGR03853 718251006668 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 718251006669 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718251006670 ATP binding site [chemical binding]; other site 718251006671 putative Mg++ binding site [ion binding]; other site 718251006672 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718251006673 nucleotide binding region [chemical binding]; other site 718251006674 ATP-binding site [chemical binding]; other site 718251006675 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 718251006676 5S rRNA interface [nucleotide binding]; other site 718251006677 CTC domain interface [polypeptide binding]; other site 718251006678 L16 interface [polypeptide binding]; other site 718251006679 nucleoid-associated protein NdpA; Validated; Region: PRK00378 718251006680 Nucleoid-associated protein [General function prediction only]; Region: COG3081 718251006681 hypothetical protein; Provisional; Region: PRK13689 718251006682 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 718251006683 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 718251006684 Sulfatase; Region: Sulfatase; cl17466 718251006685 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 718251006686 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718251006687 metal binding site [ion binding]; metal-binding site 718251006688 active site 718251006689 I-site; other site 718251006690 enolase; Provisional; Region: eno; PRK00077 718251006691 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 718251006692 dimer interface [polypeptide binding]; other site 718251006693 metal binding site [ion binding]; metal-binding site 718251006694 substrate binding pocket [chemical binding]; other site 718251006695 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 718251006696 Ligand Binding Site [chemical binding]; other site 718251006697 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 718251006698 DHH family; Region: DHH; pfam01368 718251006699 DHHA2 domain; Region: DHHA2; pfam02833 718251006700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718251006701 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 718251006702 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 718251006703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718251006704 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 718251006705 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 718251006706 ATP binding site [chemical binding]; other site 718251006707 Mg++ binding site [ion binding]; other site 718251006708 motif III; other site 718251006709 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718251006710 nucleotide binding region [chemical binding]; other site 718251006711 ATP-binding site [chemical binding]; other site 718251006712 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 718251006713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718251006714 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 718251006715 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 718251006716 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718251006717 HlyD family secretion protein; Region: HlyD_3; pfam13437 718251006718 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 718251006719 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 718251006720 Walker A/P-loop; other site 718251006721 ATP binding site [chemical binding]; other site 718251006722 Q-loop/lid; other site 718251006723 ABC transporter signature motif; other site 718251006724 Walker B; other site 718251006725 D-loop; other site 718251006726 H-loop/switch region; other site 718251006727 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 718251006728 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 718251006729 Walker A/P-loop; other site 718251006730 ATP binding site [chemical binding]; other site 718251006731 Q-loop/lid; other site 718251006732 ABC transporter signature motif; other site 718251006733 Walker B; other site 718251006734 D-loop; other site 718251006735 H-loop/switch region; other site 718251006736 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 718251006737 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 718251006738 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 718251006739 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 718251006740 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 718251006741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251006742 ATP binding site [chemical binding]; other site 718251006743 Mg2+ binding site [ion binding]; other site 718251006744 G-X-G motif; other site 718251006745 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 718251006746 putative binding surface; other site 718251006747 active site 718251006748 transcriptional regulator RcsB; Provisional; Region: PRK10840 718251006749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251006750 active site 718251006751 phosphorylation site [posttranslational modification] 718251006752 intermolecular recognition site; other site 718251006753 dimerization interface [polypeptide binding]; other site 718251006754 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718251006755 DNA binding residues [nucleotide binding] 718251006756 dimerization interface [polypeptide binding]; other site 718251006757 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 718251006758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251006759 dimer interface [polypeptide binding]; other site 718251006760 phosphorylation site [posttranslational modification] 718251006761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251006762 ATP binding site [chemical binding]; other site 718251006763 Mg2+ binding site [ion binding]; other site 718251006764 G-X-G motif; other site 718251006765 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 718251006766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251006767 active site 718251006768 phosphorylation site [posttranslational modification] 718251006769 intermolecular recognition site; other site 718251006770 dimerization interface [polypeptide binding]; other site 718251006771 DNA gyrase subunit A; Validated; Region: PRK05560 718251006772 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 718251006773 CAP-like domain; other site 718251006774 active site 718251006775 primary dimer interface [polypeptide binding]; other site 718251006776 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718251006777 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718251006778 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718251006779 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718251006780 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718251006781 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 718251006782 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 718251006783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251006784 S-adenosylmethionine binding site [chemical binding]; other site 718251006785 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 718251006786 ATP cone domain; Region: ATP-cone; pfam03477 718251006787 Class I ribonucleotide reductase; Region: RNR_I; cd01679 718251006788 active site 718251006789 dimer interface [polypeptide binding]; other site 718251006790 catalytic residues [active] 718251006791 effector binding site; other site 718251006792 R2 peptide binding site; other site 718251006793 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 718251006794 dimer interface [polypeptide binding]; other site 718251006795 putative radical transfer pathway; other site 718251006796 diiron center [ion binding]; other site 718251006797 tyrosyl radical; other site 718251006798 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 718251006799 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 718251006800 catalytic loop [active] 718251006801 iron binding site [ion binding]; other site 718251006802 putative oxidoreductase; Provisional; Region: PRK09939 718251006803 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 718251006804 putative molybdopterin cofactor binding site [chemical binding]; other site 718251006805 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 718251006806 putative molybdopterin cofactor binding site; other site 718251006807 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 718251006808 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 718251006809 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 718251006810 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 718251006811 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 718251006812 MoaE homodimer interface [polypeptide binding]; other site 718251006813 MoaD interaction [polypeptide binding]; other site 718251006814 active site residues [active] 718251006815 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 718251006816 MoaE interaction surface [polypeptide binding]; other site 718251006817 MoeB interaction surface [polypeptide binding]; other site 718251006818 thiocarboxylated glycine; other site 718251006819 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 718251006820 trimer interface [polypeptide binding]; other site 718251006821 dimer interface [polypeptide binding]; other site 718251006822 putative active site [active] 718251006823 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 718251006824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718251006825 FeS/SAM binding site; other site 718251006826 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 718251006827 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 718251006828 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 718251006829 phosphate binding site [ion binding]; other site 718251006830 putative substrate binding pocket [chemical binding]; other site 718251006831 dimer interface [polypeptide binding]; other site 718251006832 hypothetical protein; Provisional; Region: PRK03673 718251006833 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 718251006834 putative MPT binding site; other site 718251006835 tyrosine transporter TyrP; Provisional; Region: PRK15132 718251006836 aromatic amino acid transport protein; Region: araaP; TIGR00837 718251006837 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 718251006838 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 718251006839 active site 718251006840 HIGH motif; other site 718251006841 dimer interface [polypeptide binding]; other site 718251006842 KMSKS motif; other site 718251006843 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 718251006844 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 718251006845 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 718251006846 acyl-activating enzyme (AAE) consensus motif; other site 718251006847 AMP binding site [chemical binding]; other site 718251006848 active site 718251006849 CoA binding site [chemical binding]; other site 718251006850 O-succinylbenzoate synthase; Provisional; Region: PRK05105 718251006851 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 718251006852 active site 718251006853 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 718251006854 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 718251006855 substrate binding site [chemical binding]; other site 718251006856 oxyanion hole (OAH) forming residues; other site 718251006857 trimer interface [polypeptide binding]; other site 718251006858 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 718251006859 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 718251006860 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 718251006861 dimer interface [polypeptide binding]; other site 718251006862 tetramer interface [polypeptide binding]; other site 718251006863 PYR/PP interface [polypeptide binding]; other site 718251006864 TPP binding site [chemical binding]; other site 718251006865 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 718251006866 TPP-binding site; other site 718251006867 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 718251006868 chorismate binding enzyme; Region: Chorismate_bind; cl10555 718251006869 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 718251006870 Peptidase family C69; Region: Peptidase_C69; pfam03577 718251006871 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 718251006872 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 718251006873 nickel binding site [ion binding]; other site 718251006874 putative substrate-binding site; other site 718251006875 hydrogenase 2 large subunit; Provisional; Region: PRK10467 718251006876 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 718251006877 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 718251006878 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 718251006879 4Fe-4S binding domain; Region: Fer4_6; pfam12837 718251006880 hydrogenase 2 small subunit; Provisional; Region: PRK10468 718251006881 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 718251006882 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 718251006883 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 718251006884 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 718251006885 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 718251006886 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 718251006887 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 718251006888 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 718251006889 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 718251006890 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 718251006891 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 718251006892 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 718251006893 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 718251006894 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 718251006895 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 718251006896 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 718251006897 4Fe-4S binding domain; Region: Fer4; pfam00037 718251006898 4Fe-4S binding domain; Region: Fer4; pfam00037 718251006899 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 718251006900 NADH dehydrogenase subunit G; Validated; Region: PRK08166 718251006901 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 718251006902 catalytic loop [active] 718251006903 iron binding site [ion binding]; other site 718251006904 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 718251006905 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 718251006906 [4Fe-4S] binding site [ion binding]; other site 718251006907 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 718251006908 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 718251006909 SLBB domain; Region: SLBB; pfam10531 718251006910 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 718251006911 NADH dehydrogenase subunit E; Validated; Region: PRK07539 718251006912 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 718251006913 putative dimer interface [polypeptide binding]; other site 718251006914 [2Fe-2S] cluster binding site [ion binding]; other site 718251006915 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 718251006916 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 718251006917 NADH dehydrogenase subunit D; Validated; Region: PRK06075 718251006918 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 718251006919 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 718251006920 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 718251006921 putative dimerization interface [polypeptide binding]; other site 718251006922 Uncharacterized conserved protein [Function unknown]; Region: COG0398 718251006923 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 718251006924 Rhodanese Homology Domain; Region: RHOD; smart00450 718251006925 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 718251006926 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 718251006927 active site residue [active] 718251006928 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 718251006929 active site residue [active] 718251006930 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 718251006931 Uncharacterized conserved protein [Function unknown]; Region: COG2128 718251006932 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 718251006933 aminotransferase AlaT; Validated; Region: PRK09265 718251006934 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718251006935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251006936 homodimer interface [polypeptide binding]; other site 718251006937 catalytic residue [active] 718251006938 5'-nucleotidase; Provisional; Region: PRK03826 718251006939 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 718251006940 TrkA-C domain; Region: TrkA_C; pfam02080 718251006941 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 718251006942 TrkA-C domain; Region: TrkA_C; pfam02080 718251006943 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 718251006944 putative phosphatase; Provisional; Region: PRK11587 718251006945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251006946 active site 718251006947 motif I; other site 718251006948 motif II; other site 718251006949 hypothetical protein; Validated; Region: PRK05445 718251006950 hypothetical protein; Provisional; Region: PRK01816 718251006951 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 718251006952 propionate/acetate kinase; Provisional; Region: PRK12379 718251006953 phosphate acetyltransferase; Reviewed; Region: PRK05632 718251006954 DRTGG domain; Region: DRTGG; pfam07085 718251006955 phosphate acetyltransferase; Region: pta; TIGR00651 718251006956 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 718251006957 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 718251006958 active site residue [active] 718251006959 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 718251006960 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 718251006961 nudix motif; other site 718251006962 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 718251006963 active site 718251006964 metal binding site [ion binding]; metal-binding site 718251006965 homotetramer interface [polypeptide binding]; other site 718251006966 glutathione S-transferase; Provisional; Region: PRK15113 718251006967 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 718251006968 C-terminal domain interface [polypeptide binding]; other site 718251006969 GSH binding site (G-site) [chemical binding]; other site 718251006970 dimer interface [polypeptide binding]; other site 718251006971 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 718251006972 N-terminal domain interface [polypeptide binding]; other site 718251006973 putative dimer interface [polypeptide binding]; other site 718251006974 putative substrate binding pocket (H-site) [chemical binding]; other site 718251006975 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 718251006976 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 718251006977 C-terminal domain interface [polypeptide binding]; other site 718251006978 GSH binding site (G-site) [chemical binding]; other site 718251006979 dimer interface [polypeptide binding]; other site 718251006980 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 718251006981 N-terminal domain interface [polypeptide binding]; other site 718251006982 putative dimer interface [polypeptide binding]; other site 718251006983 active site 718251006984 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 718251006985 homooctamer interface [polypeptide binding]; other site 718251006986 active site 718251006987 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 718251006988 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 718251006989 putative NAD(P) binding site [chemical binding]; other site 718251006990 putative active site [active] 718251006991 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 718251006992 classical (c) SDRs; Region: SDR_c; cd05233 718251006993 NAD(P) binding site [chemical binding]; other site 718251006994 active site 718251006995 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 718251006996 Flavoprotein; Region: Flavoprotein; pfam02441 718251006997 amidophosphoribosyltransferase; Provisional; Region: PRK09246 718251006998 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 718251006999 active site 718251007000 tetramer interface [polypeptide binding]; other site 718251007001 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718251007002 active site 718251007003 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 718251007004 colicin V production protein; Provisional; Region: PRK10845 718251007005 cell division protein DedD; Provisional; Region: PRK11633 718251007006 Sporulation related domain; Region: SPOR; pfam05036 718251007007 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 718251007008 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 718251007009 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 718251007010 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 718251007011 hypothetical protein; Provisional; Region: PRK10847 718251007012 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 718251007013 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 718251007014 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 718251007015 dimerization interface 3.5A [polypeptide binding]; other site 718251007016 active site 718251007017 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 718251007018 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 718251007019 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 718251007020 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 718251007021 ligand binding site [chemical binding]; other site 718251007022 NAD binding site [chemical binding]; other site 718251007023 catalytic site [active] 718251007024 homodimer interface [polypeptide binding]; other site 718251007025 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 718251007026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 718251007027 Methyltransferase domain; Region: Methyltransf_31; pfam13847 718251007028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251007029 S-adenosylmethionine binding site [chemical binding]; other site 718251007030 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 718251007031 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 718251007032 dimer interface [polypeptide binding]; other site 718251007033 active site 718251007034 Uncharacterized conserved protein [Function unknown]; Region: COG4121 718251007035 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 718251007036 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 718251007037 YfcL protein; Region: YfcL; pfam08891 718251007038 Protein of unknown function, DUF462; Region: DUF462; cl01190 718251007039 hypothetical protein; Provisional; Region: PRK10621 718251007040 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 718251007041 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 718251007042 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 718251007043 NlpC/P60 family; Region: NLPC_P60; cl17555 718251007044 Protein of unknown function (DUF770); Region: DUF770; pfam05591 718251007045 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 718251007046 Protein of unknown function (DUF877); Region: DUF877; pfam05943 718251007047 Protein of unknown function (DUF796); Region: DUF796; pfam05638 718251007048 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 718251007049 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 718251007050 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 718251007051 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 718251007052 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 718251007053 Clp amino terminal domain; Region: Clp_N; pfam02861 718251007054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251007055 Walker A motif; other site 718251007056 ATP binding site [chemical binding]; other site 718251007057 Walker B motif; other site 718251007058 arginine finger; other site 718251007059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251007060 ATP binding site [chemical binding]; other site 718251007061 Walker B motif; other site 718251007062 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 718251007063 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 718251007064 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 718251007065 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 718251007066 PAAR motif; Region: PAAR_motif; cl15808 718251007067 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 718251007068 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 718251007069 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 718251007070 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 718251007071 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 718251007072 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 718251007073 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 718251007074 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 718251007075 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 718251007076 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 718251007077 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 718251007078 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 718251007079 Tetramer interface [polypeptide binding]; other site 718251007080 active site 718251007081 FMN-binding site [chemical binding]; other site 718251007082 HemK family putative methylases; Region: hemK_fam; TIGR00536 718251007083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251007084 S-adenosylmethionine binding site [chemical binding]; other site 718251007085 hypothetical protein; Provisional; Region: PRK04946 718251007086 Smr domain; Region: Smr; pfam01713 718251007087 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 718251007088 catalytic core [active] 718251007089 Protein of unknown function (DUF406); Region: DUF406; pfam04175 718251007090 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 718251007091 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 718251007092 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 718251007093 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 718251007094 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 718251007095 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 718251007096 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 718251007097 catalytic residues [active] 718251007098 central insert; other site 718251007099 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 718251007100 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 718251007101 Heme exporter protein D (CcmD); Region: CcmD; cl11475 718251007102 heme exporter protein CcmC; Region: ccmC; TIGR01191 718251007103 heme exporter protein CcmB; Region: ccmB; TIGR01190 718251007104 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 718251007105 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 718251007106 Walker A/P-loop; other site 718251007107 ATP binding site [chemical binding]; other site 718251007108 Q-loop/lid; other site 718251007109 ABC transporter signature motif; other site 718251007110 Walker B; other site 718251007111 D-loop; other site 718251007112 H-loop/switch region; other site 718251007113 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 718251007114 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718251007115 HlyD family secretion protein; Region: HlyD_3; pfam13437 718251007116 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 718251007117 Part of AAA domain; Region: AAA_19; pfam13245 718251007118 AAA domain; Region: AAA_12; pfam13087 718251007119 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 718251007120 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 718251007121 transcriptional regulator protein; Region: phnR; TIGR03337 718251007122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718251007123 DNA-binding site [nucleotide binding]; DNA binding site 718251007124 UTRA domain; Region: UTRA; cl17743 718251007125 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 718251007126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251007127 putative substrate translocation pore; other site 718251007128 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 718251007129 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718251007130 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251007131 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718251007132 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 718251007133 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 718251007134 4Fe-4S binding domain; Region: Fer4; pfam00037 718251007135 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 718251007136 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 718251007137 dimer interface [polypeptide binding]; other site 718251007138 PYR/PP interface [polypeptide binding]; other site 718251007139 TPP binding site [chemical binding]; other site 718251007140 substrate binding site [chemical binding]; other site 718251007141 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 718251007142 Domain of unknown function; Region: EKR; pfam10371 718251007143 4Fe-4S binding domain; Region: Fer4_6; pfam12837 718251007144 4Fe-4S binding domain; Region: Fer4; pfam00037 718251007145 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 718251007146 TPP-binding site [chemical binding]; other site 718251007147 dimer interface [polypeptide binding]; other site 718251007148 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 718251007149 active site residue [active] 718251007150 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 718251007151 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 718251007152 dimerization interface [polypeptide binding]; other site 718251007153 putative DNA binding site [nucleotide binding]; other site 718251007154 putative Zn2+ binding site [ion binding]; other site 718251007155 Transglycosylase SLT domain; Region: SLT_2; pfam13406 718251007156 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 718251007157 N-acetyl-D-glucosamine binding site [chemical binding]; other site 718251007158 catalytic residue [active] 718251007159 carbon starvation protein A; Provisional; Region: PRK15015 718251007160 Carbon starvation protein CstA; Region: CstA; pfam02554 718251007161 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 718251007162 Uncharacterized small protein [Function unknown]; Region: COG2879 718251007163 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 718251007164 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718251007165 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 718251007166 leucine export protein LeuE; Provisional; Region: PRK10958 718251007167 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 718251007168 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718251007169 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718251007170 Serine protease inhibitor ecotin [General function prediction only]; Region: Eco; COG4574 718251007171 secondary substrate binding site; other site 718251007172 primary substrate binding site; other site 718251007173 inhibition loop; other site 718251007174 dimerization interface [polypeptide binding]; other site 718251007175 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 718251007176 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718251007177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251007178 Walker A/P-loop; other site 718251007179 ATP binding site [chemical binding]; other site 718251007180 ABC transporter signature motif; other site 718251007181 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718251007182 Walker B; other site 718251007183 ABC transporter; Region: ABC_tran_2; pfam12848 718251007184 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718251007185 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 718251007186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251007187 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718251007188 dimerization interface [polypeptide binding]; other site 718251007189 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 718251007190 HAMP domain; Region: HAMP; pfam00672 718251007191 dimerization interface [polypeptide binding]; other site 718251007192 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718251007193 dimer interface [polypeptide binding]; other site 718251007194 putative CheW interface [polypeptide binding]; other site 718251007195 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 718251007196 active site 718251007197 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 718251007198 DJ-1 family protein; Region: not_thiJ; TIGR01383 718251007199 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 718251007200 conserved cys residue [active] 718251007201 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 718251007202 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 718251007203 intersubunit interface [polypeptide binding]; other site 718251007204 active site 718251007205 zinc binding site [ion binding]; other site 718251007206 Na+ binding site [ion binding]; other site 718251007207 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 718251007208 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 718251007209 Sulfatase; Region: Sulfatase; pfam00884 718251007210 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 718251007211 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718251007212 FeS/SAM binding site; other site 718251007213 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 718251007214 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 718251007215 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 718251007216 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 718251007217 active site 718251007218 dimer interface [polypeptide binding]; other site 718251007219 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 718251007220 active pocket/dimerization site; other site 718251007221 active site 718251007222 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 718251007223 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 718251007224 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 718251007225 active site 718251007226 phosphorylation site [posttranslational modification] 718251007227 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 718251007228 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 718251007229 dimer interface [polypeptide binding]; other site 718251007230 active site 718251007231 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 718251007232 putative active site [active] 718251007233 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 718251007234 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 718251007235 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 718251007236 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718251007237 Protein of unknown function (DUF808); Region: DUF808; pfam05661 718251007238 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 718251007239 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 718251007240 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 718251007241 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 718251007242 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 718251007243 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 718251007244 FMN binding site [chemical binding]; other site 718251007245 active site 718251007246 catalytic residues [active] 718251007247 substrate binding site [chemical binding]; other site 718251007248 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 718251007249 excinuclease ABC subunit B; Provisional; Region: PRK05298 718251007250 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718251007251 ATP binding site [chemical binding]; other site 718251007252 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718251007253 nucleotide binding region [chemical binding]; other site 718251007254 ATP-binding site [chemical binding]; other site 718251007255 Ultra-violet resistance protein B; Region: UvrB; pfam12344 718251007256 UvrB/uvrC motif; Region: UVR; pfam02151 718251007257 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 718251007258 AAA domain; Region: AAA_26; pfam13500 718251007259 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 718251007260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251007261 S-adenosylmethionine binding site [chemical binding]; other site 718251007262 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 718251007263 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 718251007264 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718251007265 catalytic residue [active] 718251007266 biotin synthase; Provisional; Region: PRK15108 718251007267 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718251007268 FeS/SAM binding site; other site 718251007269 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 718251007270 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 718251007271 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 718251007272 inhibitor-cofactor binding pocket; inhibition site 718251007273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251007274 catalytic residue [active] 718251007275 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 718251007276 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 718251007277 active site 718251007278 motif I; other site 718251007279 motif II; other site 718251007280 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251007281 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 718251007282 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251007283 Walker A/P-loop; other site 718251007284 ATP binding site [chemical binding]; other site 718251007285 Q-loop/lid; other site 718251007286 ABC transporter signature motif; other site 718251007287 Walker B; other site 718251007288 D-loop; other site 718251007289 H-loop/switch region; other site 718251007290 TOBE domain; Region: TOBE; cl01440 718251007291 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 718251007292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251007293 dimer interface [polypeptide binding]; other site 718251007294 conserved gate region; other site 718251007295 putative PBP binding loops; other site 718251007296 ABC-ATPase subunit interface; other site 718251007297 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 718251007298 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 718251007299 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 718251007300 putative active site [active] 718251007301 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 718251007302 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 718251007303 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 718251007304 molybdenum-pterin binding domain; Region: Mop; TIGR00638 718251007305 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 718251007306 CAAX protease self-immunity; Region: Abi; pfam02517 718251007307 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 718251007308 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 718251007309 NAD binding site [chemical binding]; other site 718251007310 homodimer interface [polypeptide binding]; other site 718251007311 active site 718251007312 substrate binding site [chemical binding]; other site 718251007313 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 718251007314 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 718251007315 dimer interface [polypeptide binding]; other site 718251007316 active site 718251007317 galactokinase; Provisional; Region: PRK05101 718251007318 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 718251007319 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 718251007320 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 718251007321 active site 718251007322 catalytic residues [active] 718251007323 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 718251007324 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 718251007325 transmembrane helices; other site 718251007326 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 718251007327 catalytic core [active] 718251007328 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 718251007329 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 718251007330 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 718251007331 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 718251007332 Tetratricopeptide repeat; Region: TPR_6; pfam13174 718251007333 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 718251007334 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 718251007335 ligand binding site [chemical binding]; other site 718251007336 translocation protein TolB; Provisional; Region: tolB; PRK03629 718251007337 TolB amino-terminal domain; Region: TolB_N; pfam04052 718251007338 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 718251007339 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 718251007340 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 718251007341 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 718251007342 TolA C-terminal; Region: TolA; pfam06519 718251007343 colicin uptake protein TolR; Provisional; Region: PRK11024 718251007344 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 718251007345 colicin uptake protein TolQ; Provisional; Region: PRK10801 718251007346 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 718251007347 active site 718251007348 hypothetical protein; Provisional; Region: PRK10588 718251007349 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 718251007350 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 718251007351 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 718251007352 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 718251007353 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 718251007354 CoA binding domain; Region: CoA_binding; pfam02629 718251007355 CoA-ligase; Region: Ligase_CoA; pfam00549 718251007356 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 718251007357 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 718251007358 CoA-ligase; Region: Ligase_CoA; pfam00549 718251007359 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 718251007360 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 718251007361 E3 interaction surface; other site 718251007362 lipoyl attachment site [posttranslational modification]; other site 718251007363 e3 binding domain; Region: E3_binding; pfam02817 718251007364 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 718251007365 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 718251007366 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 718251007367 TPP-binding site [chemical binding]; other site 718251007368 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 718251007369 PYR/PP interface [polypeptide binding]; other site 718251007370 dimer interface [polypeptide binding]; other site 718251007371 TPP binding site [chemical binding]; other site 718251007372 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 718251007373 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 718251007374 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 718251007375 L-aspartate oxidase; Provisional; Region: PRK06175 718251007376 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 718251007377 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 718251007378 SdhC subunit interface [polypeptide binding]; other site 718251007379 proximal heme binding site [chemical binding]; other site 718251007380 cardiolipin binding site; other site 718251007381 Iron-sulfur protein interface; other site 718251007382 proximal quinone binding site [chemical binding]; other site 718251007383 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 718251007384 Iron-sulfur protein interface; other site 718251007385 proximal quinone binding site [chemical binding]; other site 718251007386 SdhD (CybS) interface [polypeptide binding]; other site 718251007387 proximal heme binding site [chemical binding]; other site 718251007388 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 718251007389 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 718251007390 dimer interface [polypeptide binding]; other site 718251007391 active site 718251007392 citrylCoA binding site [chemical binding]; other site 718251007393 NADH binding [chemical binding]; other site 718251007394 cationic pore residues; other site 718251007395 oxalacetate/citrate binding site [chemical binding]; other site 718251007396 coenzyme A binding site [chemical binding]; other site 718251007397 catalytic triad [active] 718251007398 endonuclease VIII; Provisional; Region: PRK10445 718251007399 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 718251007400 DNA binding site [nucleotide binding] 718251007401 catalytic residue [active] 718251007402 putative catalytic residues [active] 718251007403 H2TH interface [polypeptide binding]; other site 718251007404 intercalation triad [nucleotide binding]; other site 718251007405 substrate specificity determining residue; other site 718251007406 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 718251007407 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 718251007408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 718251007409 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 718251007410 hypothetical protein; Provisional; Region: PRK10220 718251007411 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 718251007412 PhnA protein; Region: PhnA; pfam03831 718251007413 Autoinducer binding domain; Region: Autoind_bind; pfam03472 718251007414 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718251007415 DNA binding residues [nucleotide binding] 718251007416 dimerization interface [polypeptide binding]; other site 718251007417 Autoinducer synthetase; Region: Autoind_synth; pfam00765 718251007418 Uncharacterized conserved protein [Function unknown]; Region: COG0327 718251007419 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 718251007420 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 718251007421 DNA photolyase; Region: DNA_photolyase; pfam00875 718251007422 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 718251007423 Protein of unknown function (DUF523); Region: DUF523; pfam04463 718251007424 Uncharacterized conserved protein [Function unknown]; Region: COG3272 718251007425 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 718251007426 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 718251007427 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 718251007428 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 718251007429 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 718251007430 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 718251007431 sensor protein KdpD; Provisional; Region: PRK10490 718251007432 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 718251007433 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 718251007434 Ligand Binding Site [chemical binding]; other site 718251007435 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 718251007436 GAF domain; Region: GAF_3; pfam13492 718251007437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251007438 dimer interface [polypeptide binding]; other site 718251007439 phosphorylation site [posttranslational modification] 718251007440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251007441 ATP binding site [chemical binding]; other site 718251007442 Mg2+ binding site [ion binding]; other site 718251007443 G-X-G motif; other site 718251007444 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 718251007445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251007446 active site 718251007447 phosphorylation site [posttranslational modification] 718251007448 intermolecular recognition site; other site 718251007449 dimerization interface [polypeptide binding]; other site 718251007450 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718251007451 DNA binding site [nucleotide binding] 718251007452 phosphoglucomutase; Validated; Region: PRK07564 718251007453 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 718251007454 active site 718251007455 substrate binding site [chemical binding]; other site 718251007456 metal binding site [ion binding]; metal-binding site 718251007457 replication initiation regulator SeqA; Provisional; Region: PRK11187 718251007458 acyl-CoA esterase; Provisional; Region: PRK10673 718251007459 PGAP1-like protein; Region: PGAP1; pfam07819 718251007460 LexA regulated protein; Provisional; Region: PRK11675 718251007461 flavodoxin FldA; Validated; Region: PRK09267 718251007462 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 718251007463 putative DNA binding helix; other site 718251007464 metal binding site 2 [ion binding]; metal-binding site 718251007465 metal binding site 1 [ion binding]; metal-binding site 718251007466 dimer interface [polypeptide binding]; other site 718251007467 structural Zn2+ binding site [ion binding]; other site 718251007468 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 718251007469 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 718251007470 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 718251007471 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 718251007472 active site 718251007473 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 718251007474 YbfN-like lipoprotein; Region: YbfN; pfam13982 718251007475 outer membrane porin, OprD family; Region: OprD; pfam03573 718251007476 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 718251007477 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 718251007478 active site 718251007479 HIGH motif; other site 718251007480 nucleotide binding site [chemical binding]; other site 718251007481 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 718251007482 KMSKS motif; other site 718251007483 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 718251007484 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 718251007485 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 718251007486 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 718251007487 active site turn [active] 718251007488 phosphorylation site [posttranslational modification] 718251007489 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 718251007490 HPr interaction site; other site 718251007491 glycerol kinase (GK) interaction site [polypeptide binding]; other site 718251007492 active site 718251007493 phosphorylation site [posttranslational modification] 718251007494 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 718251007495 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 718251007496 active site 718251007497 trimer interface [polypeptide binding]; other site 718251007498 allosteric site; other site 718251007499 active site lid [active] 718251007500 hexamer (dimer of trimers) interface [polypeptide binding]; other site 718251007501 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 718251007502 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 718251007503 active site 718251007504 dimer interface [polypeptide binding]; other site 718251007505 MarR family; Region: MarR; pfam01047 718251007506 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 718251007507 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 718251007508 nucleotide binding site [chemical binding]; other site 718251007509 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 718251007510 UMP phosphatase; Provisional; Region: PRK10444 718251007511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251007512 active site 718251007513 motif I; other site 718251007514 motif II; other site 718251007515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251007516 asparagine synthetase B; Provisional; Region: asnB; PRK09431 718251007517 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 718251007518 active site 718251007519 dimer interface [polypeptide binding]; other site 718251007520 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 718251007521 Ligand Binding Site [chemical binding]; other site 718251007522 Molecular Tunnel; other site 718251007523 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 718251007524 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 718251007525 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 718251007526 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 718251007527 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718251007528 FeS/SAM binding site; other site 718251007529 TRAM domain; Region: TRAM; pfam01938 718251007530 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 718251007531 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 718251007532 PhoH-like protein; Region: PhoH; pfam02562 718251007533 metal-binding heat shock protein; Provisional; Region: PRK00016 718251007534 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 718251007535 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 718251007536 Transporter associated domain; Region: CorC_HlyC; smart01091 718251007537 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 718251007538 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 718251007539 putative active site [active] 718251007540 catalytic triad [active] 718251007541 putative dimer interface [polypeptide binding]; other site 718251007542 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 718251007543 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718251007544 substrate binding pocket [chemical binding]; other site 718251007545 membrane-bound complex binding site; other site 718251007546 hinge residues; other site 718251007547 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 718251007548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251007549 dimer interface [polypeptide binding]; other site 718251007550 conserved gate region; other site 718251007551 putative PBP binding loops; other site 718251007552 ABC-ATPase subunit interface; other site 718251007553 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 718251007554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251007555 dimer interface [polypeptide binding]; other site 718251007556 conserved gate region; other site 718251007557 putative PBP binding loops; other site 718251007558 ABC-ATPase subunit interface; other site 718251007559 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 718251007560 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 718251007561 Walker A/P-loop; other site 718251007562 ATP binding site [chemical binding]; other site 718251007563 Q-loop/lid; other site 718251007564 ABC transporter signature motif; other site 718251007565 Walker B; other site 718251007566 D-loop; other site 718251007567 H-loop/switch region; other site 718251007568 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 718251007569 active site 718251007570 tetramer interface [polypeptide binding]; other site 718251007571 hypothetical protein; Provisional; Region: PRK11032 718251007572 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 718251007573 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 718251007574 HIGH motif; other site 718251007575 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 718251007576 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 718251007577 active site 718251007578 KMSKS motif; other site 718251007579 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 718251007580 tRNA binding surface [nucleotide binding]; other site 718251007581 Lipopolysaccharide-assembly; Region: LptE; cl01125 718251007582 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 718251007583 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 718251007584 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 718251007585 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 718251007586 active site 718251007587 (T/H)XGH motif; other site 718251007588 ribosome-associated protein; Provisional; Region: PRK11538 718251007589 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 718251007590 penicillin-binding protein 2; Provisional; Region: PRK10795 718251007591 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 718251007592 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 718251007593 cell wall shape-determining protein; Provisional; Region: PRK10794 718251007594 rare lipoprotein A; Provisional; Region: PRK10672 718251007595 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 718251007596 Sporulation related domain; Region: SPOR; pfam05036 718251007597 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 718251007598 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 718251007599 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 718251007600 hypothetical protein; Provisional; Region: PRK04998 718251007601 lipoate-protein ligase B; Provisional; Region: PRK14342 718251007602 lipoyl synthase; Provisional; Region: PRK05481 718251007603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718251007604 FeS/SAM binding site; other site 718251007605 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 718251007606 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 718251007607 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 718251007608 active site 718251007609 catalytic tetrad [active] 718251007610 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 718251007611 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 718251007612 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 718251007613 N-acetyl-D-glucosamine binding site [chemical binding]; other site 718251007614 catalytic residue [active] 718251007615 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 718251007616 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 718251007617 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 718251007618 acyl-activating enzyme (AAE) consensus motif; other site 718251007619 putative AMP binding site [chemical binding]; other site 718251007620 putative active site [active] 718251007621 putative CoA binding site [chemical binding]; other site 718251007622 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 718251007623 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 718251007624 substrate binding site [chemical binding]; other site 718251007625 oxyanion hole (OAH) forming residues; other site 718251007626 trimer interface [polypeptide binding]; other site 718251007627 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 718251007628 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 718251007629 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 718251007630 acyl-activating enzyme (AAE) consensus motif; other site 718251007631 putative AMP binding site [chemical binding]; other site 718251007632 putative active site [active] 718251007633 putative CoA binding site [chemical binding]; other site 718251007634 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 718251007635 CoA-transferase family III; Region: CoA_transf_3; pfam02515 718251007636 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 718251007637 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 718251007638 active site 718251007639 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 718251007640 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 718251007641 Ligand binding site [chemical binding]; other site 718251007642 Electron transfer flavoprotein domain; Region: ETF; pfam01012 718251007643 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 718251007644 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 718251007645 putative oxidoreductase FixC; Provisional; Region: PRK10157 718251007646 ferredoxin-like protein FixX; Provisional; Region: PRK15449 718251007647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251007648 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 718251007649 putative substrate translocation pore; other site 718251007650 acetyl esterase; Provisional; Region: PRK10162 718251007651 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 718251007652 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 718251007653 Methyltransferase domain; Region: Methyltransf_31; pfam13847 718251007654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251007655 S-adenosylmethionine binding site [chemical binding]; other site 718251007656 molybdenum transport protein ModD; Provisional; Region: PRK06096 718251007657 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 718251007658 dimerization interface [polypeptide binding]; other site 718251007659 active site 718251007660 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 718251007661 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 718251007662 ParB-like nuclease domain; Region: ParB; smart00470 718251007663 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 718251007664 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 718251007665 Active Sites [active] 718251007666 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 718251007667 potassium uptake protein; Region: kup; TIGR00794 718251007668 K+ potassium transporter; Region: K_trans; pfam02705 718251007669 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 718251007670 homodimer interface [polypeptide binding]; other site 718251007671 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 718251007672 active site pocket [active] 718251007673 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 718251007674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251007675 ATP binding site [chemical binding]; other site 718251007676 Mg2+ binding site [ion binding]; other site 718251007677 G-X-G motif; other site 718251007678 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 718251007679 anti sigma factor interaction site; other site 718251007680 regulatory phosphorylation site [posttranslational modification]; other site 718251007681 Response regulator receiver domain; Region: Response_reg; pfam00072 718251007682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251007683 active site 718251007684 phosphorylation site [posttranslational modification] 718251007685 intermolecular recognition site; other site 718251007686 dimerization interface [polypeptide binding]; other site 718251007687 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 718251007688 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 718251007689 CHAP domain; Region: CHAP; cl17642 718251007690 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 718251007691 HdeA/HdeB family; Region: HdeA; cl05752 718251007692 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 718251007693 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 718251007694 putative ion selectivity filter; other site 718251007695 putative pore gating glutamate residue; other site 718251007696 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 718251007697 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 718251007698 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 718251007699 homodimer interface [polypeptide binding]; other site 718251007700 NADP binding site [chemical binding]; other site 718251007701 substrate binding site [chemical binding]; other site 718251007702 ribosome-associated protein; Provisional; Region: PRK11507 718251007703 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 718251007704 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 718251007705 active site 718251007706 HIGH motif; other site 718251007707 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 718251007708 KMSKS motif; other site 718251007709 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 718251007710 tRNA binding surface [nucleotide binding]; other site 718251007711 anticodon binding site; other site 718251007712 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 718251007713 substrate binding site [chemical binding]; other site 718251007714 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 718251007715 putative active site [active] 718251007716 putative metal binding site [ion binding]; other site 718251007717 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 718251007718 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718251007719 metal binding site [ion binding]; metal-binding site 718251007720 active site 718251007721 I-site; other site 718251007722 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 718251007723 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 718251007724 ATP-grasp domain; Region: ATP-grasp; pfam02222 718251007725 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 718251007726 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 718251007727 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 718251007728 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 718251007729 Walker A/P-loop; other site 718251007730 ATP binding site [chemical binding]; other site 718251007731 Q-loop/lid; other site 718251007732 ABC transporter signature motif; other site 718251007733 Walker B; other site 718251007734 D-loop; other site 718251007735 H-loop/switch region; other site 718251007736 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 718251007737 active site 718251007738 catalytic triad [active] 718251007739 oxyanion hole [active] 718251007740 switch loop; other site 718251007741 oxidoreductase; Provisional; Region: PRK08017 718251007742 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 718251007743 NADP binding site [chemical binding]; other site 718251007744 active site 718251007745 steroid binding site; other site 718251007746 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 718251007747 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 718251007748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 718251007749 hypothetical protein; Provisional; Region: PRK10519 718251007750 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 718251007751 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 718251007752 metal binding site [ion binding]; metal-binding site 718251007753 dimer interface [polypeptide binding]; other site 718251007754 Protein of unknown function (DUF465); Region: DUF465; cl01070 718251007755 enolase; Provisional; Region: eno; PRK00077 718251007756 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 718251007757 dimer interface [polypeptide binding]; other site 718251007758 metal binding site [ion binding]; metal-binding site 718251007759 substrate binding pocket [chemical binding]; other site 718251007760 CTP synthetase; Validated; Region: pyrG; PRK05380 718251007761 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 718251007762 Catalytic site [active] 718251007763 active site 718251007764 UTP binding site [chemical binding]; other site 718251007765 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 718251007766 active site 718251007767 putative oxyanion hole; other site 718251007768 catalytic triad [active] 718251007769 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 718251007770 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 718251007771 homodimer interface [polypeptide binding]; other site 718251007772 metal binding site [ion binding]; metal-binding site 718251007773 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 718251007774 homodimer interface [polypeptide binding]; other site 718251007775 active site 718251007776 putative chemical substrate binding site [chemical binding]; other site 718251007777 metal binding site [ion binding]; metal-binding site 718251007778 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 718251007779 HD domain; Region: HD_4; pfam13328 718251007780 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 718251007781 synthetase active site [active] 718251007782 NTP binding site [chemical binding]; other site 718251007783 metal binding site [ion binding]; metal-binding site 718251007784 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 718251007785 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 718251007786 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 718251007787 TRAM domain; Region: TRAM; pfam01938 718251007788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251007789 S-adenosylmethionine binding site [chemical binding]; other site 718251007790 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 718251007791 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 718251007792 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718251007793 dimerization interface [polypeptide binding]; other site 718251007794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251007795 dimer interface [polypeptide binding]; other site 718251007796 phosphorylation site [posttranslational modification] 718251007797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251007798 ATP binding site [chemical binding]; other site 718251007799 Mg2+ binding site [ion binding]; other site 718251007800 G-X-G motif; other site 718251007801 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 718251007802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251007803 active site 718251007804 phosphorylation site [posttranslational modification] 718251007805 intermolecular recognition site; other site 718251007806 dimerization interface [polypeptide binding]; other site 718251007807 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 718251007808 putative binding surface; other site 718251007809 active site 718251007810 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 718251007811 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 718251007812 active site 718251007813 hydrophilic channel; other site 718251007814 dimerization interface [polypeptide binding]; other site 718251007815 catalytic residues [active] 718251007816 active site lid [active] 718251007817 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 718251007818 Recombination protein O N terminal; Region: RecO_N; pfam11967 718251007819 Recombination protein O C terminal; Region: RecO_C; pfam02565 718251007820 GTPase Era; Reviewed; Region: era; PRK00089 718251007821 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 718251007822 G1 box; other site 718251007823 GTP/Mg2+ binding site [chemical binding]; other site 718251007824 Switch I region; other site 718251007825 G2 box; other site 718251007826 Switch II region; other site 718251007827 G3 box; other site 718251007828 G4 box; other site 718251007829 G5 box; other site 718251007830 KH domain; Region: KH_2; pfam07650 718251007831 ribonuclease III; Reviewed; Region: rnc; PRK00102 718251007832 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 718251007833 dimerization interface [polypeptide binding]; other site 718251007834 active site 718251007835 metal binding site [ion binding]; metal-binding site 718251007836 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 718251007837 dsRNA binding site [nucleotide binding]; other site 718251007838 signal peptidase I; Provisional; Region: PRK10861 718251007839 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 718251007840 Catalytic site [active] 718251007841 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 718251007842 Catalytic site [active] 718251007843 GTP-binding protein LepA; Provisional; Region: PRK05433 718251007844 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 718251007845 G1 box; other site 718251007846 putative GEF interaction site [polypeptide binding]; other site 718251007847 GTP/Mg2+ binding site [chemical binding]; other site 718251007848 Switch I region; other site 718251007849 G2 box; other site 718251007850 G3 box; other site 718251007851 Switch II region; other site 718251007852 G4 box; other site 718251007853 G5 box; other site 718251007854 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 718251007855 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 718251007856 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 718251007857 SoxR reducing system protein RseC; Provisional; Region: PRK10862 718251007858 anti-sigma E factor; Provisional; Region: rseB; PRK09455 718251007859 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 718251007860 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 718251007861 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 718251007862 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 718251007863 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 718251007864 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 718251007865 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 718251007866 DNA binding residues [nucleotide binding] 718251007867 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 718251007868 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 718251007869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251007870 S-adenosylmethionine binding site [chemical binding]; other site 718251007871 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 718251007872 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 718251007873 ATP binding site [chemical binding]; other site 718251007874 Mg++ binding site [ion binding]; other site 718251007875 motif III; other site 718251007876 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 718251007877 nucleotide binding region [chemical binding]; other site 718251007878 ATP-binding site [chemical binding]; other site 718251007879 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 718251007880 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 718251007881 ligand binding site [chemical binding]; other site 718251007882 active site 718251007883 UGI interface [polypeptide binding]; other site 718251007884 catalytic site [active] 718251007885 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 718251007886 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 718251007887 dimer interface [polypeptide binding]; other site 718251007888 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 718251007889 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 718251007890 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 718251007891 recombination and repair protein; Provisional; Region: PRK10869 718251007892 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 718251007893 Walker A/P-loop; other site 718251007894 ATP binding site [chemical binding]; other site 718251007895 Q-loop/lid; other site 718251007896 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 718251007897 ABC transporter signature motif; other site 718251007898 Walker B; other site 718251007899 D-loop; other site 718251007900 H-loop/switch region; other site 718251007901 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 718251007902 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 718251007903 hypothetical protein; Validated; Region: PRK01777 718251007904 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 718251007905 putative coenzyme Q binding site [chemical binding]; other site 718251007906 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 718251007907 SmpB-tmRNA interface; other site 718251007908 integrase; Provisional; Region: PRK09692 718251007909 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 718251007910 active site 718251007911 Int/Topo IB signature motif; other site 718251007912 putative transposase OrfB; Reviewed; Region: PHA02517 718251007913 HTH-like domain; Region: HTH_21; pfam13276 718251007914 Integrase core domain; Region: rve; pfam00665 718251007915 Integrase core domain; Region: rve_3; cl15866 718251007916 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 718251007917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 718251007918 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251007919 AAA domain; Region: AAA_23; pfam13476 718251007920 Walker A/P-loop; other site 718251007921 ATP binding site [chemical binding]; other site 718251007922 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251007923 Walker B; other site 718251007924 D-loop; other site 718251007925 H-loop/switch region; other site 718251007926 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 718251007927 putative active site [active] 718251007928 putative metal-binding site [ion binding]; other site 718251007929 Predicted GTPase [General function prediction only]; Region: COG3596 718251007930 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251007931 YfjP GTPase; Region: YfjP; cd11383 718251007932 G1 box; other site 718251007933 Walker A/P-loop; other site 718251007934 GTP/Mg2+ binding site [chemical binding]; other site 718251007935 ATP binding site [chemical binding]; other site 718251007936 Switch I region; other site 718251007937 G2 box; other site 718251007938 Switch II region; other site 718251007939 G3 box; other site 718251007940 G4 box; other site 718251007941 G5 box; other site 718251007942 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 718251007943 Domain of unknown function (DUF932); Region: DUF932; pfam06067 718251007944 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 718251007945 MPN+ (JAMM) motif; other site 718251007946 Zinc-binding site [ion binding]; other site 718251007947 Protein of unknown function (DUF987); Region: DUF987; pfam06174 718251007948 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 718251007949 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 718251007950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 718251007951 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 718251007952 homotrimer interaction site [polypeptide binding]; other site 718251007953 putative active site [active] 718251007954 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 718251007955 AzlC protein; Region: AzlC; pfam03591 718251007956 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 718251007957 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 718251007958 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 718251007959 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 718251007960 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cd00374 718251007961 CAS motifs; other site 718251007962 active site 718251007963 GAF domain; Region: GAF; cl17456 718251007964 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 718251007965 PAS domain; Region: PAS_9; pfam13426 718251007966 putative active site [active] 718251007967 heme pocket [chemical binding]; other site 718251007968 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 718251007969 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718251007970 metal binding site [ion binding]; metal-binding site 718251007971 active site 718251007972 I-site; other site 718251007973 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 718251007974 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 718251007975 gating phenylalanine in ion channel; other site 718251007976 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 718251007977 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251007978 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 718251007979 putative dimerization interface [polypeptide binding]; other site 718251007980 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 718251007981 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 718251007982 dimerization interface [polypeptide binding]; other site 718251007983 DPS ferroxidase diiron center [ion binding]; other site 718251007984 ion pore; other site 718251007985 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 718251007986 transcriptional repressor MprA; Provisional; Region: PRK10870 718251007987 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 718251007988 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 718251007989 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718251007990 HlyD family secretion protein; Region: HlyD_3; pfam13437 718251007991 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 718251007992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251007993 putative substrate translocation pore; other site 718251007994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251007995 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 718251007996 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 718251007997 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 718251007998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251007999 ABC-ATPase subunit interface; other site 718251008000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251008001 ABC-ATPase subunit interface; other site 718251008002 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 718251008003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251008004 Walker A/P-loop; other site 718251008005 ATP binding site [chemical binding]; other site 718251008006 Q-loop/lid; other site 718251008007 ABC transporter signature motif; other site 718251008008 Walker B; other site 718251008009 D-loop; other site 718251008010 H-loop/switch region; other site 718251008011 serine endoprotease; Provisional; Region: PRK10942 718251008012 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 718251008013 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 718251008014 protein binding site [polypeptide binding]; other site 718251008015 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 718251008016 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 718251008017 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 718251008018 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 718251008019 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 718251008020 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 718251008021 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 718251008022 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 718251008023 cobalamin binding residues [chemical binding]; other site 718251008024 putative BtuC binding residues; other site 718251008025 dimer interface [polypeptide binding]; other site 718251008026 hypothetical protein; Provisional; Region: PRK10578 718251008027 UPF0126 domain; Region: UPF0126; pfam03458 718251008028 UPF0126 domain; Region: UPF0126; pfam03458 718251008029 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 718251008030 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 718251008031 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 718251008032 Cl- selectivity filter; other site 718251008033 Cl- binding residues [ion binding]; other site 718251008034 pore gating glutamate residue; other site 718251008035 dimer interface [polypeptide binding]; other site 718251008036 H+/Cl- coupling transport residue; other site 718251008037 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 718251008038 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 718251008039 inhibitor-cofactor binding pocket; inhibition site 718251008040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251008041 catalytic residue [active] 718251008042 purine nucleoside phosphorylase; Provisional; Region: PRK08202 718251008043 putative transporter; Provisional; Region: PRK03699 718251008044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251008045 putative substrate translocation pore; other site 718251008046 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 718251008047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251008048 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718251008049 dimerization interface [polypeptide binding]; other site 718251008050 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 718251008051 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 718251008052 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 718251008053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251008054 putative substrate translocation pore; other site 718251008055 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 718251008056 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718251008057 GMP synthase; Reviewed; Region: guaA; PRK00074 718251008058 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 718251008059 AMP/PPi binding site [chemical binding]; other site 718251008060 candidate oxyanion hole; other site 718251008061 catalytic triad [active] 718251008062 potential glutamine specificity residues [chemical binding]; other site 718251008063 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 718251008064 ATP Binding subdomain [chemical binding]; other site 718251008065 Ligand Binding sites [chemical binding]; other site 718251008066 Dimerization subdomain; other site 718251008067 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 718251008068 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 718251008069 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 718251008070 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 718251008071 active site 718251008072 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 718251008073 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 718251008074 generic binding surface II; other site 718251008075 generic binding surface I; other site 718251008076 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 718251008077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 718251008078 TPR motif; other site 718251008079 binding surface 718251008080 Cytochrome C biogenesis protein; Region: CcmH; cl01179 718251008081 heme lyase subunit NrfE; Provisional; Region: PRK10369 718251008082 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 718251008083 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 718251008084 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 718251008085 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 718251008086 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 718251008087 Trm112p-like protein; Region: Trm112p; cl01066 718251008088 Predicted permeases [General function prediction only]; Region: COG0679 718251008089 GTP-binding protein Der; Reviewed; Region: PRK00093 718251008090 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 718251008091 G1 box; other site 718251008092 GTP/Mg2+ binding site [chemical binding]; other site 718251008093 Switch I region; other site 718251008094 G2 box; other site 718251008095 Switch II region; other site 718251008096 G3 box; other site 718251008097 G4 box; other site 718251008098 G5 box; other site 718251008099 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 718251008100 G1 box; other site 718251008101 GTP/Mg2+ binding site [chemical binding]; other site 718251008102 Switch I region; other site 718251008103 G2 box; other site 718251008104 G3 box; other site 718251008105 Switch II region; other site 718251008106 G4 box; other site 718251008107 G5 box; other site 718251008108 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 718251008109 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 718251008110 Trp docking motif [polypeptide binding]; other site 718251008111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 718251008112 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 718251008113 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 718251008114 dimer interface [polypeptide binding]; other site 718251008115 motif 1; other site 718251008116 active site 718251008117 motif 2; other site 718251008118 motif 3; other site 718251008119 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 718251008120 anticodon binding site; other site 718251008121 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 718251008122 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 718251008123 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 718251008124 cytoskeletal protein RodZ; Provisional; Region: PRK10856 718251008125 Helix-turn-helix domain; Region: HTH_25; pfam13413 718251008126 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 718251008127 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 718251008128 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718251008129 binding surface 718251008130 TPR motif; other site 718251008131 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 718251008132 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718251008133 FeS/SAM binding site; other site 718251008134 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 718251008135 active site 718251008136 multimer interface [polypeptide binding]; other site 718251008137 SseB protein; Region: SseB; cl06279 718251008138 aminopeptidase B; Provisional; Region: PRK05015 718251008139 Peptidase; Region: DUF3663; pfam12404 718251008140 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 718251008141 interface (dimer of trimers) [polypeptide binding]; other site 718251008142 Substrate-binding/catalytic site; other site 718251008143 Zn-binding sites [ion binding]; other site 718251008144 Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123 718251008145 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 718251008146 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 718251008147 catalytic loop [active] 718251008148 iron binding site [ion binding]; other site 718251008149 chaperone protein HscA; Provisional; Region: hscA; PRK05183 718251008150 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 718251008151 nucleotide binding site [chemical binding]; other site 718251008152 putative NEF/HSP70 interaction site [polypeptide binding]; other site 718251008153 SBD interface [polypeptide binding]; other site 718251008154 co-chaperone HscB; Provisional; Region: hscB; PRK05014 718251008155 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 718251008156 HSP70 interaction site [polypeptide binding]; other site 718251008157 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 718251008158 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 718251008159 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 718251008160 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 718251008161 trimerization site [polypeptide binding]; other site 718251008162 active site 718251008163 cysteine desulfurase; Provisional; Region: PRK14012 718251008164 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 718251008165 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718251008166 catalytic residue [active] 718251008167 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 718251008168 Rrf2 family protein; Region: rrf2_super; TIGR00738 718251008169 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 718251008170 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 718251008171 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 718251008172 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 718251008173 active site 718251008174 dimerization interface [polypeptide binding]; other site 718251008175 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 718251008176 PRD domain; Region: PRD; pfam00874 718251008177 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 718251008178 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 718251008179 dimer interface [polypeptide binding]; other site 718251008180 active site 718251008181 glycine-pyridoxal phosphate binding site [chemical binding]; other site 718251008182 folate binding site [chemical binding]; other site 718251008183 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 718251008184 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 718251008185 heme-binding site [chemical binding]; other site 718251008186 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 718251008187 FAD binding pocket [chemical binding]; other site 718251008188 FAD binding motif [chemical binding]; other site 718251008189 phosphate binding motif [ion binding]; other site 718251008190 beta-alpha-beta structure motif; other site 718251008191 NAD binding pocket [chemical binding]; other site 718251008192 Heme binding pocket [chemical binding]; other site 718251008193 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 718251008194 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 718251008195 active site 718251008196 catalytic site [active] 718251008197 substrate binding site [chemical binding]; other site 718251008198 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 718251008199 RNA/DNA hybrid binding site [nucleotide binding]; other site 718251008200 active site 718251008201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 718251008202 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 718251008203 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 718251008204 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 718251008205 N-acetyl-D-glucosamine binding site [chemical binding]; other site 718251008206 catalytic residue [active] 718251008207 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 718251008208 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 718251008209 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 718251008210 hypothetical protein; Provisional; Region: PRK05421 718251008211 putative catalytic site [active] 718251008212 putative phosphate binding site [ion binding]; other site 718251008213 putative metal binding site [ion binding]; other site 718251008214 protein disaggregation chaperone; Provisional; Region: PRK10865 718251008215 Clp amino terminal domain; Region: Clp_N; pfam02861 718251008216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251008217 Walker A motif; other site 718251008218 ATP binding site [chemical binding]; other site 718251008219 Walker B motif; other site 718251008220 arginine finger; other site 718251008221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251008222 Walker A motif; other site 718251008223 ATP binding site [chemical binding]; other site 718251008224 Walker B motif; other site 718251008225 arginine finger; other site 718251008226 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 718251008227 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 718251008228 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 718251008229 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 718251008230 active site 718251008231 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 718251008232 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 718251008233 30S subunit binding site; other site 718251008234 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 718251008235 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 718251008236 Prephenate dehydratase; Region: PDT; pfam00800 718251008237 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 718251008238 putative L-Phe binding site [chemical binding]; other site 718251008239 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 718251008240 Chorismate mutase type II; Region: CM_2; cl00693 718251008241 prephenate dehydrogenase; Validated; Region: PRK08507 718251008242 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 718251008243 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 718251008244 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 718251008245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251008246 active site 718251008247 phosphorylation site [posttranslational modification] 718251008248 intermolecular recognition site; other site 718251008249 dimerization interface [polypeptide binding]; other site 718251008250 LytTr DNA-binding domain; Region: LytTR; pfam04397 718251008251 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 718251008252 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 718251008253 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 718251008254 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 718251008255 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 718251008256 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 718251008257 Protein of unknown function, DUF481; Region: DUF481; cl01213 718251008258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251008259 S-adenosylmethionine binding site [chemical binding]; other site 718251008260 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 718251008261 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 718251008262 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 718251008263 RimM N-terminal domain; Region: RimM; pfam01782 718251008264 PRC-barrel domain; Region: PRC; pfam05239 718251008265 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 718251008266 signal recognition particle protein; Provisional; Region: PRK10867 718251008267 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 718251008268 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 718251008269 P loop; other site 718251008270 GTP binding site [chemical binding]; other site 718251008271 Signal peptide binding domain; Region: SRP_SPB; pfam02978 718251008272 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 718251008273 Domain of unknown function DUF21; Region: DUF21; pfam01595 718251008274 hypothetical protein; Provisional; Region: PRK11573 718251008275 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 718251008276 Transporter associated domain; Region: CorC_HlyC; smart01091 718251008277 S-ribosylhomocysteinase; Provisional; Region: PRK02260 718251008278 glutamate--cysteine ligase; Provisional; Region: PRK02107 718251008279 Predicted membrane protein [Function unknown]; Region: COG1238 718251008280 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 718251008281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251008282 motif II; other site 718251008283 carbon storage regulator; Provisional; Region: PRK01712 718251008284 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 718251008285 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 718251008286 motif 1; other site 718251008287 active site 718251008288 motif 2; other site 718251008289 motif 3; other site 718251008290 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 718251008291 DHHA1 domain; Region: DHHA1; pfam02272 718251008292 recombination regulator RecX; Reviewed; Region: recX; PRK00117 718251008293 recombinase A; Provisional; Region: recA; PRK09354 718251008294 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 718251008295 hexamer interface [polypeptide binding]; other site 718251008296 Walker A motif; other site 718251008297 ATP binding site [chemical binding]; other site 718251008298 Walker B motif; other site 718251008299 Competence-damaged protein; Region: CinA; cl00666 718251008300 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 718251008301 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 718251008302 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 718251008303 Autotransporter beta-domain; Region: Autotransporter; smart00869 718251008304 MarC family integral membrane protein; Region: MarC; cl00919 718251008305 amino acid transporter; Region: 2A0306; TIGR00909 718251008306 glutaminase; Reviewed; Region: PRK12356 718251008307 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 718251008308 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 718251008309 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 718251008310 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251008311 catalytic residue [active] 718251008312 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 718251008313 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718251008314 dimer interface [polypeptide binding]; other site 718251008315 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 718251008316 putative CheW interface [polypeptide binding]; other site 718251008317 acid-resistance protein; Provisional; Region: hdeB; PRK11566 718251008318 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 718251008319 DNA binding residues [nucleotide binding] 718251008320 dimerization interface [polypeptide binding]; other site 718251008321 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 718251008322 MutS domain I; Region: MutS_I; pfam01624 718251008323 MutS domain II; Region: MutS_II; pfam05188 718251008324 MutS domain III; Region: MutS_III; pfam05192 718251008325 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 718251008326 Walker A/P-loop; other site 718251008327 ATP binding site [chemical binding]; other site 718251008328 Q-loop/lid; other site 718251008329 ABC transporter signature motif; other site 718251008330 Walker B; other site 718251008331 D-loop; other site 718251008332 H-loop/switch region; other site 718251008333 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 718251008334 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 718251008335 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 718251008336 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 718251008337 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 718251008338 DNA binding residues [nucleotide binding] 718251008339 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 718251008340 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 718251008341 Peptidase family M23; Region: Peptidase_M23; pfam01551 718251008342 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 718251008343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251008344 S-adenosylmethionine binding site [chemical binding]; other site 718251008345 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 718251008346 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 718251008347 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 718251008348 Permutation of conserved domain; other site 718251008349 active site 718251008350 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 718251008351 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 718251008352 homotrimer interaction site [polypeptide binding]; other site 718251008353 zinc binding site [ion binding]; other site 718251008354 CDP-binding sites; other site 718251008355 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 718251008356 substrate binding site; other site 718251008357 dimer interface; other site 718251008358 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 718251008359 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 718251008360 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 718251008361 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 718251008362 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 718251008363 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 718251008364 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 718251008365 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 718251008366 putative active site [active] 718251008367 Ap4A binding site [chemical binding]; other site 718251008368 nudix motif; other site 718251008369 putative metal binding site [ion binding]; other site 718251008370 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 718251008371 putative DNA-binding cleft [nucleotide binding]; other site 718251008372 putative DNA clevage site; other site 718251008373 molecular lever; other site 718251008374 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 718251008375 alkaline phosphatase; Provisional; Region: PRK10518 718251008376 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 718251008377 dimer interface [polypeptide binding]; other site 718251008378 active site 718251008379 lysophospholipid transporter LplT; Provisional; Region: PRK11195 718251008380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251008381 putative substrate translocation pore; other site 718251008382 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 718251008383 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 718251008384 putative acyl-acceptor binding pocket; other site 718251008385 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 718251008386 acyl-activating enzyme (AAE) consensus motif; other site 718251008387 putative AMP binding site [chemical binding]; other site 718251008388 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 718251008389 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718251008390 DNA binding site [nucleotide binding] 718251008391 domain linker motif; other site 718251008392 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 718251008393 dimerization interface (closed form) [polypeptide binding]; other site 718251008394 ligand binding site [chemical binding]; other site 718251008395 Transcriptional regulators [Transcription]; Region: PurR; COG1609 718251008396 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718251008397 DNA binding site [nucleotide binding] 718251008398 domain linker motif; other site 718251008399 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 718251008400 dimerization interface (closed form) [polypeptide binding]; other site 718251008401 ligand binding site [chemical binding]; other site 718251008402 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 718251008403 4Fe-4S binding domain; Region: Fer4; cl02805 718251008404 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 718251008405 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 718251008406 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 718251008407 NADH dehydrogenase; Region: NADHdh; cl00469 718251008408 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 718251008409 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 718251008410 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 718251008411 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 718251008412 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 718251008413 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 718251008414 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 718251008415 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 718251008416 nickel binding site [ion binding]; other site 718251008417 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718251008418 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718251008419 molybdopterin cofactor binding site; other site 718251008420 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 718251008421 molybdopterin cofactor binding site; other site 718251008422 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 718251008423 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 718251008424 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 718251008425 Acylphosphatase; Region: Acylphosphatase; pfam00708 718251008426 HypF finger; Region: zf-HYPF; pfam07503 718251008427 HypF finger; Region: zf-HYPF; pfam07503 718251008428 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 718251008429 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 718251008430 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 718251008431 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718251008432 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 718251008433 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 718251008434 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 718251008435 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 718251008436 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 718251008437 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 718251008438 dimerization interface [polypeptide binding]; other site 718251008439 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 718251008440 ATP binding site [chemical binding]; other site 718251008441 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 718251008442 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 718251008443 GAF domain; Region: GAF; pfam01590 718251008444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251008445 Walker A motif; other site 718251008446 ATP binding site [chemical binding]; other site 718251008447 Walker B motif; other site 718251008448 arginine finger; other site 718251008449 diaminopimelate decarboxylase; Provisional; Region: PRK11165 718251008450 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 718251008451 active site 718251008452 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 718251008453 substrate binding site [chemical binding]; other site 718251008454 catalytic residues [active] 718251008455 dimer interface [polypeptide binding]; other site 718251008456 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 718251008457 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251008458 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718251008459 dimerization interface [polypeptide binding]; other site 718251008460 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 718251008461 Sulfatase; Region: Sulfatase; cl17466 718251008462 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 718251008463 Autotransporter beta-domain; Region: Autotransporter; pfam03797 718251008464 Lyase, N terminal; Region: Lyase_N; pfam09092 718251008465 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 718251008466 substrate binding site [chemical binding]; other site 718251008467 catalytic residues [active] 718251008468 Lyase, N terminal; Region: Lyase_N; pfam09092 718251008469 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706 718251008470 substrate binding site [chemical binding]; other site 718251008471 catalytic residues [active] 718251008472 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 718251008473 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 718251008474 putative acyl-acceptor binding pocket; other site 718251008475 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 718251008476 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 718251008477 trimer interface [polypeptide binding]; other site 718251008478 Haemagglutinin; Region: HIM; pfam05662 718251008479 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 718251008480 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 718251008481 dimer interface [polypeptide binding]; other site 718251008482 putative anticodon binding site; other site 718251008483 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 718251008484 motif 1; other site 718251008485 active site 718251008486 motif 2; other site 718251008487 motif 3; other site 718251008488 peptide chain release factor 2; Provisional; Region: PRK08787 718251008489 This domain is found in peptide chain release factors; Region: PCRF; smart00937 718251008490 RF-1 domain; Region: RF-1; pfam00472 718251008491 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 718251008492 DHH family; Region: DHH; pfam01368 718251008493 DHHA1 domain; Region: DHHA1; pfam02272 718251008494 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 718251008495 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 718251008496 dimerization domain [polypeptide binding]; other site 718251008497 dimer interface [polypeptide binding]; other site 718251008498 catalytic residues [active] 718251008499 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 718251008500 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 718251008501 active site 718251008502 Int/Topo IB signature motif; other site 718251008503 flavodoxin FldB; Provisional; Region: PRK12359 718251008504 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 718251008505 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 718251008506 putative global regulator; Reviewed; Region: PRK09559 718251008507 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 718251008508 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 718251008509 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 718251008510 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 718251008511 shikimate binding site; other site 718251008512 NAD(P) binding site [chemical binding]; other site 718251008513 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 718251008514 hemolysin; Provisional; Region: PRK15087 718251008515 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 718251008516 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 718251008517 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 718251008518 glycine dehydrogenase; Provisional; Region: PRK05367 718251008519 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 718251008520 tetramer interface [polypeptide binding]; other site 718251008521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251008522 catalytic residue [active] 718251008523 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 718251008524 tetramer interface [polypeptide binding]; other site 718251008525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251008526 catalytic residue [active] 718251008527 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 718251008528 lipoyl attachment site [posttranslational modification]; other site 718251008529 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 718251008530 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 718251008531 oxidoreductase; Provisional; Region: PRK08013 718251008532 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 718251008533 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 718251008534 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 718251008535 proline aminopeptidase P II; Provisional; Region: PRK10879 718251008536 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 718251008537 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 718251008538 active site 718251008539 hypothetical protein; Reviewed; Region: PRK01736 718251008540 Z-ring-associated protein; Provisional; Region: PRK10972 718251008541 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 718251008542 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 718251008543 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 718251008544 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 718251008545 ligand binding site [chemical binding]; other site 718251008546 NAD binding site [chemical binding]; other site 718251008547 tetramer interface [polypeptide binding]; other site 718251008548 catalytic site [active] 718251008549 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 718251008550 L-serine binding site [chemical binding]; other site 718251008551 ACT domain interface; other site 718251008552 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 718251008553 tetramer (dimer of dimers) interface [polypeptide binding]; other site 718251008554 active site 718251008555 dimer interface [polypeptide binding]; other site 718251008556 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 718251008557 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251008558 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 718251008559 putative dimerization interface [polypeptide binding]; other site 718251008560 oxidative stress defense protein; Provisional; Region: PRK11087 718251008561 Uncharacterized conserved protein [Function unknown]; Region: COG2968 718251008562 LysE type translocator; Region: LysE; cl00565 718251008563 mechanosensitive channel MscS; Provisional; Region: PRK10334 718251008564 Mechanosensitive ion channel; Region: MS_channel; pfam00924 718251008565 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 718251008566 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 718251008567 active site 718251008568 intersubunit interface [polypeptide binding]; other site 718251008569 zinc binding site [ion binding]; other site 718251008570 Na+ binding site [ion binding]; other site 718251008571 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 718251008572 Phosphoglycerate kinase; Region: PGK; pfam00162 718251008573 substrate binding site [chemical binding]; other site 718251008574 hinge regions; other site 718251008575 ADP binding site [chemical binding]; other site 718251008576 catalytic site [active] 718251008577 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 718251008578 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 718251008579 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 718251008580 transketolase; Reviewed; Region: PRK12753 718251008581 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 718251008582 TPP-binding site [chemical binding]; other site 718251008583 dimer interface [polypeptide binding]; other site 718251008584 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 718251008585 PYR/PP interface [polypeptide binding]; other site 718251008586 dimer interface [polypeptide binding]; other site 718251008587 TPP binding site [chemical binding]; other site 718251008588 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 718251008589 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 718251008590 Sulfatase; Region: Sulfatase; cl17466 718251008591 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 718251008592 agmatinase; Region: agmatinase; TIGR01230 718251008593 oligomer interface [polypeptide binding]; other site 718251008594 putative active site [active] 718251008595 Mn binding site [ion binding]; other site 718251008596 arginine decarboxylase; Provisional; Region: PRK05354 718251008597 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 718251008598 dimer interface [polypeptide binding]; other site 718251008599 active site 718251008600 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 718251008601 catalytic residues [active] 718251008602 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 718251008603 S-adenosylmethionine synthetase; Validated; Region: PRK05250 718251008604 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 718251008605 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 718251008606 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 718251008607 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 718251008608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251008609 putative substrate translocation pore; other site 718251008610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251008611 peptidase PmbA; Provisional; Region: PRK11040 718251008612 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 718251008613 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 718251008614 hypothetical protein; Provisional; Region: PRK05255 718251008615 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 718251008616 RNAase interaction site [polypeptide binding]; other site 718251008617 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 718251008618 active site 718251008619 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 718251008620 beta-galactosidase; Region: BGL; TIGR03356 718251008621 DctM-like transporters; Region: DctM; pfam06808 718251008622 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 718251008623 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 718251008624 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 718251008625 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 718251008626 cell density-dependent motility repressor; Provisional; Region: PRK10082 718251008627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251008628 LysR substrate binding domain; Region: LysR_substrate; pfam03466 718251008629 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 718251008630 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 718251008631 active site 718251008632 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 718251008633 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 718251008634 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 718251008635 ligand binding site [chemical binding]; other site 718251008636 flexible hinge region; other site 718251008637 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 718251008638 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 718251008639 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 718251008640 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 718251008641 nucleoside transporter; Region: 2A0110; TIGR00889 718251008642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251008643 putative substrate translocation pore; other site 718251008644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 718251008645 short chain dehydrogenase; Provisional; Region: PRK07041 718251008646 NAD(P) binding site [chemical binding]; other site 718251008647 active site 718251008648 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718251008649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251008650 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 718251008651 putative effector binding pocket; other site 718251008652 dimerization interface [polypeptide binding]; other site 718251008653 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 718251008654 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 718251008655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 718251008656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251008657 S-adenosylmethionine binding site [chemical binding]; other site 718251008658 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718251008659 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251008660 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718251008661 dimerization interface [polypeptide binding]; other site 718251008662 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 718251008663 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 718251008664 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 718251008665 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 718251008666 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 718251008667 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 718251008668 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 718251008669 Rubredoxin; Region: Rubredoxin; pfam00301 718251008670 iron binding site [ion binding]; other site 718251008671 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 718251008672 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 718251008673 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 718251008674 putative substrate-binding site; other site 718251008675 nickel binding site [ion binding]; other site 718251008676 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 718251008677 hydrogenase 1 large subunit; Provisional; Region: PRK10170 718251008678 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 718251008679 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 718251008680 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 718251008681 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 718251008682 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 718251008683 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 718251008684 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718251008685 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 718251008686 catalytic residue [active] 718251008687 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 718251008688 putrescine transporter; Provisional; Region: potE; PRK10655 718251008689 lysine decarboxylase CadA; Provisional; Region: PRK15400 718251008690 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 718251008691 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 718251008692 homodimer interface [polypeptide binding]; other site 718251008693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251008694 catalytic residue [active] 718251008695 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 718251008696 hypothetical protein; Provisional; Region: PRK09273 718251008697 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 718251008698 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 718251008699 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 718251008700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251008701 putative substrate translocation pore; other site 718251008702 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 718251008703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251008704 active site 718251008705 phosphorylation site [posttranslational modification] 718251008706 intermolecular recognition site; other site 718251008707 dimerization interface [polypeptide binding]; other site 718251008708 LytTr DNA-binding domain; Region: LytTR; smart00850 718251008709 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 718251008710 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 718251008711 Histidine kinase; Region: His_kinase; pfam06580 718251008712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251008713 ATP binding site [chemical binding]; other site 718251008714 Mg2+ binding site [ion binding]; other site 718251008715 G-X-G motif; other site 718251008716 alpha-galactosidase; Provisional; Region: PRK15076 718251008717 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 718251008718 NAD binding site [chemical binding]; other site 718251008719 sugar binding site [chemical binding]; other site 718251008720 divalent metal binding site [ion binding]; other site 718251008721 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 718251008722 dimer interface [polypeptide binding]; other site 718251008723 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 718251008724 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718251008725 TM-ABC transporter signature motif; other site 718251008726 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 718251008727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251008728 Walker A/P-loop; other site 718251008729 ATP binding site [chemical binding]; other site 718251008730 Q-loop/lid; other site 718251008731 ABC transporter signature motif; other site 718251008732 Walker B; other site 718251008733 D-loop; other site 718251008734 H-loop/switch region; other site 718251008735 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 718251008736 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 718251008737 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 718251008738 Protein of unknown function (DUF1045); Region: DUF1045; cl15435 718251008739 Transcriptional regulators [Transcription]; Region: PurR; COG1609 718251008740 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 718251008741 putative outer membrane porin protein; Provisional; Region: PRK11379 718251008742 glucuronide transporter; Provisional; Region: PRK09848 718251008743 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 718251008744 beta-D-glucuronidase; Provisional; Region: PRK10150 718251008745 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 718251008746 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 718251008747 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 718251008748 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 718251008749 TrkA-N domain; Region: TrkA_N; pfam02254 718251008750 Transcriptional regulators [Transcription]; Region: PurR; COG1609 718251008751 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718251008752 DNA binding site [nucleotide binding] 718251008753 domain linker motif; other site 718251008754 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 718251008755 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 718251008756 active site 718251008757 phosphorylation site [posttranslational modification] 718251008758 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 718251008759 active site 718251008760 P-loop; other site 718251008761 phosphorylation site [posttranslational modification] 718251008762 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 718251008763 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 718251008764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251008765 motif II; other site 718251008766 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 718251008767 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 718251008768 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 718251008769 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 718251008770 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 718251008771 active site 718251008772 DNA binding site [nucleotide binding] 718251008773 Int/Topo IB signature motif; other site 718251008774 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 718251008775 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 718251008776 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 718251008777 Autotransporter beta-domain; Region: Autotransporter; cl17461 718251008778 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 718251008779 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 718251008780 amidase catalytic site [active] 718251008781 Zn binding residues [ion binding]; other site 718251008782 substrate binding site [chemical binding]; other site 718251008783 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 718251008784 chorismate mutase; Provisional; Region: PRK08055 718251008785 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 718251008786 Protein of unknown function DUF45; Region: DUF45; pfam01863 718251008787 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 718251008788 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 718251008789 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718251008790 ATP binding site [chemical binding]; other site 718251008791 putative Mg++ binding site [ion binding]; other site 718251008792 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 718251008793 ADP-ribose binding site [chemical binding]; other site 718251008794 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 718251008795 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 718251008796 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 718251008797 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 718251008798 HsdM N-terminal domain; Region: HsdM_N; pfam12161 718251008799 Methyltransferase domain; Region: Methyltransf_26; pfam13659 718251008800 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 718251008801 DNA methylase; Region: N6_N4_Mtase; cl17433 718251008802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251008803 S-adenosylmethionine binding site [chemical binding]; other site 718251008804 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 718251008805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 718251008806 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 718251008807 active site 718251008808 catalytic residues [active] 718251008809 DNA binding site [nucleotide binding] 718251008810 Int/Topo IB signature motif; other site 718251008811 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 718251008812 active site 718251008813 catalytic residues [active] 718251008814 DNA binding site [nucleotide binding] 718251008815 Int/Topo IB signature motif; other site 718251008816 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 718251008817 integrase; Provisional; Region: PRK09692 718251008818 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 718251008819 active site 718251008820 Int/Topo IB signature motif; other site 718251008821 L,D-transpeptidase; Provisional; Region: PRK10260 718251008822 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 718251008823 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 718251008824 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 718251008825 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 718251008826 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 718251008827 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 718251008828 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 718251008829 multifunctional aminopeptidase A; Provisional; Region: PRK00913 718251008830 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 718251008831 interface (dimer of trimers) [polypeptide binding]; other site 718251008832 Substrate-binding/catalytic site; other site 718251008833 Zn-binding sites [ion binding]; other site 718251008834 DNA polymerase III subunit chi; Validated; Region: PRK05728 718251008835 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 718251008836 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 718251008837 HIGH motif; other site 718251008838 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 718251008839 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 718251008840 active site 718251008841 KMSKS motif; other site 718251008842 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 718251008843 tRNA binding surface [nucleotide binding]; other site 718251008844 anticodon binding site; other site 718251008845 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 718251008846 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 718251008847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251008848 dimer interface [polypeptide binding]; other site 718251008849 conserved gate region; other site 718251008850 putative PBP binding loops; other site 718251008851 ABC-ATPase subunit interface; other site 718251008852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 718251008853 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 718251008854 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 718251008855 Walker A/P-loop; other site 718251008856 ATP binding site [chemical binding]; other site 718251008857 Q-loop/lid; other site 718251008858 ABC transporter signature motif; other site 718251008859 Walker B; other site 718251008860 D-loop; other site 718251008861 H-loop/switch region; other site 718251008862 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 718251008863 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 718251008864 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 718251008865 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 718251008866 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 718251008867 dimer interface [polypeptide binding]; other site 718251008868 active site 718251008869 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 718251008870 substrate binding site [chemical binding]; other site 718251008871 catalytic residue [active] 718251008872 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 718251008873 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 718251008874 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 718251008875 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 718251008876 catalytic residue [active] 718251008877 PAS fold; Region: PAS_4; pfam08448 718251008878 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 718251008879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251008880 Walker A motif; other site 718251008881 ATP binding site [chemical binding]; other site 718251008882 Walker B motif; other site 718251008883 arginine finger; other site 718251008884 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 718251008885 RNase E inhibitor protein; Provisional; Region: PRK11191 718251008886 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 718251008887 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 718251008888 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 718251008889 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 718251008890 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 718251008891 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 718251008892 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 718251008893 Cysteine-rich domain; Region: CCG; pfam02754 718251008894 Cysteine-rich domain; Region: CCG; pfam02754 718251008895 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 718251008896 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 718251008897 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 718251008898 hydroxyglutarate oxidase; Provisional; Region: PRK11728 718251008899 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 718251008900 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 718251008901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251008902 putative substrate translocation pore; other site 718251008903 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 718251008904 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 718251008905 active site 718251008906 catalytic site [active] 718251008907 metal binding site [ion binding]; metal-binding site 718251008908 putative glutathione S-transferase; Provisional; Region: PRK10357 718251008909 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 718251008910 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 718251008911 dimer interface [polypeptide binding]; other site 718251008912 N-terminal domain interface [polypeptide binding]; other site 718251008913 putative substrate binding pocket (H-site) [chemical binding]; other site 718251008914 selenocysteine synthase; Provisional; Region: PRK04311 718251008915 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 718251008916 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 718251008917 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 718251008918 catalytic residue [active] 718251008919 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 718251008920 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 718251008921 G1 box; other site 718251008922 putative GEF interaction site [polypeptide binding]; other site 718251008923 GTP/Mg2+ binding site [chemical binding]; other site 718251008924 Switch I region; other site 718251008925 G2 box; other site 718251008926 G3 box; other site 718251008927 Switch II region; other site 718251008928 G4 box; other site 718251008929 G5 box; other site 718251008930 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 718251008931 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 718251008932 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 718251008933 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 718251008934 voltage-gated potassium channel; Provisional; Region: PRK10537 718251008935 Ion channel; Region: Ion_trans_2; pfam07885 718251008936 TrkA-N domain; Region: TrkA_N; pfam02254 718251008937 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 718251008938 homotrimer interaction site [polypeptide binding]; other site 718251008939 putative active site [active] 718251008940 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 718251008941 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 718251008942 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 718251008943 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 718251008944 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 718251008945 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 718251008946 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 718251008947 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 718251008948 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 718251008949 HlyD family secretion protein; Region: HlyD_3; pfam13437 718251008950 efflux system membrane protein; Provisional; Region: PRK11594 718251008951 transcriptional regulator; Provisional; Region: PRK10632 718251008952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251008953 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 718251008954 putative effector binding pocket; other site 718251008955 dimerization interface [polypeptide binding]; other site 718251008956 protease TldD; Provisional; Region: tldD; PRK10735 718251008957 nitrilase; Region: PLN02798 718251008958 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 718251008959 putative active site [active] 718251008960 catalytic triad [active] 718251008961 dimer interface [polypeptide binding]; other site 718251008962 hypothetical protein; Provisional; Region: PRK10899 718251008963 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 718251008964 ribonuclease G; Provisional; Region: PRK11712 718251008965 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 718251008966 homodimer interface [polypeptide binding]; other site 718251008967 oligonucleotide binding site [chemical binding]; other site 718251008968 Maf-like protein; Region: Maf; pfam02545 718251008969 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 718251008970 active site 718251008971 dimer interface [polypeptide binding]; other site 718251008972 rod shape-determining protein MreD; Provisional; Region: PRK11060 718251008973 rod shape-determining protein MreC; Region: MreC; pfam04085 718251008974 rod shape-determining protein MreB; Provisional; Region: PRK13927 718251008975 MreB and similar proteins; Region: MreB_like; cd10225 718251008976 nucleotide binding site [chemical binding]; other site 718251008977 Mg binding site [ion binding]; other site 718251008978 putative protofilament interaction site [polypeptide binding]; other site 718251008979 RodZ interaction site [polypeptide binding]; other site 718251008980 regulatory protein CsrD; Provisional; Region: PRK11059 718251008981 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718251008982 metal binding site [ion binding]; metal-binding site 718251008983 I-site; other site 718251008984 active site 718251008985 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718251008986 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 718251008987 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 718251008988 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 718251008989 NADP binding site [chemical binding]; other site 718251008990 dimer interface [polypeptide binding]; other site 718251008991 TMAO/DMSO reductase; Reviewed; Region: PRK05363 718251008992 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 718251008993 Moco binding site; other site 718251008994 metal coordination site [ion binding]; other site 718251008995 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 718251008996 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 718251008997 Dehydroquinase class II; Region: DHquinase_II; pfam01220 718251008998 active site 718251008999 trimer interface [polypeptide binding]; other site 718251009000 dimer interface [polypeptide binding]; other site 718251009001 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 718251009002 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 718251009003 carboxyltransferase (CT) interaction site; other site 718251009004 biotinylation site [posttranslational modification]; other site 718251009005 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 718251009006 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 718251009007 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 718251009008 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 718251009009 hypothetical protein; Provisional; Region: PRK10633 718251009010 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 718251009011 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 718251009012 Na binding site [ion binding]; other site 718251009013 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 718251009014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 718251009015 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 718251009016 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 718251009017 FMN binding site [chemical binding]; other site 718251009018 active site 718251009019 catalytic residues [active] 718251009020 substrate binding site [chemical binding]; other site 718251009021 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 718251009022 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 718251009023 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1888 718251009024 hypothetical protein; Provisional; Region: PRK10556 718251009025 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 718251009026 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 718251009027 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718251009028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251009029 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 718251009030 putative dimerization interface [polypeptide binding]; other site 718251009031 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 718251009032 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 718251009033 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 718251009034 guanine deaminase; Provisional; Region: PRK09228 718251009035 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 718251009036 active site 718251009037 xanthine permease; Region: pbuX; TIGR03173 718251009038 putative hypoxanthine oxidase; Provisional; Region: PRK09800 718251009039 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 718251009040 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 718251009041 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 718251009042 putative oxidoreductase; Provisional; Region: PRK09799 718251009043 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 718251009044 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 718251009045 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 718251009046 active site 718251009047 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 718251009048 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 718251009049 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 718251009050 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718251009051 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 718251009052 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 718251009053 Ligand binding site; other site 718251009054 metal-binding site 718251009055 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 718251009056 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 718251009057 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 718251009058 XdhC Rossmann domain; Region: XdhC_C; pfam13478 718251009059 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 718251009060 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 718251009061 carbamate kinase; Reviewed; Region: PRK12686 718251009062 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 718251009063 putative substrate binding site [chemical binding]; other site 718251009064 homodimer interface [polypeptide binding]; other site 718251009065 nucleotide binding site [chemical binding]; other site 718251009066 nucleotide binding site [chemical binding]; other site 718251009067 phenylhydantoinase; Validated; Region: PRK08323 718251009068 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 718251009069 tetramer interface [polypeptide binding]; other site 718251009070 active site 718251009071 peptidase; Reviewed; Region: PRK13004 718251009072 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 718251009073 putative metal binding site [ion binding]; other site 718251009074 putative dimer interface [polypeptide binding]; other site 718251009075 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 718251009076 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 718251009077 catalytic residue [active] 718251009078 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 718251009079 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 718251009080 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 718251009081 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 718251009082 GAF domain; Region: GAF; cl17456 718251009083 PAS domain; Region: PAS; smart00091 718251009084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251009085 Walker A motif; other site 718251009086 ATP binding site [chemical binding]; other site 718251009087 Walker B motif; other site 718251009088 arginine finger; other site 718251009089 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 718251009090 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 718251009091 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 718251009092 dimer interface [polypeptide binding]; other site 718251009093 ssDNA binding site [nucleotide binding]; other site 718251009094 tetramer (dimer of dimers) interface [polypeptide binding]; other site 718251009095 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 718251009096 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 718251009097 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 718251009098 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 718251009099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 718251009100 Uncharacterized conserved protein [Function unknown]; Region: COG0432 718251009101 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 718251009102 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 718251009103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251009104 homodimer interface [polypeptide binding]; other site 718251009105 catalytic residue [active] 718251009106 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 718251009107 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 718251009108 active site 718251009109 catalytic tetrad [active] 718251009110 hypothetical protein; Provisional; Region: PRK01254 718251009111 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 718251009112 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 718251009113 homoserine O-succinyltransferase; Provisional; Region: PRK05368 718251009114 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 718251009115 proposed active site lysine [active] 718251009116 conserved cys residue [active] 718251009117 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 718251009118 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 718251009119 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 718251009120 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 718251009121 trimer interface [polypeptide binding]; other site 718251009122 putative metal binding site [ion binding]; other site 718251009123 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 718251009124 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 718251009125 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 718251009126 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 718251009127 shikimate binding site; other site 718251009128 NAD(P) binding site [chemical binding]; other site 718251009129 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 718251009130 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 718251009131 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 718251009132 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 718251009133 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 718251009134 Protein of unknown function (DUF494); Region: DUF494; cl01103 718251009135 hypothetical protein; Provisional; Region: PRK10736 718251009136 DNA protecting protein DprA; Region: dprA; TIGR00732 718251009137 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 718251009138 active site 718251009139 catalytic residues [active] 718251009140 metal binding site [ion binding]; metal-binding site 718251009141 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 718251009142 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 718251009143 putative active site [active] 718251009144 substrate binding site [chemical binding]; other site 718251009145 putative cosubstrate binding site; other site 718251009146 catalytic site [active] 718251009147 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 718251009148 substrate binding site [chemical binding]; other site 718251009149 16S rRNA methyltransferase B; Provisional; Region: PRK10901 718251009150 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 718251009151 putative RNA binding site [nucleotide binding]; other site 718251009152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251009153 S-adenosylmethionine binding site [chemical binding]; other site 718251009154 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 718251009155 TrkA-N domain; Region: TrkA_N; pfam02254 718251009156 TrkA-C domain; Region: TrkA_C; pfam02080 718251009157 TrkA-N domain; Region: TrkA_N; pfam02254 718251009158 TrkA-C domain; Region: TrkA_C; pfam02080 718251009159 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 718251009160 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 718251009161 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 718251009162 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 718251009163 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 718251009164 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 718251009165 DNA binding residues [nucleotide binding] 718251009166 dimer interface [polypeptide binding]; other site 718251009167 metal binding site [ion binding]; metal-binding site 718251009168 hypothetical protein; Provisional; Region: PRK10203 718251009169 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 718251009170 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 718251009171 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 718251009172 alphaNTD homodimer interface [polypeptide binding]; other site 718251009173 alphaNTD - beta interaction site [polypeptide binding]; other site 718251009174 alphaNTD - beta' interaction site [polypeptide binding]; other site 718251009175 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 718251009176 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 718251009177 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 718251009178 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718251009179 RNA binding surface [nucleotide binding]; other site 718251009180 30S ribosomal protein S11; Validated; Region: PRK05309 718251009181 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 718251009182 30S ribosomal protein S13; Region: bact_S13; TIGR03631 718251009183 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 718251009184 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 718251009185 SecY translocase; Region: SecY; pfam00344 718251009186 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 718251009187 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 718251009188 23S rRNA binding site [nucleotide binding]; other site 718251009189 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 718251009190 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 718251009191 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 718251009192 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 718251009193 23S rRNA interface [nucleotide binding]; other site 718251009194 5S rRNA interface [nucleotide binding]; other site 718251009195 L27 interface [polypeptide binding]; other site 718251009196 L5 interface [polypeptide binding]; other site 718251009197 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 718251009198 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 718251009199 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 718251009200 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 718251009201 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 718251009202 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 718251009203 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 718251009204 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 718251009205 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 718251009206 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 718251009207 RNA binding site [nucleotide binding]; other site 718251009208 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 718251009209 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 718251009210 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 718251009211 23S rRNA interface [nucleotide binding]; other site 718251009212 putative translocon interaction site; other site 718251009213 signal recognition particle (SRP54) interaction site; other site 718251009214 L23 interface [polypeptide binding]; other site 718251009215 trigger factor interaction site; other site 718251009216 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 718251009217 23S rRNA interface [nucleotide binding]; other site 718251009218 5S rRNA interface [nucleotide binding]; other site 718251009219 putative antibiotic binding site [chemical binding]; other site 718251009220 L25 interface [polypeptide binding]; other site 718251009221 L27 interface [polypeptide binding]; other site 718251009222 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 718251009223 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 718251009224 G-X-X-G motif; other site 718251009225 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 718251009226 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 718251009227 protein-rRNA interface [nucleotide binding]; other site 718251009228 putative translocon binding site; other site 718251009229 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 718251009230 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 718251009231 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 718251009232 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 718251009233 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 718251009234 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 718251009235 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 718251009236 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 718251009237 elongation factor Tu; Reviewed; Region: PRK00049 718251009238 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 718251009239 G1 box; other site 718251009240 GEF interaction site [polypeptide binding]; other site 718251009241 GTP/Mg2+ binding site [chemical binding]; other site 718251009242 Switch I region; other site 718251009243 G2 box; other site 718251009244 G3 box; other site 718251009245 Switch II region; other site 718251009246 G4 box; other site 718251009247 G5 box; other site 718251009248 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 718251009249 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 718251009250 Antibiotic Binding Site [chemical binding]; other site 718251009251 elongation factor G; Reviewed; Region: PRK00007 718251009252 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 718251009253 G1 box; other site 718251009254 putative GEF interaction site [polypeptide binding]; other site 718251009255 GTP/Mg2+ binding site [chemical binding]; other site 718251009256 Switch I region; other site 718251009257 G2 box; other site 718251009258 G3 box; other site 718251009259 Switch II region; other site 718251009260 G4 box; other site 718251009261 G5 box; other site 718251009262 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 718251009263 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 718251009264 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 718251009265 30S ribosomal protein S7; Validated; Region: PRK05302 718251009266 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 718251009267 S17 interaction site [polypeptide binding]; other site 718251009268 S8 interaction site; other site 718251009269 16S rRNA interaction site [nucleotide binding]; other site 718251009270 streptomycin interaction site [chemical binding]; other site 718251009271 23S rRNA interaction site [nucleotide binding]; other site 718251009272 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 718251009273 DsrH like protein; Region: DsrH; cl17347 718251009274 sulfur relay protein TusC; Validated; Region: PRK00211 718251009275 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 718251009276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 718251009277 YheO-like PAS domain; Region: PAS_6; pfam08348 718251009278 HTH domain; Region: HTH_22; pfam13309 718251009279 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 718251009280 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 718251009281 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 718251009282 phi X174 lysis protein; Provisional; Region: PRK02793 718251009283 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 718251009284 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 718251009285 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 718251009286 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 718251009287 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 718251009288 TrkA-N domain; Region: TrkA_N; pfam02254 718251009289 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 718251009290 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 718251009291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251009292 Walker A/P-loop; other site 718251009293 ATP binding site [chemical binding]; other site 718251009294 Q-loop/lid; other site 718251009295 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718251009296 ABC transporter; Region: ABC_tran_2; pfam12848 718251009297 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 718251009298 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 718251009299 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 718251009300 inhibitor-cofactor binding pocket; inhibition site 718251009301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251009302 catalytic residue [active] 718251009303 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 718251009304 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 718251009305 glutamine binding [chemical binding]; other site 718251009306 catalytic triad [active] 718251009307 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 718251009308 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 718251009309 substrate binding site [chemical binding]; other site 718251009310 putative transporter; Provisional; Region: PRK03699 718251009311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251009312 putative substrate translocation pore; other site 718251009313 cytosine deaminase; Provisional; Region: PRK09230 718251009314 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 718251009315 active site 718251009316 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 718251009317 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 718251009318 Na binding site [ion binding]; other site 718251009319 putative substrate binding site [chemical binding]; other site 718251009320 siroheme synthase; Provisional; Region: cysG; PRK10637 718251009321 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 718251009322 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 718251009323 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 718251009324 active site 718251009325 SAM binding site [chemical binding]; other site 718251009326 homodimer interface [polypeptide binding]; other site 718251009327 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 718251009328 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 718251009329 active site 718251009330 HIGH motif; other site 718251009331 dimer interface [polypeptide binding]; other site 718251009332 KMSKS motif; other site 718251009333 phosphoglycolate phosphatase; Provisional; Region: PRK13222 718251009334 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 718251009335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251009336 motif II; other site 718251009337 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 718251009338 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 718251009339 substrate binding site [chemical binding]; other site 718251009340 hexamer interface [polypeptide binding]; other site 718251009341 metal binding site [ion binding]; metal-binding site 718251009342 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 718251009343 hypothetical protein; Reviewed; Region: PRK11901 718251009344 cell division protein DamX; Validated; Region: PRK10905 718251009345 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 718251009346 active site 718251009347 dimer interface [polypeptide binding]; other site 718251009348 metal binding site [ion binding]; metal-binding site 718251009349 shikimate kinase; Reviewed; Region: aroK; PRK00131 718251009350 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 718251009351 ADP binding site [chemical binding]; other site 718251009352 magnesium binding site [ion binding]; other site 718251009353 putative shikimate binding site; other site 718251009354 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 718251009355 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 718251009356 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 718251009357 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 718251009358 Transglycosylase; Region: Transgly; pfam00912 718251009359 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 718251009360 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 718251009361 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 718251009362 ADP-ribose binding site [chemical binding]; other site 718251009363 dimer interface [polypeptide binding]; other site 718251009364 active site 718251009365 nudix motif; other site 718251009366 metal binding site [ion binding]; metal-binding site 718251009367 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 718251009368 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 718251009369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251009370 motif II; other site 718251009371 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 718251009372 RNA binding surface [nucleotide binding]; other site 718251009373 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 718251009374 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 718251009375 dimerization interface [polypeptide binding]; other site 718251009376 domain crossover interface; other site 718251009377 redox-dependent activation switch; other site 718251009378 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 718251009379 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 718251009380 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 718251009381 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 718251009382 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 718251009383 active site residue [active] 718251009384 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 718251009385 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 718251009386 active site 718251009387 substrate-binding site [chemical binding]; other site 718251009388 metal-binding site [ion binding] 718251009389 ATP binding site [chemical binding]; other site 718251009390 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 718251009391 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718251009392 dimerization interface [polypeptide binding]; other site 718251009393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251009394 dimer interface [polypeptide binding]; other site 718251009395 phosphorylation site [posttranslational modification] 718251009396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251009397 ATP binding site [chemical binding]; other site 718251009398 Mg2+ binding site [ion binding]; other site 718251009399 G-X-G motif; other site 718251009400 osmolarity response regulator; Provisional; Region: ompR; PRK09468 718251009401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251009402 active site 718251009403 phosphorylation site [posttranslational modification] 718251009404 intermolecular recognition site; other site 718251009405 dimerization interface [polypeptide binding]; other site 718251009406 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718251009407 DNA binding site [nucleotide binding] 718251009408 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 718251009409 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 718251009410 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 718251009411 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 718251009412 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 718251009413 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 718251009414 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 718251009415 RNA binding site [nucleotide binding]; other site 718251009416 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 718251009417 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 718251009418 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 718251009419 G1 box; other site 718251009420 GTP/Mg2+ binding site [chemical binding]; other site 718251009421 Switch I region; other site 718251009422 G2 box; other site 718251009423 G3 box; other site 718251009424 Switch II region; other site 718251009425 G4 box; other site 718251009426 G5 box; other site 718251009427 Nucleoside recognition; Region: Gate; pfam07670 718251009428 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 718251009429 Nucleoside recognition; Region: Gate; pfam07670 718251009430 FeoC like transcriptional regulator; Region: FeoC; cl17677 718251009431 carboxylesterase BioH; Provisional; Region: PRK10349 718251009432 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 718251009433 DNA utilization protein GntX; Provisional; Region: PRK11595 718251009434 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 718251009435 active site 718251009436 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 718251009437 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 718251009438 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 718251009439 transcriptional repressor UlaR; Provisional; Region: PRK13509 718251009440 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 718251009441 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718251009442 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 718251009443 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 718251009444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 718251009445 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 718251009446 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 718251009447 active site 718251009448 phosphorylation site [posttranslational modification] 718251009449 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 718251009450 active site 718251009451 dimer interface [polypeptide binding]; other site 718251009452 magnesium binding site [ion binding]; other site 718251009453 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 718251009454 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 718251009455 AP (apurinic/apyrimidinic) site pocket; other site 718251009456 DNA interaction; other site 718251009457 Metal-binding active site; metal-binding site 718251009458 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 718251009459 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 718251009460 intersubunit interface [polypeptide binding]; other site 718251009461 active site 718251009462 Zn2+ binding site [ion binding]; other site 718251009463 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 718251009464 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 718251009465 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 718251009466 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 718251009467 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 718251009468 ligand binding site [chemical binding]; other site 718251009469 flexible hinge region; other site 718251009470 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 718251009471 putative switch regulator; other site 718251009472 non-specific DNA interactions [nucleotide binding]; other site 718251009473 DNA binding site [nucleotide binding] 718251009474 sequence specific DNA binding site [nucleotide binding]; other site 718251009475 putative cAMP binding site [chemical binding]; other site 718251009476 hypothetical protein; Provisional; Region: PRK04966 718251009477 putative hydrolase; Provisional; Region: PRK10985 718251009478 N terminus of Rad21 / Rec8 like protein; Region: Rad21_Rec8_N; pfam04825 718251009479 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 718251009480 transcriptional regulator MalT; Provisional; Region: PRK04841 718251009481 AAA ATPase domain; Region: AAA_16; pfam13191 718251009482 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718251009483 DNA binding residues [nucleotide binding] 718251009484 dimerization interface [polypeptide binding]; other site 718251009485 maltodextrin phosphorylase; Provisional; Region: PRK14985 718251009486 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 718251009487 homodimer interface [polypeptide binding]; other site 718251009488 active site pocket [active] 718251009489 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 718251009490 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 718251009491 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 718251009492 oligomer interface; other site 718251009493 ligand binding site; other site 718251009494 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 718251009495 N-terminal domain interface [polypeptide binding]; other site 718251009496 sulfate 1 binding site; other site 718251009497 glycogen branching enzyme; Provisional; Region: PRK05402 718251009498 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 718251009499 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 718251009500 active site 718251009501 catalytic site [active] 718251009502 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 718251009503 glycogen debranching enzyme; Provisional; Region: PRK03705 718251009504 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 718251009505 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 718251009506 active site 718251009507 catalytic site [active] 718251009508 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 718251009509 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 718251009510 ligand binding site; other site 718251009511 oligomer interface; other site 718251009512 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 718251009513 dimer interface [polypeptide binding]; other site 718251009514 N-terminal domain interface [polypeptide binding]; other site 718251009515 sulfate 1 binding site; other site 718251009516 glycogen synthase; Provisional; Region: glgA; PRK00654 718251009517 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 718251009518 ADP-binding pocket [chemical binding]; other site 718251009519 homodimer interface [polypeptide binding]; other site 718251009520 glycogen phosphorylase; Provisional; Region: PRK14986 718251009521 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 718251009522 homodimer interface [polypeptide binding]; other site 718251009523 active site pocket [active] 718251009524 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 718251009525 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 718251009526 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 718251009527 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 718251009528 intramembrane serine protease GlpG; Provisional; Region: PRK10907 718251009529 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 718251009530 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 718251009531 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 718251009532 active site residue [active] 718251009533 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 718251009534 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 718251009535 putative active site [active] 718251009536 catalytic site [active] 718251009537 putative metal binding site [ion binding]; other site 718251009538 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 718251009539 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 718251009540 Walker A/P-loop; other site 718251009541 ATP binding site [chemical binding]; other site 718251009542 Q-loop/lid; other site 718251009543 ABC transporter signature motif; other site 718251009544 Walker B; other site 718251009545 D-loop; other site 718251009546 H-loop/switch region; other site 718251009547 TOBE domain; Region: TOBE_2; pfam08402 718251009548 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 718251009549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251009550 dimer interface [polypeptide binding]; other site 718251009551 conserved gate region; other site 718251009552 putative PBP binding loops; other site 718251009553 ABC-ATPase subunit interface; other site 718251009554 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 718251009555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251009556 dimer interface [polypeptide binding]; other site 718251009557 conserved gate region; other site 718251009558 putative PBP binding loops; other site 718251009559 ABC-ATPase subunit interface; other site 718251009560 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 718251009561 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 718251009562 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 718251009563 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 718251009564 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 718251009565 fructuronate transporter; Provisional; Region: PRK10034; cl15264 718251009566 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 718251009567 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 718251009568 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 718251009569 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 718251009570 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 718251009571 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 718251009572 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 718251009573 DNA binding residues [nucleotide binding] 718251009574 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 718251009575 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 718251009576 cell division protein FtsE; Provisional; Region: PRK10908 718251009577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 718251009578 Walker A/P-loop; other site 718251009579 ATP binding site [chemical binding]; other site 718251009580 Q-loop/lid; other site 718251009581 ABC transporter signature motif; other site 718251009582 Walker B; other site 718251009583 D-loop; other site 718251009584 H-loop/switch region; other site 718251009585 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 718251009586 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 718251009587 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 718251009588 P loop; other site 718251009589 GTP binding site [chemical binding]; other site 718251009590 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 718251009591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251009592 S-adenosylmethionine binding site [chemical binding]; other site 718251009593 hypothetical protein; Provisional; Region: PRK10910 718251009594 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 718251009595 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 718251009596 Predicted membrane protein [Function unknown]; Region: COG3714 718251009597 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 718251009598 MOSC domain; Region: MOSC; pfam03473 718251009599 3-alpha domain; Region: 3-alpha; pfam03475 718251009600 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 718251009601 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718251009602 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 718251009603 molybdopterin cofactor binding site; other site 718251009604 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 718251009605 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 718251009606 molybdopterin cofactor binding site; other site 718251009607 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 718251009608 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 718251009609 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 718251009610 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 718251009611 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 718251009612 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 718251009613 putative hydrolase; Provisional; Region: PRK10976 718251009614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251009615 active site 718251009616 motif I; other site 718251009617 motif II; other site 718251009618 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 718251009619 lysophospholipase L2; Provisional; Region: PRK10749 718251009620 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 718251009621 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 718251009622 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 718251009623 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 718251009624 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 718251009625 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 718251009626 Histidine kinase; Region: His_kinase; pfam06580 718251009627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251009628 ATP binding site [chemical binding]; other site 718251009629 Mg2+ binding site [ion binding]; other site 718251009630 G-X-G motif; other site 718251009631 magnesium-transporting ATPase; Provisional; Region: PRK15122 718251009632 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 718251009633 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 718251009634 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 718251009635 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251009636 motif II; other site 718251009637 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 718251009638 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 718251009639 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 718251009640 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 718251009641 Na2 binding site [ion binding]; other site 718251009642 putative substrate binding site 1 [chemical binding]; other site 718251009643 Na binding site 1 [ion binding]; other site 718251009644 putative substrate binding site 2 [chemical binding]; other site 718251009645 universal stress protein UspB; Provisional; Region: PRK04960 718251009646 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 718251009647 Ligand Binding Site [chemical binding]; other site 718251009648 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 718251009649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251009650 putative substrate translocation pore; other site 718251009651 POT family; Region: PTR2; pfam00854 718251009652 glutamate dehydrogenase; Provisional; Region: PRK09414 718251009653 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 718251009654 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 718251009655 NAD(P) binding site [chemical binding]; other site 718251009656 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 718251009657 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 718251009658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251009659 dimer interface [polypeptide binding]; other site 718251009660 phosphorylation site [posttranslational modification] 718251009661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251009662 ATP binding site [chemical binding]; other site 718251009663 Mg2+ binding site [ion binding]; other site 718251009664 G-X-G motif; other site 718251009665 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 718251009666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251009667 active site 718251009668 phosphorylation site [posttranslational modification] 718251009669 intermolecular recognition site; other site 718251009670 dimerization interface [polypeptide binding]; other site 718251009671 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718251009672 DNA binding site [nucleotide binding] 718251009673 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 718251009674 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 718251009675 ligand binding site [chemical binding]; other site 718251009676 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 718251009677 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 718251009678 Walker A/P-loop; other site 718251009679 ATP binding site [chemical binding]; other site 718251009680 Q-loop/lid; other site 718251009681 ABC transporter signature motif; other site 718251009682 Walker B; other site 718251009683 D-loop; other site 718251009684 H-loop/switch region; other site 718251009685 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 718251009686 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718251009687 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 718251009688 TM-ABC transporter signature motif; other site 718251009689 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 718251009690 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 718251009691 TM-ABC transporter signature motif; other site 718251009692 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 718251009693 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 718251009694 N- and C-terminal domain interface [polypeptide binding]; other site 718251009695 active site 718251009696 MgATP binding site [chemical binding]; other site 718251009697 catalytic site [active] 718251009698 metal binding site [ion binding]; metal-binding site 718251009699 carbohydrate binding site [chemical binding]; other site 718251009700 putative homodimer interface [polypeptide binding]; other site 718251009701 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 718251009702 putative active site [active] 718251009703 putative methyltransferase; Provisional; Region: PRK10742 718251009704 oligopeptidase A; Provisional; Region: PRK10911 718251009705 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 718251009706 active site 718251009707 Zn binding site [ion binding]; other site 718251009708 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 718251009709 nucleotide binding site/active site [active] 718251009710 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 718251009711 glutathione reductase; Validated; Region: PRK06116 718251009712 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 718251009713 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718251009714 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 718251009715 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 718251009716 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 718251009717 dimer interface [polypeptide binding]; other site 718251009718 ligand binding site [chemical binding]; other site 718251009719 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 718251009720 dimerization interface [polypeptide binding]; other site 718251009721 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718251009722 dimer interface [polypeptide binding]; other site 718251009723 putative CheW interface [polypeptide binding]; other site 718251009724 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 718251009725 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 718251009726 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 718251009727 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 718251009728 Transcriptional regulator [Transcription]; Region: LysR; COG0583 718251009729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251009730 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 718251009731 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 718251009732 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718251009733 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 718251009734 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 718251009735 substrate binding site [chemical binding]; other site 718251009736 ATP binding site [chemical binding]; other site 718251009737 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 718251009738 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 718251009739 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 718251009740 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 718251009741 biofilm formation regulator HmsP; Provisional; Region: PRK11829 718251009742 HAMP domain; Region: HAMP; pfam00672 718251009743 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 718251009744 metal binding site [ion binding]; metal-binding site 718251009745 active site 718251009746 I-site; other site 718251009747 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 718251009748 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 718251009749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718251009750 binding surface 718251009751 TPR motif; other site 718251009752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 718251009753 TPR motif; other site 718251009754 binding surface 718251009755 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 718251009756 endo-1,4-D-glucanase; Provisional; Region: PRK11097 718251009757 cellulose synthase regulator protein; Provisional; Region: PRK11114 718251009758 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 718251009759 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 718251009760 DXD motif; other site 718251009761 Cellulose synthase-like protein; Region: PLN02893 718251009762 PilZ domain; Region: PilZ; pfam07238 718251009763 YhjQ protein; Region: YhjQ; pfam06564 718251009764 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 718251009765 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 718251009766 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 718251009767 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 718251009768 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 718251009769 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718251009770 Walker A/P-loop; other site 718251009771 ATP binding site [chemical binding]; other site 718251009772 Q-loop/lid; other site 718251009773 ABC transporter signature motif; other site 718251009774 Walker B; other site 718251009775 D-loop; other site 718251009776 H-loop/switch region; other site 718251009777 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 718251009778 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 718251009779 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 718251009780 Walker A/P-loop; other site 718251009781 ATP binding site [chemical binding]; other site 718251009782 Q-loop/lid; other site 718251009783 ABC transporter signature motif; other site 718251009784 Walker B; other site 718251009785 D-loop; other site 718251009786 H-loop/switch region; other site 718251009787 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 718251009788 dipeptide transporter; Provisional; Region: PRK10913 718251009789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251009790 putative PBP binding loops; other site 718251009791 dimer interface [polypeptide binding]; other site 718251009792 ABC-ATPase subunit interface; other site 718251009793 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 718251009794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251009795 dimer interface [polypeptide binding]; other site 718251009796 conserved gate region; other site 718251009797 putative PBP binding loops; other site 718251009798 ABC-ATPase subunit interface; other site 718251009799 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 718251009800 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 718251009801 peptide binding site [polypeptide binding]; other site 718251009802 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 718251009803 putative deacylase active site [active] 718251009804 regulatory protein UhpC; Provisional; Region: PRK11663 718251009805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251009806 putative substrate translocation pore; other site 718251009807 sensory histidine kinase UhpB; Provisional; Region: PRK11644 718251009808 MASE1; Region: MASE1; cl17823 718251009809 MASE1; Region: MASE1; pfam05231 718251009810 Histidine kinase; Region: HisKA_3; pfam07730 718251009811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251009812 ATP binding site [chemical binding]; other site 718251009813 Mg2+ binding site [ion binding]; other site 718251009814 G-X-G motif; other site 718251009815 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 718251009816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251009817 active site 718251009818 phosphorylation site [posttranslational modification] 718251009819 intermolecular recognition site; other site 718251009820 dimerization interface [polypeptide binding]; other site 718251009821 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 718251009822 DNA binding residues [nucleotide binding] 718251009823 dimerization interface [polypeptide binding]; other site 718251009824 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 718251009825 ligand binding site [chemical binding]; other site 718251009826 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 718251009827 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 718251009828 dimerization interface [polypeptide binding]; other site 718251009829 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 718251009830 dimer interface [polypeptide binding]; other site 718251009831 putative CheW interface [polypeptide binding]; other site 718251009832 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 718251009833 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 718251009834 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 718251009835 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 718251009836 active site 718251009837 metal binding site [ion binding]; metal-binding site 718251009838 nudix motif; other site 718251009839 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 718251009840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 718251009841 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 718251009842 Ligand Binding Site [chemical binding]; other site 718251009843 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 718251009844 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 718251009845 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 718251009846 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 718251009847 putative catalytic residues [active] 718251009848 putative nucleotide binding site [chemical binding]; other site 718251009849 putative aspartate binding site [chemical binding]; other site 718251009850 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 718251009851 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 718251009852 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 718251009853 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 718251009854 homodimer interface [polypeptide binding]; other site 718251009855 substrate-cofactor binding pocket; other site 718251009856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 718251009857 catalytic residue [active] 718251009858 transcriptional repressor protein MetJ; Provisional; Region: PRK05264 718251009859 dimerization interface [polypeptide binding]; other site 718251009860 DNA binding site [nucleotide binding] 718251009861 corepressor binding sites; other site 718251009862 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 718251009863 primosome assembly protein PriA; Validated; Region: PRK05580 718251009864 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 718251009865 ATP binding site [chemical binding]; other site 718251009866 putative Mg++ binding site [ion binding]; other site 718251009867 helicase superfamily c-terminal domain; Region: HELICc; smart00490 718251009868 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718251009869 DNA binding site [nucleotide binding] 718251009870 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 718251009871 domain linker motif; other site 718251009872 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 718251009873 dimerization interface [polypeptide binding]; other site 718251009874 ligand binding site [chemical binding]; other site 718251009875 essential cell division protein FtsN; Provisional; Region: PRK10927 718251009876 cell division protein FtsN; Provisional; Region: PRK12757 718251009877 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 718251009878 active site 718251009879 HslU subunit interaction site [polypeptide binding]; other site 718251009880 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 718251009881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251009882 Walker A motif; other site 718251009883 ATP binding site [chemical binding]; other site 718251009884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251009885 Walker B motif; other site 718251009886 arginine finger; other site 718251009887 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 718251009888 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 718251009889 UbiA prenyltransferase family; Region: UbiA; pfam01040 718251009890 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 718251009891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 718251009892 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 718251009893 amphipathic channel; other site 718251009894 Asn-Pro-Ala signature motifs; other site 718251009895 glycerol kinase; Provisional; Region: glpK; PRK00047 718251009896 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 718251009897 N- and C-terminal domain interface [polypeptide binding]; other site 718251009898 active site 718251009899 MgATP binding site [chemical binding]; other site 718251009900 catalytic site [active] 718251009901 metal binding site [ion binding]; metal-binding site 718251009902 glycerol binding site [chemical binding]; other site 718251009903 homotetramer interface [polypeptide binding]; other site 718251009904 homodimer interface [polypeptide binding]; other site 718251009905 FBP binding site [chemical binding]; other site 718251009906 protein IIAGlc interface [polypeptide binding]; other site 718251009907 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 718251009908 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 718251009909 putative active site [active] 718251009910 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 718251009911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251009912 putative substrate translocation pore; other site 718251009913 Predicted transcriptional regulator [Transcription]; Region: COG2345 718251009914 ferredoxin-NADP reductase; Provisional; Region: PRK10926 718251009915 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 718251009916 FAD binding pocket [chemical binding]; other site 718251009917 FAD binding motif [chemical binding]; other site 718251009918 phosphate binding motif [ion binding]; other site 718251009919 beta-alpha-beta structure motif; other site 718251009920 NAD binding pocket [chemical binding]; other site 718251009921 Predicted membrane protein [Function unknown]; Region: COG3152 718251009922 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 718251009923 triosephosphate isomerase; Provisional; Region: PRK14567 718251009924 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 718251009925 substrate binding site [chemical binding]; other site 718251009926 dimer interface [polypeptide binding]; other site 718251009927 catalytic triad [active] 718251009928 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 718251009929 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 718251009930 active site 718251009931 ADP/pyrophosphate binding site [chemical binding]; other site 718251009932 dimerization interface [polypeptide binding]; other site 718251009933 allosteric effector site; other site 718251009934 fructose-1,6-bisphosphate binding site; other site 718251009935 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 718251009936 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 718251009937 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 718251009938 dimer interface [polypeptide binding]; other site 718251009939 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 718251009940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251009941 active site 718251009942 phosphorylation site [posttranslational modification] 718251009943 intermolecular recognition site; other site 718251009944 dimerization interface [polypeptide binding]; other site 718251009945 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 718251009946 DNA binding site [nucleotide binding] 718251009947 two-component sensor protein; Provisional; Region: cpxA; PRK09470 718251009948 HAMP domain; Region: HAMP; pfam00672 718251009949 dimerization interface [polypeptide binding]; other site 718251009950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251009951 dimer interface [polypeptide binding]; other site 718251009952 phosphorylation site [posttranslational modification] 718251009953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251009954 ATP binding site [chemical binding]; other site 718251009955 Mg2+ binding site [ion binding]; other site 718251009956 G-X-G motif; other site 718251009957 putative rRNA methylase; Provisional; Region: PRK10358 718251009958 serine acetyltransferase; Provisional; Region: cysE; PRK11132 718251009959 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 718251009960 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 718251009961 trimer interface [polypeptide binding]; other site 718251009962 active site 718251009963 substrate binding site [chemical binding]; other site 718251009964 CoA binding site [chemical binding]; other site 718251009965 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 718251009966 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 718251009967 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 718251009968 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 718251009969 SecA binding site; other site 718251009970 Preprotein binding site; other site 718251009971 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 718251009972 GSH binding site [chemical binding]; other site 718251009973 catalytic residues [active] 718251009974 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 718251009975 active site residue [active] 718251009976 phosphoglyceromutase; Provisional; Region: PRK05434 718251009977 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 718251009978 AmiB activator; Provisional; Region: PRK11637 718251009979 Peptidase family M23; Region: Peptidase_M23; pfam01551 718251009980 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 718251009981 NodB motif; other site 718251009982 putative active site [active] 718251009983 putative catalytic site [active] 718251009984 Zn binding site [ion binding]; other site 718251009985 hypothetical protein; Provisional; Region: PRK11027 718251009986 transcriptional regulator HdfR; Provisional; Region: PRK03601 718251009987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251009988 LysR substrate binding domain; Region: LysR_substrate; pfam03466 718251009989 dimerization interface [polypeptide binding]; other site 718251009990 glutamate racemase; Provisional; Region: PRK00865 718251009991 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 718251009992 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 718251009993 N-terminal plug; other site 718251009994 ligand-binding site [chemical binding]; other site 718251009995 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251009996 active site 718251009997 motif I; other site 718251009998 motif II; other site 718251009999 acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009 718251010000 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 718251010001 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 718251010002 eyelet of channel; other site 718251010003 trimer interface [polypeptide binding]; other site 718251010004 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 718251010005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251010006 S-adenosylmethionine binding site [chemical binding]; other site 718251010007 Protein of unknown function (DUF1422); Region: DUF1422; cl11649 718251010008 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 718251010009 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718251010010 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 718251010011 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718251010012 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 718251010013 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 718251010014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 718251010015 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 718251010016 dimerization interface [polypeptide binding]; other site 718251010017 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 718251010018 catalytic triad [active] 718251010019 dimer interface [polypeptide binding]; other site 718251010020 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 718251010021 GSH binding site [chemical binding]; other site 718251010022 catalytic residues [active] 718251010023 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 718251010024 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 718251010025 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 718251010026 argininosuccinate lyase; Provisional; Region: PRK04833 718251010027 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 718251010028 active sites [active] 718251010029 tetramer interface [polypeptide binding]; other site 718251010030 argininosuccinate synthase; Provisional; Region: PRK13820 718251010031 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 718251010032 ANP binding site [chemical binding]; other site 718251010033 Substrate Binding Site II [chemical binding]; other site 718251010034 Substrate Binding Site I [chemical binding]; other site 718251010035 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 718251010036 nucleotide binding site [chemical binding]; other site 718251010037 N-acetyl-L-glutamate binding site [chemical binding]; other site 718251010038 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 718251010039 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 718251010040 acetylornithine deacetylase; Provisional; Region: PRK05111 718251010041 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 718251010042 metal binding site [ion binding]; metal-binding site 718251010043 putative dimer interface [polypeptide binding]; other site 718251010044 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 718251010045 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 718251010046 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 718251010047 FAD binding site [chemical binding]; other site 718251010048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 718251010049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 718251010050 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 718251010051 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 718251010052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251010053 putative substrate translocation pore; other site 718251010054 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 718251010055 putative active site [active] 718251010056 dimerization interface [polypeptide binding]; other site 718251010057 putative tRNAtyr binding site [nucleotide binding]; other site 718251010058 hypothetical protein; Reviewed; Region: PRK01637 718251010059 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 718251010060 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 718251010061 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 718251010062 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 718251010063 G1 box; other site 718251010064 putative GEF interaction site [polypeptide binding]; other site 718251010065 GTP/Mg2+ binding site [chemical binding]; other site 718251010066 Switch I region; other site 718251010067 G2 box; other site 718251010068 G3 box; other site 718251010069 Switch II region; other site 718251010070 G4 box; other site 718251010071 G5 box; other site 718251010072 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 718251010073 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 718251010074 glutamine synthetase; Provisional; Region: glnA; PRK09469 718251010075 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 718251010076 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 718251010077 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 718251010078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 718251010079 dimer interface [polypeptide binding]; other site 718251010080 phosphorylation site [posttranslational modification] 718251010081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 718251010082 ATP binding site [chemical binding]; other site 718251010083 Mg2+ binding site [ion binding]; other site 718251010084 G-X-G motif; other site 718251010085 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 718251010086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 718251010087 active site 718251010088 phosphorylation site [posttranslational modification] 718251010089 intermolecular recognition site; other site 718251010090 dimerization interface [polypeptide binding]; other site 718251010091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251010092 Walker A motif; other site 718251010093 ATP binding site [chemical binding]; other site 718251010094 Walker B motif; other site 718251010095 arginine finger; other site 718251010096 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 718251010097 putative transporter; Validated; Region: PRK03818 718251010098 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 718251010099 TrkA-C domain; Region: TrkA_C; pfam02080 718251010100 TrkA-C domain; Region: TrkA_C; pfam02080 718251010101 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 718251010102 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 718251010103 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 718251010104 FeS/SAM binding site; other site 718251010105 HemN C-terminal domain; Region: HemN_C; pfam06969 718251010106 Der GTPase activator; Provisional; Region: PRK05244 718251010107 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 718251010108 G1 box; other site 718251010109 GTP/Mg2+ binding site [chemical binding]; other site 718251010110 Switch I region; other site 718251010111 G2 box; other site 718251010112 G3 box; other site 718251010113 Switch II region; other site 718251010114 G4 box; other site 718251010115 G5 box; other site 718251010116 DNA polymerase I; Provisional; Region: PRK05755 718251010117 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 718251010118 active site 718251010119 metal binding site 1 [ion binding]; metal-binding site 718251010120 putative 5' ssDNA interaction site; other site 718251010121 metal binding site 3; metal-binding site 718251010122 metal binding site 2 [ion binding]; metal-binding site 718251010123 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 718251010124 putative DNA binding site [nucleotide binding]; other site 718251010125 putative metal binding site [ion binding]; other site 718251010126 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 718251010127 active site 718251010128 catalytic site [active] 718251010129 substrate binding site [chemical binding]; other site 718251010130 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 718251010131 active site 718251010132 DNA binding site [nucleotide binding] 718251010133 catalytic site [active] 718251010134 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 718251010135 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 718251010136 putative acyl-acceptor binding pocket; other site 718251010137 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 718251010138 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 718251010139 catalytic residues [active] 718251010140 hinge region; other site 718251010141 alpha helical domain; other site 718251010142 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 718251010143 serine/threonine protein kinase; Provisional; Region: PRK11768 718251010144 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 718251010145 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 718251010146 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 718251010147 GTP binding site; other site 718251010148 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 718251010149 Walker A motif; other site 718251010150 Transcriptional regulators [Transcription]; Region: FadR; COG2186 718251010151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 718251010152 DNA-binding site [nucleotide binding]; DNA binding site 718251010153 FCD domain; Region: FCD; pfam07729 718251010154 putative transporter; Provisional; Region: PRK10504 718251010155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 718251010156 transcriptional repressor RbsR; Provisional; Region: PRK10423 718251010157 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 718251010158 DNA binding site [nucleotide binding] 718251010159 domain linker motif; other site 718251010160 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 718251010161 dimerization interface [polypeptide binding]; other site 718251010162 ligand binding site [chemical binding]; other site 718251010163 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 718251010164 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 718251010165 substrate binding site [chemical binding]; other site 718251010166 dimer interface [polypeptide binding]; other site 718251010167 ATP binding site [chemical binding]; other site 718251010168 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 718251010169 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 718251010170 ligand binding site [chemical binding]; other site 718251010171 dimerization interface [polypeptide binding]; other site 718251010172 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 718251010173 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 718251010174 TM-ABC transporter signature motif; other site 718251010175 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 718251010176 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 718251010177 Walker A/P-loop; other site 718251010178 ATP binding site [chemical binding]; other site 718251010179 Q-loop/lid; other site 718251010180 ABC transporter signature motif; other site 718251010181 Walker B; other site 718251010182 D-loop; other site 718251010183 H-loop/switch region; other site 718251010184 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 718251010185 D-ribose pyranase; Provisional; Region: PRK11797 718251010186 potassium uptake protein; Region: kup; TIGR00794 718251010187 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 718251010188 regulatory ATPase RavA; Provisional; Region: PRK13531 718251010189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 718251010190 Walker A motif; other site 718251010191 ATP binding site [chemical binding]; other site 718251010192 Walker B motif; other site 718251010193 arginine finger; other site 718251010194 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 718251010195 hypothetical protein; Provisional; Region: yieM; PRK10997 718251010196 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 718251010197 metal ion-dependent adhesion site (MIDAS); other site 718251010198 asparagine synthetase AsnA; Provisional; Region: PRK05425 718251010199 motif 1; other site 718251010200 dimer interface [polypeptide binding]; other site 718251010201 active site 718251010202 motif 2; other site 718251010203 motif 3; other site 718251010204 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 718251010205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 718251010206 putative DNA binding site [nucleotide binding]; other site 718251010207 putative Zn2+ binding site [ion binding]; other site 718251010208 AsnC family; Region: AsnC_trans_reg; pfam01037 718251010209 FMN-binding protein MioC; Provisional; Region: PRK09004 718251010210 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 718251010211 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 718251010212 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 718251010213 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 718251010214 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 718251010215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 718251010216 S-adenosylmethionine binding site [chemical binding]; other site 718251010217 ATP synthase I chain; Region: ATP_synt_I; cl09170 718251010218 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 718251010219 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 718251010220 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 718251010221 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 718251010222 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 718251010223 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 718251010224 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 718251010225 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 718251010226 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 718251010227 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 718251010228 Walker A motif; other site 718251010229 ATP binding site [chemical binding]; other site 718251010230 Walker B motif; other site 718251010231 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 718251010232 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 718251010233 core domain interface [polypeptide binding]; other site 718251010234 delta subunit interface [polypeptide binding]; other site 718251010235 epsilon subunit interface [polypeptide binding]; other site 718251010236 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 718251010237 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 718251010238 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 718251010239 alpha subunit interaction interface [polypeptide binding]; other site 718251010240 Walker A motif; other site 718251010241 ATP binding site [chemical binding]; other site 718251010242 Walker B motif; other site 718251010243 inhibitor binding site; inhibition site 718251010244 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 718251010245 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 718251010246 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 718251010247 gamma subunit interface [polypeptide binding]; other site 718251010248 epsilon subunit interface [polypeptide binding]; other site 718251010249 LBP interface [polypeptide binding]; other site 718251010250 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 718251010251 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 718251010252 Substrate binding site; other site 718251010253 Mg++ binding site; other site 718251010254 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 718251010255 active site 718251010256 substrate binding site [chemical binding]; other site 718251010257 CoA binding site [chemical binding]; other site 718251010258 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 718251010259 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 718251010260 glutaminase active site [active] 718251010261 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 718251010262 dimer interface [polypeptide binding]; other site 718251010263 active site 718251010264 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 718251010265 dimer interface [polypeptide binding]; other site 718251010266 active site 718251010267 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 718251010268 active site 718251010269 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 718251010270 substrate binding pocket [chemical binding]; other site 718251010271 membrane-bound complex binding site; other site 718251010272 hinge residues; other site 718251010273 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 718251010274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251010275 dimer interface [polypeptide binding]; other site 718251010276 conserved gate region; other site 718251010277 putative PBP binding loops; other site 718251010278 ABC-ATPase subunit interface; other site 718251010279 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 718251010280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 718251010281 dimer interface [polypeptide binding]; other site 718251010282 conserved gate region; other site 718251010283 putative PBP binding loops; other site 718251010284 ABC-ATPase subunit interface; other site 718251010285 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 718251010286 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 718251010287 Walker A/P-loop; other site 718251010288 ATP binding site [chemical binding]; other site 718251010289 Q-loop/lid; other site 718251010290 ABC transporter signature motif; other site 718251010291 Walker B; other site 718251010292 D-loop; other site 718251010293 H-loop/switch region; other site 718251010294 transcriptional regulator PhoU; Provisional; Region: PRK11115 718251010295 PhoU domain; Region: PhoU; pfam01895 718251010296 PhoU domain; Region: PhoU; pfam01895 718251010297 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 718251010298 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 718251010299 motif II; other site 718251010300 cryptic adenine deaminase; Provisional; Region: PRK10027 718251010301 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 718251010302 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 718251010303 active site 718251010304 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 718251010305 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 718251010306 Predicted peptidase [General function prediction only]; Region: COG4099 718251010307 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 718251010308 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 718251010309 Uncharacterized conserved protein [Function unknown]; Region: COG0398 718251010310 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 718251010311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 718251010312 Smr domain; Region: Smr; pfam01713 718251010313 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 718251010314 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 718251010315 trmE is a tRNA modification GTPase; Region: trmE; cd04164 718251010316 G1 box; other site 718251010317 GTP/Mg2+ binding site [chemical binding]; other site 718251010318 Switch I region; other site 718251010319 G2 box; other site 718251010320 Switch II region; other site 718251010321 G3 box; other site 718251010322 G4 box; other site 718251010323 G5 box; other site 718251010324 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 718251010325 membrane protein insertase; Provisional; Region: PRK01318 718251010326 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 718251010327 hypothetical protein; Validated; Region: PRK00041 718251010328 Ribonuclease P; Region: Ribonuclease_P; cl00457 718251010329 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 718251010330 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 718251010331 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 718251010332 oligomer interface [polypeptide binding]; other site 718251010333 active site residues [active] 718251010334 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 718251010335 Uncharacterized conserved protein [Function unknown]; Region: COG5471 718251010336 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 718251010337 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 718251010338 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 718251010339 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 718251010340 Phage major tail protein 2; Region: Phage_tail_2; cl11463 718251010341 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 718251010342 Minor tail protein T; Region: Phage_tail_T; cl05636 718251010343 Phage-related minor tail protein [Function unknown]; Region: COG5281 718251010344 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 718251010345 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 718251010346 Phage-related protein [Function unknown]; Region: COG4718 718251010347 Phage-related protein [Function unknown]; Region: gp18; COG4672 718251010348 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 718251010349 MPN+ (JAMM) motif; other site 718251010350 Zinc-binding site [ion binding]; other site 718251010351 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 718251010352 NlpC/P60 family; Region: NLPC_P60; cl17555 718251010353 Phage-related protein, tail component [Function unknown]; Region: COG4723 718251010354 Phage-related protein, tail component [Function unknown]; Region: COG4733 718251010355 Putative phage tail protein; Region: Phage-tail_3; pfam13550 718251010356 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 718251010357 Interdomain contacts; other site 718251010358 Cytokine receptor motif; other site 718251010359 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 718251010360 Interdomain contacts; other site 718251010361 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 718251010362 Cytokine receptor motif; other site 718251010363 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 718251010364 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 718251010365 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 718251010366 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 718251010367 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 718251010368 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 718251010369 active site 718251010370 Int/Topo IB signature motif; other site 718251010371 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 718251010372 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 718251010373 Methyltransferase domain; Region: Methyltransf_25; pfam13649 718251010374 recombination associated protein; Reviewed; Region: rdgC; PRK00321 718251010375 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 718251010376 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718251010377 non-specific DNA binding site [nucleotide binding]; other site 718251010378 salt bridge; other site 718251010379 sequence-specific DNA binding site [nucleotide binding]; other site 718251010380 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 718251010381 non-specific DNA binding site [nucleotide binding]; other site 718251010382 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 718251010383 salt bridge; other site 718251010384 sequence-specific DNA binding site [nucleotide binding]; other site 718251010385 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 718251010386 Catalytic site [active] 718251010387 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 718251010388 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 718251010389 Helix-turn-helix domain; Region: HTH_36; pfam13730 718251010390 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 718251010391 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 718251010392 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 718251010393 Protein of unknown function (DUF968); Region: DUF968; pfam06147 718251010394 Protein of unknown function (DUF754); Region: DUF754; pfam05449 718251010395 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 718251010396 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 718251010397 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 718251010398 AntA/AntB antirepressor; Region: AntA; cl01430 718251010399 Zinc knuckle; Region: zf-CCHC_4; pfam14392 718251010400 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 718251010401 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 718251010402 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 718251010403 phage portal protein, lambda family; Region: portal_lambda; TIGR01539