-- dump date   	20140619_070303
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
502558000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
502558000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
502558000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558000004	Walker A motif; other site
502558000005	ATP binding site [chemical binding]; other site
502558000006	Walker B motif; other site
502558000007	arginine finger; other site
502558000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
502558000009	DnaA box-binding interface [nucleotide binding]; other site
502558000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
502558000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
502558000012	putative DNA binding surface [nucleotide binding]; other site
502558000013	dimer interface [polypeptide binding]; other site
502558000014	beta-clamp/clamp loader binding surface; other site
502558000015	beta-clamp/translesion DNA polymerase binding surface; other site
502558000016	recombination protein F; Reviewed; Region: recF; PRK00064
502558000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558000018	Walker A/P-loop; other site
502558000019	ATP binding site [chemical binding]; other site
502558000020	Q-loop/lid; other site
502558000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558000022	ABC transporter signature motif; other site
502558000023	Walker B; other site
502558000024	D-loop; other site
502558000025	H-loop/switch region; other site
502558000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
502558000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558000028	Mg2+ binding site [ion binding]; other site
502558000029	G-X-G motif; other site
502558000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
502558000031	anchoring element; other site
502558000032	dimer interface [polypeptide binding]; other site
502558000033	ATP binding site [chemical binding]; other site
502558000034	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
502558000035	active site
502558000036	putative metal-binding site [ion binding]; other site
502558000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
502558000038	DNA gyrase subunit A; Validated; Region: PRK05560
502558000039	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
502558000040	CAP-like domain; other site
502558000041	active site
502558000042	primary dimer interface [polypeptide binding]; other site
502558000043	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
502558000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
502558000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
502558000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
502558000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
502558000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
502558000049	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
502558000050	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
502558000051	Bifunctional nuclease; Region: DNase-RNase; pfam02577
502558000052	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
502558000053	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558000054	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
502558000055	dimerization interface [polypeptide binding]; other site
502558000056	ribonuclease E; Reviewed; Region: rne; PRK10811
502558000057	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
502558000058	Putative viral replication protein; Region: Viral_Rep; pfam02407
502558000059	RNA helicase; Region: RNA_helicase; pfam00910
502558000060	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
502558000061	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
502558000062	catalytic residues [active]
502558000063	catalytic nucleophile [active]
502558000064	Recombinase; Region: Recombinase; pfam07508
502558000065	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
502558000066	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
502558000067	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
502558000068	catalytic residues [active]
502558000069	catalytic nucleophile [active]
502558000070	Recombinase; Region: Recombinase; pfam07508
502558000071	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
502558000072	PemK-like protein; Region: PemK; pfam02452
502558000073	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
502558000074	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
502558000075	Transposase; Region: DEDD_Tnp_IS110; pfam01548
502558000076	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
502558000077	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
502558000078	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
502558000079	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
502558000080	acyl-activating enzyme (AAE) consensus motif; other site
502558000081	active site
502558000082	AMP binding site [chemical binding]; other site
502558000083	substrate binding site [chemical binding]; other site
502558000084	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
502558000085	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
502558000086	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
502558000087	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
502558000088	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
502558000089	Walker A/P-loop; other site
502558000090	ATP binding site [chemical binding]; other site
502558000091	Q-loop/lid; other site
502558000092	ABC transporter signature motif; other site
502558000093	Walker B; other site
502558000094	D-loop; other site
502558000095	H-loop/switch region; other site
502558000096	Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226
502558000097	Walker A/P-loop; other site
502558000098	ATP binding site [chemical binding]; other site
502558000099	Q-loop/lid; other site
502558000100	ABC transporter signature motif; other site
502558000101	Walker B; other site
502558000102	D-loop; other site
502558000103	H-loop/switch region; other site
502558000104	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
502558000105	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
502558000106	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
502558000107	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558000108	Walker A/P-loop; other site
502558000109	ATP binding site [chemical binding]; other site
502558000110	Q-loop/lid; other site
502558000111	ABC transporter signature motif; other site
502558000112	Walker B; other site
502558000113	D-loop; other site
502558000114	H-loop/switch region; other site
502558000115	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
502558000116	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
502558000117	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558000118	Walker A/P-loop; other site
502558000119	ATP binding site [chemical binding]; other site
502558000120	Q-loop/lid; other site
502558000121	ABC transporter signature motif; other site
502558000122	Walker B; other site
502558000123	D-loop; other site
502558000124	H-loop/switch region; other site
502558000125	Nonribosomal peptide synthase; Region: NRPS; pfam08415
502558000126	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
502558000127	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
502558000128	acyl-activating enzyme (AAE) consensus motif; other site
502558000129	AMP binding site [chemical binding]; other site
502558000130	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
502558000131	Condensation domain; Region: Condensation; pfam00668
502558000132	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
502558000133	Nonribosomal peptide synthase; Region: NRPS; pfam08415
502558000134	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
502558000135	acyl-activating enzyme (AAE) consensus motif; other site
502558000136	AMP binding site [chemical binding]; other site
502558000137	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
502558000138	Condensation domain; Region: Condensation; pfam00668
502558000139	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
502558000140	Nonribosomal peptide synthase; Region: NRPS; pfam08415
502558000141	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
502558000142	Condensation domain; Region: Condensation; pfam00668
502558000143	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
502558000144	Nonribosomal peptide synthase; Region: NRPS; pfam08415
502558000145	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
502558000146	Condensation domain; Region: Condensation; pfam00668
502558000147	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
502558000148	Nonribosomal peptide synthase; Region: NRPS; pfam08415
502558000149	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
502558000150	acyl-activating enzyme (AAE) consensus motif; other site
502558000151	AMP binding site [chemical binding]; other site
502558000152	Methyltransferase domain; Region: Methyltransf_31; pfam13847
502558000153	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
502558000154	S-adenosylmethionine binding site [chemical binding]; other site
502558000155	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558000156	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
502558000157	thiazolinyl imide reductase; Region: thiaz-red; TIGR01761
502558000158	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
502558000159	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558000160	putative substrate translocation pore; other site
502558000161	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
502558000162	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
502558000163	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
502558000164	CHAP domain; Region: CHAP; cl17642
502558000165	Domain of unknown function DUF87; Region: DUF87; pfam01935
502558000166	AAA-like domain; Region: AAA_10; pfam12846
502558000167	PrgI family protein; Region: PrgI; pfam12666
502558000168	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
502558000169	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
502558000170	Walker A motif; other site
502558000171	ATP binding site [chemical binding]; other site
502558000172	Walker B motif; other site
502558000173	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
502558000174	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
502558000175	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
502558000176	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
502558000177	Toprim-like; Region: Toprim_2; pfam13155
502558000178	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
502558000179	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
502558000180	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
502558000181	cofactor binding site; other site
502558000182	DNA binding site [nucleotide binding]
502558000183	substrate interaction site [chemical binding]; other site
502558000184	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
502558000185	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
502558000186	cofactor binding site; other site
502558000187	DNA binding site [nucleotide binding]
502558000188	substrate interaction site [chemical binding]; other site
502558000189	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
502558000190	RelB antitoxin; Region: RelB; cl01171
502558000191	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
502558000192	S-adenosylmethionine binding site [chemical binding]; other site
502558000193	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
502558000194	DEAD-like helicases superfamily; Region: DEXDc; smart00487
502558000195	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
502558000196	helicase superfamily c-terminal domain; Region: HELICc; smart00490
502558000197	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
502558000198	NlpC/P60 family; Region: NLPC_P60; cl17555
502558000199	Cna protein B-type domain; Region: Cna_B; pfam05738
502558000200	Cna protein B-type domain; Region: Cna_B; pfam05738
502558000201	Cna protein B-type domain; Region: Cna_B; pfam05738
502558000202	Cna protein B-type domain; Region: Cna_B; pfam05738
502558000203	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
502558000204	active site
502558000205	catalytic site [active]
502558000206	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
502558000207	ParB-like nuclease domain; Region: ParBc; pfam02195
502558000208	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
502558000209	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
502558000210	P-loop; other site
502558000211	Magnesium ion binding site [ion binding]; other site
502558000212	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
502558000213	Magnesium ion binding site [ion binding]; other site
502558000214	Cna protein B-type domain; Region: Cna_B; pfam05738
502558000215	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
502558000216	domain interaction interfaces [polypeptide binding]; other site
502558000217	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
502558000218	domain interaction interfaces [polypeptide binding]; other site
502558000219	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
502558000220	domain interaction interfaces [polypeptide binding]; other site
502558000221	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
502558000222	domain interaction interfaces [polypeptide binding]; other site
502558000223	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
502558000224	domain interaction interfaces [polypeptide binding]; other site
502558000225	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
502558000226	domain interaction interfaces [polypeptide binding]; other site
502558000227	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
502558000228	domain interaction interfaces [polypeptide binding]; other site
502558000229	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
502558000230	domain interaction interfaces [polypeptide binding]; other site
502558000231	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
502558000232	domain interaction interfaces [polypeptide binding]; other site
502558000233	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
502558000234	domain interaction interfaces [polypeptide binding]; other site
502558000235	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
502558000236	domain interaction interfaces [polypeptide binding]; other site
502558000237	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
502558000238	domain interaction interfaces [polypeptide binding]; other site
502558000239	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
502558000240	HSP70 interaction site [polypeptide binding]; other site
502558000241	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
502558000242	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
502558000243	G1 box; other site
502558000244	putative GEF interaction site [polypeptide binding]; other site
502558000245	GTP/Mg2+ binding site [chemical binding]; other site
502558000246	Switch I region; other site
502558000247	G2 box; other site
502558000248	G3 box; other site
502558000249	Switch II region; other site
502558000250	G4 box; other site
502558000251	G5 box; other site
502558000252	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
502558000253	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
502558000254	SurA N-terminal domain; Region: SurA_N_3; cl07813
502558000255	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
502558000256	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
502558000257	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558000258	Walker A/P-loop; other site
502558000259	ATP binding site [chemical binding]; other site
502558000260	Q-loop/lid; other site
502558000261	ABC transporter signature motif; other site
502558000262	Walker B; other site
502558000263	D-loop; other site
502558000264	H-loop/switch region; other site
502558000265	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
502558000266	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
502558000267	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
502558000268	dimer interface [polypeptide binding]; other site
502558000269	ssDNA binding site [nucleotide binding]; other site
502558000270	tetramer (dimer of dimers) interface [polypeptide binding]; other site
502558000271	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
502558000272	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
502558000273	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
502558000274	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
502558000275	replicative DNA helicase; Region: DnaB; TIGR00665
502558000276	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
502558000277	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
502558000278	Walker A motif; other site
502558000279	ATP binding site [chemical binding]; other site
502558000280	Walker B motif; other site
502558000281	DNA binding loops [nucleotide binding]
502558000282	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
502558000283	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
502558000284	active site
502558000285	metal binding site [ion binding]; metal-binding site
502558000286	DNA binding site [nucleotide binding]
502558000287	AAA domain; Region: AAA_23; pfam13476
502558000288	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558000289	Walker A/P-loop; other site
502558000290	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558000291	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558000292	DNA binding residues [nucleotide binding]
502558000293	dimerization interface [polypeptide binding]; other site
502558000294	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558000295	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558000296	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
502558000297	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
502558000298	GDP-binding site [chemical binding]; other site
502558000299	ACT binding site; other site
502558000300	IMP binding site; other site
502558000301	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
502558000302	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
502558000303	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
502558000304	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
502558000305	coproporphyrinogen III oxidase; Provisional; Region: PRK08629
502558000306	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
502558000307	FeS/SAM binding site; other site
502558000308	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
502558000309	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
502558000310	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
502558000311	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
502558000312	Walker A motif; other site
502558000313	ATP binding site [chemical binding]; other site
502558000314	Walker B motif; other site
502558000315	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
502558000316	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
502558000317	Walker A motif; other site
502558000318	ATP binding site [chemical binding]; other site
502558000319	Walker B motif; other site
502558000320	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
502558000321	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
502558000322	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
502558000323	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
502558000324	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
502558000325	Competence protein A; Region: Competence_A; pfam11104
502558000326	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
502558000327	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
502558000328	substrate binding pocket [chemical binding]; other site
502558000329	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
502558000330	membrane-bound complex binding site; other site
502558000331	hinge residues; other site
502558000332	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
502558000333	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
502558000334	substrate binding pocket [chemical binding]; other site
502558000335	membrane-bound complex binding site; other site
502558000336	hinge residues; other site
502558000337	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558000338	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558000339	metal binding site [ion binding]; metal-binding site
502558000340	active site
502558000341	I-site; other site
502558000342	PIN domain; Region: PIN; pfam01850
502558000343	putative active site [active]
502558000344	AIR carboxylase; Region: AIRC; pfam00731
502558000345	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
502558000346	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
502558000347	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
502558000348	dimer interface [polypeptide binding]; other site
502558000349	PYR/PP interface [polypeptide binding]; other site
502558000350	TPP binding site [chemical binding]; other site
502558000351	substrate binding site [chemical binding]; other site
502558000352	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
502558000353	TPP-binding site; other site
502558000354	4Fe-4S binding domain; Region: Fer4; pfam00037
502558000355	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
502558000356	Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543
502558000357	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
502558000358	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
502558000359	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
502558000360	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558000361	acyl-activating enzyme (AAE) consensus motif; other site
502558000362	AMP binding site [chemical binding]; other site
502558000363	active site
502558000364	CoA binding site [chemical binding]; other site
502558000365	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
502558000366	Na binding site [ion binding]; other site
502558000367	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558000368	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558000369	DNA binding residues [nucleotide binding]
502558000370	dimerization interface [polypeptide binding]; other site
502558000371	hypothetical protein; Validated; Region: PRK07121
502558000372	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558000373	Uncharacterized conserved protein [Function unknown]; Region: COG1434
502558000374	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
502558000375	putative active site [active]
502558000376	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
502558000377	Predicted transcriptional regulator [Transcription]; Region: COG1959
502558000378	Transcriptional regulator; Region: Rrf2; pfam02082
502558000379	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
502558000380	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
502558000381	PRC-barrel domain; Region: PRC; pfam05239
502558000382	MgtE intracellular N domain; Region: MgtE_N; smart00924
502558000383	FOG: CBS domain [General function prediction only]; Region: COG0517
502558000384	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
502558000385	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
502558000386	dipeptidase PepV; Reviewed; Region: PRK07318
502558000387	active site
502558000388	metal binding site [ion binding]; metal-binding site
502558000389	TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518
502558000390	Rubrerythrin [Energy production and conversion]; Region: COG1592
502558000391	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
502558000392	binuclear metal center [ion binding]; other site
502558000393	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
502558000394	iron binding site [ion binding]; other site
502558000395	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
502558000396	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
502558000397	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
502558000398	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558000399	active site
502558000400	phosphorylation site [posttranslational modification]
502558000401	intermolecular recognition site; other site
502558000402	dimerization interface [polypeptide binding]; other site
502558000403	LytTr DNA-binding domain; Region: LytTR; smart00850
502558000404	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
502558000405	active site
502558000406	dimer interface [polypeptide binding]; other site
502558000407	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
502558000408	Acylphosphatase; Region: Acylphosphatase; pfam00708
502558000409	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
502558000410	HypF finger; Region: zf-HYPF; pfam07503
502558000411	HypF finger; Region: zf-HYPF; pfam07503
502558000412	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
502558000413	HupF/HypC family; Region: HupF_HypC; pfam01455
502558000414	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
502558000415	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
502558000416	Amidinotransferase; Region: Amidinotransf; cl12043
502558000417	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
502558000418	EamA-like transporter family; Region: EamA; pfam00892
502558000419	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558000420	metabolite-proton symporter; Region: 2A0106; TIGR00883
502558000421	putative substrate translocation pore; other site
502558000422	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558000423	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558000424	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
502558000425	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
502558000426	pyridoxal 5'-phosphate binding site [chemical binding]; other site
502558000427	catalytic residue [active]
502558000428	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
502558000429	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
502558000430	potential catalytic triad [active]
502558000431	conserved cys residue [active]
502558000432	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
502558000433	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
502558000434	Walker A/P-loop; other site
502558000435	ATP binding site [chemical binding]; other site
502558000436	Q-loop/lid; other site
502558000437	ABC transporter signature motif; other site
502558000438	Walker B; other site
502558000439	D-loop; other site
502558000440	H-loop/switch region; other site
502558000441	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558000442	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558000443	acyl carrier protein; Provisional; Region: acpP; PRK00982
502558000444	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
502558000445	30S subunit binding site; other site
502558000446	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
502558000447	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
502558000448	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
502558000449	Substrate binding site; other site
502558000450	Mg++ binding site; other site
502558000451	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
502558000452	active site
502558000453	substrate binding site [chemical binding]; other site
502558000454	CoA binding site [chemical binding]; other site
502558000455	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
502558000456	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
502558000457	4Fe-4S binding domain; Region: Fer4; cl02805
502558000458	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
502558000459	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558000460	molybdopterin cofactor binding site; other site
502558000461	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
502558000462	Response regulator receiver domain; Region: Response_reg; pfam00072
502558000463	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558000464	active site
502558000465	phosphorylation site [posttranslational modification]
502558000466	intermolecular recognition site; other site
502558000467	dimerization interface [polypeptide binding]; other site
502558000468	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
502558000469	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
502558000470	Histidine kinase; Region: His_kinase; pfam06580
502558000471	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558000472	ATP binding site [chemical binding]; other site
502558000473	Mg2+ binding site [ion binding]; other site
502558000474	G-X-G motif; other site
502558000475	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
502558000476	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
502558000477	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
502558000478	active site
502558000479	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
502558000480	putative active site [active]
502558000481	catalytic residue [active]
502558000482	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
502558000483	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558000484	putative substrate translocation pore; other site
502558000485	CAAX protease self-immunity; Region: Abi; pfam02517
502558000486	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
502558000487	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
502558000488	Walker A/P-loop; other site
502558000489	ATP binding site [chemical binding]; other site
502558000490	Q-loop/lid; other site
502558000491	ABC transporter signature motif; other site
502558000492	Walker B; other site
502558000493	D-loop; other site
502558000494	H-loop/switch region; other site
502558000495	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
502558000496	DNA-binding site [nucleotide binding]; DNA binding site
502558000497	Predicted membrane protein [General function prediction only]; Region: COG4194
502558000498	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
502558000499	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
502558000500	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
502558000501	ABC transporter; Region: ABC_tran_2; pfam12848
502558000502	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
502558000503	Cytochrome c552; Region: Cytochrom_C552; pfam02335
502558000504	CcmE; Region: CcmE; cl00994
502558000505	CcmE; Region: CcmE; cl00994
502558000506	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
502558000507	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
502558000508	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
502558000509	Walker A/P-loop; other site
502558000510	ATP binding site [chemical binding]; other site
502558000511	Q-loop/lid; other site
502558000512	ABC transporter signature motif; other site
502558000513	Walker B; other site
502558000514	D-loop; other site
502558000515	H-loop/switch region; other site
502558000516	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386
502558000517	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
502558000518	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
502558000519	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
502558000520	active site
502558000521	tetramer interface; other site
502558000522	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
502558000523	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
502558000524	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
502558000525	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558000526	putative substrate translocation pore; other site
502558000527	Major Facilitator Superfamily; Region: MFS_1; pfam07690
502558000528	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
502558000529	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
502558000530	putative ligand binding site [chemical binding]; other site
502558000531	putative NAD binding site [chemical binding]; other site
502558000532	catalytic site [active]
502558000533	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
502558000534	gating phenylalanine in ion channel; other site
502558000535	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558000536	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558000537	Flavodoxin domain; Region: Flavodoxin_5; cl17428
502558000538	ornithine carbamoyltransferase; Validated; Region: PRK02102
502558000539	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
502558000540	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
502558000541	Major Facilitator Superfamily; Region: MFS_1; pfam07690
502558000542	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558000543	putative substrate translocation pore; other site
502558000544	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
502558000545	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
502558000546	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558000547	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558000548	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558000549	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558000550	sequence-specific DNA binding site [nucleotide binding]; other site
502558000551	salt bridge; other site
502558000552	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
502558000553	FtsX-like permease family; Region: FtsX; pfam02687
502558000554	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
502558000555	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
502558000556	Walker A/P-loop; other site
502558000557	ATP binding site [chemical binding]; other site
502558000558	Q-loop/lid; other site
502558000559	ABC transporter signature motif; other site
502558000560	Walker B; other site
502558000561	D-loop; other site
502558000562	H-loop/switch region; other site
502558000563	HlyD family secretion protein; Region: HlyD_3; pfam13437
502558000564	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
502558000565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558000566	active site
502558000567	phosphorylation site [posttranslational modification]
502558000568	intermolecular recognition site; other site
502558000569	dimerization interface [polypeptide binding]; other site
502558000570	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
502558000571	DNA binding site [nucleotide binding]
502558000572	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
502558000573	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
502558000574	dimer interface [polypeptide binding]; other site
502558000575	phosphorylation site [posttranslational modification]
502558000576	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558000577	ATP binding site [chemical binding]; other site
502558000578	Mg2+ binding site [ion binding]; other site
502558000579	G-X-G motif; other site
502558000580	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
502558000581	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
502558000582	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
502558000583	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558000584	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558000585	DNA binding residues [nucleotide binding]
502558000586	dimerization interface [polypeptide binding]; other site
502558000587	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
502558000588	putative active site [active]
502558000589	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558000590	non-specific DNA binding site [nucleotide binding]; other site
502558000591	salt bridge; other site
502558000592	sequence-specific DNA binding site [nucleotide binding]; other site
502558000593	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558000594	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558000595	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
502558000596	dimerization interface [polypeptide binding]; other site
502558000597	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
502558000598	CoA-transferase family III; Region: CoA_transf_3; pfam02515
502558000599	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
502558000600	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
502558000601	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
502558000602	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
502558000603	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
502558000604	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
502558000605	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
502558000606	active site
502558000607	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
502558000608	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558000609	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558000610	acyl-activating enzyme (AAE) consensus motif; other site
502558000611	acyl-activating enzyme (AAE) consensus motif; other site
502558000612	active site
502558000613	AMP binding site [chemical binding]; other site
502558000614	CoA binding site [chemical binding]; other site
502558000615	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
502558000616	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
502558000617	hypothetical protein; Provisional; Region: PRK05463
502558000618	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
502558000619	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
502558000620	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
502558000621	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
502558000622	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
502558000623	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
502558000624	carboxyltransferase (CT) interaction site; other site
502558000625	biotinylation site [posttranslational modification]; other site
502558000626	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
502558000627	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
502558000628	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
502558000629	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
502558000630	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
502558000631	Ligand Binding Site [chemical binding]; other site
502558000632	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558000633	tricarballylate dehydrogenase; Validated; Region: PRK08274
502558000634	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
502558000635	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558000636	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558000637	DNA binding residues [nucleotide binding]
502558000638	dimerization interface [polypeptide binding]; other site
502558000639	aspartate aminotransferase; Provisional; Region: PRK06836
502558000640	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
502558000641	pyridoxal 5'-phosphate binding site [chemical binding]; other site
502558000642	homodimer interface [polypeptide binding]; other site
502558000643	catalytic residue [active]
502558000644	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
502558000645	Ferritin-like domain; Region: Ferritin; pfam00210
502558000646	ferroxidase diiron center [ion binding]; other site
502558000647	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558000648	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558000649	DNA binding residues [nucleotide binding]
502558000650	dimerization interface [polypeptide binding]; other site
502558000651	hypothetical protein; Validated; Region: PRK07121
502558000652	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558000653	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558000654	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558000655	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
502558000656	dimerization interface [polypeptide binding]; other site
502558000657	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558000658	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
502558000659	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
502558000660	ZIP Zinc transporter; Region: Zip; pfam02535
502558000661	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
502558000662	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
502558000663	dimer interface [polypeptide binding]; other site
502558000664	active site
502558000665	metal binding site [ion binding]; metal-binding site
502558000666	Membrane protein of unknown function; Region: DUF360; pfam04020
502558000667	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
502558000668	Amidinotransferase; Region: Amidinotransf; cl12043
502558000669	23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522
502558000670	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
502558000671	S-adenosylmethionine binding site [chemical binding]; other site
502558000672	D5 N terminal like; Region: D5_N; smart00885
502558000673	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
502558000674	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
502558000675	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558000676	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558000677	non-specific DNA binding site [nucleotide binding]; other site
502558000678	salt bridge; other site
502558000679	sequence-specific DNA binding site [nucleotide binding]; other site
502558000680	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
502558000681	non-specific DNA binding site [nucleotide binding]; other site
502558000682	salt bridge; other site
502558000683	sequence-specific DNA binding site [nucleotide binding]; other site
502558000684	multiple promoter invertase; Provisional; Region: mpi; PRK13413
502558000685	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
502558000686	catalytic residues [active]
502558000687	catalytic nucleophile [active]
502558000688	Recombinase; Region: Recombinase; pfam07508
502558000689	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
502558000690	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
502558000691	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558000692	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558000693	metal binding site [ion binding]; metal-binding site
502558000694	active site
502558000695	I-site; other site
502558000696	PAS fold; Region: PAS_3; pfam08447
502558000697	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558000698	metal binding site [ion binding]; metal-binding site
502558000699	active site
502558000700	I-site; other site
502558000701	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
502558000702	Maf-like protein; Region: Maf; pfam02545
502558000703	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
502558000704	active site
502558000705	dimer interface [polypeptide binding]; other site
502558000706	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
502558000707	active site
502558000708	FtsH Extracellular; Region: FtsH_ext; pfam06480
502558000709	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
502558000710	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558000711	Walker A motif; other site
502558000712	ATP binding site [chemical binding]; other site
502558000713	Walker B motif; other site
502558000714	arginine finger; other site
502558000715	Peptidase family M41; Region: Peptidase_M41; pfam01434
502558000716	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
502558000717	dihydropteroate synthase; Region: DHPS; TIGR01496
502558000718	substrate binding pocket [chemical binding]; other site
502558000719	dimer interface [polypeptide binding]; other site
502558000720	inhibitor binding site; inhibition site
502558000721	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
502558000722	catalytic center binding site [active]
502558000723	ATP binding site [chemical binding]; other site
502558000724	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
502558000725	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
502558000726	FAD binding domain; Region: FAD_binding_2; pfam00890
502558000727	hypothetical protein; Validated; Region: PRK07121
502558000728	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558000729	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558000730	DNA binding residues [nucleotide binding]
502558000731	dimerization interface [polypeptide binding]; other site
502558000732	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
502558000733	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
502558000734	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
502558000735	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558000736	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
502558000737	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558000738	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558000739	DNA binding residues [nucleotide binding]
502558000740	dimerization interface [polypeptide binding]; other site
502558000741	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
502558000742	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
502558000743	dimer interface [polypeptide binding]; other site
502558000744	active site
502558000745	CoA binding pocket [chemical binding]; other site
502558000746	VanW like protein; Region: VanW; pfam04294
502558000747	conserved repeat domain; Region: B_ant_repeat; TIGR01451
502558000748	Domain of unknown function DUF11; Region: DUF11; pfam01345
502558000749	Domain of unknown function DUF11; Region: DUF11; pfam01345
502558000750	Domain of unknown function DUF11; Region: DUF11; pfam01345
502558000751	S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361
502558000752	conserved repeat domain; Region: B_ant_repeat; TIGR01451
502558000753	conserved repeat domain; Region: B_ant_repeat; TIGR01451
502558000754	Domain of unknown function DUF11; Region: DUF11; pfam01345
502558000755	conserved repeat domain; Region: B_ant_repeat; TIGR01451
502558000756	Domain of unknown function DUF11; Region: DUF11; pfam01345
502558000757	conserved repeat domain; Region: B_ant_repeat; TIGR01451
502558000758	conserved repeat domain; Region: B_ant_repeat; TIGR01451
502558000759	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
502558000760	Domain of unknown function DUF11; Region: DUF11; cl17728
502558000761	conserved repeat domain; Region: B_ant_repeat; TIGR01451
502558000762	Domain of unknown function DUF11; Region: DUF11; pfam01345
502558000763	conserved repeat domain; Region: B_ant_repeat; TIGR01451
502558000764	Domain of unknown function DUF11; Region: DUF11; pfam01345
502558000765	Domain of unknown function DUF11; Region: DUF11; pfam01345
502558000766	Domain of unknown function DUF11; Region: DUF11; pfam01345
502558000767	Domain of unknown function DUF11; Region: DUF11; cl17728
502558000768	C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD); Region: AP_MHD_Cterm; cl10970
502558000769	Domain of unknown function DUF11; Region: DUF11; pfam01345
502558000770	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
502558000771	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
502558000772	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
502558000773	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
502558000774	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
502558000775	CoA-transferase family III; Region: CoA_transf_3; pfam02515
502558000776	Major Facilitator Superfamily; Region: MFS_1; pfam07690
502558000777	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558000778	putative substrate translocation pore; other site
502558000779	chaperone protein DnaK; Region: prok_dnaK; TIGR02350
502558000780	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
502558000781	CoA-transferase family III; Region: CoA_transf_3; pfam02515
502558000782	Major Facilitator Superfamily; Region: MFS_1; pfam07690
502558000783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558000784	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
502558000785	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
502558000786	active site
502558000787	FMN binding site [chemical binding]; other site
502558000788	substrate binding site [chemical binding]; other site
502558000789	putative catalytic residue [active]
502558000790	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
502558000791	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
502558000792	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
502558000793	substrate binding site [chemical binding]; other site
502558000794	oxyanion hole (OAH) forming residues; other site
502558000795	trimer interface [polypeptide binding]; other site
502558000796	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
502558000797	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558000798	acyl-activating enzyme (AAE) consensus motif; other site
502558000799	AMP binding site [chemical binding]; other site
502558000800	active site
502558000801	CoA binding site [chemical binding]; other site
502558000802	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
502558000803	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
502558000804	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
502558000805	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
502558000806	active site
502558000807	TIGR03084 family protein; Region: TIGR03084
502558000808	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
502558000809	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
502558000810	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
502558000811	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
502558000812	Coenzyme A binding pocket [chemical binding]; other site
502558000813	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
502558000814	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
502558000815	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
502558000816	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
502558000817	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
502558000818	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558000819	Walker A motif; other site
502558000820	ATP binding site [chemical binding]; other site
502558000821	Walker B motif; other site
502558000822	arginine finger; other site
502558000823	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
502558000824	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
502558000825	dimer interface [polypeptide binding]; other site
502558000826	phosphorylation site [posttranslational modification]
502558000827	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558000828	ATP binding site [chemical binding]; other site
502558000829	Mg2+ binding site [ion binding]; other site
502558000830	G-X-G motif; other site
502558000831	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
502558000832	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558000833	active site
502558000834	phosphorylation site [posttranslational modification]
502558000835	intermolecular recognition site; other site
502558000836	dimerization interface [polypeptide binding]; other site
502558000837	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
502558000838	DNA binding site [nucleotide binding]
502558000839	pantothenate kinase; Reviewed; Region: PRK13318
502558000840	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558000841	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558000842	DNA binding residues [nucleotide binding]
502558000843	dimerization interface [polypeptide binding]; other site
502558000844	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
502558000845	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558000846	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558000847	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
502558000848	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
502558000849	Potassium binding sites [ion binding]; other site
502558000850	Cesium cation binding sites [ion binding]; other site
502558000851	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
502558000852	active site
502558000853	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
502558000854	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558000855	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558000856	DNA binding residues [nucleotide binding]
502558000857	dimerization interface [polypeptide binding]; other site
502558000858	hypothetical protein; Validated; Region: PRK07121
502558000859	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558000860	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558000861	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
502558000862	Na2 binding site [ion binding]; other site
502558000863	putative substrate binding site 1 [chemical binding]; other site
502558000864	Na binding site 1 [ion binding]; other site
502558000865	putative substrate binding site 2 [chemical binding]; other site
502558000866	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558000867	metal binding site [ion binding]; metal-binding site
502558000868	active site
502558000869	I-site; other site
502558000870	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
502558000871	PAS domain; Region: PAS_9; pfam13426
502558000872	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
502558000873	putative active site [active]
502558000874	heme pocket [chemical binding]; other site
502558000875	PAS domain; Region: PAS_9; pfam13426
502558000876	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
502558000877	putative active site [active]
502558000878	heme pocket [chemical binding]; other site
502558000879	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
502558000880	PAS fold; Region: PAS_3; pfam08447
502558000881	putative active site [active]
502558000882	heme pocket [chemical binding]; other site
502558000883	heat shock protein 90; Provisional; Region: PRK05218
502558000884	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558000885	ATP binding site [chemical binding]; other site
502558000886	Mg2+ binding site [ion binding]; other site
502558000887	G-X-G motif; other site
502558000888	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
502558000889	dimer interface [polypeptide binding]; other site
502558000890	FMN binding site [chemical binding]; other site
502558000891	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558000892	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558000893	LysR substrate binding domain; Region: LysR_substrate; pfam03466
502558000894	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558000895	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558000896	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
502558000897	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
502558000898	amphipathic channel; other site
502558000899	Asn-Pro-Ala signature motifs; other site
502558000900	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
502558000901	Ligand Binding Site [chemical binding]; other site
502558000902	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
502558000903	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
502558000904	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
502558000905	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
502558000906	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
502558000907	active site residue [active]
502558000908	Major Facilitator Superfamily; Region: MFS_1; pfam07690
502558000909	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558000910	putative substrate translocation pore; other site
502558000911	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558000912	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
502558000913	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
502558000914	Isochorismatase family; Region: Isochorismatase; pfam00857
502558000915	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
502558000916	catalytic triad [active]
502558000917	conserved cis-peptide bond; other site
502558000918	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
502558000919	diiron binding motif [ion binding]; other site
502558000920	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
502558000921	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
502558000922	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
502558000923	homodimer interface [polypeptide binding]; other site
502558000924	metal binding site [ion binding]; metal-binding site
502558000925	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
502558000926	homodimer interface [polypeptide binding]; other site
502558000927	active site
502558000928	putative chemical substrate binding site [chemical binding]; other site
502558000929	metal binding site [ion binding]; metal-binding site
502558000930	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558000931	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558000932	active site
502558000933	I-site; other site
502558000934	metal binding site [ion binding]; metal-binding site
502558000935	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
502558000936	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
502558000937	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
502558000938	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
502558000939	putative active site [active]
502558000940	heme pocket [chemical binding]; other site
502558000941	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
502558000942	putative active site [active]
502558000943	heme pocket [chemical binding]; other site
502558000944	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
502558000945	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558000946	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558000947	metal binding site [ion binding]; metal-binding site
502558000948	active site
502558000949	I-site; other site
502558000950	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
502558000951	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
502558000952	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
502558000953	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
502558000954	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
502558000955	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
502558000956	Yqey-like protein; Region: YqeY; pfam09424
502558000957	Uncharacterized conserved protein [Function unknown]; Region: COG3402
502558000958	Bacterial PH domain; Region: DUF304; pfam03703
502558000959	Predicted membrane protein [Function unknown]; Region: COG3428
502558000960	Bacterial PH domain; Region: DUF304; pfam03703
502558000961	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
502558000962	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
502558000963	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
502558000964	Domain of unknown function DUF21; Region: DUF21; pfam01595
502558000965	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
502558000966	Transporter associated domain; Region: CorC_HlyC; smart01091
502558000967	PspC domain; Region: PspC; pfam04024
502558000968	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
502558000969	TrkA-N domain; Region: TrkA_N; pfam02254
502558000970	TrkA-C domain; Region: TrkA_C; pfam02080
502558000971	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
502558000972	TrkA-N domain; Region: TrkA_N; pfam02254
502558000973	TrkA-C domain; Region: TrkA_C; pfam02080
502558000974	adenylosuccinate lyase; Provisional; Region: PRK07492
502558000975	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
502558000976	tetramer interface [polypeptide binding]; other site
502558000977	active site
502558000978	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
502558000979	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
502558000980	4Fe-4S binding domain; Region: Fer4_5; pfam12801
502558000981	4Fe-4S binding domain; Region: Fer4_5; pfam12801
502558000982	4Fe-4S binding domain; Region: Fer4; pfam00037
502558000983	NapD protein; Region: NapD; pfam03927
502558000984	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
502558000985	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
502558000986	[4Fe-4S] binding site [ion binding]; other site
502558000987	molybdopterin cofactor binding site; other site
502558000988	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
502558000989	molybdopterin cofactor binding site; other site
502558000990	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
502558000991	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
502558000992	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
502558000993	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
502558000994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558000995	active site
502558000996	phosphorylation site [posttranslational modification]
502558000997	intermolecular recognition site; other site
502558000998	dimerization interface [polypeptide binding]; other site
502558000999	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
502558001000	DNA binding site [nucleotide binding]
502558001001	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
502558001002	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
502558001003	dimerization interface [polypeptide binding]; other site
502558001004	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
502558001005	dimer interface [polypeptide binding]; other site
502558001006	phosphorylation site [posttranslational modification]
502558001007	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558001008	ATP binding site [chemical binding]; other site
502558001009	Mg2+ binding site [ion binding]; other site
502558001010	G-X-G motif; other site
502558001011	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
502558001012	active site
502558001013	ATP binding site [chemical binding]; other site
502558001014	substrate binding site [chemical binding]; other site
502558001015	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
502558001016	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
502558001017	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
502558001018	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
502558001019	dimerization interface [polypeptide binding]; other site
502558001020	ATP binding site [chemical binding]; other site
502558001021	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
502558001022	dimerization interface [polypeptide binding]; other site
502558001023	ATP binding site [chemical binding]; other site
502558001024	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
502558001025	putative active site [active]
502558001026	catalytic triad [active]
502558001027	Erythromycin esterase; Region: Erythro_esteras; cl17110
502558001028	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381
502558001029	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
502558001030	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
502558001031	Isochorismatase family; Region: Isochorismatase; pfam00857
502558001032	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
502558001033	catalytic triad [active]
502558001034	conserved cis-peptide bond; other site
502558001035	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
502558001036	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558001037	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558001038	DNA binding residues [nucleotide binding]
502558001039	dimerization interface [polypeptide binding]; other site
502558001040	hypothetical protein; Validated; Region: PRK07121
502558001041	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
502558001042	putative oxygen-independent coproporphyrinogen III oxidase; Region: hemN_rel; TIGR00539
502558001043	Asp23 family; Region: Asp23; pfam03780
502558001044	Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031
502558001045	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
502558001046	glutamate synthase (NADPH), homotetrameric; Region: gltA; TIGR01316
502558001047	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
502558001048	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
502558001049	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
502558001050	catalytic loop [active]
502558001051	iron binding site [ion binding]; other site
502558001052	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
502558001053	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
502558001054	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
502558001055	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
502558001056	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
502558001057	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
502558001058	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
502558001059	ABC-ATPase subunit interface; other site
502558001060	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558001061	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
502558001062	Walker A/P-loop; other site
502558001063	ATP binding site [chemical binding]; other site
502558001064	Q-loop/lid; other site
502558001065	ABC transporter signature motif; other site
502558001066	Walker B; other site
502558001067	D-loop; other site
502558001068	H-loop/switch region; other site
502558001069	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
502558001070	classical (c) SDRs; Region: SDR_c; cd05233
502558001071	NAD(P) binding site [chemical binding]; other site
502558001072	active site
502558001073	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558001074	DNA binding residues [nucleotide binding]
502558001075	dimerization interface [polypeptide binding]; other site
502558001076	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
502558001077	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
502558001078	aconitate hydratase; Validated; Region: PRK09277
502558001079	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
502558001080	substrate binding site [chemical binding]; other site
502558001081	ligand binding site [chemical binding]; other site
502558001082	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
502558001083	substrate binding site [chemical binding]; other site
502558001084	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
502558001085	23S rRNA interface [nucleotide binding]; other site
502558001086	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
502558001087	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
502558001088	peripheral dimer interface [polypeptide binding]; other site
502558001089	core dimer interface [polypeptide binding]; other site
502558001090	L10 interface [polypeptide binding]; other site
502558001091	L11 interface [polypeptide binding]; other site
502558001092	putative EF-Tu interaction site [polypeptide binding]; other site
502558001093	putative EF-G interaction site [polypeptide binding]; other site
502558001094	Protein of unknown function (DUF4013); Region: DUF4013; pfam13197
502558001095	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
502558001096	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
502558001097	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
502558001098	dimer interface [polypeptide binding]; other site
502558001099	pyridoxal 5'-phosphate binding site [chemical binding]; other site
502558001100	catalytic residue [active]
502558001101	phytoene desaturase; Region: crtI_fam; TIGR02734
502558001102	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
502558001103	hydroxyglutarate oxidase; Provisional; Region: PRK11728
502558001104	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
502558001105	active site lid residues [active]
502558001106	substrate binding pocket [chemical binding]; other site
502558001107	catalytic residues [active]
502558001108	substrate-Mg2+ binding site; other site
502558001109	aspartate-rich region 1; other site
502558001110	aspartate-rich region 2; other site
502558001111	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
502558001112	Integral membrane protein DUF92; Region: DUF92; pfam01940
502558001113	HipA N-terminal domain; Region: Couple_hipA; pfam13657
502558001114	HipA-like N-terminal domain; Region: HipA_N; pfam07805
502558001115	HipA-like C-terminal domain; Region: HipA_C; pfam07804
502558001116	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558001117	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558001118	non-specific DNA binding site [nucleotide binding]; other site
502558001119	salt bridge; other site
502558001120	sequence-specific DNA binding site [nucleotide binding]; other site
502558001121	transcriptional regulator MalT; Provisional; Region: PRK04841
502558001122	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
502558001123	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
502558001124	putative ATP binding site [chemical binding]; other site
502558001125	putative substrate interface [chemical binding]; other site
502558001126	TatD related DNase; Region: TatD_DNase; pfam01026
502558001127	active site
502558001128	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558001129	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558001130	non-specific DNA binding site [nucleotide binding]; other site
502558001131	salt bridge; other site
502558001132	sequence-specific DNA binding site [nucleotide binding]; other site
502558001133	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
502558001134	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
502558001135	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
502558001136	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
502558001137	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
502558001138	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
502558001139	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
502558001140	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558001141	active site
502558001142	phosphorylation site [posttranslational modification]
502558001143	intermolecular recognition site; other site
502558001144	dimerization interface [polypeptide binding]; other site
502558001145	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
502558001146	DNA binding site [nucleotide binding]
502558001147	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
502558001148	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558001149	Walker A/P-loop; other site
502558001150	ATP binding site [chemical binding]; other site
502558001151	Q-loop/lid; other site
502558001152	ABC transporter signature motif; other site
502558001153	Walker B; other site
502558001154	D-loop; other site
502558001155	H-loop/switch region; other site
502558001156	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
502558001157	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
502558001158	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
502558001159	phosphorylation site [posttranslational modification]
502558001160	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
502558001161	ATP binding site [chemical binding]; other site
502558001162	Mg2+ binding site [ion binding]; other site
502558001163	G-X-G motif; other site
502558001164	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
502558001165	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
502558001166	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558001167	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558001168	H+ Antiporter protein; Region: 2A0121; TIGR00900
502558001169	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558001170	putative substrate translocation pore; other site
502558001171	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558001172	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558001173	DNA binding residues [nucleotide binding]
502558001174	hypothetical protein; Validated; Region: PRK07121
502558001175	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558001176	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
502558001177	active site
502558001178	ADP/pyrophosphate binding site [chemical binding]; other site
502558001179	allosteric effector site; other site
502558001180	dimerization interface [polypeptide binding]; other site
502558001181	fructose-1,6-bisphosphate binding site; other site
502558001182	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
502558001183	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
502558001184	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
502558001185	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
502558001186	FeS/SAM binding site; other site
502558001187	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
502558001188	ATP cone domain; Region: ATP-cone; pfam03477
502558001189	Class III ribonucleotide reductase; Region: RNR_III; cd01675
502558001190	effector binding site; other site
502558001191	active site
502558001192	Zn binding site [ion binding]; other site
502558001193	glycine loop; other site
502558001194	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
502558001195	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558001196	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558001197	DNA binding residues [nucleotide binding]
502558001198	dimerization interface [polypeptide binding]; other site
502558001199	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558001200	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558001201	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558001202	recombination factor protein RarA; Reviewed; Region: PRK13342
502558001203	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558001204	Walker A motif; other site
502558001205	ATP binding site [chemical binding]; other site
502558001206	Walker B motif; other site
502558001207	arginine finger; other site
502558001208	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
502558001209	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
502558001210	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
502558001211	Domain of unknown function DUF20; Region: UPF0118; pfam01594
502558001212	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
502558001213	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
502558001214	motif 1; other site
502558001215	active site
502558001216	motif 2; other site
502558001217	motif 3; other site
502558001218	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
502558001219	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
502558001220	YceG-like family; Region: YceG; pfam02618
502558001221	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
502558001222	dimerization interface [polypeptide binding]; other site
502558001223	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
502558001224	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
502558001225	active site
502558001226	motif I; other site
502558001227	motif II; other site
502558001228	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
502558001229	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
502558001230	Tetramer interface [polypeptide binding]; other site
502558001231	active site
502558001232	FMN-binding site [chemical binding]; other site
502558001233	shikimate kinase; Reviewed; Region: aroK; PRK00131
502558001234	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
502558001235	ADP binding site [chemical binding]; other site
502558001236	magnesium binding site [ion binding]; other site
502558001237	putative shikimate binding site; other site
502558001238	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
502558001239	active site
502558001240	dimer interface [polypeptide binding]; other site
502558001241	metal binding site [ion binding]; metal-binding site
502558001242	Dehydroquinase class II; Region: DHquinase_II; pfam01220
502558001243	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
502558001244	active site
502558001245	trimer interface [polypeptide binding]; other site
502558001246	dimer interface [polypeptide binding]; other site
502558001247	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
502558001248	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
502558001249	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
502558001250	active site
502558001251	elongation factor P; Validated; Region: PRK00529
502558001252	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
502558001253	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
502558001254	RNA binding site [nucleotide binding]; other site
502558001255	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
502558001256	RNA binding site [nucleotide binding]; other site
502558001257	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
502558001258	P2 response regulator binding domain; Region: P2; pfam07194
502558001259	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558001260	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558001261	metal binding site [ion binding]; metal-binding site
502558001262	active site
502558001263	I-site; other site
502558001264	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
502558001265	dimerization interface [polypeptide binding]; other site
502558001266	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
502558001267	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
502558001268	dimer interface [polypeptide binding]; other site
502558001269	putative CheW interface [polypeptide binding]; other site
502558001270	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
502558001271	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
502558001272	putative DNA binding site [nucleotide binding]; other site
502558001273	putative Zn2+ binding site [ion binding]; other site
502558001274	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
502558001275	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
502558001276	Methyltransferase domain; Region: Methyltransf_31; pfam13847
502558001277	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
502558001278	S-adenosylmethionine binding site [chemical binding]; other site
502558001279	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558001280	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558001281	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558001282	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558001283	non-specific DNA binding site [nucleotide binding]; other site
502558001284	salt bridge; other site
502558001285	sequence-specific DNA binding site [nucleotide binding]; other site
502558001286	integrase; Provisional; Region: int; PHA02601
502558001287	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
502558001288	Int/Topo IB signature motif; other site
502558001289	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
502558001290	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
502558001291	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
502558001292	P-loop; other site
502558001293	Magnesium ion binding site [ion binding]; other site
502558001294	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
502558001295	ParB-like nuclease domain; Region: ParBc; pfam02195
502558001296	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
502558001297	Abi-like protein; Region: Abi_2; pfam07751
502558001298	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
502558001299	active site
502558001300	catalytic site [active]
502558001301	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
502558001302	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
502558001303	NlpC/P60 family; Region: NLPC_P60; pfam00877
502558001304	AAA-like domain; Region: AAA_10; pfam12846
502558001305	Domain of unknown function DUF87; Region: DUF87; pfam01935
502558001306	PrgI family protein; Region: PrgI; pfam12666
502558001307	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
502558001308	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
502558001309	Walker A motif; other site
502558001310	ATP binding site [chemical binding]; other site
502558001311	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
502558001312	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
502558001313	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558001314	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
502558001315	Walker A motif; other site
502558001316	ATP binding site [chemical binding]; other site
502558001317	Walker B motif; other site
502558001318	arginine finger; other site
502558001319	Helix-turn-helix domain; Region: HTH_36; pfam13730
502558001320	Helix-turn-helix domain; Region: HTH_17; cl17695
502558001321	Helix-turn-helix domain; Region: HTH_17; pfam12728
502558001322	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
502558001323	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
502558001324	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
502558001325	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
502558001326	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
502558001327	Walker A/P-loop; other site
502558001328	ATP binding site [chemical binding]; other site
502558001329	Q-loop/lid; other site
502558001330	ABC transporter signature motif; other site
502558001331	Walker B; other site
502558001332	D-loop; other site
502558001333	H-loop/switch region; other site
502558001334	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
502558001335	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558001336	Walker A/P-loop; other site
502558001337	ATP binding site [chemical binding]; other site
502558001338	Q-loop/lid; other site
502558001339	ABC transporter signature motif; other site
502558001340	Walker B; other site
502558001341	D-loop; other site
502558001342	H-loop/switch region; other site
502558001343	Cobalt transport protein; Region: CbiQ; cl00463
502558001344	conserved hypothetical integral membrane protein TIGR02185; Region: Trep_Strep
502558001345	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
502558001346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558001347	Walker A/P-loop; other site
502558001348	ATP binding site [chemical binding]; other site
502558001349	Q-loop/lid; other site
502558001350	ABC transporter signature motif; other site
502558001351	Walker B; other site
502558001352	D-loop; other site
502558001353	H-loop/switch region; other site
502558001354	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
502558001355	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
502558001356	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558001357	Walker A/P-loop; other site
502558001358	ATP binding site [chemical binding]; other site
502558001359	Q-loop/lid; other site
502558001360	ABC transporter signature motif; other site
502558001361	Walker B; other site
502558001362	D-loop; other site
502558001363	H-loop/switch region; other site
502558001364	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558001365	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558001366	Helix-turn-helix domain; Region: HTH_17; pfam12728
502558001367	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
502558001368	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
502558001369	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
502558001370	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
502558001371	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558001372	Walker A/P-loop; other site
502558001373	ATP binding site [chemical binding]; other site
502558001374	Q-loop/lid; other site
502558001375	ABC transporter signature motif; other site
502558001376	Walker B; other site
502558001377	D-loop; other site
502558001378	H-loop/switch region; other site
502558001379	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
502558001380	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
502558001381	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558001382	Walker A/P-loop; other site
502558001383	ATP binding site [chemical binding]; other site
502558001384	Q-loop/lid; other site
502558001385	ABC transporter signature motif; other site
502558001386	Walker B; other site
502558001387	D-loop; other site
502558001388	H-loop/switch region; other site
502558001389	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
502558001390	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
502558001391	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
502558001392	Walker A/P-loop; other site
502558001393	ATP binding site [chemical binding]; other site
502558001394	Q-loop/lid; other site
502558001395	ABC transporter signature motif; other site
502558001396	Walker B; other site
502558001397	D-loop; other site
502558001398	H-loop/switch region; other site
502558001399	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558001400	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
502558001401	Walker A/P-loop; other site
502558001402	ATP binding site [chemical binding]; other site
502558001403	Q-loop/lid; other site
502558001404	ABC transporter signature motif; other site
502558001405	Walker B; other site
502558001406	D-loop; other site
502558001407	H-loop/switch region; other site
502558001408	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
502558001409	Helix-turn-helix domain; Region: HTH_18; pfam12833
502558001410	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
502558001411	Predicted methyltransferases [General function prediction only]; Region: COG0313
502558001412	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
502558001413	putative SAM binding site [chemical binding]; other site
502558001414	putative homodimer interface [polypeptide binding]; other site
502558001415	Protein of unknown function DUF45; Region: DUF45; pfam01863
502558001416	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
502558001417	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
502558001418	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
502558001419	active site
502558001420	HIGH motif; other site
502558001421	KMSKS motif; other site
502558001422	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
502558001423	tRNA binding surface [nucleotide binding]; other site
502558001424	anticodon binding site; other site
502558001425	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
502558001426	dimer interface [polypeptide binding]; other site
502558001427	phosphorylation site [posttranslational modification]
502558001428	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558001429	ATP binding site [chemical binding]; other site
502558001430	Mg2+ binding site [ion binding]; other site
502558001431	G-X-G motif; other site
502558001432	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
502558001433	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558001434	active site
502558001435	phosphorylation site [posttranslational modification]
502558001436	intermolecular recognition site; other site
502558001437	dimerization interface [polypeptide binding]; other site
502558001438	MoxR-like ATPases [General function prediction only]; Region: COG0714
502558001439	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558001440	Walker A motif; other site
502558001441	ATP binding site [chemical binding]; other site
502558001442	Walker B motif; other site
502558001443	arginine finger; other site
502558001444	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
502558001445	Protein of unknown function DUF58; Region: DUF58; pfam01882
502558001446	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
502558001447	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
502558001448	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
502558001449	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
502558001450	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558001451	Response regulator receiver domain; Region: Response_reg; pfam00072
502558001452	active site
502558001453	phosphorylation site [posttranslational modification]
502558001454	intermolecular recognition site; other site
502558001455	dimerization interface [polypeptide binding]; other site
502558001456	PAS domain S-box; Region: sensory_box; TIGR00229
502558001457	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
502558001458	putative active site [active]
502558001459	heme pocket [chemical binding]; other site
502558001460	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558001461	metal binding site [ion binding]; metal-binding site
502558001462	active site
502558001463	I-site; other site
502558001464	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
502558001465	Hpt domain; Region: Hpt; pfam01627
502558001466	putative binding surface; other site
502558001467	active site
502558001468	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
502558001469	active site
502558001470	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
502558001471	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
502558001472	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
502558001473	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
502558001474	S-adenosylmethionine binding site [chemical binding]; other site
502558001475	Divergent AAA domain; Region: AAA_4; pfam04326
502558001476	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
502558001477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
502558001478	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
502558001479	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
502558001480	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
502558001481	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
502558001482	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
502558001483	motif II; other site
502558001484	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
502558001485	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
502558001486	NAD binding site [chemical binding]; other site
502558001487	dimer interface [polypeptide binding]; other site
502558001488	substrate binding site [chemical binding]; other site
502558001489	tetramer (dimer of dimers) interface [polypeptide binding]; other site
502558001490	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
502558001491	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
502558001492	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
502558001493	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
502558001494	catalytic loop [active]
502558001495	iron binding site [ion binding]; other site
502558001496	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
502558001497	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558001498	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558001499	molybdopterin cofactor binding site; other site
502558001500	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
502558001501	molybdopterin cofactor binding site; other site
502558001502	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
502558001503	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
502558001504	amidophosphoribosyltransferase; Provisional; Region: PRK05793
502558001505	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
502558001506	active site
502558001507	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
502558001508	active site
502558001509	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
502558001510	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
502558001511	Predicted transcriptional regulator [Transcription]; Region: COG2378
502558001512	WYL domain; Region: WYL; pfam13280
502558001513	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
502558001514	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
502558001515	HIRAN domain; Region: HIRAN; pfam08797
502558001516	proteobacterial sortase system OmpA family protein; Region: pdsO; TIGR03789
502558001517	Fic/DOC family; Region: Fic; pfam02661
502558001518	Major Facilitator Superfamily; Region: MFS_1; pfam07690
502558001519	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558001520	putative substrate translocation pore; other site
502558001521	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558001522	FOG: CBS domain [General function prediction only]; Region: COG0517
502558001523	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
502558001524	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234
502558001525	active site
502558001526	catalytic residues [active]
502558001527	metal binding site [ion binding]; metal-binding site
502558001528	aspartate kinase; Reviewed; Region: PRK06635
502558001529	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
502558001530	putative nucleotide binding site [chemical binding]; other site
502558001531	putative catalytic residues [active]
502558001532	putative Mg ion binding site [ion binding]; other site
502558001533	putative aspartate binding site [chemical binding]; other site
502558001534	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
502558001535	putative allosteric regulatory site; other site
502558001536	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
502558001537	putative allosteric regulatory residue; other site
502558001538	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
502558001539	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
502558001540	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
502558001541	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
502558001542	RNA binding surface [nucleotide binding]; other site
502558001543	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
502558001544	S-adenosylmethionine binding site [chemical binding]; other site
502558001545	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
502558001546	YwpF-like protein; Region: YwpF; pfam14183
502558001547	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
502558001548	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
502558001549	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
502558001550	putative active site [active]
502558001551	putative metal binding site [ion binding]; other site
502558001552	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558001553	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558001554	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
502558001555	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
502558001556	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
502558001557	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
502558001558	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
502558001559	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
502558001560	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
502558001561	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
502558001562	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558001563	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558001564	DNA binding residues [nucleotide binding]
502558001565	dimerization interface [polypeptide binding]; other site
502558001566	hypothetical protein; Validated; Region: PRK07121
502558001567	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558001568	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558001569	DNA binding residues [nucleotide binding]
502558001570	dimerization interface [polypeptide binding]; other site
502558001571	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558001572	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558001573	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558001574	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558001575	non-specific DNA binding site [nucleotide binding]; other site
502558001576	salt bridge; other site
502558001577	sequence-specific DNA binding site [nucleotide binding]; other site
502558001578	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
502558001579	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
502558001580	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
502558001581	hypothetical protein; Validated; Region: PRK07121
502558001582	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558001583	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558001584	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558001585	DNA binding residues [nucleotide binding]
502558001586	dimerization interface [polypeptide binding]; other site
502558001587	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
502558001588	CoenzymeA binding site [chemical binding]; other site
502558001589	subunit interaction site [polypeptide binding]; other site
502558001590	PHB binding site; other site
502558001591	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
502558001592	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558001593	molybdopterin cofactor binding site; other site
502558001594	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
502558001595	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
502558001596	4Fe-4S binding domain; Region: Fer4; cl02805
502558001597	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
502558001598	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
502558001599	Predicted transcriptional regulators [Transcription]; Region: COG1725
502558001600	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
502558001601	DNA-binding site [nucleotide binding]; DNA binding site
502558001602	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
502558001603	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
502558001604	pyruvate carboxylase subunit B; Validated; Region: PRK09282
502558001605	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
502558001606	active site
502558001607	catalytic residues [active]
502558001608	metal binding site [ion binding]; metal-binding site
502558001609	homodimer binding site [polypeptide binding]; other site
502558001610	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
502558001611	carboxyltransferase (CT) interaction site; other site
502558001612	biotinylation site [posttranslational modification]; other site
502558001613	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
502558001614	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
502558001615	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
502558001616	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
502558001617	Asp23 family; Region: Asp23; pfam03780
502558001618	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
502558001619	putative RNA binding site [nucleotide binding]; other site
502558001620	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
502558001621	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
502558001622	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
502558001623	TPP-binding site; other site
502558001624	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
502558001625	PYR/PP interface [polypeptide binding]; other site
502558001626	dimer interface [polypeptide binding]; other site
502558001627	TPP binding site [chemical binding]; other site
502558001628	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
502558001629	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
502558001630	Coenzyme A binding pocket [chemical binding]; other site
502558001631	ferric uptake regulator; Provisional; Region: fur; PRK09462
502558001632	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
502558001633	metal binding site 2 [ion binding]; metal-binding site
502558001634	putative DNA binding helix; other site
502558001635	metal binding site 1 [ion binding]; metal-binding site
502558001636	dimer interface [polypeptide binding]; other site
502558001637	structural Zn2+ binding site [ion binding]; other site
502558001638	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
502558001639	RNA binding site [nucleotide binding]; other site
502558001640	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
502558001641	RNA binding site [nucleotide binding]; other site
502558001642	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
502558001643	RNA binding site [nucleotide binding]; other site
502558001644	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
502558001645	RNA binding site [nucleotide binding]; other site
502558001646	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
502558001647	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
502558001648	catalytic triad [active]
502558001649	catalytic triad [active]
502558001650	oxyanion hole [active]
502558001651	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
502558001652	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
502558001653	Ligand Binding Site [chemical binding]; other site
502558001654	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
502558001655	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
502558001656	ATP-binding [chemical binding]; other site
502558001657	CoA-binding site [chemical binding]; other site
502558001658	Predicted membrane protein [Function unknown]; Region: COG2855
502558001659	excinuclease ABC subunit B; Provisional; Region: PRK05298
502558001660	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
502558001661	ATP binding site [chemical binding]; other site
502558001662	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
502558001663	nucleotide binding region [chemical binding]; other site
502558001664	ATP-binding site [chemical binding]; other site
502558001665	Ultra-violet resistance protein B; Region: UvrB; pfam12344
502558001666	UvrB/uvrC motif; Region: UVR; pfam02151
502558001667	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
502558001668	AAA domain; Region: AAA_14; pfam13173
502558001669	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
502558001670	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
502558001671	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
502558001672	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
502558001673	Walker A/P-loop; other site
502558001674	ATP binding site [chemical binding]; other site
502558001675	Q-loop/lid; other site
502558001676	ABC transporter signature motif; other site
502558001677	Walker B; other site
502558001678	D-loop; other site
502558001679	H-loop/switch region; other site
502558001680	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558001681	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558001682	non-specific DNA binding site [nucleotide binding]; other site
502558001683	salt bridge; other site
502558001684	sequence-specific DNA binding site [nucleotide binding]; other site
502558001685	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
502558001686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558001687	active site
502558001688	phosphorylation site [posttranslational modification]
502558001689	intermolecular recognition site; other site
502558001690	dimerization interface [polypeptide binding]; other site
502558001691	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
502558001692	DNA binding site [nucleotide binding]
502558001693	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
502558001694	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
502558001695	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
502558001696	Ligand Binding Site [chemical binding]; other site
502558001697	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
502558001698	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
502558001699	dimer interface [polypeptide binding]; other site
502558001700	phosphorylation site [posttranslational modification]
502558001701	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558001702	ATP binding site [chemical binding]; other site
502558001703	Mg2+ binding site [ion binding]; other site
502558001704	G-X-G motif; other site
502558001705	K+-transporting ATPase, c chain; Region: KdpC; cl00944
502558001706	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
502558001707	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
502558001708	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
502558001709	L-aspartate oxidase; Provisional; Region: PRK06175
502558001710	FAD binding domain; Region: FAD_binding_2; pfam00890
502558001711	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558001712	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558001713	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558001714	DNA binding residues [nucleotide binding]
502558001715	dimerization interface [polypeptide binding]; other site
502558001716	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
502558001717	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
502558001718	FMN binding site [chemical binding]; other site
502558001719	dimer interface [polypeptide binding]; other site
502558001720	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
502558001721	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
502558001722	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
502558001723	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558001724	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558001725	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558001726	H+ Antiporter protein; Region: 2A0121; TIGR00900
502558001727	putative substrate translocation pore; other site
502558001728	The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains.   LytC is composed of a...; Region: GH25_LytC-like; cd06414
502558001729	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
502558001730	active site
502558001731	Transglycosylase; Region: Transgly; pfam00912
502558001732	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
502558001733	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
502558001734	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
502558001735	Walker A/P-loop; other site
502558001736	ATP binding site [chemical binding]; other site
502558001737	Q-loop/lid; other site
502558001738	ABC transporter signature motif; other site
502558001739	Walker B; other site
502558001740	D-loop; other site
502558001741	H-loop/switch region; other site
502558001742	Predicted transcriptional regulators [Transcription]; Region: COG1725
502558001743	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
502558001744	DNA-binding site [nucleotide binding]; DNA binding site
502558001745	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
502558001746	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
502558001747	4Fe-4S binding domain; Region: Fer4; pfam00037
502558001748	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
502558001749	ArsC family; Region: ArsC; pfam03960
502558001750	putative ArsC-like catalytic residues; other site
502558001751	putative TRX-like catalytic residues [active]
502558001752	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
502558001753	putative active site [active]
502558001754	dimerization interface [polypeptide binding]; other site
502558001755	putative tRNAtyr binding site [nucleotide binding]; other site
502558001756	Flavodoxin domain; Region: Flavodoxin_3; pfam12641
502558001757	TfoX C-terminal domain; Region: TfoX_C; pfam04994
502558001758	Predicted integral membrane protein [Function unknown]; Region: COG5617
502558001759	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558001760	WHG domain; Region: WHG; pfam13305
502558001761	4Fe-4S binding domain; Region: Fer4_5; pfam12801
502558001762	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
502558001763	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
502558001764	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
502558001765	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
502558001766	DNA binding residues [nucleotide binding]
502558001767	dimer interface [polypeptide binding]; other site
502558001768	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
502558001769	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
502558001770	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
502558001771	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558001772	Walker A motif; other site
502558001773	ATP binding site [chemical binding]; other site
502558001774	Walker B motif; other site
502558001775	arginine finger; other site
502558001776	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
502558001777	metal ion-dependent adhesion site (MIDAS); other site
502558001778	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
502558001779	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
502558001780	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
502558001781	putative active site [active]
502558001782	homotetrameric interface [polypeptide binding]; other site
502558001783	metal binding site [ion binding]; metal-binding site
502558001784	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
502558001785	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
502558001786	Walker A/P-loop; other site
502558001787	ATP binding site [chemical binding]; other site
502558001788	Q-loop/lid; other site
502558001789	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
502558001790	ABC transporter signature motif; other site
502558001791	Walker B; other site
502558001792	D-loop; other site
502558001793	H-loop/switch region; other site
502558001794	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558001795	Major Facilitator Superfamily; Region: MFS_1; pfam07690
502558001796	putative substrate translocation pore; other site
502558001797	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558001798	FOG: CBS domain [General function prediction only]; Region: COG0517
502558001799	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
502558001800	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
502558001801	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
502558001802	Walker A/P-loop; other site
502558001803	ATP binding site [chemical binding]; other site
502558001804	Q-loop/lid; other site
502558001805	ABC transporter signature motif; other site
502558001806	Walker B; other site
502558001807	D-loop; other site
502558001808	H-loop/switch region; other site
502558001809	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
502558001810	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
502558001811	Walker A/P-loop; other site
502558001812	ATP binding site [chemical binding]; other site
502558001813	Q-loop/lid; other site
502558001814	ABC transporter signature motif; other site
502558001815	Walker B; other site
502558001816	D-loop; other site
502558001817	H-loop/switch region; other site
502558001818	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
502558001819	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
502558001820	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
502558001821	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
502558001822	B3/4 domain; Region: B3_4; pfam03483
502558001823	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
502558001824	putative active site [active]
502558001825	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
502558001826	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558001827	active site
502558001828	phosphorylation site [posttranslational modification]
502558001829	intermolecular recognition site; other site
502558001830	dimerization interface [polypeptide binding]; other site
502558001831	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
502558001832	DNA binding site [nucleotide binding]
502558001833	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
502558001834	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
502558001835	dimer interface [polypeptide binding]; other site
502558001836	phosphorylation site [posttranslational modification]
502558001837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558001838	ATP binding site [chemical binding]; other site
502558001839	Mg2+ binding site [ion binding]; other site
502558001840	G-X-G motif; other site
502558001841	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
502558001842	putative active site [active]
502558001843	endonuclease IV; Provisional; Region: PRK01060
502558001844	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
502558001845	AP (apurinic/apyrimidinic) site pocket; other site
502558001846	DNA interaction; other site
502558001847	Metal-binding active site; metal-binding site
502558001848	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
502558001849	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
502558001850	NAD(P) binding site [chemical binding]; other site
502558001851	catalytic residues [active]
502558001852	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
502558001853	metal binding site [ion binding]; metal-binding site
502558001854	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
502558001855	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
502558001856	active site
502558001857	NAD binding site [chemical binding]; other site
502558001858	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
502558001859	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
502558001860	protein binding site [polypeptide binding]; other site
502558001861	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
502558001862	putative nucleotide binding site [chemical binding]; other site
502558001863	uridine monophosphate binding site [chemical binding]; other site
502558001864	homohexameric interface [polypeptide binding]; other site
502558001865	ribosome recycling factor; Reviewed; Region: frr; PRK00083
502558001866	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
502558001867	hinge region; other site
502558001868	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
502558001869	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
502558001870	catalytic residue [active]
502558001871	putative FPP diphosphate  binding site; other site
502558001872	putative FPP binding hydrophobic cleft; other site
502558001873	dimer interface [polypeptide binding]; other site
502558001874	putative IPP diphosphate binding site; other site
502558001875	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
502558001876	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
502558001877	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
502558001878	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
502558001879	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
502558001880	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
502558001881	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
502558001882	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558001883	Walker A motif; other site
502558001884	ATP binding site [chemical binding]; other site
502558001885	Walker B motif; other site
502558001886	arginine finger; other site
502558001887	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
502558001888	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
502558001889	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
502558001890	transmembrane helices; other site
502558001891	Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086
502558001892	Ligand Binding Site [chemical binding]; other site
502558001893	Electron transfer flavoprotein domain; Region: ETF; pfam01012
502558001894	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
502558001895	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
502558001896	Ligand binding site [chemical binding]; other site
502558001897	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
502558001898	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
502558001899	CoA-transferase family III; Region: CoA_transf_3; pfam02515
502558001900	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
502558001901	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
502558001902	active site
502558001903	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
502558001904	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
502558001905	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558001906	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
502558001907	acyl-activating enzyme (AAE) consensus motif; other site
502558001908	AMP binding site [chemical binding]; other site
502558001909	active site
502558001910	CoA binding site [chemical binding]; other site
502558001911	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
502558001912	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
502558001913	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
502558001914	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
502558001915	PemK-like protein; Region: PemK; pfam02452
502558001916	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
502558001917	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
502558001918	active site
502558001919	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
502558001920	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
502558001921	putative substrate binding region [chemical binding]; other site
502558001922	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
502558001923	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
502558001924	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
502558001925	prolyl-tRNA synthetase; Provisional; Region: PRK09194
502558001926	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
502558001927	dimer interface [polypeptide binding]; other site
502558001928	motif 1; other site
502558001929	active site
502558001930	motif 2; other site
502558001931	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
502558001932	putative deacylase active site [active]
502558001933	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
502558001934	active site
502558001935	motif 3; other site
502558001936	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
502558001937	anticodon binding site; other site
502558001938	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
502558001939	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
502558001940	motif II; other site
502558001941	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558001942	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558001943	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
502558001944	dimerization interface [polypeptide binding]; other site
502558001945	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
502558001946	EamA-like transporter family; Region: EamA; pfam00892
502558001947	Uncharacterized conserved protein [Function unknown]; Region: COG3937
502558001948	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
502558001949	ABC1 family; Region: ABC1; cl17513
502558001950	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558001951	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558001952	non-specific DNA binding site [nucleotide binding]; other site
502558001953	salt bridge; other site
502558001954	sequence-specific DNA binding site [nucleotide binding]; other site
502558001955	ATP synthase I chain; Region: ATP_synt_I; cl09170
502558001956	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
502558001957	Predicted transcriptional regulators [Transcription]; Region: COG1725
502558001958	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
502558001959	DNA-binding site [nucleotide binding]; DNA binding site
502558001960	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
502558001961	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
502558001962	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
502558001963	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558001964	molybdopterin cofactor binding site; other site
502558001965	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
502558001966	molybdopterin cofactor binding site; other site
502558001967	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
502558001968	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
502558001969	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
502558001970	ATP binding site [chemical binding]; other site
502558001971	Mg++ binding site [ion binding]; other site
502558001972	motif III; other site
502558001973	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
502558001974	nucleotide binding region [chemical binding]; other site
502558001975	ATP-binding site [chemical binding]; other site
502558001976	Transcriptional regulator [Transcription]; Region: LytR; COG1316
502558001977	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
502558001978	Chain length determinant protein; Region: Wzz; cl15801
502558001979	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
502558001980	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
502558001981	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
502558001982	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 2; Region: NGN_Bact_2; cd09889
502558001983	Transcription antiterminator [Transcription]; Region: NusG; COG0250
502558001984	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
502558001985	heterodimer interface [polypeptide binding]; other site
502558001986	homodimer interface [polypeptide binding]; other site
502558001987	Bacterial sugar transferase; Region: Bac_transf; cl00939
502558001988	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
502558001989	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
502558001990	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
502558001991	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
502558001992	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
502558001993	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
502558001994	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
502558001995	active site
502558001996	homodimer interface [polypeptide binding]; other site
502558001997	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
502558001998	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
502558001999	putative acyl transferase; Provisional; Region: PRK10191
502558002000	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
502558002001	putative trimer interface [polypeptide binding]; other site
502558002002	putative CoA binding site [chemical binding]; other site
502558002003	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
502558002004	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
502558002005	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
502558002006	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
502558002007	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
502558002008	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
502558002009	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
502558002010	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
502558002011	dimer interface [polypeptide binding]; other site
502558002012	active site
502558002013	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
502558002014	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
502558002015	WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915
502558002016	Substrate binding site; other site
502558002017	Mg++ binding site; other site
502558002018	metal-binding site
502558002019	Mg++ binding site; other site
502558002020	metal-binding site
502558002021	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
502558002022	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
502558002023	active site
502558002024	motif I; other site
502558002025	motif II; other site
502558002026	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
502558002027	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
502558002028	NADP-binding site; other site
502558002029	homotetramer interface [polypeptide binding]; other site
502558002030	substrate binding site [chemical binding]; other site
502558002031	homodimer interface [polypeptide binding]; other site
502558002032	active site
502558002033	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
502558002034	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
502558002035	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
502558002036	catalytic residue [active]
502558002037	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
502558002038	NAD(P) binding site [chemical binding]; other site
502558002039	active site
502558002040	Fic family protein [Function unknown]; Region: COG3177
502558002041	Fic/DOC family; Region: Fic; pfam02661
502558002042	HTH domain; Region: HTH_11; pfam08279
502558002043	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
502558002044	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
502558002045	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
502558002046	YacP-like NYN domain; Region: NYN_YacP; pfam05991
502558002047	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
502558002048	Predicted membrane protein [Function unknown]; Region: COG1511
502558002049	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
502558002050	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558002051	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
502558002052	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
502558002053	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
502558002054	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
502558002055	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
502558002056	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
502558002057	RPB1 interaction site [polypeptide binding]; other site
502558002058	RPB10 interaction site [polypeptide binding]; other site
502558002059	RPB11 interaction site [polypeptide binding]; other site
502558002060	RPB3 interaction site [polypeptide binding]; other site
502558002061	RPB12 interaction site [polypeptide binding]; other site
502558002062	DNA-directed RNA polymerase subunit beta'/alpha domain fusion protein; Provisional; Region: PRK14906
502558002063	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
502558002064	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
502558002065	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
502558002066	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
502558002067	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
502558002068	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
502558002069	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
502558002070	G-loop; other site
502558002071	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
502558002072	DNA binding site [nucleotide binding]
502558002073	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
502558002074	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
502558002075	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
502558002076	metal binding site [ion binding]; metal-binding site
502558002077	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
502558002078	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
502558002079	active site
502558002080	substrate binding site [chemical binding]; other site
502558002081	metal binding site [ion binding]; metal-binding site
502558002082	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558002083	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
502558002084	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558002085	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558002086	DNA binding residues [nucleotide binding]
502558002087	dimerization interface [polypeptide binding]; other site
502558002088	polyphosphate kinase; Provisional; Region: PRK05443
502558002089	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
502558002090	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
502558002091	Catalytic C-terminal domain, first repeat, of uncharacterized prokaryotic polyphosphate kinases; Region: PLDc_PPK1_C1_unchar; cd09166
502558002092	putative domain interface [polypeptide binding]; other site
502558002093	putative active site [active]
502558002094	catalytic site [active]
502558002095	Catalytic C-terminal domain, second repeat, of uncharacterized prokaryotic polyphosphate kinases; Region: PLDc_PPK1_C2_unchar; cd09169
502558002096	putative domain interface [polypeptide binding]; other site
502558002097	putative active site [active]
502558002098	catalytic site [active]
502558002099	exopolyphosphatase; Region: exo_poly_only; TIGR03706
502558002100	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
502558002101	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
502558002102	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
502558002103	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
502558002104	active site
502558002105	catalytic site [active]
502558002106	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
502558002107	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
502558002108	dimerization interface [polypeptide binding]; other site
502558002109	putative ATP binding site [chemical binding]; other site
502558002110	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
502558002111	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
502558002112	active site
502558002113	substrate binding site [chemical binding]; other site
502558002114	cosubstrate binding site; other site
502558002115	catalytic site [active]
502558002116	Predicted permeases [General function prediction only]; Region: COG0679
502558002117	XdhC Rossmann domain; Region: XdhC_C; pfam13478
502558002118	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
502558002119	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
502558002120	purine monophosphate binding site [chemical binding]; other site
502558002121	dimer interface [polypeptide binding]; other site
502558002122	putative catalytic residues [active]
502558002123	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
502558002124	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
502558002125	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
502558002126	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
502558002127	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
502558002128	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558002129	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558002130	metal binding site [ion binding]; metal-binding site
502558002131	active site
502558002132	I-site; other site
502558002133	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
502558002134	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
502558002135	CoenzymeA binding site [chemical binding]; other site
502558002136	subunit interaction site [polypeptide binding]; other site
502558002137	PHB binding site; other site
502558002138	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
502558002139	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
502558002140	CoA-transferase family III; Region: CoA_transf_3; pfam02515
502558002141	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
502558002142	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
502558002143	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
502558002144	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
502558002145	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558002146	putative substrate translocation pore; other site
502558002147	Major Facilitator Superfamily; Region: MFS_1; pfam07690
502558002148	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
502558002149	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
502558002150	active site
502558002151	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
502558002152	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
502558002153	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558002154	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558002155	acyl-activating enzyme (AAE) consensus motif; other site
502558002156	AMP binding site [chemical binding]; other site
502558002157	active site
502558002158	CoA binding site [chemical binding]; other site
502558002159	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
502558002160	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
502558002161	active site
502558002162	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
502558002163	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
502558002164	Predicted acyl esterases [General function prediction only]; Region: COG2936
502558002165	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
502558002166	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558002167	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
502558002168	acyl carrier protein; Provisional; Region: acpP; PRK00982
502558002169	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
502558002170	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
502558002171	butyrate kinase; Provisional; Region: PRK03011
502558002172	MULE transposase domain; Region: MULE; pfam10551
502558002173	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
502558002174	FeS/SAM binding site; other site
502558002175	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
502558002176	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
502558002177	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
502558002178	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
502558002179	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
502558002180	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
502558002181	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
502558002182	dimer interface [polypeptide binding]; other site
502558002183	putative anticodon binding site; other site
502558002184	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
502558002185	motif 1; other site
502558002186	active site
502558002187	motif 2; other site
502558002188	motif 3; other site
502558002189	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
502558002190	dimer interface [polypeptide binding]; other site
502558002191	putative tRNA-binding site [nucleotide binding]; other site
502558002192	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
502558002193	Clp amino terminal domain; Region: Clp_N; pfam02861
502558002194	Clp amino terminal domain; Region: Clp_N; pfam02861
502558002195	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558002196	Walker A motif; other site
502558002197	ATP binding site [chemical binding]; other site
502558002198	Walker B motif; other site
502558002199	arginine finger; other site
502558002200	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558002201	Walker A motif; other site
502558002202	ATP binding site [chemical binding]; other site
502558002203	Walker B motif; other site
502558002204	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
502558002205	serine O-acetyltransferase; Region: cysE; TIGR01172
502558002206	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
502558002207	trimer interface [polypeptide binding]; other site
502558002208	active site
502558002209	substrate binding site [chemical binding]; other site
502558002210	CoA binding site [chemical binding]; other site
502558002211	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
502558002212	substrate binding site; other site
502558002213	dimer interface; other site
502558002214	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
502558002215	homotrimer interaction site [polypeptide binding]; other site
502558002216	zinc binding site [ion binding]; other site
502558002217	CDP-binding sites; other site
502558002218	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
502558002219	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
502558002220	active site
502558002221	HIGH motif; other site
502558002222	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
502558002223	KMSKS motif; other site
502558002224	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
502558002225	tRNA binding surface [nucleotide binding]; other site
502558002226	anticodon binding site; other site
502558002227	This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840
502558002228	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558002229	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558002230	DNA binding residues [nucleotide binding]
502558002231	dimerization interface [polypeptide binding]; other site
502558002232	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558002233	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558002234	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558002235	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
502558002236	Peptidase family U32; Region: Peptidase_U32; pfam01136
502558002237	TspO/MBR family; Region: TspO_MBR; cl01379
502558002238	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
502558002239	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
502558002240	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
502558002241	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
502558002242	active site
502558002243	putative substrate binding pocket [chemical binding]; other site
502558002244	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
502558002245	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
502558002246	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
502558002247	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
502558002248	dimer interface [polypeptide binding]; other site
502558002249	anticodon binding site; other site
502558002250	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
502558002251	homodimer interface [polypeptide binding]; other site
502558002252	motif 1; other site
502558002253	active site
502558002254	motif 2; other site
502558002255	GAD domain; Region: GAD; pfam02938
502558002256	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
502558002257	active site
502558002258	motif 3; other site
502558002259	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
502558002260	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
502558002261	FeS/SAM binding site; other site
502558002262	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
502558002263	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558002264	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558002265	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558002266	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558002267	DNA binding residues [nucleotide binding]
502558002268	dimerization interface [polypeptide binding]; other site
502558002269	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558002270	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
502558002271	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558002272	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
502558002273	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
502558002274	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
502558002275	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
502558002276	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558002277	Walker A motif; other site
502558002278	ATP binding site [chemical binding]; other site
502558002279	Walker B motif; other site
502558002280	arginine finger; other site
502558002281	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
502558002282	hypothetical protein; Validated; Region: PRK00153
502558002283	recombination protein RecR; Reviewed; Region: recR; PRK00076
502558002284	RecR protein; Region: RecR; pfam02132
502558002285	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
502558002286	putative active site [active]
502558002287	putative metal-binding site [ion binding]; other site
502558002288	tetramer interface [polypeptide binding]; other site
502558002289	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
502558002290	putative RNA binding site [nucleotide binding]; other site
502558002291	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
502558002292	AAA domain; Region: AAA_22; pfam13401
502558002293	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558002294	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558002295	DNA binding residues [nucleotide binding]
502558002296	dimerization interface [polypeptide binding]; other site
502558002297	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
502558002298	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558002299	molybdopterin cofactor binding site; other site
502558002300	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
502558002301	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
502558002302	4Fe-4S binding domain; Region: Fer4; pfam00037
502558002303	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
502558002304	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558002305	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558002306	DNA binding residues [nucleotide binding]
502558002307	hypothetical protein; Validated; Region: PRK07121
502558002308	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
502558002309	Walker A motif; other site
502558002310	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
502558002311	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
502558002312	GTP binding site; other site
502558002313	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
502558002314	4Fe-4S binding domain; Region: Fer4; pfam00037
502558002315	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
502558002316	Predicted transcriptional regulator [Transcription]; Region: COG1959
502558002317	Transcriptional regulator; Region: Rrf2; pfam02082
502558002318	Transcriptional regulator; Region: Rrf2; cl17282
502558002319	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
502558002320	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
502558002321	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
502558002322	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
502558002323	catalytic residues [active]
502558002324	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
502558002325	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
502558002326	substrate binding pocket [chemical binding]; other site
502558002327	membrane-bound complex binding site; other site
502558002328	hinge residues; other site
502558002329	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
502558002330	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
502558002331	dimer interface [polypeptide binding]; other site
502558002332	conserved gate region; other site
502558002333	putative PBP binding loops; other site
502558002334	ABC-ATPase subunit interface; other site
502558002335	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
502558002336	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
502558002337	Walker A/P-loop; other site
502558002338	ATP binding site [chemical binding]; other site
502558002339	Q-loop/lid; other site
502558002340	ABC transporter signature motif; other site
502558002341	Walker B; other site
502558002342	D-loop; other site
502558002343	H-loop/switch region; other site
502558002344	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
502558002345	putative deacylase active site [active]
502558002346	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
502558002347	catalytic core [active]
502558002348	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
502558002349	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
502558002350	classical (c) SDRs; Region: SDR_c; cd05233
502558002351	NAD(P) binding site [chemical binding]; other site
502558002352	active site
502558002353	H+ Antiporter protein; Region: 2A0121; TIGR00900
502558002354	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
502558002355	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
502558002356	DNA binding residues [nucleotide binding]
502558002357	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
502558002358	putrescine carbamoyltransferase; Provisional; Region: PRK02255
502558002359	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
502558002360	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
502558002361	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
502558002362	agmatine deiminase; Provisional; Region: PRK13551
502558002363	agmatine deiminase; Region: agmatine_aguA; TIGR03380
502558002364	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558002365	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558002366	DNA binding residues [nucleotide binding]
502558002367	dimerization interface [polypeptide binding]; other site
502558002368	putrescine carbamoyltransferase; Provisional; Region: PRK02255
502558002369	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
502558002370	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
502558002371	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
502558002372	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
502558002373	agmatine deiminase; Region: agmatine_aguA; TIGR03380
502558002374	carbamate kinase; Reviewed; Region: PRK12686
502558002375	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
502558002376	putative substrate binding site [chemical binding]; other site
502558002377	nucleotide binding site [chemical binding]; other site
502558002378	nucleotide binding site [chemical binding]; other site
502558002379	homodimer interface [polypeptide binding]; other site
502558002380	BRO family, N-terminal domain; Region: Bro-N; smart01040
502558002381	putrescine carbamoyltransferase; Provisional; Region: PRK02255
502558002382	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
502558002383	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
502558002384	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558002385	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558002386	DNA binding residues [nucleotide binding]
502558002387	dimerization interface [polypeptide binding]; other site
502558002388	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
502558002389	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
502558002390	NAD(P) binding site [chemical binding]; other site
502558002391	active site
502558002392	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
502558002393	LytTr DNA-binding domain; Region: LytTR; pfam04397
502558002394	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
502558002395	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
502558002396	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
502558002397	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558002398	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558002399	non-specific DNA binding site [nucleotide binding]; other site
502558002400	salt bridge; other site
502558002401	sequence-specific DNA binding site [nucleotide binding]; other site
502558002402	Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674
502558002403	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
502558002404	conserved cys residue [active]
502558002405	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
502558002406	Predicted transcriptional regulator [Transcription]; Region: COG2378
502558002407	HTH domain; Region: HTH_11; pfam08279
502558002408	WYL domain; Region: WYL; pfam13280
502558002409	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558002410	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558002411	DNA binding residues [nucleotide binding]
502558002412	dimerization interface [polypeptide binding]; other site
502558002413	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
502558002414	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558002415	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558002416	Bacterial SH3 domain; Region: SH3_3; pfam08239
502558002417	Bacterial SH3 domain; Region: SH3_3; pfam08239
502558002418	Bacterial SH3 domain; Region: SH3_3; pfam08239
502558002419	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
502558002420	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
502558002421	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
502558002422	dimer interface [polypeptide binding]; other site
502558002423	motif 1; other site
502558002424	active site
502558002425	motif 2; other site
502558002426	motif 3; other site
502558002427	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
502558002428	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
502558002429	putative tRNA-binding site [nucleotide binding]; other site
502558002430	B3/4 domain; Region: B3_4; pfam03483
502558002431	tRNA synthetase B5 domain; Region: B5; smart00874
502558002432	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
502558002433	dimer interface [polypeptide binding]; other site
502558002434	motif 1; other site
502558002435	motif 3; other site
502558002436	motif 2; other site
502558002437	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
502558002438	Uncharacterized conserved protein [Function unknown]; Region: COG0398
502558002439	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
502558002440	methionine aminopeptidase; Provisional; Region: PRK12318
502558002441	SEC-C motif; Region: SEC-C; pfam02810
502558002442	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
502558002443	active site
502558002444	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
502558002445	domain_subunit interface; other site
502558002446	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
502558002447	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
502558002448	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
502558002449	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
502558002450	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
502558002451	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
502558002452	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
502558002453	heterotetramer interface [polypeptide binding]; other site
502558002454	active site pocket [active]
502558002455	cleavage site
502558002456	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
502558002457	feedback inhibition sensing region; other site
502558002458	homohexameric interface [polypeptide binding]; other site
502558002459	nucleotide binding site [chemical binding]; other site
502558002460	N-acetyl-L-glutamate binding site [chemical binding]; other site
502558002461	acetylornithine aminotransferase; Provisional; Region: PRK02627
502558002462	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
502558002463	inhibitor-cofactor binding pocket; inhibition site
502558002464	pyridoxal 5'-phosphate binding site [chemical binding]; other site
502558002465	catalytic residue [active]
502558002466	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558002467	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558002468	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
502558002469	FAD binding domain; Region: FAD_binding_2; pfam00890
502558002470	Arginine repressor [Transcription]; Region: ArgR; COG1438
502558002471	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
502558002472	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
502558002473	argininosuccinate synthase; Provisional; Region: PRK13820
502558002474	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
502558002475	ANP binding site [chemical binding]; other site
502558002476	Substrate Binding Site II [chemical binding]; other site
502558002477	Substrate Binding Site I [chemical binding]; other site
502558002478	argininosuccinate lyase; Provisional; Region: PRK00855
502558002479	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
502558002480	active sites [active]
502558002481	tetramer interface [polypeptide binding]; other site
502558002482	Transglycosylase; Region: Transgly; pfam00912
502558002483	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
502558002484	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
502558002485	Transglycosylase; Region: Transgly; pfam00912
502558002486	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
502558002487	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
502558002488	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
502558002489	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
502558002490	Peptidase family U32; Region: Peptidase_U32; pfam01136
502558002491	Collagenase; Region: DUF3656; pfam12392
502558002492	Peptidase family U32; Region: Peptidase_U32; cl03113
502558002493	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
502558002494	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
502558002495	active site
502558002496	HIGH motif; other site
502558002497	dimer interface [polypeptide binding]; other site
502558002498	KMSKS motif; other site
502558002499	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
502558002500	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
502558002501	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
502558002502	DNA binding residues [nucleotide binding]
502558002503	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
502558002504	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
502558002505	NAD(P) binding site [chemical binding]; other site
502558002506	homodimer interface [polypeptide binding]; other site
502558002507	substrate binding site [chemical binding]; other site
502558002508	active site
502558002509	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
502558002510	active site
502558002511	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
502558002512	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
502558002513	active site
502558002514	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
502558002515	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
502558002516	putative sugar binding sites [chemical binding]; other site
502558002517	Q-X-W motif; other site
502558002518	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
502558002519	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
502558002520	putative sugar binding sites [chemical binding]; other site
502558002521	Q-X-W motif; other site
502558002522	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
502558002523	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
502558002524	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
502558002525	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
502558002526	putative sugar binding sites [chemical binding]; other site
502558002527	Q-X-W motif; other site
502558002528	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
502558002529	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
502558002530	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
502558002531	putative sugar binding sites [chemical binding]; other site
502558002532	Q-X-W motif; other site
502558002533	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
502558002534	Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439
502558002535	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
502558002536	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
502558002537	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
502558002538	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
502558002539	pseudaminic acid synthase; Region: PseI; TIGR03586
502558002540	NeuB family; Region: NeuB; pfam03102
502558002541	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
502558002542	NeuB binding interface [polypeptide binding]; other site
502558002543	putative substrate binding site [chemical binding]; other site
502558002544	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
502558002545	ligand binding site; other site
502558002546	tetramer interface; other site
502558002547	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
502558002548	active site
502558002549	catalytic residues [active]
502558002550	The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains.   LytC is composed of a...; Region: GH25_LytC-like; cd06414
502558002551	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
502558002552	active site
502558002553	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
502558002554	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
502558002555	putative sugar binding sites [chemical binding]; other site
502558002556	Q-X-W motif; other site
502558002557	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
502558002558	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
502558002559	putative sugar binding sites [chemical binding]; other site
502558002560	Q-X-W motif; other site
502558002561	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
502558002562	Ricin-type beta-trefoil; Region: RICIN; smart00458
502558002563	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
502558002564	putative sugar binding sites [chemical binding]; other site
502558002565	Q-X-W motif; other site
502558002566	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
502558002567	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
502558002568	NAD(P) binding site [chemical binding]; other site
502558002569	homodimer interface [polypeptide binding]; other site
502558002570	substrate binding site [chemical binding]; other site
502558002571	active site
502558002572	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
502558002573	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
502558002574	inhibitor-cofactor binding pocket; inhibition site
502558002575	pyridoxal 5'-phosphate binding site [chemical binding]; other site
502558002576	catalytic residue [active]
502558002577	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
502558002578	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
502558002579	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
502558002580	active site
502558002581	Protein of unknown function (DUF2766); Region: DUF2766; pfam10964
502558002582	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
502558002583	active site
502558002584	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
502558002585	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
502558002586	Ligand binding site; other site
502558002587	Putative Catalytic site; other site
502558002588	DXD motif; other site
502558002589	Uncharacterized conserved protein (DUF2304); Region: DUF2304; pfam10066
502558002590	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
502558002591	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
502558002592	substrate binding site; other site
502558002593	tetramer interface; other site
502558002594	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
502558002595	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
502558002596	NADP binding site [chemical binding]; other site
502558002597	active site
502558002598	putative substrate binding site [chemical binding]; other site
502558002599	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
502558002600	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
502558002601	NAD binding site [chemical binding]; other site
502558002602	substrate binding site [chemical binding]; other site
502558002603	homodimer interface [polypeptide binding]; other site
502558002604	active site
502558002605	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
502558002606	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
502558002607	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
502558002608	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
502558002609	Walker A/P-loop; other site
502558002610	ATP binding site [chemical binding]; other site
502558002611	Q-loop/lid; other site
502558002612	ABC transporter signature motif; other site
502558002613	Walker B; other site
502558002614	D-loop; other site
502558002615	H-loop/switch region; other site
502558002616	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
502558002617	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
502558002618	ABC-2 type transporter; Region: ABC2_membrane; cl17235
502558002619	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
502558002620	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
502558002621	active site
502558002622	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
502558002623	Transcriptional regulators [Transcription]; Region: MarR; COG1846
502558002624	putative switch regulator; other site
502558002625	non-specific DNA interactions [nucleotide binding]; other site
502558002626	DNA binding site [nucleotide binding]
502558002627	sequence specific DNA binding site [nucleotide binding]; other site
502558002628	putative cAMP binding site [chemical binding]; other site
502558002629	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
502558002630	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
502558002631	active site
502558002632	metal-binding site
502558002633	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
502558002634	active site
502558002635	substrate binding site [chemical binding]; other site
502558002636	ATP binding site [chemical binding]; other site
502558002637	Phosphotransferase enzyme family; Region: APH; pfam01636
502558002638	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
502558002639	60Kd inner membrane protein; Region: 60KD_IMP; pfam02096
502558002640	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
502558002641	Sulfatase; Region: Sulfatase; cl17466
502558002642	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
502558002643	Bacterial sugar transferase; Region: Bac_transf; pfam02397
502558002644	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
502558002645	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
502558002646	inhibitor-cofactor binding pocket; inhibition site
502558002647	pyridoxal 5'-phosphate binding site [chemical binding]; other site
502558002648	catalytic residue [active]
502558002649	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
502558002650	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
502558002651	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
502558002652	putative binding surface; other site
502558002653	active site
502558002654	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
502558002655	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
502558002656	Part of AAA domain; Region: AAA_19; pfam13245
502558002657	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
502558002658	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
502558002659	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
502558002660	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
502558002661	RNA/DNA hybrid binding site [nucleotide binding]; other site
502558002662	active site
502558002663	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
502558002664	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
502558002665	NlpC/P60 family; Region: NLPC_P60; pfam00877
502558002666	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
502558002667	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
502558002668	NlpC/P60 family; Region: NLPC_P60; cl17555
502558002669	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
502558002670	hypothetical protein; Provisional; Region: PRK13663
502558002671	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
502558002672	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
502558002673	active site
502558002674	Int/Topo IB signature motif; other site
502558002675	cell division protein MraZ; Reviewed; Region: PRK00326
502558002676	MraZ protein; Region: MraZ; pfam02381
502558002677	MraZ protein; Region: MraZ; pfam02381
502558002678	MraW methylase family; Region: Methyltransf_5; pfam01795
502558002679	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
502558002680	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
502558002681	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
502558002682	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
502558002683	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
502558002684	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
502558002685	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
502558002686	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
502558002687	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
502558002688	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
502558002689	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
502558002690	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
502558002691	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
502558002692	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
502558002693	Mg++ binding site [ion binding]; other site
502558002694	putative catalytic motif [active]
502558002695	putative substrate binding site [chemical binding]; other site
502558002696	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
502558002697	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
502558002698	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
502558002699	cell division protein FtsW; Region: ftsW; TIGR02614
502558002700	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
502558002701	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
502558002702	active site
502558002703	homodimer interface [polypeptide binding]; other site
502558002704	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
502558002705	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
502558002706	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
502558002707	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
502558002708	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
502558002709	FAD binding domain; Region: FAD_binding_4; pfam01565
502558002710	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
502558002711	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
502558002712	cell division protein FtsZ; Validated; Region: PRK09330
502558002713	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
502558002714	nucleotide binding site [chemical binding]; other site
502558002715	SulA interaction site; other site
502558002716	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
502558002717	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
502558002718	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
502558002719	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
502558002720	catalytic residue [active]
502558002721	Protein of unknown function (DUF552); Region: DUF552; pfam04472
502558002722	YGGT family; Region: YGGT; pfam02325
502558002723	DivIVA protein; Region: DivIVA; pfam05103
502558002724	DivIVA domain; Region: DivI1A_domain; TIGR03544
502558002725	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
502558002726	Thiamine pyrophosphokinase; Region: TPK; cd07995
502558002727	active site
502558002728	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
502558002729	dimerization interface [polypeptide binding]; other site
502558002730	thiamine binding site [chemical binding]; other site
502558002731	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
502558002732	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
502558002733	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
502558002734	substrate binding site [chemical binding]; other site
502558002735	multimerization interface [polypeptide binding]; other site
502558002736	ATP binding site [chemical binding]; other site
502558002737	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
502558002738	thiamine phosphate binding site [chemical binding]; other site
502558002739	active site
502558002740	pyrophosphate binding site [ion binding]; other site
502558002741	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
502558002742	dimer interface [polypeptide binding]; other site
502558002743	substrate binding site [chemical binding]; other site
502558002744	ATP binding site [chemical binding]; other site
502558002745	Cache domain; Region: Cache_1; pfam02743
502558002746	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
502558002747	dimerization interface [polypeptide binding]; other site
502558002748	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558002749	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558002750	metal binding site [ion binding]; metal-binding site
502558002751	active site
502558002752	I-site; other site
502558002753	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
502558002754	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
502558002755	active site
502558002756	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
502558002757	Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369
502558002758	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
502558002759	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
502558002760	CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704
502558002761	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
502558002762	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
502558002763	active site
502558002764	NTP binding site [chemical binding]; other site
502558002765	metal binding triad [ion binding]; metal-binding site
502558002766	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
502558002767	HD domain; Region: HD; pfam01966
502558002768	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
502558002769	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
502558002770	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
502558002771	active site
502558002772	trimer interface [polypeptide binding]; other site
502558002773	allosteric site; other site
502558002774	active site lid [active]
502558002775	hexamer (dimer of trimers) interface [polypeptide binding]; other site
502558002776	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
502558002777	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
502558002778	active site
502558002779	dimer interface [polypeptide binding]; other site
502558002780	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
502558002781	Protein of unknown function (DUF904); Region: DUF904; pfam06005
502558002782	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
502558002783	active site
502558002784	catalytic triad [active]
502558002785	dimer interface [polypeptide binding]; other site
502558002786	Putative Ig domain; Region: He_PIG; pfam05345
502558002787	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558002788	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558002789	DNA binding residues [nucleotide binding]
502558002790	dimerization interface [polypeptide binding]; other site
502558002791	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
502558002792	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
502558002793	dimerization interface [polypeptide binding]; other site
502558002794	putative active cleft [active]
502558002795	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
502558002796	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
502558002797	inhibitor site; inhibition site
502558002798	active site
502558002799	dimer interface [polypeptide binding]; other site
502558002800	catalytic residue [active]
502558002801	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
502558002802	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
502558002803	Walker A/P-loop; other site
502558002804	ATP binding site [chemical binding]; other site
502558002805	Q-loop/lid; other site
502558002806	ABC transporter signature motif; other site
502558002807	Walker B; other site
502558002808	D-loop; other site
502558002809	H-loop/switch region; other site
502558002810	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
502558002811	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
502558002812	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
502558002813	dimer interface [polypeptide binding]; other site
502558002814	conserved gate region; other site
502558002815	putative PBP binding loops; other site
502558002816	ABC-ATPase subunit interface; other site
502558002817	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
502558002818	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
502558002819	Walker A/P-loop; other site
502558002820	ATP binding site [chemical binding]; other site
502558002821	Q-loop/lid; other site
502558002822	ABC transporter signature motif; other site
502558002823	Walker B; other site
502558002824	D-loop; other site
502558002825	H-loop/switch region; other site
502558002826	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
502558002827	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
502558002828	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
502558002829	dimer interface [polypeptide binding]; other site
502558002830	conserved gate region; other site
502558002831	putative PBP binding loops; other site
502558002832	ABC-ATPase subunit interface; other site
502558002833	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
502558002834	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
502558002835	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
502558002836	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
502558002837	dimer interface [polypeptide binding]; other site
502558002838	PYR/PP interface [polypeptide binding]; other site
502558002839	TPP binding site [chemical binding]; other site
502558002840	substrate binding site [chemical binding]; other site
502558002841	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
502558002842	Domain of unknown function; Region: EKR; pfam10371
502558002843	4Fe-4S binding domain; Region: Fer4_6; pfam12837
502558002844	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
502558002845	TPP-binding site [chemical binding]; other site
502558002846	dimer interface [polypeptide binding]; other site
502558002847	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
502558002848	Beta-lactamase; Region: Beta-lactamase; pfam00144
502558002849	RelB antitoxin; Region: RelB; cl01171
502558002850	PIN domain; Region: PIN_3; pfam13470
502558002851	Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869
502558002852	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
502558002853	antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819
502558002854	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558002855	non-specific DNA binding site [nucleotide binding]; other site
502558002856	salt bridge; other site
502558002857	sequence-specific DNA binding site [nucleotide binding]; other site
502558002858	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
502558002859	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558002860	molybdopterin cofactor binding site; other site
502558002861	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
502558002862	molybdopterin cofactor binding site; other site
502558002863	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
502558002864	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
502558002865	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
502558002866	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
502558002867	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
502558002868	dimerization interface [polypeptide binding]; other site
502558002869	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
502558002870	dimer interface [polypeptide binding]; other site
502558002871	phosphorylation site [posttranslational modification]
502558002872	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558002873	ATP binding site [chemical binding]; other site
502558002874	Mg2+ binding site [ion binding]; other site
502558002875	G-X-G motif; other site
502558002876	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
502558002877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558002878	active site
502558002879	phosphorylation site [posttranslational modification]
502558002880	intermolecular recognition site; other site
502558002881	dimerization interface [polypeptide binding]; other site
502558002882	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
502558002883	DNA binding site [nucleotide binding]
502558002884	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
502558002885	FeS/SAM binding site; other site
502558002886	Radical SAM superfamily; Region: Radical_SAM; pfam04055
502558002887	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
502558002888	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
502558002889	active site
502558002890	FMN binding site [chemical binding]; other site
502558002891	substrate binding site [chemical binding]; other site
502558002892	putative catalytic residue [active]
502558002893	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
502558002894	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558002895	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558002896	DNA binding residues [nucleotide binding]
502558002897	dimerization interface [polypeptide binding]; other site
502558002898	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
502558002899	classical (c) SDRs; Region: SDR_c; cd05233
502558002900	NAD(P) binding site [chemical binding]; other site
502558002901	active site
502558002902	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
502558002903	active site
502558002904	metal binding site [ion binding]; metal-binding site
502558002905	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558002906	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558002907	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
502558002908	dimerization interface [polypeptide binding]; other site
502558002909	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
502558002910	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
502558002911	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
502558002912	catalytic residue [active]
502558002913	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558002914	putative substrate translocation pore; other site
502558002915	Major Facilitator Superfamily; Region: MFS_1; pfam07690
502558002916	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
502558002917	CoA-transferase family III; Region: CoA_transf_3; pfam02515
502558002918	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
502558002919	enoyl-CoA hydratase; Provisional; Region: PRK08252
502558002920	substrate binding site [chemical binding]; other site
502558002921	oxyanion hole (OAH) forming residues; other site
502558002922	trimer interface [polypeptide binding]; other site
502558002923	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558002924	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558002925	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
502558002926	dimerization interface [polypeptide binding]; other site
502558002927	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
502558002928	substrate binding site [chemical binding]; other site
502558002929	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
502558002930	putative active site [active]
502558002931	elongation factor Tu; Reviewed; Region: PRK00049
502558002932	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
502558002933	G1 box; other site
502558002934	GEF interaction site [polypeptide binding]; other site
502558002935	GTP/Mg2+ binding site [chemical binding]; other site
502558002936	Switch I region; other site
502558002937	G2 box; other site
502558002938	G3 box; other site
502558002939	Switch II region; other site
502558002940	G4 box; other site
502558002941	G5 box; other site
502558002942	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
502558002943	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
502558002944	Antibiotic Binding Site [chemical binding]; other site
502558002945	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
502558002946	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
502558002947	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
502558002948	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
502558002949	putative homodimer interface [polypeptide binding]; other site
502558002950	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
502558002951	heterodimer interface [polypeptide binding]; other site
502558002952	homodimer interface [polypeptide binding]; other site
502558002953	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
502558002954	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
502558002955	23S rRNA interface [nucleotide binding]; other site
502558002956	L7/L12 interface [polypeptide binding]; other site
502558002957	putative thiostrepton binding site; other site
502558002958	L25 interface [polypeptide binding]; other site
502558002959	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
502558002960	mRNA/rRNA interface [nucleotide binding]; other site
502558002961	Bacterial Ig-like domain; Region: Big_5; pfam13205
502558002962	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
502558002963	active site
502558002964	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
502558002965	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
502558002966	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
502558002967	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
502558002968	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
502558002969	G1 box; other site
502558002970	GTP/Mg2+ binding site [chemical binding]; other site
502558002971	Switch I region; other site
502558002972	G2 box; other site
502558002973	G3 box; other site
502558002974	Switch II region; other site
502558002975	G4 box; other site
502558002976	G5 box; other site
502558002977	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
502558002978	rRNA interaction site [nucleotide binding]; other site
502558002979	S8 interaction site; other site
502558002980	putative laminin-1 binding site; other site
502558002981	elongation factor Ts; Provisional; Region: tsf; PRK09377
502558002982	UBA/TS-N domain; Region: UBA; pfam00627
502558002983	Elongation factor TS; Region: EF_TS; pfam00889
502558002984	Elongation factor TS; Region: EF_TS; pfam00889
502558002985	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
502558002986	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
502558002987	hinge; other site
502558002988	active site
502558002989	Transcriptional regulator [Transcription]; Region: LytR; COG1316
502558002990	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
502558002991	NifU-like domain; Region: NifU; pfam01106
502558002992	Uncharacterized archaeal Zn-finger protein [General function prediction only]; Region: COG1326
502558002993	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
502558002994	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018
502558002995	non-heme iron binding site [ion binding]; other site
502558002996	Desulfoferrodoxin [Energy production and conversion]; Region: COG2033
502558002997	dimer interface [polypeptide binding]; other site
502558002998	Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880
502558002999	non-heme iron binding site [ion binding]; other site
502558003000	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
502558003001	intersubunit interface [polypeptide binding]; other site
502558003002	active site
502558003003	Zn2+ binding site [ion binding]; other site
502558003004	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
502558003005	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
502558003006	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
502558003007	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
502558003008	Rubredoxin [Energy production and conversion]; Region: COG1773
502558003009	iron binding site [ion binding]; other site
502558003010	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
502558003011	S-adenosylmethionine binding site [chemical binding]; other site
502558003012	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
502558003013	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
502558003014	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
502558003015	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
502558003016	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558003017	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
502558003018	Walker A/P-loop; other site
502558003019	ATP binding site [chemical binding]; other site
502558003020	Q-loop/lid; other site
502558003021	ABC transporter signature motif; other site
502558003022	Walker B; other site
502558003023	D-loop; other site
502558003024	H-loop/switch region; other site
502558003025	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
502558003026	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
502558003027	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
502558003028	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
502558003029	Walker A/P-loop; other site
502558003030	ATP binding site [chemical binding]; other site
502558003031	Q-loop/lid; other site
502558003032	ABC transporter signature motif; other site
502558003033	Walker B; other site
502558003034	D-loop; other site
502558003035	H-loop/switch region; other site
502558003036	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
502558003037	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
502558003038	substrate binding pocket [chemical binding]; other site
502558003039	membrane-bound complex binding site; other site
502558003040	hinge residues; other site
502558003041	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
502558003042	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
502558003043	dimer interface [polypeptide binding]; other site
502558003044	conserved gate region; other site
502558003045	putative PBP binding loops; other site
502558003046	ABC-ATPase subunit interface; other site
502558003047	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
502558003048	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
502558003049	dimer interface [polypeptide binding]; other site
502558003050	conserved gate region; other site
502558003051	putative PBP binding loops; other site
502558003052	ABC-ATPase subunit interface; other site
502558003053	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
502558003054	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558003055	non-specific DNA binding site [nucleotide binding]; other site
502558003056	salt bridge; other site
502558003057	sequence-specific DNA binding site [nucleotide binding]; other site
502558003058	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
502558003059	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
502558003060	DNA topoisomerase I; Validated; Region: PRK07219
502558003061	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
502558003062	active site
502558003063	putative interdomain interaction site [polypeptide binding]; other site
502558003064	putative metal-binding site [ion binding]; other site
502558003065	putative nucleotide binding site [chemical binding]; other site
502558003066	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
502558003067	domain I; other site
502558003068	DNA binding groove [nucleotide binding]
502558003069	phosphate binding site [ion binding]; other site
502558003070	domain II; other site
502558003071	domain III; other site
502558003072	nucleotide binding site [chemical binding]; other site
502558003073	catalytic site [active]
502558003074	domain IV; other site
502558003075	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
502558003076	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
502558003077	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
502558003078	transmembrane helices; other site
502558003079	fumarate hydratase; Provisional; Region: PRK06246
502558003080	Fumarase C-terminus; Region: Fumerase_C; cl00795
502558003081	L-aspartate oxidase; Provisional; Region: PRK06175
502558003082	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812
502558003083	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
502558003084	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
502558003085	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
502558003086	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
502558003087	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
502558003088	Cysteine-rich domain; Region: CCG; pfam02754
502558003089	Cysteine-rich domain; Region: CCG; pfam02754
502558003090	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
502558003091	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
502558003092	DNA binding residues [nucleotide binding]
502558003093	dimerization interface [polypeptide binding]; other site
502558003094	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
502558003095	Malic enzyme, N-terminal domain; Region: malic; pfam00390
502558003096	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
502558003097	putative NAD(P) binding site [chemical binding]; other site
502558003098	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
502558003099	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
502558003100	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
502558003101	FMN binding site [chemical binding]; other site
502558003102	dimer interface [polypeptide binding]; other site
502558003103	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
502558003104	Fumarase C-terminus; Region: Fumerase_C; cl00795
502558003105	thymidylate kinase; Validated; Region: tmk; PRK00698
502558003106	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
502558003107	TMP-binding site; other site
502558003108	ATP-binding site [chemical binding]; other site
502558003109	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
502558003110	DNA polymerase III subunit delta'; Validated; Region: PRK08485
502558003111	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
502558003112	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
502558003113	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
502558003114	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
502558003115	active site
502558003116	EDD domain protein, DegV family; Region: DegV; TIGR00762
502558003117	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
502558003118	EDD domain protein, DegV family; Region: DegV; TIGR00762
502558003119	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
502558003120	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
502558003121	Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313
502558003122	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
502558003123	FeS/SAM binding site; other site
502558003124	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
502558003125	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
502558003126	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
502558003127	FeS/SAM binding site; other site
502558003128	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
502558003129	catalytic residues [active]
502558003130	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
502558003131	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
502558003132	putative active site [active]
502558003133	catalytic triad [active]
502558003134	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
502558003135	putative active site [active]
502558003136	catalytic triad [active]
502558003137	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
502558003138	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
502558003139	active site
502558003140	catalytic residues [active]
502558003141	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
502558003142	catalytic residues [active]
502558003143	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
502558003144	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
502558003145	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
502558003146	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
502558003147	putative FMN binding site [chemical binding]; other site
502558003148	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
502558003149	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558003150	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558003151	non-specific DNA binding site [nucleotide binding]; other site
502558003152	salt bridge; other site
502558003153	sequence-specific DNA binding site [nucleotide binding]; other site
502558003154	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
502558003155	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
502558003156	Walker A/P-loop; other site
502558003157	ATP binding site [chemical binding]; other site
502558003158	Q-loop/lid; other site
502558003159	ABC transporter signature motif; other site
502558003160	Walker B; other site
502558003161	D-loop; other site
502558003162	H-loop/switch region; other site
502558003163	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
502558003164	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
502558003165	histone acetyltransferase, ELP3 family; Region: ELP3; TIGR01211
502558003166	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
502558003167	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
502558003168	S-adenosylmethionine binding site [chemical binding]; other site
502558003169	Protein of unknown function (DUF3810); Region: DUF3810; pfam12725
502558003170	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
502558003171	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
502558003172	iron-sulfur cluster [ion binding]; other site
502558003173	[2Fe-2S] cluster binding site [ion binding]; other site
502558003174	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
502558003175	hydrophobic ligand binding site; other site
502558003176	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
502558003177	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
502558003178	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
502558003179	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
502558003180	active site
502558003181	flavodoxin; Provisional; Region: PRK07116
502558003182	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
502558003183	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
502558003184	active site
502558003185	catalytic tetrad [active]
502558003186	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
502558003187	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558003188	putative substrate translocation pore; other site
502558003189	Major Facilitator Superfamily; Region: MFS_1; pfam07690
502558003190	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558003191	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558003192	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
502558003193	dimerization interface [polypeptide binding]; other site
502558003194	Domain of unknown function (DUF362); Region: DUF362; pfam04015
502558003195	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
502558003196	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558003197	non-specific DNA binding site [nucleotide binding]; other site
502558003198	salt bridge; other site
502558003199	sequence-specific DNA binding site [nucleotide binding]; other site
502558003200	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
502558003201	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
502558003202	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
502558003203	active site
502558003204	catalytic tetrad [active]
502558003205	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
502558003206	Predicted transcriptional regulators [Transcription]; Region: COG1733
502558003207	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
502558003208	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
502558003209	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
502558003210	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
502558003211	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
502558003212	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
502558003213	homotetramer interface [polypeptide binding]; other site
502558003214	ligand binding site [chemical binding]; other site
502558003215	catalytic site [active]
502558003216	NAD binding site [chemical binding]; other site
502558003217	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
502558003218	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
502558003219	DXD motif; other site
502558003220	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
502558003221	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
502558003222	active site
502558003223	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
502558003224	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
502558003225	substrate binding pocket [chemical binding]; other site
502558003226	membrane-bound complex binding site; other site
502558003227	hinge residues; other site
502558003228	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558003229	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558003230	LysR substrate binding domain; Region: LysR_substrate; pfam03466
502558003231	dimerization interface [polypeptide binding]; other site
502558003232	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
502558003233	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
502558003234	Ligand binding site [chemical binding]; other site
502558003235	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
502558003236	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
502558003237	Ligand Binding Site [chemical binding]; other site
502558003238	Electron transfer flavoprotein domain; Region: ETF; pfam01012
502558003239	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
502558003240	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
502558003241	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
502558003242	active site
502558003243	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
502558003244	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
502558003245	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
502558003246	active site
502558003247	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
502558003248	AIR carboxylase; Region: AIRC; smart01001
502558003249	Protein of unknown function DUF111; Region: DUF111; cl03398
502558003250	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
502558003251	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
502558003252	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
502558003253	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558003254	Walker A/P-loop; other site
502558003255	ATP binding site [chemical binding]; other site
502558003256	Q-loop/lid; other site
502558003257	ABC transporter signature motif; other site
502558003258	Walker B; other site
502558003259	D-loop; other site
502558003260	H-loop/switch region; other site
502558003261	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
502558003262	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
502558003263	Peptidase M16C associated; Region: M16C_assoc; pfam08367
502558003264	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
502558003265	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
502558003266	Walker A/P-loop; other site
502558003267	ATP binding site [chemical binding]; other site
502558003268	Q-loop/lid; other site
502558003269	ABC transporter signature motif; other site
502558003270	Walker B; other site
502558003271	D-loop; other site
502558003272	H-loop/switch region; other site
502558003273	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
502558003274	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
502558003275	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
502558003276	Walker A/P-loop; other site
502558003277	ATP binding site [chemical binding]; other site
502558003278	Q-loop/lid; other site
502558003279	ABC transporter signature motif; other site
502558003280	Walker B; other site
502558003281	D-loop; other site
502558003282	H-loop/switch region; other site
502558003283	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
502558003284	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
502558003285	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
502558003286	dimer interface [polypeptide binding]; other site
502558003287	conserved gate region; other site
502558003288	ABC-ATPase subunit interface; other site
502558003289	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
502558003290	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
502558003291	putative PBP binding loops; other site
502558003292	dimer interface [polypeptide binding]; other site
502558003293	ABC-ATPase subunit interface; other site
502558003294	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
502558003295	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
502558003296	peptide binding site [polypeptide binding]; other site
502558003297	DAK2 domain; Region: Dak2; pfam02734
502558003298	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
502558003299	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
502558003300	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
502558003301	intersubunit interface [polypeptide binding]; other site
502558003302	active site
502558003303	zinc binding site [ion binding]; other site
502558003304	Na+ binding site [ion binding]; other site
502558003305	pyruvate kinase; Provisional; Region: PRK05826
502558003306	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
502558003307	domain interfaces; other site
502558003308	active site
502558003309	Protein of unknown function (DUF454); Region: DUF454; cl01063
502558003310	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
502558003311	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
502558003312	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
502558003313	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
502558003314	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
502558003315	23S rRNA binding site [nucleotide binding]; other site
502558003316	L21 binding site [polypeptide binding]; other site
502558003317	L13 binding site [polypeptide binding]; other site
502558003318	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
502558003319	Predicted dehydrogenase [General function prediction only]; Region: COG0579
502558003320	hydroxyglutarate oxidase; Provisional; Region: PRK11728
502558003321	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
502558003322	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
502558003323	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
502558003324	Protein of unknown function (DUF1667); Region: DUF1667; cl17602
502558003325	helicase 45; Provisional; Region: PTZ00424
502558003326	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
502558003327	ATP binding site [chemical binding]; other site
502558003328	Mg++ binding site [ion binding]; other site
502558003329	motif III; other site
502558003330	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
502558003331	nucleotide binding region [chemical binding]; other site
502558003332	ATP-binding site [chemical binding]; other site
502558003333	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
502558003334	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
502558003335	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
502558003336	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
502558003337	Ligand binding site; other site
502558003338	Putative Catalytic site; other site
502558003339	DXD motif; other site
502558003340	Predicted membrane protein [Function unknown]; Region: COG2246
502558003341	GtrA-like protein; Region: GtrA; pfam04138
502558003342	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
502558003343	TRAM domain; Region: TRAM; pfam01938
502558003344	Helix-turn-helix domain; Region: HTH_17; pfam12728
502558003345	D5 N terminal like; Region: D5_N; smart00885
502558003346	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
502558003347	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
502558003348	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
502558003349	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
502558003350	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
502558003351	P-loop; other site
502558003352	Magnesium ion binding site [ion binding]; other site
502558003353	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
502558003354	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
502558003355	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
502558003356	ATP binding site [chemical binding]; other site
502558003357	putative Mg++ binding site [ion binding]; other site
502558003358	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
502558003359	HsdM N-terminal domain; Region: HsdM_N; pfam12161
502558003360	Methyltransferase domain; Region: Methyltransf_26; pfam13659
502558003361	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
502558003362	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
502558003363	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
502558003364	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
502558003365	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
502558003366	catalytic residues [active]
502558003367	catalytic nucleophile [active]
502558003368	Recombinase; Region: Recombinase; pfam07508
502558003369	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
502558003370	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
502558003371	transmembrane helices; other site
502558003372	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
502558003373	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558003374	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558003375	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
502558003376	dimerization interface [polypeptide binding]; other site
502558003377	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
502558003378	classical (c) SDRs; Region: SDR_c; cd05233
502558003379	NAD(P) binding site [chemical binding]; other site
502558003380	active site
502558003381	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
502558003382	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
502558003383	NAD(P) binding site [chemical binding]; other site
502558003384	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
502558003385	CoA-transferase family III; Region: CoA_transf_3; pfam02515
502558003386	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
502558003387	CoA-transferase family III; Region: CoA_transf_3; pfam02515
502558003388	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
502558003389	active site
502558003390	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
502558003391	binding surface
502558003392	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
502558003393	TPR motif; other site
502558003394	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
502558003395	binding surface
502558003396	TPR motif; other site
502558003397	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
502558003398	binding surface
502558003399	TPR motif; other site
502558003400	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
502558003401	active site
502558003402	multimer interface [polypeptide binding]; other site
502558003403	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
502558003404	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
502558003405	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
502558003406	FAD binding pocket [chemical binding]; other site
502558003407	FAD binding motif [chemical binding]; other site
502558003408	phosphate binding motif [ion binding]; other site
502558003409	beta-alpha-beta structure motif; other site
502558003410	NAD binding pocket [chemical binding]; other site
502558003411	Iron coordination center [ion binding]; other site
502558003412	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
502558003413	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
502558003414	rod shape-determining protein MreB; Provisional; Region: PRK13927
502558003415	MreB and similar proteins; Region: MreB_like; cd10225
502558003416	nucleotide binding site [chemical binding]; other site
502558003417	Mg binding site [ion binding]; other site
502558003418	putative protofilament interaction site [polypeptide binding]; other site
502558003419	RodZ interaction site [polypeptide binding]; other site
502558003420	rod shape-determining protein MreC; Provisional; Region: PRK13922
502558003421	rod shape-determining protein MreC; Region: MreC; pfam04085
502558003422	rod shape-determining protein MreD; Region: MreD; cl01087
502558003423	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
502558003424	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
502558003425	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
502558003426	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
502558003427	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
502558003428	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
502558003429	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
502558003430	B12 binding site [chemical binding]; other site
502558003431	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
502558003432	FeS/SAM binding site; other site
502558003433	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
502558003434	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
502558003435	Transcriptional regulators [Transcription]; Region: MarR; COG1846
502558003436	MarR family; Region: MarR_2; pfam12802
502558003437	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
502558003438	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558003439	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
502558003440	Walker A/P-loop; other site
502558003441	ATP binding site [chemical binding]; other site
502558003442	Q-loop/lid; other site
502558003443	ABC transporter signature motif; other site
502558003444	Walker B; other site
502558003445	D-loop; other site
502558003446	H-loop/switch region; other site
502558003447	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
502558003448	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
502558003449	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558003450	Walker A/P-loop; other site
502558003451	ATP binding site [chemical binding]; other site
502558003452	Q-loop/lid; other site
502558003453	ABC transporter signature motif; other site
502558003454	Walker B; other site
502558003455	D-loop; other site
502558003456	H-loop/switch region; other site
502558003457	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
502558003458	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
502558003459	Rrf2 family protein; Region: rrf2_super; TIGR00738
502558003460	Transcriptional regulator; Region: Rrf2; pfam02082
502558003461	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
502558003462	endonuclease III; Region: ENDO3c; smart00478
502558003463	minor groove reading motif; other site
502558003464	helix-hairpin-helix signature motif; other site
502558003465	substrate binding pocket [chemical binding]; other site
502558003466	active site
502558003467	Predicted membrane protein [Function unknown]; Region: COG1971
502558003468	Domain of unknown function DUF; Region: DUF204; pfam02659
502558003469	Domain of unknown function DUF; Region: DUF204; pfam02659
502558003470	prephenate dehydratase; Provisional; Region: PRK11898
502558003471	Prephenate dehydratase; Region: PDT; pfam00800
502558003472	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
502558003473	putative L-Phe binding site [chemical binding]; other site
502558003474	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
502558003475	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
502558003476	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
502558003477	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
502558003478	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
502558003479	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
502558003480	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
502558003481	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
502558003482	nickel binding site [ion binding]; other site
502558003483	Protein of unknown function, DUF488; Region: DUF488; cl01246
502558003484	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
502558003485	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
502558003486	putative active site [active]
502558003487	Domain of unknown function (DUF362); Region: DUF362; pfam04015
502558003488	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
502558003489	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
502558003490	minor groove reading motif; other site
502558003491	helix-hairpin-helix signature motif; other site
502558003492	substrate binding pocket [chemical binding]; other site
502558003493	active site
502558003494	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
502558003495	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
502558003496	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
502558003497	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
502558003498	ATP binding site [chemical binding]; other site
502558003499	putative Mg++ binding site [ion binding]; other site
502558003500	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
502558003501	nucleotide binding region [chemical binding]; other site
502558003502	ATP-binding site [chemical binding]; other site
502558003503	TRCF domain; Region: TRCF; pfam03461
502558003504	EamA-like transporter family; Region: EamA; pfam00892
502558003505	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
502558003506	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
502558003507	active site
502558003508	dimer interface [polypeptide binding]; other site
502558003509	MarR family; Region: MarR_2; pfam12802
502558003510	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
502558003511	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
502558003512	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
502558003513	CoenzymeA binding site [chemical binding]; other site
502558003514	subunit interaction site [polypeptide binding]; other site
502558003515	PHB binding site; other site
502558003516	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
502558003517	4Fe-4S binding domain; Region: Fer4; pfam00037
502558003518	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
502558003519	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
502558003520	HIGH motif; other site
502558003521	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
502558003522	active site
502558003523	KMSKS motif; other site
502558003524	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
502558003525	S-adenosylmethionine synthetase; Validated; Region: PRK05250
502558003526	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
502558003527	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
502558003528	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
502558003529	primosome assembly protein PriA; Validated; Region: PRK05580
502558003530	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
502558003531	ATP binding site [chemical binding]; other site
502558003532	putative Mg++ binding site [ion binding]; other site
502558003533	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
502558003534	helicase superfamily c-terminal domain; Region: HELICc; smart00490
502558003535	ATP-binding site [chemical binding]; other site
502558003536	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
502558003537	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
502558003538	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
502558003539	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
502558003540	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
502558003541	DNA binding residues [nucleotide binding]
502558003542	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
502558003543	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
502558003544	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
502558003545	S-adenosylmethionine binding site [chemical binding]; other site
502558003546	Predicted membrane protein [Function unknown]; Region: COG2364
502558003547	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
502558003548	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
502558003549	active site
502558003550	HIGH motif; other site
502558003551	dimer interface [polypeptide binding]; other site
502558003552	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
502558003553	KMSKS motif; other site
502558003554	ribosome maturation protein RimP; Reviewed; Region: PRK00092
502558003555	Sm and related proteins; Region: Sm_like; cl00259
502558003556	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
502558003557	putative oligomer interface [polypeptide binding]; other site
502558003558	putative RNA binding site [nucleotide binding]; other site
502558003559	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
502558003560	NusA N-terminal domain; Region: NusA_N; pfam08529
502558003561	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
502558003562	RNA binding site [nucleotide binding]; other site
502558003563	homodimer interface [polypeptide binding]; other site
502558003564	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
502558003565	G-X-X-G motif; other site
502558003566	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
502558003567	G-X-X-G motif; other site
502558003568	Protein of unknown function (DUF448); Region: DUF448; pfam04296
502558003569	putative RNA binding cleft [nucleotide binding]; other site
502558003570	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
502558003571	translation initiation factor IF-2; Region: IF-2; TIGR00487
502558003572	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
502558003573	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
502558003574	G1 box; other site
502558003575	putative GEF interaction site [polypeptide binding]; other site
502558003576	GTP/Mg2+ binding site [chemical binding]; other site
502558003577	Switch I region; other site
502558003578	G2 box; other site
502558003579	G3 box; other site
502558003580	Switch II region; other site
502558003581	G4 box; other site
502558003582	G5 box; other site
502558003583	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
502558003584	Translation-initiation factor 2; Region: IF-2; pfam11987
502558003585	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
502558003586	Ribosome-binding factor A; Region: RBFA; pfam02033
502558003587	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
502558003588	DHH family; Region: DHH; pfam01368
502558003589	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
502558003590	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
502558003591	RNA binding site [nucleotide binding]; other site
502558003592	active site
502558003593	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
502558003594	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
502558003595	active site
502558003596	Riboflavin kinase; Region: Flavokinase; smart00904
502558003597	Sulfatase; Region: Sulfatase; cl17466
502558003598	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
502558003599	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
502558003600	glutamate dehydrogenase; Provisional; Region: PRK09414
502558003601	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
502558003602	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
502558003603	NAD(P) binding site [chemical binding]; other site
502558003604	benzoate transport; Region: 2A0115; TIGR00895
502558003605	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558003606	putative substrate translocation pore; other site
502558003607	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558003608	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
502558003609	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
502558003610	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
502558003611	FAD binding domain; Region: FAD_binding_4; pfam01565
502558003612	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
502558003613	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
502558003614	FIC domain binding interface [polypeptide binding]; other site
502558003615	Fic/DOC family; Region: Fic; pfam02661
502558003616	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
502558003617	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
502558003618	GIY-YIG motif/motif A; other site
502558003619	active site
502558003620	catalytic site [active]
502558003621	putative DNA binding site [nucleotide binding]; other site
502558003622	metal binding site [ion binding]; metal-binding site
502558003623	UvrB/uvrC motif; Region: UVR; pfam02151
502558003624	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
502558003625	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
502558003626	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
502558003627	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
502558003628	phosphate binding site [ion binding]; other site
502558003629	putative substrate binding pocket [chemical binding]; other site
502558003630	dimer interface [polypeptide binding]; other site
502558003631	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
502558003632	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
502558003633	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
502558003634	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
502558003635	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
502558003636	Phosphoglycerate kinase; Region: PGK; pfam00162
502558003637	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
502558003638	substrate binding site [chemical binding]; other site
502558003639	hinge regions; other site
502558003640	ADP binding site [chemical binding]; other site
502558003641	catalytic site [active]
502558003642	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
502558003643	triosephosphate isomerase; Provisional; Region: PRK14565
502558003644	substrate binding site [chemical binding]; other site
502558003645	dimer interface [polypeptide binding]; other site
502558003646	catalytic triad [active]
502558003647	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
502558003648	phosphoglyceromutase; Provisional; Region: PRK05434
502558003649	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
502558003650	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
502558003651	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
502558003652	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
502558003653	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
502558003654	motif II; other site
502558003655	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
502558003656	DEAD-like helicases superfamily; Region: DEXDc; smart00487
502558003657	ATP binding site [chemical binding]; other site
502558003658	Mg++ binding site [ion binding]; other site
502558003659	motif III; other site
502558003660	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
502558003661	nucleotide binding region [chemical binding]; other site
502558003662	ATP-binding site [chemical binding]; other site
502558003663	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
502558003664	GAF domain; Region: GAF; pfam01590
502558003665	Histidine kinase; Region: HisKA_3; pfam07730
502558003666	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
502558003667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558003668	ATP binding site [chemical binding]; other site
502558003669	Mg2+ binding site [ion binding]; other site
502558003670	G-X-G motif; other site
502558003671	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558003672	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558003673	active site
502558003674	phosphorylation site [posttranslational modification]
502558003675	intermolecular recognition site; other site
502558003676	dimerization interface [polypeptide binding]; other site
502558003677	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558003678	DNA binding residues [nucleotide binding]
502558003679	dimerization interface [polypeptide binding]; other site
502558003680	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
502558003681	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
502558003682	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
502558003683	ribonuclease D; Region: rnd; TIGR01388
502558003684	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
502558003685	catalytic site [active]
502558003686	putative active site [active]
502558003687	putative substrate binding site [chemical binding]; other site
502558003688	HRDC domain; Region: HRDC; pfam00570
502558003689	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
502558003690	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
502558003691	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
502558003692	generic binding surface II; other site
502558003693	generic binding surface I; other site
502558003694	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
502558003695	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
502558003696	propionate/acetate kinase; Provisional; Region: PRK12379
502558003697	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
502558003698	nucleotide binding site/active site [active]
502558003699	HIT family signature motif; other site
502558003700	catalytic residue [active]
502558003701	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
502558003702	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
502558003703	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
502558003704	UDP-galactopyranose mutase; Region: GLF; pfam03275
502558003705	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
502558003706	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
502558003707	active site
502558003708	OPT oligopeptide transporter protein; Region: OPT; cl14607
502558003709	OPT oligopeptide transporter protein; Region: OPT; cl14607
502558003710	Type III pantothenate kinase; Region: Pan_kinase; cl17198
502558003711	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
502558003712	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
502558003713	Zn2+ binding site [ion binding]; other site
502558003714	Mg2+ binding site [ion binding]; other site
502558003715	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
502558003716	DNA primase, catalytic core; Region: dnaG; TIGR01391
502558003717	CHC2 zinc finger; Region: zf-CHC2; pfam01807
502558003718	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
502558003719	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
502558003720	active site
502558003721	metal binding site [ion binding]; metal-binding site
502558003722	interdomain interaction site; other site
502558003723	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
502558003724	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558003725	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558003726	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
502558003727	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
502558003728	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
502558003729	The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759
502558003730	putative [Fe4-S4] binding site [ion binding]; other site
502558003731	putative molybdopterin cofactor binding site [chemical binding]; other site
502558003732	The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781
502558003733	putative molybdopterin cofactor binding site; other site
502558003734	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
502558003735	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
502558003736	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558003737	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
502558003738	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
502558003739	putative DNA binding site [nucleotide binding]; other site
502558003740	dimerization interface [polypeptide binding]; other site
502558003741	Transcriptional regulators [Transcription]; Region: MarR; COG1846
502558003742	putative Zn2+ binding site [ion binding]; other site
502558003743	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
502558003744	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
502558003745	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
502558003746	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
502558003747	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
502558003748	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
502558003749	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
502558003750	Right handed beta helix region; Region: Beta_helix; pfam13229
502558003751	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
502558003752	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
502558003753	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
502558003754	active site
502558003755	catalytic residues [active]
502558003756	metal binding site [ion binding]; metal-binding site
502558003757	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
502558003758	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
502558003759	putative active site [active]
502558003760	substrate binding site [chemical binding]; other site
502558003761	putative cosubstrate binding site; other site
502558003762	catalytic site [active]
502558003763	Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911
502558003764	NusB family; Region: NusB; pfam01029
502558003765	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
502558003766	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558003767	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558003768	DNA binding residues [nucleotide binding]
502558003769	dimerization interface [polypeptide binding]; other site
502558003770	hypothetical protein; Validated; Region: PRK07121
502558003771	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558003772	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558003773	non-specific DNA binding site [nucleotide binding]; other site
502558003774	salt bridge; other site
502558003775	sequence-specific DNA binding site [nucleotide binding]; other site
502558003776	Cupin domain; Region: Cupin_2; pfam07883
502558003777	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558003778	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
502558003779	acyl-activating enzyme (AAE) consensus motif; other site
502558003780	AMP binding site [chemical binding]; other site
502558003781	active site
502558003782	CoA binding site [chemical binding]; other site
502558003783	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
502558003784	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
502558003785	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
502558003786	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
502558003787	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
502558003788	dimer interface [polypeptide binding]; other site
502558003789	PYR/PP interface [polypeptide binding]; other site
502558003790	TPP binding site [chemical binding]; other site
502558003791	substrate binding site [chemical binding]; other site
502558003792	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
502558003793	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
502558003794	TPP-binding site [chemical binding]; other site
502558003795	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
502558003796	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
502558003797	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558003798	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558003799	non-specific DNA binding site [nucleotide binding]; other site
502558003800	salt bridge; other site
502558003801	sequence-specific DNA binding site [nucleotide binding]; other site
502558003802	Cupin domain; Region: Cupin_2; pfam07883
502558003803	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558003804	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
502558003805	acyl-activating enzyme (AAE) consensus motif; other site
502558003806	AMP binding site [chemical binding]; other site
502558003807	active site
502558003808	CoA binding site [chemical binding]; other site
502558003809	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
502558003810	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
502558003811	active site
502558003812	catalytic tetrad [active]
502558003813	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
502558003814	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
502558003815	Catalytic domain of Protein Kinases; Region: PKc; cd00180
502558003816	active site
502558003817	ATP binding site [chemical binding]; other site
502558003818	substrate binding site [chemical binding]; other site
502558003819	activation loop (A-loop); other site
502558003820	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
502558003821	hypothetical protein; Provisional; Region: PRK03881
502558003822	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
502558003823	AMMECR1; Region: AMMECR1; pfam01871
502558003824	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
502558003825	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
502558003826	FeS/SAM binding site; other site
502558003827	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
502558003828	G1 box; other site
502558003829	GTPases - translation elongation factors [Translation, ribosomal structure and biogenesis]; Region: TufB; COG0050
502558003830	putative GEF interaction site [polypeptide binding]; other site
502558003831	GTP/Mg2+ binding site [chemical binding]; other site
502558003832	Switch I region; other site
502558003833	G2 box; other site
502558003834	G3 box; other site
502558003835	Switch II region; other site
502558003836	G4 box; other site
502558003837	G5 box; other site
502558003838	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
502558003839	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
502558003840	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
502558003841	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
502558003842	selenocysteine synthase; Provisional; Region: PRK04311
502558003843	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
502558003844	catalytic residue [active]
502558003845	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
502558003846	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
502558003847	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
502558003848	CPxP  motif; other site
502558003849	DsrE/DsrF-like family; Region: DrsE; pfam02635
502558003850	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
502558003851	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
502558003852	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
502558003853	catalytic residue [active]
502558003854	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
502558003855	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
502558003856	dimerization interface [polypeptide binding]; other site
502558003857	putative ATP binding site [chemical binding]; other site
502558003858	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
502558003859	DNA-binding site [nucleotide binding]; DNA binding site
502558003860	RNA-binding motif; other site
502558003861	RNA polymerase factor sigma C; Reviewed; Region: PRK09415
502558003862	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
502558003863	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
502558003864	DNA binding residues [nucleotide binding]
502558003865	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
502558003866	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
502558003867	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
502558003868	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
502558003869	NADH dehydrogenase; Region: NADHdh; cl00469
502558003870	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
502558003871	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
502558003872	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
502558003873	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
502558003874	NADH-plastoquinone oxidoreductase subunit; Provisional; Region: PRK08348
502558003875	4Fe-4S binding domain; Region: Fer4; cl02805
502558003876	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
502558003877	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
502558003878	VanW like protein; Region: VanW; pfam04294
502558003879	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
502558003880	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558003881	acyl-activating enzyme (AAE) consensus motif; other site
502558003882	AMP binding site [chemical binding]; other site
502558003883	active site
502558003884	CoA binding site [chemical binding]; other site
502558003885	ACT domain-containing protein [General function prediction only]; Region: COG4747
502558003886	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
502558003887	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
502558003888	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
502558003889	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
502558003890	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
502558003891	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
502558003892	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
502558003893	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
502558003894	phosphopeptide binding site; other site
502558003895	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
502558003896	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
502558003897	dimer interface [polypeptide binding]; other site
502558003898	PYR/PP interface [polypeptide binding]; other site
502558003899	TPP binding site [chemical binding]; other site
502558003900	substrate binding site [chemical binding]; other site
502558003901	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
502558003902	TPP-binding site; other site
502558003903	4Fe-4S binding domain; Region: Fer4; cl02805
502558003904	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
502558003905	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
502558003906	ACT domain-containing protein [General function prediction only]; Region: COG4747
502558003907	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
502558003908	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
502558003909	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
502558003910	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558003911	acyl-activating enzyme (AAE) consensus motif; other site
502558003912	AMP binding site [chemical binding]; other site
502558003913	active site
502558003914	CoA binding site [chemical binding]; other site
502558003915	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
502558003916	active site
502558003917	HIGH motif; other site
502558003918	nucleotide binding site [chemical binding]; other site
502558003919	active site
502558003920	KMSKS motif; other site
502558003921	VanZ like family; Region: VanZ; pfam04892
502558003922	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
502558003923	UbiA prenyltransferase family; Region: UbiA; pfam01040
502558003924	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
502558003925	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
502558003926	active site
502558003927	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
502558003928	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
502558003929	active site
502558003930	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
502558003931	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
502558003932	putative homodimer interface [polypeptide binding]; other site
502558003933	putative DNA binding site [nucleotide binding]; other site
502558003934	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
502558003935	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
502558003936	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
502558003937	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
502558003938	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
502558003939	DNA binding residues [nucleotide binding]
502558003940	putative dimer interface [polypeptide binding]; other site
502558003941	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
502558003942	trimer interface [polypeptide binding]; other site
502558003943	active site
502558003944	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
502558003945	ATP cone domain; Region: ATP-cone; pfam03477
502558003946	LexA repressor; Validated; Region: PRK00215
502558003947	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
502558003948	putative DNA binding site [nucleotide binding]; other site
502558003949	putative Zn2+ binding site [ion binding]; other site
502558003950	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
502558003951	Catalytic site [active]
502558003952	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
502558003953	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
502558003954	HflX GTPase family; Region: HflX; cd01878
502558003955	G1 box; other site
502558003956	GTP/Mg2+ binding site [chemical binding]; other site
502558003957	Switch I region; other site
502558003958	G2 box; other site
502558003959	G3 box; other site
502558003960	Switch II region; other site
502558003961	G4 box; other site
502558003962	G5 box; other site
502558003963	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
502558003964	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
502558003965	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
502558003966	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
502558003967	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
502558003968	FeS/SAM binding site; other site
502558003969	TRAM domain; Region: TRAM; pfam01938
502558003970	Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005
502558003971	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558003972	ATP binding site [chemical binding]; other site
502558003973	Mg2+ binding site [ion binding]; other site
502558003974	G-X-G motif; other site
502558003975	phosphodiesterase; Provisional; Region: PRK12704
502558003976	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
502558003977	Zn2+ binding site [ion binding]; other site
502558003978	Mg2+ binding site [ion binding]; other site
502558003979	RecX family; Region: RecX; cl00936
502558003980	recombinase A; Provisional; Region: recA; PRK09354
502558003981	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
502558003982	hexamer interface [polypeptide binding]; other site
502558003983	Walker A motif; other site
502558003984	ATP binding site [chemical binding]; other site
502558003985	Walker B motif; other site
502558003986	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
502558003987	Competence-damaged protein; Region: CinA; pfam02464
502558003988	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
502558003989	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
502558003990	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
502558003991	FeS/SAM binding site; other site
502558003992	TRAM domain; Region: TRAM; cl01282
502558003993	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
502558003994	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
502558003995	Helix-turn-helix domain; Region: HTH_25; pfam13413
502558003996	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
502558003997	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
502558003998	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
502558003999	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
502558004000	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
502558004001	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
502558004002	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
502558004003	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
502558004004	dihydrodipicolinate synthase; Region: dapA; TIGR00674
502558004005	dimer interface [polypeptide binding]; other site
502558004006	active site
502558004007	catalytic residue [active]
502558004008	dihydrodipicolinate reductase; Provisional; Region: PRK00048
502558004009	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
502558004010	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
502558004011	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
502558004012	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
502558004013	RNase E interface [polypeptide binding]; other site
502558004014	trimer interface [polypeptide binding]; other site
502558004015	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
502558004016	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
502558004017	RNase E interface [polypeptide binding]; other site
502558004018	trimer interface [polypeptide binding]; other site
502558004019	active site
502558004020	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
502558004021	putative nucleic acid binding region [nucleotide binding]; other site
502558004022	G-X-X-G motif; other site
502558004023	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
502558004024	RNA binding site [nucleotide binding]; other site
502558004025	domain interface; other site
502558004026	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
502558004027	16S/18S rRNA binding site [nucleotide binding]; other site
502558004028	S13e-L30e interaction site [polypeptide binding]; other site
502558004029	25S rRNA binding site [nucleotide binding]; other site
502558004030	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
502558004031	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
502558004032	dimer interface [polypeptide binding]; other site
502558004033	phosphorylation site [posttranslational modification]
502558004034	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558004035	ATP binding site [chemical binding]; other site
502558004036	Mg2+ binding site [ion binding]; other site
502558004037	G-X-G motif; other site
502558004038	TSCPD domain; Region: TSCPD; cl14834
502558004039	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
502558004040	Recombination protein O N terminal; Region: RecO_N; pfam11967
502558004041	Recombination protein O C terminal; Region: RecO_C; pfam02565
502558004042	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
502558004043	Double zinc ribbon; Region: DZR; pfam12773
502558004044	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
502558004045	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
502558004046	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
502558004047	GTPase Era; Reviewed; Region: era; PRK00089
502558004048	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
502558004049	G1 box; other site
502558004050	GTP/Mg2+ binding site [chemical binding]; other site
502558004051	Switch I region; other site
502558004052	G2 box; other site
502558004053	Switch II region; other site
502558004054	G3 box; other site
502558004055	G4 box; other site
502558004056	G5 box; other site
502558004057	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
502558004058	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
502558004059	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
502558004060	PhoH-like protein; Region: PhoH; pfam02562
502558004061	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
502558004062	putative active site [active]
502558004063	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
502558004064	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
502558004065	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
502558004066	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
502558004067	chaperone protein DnaJ; Provisional; Region: PRK14299
502558004068	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
502558004069	HSP70 interaction site [polypeptide binding]; other site
502558004070	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
502558004071	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
502558004072	Zn binding sites [ion binding]; other site
502558004073	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
502558004074	dimer interface [polypeptide binding]; other site
502558004075	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
502558004076	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
502558004077	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
502558004078	amidase catalytic site [active]
502558004079	Zn binding residues [ion binding]; other site
502558004080	substrate binding site [chemical binding]; other site
502558004081	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
502558004082	Double zinc ribbon; Region: DZR; pfam12773
502558004083	YARHG domain; Region: YARHG; pfam13308
502558004084	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
502558004085	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
502558004086	FeS/SAM binding site; other site
502558004087	HemN C-terminal domain; Region: HemN_C; pfam06969
502558004088	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
502558004089	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
502558004090	FMN binding site [chemical binding]; other site
502558004091	active site
502558004092	catalytic residues [active]
502558004093	substrate binding site [chemical binding]; other site
502558004094	GTP-binding protein LepA; Provisional; Region: PRK05433
502558004095	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
502558004096	G1 box; other site
502558004097	putative GEF interaction site [polypeptide binding]; other site
502558004098	GTP/Mg2+ binding site [chemical binding]; other site
502558004099	Switch I region; other site
502558004100	G2 box; other site
502558004101	G3 box; other site
502558004102	Switch II region; other site
502558004103	G4 box; other site
502558004104	G5 box; other site
502558004105	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
502558004106	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
502558004107	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
502558004108	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
502558004109	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
502558004110	DNA polymerase III, delta subunit; Region: holA; TIGR01128
502558004111	Competence protein; Region: Competence; pfam03772
502558004112	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
502558004113	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
502558004114	SLBB domain; Region: SLBB; pfam10531
502558004115	comEA protein; Region: comE; TIGR01259
502558004116	Helix-hairpin-helix motif; Region: HHH; pfam00633
502558004117	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
502558004118	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
502558004119	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
502558004120	Ligand Binding Site [chemical binding]; other site
502558004121	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
502558004122	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
502558004123	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
502558004124	catalytic site [active]
502558004125	G-X2-G-X-G-K; other site
502558004126	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
502558004127	active site
502558004128	dimer interface [polypeptide binding]; other site
502558004129	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
502558004130	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
502558004131	heterodimer interface [polypeptide binding]; other site
502558004132	active site
502558004133	FMN binding site [chemical binding]; other site
502558004134	homodimer interface [polypeptide binding]; other site
502558004135	substrate binding site [chemical binding]; other site
502558004136	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
502558004137	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
502558004138	FAD binding pocket [chemical binding]; other site
502558004139	FAD binding motif [chemical binding]; other site
502558004140	phosphate binding motif [ion binding]; other site
502558004141	beta-alpha-beta structure motif; other site
502558004142	NAD binding pocket [chemical binding]; other site
502558004143	Iron coordination center [ion binding]; other site
502558004144	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558004145	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558004146	non-specific DNA binding site [nucleotide binding]; other site
502558004147	salt bridge; other site
502558004148	sequence-specific DNA binding site [nucleotide binding]; other site
502558004149	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
502558004150	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
502558004151	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
502558004152	Predicted transcriptional regulators [Transcription]; Region: COG1695
502558004153	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
502558004154	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558004155	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558004156	non-specific DNA binding site [nucleotide binding]; other site
502558004157	salt bridge; other site
502558004158	sequence-specific DNA binding site [nucleotide binding]; other site
502558004159	CAAX protease self-immunity; Region: Abi; pfam02517
502558004160	LabA_like proteins; Region: LabA; cd10911
502558004161	Uncharacterized conserved protein [Function unknown]; Region: COG1432
502558004162	putative metal binding site [ion binding]; other site
502558004163	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
502558004164	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
502558004165	ATP-grasp domain; Region: ATP-grasp_4; cl17255
502558004166	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
502558004167	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
502558004168	ATP-grasp domain; Region: ATP-grasp_4; cl17255
502558004169	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
502558004170	IMP binding site; other site
502558004171	dimer interface [polypeptide binding]; other site
502558004172	interdomain contacts; other site
502558004173	partial ornithine binding site; other site
502558004174	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
502558004175	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
502558004176	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
502558004177	catalytic site [active]
502558004178	subunit interface [polypeptide binding]; other site
502558004179	dihydroorotase; Validated; Region: pyrC; PRK09357
502558004180	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
502558004181	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
502558004182	active site
502558004183	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
502558004184	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
502558004185	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
502558004186	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
502558004187	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
502558004188	active site
502558004189	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
502558004190	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
502558004191	substrate binding site [chemical binding]; other site
502558004192	oxyanion hole (OAH) forming residues; other site
502558004193	trimer interface [polypeptide binding]; other site
502558004194	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
502558004195	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
502558004196	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
502558004197	active site
502558004198	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558004199	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558004200	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
502558004201	dimerization interface [polypeptide binding]; other site
502558004202	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
502558004203	Flavoprotein; Region: Flavoprotein; pfam02441
502558004204	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
502558004205	ferrochelatase; Reviewed; Region: hemH; PRK00035
502558004206	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
502558004207	C-terminal domain interface [polypeptide binding]; other site
502558004208	active site
502558004209	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
502558004210	active site
502558004211	N-terminal domain interface [polypeptide binding]; other site
502558004212	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
502558004213	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
502558004214	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
502558004215	RNA binding surface [nucleotide binding]; other site
502558004216	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
502558004217	active site
502558004218	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
502558004219	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
502558004220	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
502558004221	active site
502558004222	HIGH motif; other site
502558004223	nucleotide binding site [chemical binding]; other site
502558004224	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
502558004225	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
502558004226	active site
502558004227	KMSKS motif; other site
502558004228	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
502558004229	tRNA binding surface [nucleotide binding]; other site
502558004230	anticodon binding site; other site
502558004231	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
502558004232	EDD domain protein, DegV family; Region: DegV; TIGR00762
502558004233	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
502558004234	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
502558004235	active site
502558004236	DNA polymerase IV; Validated; Region: PRK02406
502558004237	DNA binding site [nucleotide binding]
502558004238	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
502558004239	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
502558004240	pyridoxal 5'-phosphate binding site [chemical binding]; other site
502558004241	homodimer interface [polypeptide binding]; other site
502558004242	catalytic residue [active]
502558004243	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
502558004244	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
502558004245	metal-binding site [ion binding]
502558004246	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
502558004247	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
502558004248	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
502558004249	metal-binding site [ion binding]
502558004250	C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156
502558004251	putative homodimer interface [polypeptide binding]; other site
502558004252	putative homotetramer interface [polypeptide binding]; other site
502558004253	putative allosteric switch controlling residues; other site
502558004254	putative metal binding site [ion binding]; other site
502558004255	putative homodimer-homodimer interface [polypeptide binding]; other site
502558004256	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
502558004257	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
502558004258	Coenzyme A binding pocket [chemical binding]; other site
502558004259	YoaP-like; Region: YoaP; pfam14268
502558004260	EamA-like transporter family; Region: EamA; pfam00892
502558004261	EamA-like transporter family; Region: EamA; pfam00892
502558004262	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
502558004263	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
502558004264	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
502558004265	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
502558004266	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
502558004267	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
502558004268	dimerization interface [polypeptide binding]; other site
502558004269	putative DNA binding site [nucleotide binding]; other site
502558004270	putative Zn2+ binding site [ion binding]; other site
502558004271	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
502558004272	metal-binding site [ion binding]
502558004273	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
502558004274	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
502558004275	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
502558004276	monoglyceride lipase; Provisional; Region: PHA02857
502558004277	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
502558004278	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
502558004279	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
502558004280	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
502558004281	catalytic residue [active]
502558004282	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
502558004283	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
502558004284	GMP synthase, PP-ATPase domain/subunit [Nucleotide transport and metabolism]; Region: GuaA; COG0519
502558004285	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
502558004286	ATP Binding subdomain [chemical binding]; other site
502558004287	Ligand Binding sites [chemical binding]; other site
502558004288	Dimerization subdomain; other site
502558004289	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
502558004290	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
502558004291	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
502558004292	Methyltransferase domain; Region: Methyltransf_31; pfam13847
502558004293	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
502558004294	S-adenosylmethionine binding site [chemical binding]; other site
502558004295	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558004296	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558004297	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558004298	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558004299	non-specific DNA binding site [nucleotide binding]; other site
502558004300	salt bridge; other site
502558004301	sequence-specific DNA binding site [nucleotide binding]; other site
502558004302	integrase; Provisional; Region: int; PHA02601
502558004303	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
502558004304	Int/Topo IB signature motif; other site
502558004305	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
502558004306	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
502558004307	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
502558004308	P-loop; other site
502558004309	Magnesium ion binding site [ion binding]; other site
502558004310	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
502558004311	ParB-like nuclease domain; Region: ParBc; pfam02195
502558004312	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
502558004313	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
502558004314	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
502558004315	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
502558004316	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
502558004317	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
502558004318	active site
502558004319	catalytic site [active]
502558004320	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
502558004321	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
502558004322	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
502558004323	NlpC/P60 family; Region: NLPC_P60; pfam00877
502558004324	AAA-like domain; Region: AAA_10; pfam12846
502558004325	Domain of unknown function DUF87; Region: DUF87; pfam01935
502558004326	PrgI family protein; Region: PrgI; pfam12666
502558004327	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
502558004328	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
502558004329	Walker A motif; other site
502558004330	ATP binding site [chemical binding]; other site
502558004331	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
502558004332	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
502558004333	hypothetical protein; Validated; Region: PRK08116
502558004334	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558004335	Walker A motif; other site
502558004336	ATP binding site [chemical binding]; other site
502558004337	Walker B motif; other site
502558004338	Helix-turn-helix domain; Region: HTH_36; pfam13730
502558004339	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
502558004340	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
502558004341	DNA binding residues [nucleotide binding]
502558004342	Helix-turn-helix domain; Region: HTH_17; pfam12728
502558004343	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558004344	Walker A/P-loop; other site
502558004345	ATP binding site [chemical binding]; other site
502558004346	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
502558004347	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
502558004348	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
502558004349	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
502558004350	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
502558004351	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
502558004352	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
502558004353	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
502558004354	Walker A/P-loop; other site
502558004355	ATP binding site [chemical binding]; other site
502558004356	Q-loop/lid; other site
502558004357	ABC transporter signature motif; other site
502558004358	Walker B; other site
502558004359	D-loop; other site
502558004360	H-loop/switch region; other site
502558004361	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
502558004362	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
502558004363	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558004364	Walker A/P-loop; other site
502558004365	ATP binding site [chemical binding]; other site
502558004366	Q-loop/lid; other site
502558004367	ABC transporter signature motif; other site
502558004368	Walker B; other site
502558004369	D-loop; other site
502558004370	H-loop/switch region; other site
502558004371	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
502558004372	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
502558004373	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558004374	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
502558004375	Q-loop/lid; other site
502558004376	ABC transporter signature motif; other site
502558004377	Walker B; other site
502558004378	D-loop; other site
502558004379	H-loop/switch region; other site
502558004380	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
502558004381	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
502558004382	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
502558004383	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
502558004384	Amidohydrolase; Region: Amidohydro_4; pfam13147
502558004385	active site
502558004386	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
502558004387	Integrase core domain; Region: rve_2; pfam13333
502558004388	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
502558004389	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
502558004390	G1 box; other site
502558004391	GTP/Mg2+ binding site [chemical binding]; other site
502558004392	Switch I region; other site
502558004393	G2 box; other site
502558004394	Switch II region; other site
502558004395	G3 box; other site
502558004396	G4 box; other site
502558004397	G5 box; other site
502558004398	[FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956
502558004399	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
502558004400	FeS/SAM binding site; other site
502558004401	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
502558004402	[FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955
502558004403	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
502558004404	FeS/SAM binding site; other site
502558004405	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
502558004406	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
502558004407	ATP-NAD kinase; Region: NAD_kinase; pfam01513
502558004408	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
502558004409	catalytic loop [active]
502558004410	iron binding site [ion binding]; other site
502558004411	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929
502558004412	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
502558004413	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
502558004414	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
502558004415	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
502558004416	NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493
502558004417	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
502558004418	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
502558004419	oxidoreductase; Provisional; Region: PRK10015
502558004420	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
502558004421	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
502558004422	active site
502558004423	FMN binding site [chemical binding]; other site
502558004424	substrate binding site [chemical binding]; other site
502558004425	putative catalytic residue [active]
502558004426	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
502558004427	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
502558004428	classical (c) SDRs; Region: SDR_c; cd05233
502558004429	NAD(P) binding site [chemical binding]; other site
502558004430	active site
502558004431	hypothetical protein; Validated; Region: PRK07121
502558004432	L-aspartate oxidase; Provisional; Region: PRK06175
502558004433	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558004434	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
502558004435	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
502558004436	Ligand Binding Site [chemical binding]; other site
502558004437	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
502558004438	Electron transfer flavoprotein domain; Region: ETF; pfam01012
502558004439	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
502558004440	active site
502558004441	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558004442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
502558004443	active site
502558004444	phosphorylation site [posttranslational modification]
502558004445	intermolecular recognition site; other site
502558004446	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558004447	DNA binding residues [nucleotide binding]
502558004448	dimerization interface [polypeptide binding]; other site
502558004449	Integrase core domain; Region: rve_2; pfam13333
502558004450	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
502558004451	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
502558004452	Transposase; Region: HTH_Tnp_1; pfam01527
502558004453	putative transposase OrfB; Reviewed; Region: PHA02517
502558004454	HTH-like domain; Region: HTH_21; pfam13276
502558004455	Integrase core domain; Region: rve; pfam00665
502558004456	Integrase core domain; Region: rve_3; pfam13683
502558004457	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
502558004458	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
502558004459	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
502558004460	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
502558004461	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
502558004462	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
502558004463	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
502558004464	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
502558004465	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
502558004466	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
502558004467	G1 box; other site
502558004468	GTP/Mg2+ binding site [chemical binding]; other site
502558004469	Switch I region; other site
502558004470	G2 box; other site
502558004471	G3 box; other site
502558004472	Switch II region; other site
502558004473	G4 box; other site
502558004474	G5 box; other site
502558004475	Nucleoside recognition; Region: Gate; pfam07670
502558004476	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
502558004477	FeoA domain; Region: FeoA; pfam04023
502558004478	Helix-turn-helix domain; Region: HTH_18; pfam12833
502558004479	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
502558004480	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558004481	Walker A/P-loop; other site
502558004482	ATP binding site [chemical binding]; other site
502558004483	Q-loop/lid; other site
502558004484	ABC transporter signature motif; other site
502558004485	Walker B; other site
502558004486	D-loop; other site
502558004487	H-loop/switch region; other site
502558004488	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
502558004489	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
502558004490	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558004491	Walker A/P-loop; other site
502558004492	ATP binding site [chemical binding]; other site
502558004493	Q-loop/lid; other site
502558004494	ABC transporter signature motif; other site
502558004495	Walker B; other site
502558004496	D-loop; other site
502558004497	H-loop/switch region; other site
502558004498	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
502558004499	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
502558004500	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
502558004501	Walker A/P-loop; other site
502558004502	ATP binding site [chemical binding]; other site
502558004503	Q-loop/lid; other site
502558004504	ABC transporter signature motif; other site
502558004505	Walker B; other site
502558004506	D-loop; other site
502558004507	H-loop/switch region; other site
502558004508	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558004509	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
502558004510	Walker A/P-loop; other site
502558004511	ATP binding site [chemical binding]; other site
502558004512	Q-loop/lid; other site
502558004513	ABC transporter signature motif; other site
502558004514	Walker B; other site
502558004515	D-loop; other site
502558004516	H-loop/switch region; other site
502558004517	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
502558004518	Helix-turn-helix domain; Region: HTH_18; pfam12833
502558004519	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
502558004520	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
502558004521	active site
502558004522	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
502558004523	AAA domain; Region: AAA_23; pfam13476
502558004524	Walker A/P-loop; other site
502558004525	ATP binding site [chemical binding]; other site
502558004526	AAA domain; Region: AAA_13; pfam13166
502558004527	Protein of unknown function DUF86; Region: DUF86; cl01031
502558004528	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558004529	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558004530	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
502558004531	Fic family protein [Function unknown]; Region: COG3177
502558004532	Fic/DOC family; Region: Fic; pfam02661
502558004533	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
502558004534	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
502558004535	active site
502558004536	catalytic residues [active]
502558004537	hypothetical protein; Validated; Region: PRK07121
502558004538	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558004539	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558004540	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558004541	DNA binding residues [nucleotide binding]
502558004542	dimerization interface [polypeptide binding]; other site
502558004543	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
502558004544	Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393
502558004545	ArsC family; Region: ArsC; pfam03960
502558004546	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
502558004547	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
502558004548	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
502558004549	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
502558004550	RNA binding site [nucleotide binding]; other site
502558004551	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
502558004552	homotrimer interaction site [polypeptide binding]; other site
502558004553	putative active site [active]
502558004554	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
502558004555	homotrimer interaction site [polypeptide binding]; other site
502558004556	putative active site [active]
502558004557	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
502558004558	homotrimer interaction site [polypeptide binding]; other site
502558004559	putative active site [active]
502558004560	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
502558004561	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
502558004562	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
502558004563	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
502558004564	ligand binding site [chemical binding]; other site
502558004565	homodimer interface [polypeptide binding]; other site
502558004566	NAD(P) binding site [chemical binding]; other site
502558004567	trimer interface B [polypeptide binding]; other site
502558004568	trimer interface A [polypeptide binding]; other site
502558004569	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
502558004570	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
502558004571	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558004572	Walker A/P-loop; other site
502558004573	ATP binding site [chemical binding]; other site
502558004574	Q-loop/lid; other site
502558004575	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
502558004576	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558004577	ABC transporter signature motif; other site
502558004578	Walker B; other site
502558004579	D-loop; other site
502558004580	H-loop/switch region; other site
502558004581	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558004582	Walker A/P-loop; other site
502558004583	ATP binding site [chemical binding]; other site
502558004584	Q-loop/lid; other site
502558004585	ABC transporter signature motif; other site
502558004586	Walker B; other site
502558004587	D-loop; other site
502558004588	H-loop/switch region; other site
502558004589	Predicted membrane protein [Function unknown]; Region: COG1511
502558004590	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
502558004591	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
502558004592	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
502558004593	Predicted membrane protein [Function unknown]; Region: COG1511
502558004594	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
502558004595	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
502558004596	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
502558004597	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
502558004598	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
502558004599	iron-sulfur cluster [ion binding]; other site
502558004600	[2Fe-2S] cluster binding site [ion binding]; other site
502558004601	DNA polymerase IV; Reviewed; Region: PRK03103
502558004602	Y-family of DNA polymerases; Region: PolY; cl12025
502558004603	active site
502558004604	DNA binding site [nucleotide binding]
502558004605	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558004606	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558004607	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
502558004608	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
502558004609	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
502558004610	Predicted transcriptional regulators [Transcription]; Region: COG1725
502558004611	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
502558004612	DNA-binding site [nucleotide binding]; DNA binding site
502558004613	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
502558004614	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
502558004615	isocitrate dehydrogenase; Validated; Region: PRK08299
502558004616	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
502558004617	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
502558004618	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558004619	Walker A/P-loop; other site
502558004620	ATP binding site [chemical binding]; other site
502558004621	Q-loop/lid; other site
502558004622	ABC transporter signature motif; other site
502558004623	Walker B; other site
502558004624	D-loop; other site
502558004625	H-loop/switch region; other site
502558004626	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
502558004627	Mechanosensitive ion channel; Region: MS_channel; pfam00924
502558004628	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
502558004629	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
502558004630	substrate binding pocket [chemical binding]; other site
502558004631	membrane-bound complex binding site; other site
502558004632	hinge residues; other site
502558004633	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
502558004634	ATP binding site [chemical binding]; other site
502558004635	putative Mg++ binding site [ion binding]; other site
502558004636	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
502558004637	nucleotide binding region [chemical binding]; other site
502558004638	ATP-binding site [chemical binding]; other site
502558004639	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
502558004640	Cupin domain; Region: Cupin_2; cl17218
502558004641	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558004642	Major Facilitator Superfamily; Region: MFS_1; pfam07690
502558004643	putative substrate translocation pore; other site
502558004644	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
502558004645	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
502558004646	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
502558004647	ABC transporter; Region: ABC_tran_2; pfam12848
502558004648	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
502558004649	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558004650	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558004651	DNA binding residues [nucleotide binding]
502558004652	dimerization interface [polypeptide binding]; other site
502558004653	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
502558004654	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
502558004655	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
502558004656	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
502558004657	Ligand binding site; other site
502558004658	Putative Catalytic site; other site
502558004659	DXD motif; other site
502558004660	flagellin modification protein A; Provisional; Region: PRK09186
502558004661	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
502558004662	NAD(P) binding site [chemical binding]; other site
502558004663	active site
502558004664	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
502558004665	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
502558004666	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
502558004667	PYR/PP interface [polypeptide binding]; other site
502558004668	dimer interface [polypeptide binding]; other site
502558004669	TPP binding site [chemical binding]; other site
502558004670	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
502558004671	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
502558004672	TPP-binding site [chemical binding]; other site
502558004673	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
502558004674	NeuB family; Region: NeuB; pfam03102
502558004675	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
502558004676	NeuB binding interface [polypeptide binding]; other site
502558004677	putative substrate binding site [chemical binding]; other site
502558004678	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
502558004679	ligand binding site; other site
502558004680	tetramer interface; other site
502558004681	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
502558004682	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
502558004683	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
502558004684	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
502558004685	NAD(P) binding site [chemical binding]; other site
502558004686	active site
502558004687	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
502558004688	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
502558004689	inhibitor-cofactor binding pocket; inhibition site
502558004690	pyridoxal 5'-phosphate binding site [chemical binding]; other site
502558004691	catalytic residue [active]
502558004692	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
502558004693	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
502558004694	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
502558004695	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
502558004696	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
502558004697	NAD(P) binding site [chemical binding]; other site
502558004698	active site
502558004699	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
502558004700	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
502558004701	substrate binding site; other site
502558004702	Transcriptional regulator [Transcription]; Region: LytR; COG1316
502558004703	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
502558004704	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
502558004705	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
502558004706	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
502558004707	Coenzyme A binding pocket [chemical binding]; other site
502558004708	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
502558004709	EamA-like transporter family; Region: EamA; pfam00892
502558004710	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
502558004711	EamA-like transporter family; Region: EamA; pfam00892
502558004712	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
502558004713	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
502558004714	Coenzyme A binding pocket [chemical binding]; other site
502558004715	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
502558004716	EamA-like transporter family; Region: EamA; pfam00892
502558004717	EamA-like transporter family; Region: EamA; pfam00892
502558004718	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
502558004719	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
502558004720	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
502558004721	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
502558004722	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
502558004723	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
502558004724	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
502558004725	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
502558004726	Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119
502558004727	FtsX-like permease family; Region: FtsX; pfam02687
502558004728	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
502558004729	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
502558004730	Walker A/P-loop; other site
502558004731	ATP binding site [chemical binding]; other site
502558004732	Q-loop/lid; other site
502558004733	ABC transporter signature motif; other site
502558004734	Walker B; other site
502558004735	D-loop; other site
502558004736	H-loop/switch region; other site
502558004737	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
502558004738	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
502558004739	phosphorylation site [posttranslational modification]
502558004740	dimer interface [polypeptide binding]; other site
502558004741	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558004742	ATP binding site [chemical binding]; other site
502558004743	Mg2+ binding site [ion binding]; other site
502558004744	G-X-G motif; other site
502558004745	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
502558004746	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558004747	active site
502558004748	phosphorylation site [posttranslational modification]
502558004749	intermolecular recognition site; other site
502558004750	dimerization interface [polypeptide binding]; other site
502558004751	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
502558004752	DNA binding site [nucleotide binding]
502558004753	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
502558004754	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
502558004755	active site
502558004756	DNA binding site [nucleotide binding]
502558004757	Int/Topo IB signature motif; other site
502558004758	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
502558004759	Glucose inhibited division protein A; Region: GIDA; pfam01134
502558004760	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
502558004761	DNA protecting protein DprA; Region: dprA; TIGR00732
502558004762	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
502558004763	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
502558004764	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558004765	Walker A motif; other site
502558004766	ATP binding site [chemical binding]; other site
502558004767	Walker B motif; other site
502558004768	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
502558004769	hypothetical protein; Reviewed; Region: PRK12497
502558004770	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
502558004771	RNA/DNA hybrid binding site [nucleotide binding]; other site
502558004772	active site
502558004773	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
502558004774	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
502558004775	AzlC protein; Region: AzlC; pfam03591
502558004776	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
502558004777	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
502558004778	active site
502558004779	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
502558004780	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
502558004781	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
502558004782	Zn2+ binding site [ion binding]; other site
502558004783	Mg2+ binding site [ion binding]; other site
502558004784	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
502558004785	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
502558004786	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
502558004787	Transcriptional regulators [Transcription]; Region: MarR; COG1846
502558004788	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
502558004789	hypothetical protein; Validated; Region: PRK07121
502558004790	FMN-binding domain; Region: FMN_bind; cl01081
502558004791	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558004792	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558004793	pyruvate phosphate dikinase; Provisional; Region: PRK09279
502558004794	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
502558004795	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
502558004796	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
502558004797	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
502558004798	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
502558004799	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
502558004800	dimer interface [polypeptide binding]; other site
502558004801	motif 1; other site
502558004802	active site
502558004803	motif 2; other site
502558004804	motif 3; other site
502558004805	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
502558004806	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
502558004807	Catalytic site [active]
502558004808	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
502558004809	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
502558004810	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
502558004811	KH domain; Region: KH_4; pfam13083
502558004812	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
502558004813	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
502558004814	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558004815	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558004816	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558004817	DNA binding residues [nucleotide binding]
502558004818	dimerization interface [polypeptide binding]; other site
502558004819	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
502558004820	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
502558004821	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
502558004822	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
502558004823	Walker A/P-loop; other site
502558004824	ATP binding site [chemical binding]; other site
502558004825	Q-loop/lid; other site
502558004826	ABC transporter signature motif; other site
502558004827	Walker B; other site
502558004828	D-loop; other site
502558004829	H-loop/switch region; other site
502558004830	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
502558004831	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
502558004832	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
502558004833	active site
502558004834	catalytic residues [active]
502558004835	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
502558004836	catalytic residues [active]
502558004837	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
502558004838	signal recognition particle protein; Provisional; Region: PRK10867
502558004839	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
502558004840	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
502558004841	P loop; other site
502558004842	GTP binding site [chemical binding]; other site
502558004843	Signal peptide binding domain; Region: SRP_SPB; pfam02978
502558004844	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558004845	non-specific DNA binding site [nucleotide binding]; other site
502558004846	salt bridge; other site
502558004847	sequence-specific DNA binding site [nucleotide binding]; other site
502558004848	Domain of unknown function (DUF955); Region: DUF955; pfam06114
502558004849	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
502558004850	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
502558004851	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
502558004852	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
502558004853	P loop; other site
502558004854	GTP binding site [chemical binding]; other site
502558004855	glucose-1-dehydrogenase; Provisional; Region: PRK08936
502558004856	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
502558004857	NAD binding site [chemical binding]; other site
502558004858	homodimer interface [polypeptide binding]; other site
502558004859	active site
502558004860	Predicted membrane protein [Function unknown]; Region: COG2364
502558004861	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
502558004862	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
502558004863	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
502558004864	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
502558004865	4Fe-4S binding domain; Region: Fer4; cl02805
502558004866	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
502558004867	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558004868	molybdopterin cofactor binding site; other site
502558004869	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
502558004870	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558004871	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558004872	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
502558004873	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
502558004874	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
502558004875	Walker A/P-loop; other site
502558004876	ATP binding site [chemical binding]; other site
502558004877	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
502558004878	ABC transporter signature motif; other site
502558004879	Walker B; other site
502558004880	D-loop; other site
502558004881	H-loop/switch region; other site
502558004882	ribonuclease III; Reviewed; Region: rnc; PRK00102
502558004883	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
502558004884	dimerization interface [polypeptide binding]; other site
502558004885	active site
502558004886	metal binding site [ion binding]; metal-binding site
502558004887	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
502558004888	dsRNA binding site [nucleotide binding]; other site
502558004889	putative phosphate acyltransferase; Provisional; Region: PRK05331
502558004890	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
502558004891	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
502558004892	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
502558004893	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
502558004894	Walker A/P-loop; other site
502558004895	ATP binding site [chemical binding]; other site
502558004896	Q-loop/lid; other site
502558004897	ABC transporter signature motif; other site
502558004898	Walker B; other site
502558004899	D-loop; other site
502558004900	H-loop/switch region; other site
502558004901	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
502558004902	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
502558004903	Cl- selectivity filter; other site
502558004904	Cl- binding residues [ion binding]; other site
502558004905	pore gating glutamate residue; other site
502558004906	dimer interface [polypeptide binding]; other site
502558004907	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
502558004908	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
502558004909	Walker A/P-loop; other site
502558004910	ATP binding site [chemical binding]; other site
502558004911	Q-loop/lid; other site
502558004912	ABC transporter signature motif; other site
502558004913	Walker B; other site
502558004914	D-loop; other site
502558004915	H-loop/switch region; other site
502558004916	Predicted transcriptional regulators [Transcription]; Region: COG1725
502558004917	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
502558004918	DNA-binding site [nucleotide binding]; DNA binding site
502558004919	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
502558004920	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
502558004921	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
502558004922	active site
502558004923	(T/H)XGH motif; other site
502558004924	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
502558004925	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
502558004926	S-adenosylmethionine binding site [chemical binding]; other site
502558004927	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
502558004928	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
502558004929	generic binding surface II; other site
502558004930	ssDNA binding site; other site
502558004931	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
502558004932	ATP binding site [chemical binding]; other site
502558004933	putative Mg++ binding site [ion binding]; other site
502558004934	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
502558004935	nucleotide binding region [chemical binding]; other site
502558004936	ATP-binding site [chemical binding]; other site
502558004937	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
502558004938	DAK2 domain; Region: Dak2; pfam02734
502558004939	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
502558004940	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
502558004941	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
502558004942	Putative zinc ribbon domain; Region: DUF164; pfam02591
502558004943	Uncharacterized conserved protein [Function unknown]; Region: COG0327
502558004944	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
502558004945	histidinol-phosphatase; Provisional; Region: PRK07328
502558004946	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
502558004947	active site
502558004948	dimer interface [polypeptide binding]; other site
502558004949	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
502558004950	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
502558004951	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
502558004952	catalytic residue [active]
502558004953	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
502558004954	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
502558004955	substrate binding site [chemical binding]; other site
502558004956	hexamer interface [polypeptide binding]; other site
502558004957	metal binding site [ion binding]; metal-binding site
502558004958	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
502558004959	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
502558004960	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
502558004961	DNA binding site [nucleotide binding]
502558004962	active site
502558004963	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
502558004964	RDD family; Region: RDD; pfam06271
502558004965	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
502558004966	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
502558004967	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
502558004968	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
502558004969	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
502558004970	GTP-binding protein Der; Reviewed; Region: PRK00093
502558004971	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
502558004972	G1 box; other site
502558004973	GTP/Mg2+ binding site [chemical binding]; other site
502558004974	Switch I region; other site
502558004975	G2 box; other site
502558004976	Switch II region; other site
502558004977	G3 box; other site
502558004978	G4 box; other site
502558004979	G5 box; other site
502558004980	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
502558004981	G1 box; other site
502558004982	GTP/Mg2+ binding site [chemical binding]; other site
502558004983	Switch I region; other site
502558004984	G2 box; other site
502558004985	G3 box; other site
502558004986	Switch II region; other site
502558004987	G4 box; other site
502558004988	G5 box; other site
502558004989	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
502558004990	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
502558004991	Protein of unknown function (DUF512); Region: DUF512; pfam04459
502558004992	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
502558004993	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
502558004994	Peptidase family M23; Region: Peptidase_M23; pfam01551
502558004995	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
502558004996	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
502558004997	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
502558004998	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
502558004999	putative acyl-acceptor binding pocket; other site
502558005000	cytidylate kinase; Provisional; Region: cmk; PRK00023
502558005001	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
502558005002	CMP-binding site; other site
502558005003	The sites determining sugar specificity; other site
502558005004	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
502558005005	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
502558005006	hinge; other site
502558005007	active site
502558005008	prephenate dehydrogenase; Validated; Region: PRK06545
502558005009	prephenate dehydrogenase; Validated; Region: PRK08507
502558005010	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
502558005011	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
502558005012	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
502558005013	RNA binding surface [nucleotide binding]; other site
502558005014	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
502558005015	active site
502558005016	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
502558005017	ScpA/B protein; Region: ScpA_ScpB; cl00598
502558005018	Peptidase family M50; Region: Peptidase_M50; pfam02163
502558005019	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
502558005020	active site
502558005021	putative substrate binding region [chemical binding]; other site
502558005022	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
502558005023	homodimer interface [polypeptide binding]; other site
502558005024	substrate-cofactor binding pocket; other site
502558005025	pyridoxal 5'-phosphate binding site [chemical binding]; other site
502558005026	catalytic residue [active]
502558005027	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
502558005028	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
502558005029	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
502558005030	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
502558005031	ABC transporter; Region: ABC_tran_2; pfam12848
502558005032	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
502558005033	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
502558005034	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
502558005035	DNA binding residues [nucleotide binding]
502558005036	putative dimer interface [polypeptide binding]; other site
502558005037	carbamate kinase; Reviewed; Region: PRK12686
502558005038	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
502558005039	putative substrate binding site [chemical binding]; other site
502558005040	nucleotide binding site [chemical binding]; other site
502558005041	nucleotide binding site [chemical binding]; other site
502558005042	homodimer interface [polypeptide binding]; other site
502558005043	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
502558005044	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
502558005045	transmembrane helices; other site
502558005046	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
502558005047	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
502558005048	putrescine carbamoyltransferase; Provisional; Region: PRK02255
502558005049	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
502558005050	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
502558005051	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558005052	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558005053	DNA binding residues [nucleotide binding]
502558005054	dimerization interface [polypeptide binding]; other site
502558005055	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
502558005056	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
502558005057	active site
502558005058	catalytic tetrad [active]
502558005059	ferredoxin-like protein FixX; Provisional; Region: PRK15449
502558005060	oxidoreductase; Provisional; Region: PRK10015
502558005061	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
502558005062	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
502558005063	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
502558005064	Ligand binding site [chemical binding]; other site
502558005065	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
502558005066	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
502558005067	Ligand Binding Site [chemical binding]; other site
502558005068	Electron transfer flavoprotein domain; Region: ETF; pfam01012
502558005069	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
502558005070	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
502558005071	transmembrane helices; other site
502558005072	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
502558005073	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558005074	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558005075	acyl-activating enzyme (AAE) consensus motif; other site
502558005076	acyl-activating enzyme (AAE) consensus motif; other site
502558005077	AMP binding site [chemical binding]; other site
502558005078	active site
502558005079	CoA binding site [chemical binding]; other site
502558005080	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
502558005081	CoA-transferase family III; Region: CoA_transf_3; pfam02515
502558005082	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
502558005083	CoenzymeA binding site [chemical binding]; other site
502558005084	subunit interaction site [polypeptide binding]; other site
502558005085	PHB binding site; other site
502558005086	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
502558005087	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
502558005088	active site
502558005089	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558005090	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558005091	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
502558005092	enoyl-CoA hydratase; Provisional; Region: PRK06494
502558005093	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
502558005094	substrate binding site [chemical binding]; other site
502558005095	oxyanion hole (OAH) forming residues; other site
502558005096	trimer interface [polypeptide binding]; other site
502558005097	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
502558005098	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558005099	putative substrate translocation pore; other site
502558005100	enoyl-CoA hydratase; Region: PLN02864
502558005101	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
502558005102	active site 2 [active]
502558005103	active site 1 [active]
502558005104	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
502558005105	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558005106	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
502558005107	acyl-activating enzyme (AAE) consensus motif; other site
502558005108	putative AMP binding site [chemical binding]; other site
502558005109	putative active site [active]
502558005110	putative CoA binding site [chemical binding]; other site
502558005111	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
502558005112	CoA-transferase family III; Region: CoA_transf_3; pfam02515
502558005113	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
502558005114	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
502558005115	active site
502558005116	acetyl esterase; Provisional; Region: PRK10162
502558005117	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
502558005118	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558005119	putative substrate translocation pore; other site
502558005120	Major Facilitator Superfamily; Region: MFS_1; pfam07690
502558005121	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558005122	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558005123	DNA binding residues [nucleotide binding]
502558005124	dimerization interface [polypeptide binding]; other site
502558005125	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
502558005126	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
502558005127	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
502558005128	active site
502558005129	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
502558005130	CoA-transferase family III; Region: CoA_transf_3; pfam02515
502558005131	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
502558005132	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
502558005133	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
502558005134	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
502558005135	substrate binding site [chemical binding]; other site
502558005136	oxyanion hole (OAH) forming residues; other site
502558005137	trimer interface [polypeptide binding]; other site
502558005138	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558005139	acyl-activating enzyme (AAE) consensus motif; other site
502558005140	active site
502558005141	AMP binding site [chemical binding]; other site
502558005142	CoA binding site [chemical binding]; other site
502558005143	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558005144	CoA binding site [chemical binding]; other site
502558005145	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
502558005146	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
502558005147	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
502558005148	active site
502558005149	FMN binding site [chemical binding]; other site
502558005150	substrate binding site [chemical binding]; other site
502558005151	putative catalytic residue [active]
502558005152	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
502558005153	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
502558005154	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558005155	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558005156	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558005157	metal binding site [ion binding]; metal-binding site
502558005158	active site
502558005159	I-site; other site
502558005160	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
502558005161	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
502558005162	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
502558005163	putative active site [active]
502558005164	heme pocket [chemical binding]; other site
502558005165	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
502558005166	putative active site [active]
502558005167	heme pocket [chemical binding]; other site
502558005168	PAS domain; Region: PAS_9; pfam13426
502558005169	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558005170	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558005171	non-specific DNA binding site [nucleotide binding]; other site
502558005172	salt bridge; other site
502558005173	sequence-specific DNA binding site [nucleotide binding]; other site
502558005174	Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117
502558005175	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
502558005176	NAD(P) binding site [chemical binding]; other site
502558005177	catalytic residues [active]
502558005178	2-isopropylmalate synthase; Validated; Region: PRK00915
502558005179	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
502558005180	active site
502558005181	catalytic residues [active]
502558005182	metal binding site [ion binding]; metal-binding site
502558005183	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
502558005184	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
502558005185	4Fe-4S binding domain; Region: Fer4; cl02805
502558005186	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558005187	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
502558005188	molybdopterin cofactor binding site; other site
502558005189	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
502558005190	molybdopterin cofactor binding site; other site
502558005191	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558005192	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558005193	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
502558005194	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
502558005195	ligand binding site [chemical binding]; other site
502558005196	NAD binding site [chemical binding]; other site
502558005197	dimerization interface [polypeptide binding]; other site
502558005198	catalytic site [active]
502558005199	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
502558005200	putative L-serine binding site [chemical binding]; other site
502558005201	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
502558005202	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
502558005203	NAD(P) binding site [chemical binding]; other site
502558005204	active site
502558005205	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
502558005206	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
502558005207	putative active site [active]
502558005208	putative FMN binding site [chemical binding]; other site
502558005209	putative substrate binding site [chemical binding]; other site
502558005210	putative catalytic residue [active]
502558005211	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558005212	Major Facilitator Superfamily; Region: MFS_1; pfam07690
502558005213	putative substrate translocation pore; other site
502558005214	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558005215	Major Facilitator Superfamily; Region: MFS_1; pfam07690
502558005216	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558005217	putative substrate translocation pore; other site
502558005218	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
502558005219	Ligand Binding Site [chemical binding]; other site
502558005220	Electron transfer flavoprotein domain; Region: ETF; pfam01012
502558005221	oxidoreductase; Provisional; Region: PRK10015
502558005222	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
502558005223	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
502558005224	Ligand Binding Site [chemical binding]; other site
502558005225	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
502558005226	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
502558005227	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
502558005228	active site
502558005229	FMN binding site [chemical binding]; other site
502558005230	substrate binding site [chemical binding]; other site
502558005231	putative catalytic residue [active]
502558005232	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
502558005233	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558005234	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558005235	ketol-acid reductoisomerase; Provisional; Region: PRK05479
502558005236	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
502558005237	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
502558005238	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
502558005239	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
502558005240	putative valine binding site [chemical binding]; other site
502558005241	dimer interface [polypeptide binding]; other site
502558005242	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
502558005243	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
502558005244	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
502558005245	PYR/PP interface [polypeptide binding]; other site
502558005246	dimer interface [polypeptide binding]; other site
502558005247	TPP binding site [chemical binding]; other site
502558005248	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
502558005249	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
502558005250	TPP-binding site [chemical binding]; other site
502558005251	dimer interface [polypeptide binding]; other site
502558005252	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
502558005253	6-phosphogluconate dehydratase; Region: edd; TIGR01196
502558005254	Right handed beta helix region; Region: Beta_helix; pfam13229
502558005255	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
502558005256	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
502558005257	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
502558005258	putative active site [active]
502558005259	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
502558005260	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
502558005261	trimer interface [polypeptide binding]; other site
502558005262	putative metal binding site [ion binding]; other site
502558005263	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
502558005264	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
502558005265	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
502558005266	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
502558005267	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
502558005268	Soluble P-type ATPase [General function prediction only]; Region: COG4087
502558005269	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
502558005270	purine nucleoside phosphorylase; Provisional; Region: PRK08202
502558005271	HemK family putative methylases; Region: hemK_fam; TIGR00536
502558005272	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
502558005273	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
502558005274	S-adenosylmethionine binding site [chemical binding]; other site
502558005275	Predicted ATPase [General function prediction only]; Region: COG4637
502558005276	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558005277	Walker A/P-loop; other site
502558005278	ATP binding site [chemical binding]; other site
502558005279	peptide chain release factor 1; Validated; Region: prfA; PRK00591
502558005280	PCRF domain; Region: PCRF; pfam03462
502558005281	RF-1 domain; Region: RF-1; pfam00472
502558005282	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558005283	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558005284	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
502558005285	dimerization interface [polypeptide binding]; other site
502558005286	hypothetical protein; Validated; Region: PRK07121
502558005287	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
502558005288	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
502558005289	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
502558005290	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
502558005291	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
502558005292	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
502558005293	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
502558005294	DNA binding residues [nucleotide binding]
502558005295	dimer interface [polypeptide binding]; other site
502558005296	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558005297	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558005298	DNA binding residues [nucleotide binding]
502558005299	dimerization interface [polypeptide binding]; other site
502558005300	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
502558005301	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558005302	molybdopterin cofactor binding site; other site
502558005303	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
502558005304	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
502558005305	4Fe-4S binding domain; Region: Fer4; pfam00037
502558005306	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
502558005307	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
502558005308	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558005309	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558005310	metal binding site [ion binding]; metal-binding site
502558005311	active site
502558005312	I-site; other site
502558005313	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
502558005314	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
502558005315	catalytic residues [active]
502558005316	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
502558005317	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
502558005318	active site
502558005319	nucleophile elbow; other site
502558005320	Ion transport protein; Region: Ion_trans; pfam00520
502558005321	Ion channel; Region: Ion_trans_2; pfam07885
502558005322	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
502558005323	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
502558005324	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
502558005325	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
502558005326	Na binding site [ion binding]; other site
502558005327	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558005328	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558005329	DNA binding residues [nucleotide binding]
502558005330	dimerization interface [polypeptide binding]; other site
502558005331	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
502558005332	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
502558005333	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
502558005334	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
502558005335	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
502558005336	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
502558005337	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
502558005338	active site
502558005339	dimer interface [polypeptide binding]; other site
502558005340	motif 1; other site
502558005341	motif 2; other site
502558005342	motif 3; other site
502558005343	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
502558005344	anticodon binding site; other site
502558005345	Double zinc ribbon; Region: DZR; pfam12773
502558005346	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558005347	non-specific DNA binding site [nucleotide binding]; other site
502558005348	salt bridge; other site
502558005349	sequence-specific DNA binding site [nucleotide binding]; other site
502558005350	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
502558005351	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
502558005352	active site
502558005353	HIGH motif; other site
502558005354	nucleotide binding site [chemical binding]; other site
502558005355	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
502558005356	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
502558005357	active site
502558005358	KMSKS motif; other site
502558005359	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
502558005360	tRNA binding surface [nucleotide binding]; other site
502558005361	anticodon binding site; other site
502558005362	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
502558005363	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
502558005364	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
502558005365	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558005366	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
502558005367	Walker A motif; other site
502558005368	ATP binding site [chemical binding]; other site
502558005369	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
502558005370	Clp protease; Region: CLP_protease; pfam00574
502558005371	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
502558005372	oligomer interface [polypeptide binding]; other site
502558005373	active site residues [active]
502558005374	trigger factor; Provisional; Region: tig; PRK01490
502558005375	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
502558005376	serine/threonine transporter SstT; Provisional; Region: PRK13628
502558005377	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
502558005378	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
502558005379	Uncharacterized conserved protein [Function unknown]; Region: COG1432
502558005380	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
502558005381	putative metal binding site [ion binding]; other site
502558005382	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
502558005383	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
502558005384	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
502558005385	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
502558005386	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
502558005387	DNA binding residues [nucleotide binding]
502558005388	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
502558005389	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
502558005390	Walker A/P-loop; other site
502558005391	ATP binding site [chemical binding]; other site
502558005392	Q-loop/lid; other site
502558005393	ABC transporter signature motif; other site
502558005394	Walker B; other site
502558005395	D-loop; other site
502558005396	H-loop/switch region; other site
502558005397	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
502558005398	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558005399	active site
502558005400	phosphorylation site [posttranslational modification]
502558005401	intermolecular recognition site; other site
502558005402	dimerization interface [polypeptide binding]; other site
502558005403	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
502558005404	DNA binding site [nucleotide binding]
502558005405	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
502558005406	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
502558005407	dimer interface [polypeptide binding]; other site
502558005408	phosphorylation site [posttranslational modification]
502558005409	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558005410	ATP binding site [chemical binding]; other site
502558005411	Mg2+ binding site [ion binding]; other site
502558005412	G-X-G motif; other site
502558005413	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
502558005414	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
502558005415	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
502558005416	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
502558005417	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
502558005418	active site
502558005419	HIGH motif; other site
502558005420	KMSK motif region; other site
502558005421	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
502558005422	tRNA binding surface [nucleotide binding]; other site
502558005423	anticodon binding site; other site
502558005424	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
502558005425	Coenzyme A binding pocket [chemical binding]; other site
502558005426	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
502558005427	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
502558005428	carbamate kinase; Reviewed; Region: PRK12686
502558005429	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
502558005430	putative substrate binding site [chemical binding]; other site
502558005431	nucleotide binding site [chemical binding]; other site
502558005432	nucleotide binding site [chemical binding]; other site
502558005433	homodimer interface [polypeptide binding]; other site
502558005434	ornithine carbamoyltransferase; Validated; Region: PRK02102
502558005435	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
502558005436	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
502558005437	Amidinotransferase; Region: Amidinotransf; cl12043
502558005438	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
502558005439	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
502558005440	C-terminal domain interface [polypeptide binding]; other site
502558005441	GSH binding site (G-site) [chemical binding]; other site
502558005442	dimer interface [polypeptide binding]; other site
502558005443	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558005444	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558005445	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
502558005446	dimerization interface [polypeptide binding]; other site
502558005447	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558005448	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558005449	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558005450	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
502558005451	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
502558005452	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
502558005453	active site
502558005454	DNA binding site [nucleotide binding]
502558005455	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
502558005456	DNA binding site [nucleotide binding]
502558005457	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
502558005458	nucleotide binding site [chemical binding]; other site
502558005459	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
502558005460	active site
502558005461	dimerization interface [polypeptide binding]; other site
502558005462	glutamate racemase; Provisional; Region: PRK00865
502558005463	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
502558005464	putative deacylase active site [active]
502558005465	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
502558005466	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
502558005467	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
502558005468	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
502558005469	SmpB-tmRNA interface; other site
502558005470	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
502558005471	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
502558005472	oligomer interface [polypeptide binding]; other site
502558005473	active site
502558005474	metal binding site [ion binding]; metal-binding site
502558005475	putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501
502558005476	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
502558005477	active site
502558005478	homotetramer interface [polypeptide binding]; other site
502558005479	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
502558005480	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
502558005481	GIY-YIG motif/motif A; other site
502558005482	putative active site [active]
502558005483	putative metal binding site [ion binding]; other site
502558005484	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
502558005485	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
502558005486	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
502558005487	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
502558005488	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
502558005489	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
502558005490	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
502558005491	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558005492	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
502558005493	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558005494	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558005495	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558005496	DNA binding residues [nucleotide binding]
502558005497	dimerization interface [polypeptide binding]; other site
502558005498	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
502558005499	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
502558005500	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
502558005501	active site
502558005502	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
502558005503	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
502558005504	nudix motif; other site
502558005505	Uncharacterized conserved protein [Function unknown]; Region: COG1683
502558005506	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
502558005507	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
502558005508	acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515
502558005509	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
502558005510	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
502558005511	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
502558005512	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
502558005513	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
502558005514	dimer interface [polypeptide binding]; other site
502558005515	active site
502558005516	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
502558005517	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
502558005518	NAD(P) binding site [chemical binding]; other site
502558005519	homotetramer interface [polypeptide binding]; other site
502558005520	homodimer interface [polypeptide binding]; other site
502558005521	active site
502558005522	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
502558005523	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
502558005524	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
502558005525	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
502558005526	FMN binding site [chemical binding]; other site
502558005527	substrate binding site [chemical binding]; other site
502558005528	putative catalytic residue [active]
502558005529	acyl carrier protein; Provisional; Region: acpP; PRK00982
502558005530	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
502558005531	MarR family; Region: MarR_2; pfam12802
502558005532	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
502558005533	RNB domain; Region: RNB; pfam00773
502558005534	RNB domain; Region: RNB; pfam00773
502558005535	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
502558005536	RNA binding site [nucleotide binding]; other site
502558005537	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
502558005538	protein binding site [polypeptide binding]; other site
502558005539	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
502558005540	Catalytic dyad [active]
502558005541	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
502558005542	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
502558005543	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
502558005544	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558005545	Walker A/P-loop; other site
502558005546	ATP binding site [chemical binding]; other site
502558005547	Q-loop/lid; other site
502558005548	ABC transporter signature motif; other site
502558005549	Walker B; other site
502558005550	D-loop; other site
502558005551	H-loop/switch region; other site
502558005552	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
502558005553	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
502558005554	PYR/PP interface [polypeptide binding]; other site
502558005555	dimer interface [polypeptide binding]; other site
502558005556	TPP binding site [chemical binding]; other site
502558005557	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
502558005558	transketolase; Reviewed; Region: PRK05899
502558005559	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
502558005560	TPP-binding site [chemical binding]; other site
502558005561	dimer interface [polypeptide binding]; other site
502558005562	peptide chain release factor 2; Validated; Region: prfB; PRK00578
502558005563	PCRF domain; Region: PCRF; pfam03462
502558005564	RF-1 domain; Region: RF-1; pfam00472
502558005565	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
502558005566	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
502558005567	SEC-C motif; Region: SEC-C; pfam02810
502558005568	Bacterial transcriptional activator domain; Region: BTAD; smart01043
502558005569	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
502558005570	putative active site pocket [active]
502558005571	cleavage site
502558005572	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
502558005573	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
502558005574	Cl- selectivity filter; other site
502558005575	Cl- binding residues [ion binding]; other site
502558005576	pore gating glutamate residue; other site
502558005577	dimer interface [polypeptide binding]; other site
502558005578	probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684
502558005579	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
502558005580	Oligomerisation domain; Region: Oligomerisation; pfam02410
502558005581	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
502558005582	Zn2+ binding site [ion binding]; other site
502558005583	Mg2+ binding site [ion binding]; other site
502558005584	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
502558005585	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
502558005586	active site
502558005587	(T/H)XGH motif; other site
502558005588	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
502558005589	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
502558005590	putative catalytic cysteine [active]
502558005591	gamma-glutamyl kinase; Provisional; Region: PRK05429
502558005592	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
502558005593	nucleotide binding site [chemical binding]; other site
502558005594	homotetrameric interface [polypeptide binding]; other site
502558005595	putative phosphate binding site [ion binding]; other site
502558005596	putative allosteric binding site; other site
502558005597	PUA domain; Region: PUA; pfam01472
502558005598	GTPase CgtA; Reviewed; Region: obgE; PRK12297
502558005599	GTP1/OBG; Region: GTP1_OBG; pfam01018
502558005600	Obg GTPase; Region: Obg; cd01898
502558005601	G1 box; other site
502558005602	GTP/Mg2+ binding site [chemical binding]; other site
502558005603	Switch I region; other site
502558005604	G2 box; other site
502558005605	G3 box; other site
502558005606	Switch II region; other site
502558005607	G4 box; other site
502558005608	G5 box; other site
502558005609	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
502558005610	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
502558005611	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
502558005612	DNA polymerase I; Provisional; Region: PRK05755
502558005613	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
502558005614	active site
502558005615	metal binding site 1 [ion binding]; metal-binding site
502558005616	putative 5' ssDNA interaction site; other site
502558005617	metal binding site 3; metal-binding site
502558005618	metal binding site 2 [ion binding]; metal-binding site
502558005619	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
502558005620	putative DNA binding site [nucleotide binding]; other site
502558005621	putative metal binding site [ion binding]; other site
502558005622	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
502558005623	active site
502558005624	DNA binding site [nucleotide binding]
502558005625	catalytic site [active]
502558005626	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
502558005627	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
502558005628	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
502558005629	Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143
502558005630	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
502558005631	active site
502558005632	HIGH motif; other site
502558005633	nucleotide binding site [chemical binding]; other site
502558005634	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
502558005635	KMSKS motif; other site
502558005636	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
502558005637	anticodon binding site; other site
502558005638	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
502558005639	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
502558005640	tandem repeat interface [polypeptide binding]; other site
502558005641	oligomer interface [polypeptide binding]; other site
502558005642	active site residues [active]
502558005643	transcription termination factor Rho; Provisional; Region: rho; PRK09376
502558005644	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
502558005645	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
502558005646	RNA binding site [nucleotide binding]; other site
502558005647	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
502558005648	multimer interface [polypeptide binding]; other site
502558005649	Walker A motif; other site
502558005650	ATP binding site [chemical binding]; other site
502558005651	Walker B motif; other site
502558005652	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
502558005653	active site
502558005654	intersubunit interactions; other site
502558005655	catalytic residue [active]
502558005656	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558005657	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558005658	metal binding site [ion binding]; metal-binding site
502558005659	active site
502558005660	I-site; other site
502558005661	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
502558005662	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
502558005663	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
502558005664	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
502558005665	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
502558005666	substrate binding site [chemical binding]; other site
502558005667	glutamase interaction surface [polypeptide binding]; other site
502558005668	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
502558005669	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
502558005670	catalytic residues [active]
502558005671	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
502558005672	putative active site pocket [active]
502558005673	4-fold oligomerization interface [polypeptide binding]; other site
502558005674	metal binding residues [ion binding]; metal-binding site
502558005675	3-fold/trimer interface [polypeptide binding]; other site
502558005676	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
502558005677	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
502558005678	pyridoxal 5'-phosphate binding site [chemical binding]; other site
502558005679	homodimer interface [polypeptide binding]; other site
502558005680	catalytic residue [active]
502558005681	histidinol dehydrogenase; Region: hisD; TIGR00069
502558005682	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
502558005683	NAD binding site [chemical binding]; other site
502558005684	dimerization interface [polypeptide binding]; other site
502558005685	product binding site; other site
502558005686	substrate binding site [chemical binding]; other site
502558005687	zinc binding site [ion binding]; other site
502558005688	catalytic residues [active]
502558005689	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
502558005690	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
502558005691	dimer interface [polypeptide binding]; other site
502558005692	motif 1; other site
502558005693	active site
502558005694	motif 3; other site
502558005695	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
502558005696	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
502558005697	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
502558005698	ANTAR domain; Region: ANTAR; pfam03861
502558005699	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
502558005700	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
502558005701	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
502558005702	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
502558005703	domain_subunit interface; other site
502558005704	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
502558005705	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
502558005706	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
502558005707	active site
502558005708	FMN binding site [chemical binding]; other site
502558005709	substrate binding site [chemical binding]; other site
502558005710	3Fe-4S cluster binding site [ion binding]; other site
502558005711	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
502558005712	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
502558005713	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
502558005714	putative active site [active]
502558005715	active site
502558005716	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
502558005717	Nitrogen regulatory protein P-II; Region: P-II; smart00938
502558005718	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
502558005719	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
502558005720	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
502558005721	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
502558005722	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
502558005723	Catalytic site [active]
502558005724	active site
502558005725	UTP binding site [chemical binding]; other site
502558005726	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
502558005727	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
502558005728	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
502558005729	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
502558005730	active site
502558005731	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
502558005732	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
502558005733	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
502558005734	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
502558005735	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
502558005736	pyridoxal 5'-phosphate binding site [chemical binding]; other site
502558005737	homodimer interface [polypeptide binding]; other site
502558005738	catalytic residue [active]
502558005739	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
502558005740	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
502558005741	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
502558005742	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
502558005743	GatB domain; Region: GatB_Yqey; smart00845
502558005744	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
502558005745	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
502558005746	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
502558005747	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014
502558005748	PemK-like protein; Region: PemK; pfam02452
502558005749	Predicted transcriptional regulators [Transcription]; Region: COG1695
502558005750	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
502558005751	Predicted membrane protein [Function unknown]; Region: COG4709
502558005752	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
502558005753	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
502558005754	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
502558005755	Protein of unknown function (DUF497); Region: DUF497; pfam04365
502558005756	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
502558005757	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
502558005758	ATP binding site [chemical binding]; other site
502558005759	putative Mg++ binding site [ion binding]; other site
502558005760	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
502558005761	nucleotide binding region [chemical binding]; other site
502558005762	ATP-binding site [chemical binding]; other site
502558005763	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
502558005764	HRDC domain; Region: HRDC; pfam00570
502558005765	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
502558005766	serpin-like protein; Provisional; Region: PHA02660
502558005767	reactive center loop; other site
502558005768	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
502558005769	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
502558005770	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
502558005771	active site
502558005772	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
502558005773	Ligand Binding Site [chemical binding]; other site
502558005774	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
502558005775	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
502558005776	active site
502558005777	catalytic tetrad [active]
502558005778	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
502558005779	YARHG domain; Region: YARHG; pfam13308
502558005780	ABC transporter C family member; Provisional; Region: PLN03232
502558005781	GTP-binding protein YchF; Reviewed; Region: PRK09601
502558005782	YchF GTPase; Region: YchF; cd01900
502558005783	G1 box; other site
502558005784	GTP/Mg2+ binding site [chemical binding]; other site
502558005785	Switch I region; other site
502558005786	G2 box; other site
502558005787	Switch II region; other site
502558005788	G3 box; other site
502558005789	G4 box; other site
502558005790	G5 box; other site
502558005791	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
502558005792	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
502558005793	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
502558005794	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558005795	hypothetical protein; Validated; Region: PRK07121
502558005796	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558005797	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558005798	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
502558005799	dimerization interface [polypeptide binding]; other site
502558005800	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
502558005801	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
502558005802	Ligand binding site; other site
502558005803	metal-binding site
502558005804	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
502558005805	Domain of unknown function DUF20; Region: UPF0118; pfam01594
502558005806	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
502558005807	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558005808	Walker A motif; other site
502558005809	ATP binding site [chemical binding]; other site
502558005810	Walker B motif; other site
502558005811	arginine finger; other site
502558005812	Peptidase family M41; Region: Peptidase_M41; pfam01434
502558005813	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
502558005814	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558005815	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
502558005816	Interdomain contacts; other site
502558005817	Cytokine receptor motif; other site
502558005818	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
502558005819	Interdomain contacts; other site
502558005820	Cytokine receptor motif; other site
502558005821	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
502558005822	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
502558005823	Interdomain contacts; other site
502558005824	Cytokine receptor motif; other site
502558005825	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
502558005826	Interdomain contacts; other site
502558005827	Cytokine receptor motif; other site
502558005828	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
502558005829	Interdomain contacts; other site
502558005830	Cytokine receptor motif; other site
502558005831	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
502558005832	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
502558005833	Interdomain contacts; other site
502558005834	Cytokine receptor motif; other site
502558005835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558005836	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
502558005837	active site
502558005838	phosphorylation site [posttranslational modification]
502558005839	intermolecular recognition site; other site
502558005840	dimerization interface [polypeptide binding]; other site
502558005841	LytTr DNA-binding domain; Region: LytTR; smart00850
502558005842	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
502558005843	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558005844	ATP binding site [chemical binding]; other site
502558005845	Mg2+ binding site [ion binding]; other site
502558005846	G-X-G motif; other site
502558005847	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
502558005848	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
502558005849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558005850	active site
502558005851	phosphorylation site [posttranslational modification]
502558005852	intermolecular recognition site; other site
502558005853	dimerization interface [polypeptide binding]; other site
502558005854	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
502558005855	DNA binding site [nucleotide binding]
502558005856	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
502558005857	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558005858	Walker A/P-loop; other site
502558005859	ATP binding site [chemical binding]; other site
502558005860	Q-loop/lid; other site
502558005861	ABC transporter signature motif; other site
502558005862	Walker B; other site
502558005863	D-loop; other site
502558005864	H-loop/switch region; other site
502558005865	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
502558005866	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
502558005867	dimer interface [polypeptide binding]; other site
502558005868	phosphorylation site [posttranslational modification]
502558005869	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558005870	ATP binding site [chemical binding]; other site
502558005871	Mg2+ binding site [ion binding]; other site
502558005872	G-X-G motif; other site
502558005873	peroxiredoxin; Region: AhpC; TIGR03137
502558005874	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
502558005875	dimer interface [polypeptide binding]; other site
502558005876	decamer (pentamer of dimers) interface [polypeptide binding]; other site
502558005877	catalytic triad [active]
502558005878	peroxidatic and resolving cysteines [active]
502558005879	FeoA domain; Region: FeoA; pfam04023
502558005880	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
502558005881	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
502558005882	G1 box; other site
502558005883	GTP/Mg2+ binding site [chemical binding]; other site
502558005884	Switch I region; other site
502558005885	G2 box; other site
502558005886	G3 box; other site
502558005887	Switch II region; other site
502558005888	G4 box; other site
502558005889	G5 box; other site
502558005890	Nucleoside recognition; Region: Gate; pfam07670
502558005891	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
502558005892	Nucleoside recognition; Region: Gate; pfam07670
502558005893	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
502558005894	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
502558005895	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558005896	Walker A/P-loop; other site
502558005897	ATP binding site [chemical binding]; other site
502558005898	Q-loop/lid; other site
502558005899	ABC transporter signature motif; other site
502558005900	Walker B; other site
502558005901	D-loop; other site
502558005902	H-loop/switch region; other site
502558005903	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
502558005904	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
502558005905	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558005906	Walker A/P-loop; other site
502558005907	ATP binding site [chemical binding]; other site
502558005908	Q-loop/lid; other site
502558005909	ABC transporter signature motif; other site
502558005910	Walker B; other site
502558005911	D-loop; other site
502558005912	H-loop/switch region; other site
502558005913	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
502558005914	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
502558005915	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
502558005916	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558005917	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558005918	metal binding site [ion binding]; metal-binding site
502558005919	active site
502558005920	I-site; other site
502558005921	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
502558005922	Na2 binding site [ion binding]; other site
502558005923	putative substrate binding site 1 [chemical binding]; other site
502558005924	Na binding site 1 [ion binding]; other site
502558005925	putative substrate binding site 2 [chemical binding]; other site
502558005926	Aegerolysin; Region: Aegerolysin; pfam06355
502558005927	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
502558005928	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
502558005929	active site
502558005930	metal binding site [ion binding]; metal-binding site
502558005931	Protein of unknown function (DUF3232); Region: DUF3232; pfam11554
502558005932	histidyl-tRNA synthetase; Region: hisS; TIGR00442
502558005933	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
502558005934	dimer interface [polypeptide binding]; other site
502558005935	motif 1; other site
502558005936	active site
502558005937	motif 2; other site
502558005938	motif 3; other site
502558005939	stage V sporulation protein K; Region: spore_V_K; TIGR02881
502558005940	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558005941	Walker A motif; other site
502558005942	ATP binding site [chemical binding]; other site
502558005943	Walker B motif; other site
502558005944	arginine finger; other site
502558005945	stage V sporulation protein K; Region: spore_V_K; TIGR02881
502558005946	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558005947	Walker A motif; other site
502558005948	ATP binding site [chemical binding]; other site
502558005949	Walker B motif; other site
502558005950	arginine finger; other site
502558005951	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
502558005952	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
502558005953	active site
502558005954	metal binding site [ion binding]; metal-binding site
502558005955	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
502558005956	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
502558005957	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
502558005958	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
502558005959	active site
502558005960	dimer interface [polypeptide binding]; other site
502558005961	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
502558005962	Ligand Binding Site [chemical binding]; other site
502558005963	Molecular Tunnel; other site
502558005964	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
502558005965	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
502558005966	dimerization interface 3.5A [polypeptide binding]; other site
502558005967	active site
502558005968	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
502558005969	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
502558005970	active site
502558005971	PHP Thumb interface [polypeptide binding]; other site
502558005972	metal binding site [ion binding]; metal-binding site
502558005973	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
502558005974	generic binding surface II; other site
502558005975	generic binding surface I; other site
502558005976	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558005977	non-specific DNA binding site [nucleotide binding]; other site
502558005978	salt bridge; other site
502558005979	sequence-specific DNA binding site [nucleotide binding]; other site
502558005980	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
502558005981	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
502558005982	gamma subunit interface [polypeptide binding]; other site
502558005983	epsilon subunit interface [polypeptide binding]; other site
502558005984	LBP interface [polypeptide binding]; other site
502558005985	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
502558005986	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
502558005987	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
502558005988	alpha subunit interaction interface [polypeptide binding]; other site
502558005989	Walker A motif; other site
502558005990	ATP binding site [chemical binding]; other site
502558005991	Walker B motif; other site
502558005992	inhibitor binding site; inhibition site
502558005993	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
502558005994	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
502558005995	core domain interface [polypeptide binding]; other site
502558005996	delta subunit interface [polypeptide binding]; other site
502558005997	epsilon subunit interface [polypeptide binding]; other site
502558005998	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
502558005999	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
502558006000	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
502558006001	beta subunit interaction interface [polypeptide binding]; other site
502558006002	Walker A motif; other site
502558006003	ATP binding site [chemical binding]; other site
502558006004	Walker B motif; other site
502558006005	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
502558006006	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712
502558006007	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
502558006008	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
502558006009	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
502558006010	ATP synthase subunit C; Region: ATP-synt_C; cl00466
502558006011	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
502558006012	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
502558006013	catalytic motif [active]
502558006014	Zn binding site [ion binding]; other site
502558006015	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
502558006016	active site
502558006017	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
502558006018	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
502558006019	dimer interface [polypeptide binding]; other site
502558006020	active site
502558006021	glycine-pyridoxal phosphate binding site [chemical binding]; other site
502558006022	folate binding site [chemical binding]; other site
502558006023	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
502558006024	glycerol kinase; Provisional; Region: glpK; PRK00047
502558006025	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
502558006026	N- and C-terminal domain interface [polypeptide binding]; other site
502558006027	active site
502558006028	MgATP binding site [chemical binding]; other site
502558006029	catalytic site [active]
502558006030	metal binding site [ion binding]; metal-binding site
502558006031	glycerol binding site [chemical binding]; other site
502558006032	homotetramer interface [polypeptide binding]; other site
502558006033	homodimer interface [polypeptide binding]; other site
502558006034	FBP binding site [chemical binding]; other site
502558006035	protein IIAGlc interface [polypeptide binding]; other site
502558006036	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
502558006037	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
502558006038	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
502558006039	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
502558006040	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
502558006041	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
502558006042	Walker A/P-loop; other site
502558006043	ATP binding site [chemical binding]; other site
502558006044	Q-loop/lid; other site
502558006045	ABC transporter signature motif; other site
502558006046	Walker B; other site
502558006047	D-loop; other site
502558006048	H-loop/switch region; other site
502558006049	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
502558006050	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
502558006051	Walker A/P-loop; other site
502558006052	ATP binding site [chemical binding]; other site
502558006053	Q-loop/lid; other site
502558006054	ABC transporter signature motif; other site
502558006055	Walker B; other site
502558006056	D-loop; other site
502558006057	H-loop/switch region; other site
502558006058	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
502558006059	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
502558006060	DNA binding site [nucleotide binding]
502558006061	active site
502558006062	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
502558006063	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
502558006064	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558006065	Walker A motif; other site
502558006066	ATP binding site [chemical binding]; other site
502558006067	Walker B motif; other site
502558006068	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
502558006069	flavoprotein, HI0933 family; Region: TIGR00275
502558006070	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
502558006071	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
502558006072	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
502558006073	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
502558006074	Predicted membrane protein [Function unknown]; Region: COG3601
502558006075	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
502558006076	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
502558006077	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
502558006078	Walker A/P-loop; other site
502558006079	ATP binding site [chemical binding]; other site
502558006080	Q-loop/lid; other site
502558006081	ABC transporter signature motif; other site
502558006082	Walker B; other site
502558006083	D-loop; other site
502558006084	H-loop/switch region; other site
502558006085	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
502558006086	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
502558006087	Walker A/P-loop; other site
502558006088	ATP binding site [chemical binding]; other site
502558006089	Q-loop/lid; other site
502558006090	ABC transporter signature motif; other site
502558006091	Walker B; other site
502558006092	D-loop; other site
502558006093	H-loop/switch region; other site
502558006094	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
502558006095	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
502558006096	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
502558006097	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558006098	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558006099	non-specific DNA binding site [nucleotide binding]; other site
502558006100	salt bridge; other site
502558006101	sequence-specific DNA binding site [nucleotide binding]; other site
502558006102	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558006103	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558006104	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006105	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006106	dimerization interface [polypeptide binding]; other site
502558006107	DNA binding residues [nucleotide binding]
502558006108	protein-export membrane protein SecD; Region: secD; TIGR01129
502558006109	Protein export membrane protein; Region: SecD_SecF; cl14618
502558006110	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
502558006111	Protein export membrane protein; Region: SecD_SecF; pfam02355
502558006112	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
502558006113	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
502558006114	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
502558006115	Uncharacterized BCR, COG1636; Region: DUF208; cl17782
502558006116	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
502558006117	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
502558006118	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
502558006119	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
502558006120	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
502558006121	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
502558006122	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
502558006123	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
502558006124	Major Facilitator Superfamily; Region: MFS_1; pfam07690
502558006125	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
502558006126	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
502558006127	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558006128	active site
502558006129	phosphorylation site [posttranslational modification]
502558006130	intermolecular recognition site; other site
502558006131	dimerization interface [polypeptide binding]; other site
502558006132	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
502558006133	DNA binding site [nucleotide binding]
502558006134	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
502558006135	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
502558006136	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
502558006137	dimer interface [polypeptide binding]; other site
502558006138	phosphorylation site [posttranslational modification]
502558006139	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558006140	ATP binding site [chemical binding]; other site
502558006141	Mg2+ binding site [ion binding]; other site
502558006142	G-X-G motif; other site
502558006143	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
502558006144	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
502558006145	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
502558006146	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
502558006147	DNA-binding site [nucleotide binding]; DNA binding site
502558006148	RNA-binding motif; other site
502558006149	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835
502558006150	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558006151	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
502558006152	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558006153	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
502558006154	dimerization interface [polypeptide binding]; other site
502558006155	substrate binding pocket [chemical binding]; other site
502558006156	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
502558006157	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558006158	Walker A motif; other site
502558006159	ATP binding site [chemical binding]; other site
502558006160	Walker B motif; other site
502558006161	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
502558006162	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
502558006163	RuvA N terminal domain; Region: RuvA_N; pfam01330
502558006164	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
502558006165	active site
502558006166	putative DNA-binding cleft [nucleotide binding]; other site
502558006167	dimer interface [polypeptide binding]; other site
502558006168	hypothetical protein; Validated; Region: PRK00110
502558006169	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
502558006170	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
502558006171	heme binding site [chemical binding]; other site
502558006172	ferroxidase pore; other site
502558006173	ferroxidase diiron center [ion binding]; other site
502558006174	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
502558006175	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
502558006176	putative ligand binding site [chemical binding]; other site
502558006177	putative NAD binding site [chemical binding]; other site
502558006178	putative catalytic site [active]
502558006179	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
502558006180	L-serine binding site [chemical binding]; other site
502558006181	ACT domain interface; other site
502558006182	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558006183	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558006184	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
502558006185	dimerization interface [polypeptide binding]; other site
502558006186	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558006187	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558006188	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
502558006189	active site
502558006190	oxyanion hole [active]
502558006191	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
502558006192	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
502558006193	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
502558006194	trimer interface [polypeptide binding]; other site
502558006195	dimer interface [polypeptide binding]; other site
502558006196	putative active site [active]
502558006197	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
502558006198	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
502558006199	FeS/SAM binding site; other site
502558006200	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
502558006201	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558006202	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
502558006203	Walker A/P-loop; other site
502558006204	ATP binding site [chemical binding]; other site
502558006205	Q-loop/lid; other site
502558006206	ABC transporter signature motif; other site
502558006207	Walker B; other site
502558006208	D-loop; other site
502558006209	H-loop/switch region; other site
502558006210	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
502558006211	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
502558006212	dimer interface [polypeptide binding]; other site
502558006213	conserved gate region; other site
502558006214	putative PBP binding loops; other site
502558006215	ABC-ATPase subunit interface; other site
502558006216	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
502558006217	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
502558006218	enoyl-CoA hydratase; Provisional; Region: PRK08252
502558006219	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
502558006220	substrate binding site [chemical binding]; other site
502558006221	oxyanion hole (OAH) forming residues; other site
502558006222	trimer interface [polypeptide binding]; other site
502558006223	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
502558006224	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
502558006225	Walker A/P-loop; other site
502558006226	ATP binding site [chemical binding]; other site
502558006227	Q-loop/lid; other site
502558006228	ABC transporter signature motif; other site
502558006229	Walker B; other site
502558006230	D-loop; other site
502558006231	H-loop/switch region; other site
502558006232	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
502558006233	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
502558006234	Walker A/P-loop; other site
502558006235	ATP binding site [chemical binding]; other site
502558006236	Q-loop/lid; other site
502558006237	ABC transporter signature motif; other site
502558006238	Walker B; other site
502558006239	D-loop; other site
502558006240	H-loop/switch region; other site
502558006241	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
502558006242	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
502558006243	dimer interface [polypeptide binding]; other site
502558006244	conserved gate region; other site
502558006245	putative PBP binding loops; other site
502558006246	ABC-ATPase subunit interface; other site
502558006247	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
502558006248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
502558006249	dimer interface [polypeptide binding]; other site
502558006250	conserved gate region; other site
502558006251	putative PBP binding loops; other site
502558006252	ABC-ATPase subunit interface; other site
502558006253	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
502558006254	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
502558006255	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
502558006256	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
502558006257	nucleotide binding pocket [chemical binding]; other site
502558006258	K-X-D-G motif; other site
502558006259	catalytic site [active]
502558006260	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
502558006261	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
502558006262	Helix-hairpin-helix motif; Region: HHH; pfam00633
502558006263	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
502558006264	Dimer interface [polypeptide binding]; other site
502558006265	BRCT sequence motif; other site
502558006266	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
502558006267	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
502558006268	putative substrate binding site [chemical binding]; other site
502558006269	putative ATP binding site [chemical binding]; other site
502558006270	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
502558006271	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
502558006272	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
502558006273	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
502558006274	active site
502558006275	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
502558006276	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
502558006277	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
502558006278	glutaminase active site [active]
502558006279	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
502558006280	dimer interface [polypeptide binding]; other site
502558006281	active site
502558006282	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
502558006283	dimer interface [polypeptide binding]; other site
502558006284	active site
502558006285	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
502558006286	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
502558006287	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
502558006288	active site
502558006289	FMN binding site [chemical binding]; other site
502558006290	substrate binding site [chemical binding]; other site
502558006291	putative catalytic residue [active]
502558006292	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
502558006293	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
502558006294	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
502558006295	dimer interface [polypeptide binding]; other site
502558006296	active site
502558006297	metal binding site [ion binding]; metal-binding site
502558006298	glutathione binding site [chemical binding]; other site
502558006299	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
502558006300	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558006301	Q-loop/lid; other site
502558006302	ABC transporter signature motif; other site
502558006303	Walker B; other site
502558006304	D-loop; other site
502558006305	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
502558006306	LytTr DNA-binding domain; Region: LytTR; pfam04397
502558006307	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
502558006308	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
502558006309	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
502558006310	Walker A/P-loop; other site
502558006311	ATP binding site [chemical binding]; other site
502558006312	Q-loop/lid; other site
502558006313	ABC transporter signature motif; other site
502558006314	Walker B; other site
502558006315	D-loop; other site
502558006316	H-loop/switch region; other site
502558006317	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
502558006318	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
502558006319	Cna protein B-type domain; Region: Cna_B; pfam05738
502558006320	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
502558006321	elongation factor G; Reviewed; Region: PRK12740
502558006322	G1 box; other site
502558006323	putative GEF interaction site [polypeptide binding]; other site
502558006324	GTP/Mg2+ binding site [chemical binding]; other site
502558006325	Switch I region; other site
502558006326	G2 box; other site
502558006327	G3 box; other site
502558006328	Switch II region; other site
502558006329	G4 box; other site
502558006330	G5 box; other site
502558006331	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
502558006332	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
502558006333	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
502558006334	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
502558006335	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
502558006336	FtsX-like permease family; Region: FtsX; pfam02687
502558006337	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
502558006338	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
502558006339	Walker A/P-loop; other site
502558006340	ATP binding site [chemical binding]; other site
502558006341	Q-loop/lid; other site
502558006342	ABC transporter signature motif; other site
502558006343	Walker B; other site
502558006344	D-loop; other site
502558006345	H-loop/switch region; other site
502558006346	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
502558006347	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
502558006348	HlyD family secretion protein; Region: HlyD_3; pfam13437
502558006349	FAD binding domain; Region: FAD_binding_2; pfam00890
502558006350	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558006351	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006352	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006353	DNA binding residues [nucleotide binding]
502558006354	dimerization interface [polypeptide binding]; other site
502558006355	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006356	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006357	DNA binding residues [nucleotide binding]
502558006358	dimerization interface [polypeptide binding]; other site
502558006359	precorrin 3B synthase CobZ; Region: CobZ_N-term; TIGR02485
502558006360	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558006361	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
502558006362	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
502558006363	dimer interface [polypeptide binding]; other site
502558006364	motif 1; other site
502558006365	active site
502558006366	motif 2; other site
502558006367	motif 3; other site
502558006368	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
502558006369	anticodon binding site; other site
502558006370	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
502558006371	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
502558006372	Walker A/P-loop; other site
502558006373	ATP binding site [chemical binding]; other site
502558006374	Q-loop/lid; other site
502558006375	ABC transporter signature motif; other site
502558006376	Walker B; other site
502558006377	D-loop; other site
502558006378	H-loop/switch region; other site
502558006379	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
502558006380	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
502558006381	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558006382	active site
502558006383	phosphorylation site [posttranslational modification]
502558006384	intermolecular recognition site; other site
502558006385	dimerization interface [polypeptide binding]; other site
502558006386	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
502558006387	DNA binding site [nucleotide binding]
502558006388	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
502558006389	HAMP domain; Region: HAMP; pfam00672
502558006390	dimerization interface [polypeptide binding]; other site
502558006391	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
502558006392	dimer interface [polypeptide binding]; other site
502558006393	phosphorylation site [posttranslational modification]
502558006394	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558006395	ATP binding site [chemical binding]; other site
502558006396	Mg2+ binding site [ion binding]; other site
502558006397	G-X-G motif; other site
502558006398	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
502558006399	TPR motif; other site
502558006400	TPR repeat; Region: TPR_11; pfam13414
502558006401	binding surface
502558006402	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
502558006403	Predicted transcriptional regulators [Transcription]; Region: COG1695
502558006404	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
502558006405	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
502558006406	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
502558006407	tetramer interface [polypeptide binding]; other site
502558006408	heme binding pocket [chemical binding]; other site
502558006409	NADPH binding site [chemical binding]; other site
502558006410	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
502558006411	tartrate dehydrogenase; Region: TTC; TIGR02089
502558006412	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
502558006413	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
502558006414	substrate binding site [chemical binding]; other site
502558006415	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
502558006416	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
502558006417	substrate binding site [chemical binding]; other site
502558006418	ligand binding site [chemical binding]; other site
502558006419	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
502558006420	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
502558006421	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
502558006422	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
502558006423	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
502558006424	substrate binding pocket [chemical binding]; other site
502558006425	chain length determination region; other site
502558006426	substrate-Mg2+ binding site; other site
502558006427	catalytic residues [active]
502558006428	aspartate-rich region 1; other site
502558006429	active site lid residues [active]
502558006430	aspartate-rich region 2; other site
502558006431	exopolyphosphatase; Region: exo_poly_only; TIGR03706
502558006432	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
502558006433	Septum formation initiator; Region: DivIC; pfam04977
502558006434	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
502558006435	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
502558006436	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
502558006437	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
502558006438	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
502558006439	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
502558006440	G1 box; other site
502558006441	GTP/Mg2+ binding site [chemical binding]; other site
502558006442	Switch I region; other site
502558006443	G2 box; other site
502558006444	G3 box; other site
502558006445	Switch II region; other site
502558006446	G4 box; other site
502558006447	G5 box; other site
502558006448	Nucleoside recognition; Region: Gate; pfam07670
502558006449	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
502558006450	Nucleoside recognition; Region: Gate; pfam07670
502558006451	FeoA domain; Region: FeoA; pfam04023
502558006452	FeoA domain; Region: FeoA; pfam04023
502558006453	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
502558006454	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
502558006455	pyridoxal 5'-phosphate binding site [chemical binding]; other site
502558006456	catalytic residue [active]
502558006457	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
502558006458	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558006459	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
502558006460	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
502558006461	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
502558006462	4Fe-4S binding domain; Region: Fer4; cl02805
502558006463	tetrathionate reductase subunit A; Provisional; Region: PRK14991
502558006464	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558006465	molybdopterin cofactor binding site; other site
502558006466	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
502558006467	molybdopterin cofactor binding site; other site
502558006468	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006469	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006470	DNA binding residues [nucleotide binding]
502558006471	dimerization interface [polypeptide binding]; other site
502558006472	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006473	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558006474	active site
502558006475	phosphorylation site [posttranslational modification]
502558006476	intermolecular recognition site; other site
502558006477	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006478	DNA binding residues [nucleotide binding]
502558006479	dimerization interface [polypeptide binding]; other site
502558006480	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
502558006481	Histidine kinase; Region: HisKA_3; pfam07730
502558006482	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558006483	ATP binding site [chemical binding]; other site
502558006484	Mg2+ binding site [ion binding]; other site
502558006485	G-X-G motif; other site
502558006486	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
502558006487	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
502558006488	Walker A/P-loop; other site
502558006489	ATP binding site [chemical binding]; other site
502558006490	Q-loop/lid; other site
502558006491	ABC transporter signature motif; other site
502558006492	Walker B; other site
502558006493	D-loop; other site
502558006494	H-loop/switch region; other site
502558006495	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
502558006496	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
502558006497	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
502558006498	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
502558006499	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
502558006500	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
502558006501	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
502558006502	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
502558006503	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
502558006504	ATP binding site [chemical binding]; other site
502558006505	Walker A motif; other site
502558006506	hexamer interface [polypeptide binding]; other site
502558006507	Walker B motif; other site
502558006508	AAA domain; Region: AAA_31; pfam13614
502558006509	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
502558006510	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
502558006511	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
502558006512	Predicted membrane protein [Function unknown]; Region: COG2364
502558006513	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
502558006514	propionate/acetate kinase; Provisional; Region: PRK12379
502558006515	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
502558006516	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
502558006517	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
502558006518	hypothetical protein; Validated; Region: PRK07121
502558006519	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558006520	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006521	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006522	DNA binding residues [nucleotide binding]
502558006523	dimerization interface [polypeptide binding]; other site
502558006524	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
502558006525	tricarballylate dehydrogenase; Validated; Region: PRK08274
502558006526	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006527	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006528	DNA binding residues [nucleotide binding]
502558006529	dimerization interface [polypeptide binding]; other site
502558006530	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
502558006531	Ligand Binding Site [chemical binding]; other site
502558006532	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558006533	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558006534	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
502558006535	dimerization interface [polypeptide binding]; other site
502558006536	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558006537	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558006538	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558006539	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558006540	metal binding site [ion binding]; metal-binding site
502558006541	active site
502558006542	I-site; other site
502558006543	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
502558006544	PAS domain S-box; Region: sensory_box; TIGR00229
502558006545	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
502558006546	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558006547	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
502558006548	putative molybdopterin cofactor binding site; other site
502558006549	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558006550	molybdopterin cofactor binding site; other site
502558006551	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558006552	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
502558006553	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
502558006554	4Fe-4S binding domain; Region: Fer4; pfam00037
502558006555	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
502558006556	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
502558006557	4Fe-4S binding domain; Region: Fer4; cl02805
502558006558	TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518
502558006559	thiosulfate reductase PhsA; Provisional; Region: PRK15488
502558006560	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
502558006561	putative [Fe4-S4] binding site [ion binding]; other site
502558006562	putative molybdopterin cofactor binding site [chemical binding]; other site
502558006563	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
502558006564	putative molybdopterin cofactor binding site; other site
502558006565	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006566	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006567	DNA binding residues [nucleotide binding]
502558006568	dimerization interface [polypeptide binding]; other site
502558006569	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
502558006570	putative active site [active]
502558006571	putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134
502558006572	L-aspartate oxidase; Provisional; Region: PRK06175
502558006573	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006574	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006575	DNA binding residues [nucleotide binding]
502558006576	dimerization interface [polypeptide binding]; other site
502558006577	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
502558006578	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
502558006579	active site
502558006580	FMN binding site [chemical binding]; other site
502558006581	substrate binding site [chemical binding]; other site
502558006582	putative catalytic residue [active]
502558006583	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
502558006584	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
502558006585	tetramer interface [polypeptide binding]; other site
502558006586	pyridoxal 5'-phosphate binding site [chemical binding]; other site
502558006587	catalytic residue [active]
502558006588	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
502558006589	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
502558006590	HIGH motif; other site
502558006591	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
502558006592	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
502558006593	active site
502558006594	KMSKS motif; other site
502558006595	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
502558006596	tRNA binding surface [nucleotide binding]; other site
502558006597	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
502558006598	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006599	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006600	DNA binding residues [nucleotide binding]
502558006601	dimerization interface [polypeptide binding]; other site
502558006602	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558006603	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
502558006604	putative active site [active]
502558006605	metal binding site [ion binding]; metal-binding site
502558006606	hypothetical protein; Validated; Region: PRK07121
502558006607	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558006608	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006609	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006610	DNA binding residues [nucleotide binding]
502558006611	dimerization interface [polypeptide binding]; other site
502558006612	Protein of unknown function (DUF328); Region: DUF328; pfam03883
502558006613	Divergent AAA domain; Region: AAA_4; pfam04326
502558006614	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
502558006615	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
502558006616	2-ketoisovalerate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11864
502558006617	Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376
502558006618	TPP-binding site [chemical binding]; other site
502558006619	putative dimer interface [polypeptide binding]; other site
502558006620	pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367
502558006621	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
502558006622	dimer interface [polypeptide binding]; other site
502558006623	PYR/PP interface [polypeptide binding]; other site
502558006624	TPP binding site [chemical binding]; other site
502558006625	substrate binding site [chemical binding]; other site
502558006626	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
502558006627	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
502558006628	pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028
502558006629	4Fe-4S binding domain; Region: Fer4; pfam00037
502558006630	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
502558006631	dimerization interface [polypeptide binding]; other site
502558006632	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
502558006633	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558006634	acyl-activating enzyme (AAE) consensus motif; other site
502558006635	AMP binding site [chemical binding]; other site
502558006636	active site
502558006637	CoA binding site [chemical binding]; other site
502558006638	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
502558006639	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
502558006640	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558006641	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558006642	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
502558006643	dimerization interface [polypeptide binding]; other site
502558006644	VanW like protein; Region: VanW; pfam04294
502558006645	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107
502558006646	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
502558006647	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602
502558006648	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
502558006649	active site
502558006650	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006651	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006652	DNA binding residues [nucleotide binding]
502558006653	dimerization interface [polypeptide binding]; other site
502558006654	FMN-binding domain; Region: FMN_bind; cl01081
502558006655	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558006656	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558006657	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
502558006658	Divergent AAA domain; Region: AAA_4; pfam04326
502558006659	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
502558006660	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
502558006661	putative DNA binding site [nucleotide binding]; other site
502558006662	putative Zn2+ binding site [ion binding]; other site
502558006663	hypothetical protein; Validated; Region: PRK07121
502558006664	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558006665	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006666	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006667	DNA binding residues [nucleotide binding]
502558006668	dimerization interface [polypeptide binding]; other site
502558006669	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558006670	sequence-specific DNA binding site [nucleotide binding]; other site
502558006671	salt bridge; other site
502558006672	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
502558006673	Na2 binding site [ion binding]; other site
502558006674	putative substrate binding site 1 [chemical binding]; other site
502558006675	Na binding site 1 [ion binding]; other site
502558006676	putative substrate binding site 2 [chemical binding]; other site
502558006677	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
502558006678	ApbE family; Region: ApbE; pfam02424
502558006679	Methyltransferase domain; Region: Methyltransf_11; pfam08241
502558006680	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
502558006681	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
502558006682	oligomer interface [polypeptide binding]; other site
502558006683	putative active site [active]
502558006684	metal binding site [ion binding]; metal-binding site
502558006685	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
502558006686	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
502558006687	Walker A/P-loop; other site
502558006688	ATP binding site [chemical binding]; other site
502558006689	Q-loop/lid; other site
502558006690	ABC transporter signature motif; other site
502558006691	Walker B; other site
502558006692	D-loop; other site
502558006693	H-loop/switch region; other site
502558006694	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
502558006695	FtsX-like permease family; Region: FtsX; pfam02687
502558006696	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
502558006697	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
502558006698	TrkA-C domain; Region: TrkA_C; pfam02080
502558006699	Rubrerythrin [Energy production and conversion]; Region: COG1592
502558006700	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
502558006701	binuclear metal center [ion binding]; other site
502558006702	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
502558006703	iron binding site [ion binding]; other site
502558006704	FMN-binding domain; Region: FMN_bind; cl01081
502558006705	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558006706	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006707	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006708	DNA binding residues [nucleotide binding]
502558006709	dimerization interface [polypeptide binding]; other site
502558006710	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
502558006711	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
502558006712	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
502558006713	DNA-binding site [nucleotide binding]; DNA binding site
502558006714	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
502558006715	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
502558006716	4Fe-4S binding domain; Region: Fer4; cl02805
502558006717	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558006718	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
502558006719	molybdopterin cofactor binding site; other site
502558006720	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
502558006721	molybdopterin cofactor binding site; other site
502558006722	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
502558006723	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
502558006724	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
502558006725	Catalytic site; other site
502558006726	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
502558006727	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
502558006728	active site
502558006729	metal binding site [ion binding]; metal-binding site
502558006730	homotetramer interface [polypeptide binding]; other site
502558006731	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
502558006732	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
502558006733	putative dimer interface [polypeptide binding]; other site
502558006734	NAD-dependent deacetylase; Provisional; Region: PRK00481
502558006735	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
502558006736	NAD+ binding site [chemical binding]; other site
502558006737	substrate binding site [chemical binding]; other site
502558006738	Zn binding site [ion binding]; other site
502558006739	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
502558006740	dimer interface [polypeptide binding]; other site
502558006741	ADP-ribose binding site [chemical binding]; other site
502558006742	active site
502558006743	nudix motif; other site
502558006744	metal binding site [ion binding]; metal-binding site
502558006745	Isochorismatase family; Region: Isochorismatase; pfam00857
502558006746	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
502558006747	catalytic triad [active]
502558006748	conserved cis-peptide bond; other site
502558006749	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
502558006750	Zn2+ binding site [ion binding]; other site
502558006751	Mg2+ binding site [ion binding]; other site
502558006752	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
502558006753	Zn2+ binding site [ion binding]; other site
502558006754	Mg2+ binding site [ion binding]; other site
502558006755	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
502558006756	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
502558006757	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558006758	Trp repressor protein; Region: Trp_repressor; cl17266
502558006759	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
502558006760	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
502558006761	active site
502558006762	catalytic residues [active]
502558006763	metal binding site [ion binding]; metal-binding site
502558006764	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
502558006765	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
502558006766	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
502558006767	homodimer interface [polypeptide binding]; other site
502558006768	substrate-cofactor binding pocket; other site
502558006769	catalytic residue [active]
502558006770	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
502558006771	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
502558006772	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
502558006773	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
502558006774	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006775	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006776	DNA binding residues [nucleotide binding]
502558006777	dimerization interface [polypeptide binding]; other site
502558006778	hypothetical protein; Validated; Region: PRK07121
502558006779	EthD domain; Region: EthD; cl17553
502558006780	EthD domain; Region: EthD; pfam07110
502558006781	SnoaL-like domain; Region: SnoaL_4; pfam13577
502558006782	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
502558006783	classical (c) SDRs; Region: SDR_c; cd05233
502558006784	NAD(P) binding site [chemical binding]; other site
502558006785	active site
502558006786	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
502558006787	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
502558006788	NAD(P) binding site [chemical binding]; other site
502558006789	active site
502558006790	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
502558006791	classical (c) SDRs; Region: SDR_c; cd05233
502558006792	NAD(P) binding site [chemical binding]; other site
502558006793	active site
502558006794	EthD domain; Region: EthD; pfam07110
502558006795	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558006796	putative substrate translocation pore; other site
502558006797	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
502558006798	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
502558006799	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
502558006800	active site
502558006801	FMN binding site [chemical binding]; other site
502558006802	substrate binding site [chemical binding]; other site
502558006803	putative catalytic residue [active]
502558006804	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
502558006805	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
502558006806	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
502558006807	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
502558006808	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
502558006809	active site
502558006810	FMN binding site [chemical binding]; other site
502558006811	substrate binding site [chemical binding]; other site
502558006812	putative catalytic residue [active]
502558006813	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
502558006814	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
502558006815	EthD domain; Region: EthD; pfam07110
502558006816	EthD domain; Region: EthD; cl17553
502558006817	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558006818	metabolite-proton symporter; Region: 2A0106; TIGR00883
502558006819	putative substrate translocation pore; other site
502558006820	EthD domain; Region: EthD; cl17553
502558006821	Predicted transcriptional regulators [Transcription]; Region: COG1733
502558006822	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
502558006823	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
502558006824	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
502558006825	23S rRNA interface [nucleotide binding]; other site
502558006826	L3 interface [polypeptide binding]; other site
502558006827	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
502558006828	FAD binding domain; Region: FAD_binding_2; pfam00890
502558006829	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558006830	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006831	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006832	DNA binding residues [nucleotide binding]
502558006833	dimerization interface [polypeptide binding]; other site
502558006834	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
502558006835	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
502558006836	homodimer interface [polypeptide binding]; other site
502558006837	substrate-cofactor binding pocket; other site
502558006838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
502558006839	catalytic residue [active]
502558006840	Homoserine O-succinyltransferase; Region: HTS; pfam04204
502558006841	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
502558006842	proposed active site lysine [active]
502558006843	conserved cys residue [active]
502558006844	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558006845	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558006846	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
502558006847	dimerization interface [polypeptide binding]; other site
502558006848	hypothetical protein; Validated; Region: PRK07121
502558006849	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
502558006850	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
502558006851	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
502558006852	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
502558006853	motif II; other site
502558006854	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
502558006855	active site
502558006856	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558006857	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558006858	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006859	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006860	DNA binding residues [nucleotide binding]
502558006861	dimerization interface [polypeptide binding]; other site
502558006862	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
502558006863	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
502558006864	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
502558006865	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
502558006866	CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; cl11685
502558006867	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
502558006868	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
502558006869	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
502558006870	HSP70 interaction site [polypeptide binding]; other site
502558006871	TFIIH C1-like domain; Region: C1_4; cl06838
502558006872	homoserine dehydrogenase; Provisional; Region: PRK06349
502558006873	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
502558006874	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
502558006875	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
502558006876	diaminopimelate decarboxylase; Region: lysA; TIGR01048
502558006877	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
502558006878	active site
502558006879	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
502558006880	substrate binding site [chemical binding]; other site
502558006881	catalytic residues [active]
502558006882	dimer interface [polypeptide binding]; other site
502558006883	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
502558006884	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
502558006885	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
502558006886	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558006887	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558006888	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
502558006889	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558006890	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558006891	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558006892	DNA binding residues [nucleotide binding]
502558006893	dimerization interface [polypeptide binding]; other site
502558006894	adenylate kinase; Reviewed; Region: adk; PRK00279
502558006895	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
502558006896	AMP-binding site [chemical binding]; other site
502558006897	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
502558006898	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
502558006899	SecY translocase; Region: SecY; pfam00344
502558006900	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
502558006901	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
502558006902	23S rRNA binding site [nucleotide binding]; other site
502558006903	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
502558006904	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
502558006905	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
502558006906	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
502558006907	5S rRNA interface [nucleotide binding]; other site
502558006908	L27 interface [polypeptide binding]; other site
502558006909	23S rRNA interface [nucleotide binding]; other site
502558006910	L5 interface [polypeptide binding]; other site
502558006911	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
502558006912	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
502558006913	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
502558006914	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
502558006915	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
502558006916	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
502558006917	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
502558006918	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
502558006919	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
502558006920	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
502558006921	RNA binding site [nucleotide binding]; other site
502558006922	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
502558006923	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
502558006924	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
502558006925	23S rRNA interface [nucleotide binding]; other site
502558006926	putative translocon interaction site; other site
502558006927	signal recognition particle (SRP54) interaction site; other site
502558006928	L23 interface [polypeptide binding]; other site
502558006929	trigger factor interaction site; other site
502558006930	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
502558006931	23S rRNA interface [nucleotide binding]; other site
502558006932	5S rRNA interface [nucleotide binding]; other site
502558006933	putative antibiotic binding site [chemical binding]; other site
502558006934	L25 interface [polypeptide binding]; other site
502558006935	L27 interface [polypeptide binding]; other site
502558006936	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
502558006937	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
502558006938	G-X-X-G motif; other site
502558006939	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
502558006940	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
502558006941	putative translocon binding site; other site
502558006942	protein-rRNA interface [nucleotide binding]; other site
502558006943	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
502558006944	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
502558006945	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
502558006946	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
502558006947	trigger factor; Region: tig; TIGR00115
502558006948	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
502558006949	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
502558006950	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
502558006951	Bacterial type III secretion protein (HrpB7); Region: HrpB7; cl09720
502558006952	FtsX-like permease family; Region: FtsX; pfam02687
502558006953	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
502558006954	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
502558006955	FtsX-like permease family; Region: FtsX; pfam02687
502558006956	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
502558006957	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
502558006958	Walker A/P-loop; other site
502558006959	ATP binding site [chemical binding]; other site
502558006960	Q-loop/lid; other site
502558006961	ABC transporter signature motif; other site
502558006962	Walker B; other site
502558006963	D-loop; other site
502558006964	H-loop/switch region; other site
502558006965	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
502558006966	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
502558006967	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
502558006968	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
502558006969	elongation factor G; Reviewed; Region: PRK00007
502558006970	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
502558006971	G1 box; other site
502558006972	putative GEF interaction site [polypeptide binding]; other site
502558006973	GTP/Mg2+ binding site [chemical binding]; other site
502558006974	Switch I region; other site
502558006975	G2 box; other site
502558006976	G3 box; other site
502558006977	Switch II region; other site
502558006978	G4 box; other site
502558006979	G5 box; other site
502558006980	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
502558006981	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
502558006982	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
502558006983	30S ribosomal protein S7; Validated; Region: PRK05302
502558006984	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
502558006985	S17 interaction site [polypeptide binding]; other site
502558006986	S8 interaction site; other site
502558006987	16S rRNA interaction site [nucleotide binding]; other site
502558006988	streptomycin interaction site [chemical binding]; other site
502558006989	23S rRNA interaction site [nucleotide binding]; other site
502558006990	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
502558006991	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
502558006992	peptidase T-like protein; Region: PepT-like; TIGR01883
502558006993	metal binding site [ion binding]; metal-binding site
502558006994	putative dimer interface [polypeptide binding]; other site
502558006995	Nitroreductase family; Region: Nitroreductase; pfam00881
502558006996	FMN binding site [chemical binding]; other site
502558006997	dimer interface [polypeptide binding]; other site
502558006998	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558006999	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558007000	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558007001	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558007002	DNA binding residues [nucleotide binding]
502558007003	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
502558007004	FOG: CBS domain [General function prediction only]; Region: COG0517
502558007005	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
502558007006	DHH family; Region: DHH; pfam01368
502558007007	DHHA2 domain; Region: DHHA2; pfam02833
502558007008	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
502558007009	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
502558007010	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
502558007011	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
502558007012	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
502558007013	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558007014	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558007015	DNA binding residues [nucleotide binding]
502558007016	dimerization interface [polypeptide binding]; other site
502558007017	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558007018	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
502558007019	Part of AAA domain; Region: AAA_19; pfam13245
502558007020	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
502558007021	Family description; Region: UvrD_C_2; pfam13538
502558007022	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
502558007023	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
502558007024	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
502558007025	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
502558007026	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
502558007027	Chorismate mutase type II; Region: CM_2; smart00830
502558007028	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
502558007029	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558007030	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558007031	DNA binding residues [nucleotide binding]
502558007032	dimerization interface [polypeptide binding]; other site
502558007033	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
502558007034	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
502558007035	4Fe-4S binding domain; Region: Fer4; pfam00037
502558007036	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
502558007037	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558007038	molybdopterin cofactor binding site; other site
502558007039	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
502558007040	molybdopterin cofactor binding site; other site
502558007041	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
502558007042	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
502558007043	FAD binding domain; Region: FAD_binding_4; pfam01565
502558007044	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
502558007045	Cysteine-rich domain; Region: CCG; pfam02754
502558007046	Cysteine-rich domain; Region: CCG; pfam02754
502558007047	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
502558007048	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
502558007049	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
502558007050	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
502558007051	putative [4Fe-4S] binding site [ion binding]; other site
502558007052	putative molybdopterin cofactor binding site [chemical binding]; other site
502558007053	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
502558007054	molybdopterin cofactor binding site; other site
502558007055	Uncharacterized ArCR, COG2043; Region: DUF169; cl00894
502558007056	GMP synthase; Reviewed; Region: guaA; PRK00074
502558007057	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
502558007058	AMP/PPi binding site [chemical binding]; other site
502558007059	candidate oxyanion hole; other site
502558007060	catalytic triad [active]
502558007061	potential glutamine specificity residues [chemical binding]; other site
502558007062	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
502558007063	ATP Binding subdomain [chemical binding]; other site
502558007064	Ligand Binding sites [chemical binding]; other site
502558007065	Dimerization subdomain; other site
502558007066	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
502558007067	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
502558007068	active site
502558007069	GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439
502558007070	GIY-YIG motif/motif A; other site
502558007071	putative active site [active]
502558007072	putative metal binding site [ion binding]; other site
502558007073	AAA domain; Region: AAA_30; pfam13604
502558007074	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
502558007075	Uncharacterized conserved protein [Function unknown]; Region: COG3410
502558007076	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
502558007077	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
502558007078	putative NAD(P) binding site [chemical binding]; other site
502558007079	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
502558007080	tRNA-modifying enzyme; Provisional; Region: PRK13762
502558007081	YcfA-like protein; Region: YcfA; pfam07927
502558007082	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
502558007083	Post-segregation antitoxin CcdA; Region: CcdA; cl02188
502558007084	YjcQ protein; Region: YjcQ; pfam09639
502558007085	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
502558007086	HipA-like C-terminal domain; Region: HipA_C; pfam07804
502558007087	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
502558007088	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
502558007089	CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09644
502558007090	CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866
502558007091	tetramer interface [polypeptide binding]; other site
502558007092	putative DNA binding site [nucleotide binding]; other site
502558007093	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
502558007094	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
502558007095	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
502558007096	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
502558007097	TfoX C-terminal domain; Region: TfoX_C; pfam04994
502558007098	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
502558007099	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
502558007100	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
502558007101	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
502558007102	Part of AAA domain; Region: AAA_19; pfam13245
502558007103	Family description; Region: UvrD_C_2; pfam13538
502558007104	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
502558007105	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558007106	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
502558007107	Predicted membrane protein [Function unknown]; Region: COG2860
502558007108	UPF0126 domain; Region: UPF0126; pfam03458
502558007109	UPF0126 domain; Region: UPF0126; pfam03458
502558007110	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
502558007111	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
502558007112	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
502558007113	Phosphate transporter family; Region: PHO4; pfam01384
502558007114	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
502558007115	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558007116	putative substrate translocation pore; other site
502558007117	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
502558007118	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
502558007119	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
502558007120	Zn2+ binding site [ion binding]; other site
502558007121	Mg2+ binding site [ion binding]; other site
502558007122	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
502558007123	synthetase active site [active]
502558007124	NTP binding site [chemical binding]; other site
502558007125	metal binding site [ion binding]; metal-binding site
502558007126	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
502558007127	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
502558007128	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
502558007129	DHH family; Region: DHH; pfam01368
502558007130	DHHA1 domain; Region: DHHA1; pfam02272
502558007131	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
502558007132	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
502558007133	ATP binding site [chemical binding]; other site
502558007134	putative Mg++ binding site [ion binding]; other site
502558007135	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
502558007136	nucleotide binding region [chemical binding]; other site
502558007137	ATP-binding site [chemical binding]; other site
502558007138	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
502558007139	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
502558007140	putative oxidoreductase; Provisional; Region: PRK12831
502558007141	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
502558007142	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
502558007143	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
502558007144	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
502558007145	FAD binding pocket [chemical binding]; other site
502558007146	FAD binding motif [chemical binding]; other site
502558007147	phosphate binding motif [ion binding]; other site
502558007148	beta-alpha-beta structure motif; other site
502558007149	NAD binding pocket [chemical binding]; other site
502558007150	Iron coordination center [ion binding]; other site
502558007151	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u1; cd12826
502558007152	Cl binding site [ion binding]; other site
502558007153	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
502558007154	oligomer interface [polypeptide binding]; other site
502558007155	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
502558007156	Fe-S cluster binding site [ion binding]; other site
502558007157	active site
502558007158	alanine racemase; Reviewed; Region: alr; PRK00053
502558007159	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
502558007160	active site
502558007161	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
502558007162	dimer interface [polypeptide binding]; other site
502558007163	substrate binding site [chemical binding]; other site
502558007164	catalytic residues [active]
502558007165	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
502558007166	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558007167	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558007168	DNA binding residues [nucleotide binding]
502558007169	dimerization interface [polypeptide binding]; other site
502558007170	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
502558007171	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558007172	molybdopterin cofactor binding site; other site
502558007173	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
502558007174	molybdopterin cofactor binding site; other site
502558007175	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
502558007176	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
502558007177	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
502558007178	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
502558007179	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
502558007180	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
502558007181	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
502558007182	MPT binding site; other site
502558007183	trimer interface [polypeptide binding]; other site
502558007184	carotene isomerase; Region: carot_isom; TIGR02730
502558007185	enolase; Provisional; Region: eno; PRK00077
502558007186	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
502558007187	dimer interface [polypeptide binding]; other site
502558007188	metal binding site [ion binding]; metal-binding site
502558007189	substrate binding pocket [chemical binding]; other site
502558007190	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
502558007191	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
502558007192	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
502558007193	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
502558007194	alphaNTD - beta interaction site [polypeptide binding]; other site
502558007195	alphaNTD homodimer interface [polypeptide binding]; other site
502558007196	alphaNTD - beta' interaction site [polypeptide binding]; other site
502558007197	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
502558007198	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
502558007199	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
502558007200	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
502558007201	RNA binding surface [nucleotide binding]; other site
502558007202	30S ribosomal protein S11; Validated; Region: PRK05309
502558007203	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
502558007204	30S ribosomal protein S13; Region: bact_S13; TIGR03631
502558007205	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
502558007206	rRNA binding site [nucleotide binding]; other site
502558007207	predicted 30S ribosome binding site; other site
502558007208	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
502558007209	Ligand Binding Site [chemical binding]; other site
502558007210	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558007211	Major Facilitator Superfamily; Region: MFS_1; pfam07690
502558007212	putative substrate translocation pore; other site
502558007213	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
502558007214	Protein of unknown function (DUF2899); Region: DUF2899; pfam11449
502558007215	Protein of unknown function (DUF2899); Region: DUF2899; pfam11449
502558007216	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558007217	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558007218	non-specific DNA binding site [nucleotide binding]; other site
502558007219	salt bridge; other site
502558007220	sequence-specific DNA binding site [nucleotide binding]; other site
502558007221	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
502558007222	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558007223	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558007224	DNA binding residues [nucleotide binding]
502558007225	dimerization interface [polypeptide binding]; other site
502558007226	hypothetical protein; Validated; Region: PRK07121
502558007227	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558007228	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
502558007229	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
502558007230	ring oligomerisation interface [polypeptide binding]; other site
502558007231	ATP/Mg binding site [chemical binding]; other site
502558007232	stacking interactions; other site
502558007233	hinge regions; other site
502558007234	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
502558007235	oligomerisation interface [polypeptide binding]; other site
502558007236	mobile loop; other site
502558007237	roof hairpin; other site
502558007238	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558007239	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558007240	active site
502558007241	phosphorylation site [posttranslational modification]
502558007242	intermolecular recognition site; other site
502558007243	dimerization interface [polypeptide binding]; other site
502558007244	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558007245	DNA binding residues [nucleotide binding]
502558007246	dimerization interface [polypeptide binding]; other site
502558007247	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
502558007248	Histidine kinase; Region: HisKA_3; pfam07730
502558007249	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558007250	ATP binding site [chemical binding]; other site
502558007251	Mg2+ binding site [ion binding]; other site
502558007252	G-X-G motif; other site
502558007253	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558007254	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558007255	DNA binding residues [nucleotide binding]
502558007256	dimerization interface [polypeptide binding]; other site
502558007257	hypothetical protein; Validated; Region: PRK07121
502558007258	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558007259	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558007260	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558007261	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
502558007262	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
502558007263	homodimer interface [polypeptide binding]; other site
502558007264	NAD binding pocket [chemical binding]; other site
502558007265	ATP binding pocket [chemical binding]; other site
502558007266	Mg binding site [ion binding]; other site
502558007267	active-site loop [active]
502558007268	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
502558007269	hydroxyglutarate oxidase; Provisional; Region: PRK11728
502558007270	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558007271	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558007272	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558007273	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558007274	DNA binding residues [nucleotide binding]
502558007275	dimerization interface [polypeptide binding]; other site
502558007276	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
502558007277	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
502558007278	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
502558007279	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
502558007280	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
502558007281	active site
502558007282	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
502558007283	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
502558007284	S-adenosylmethionine binding site [chemical binding]; other site
502558007285	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
502558007286	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
502558007287	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
502558007288	shikimate binding site; other site
502558007289	NAD(P) binding site [chemical binding]; other site
502558007290	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
502558007291	HicB family; Region: HicB; pfam05534
502558007292	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
502558007293	Glycoprotease family; Region: Peptidase_M22; pfam00814
502558007294	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
502558007295	UGMP family protein; Validated; Region: PRK09604
502558007296	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
502558007297	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
502558007298	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
502558007299	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
502558007300	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
502558007301	active site
502558007302	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
502558007303	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
502558007304	Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Region: THF_DHG_CYH_C; pfam02882
502558007305	NAD(P) binding pocket [chemical binding]; other site
502558007306	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
502558007307	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
502558007308	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
502558007309	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
502558007310	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
502558007311	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
502558007312	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558007313	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558007314	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
502558007315	dimerization interface [polypeptide binding]; other site
502558007316	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558007317	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
502558007318	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
502558007319	active site
502558007320	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
502558007321	Domain of unknown function DUF21; Region: DUF21; pfam01595
502558007322	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
502558007323	Transporter associated domain; Region: CorC_HlyC; smart01091
502558007324	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558007325	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558007326	DNA binding residues [nucleotide binding]
502558007327	dimerization interface [polypeptide binding]; other site
502558007328	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558007329	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558007330	xanthine permease; Region: pbuX; TIGR03173
502558007331	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
502558007332	active site
502558007333	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558007334	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558007335	metal binding site [ion binding]; metal-binding site
502558007336	active site
502558007337	I-site; other site
502558007338	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558007339	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558007340	metal binding site [ion binding]; metal-binding site
502558007341	active site
502558007342	I-site; other site
502558007343	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558007344	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558007345	metal binding site [ion binding]; metal-binding site
502558007346	active site
502558007347	I-site; other site
502558007348	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558007349	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558007350	metal binding site [ion binding]; metal-binding site
502558007351	active site
502558007352	I-site; other site
502558007353	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
502558007354	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
502558007355	S-adenosylmethionine binding site [chemical binding]; other site
502558007356	Omega Transcriptional Repressor; Region: Omega_Repress; pfam07764
502558007357	Bacterial epsilon antitoxin; Region: Epsilon_antitox; pfam08998
502558007358	AAA ATPase domain; Region: AAA_16; pfam13191
502558007359	Methyltransferase domain; Region: Methyltransf_23; pfam13489
502558007360	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
502558007361	S-adenosylmethionine binding site [chemical binding]; other site
502558007362	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
502558007363	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
502558007364	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
502558007365	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
502558007366	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
502558007367	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558007368	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558007369	acyl-activating enzyme (AAE) consensus motif; other site
502558007370	AMP binding site [chemical binding]; other site
502558007371	active site
502558007372	CoA binding site [chemical binding]; other site
502558007373	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
502558007374	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
502558007375	metal binding site [ion binding]; metal-binding site
502558007376	substrate binding pocket [chemical binding]; other site
502558007377	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
502558007378	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
502558007379	substrate binding site [chemical binding]; other site
502558007380	oxyanion hole (OAH) forming residues; other site
502558007381	trimer interface [polypeptide binding]; other site
502558007382	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
502558007383	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
502558007384	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
502558007385	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
502558007386	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
502558007387	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
502558007388	dimer interface [polypeptide binding]; other site
502558007389	tetramer interface [polypeptide binding]; other site
502558007390	PYR/PP interface [polypeptide binding]; other site
502558007391	TPP binding site [chemical binding]; other site
502558007392	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
502558007393	TPP-binding site; other site
502558007394	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
502558007395	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
502558007396	TIGR04076 family protein; Region: TIGR04076
502558007397	Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309
502558007398	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704
502558007399	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558007400	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558007401	DNA binding residues [nucleotide binding]
502558007402	dimerization interface [polypeptide binding]; other site
502558007403	FAD binding domain; Region: FAD_binding_2; pfam00890
502558007404	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558007405	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
502558007406	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
502558007407	hypothetical protein; Validated; Region: PRK07121
502558007408	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558007409	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558007410	DNA binding residues [nucleotide binding]
502558007411	dimerization interface [polypeptide binding]; other site
502558007412	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
502558007413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558007414	ATP binding site [chemical binding]; other site
502558007415	Mg2+ binding site [ion binding]; other site
502558007416	G-X-G motif; other site
502558007417	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
502558007418	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558007419	active site
502558007420	phosphorylation site [posttranslational modification]
502558007421	intermolecular recognition site; other site
502558007422	dimerization interface [polypeptide binding]; other site
502558007423	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
502558007424	DNA binding site [nucleotide binding]
502558007425	FAD binding domain; Region: FAD_binding_2; pfam00890
502558007426	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558007427	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
502558007428	homodecamer interface [polypeptide binding]; other site
502558007429	GTP cyclohydrolase I; Provisional; Region: PLN03044
502558007430	active site
502558007431	putative catalytic site residues [active]
502558007432	zinc binding site [ion binding]; other site
502558007433	GTP-CH-I/GFRP interaction surface; other site
502558007434	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558007435	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558007436	DNA binding residues [nucleotide binding]
502558007437	dimerization interface [polypeptide binding]; other site
502558007438	hypothetical protein; Validated; Region: PRK07121
502558007439	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558007440	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
502558007441	methionine sulfoxide reductase B; Provisional; Region: PRK00222
502558007442	SelR domain; Region: SelR; pfam01641
502558007443	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
502558007444	active site
502558007445	putative catalytic site [active]
502558007446	DNA binding site [nucleotide binding]
502558007447	putative phosphate binding site [ion binding]; other site
502558007448	metal binding site A [ion binding]; metal-binding site
502558007449	AP binding site [nucleotide binding]; other site
502558007450	metal binding site B [ion binding]; metal-binding site
502558007451	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
502558007452	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
502558007453	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
502558007454	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
502558007455	dimer interface [polypeptide binding]; other site
502558007456	phosphorylation site [posttranslational modification]
502558007457	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558007458	ATP binding site [chemical binding]; other site
502558007459	Mg2+ binding site [ion binding]; other site
502558007460	G-X-G motif; other site
502558007461	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
502558007462	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558007463	active site
502558007464	phosphorylation site [posttranslational modification]
502558007465	intermolecular recognition site; other site
502558007466	dimerization interface [polypeptide binding]; other site
502558007467	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
502558007468	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558007469	active site
502558007470	phosphorylation site [posttranslational modification]
502558007471	intermolecular recognition site; other site
502558007472	dimerization interface [polypeptide binding]; other site
502558007473	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
502558007474	Zn2+ binding site [ion binding]; other site
502558007475	Mg2+ binding site [ion binding]; other site
502558007476	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
502558007477	putative binding surface; other site
502558007478	active site
502558007479	4Fe-4S binding domain; Region: Fer4_5; pfam12801
502558007480	4Fe-4S binding domain; Region: Fer4_5; pfam12801
502558007481	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
502558007482	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
502558007483	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
502558007484	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
502558007485	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
502558007486	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
502558007487	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
502558007488	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
502558007489	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558007490	molybdopterin cofactor binding site; other site
502558007491	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
502558007492	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558007493	The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781
502558007494	putative molybdopterin cofactor binding site; other site
502558007495	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
502558007496	MarR family; Region: MarR_2; pfam12802
502558007497	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
502558007498	amino acid carrier protein; Region: agcS; TIGR00835
502558007499	shikimate kinase; Reviewed; Region: aroK; PRK00131
502558007500	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
502558007501	ADP binding site [chemical binding]; other site
502558007502	magnesium binding site [ion binding]; other site
502558007503	putative shikimate binding site; other site
502558007504	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
502558007505	CoA-transferase family III; Region: CoA_transf_3; pfam02515
502558007506	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
502558007507	Ligand binding site [chemical binding]; other site
502558007508	Electron transfer flavoprotein domain; Region: ETF; pfam01012
502558007509	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
502558007510	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
502558007511	Ligand binding site [chemical binding]; other site
502558007512	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
502558007513	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
502558007514	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
502558007515	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
502558007516	active site
502558007517	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558007518	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
502558007519	acyl-activating enzyme (AAE) consensus motif; other site
502558007520	AMP binding site [chemical binding]; other site
502558007521	active site
502558007522	CoA binding site [chemical binding]; other site
502558007523	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
502558007524	Na binding site [ion binding]; other site
502558007525	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
502558007526	CoA-transferase family III; Region: CoA_transf_3; pfam02515
502558007527	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
502558007528	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
502558007529	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
502558007530	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
502558007531	active site
502558007532	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
502558007533	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
502558007534	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
502558007535	EamA-like transporter family; Region: EamA; pfam00892
502558007536	EamA-like transporter family; Region: EamA; pfam00892
502558007537	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
502558007538	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
502558007539	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
502558007540	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
502558007541	nucleoside/Zn binding site; other site
502558007542	dimer interface [polypeptide binding]; other site
502558007543	catalytic motif [active]
502558007544	hypothetical protein; Validated; Region: PRK07121
502558007545	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558007546	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558007547	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558007548	DNA binding residues [nucleotide binding]
502558007549	dimerization interface [polypeptide binding]; other site
502558007550	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
502558007551	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
502558007552	putative substrate translocation pore; other site
502558007553	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
502558007554	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
502558007555	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
502558007556	molybdopterin cofactor binding site; other site
502558007557	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
502558007558	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
502558007559	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
502558007560	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
502558007561	MarR family; Region: MarR_2; pfam12802
502558007562	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113
502558007563	dimer interface [polypeptide binding]; other site
502558007564	Citrate synthase; Region: Citrate_synt; pfam00285
502558007565	active site
502558007566	citrylCoA binding site [chemical binding]; other site
502558007567	oxalacetate/citrate binding site [chemical binding]; other site
502558007568	coenzyme A binding site [chemical binding]; other site
502558007569	catalytic triad [active]
502558007570	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
502558007571	dimer interface [polypeptide binding]; other site
502558007572	conserved gate region; other site
502558007573	putative PBP binding loops; other site
502558007574	ABC-ATPase subunit interface; other site
502558007575	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
502558007576	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
502558007577	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
502558007578	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558007579	Walker A/P-loop; other site
502558007580	ATP binding site [chemical binding]; other site
502558007581	Q-loop/lid; other site
502558007582	ABC transporter signature motif; other site
502558007583	Walker B; other site
502558007584	D-loop; other site
502558007585	H-loop/switch region; other site
502558007586	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
502558007587	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
502558007588	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
502558007589	DNA binding residues [nucleotide binding]
502558007590	cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146
502558007591	hypothetical protein; Validated; Region: PRK07121
502558007592	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558007593	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558007594	sequence-specific DNA binding site [nucleotide binding]; other site
502558007595	salt bridge; other site
502558007596	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
502558007597	dimer interface [polypeptide binding]; other site
502558007598	phosphorylation site [posttranslational modification]
502558007599	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558007600	ATP binding site [chemical binding]; other site
502558007601	Mg2+ binding site [ion binding]; other site
502558007602	G-X-G motif; other site
502558007603	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
502558007604	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558007605	active site
502558007606	phosphorylation site [posttranslational modification]
502558007607	intermolecular recognition site; other site
502558007608	dimerization interface [polypeptide binding]; other site
502558007609	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
502558007610	DNA binding site [nucleotide binding]
502558007611	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
502558007612	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
502558007613	Walker A/P-loop; other site
502558007614	ATP binding site [chemical binding]; other site
502558007615	Q-loop/lid; other site
502558007616	ABC transporter signature motif; other site
502558007617	Walker B; other site
502558007618	D-loop; other site
502558007619	H-loop/switch region; other site
502558007620	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
502558007621	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
502558007622	dimer interface [polypeptide binding]; other site
502558007623	conserved gate region; other site
502558007624	putative PBP binding loops; other site
502558007625	ABC-ATPase subunit interface; other site
502558007626	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
502558007627	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
502558007628	dimer interface [polypeptide binding]; other site
502558007629	conserved gate region; other site
502558007630	putative PBP binding loops; other site
502558007631	ABC-ATPase subunit interface; other site
502558007632	PBP superfamily domain; Region: PBP_like_2; cl17296
502558007633	PBP superfamily domain; Region: PBP_like_2; cl17296
502558007634	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
502558007635	domain interaction interfaces [polypeptide binding]; other site
502558007636	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
502558007637	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
502558007638	domain interaction interfaces [polypeptide binding]; other site
502558007639	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
502558007640	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
502558007641	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
502558007642	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
502558007643	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
502558007644	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
502558007645	Walker A motif; other site
502558007646	ATP binding site [chemical binding]; other site
502558007647	Walker B motif; other site
502558007648	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
502558007649	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
502558007650	Mechanosensitive ion channel; Region: MS_channel; pfam00924
502558007651	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
502558007652	FeS/SAM binding site; other site
502558007653	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
502558007654	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
502558007655	ATP cone domain; Region: ATP-cone; pfam03477
502558007656	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
502558007657	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
502558007658	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
502558007659	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
502558007660	Carbon starvation protein CstA; Region: CstA; pfam02554
502558007661	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
502558007662	aldolase; Validated; Region: PRK06852
502558007663	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
502558007664	catalytic residue [active]
502558007665	TM2 domain; Region: TM2; pfam05154
502558007666	Uncharacterized conserved protein [Function unknown]; Region: COG0398
502558007667	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
502558007668	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
502558007669	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
502558007670	ATP-grasp domain; Region: ATP-grasp_4; cl17255
502558007671	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
502558007672	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
502558007673	pyridoxal 5'-phosphate binding site [chemical binding]; other site
502558007674	homodimer interface [polypeptide binding]; other site
502558007675	catalytic residue [active]
502558007676	cyanophycin synthetase; Provisional; Region: PRK14016
502558007677	seryl-tRNA synthetase; Provisional; Region: PRK05431
502558007678	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
502558007679	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
502558007680	dimer interface [polypeptide binding]; other site
502558007681	active site
502558007682	motif 1; other site
502558007683	motif 2; other site
502558007684	motif 3; other site
502558007685	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
502558007686	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
502558007687	dimer interface [polypeptide binding]; other site
502558007688	phosphorylation site [posttranslational modification]
502558007689	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558007690	ATP binding site [chemical binding]; other site
502558007691	Mg2+ binding site [ion binding]; other site
502558007692	G-X-G motif; other site
502558007693	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
502558007694	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
502558007695	active site
502558007696	phosphorylation site [posttranslational modification]
502558007697	intermolecular recognition site; other site
502558007698	dimerization interface [polypeptide binding]; other site
502558007699	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
502558007700	dimer interface [polypeptide binding]; other site
502558007701	pyridoxal binding site [chemical binding]; other site
502558007702	ATP binding site [chemical binding]; other site
502558007703	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558007704	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558007705	DNA binding residues [nucleotide binding]
502558007706	dimerization interface [polypeptide binding]; other site
502558007707	hypothetical protein; Validated; Region: PRK07121
502558007708	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
502558007709	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
502558007710	active site
502558007711	ATP binding site [chemical binding]; other site
502558007712	substrate binding site [chemical binding]; other site
502558007713	activation loop (A-loop); other site
502558007714	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
502558007715	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
502558007716	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558007717	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558007718	metal binding site [ion binding]; metal-binding site
502558007719	active site
502558007720	I-site; other site
502558007721	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
502558007722	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
502558007723	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558007724	metal binding site [ion binding]; metal-binding site
502558007725	active site
502558007726	I-site; other site
502558007727	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
502558007728	metal binding site [ion binding]; metal-binding site
502558007729	active site
502558007730	I-site; other site
502558007731	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
502558007732	CAAX protease self-immunity; Region: Abi; pfam02517
502558007733	TraX protein; Region: TraX; pfam05857
502558007734	Transcriptional regulator [Transcription]; Region: LytR; COG1316
502558007735	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
502558007736	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
502558007737	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
502558007738	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
502558007739	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
502558007740	catalytic triad [active]
502558007741	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
502558007742	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
502558007743	transmembrane helices; other site
502558007744	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
502558007745	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558007746	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558007747	DNA binding residues [nucleotide binding]
502558007748	dimerization interface [polypeptide binding]; other site
502558007749	Fic family protein [Function unknown]; Region: COG3177
502558007750	Fic/DOC family; Region: Fic; pfam02661
502558007751	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
502558007752	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
502558007753	active site
502558007754	DNA binding site [nucleotide binding]
502558007755	Int/Topo IB signature motif; other site
502558007756	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
502558007757	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
502558007758	Walker A motif; other site
502558007759	ATP binding site [chemical binding]; other site
502558007760	Walker B motif; other site
502558007761	AAA-like domain; Region: AAA_10; pfam12846
502558007762	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
502558007763	Walker A motif; other site
502558007764	ATP binding site [chemical binding]; other site
502558007765	Walker B motif; other site
502558007766	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
502558007767	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558007768	non-specific DNA binding site [nucleotide binding]; other site
502558007769	salt bridge; other site
502558007770	sequence-specific DNA binding site [nucleotide binding]; other site
502558007771	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558007772	non-specific DNA binding site [nucleotide binding]; other site
502558007773	salt bridge; other site
502558007774	sequence-specific DNA binding site [nucleotide binding]; other site
502558007775	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
502558007776	Ligand Binding Site [chemical binding]; other site
502558007777	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
502558007778	dinuclear metal binding motif [ion binding]; other site
502558007779	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
502558007780	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
502558007781	ABC1 family; Region: ABC1; cl17513
502558007782	hypothetical protein; Validated; Region: PRK07121
502558007783	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558007784	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558007785	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558007786	DNA binding residues [nucleotide binding]
502558007787	dimerization interface [polypeptide binding]; other site
502558007788	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
502558007789	EamA-like transporter family; Region: EamA; pfam00892
502558007790	EamA-like transporter family; Region: EamA; pfam00892
502558007791	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
502558007792	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
502558007793	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
502558007794	phosphopeptide binding site; other site
502558007795	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
502558007796	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
502558007797	phosphopeptide binding site; other site
502558007798	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
502558007799	Protein phosphatase 2C; Region: PP2C; pfam00481
502558007800	active site
502558007801	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
502558007802	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
502558007803	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
502558007804	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
502558007805	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
502558007806	active site
502558007807	ATP binding site [chemical binding]; other site
502558007808	substrate binding site [chemical binding]; other site
502558007809	activation loop (A-loop); other site
502558007810	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
502558007811	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
502558007812	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
502558007813	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
502558007814	Histidine kinase; Region: His_kinase; pfam06580
502558007815	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
502558007816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558007817	ATP binding site [chemical binding]; other site
502558007818	Mg2+ binding site [ion binding]; other site
502558007819	G-X-G motif; other site
502558007820	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
502558007821	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
502558007822	QueT transporter; Region: QueT; pfam06177
502558007823	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
502558007824	Predicted GTPases [General function prediction only]; Region: COG1162
502558007825	RNA binding site [nucleotide binding]; other site
502558007826	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
502558007827	GTPase/Zn-binding domain interface [polypeptide binding]; other site
502558007828	GTP/Mg2+ binding site [chemical binding]; other site
502558007829	G4 box; other site
502558007830	G5 box; other site
502558007831	G1 box; other site
502558007832	Switch I region; other site
502558007833	G2 box; other site
502558007834	G3 box; other site
502558007835	Switch II region; other site
502558007836	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
502558007837	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
502558007838	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
502558007839	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
502558007840	FMN binding site [chemical binding]; other site
502558007841	substrate binding site [chemical binding]; other site
502558007842	putative catalytic residue [active]
502558007843	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
502558007844	Clp amino terminal domain; Region: Clp_N; pfam02861
502558007845	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558007846	Walker A motif; other site
502558007847	ATP binding site [chemical binding]; other site
502558007848	Walker B motif; other site
502558007849	arginine finger; other site
502558007850	Protein of unknown function (DUF1664); Region: DUF1664; pfam07889
502558007851	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
502558007852	Walker A motif; other site
502558007853	ATP binding site [chemical binding]; other site
502558007854	Walker B motif; other site
502558007855	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
502558007856	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
502558007857	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
502558007858	DNA binding residues [nucleotide binding]
502558007859	chaperone protein DnaJ; Provisional; Region: PRK14294
502558007860	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
502558007861	HSP70 interaction site [polypeptide binding]; other site
502558007862	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
502558007863	substrate binding site [polypeptide binding]; other site
502558007864	dimer interface [polypeptide binding]; other site
502558007865	GrpE; Region: GrpE; pfam01025
502558007866	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
502558007867	dimer interface [polypeptide binding]; other site
502558007868	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
502558007869	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
502558007870	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
502558007871	nucleotide binding site [chemical binding]; other site
502558007872	NEF interaction site [polypeptide binding]; other site
502558007873	SBD interface [polypeptide binding]; other site
502558007874	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
502558007875	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
502558007876	dimerization interface [polypeptide binding]; other site
502558007877	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
502558007878	ATP binding site [chemical binding]; other site
502558007879	nickel responsive regulator; Provisional; Region: PRK04460
502558007880	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
502558007881	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
502558007882	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
502558007883	Transcriptional regulator [Transcription]; Region: LysR; COG0583
502558007884	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
502558007885	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
502558007886	dimerization interface [polypeptide binding]; other site
502558007887	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
502558007888	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
502558007889	active site
502558007890	substrate binding site [chemical binding]; other site
502558007891	metal binding site [ion binding]; metal-binding site
502558007892	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
502558007893	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
502558007894	DNA binding residues [nucleotide binding]
502558007895	dimerization interface [polypeptide binding]; other site
502558007896	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
502558007897	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
502558007898	Predicted oxidoreductase [General function prediction only]; Region: COG3573
502558007899	UDP-glucose 4-epimerase; Region: PLN02240
502558007900	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
502558007901	NAD binding site [chemical binding]; other site
502558007902	homodimer interface [polypeptide binding]; other site
502558007903	active site
502558007904	substrate binding site [chemical binding]; other site
502558007905	Transcriptional regulator [Transcription]; Region: LytR; COG1316
502558007906	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558007907	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558007908	non-specific DNA binding site [nucleotide binding]; other site
502558007909	salt bridge; other site
502558007910	sequence-specific DNA binding site [nucleotide binding]; other site
502558007911	Predicted integral membrane protein [Function unknown]; Region: COG5652
502558007912	phosphoglycolate phosphatase; Provisional; Region: PRK13222
502558007913	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
502558007914	motif II; other site
502558007915	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
502558007916	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
502558007917	active site
502558007918	DNA binding site [nucleotide binding]
502558007919	Int/Topo IB signature motif; other site
502558007920	Helix-turn-helix domain; Region: HTH_17; pfam12728
502558007921	PemK-like protein; Region: PemK; pfam02452
502558007922	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
502558007923	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
502558007924	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
502558007925	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
502558007926	homotetramer interface [polypeptide binding]; other site
502558007927	ligand binding site [chemical binding]; other site
502558007928	catalytic site [active]
502558007929	NAD binding site [chemical binding]; other site
502558007930	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
502558007931	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
502558007932	dimer interface [polypeptide binding]; other site
502558007933	pyridoxal 5'-phosphate binding site [chemical binding]; other site
502558007934	catalytic residue [active]
502558007935	S-adenosylmethionine synthetase; Validated; Region: PRK05250
502558007936	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
502558007937	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
502558007938	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
502558007939	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
502558007940	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
502558007941	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
502558007942	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
502558007943	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
502558007944	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558007945	Walker A/P-loop; other site
502558007946	ATP binding site [chemical binding]; other site
502558007947	Q-loop/lid; other site
502558007948	ABC transporter signature motif; other site
502558007949	Walker B; other site
502558007950	D-loop; other site
502558007951	H-loop/switch region; other site
502558007952	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
502558007953	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
502558007954	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
502558007955	Walker A/P-loop; other site
502558007956	ATP binding site [chemical binding]; other site
502558007957	Q-loop/lid; other site
502558007958	ABC transporter signature motif; other site
502558007959	Walker B; other site
502558007960	D-loop; other site
502558007961	H-loop/switch region; other site
502558007962	tetracycline repressor protein TetR; Provisional; Region: PRK13756
502558007963	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558007964	CoA binding site [chemical binding]; other site
502558007965	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
502558007966	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
502558007967	acyl-activating enzyme (AAE) consensus motif; other site
502558007968	AMP binding site [chemical binding]; other site
502558007969	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
502558007970	Condensation domain; Region: Condensation; pfam00668
502558007971	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
502558007972	Nonribosomal peptide synthase; Region: NRPS; pfam08415
502558007973	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
502558007974	acyl-activating enzyme (AAE) consensus motif; other site
502558007975	AMP binding site [chemical binding]; other site
502558007976	Methyltransferase domain; Region: Methyltransf_31; pfam13847
502558007977	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
502558007978	S-adenosylmethionine binding site [chemical binding]; other site
502558007979	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
502558007980	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
502558007981	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
502558007982	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
502558007983	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
502558007984	thiazolinyl imide reductase; Region: thiaz-red; TIGR01761
502558007985	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
502558007986	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
502558007987	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
502558007988	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
502558007989	Walker A/P-loop; other site
502558007990	ATP binding site [chemical binding]; other site
502558007991	Q-loop/lid; other site
502558007992	ABC transporter signature motif; other site
502558007993	Walker B; other site
502558007994	D-loop; other site
502558007995	H-loop/switch region; other site
502558007996	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
502558007997	Walker A/P-loop; other site
502558007998	ATP binding site [chemical binding]; other site
502558007999	Q-loop/lid; other site
502558008000	ABC transporter signature motif; other site
502558008001	Walker B; other site
502558008002	D-loop; other site
502558008003	H-loop/switch region; other site
502558008004	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
502558008005	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
502558008006	putative PBP binding loops; other site
502558008007	dimer interface [polypeptide binding]; other site
502558008008	ABC-ATPase subunit interface; other site
502558008009	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
502558008010	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
502558008011	dimer interface [polypeptide binding]; other site
502558008012	conserved gate region; other site
502558008013	putative PBP binding loops; other site
502558008014	ABC-ATPase subunit interface; other site
502558008015	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
502558008016	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
502558008017	CHAP domain; Region: CHAP; cl17642
502558008018	AAA-like domain; Region: AAA_10; pfam12846
502558008019	Domain of unknown function DUF87; Region: DUF87; pfam01935
502558008020	PrgI family protein; Region: PrgI; pfam12666
502558008021	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
502558008022	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
502558008023	Walker A motif; other site
502558008024	ATP binding site [chemical binding]; other site
502558008025	Walker B motif; other site
502558008026	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
502558008027	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
502558008028	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
502558008029	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
502558008030	Toprim-like; Region: Toprim_2; pfam13155
502558008031	Abi-like protein; Region: Abi_2; pfam07751
502558008032	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
502558008033	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
502558008034	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
502558008035	cofactor binding site; other site
502558008036	DNA binding site [nucleotide binding]
502558008037	substrate interaction site [chemical binding]; other site
502558008038	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
502558008039	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442
502558008040	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
502558008041	cofactor binding site; other site
502558008042	DNA binding site [nucleotide binding]
502558008043	substrate interaction site [chemical binding]; other site
502558008044	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
502558008045	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
502558008046	S-adenosylmethionine binding site [chemical binding]; other site
502558008047	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
502558008048	DEAD-like helicases superfamily; Region: DEXDc; smart00487
502558008049	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
502558008050	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
502558008051	helicase superfamily c-terminal domain; Region: HELICc; smart00490
502558008052	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
502558008053	NlpC/P60 family; Region: NLPC_P60; cl17555
502558008054	Cna protein B-type domain; Region: Cna_B; pfam05738
502558008055	Cna protein B-type domain; Region: Cna_B; pfam05738
502558008056	Cna protein B-type domain; Region: Cna_B; pfam05738
502558008057	Cna protein B-type domain; Region: Cna_B; pfam05738
502558008058	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
502558008059	active site
502558008060	catalytic site [active]
502558008061	ParB-like nuclease domain; Region: ParBc; pfam02195
502558008062	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
502558008063	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
502558008064	P-loop; other site
502558008065	Magnesium ion binding site [ion binding]; other site
502558008066	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
502558008067	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
502558008068	Magnesium ion binding site [ion binding]; other site
502558008069	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
502558008070	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
502558008071	non-specific DNA binding site [nucleotide binding]; other site
502558008072	salt bridge; other site
502558008073	sequence-specific DNA binding site [nucleotide binding]; other site
502558008074	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
502558008075	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
502558008076	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
502558008077	Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906
502558008078	putative ADP-ribose binding site [chemical binding]; other site
502558008079	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
502558008080	DNA binding residues [nucleotide binding]
502558008081	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
502558008082	drug binding residues [chemical binding]; other site
502558008083	dimer interface [polypeptide binding]; other site
502558008084	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
502558008085	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
502558008086	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
502558008087	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
502558008088	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
502558008089	Walker A/P-loop; other site
502558008090	ATP binding site [chemical binding]; other site
502558008091	Q-loop/lid; other site
502558008092	ABC transporter signature motif; other site
502558008093	Walker B; other site
502558008094	D-loop; other site
502558008095	H-loop/switch region; other site
502558008096	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
502558008097	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
502558008098	DNA binding residues [nucleotide binding]
502558008099	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
502558008100	DNA binding residues [nucleotide binding]
502558008101	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
502558008102	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
502558008103	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
502558008104	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
502558008105	Walker A/P-loop; other site
502558008106	ATP binding site [chemical binding]; other site
502558008107	Q-loop/lid; other site
502558008108	ABC transporter signature motif; other site
502558008109	Walker B; other site
502558008110	D-loop; other site
502558008111	H-loop/switch region; other site
502558008112	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
502558008113	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
502558008114	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
502558008115	DNA binding residues [nucleotide binding]
502558008116	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
502558008117	metal binding site [ion binding]; metal-binding site
502558008118	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
502558008119	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
502558008120	active site
502558008121	catalytic site [active]
502558008122	substrate binding site [chemical binding]; other site
502558008123	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
502558008124	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
502558008125	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
502558008126	ATP-grasp domain; Region: ATP-grasp_4; cl17255
502558008127	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
502558008128	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
502558008129	FeS/SAM binding site; other site
502558008130	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
502558008131	ParB-like nuclease domain; Region: ParBc; pfam02195
502558008132	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
502558008133	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
502558008134	P-loop; other site
502558008135	Magnesium ion binding site [ion binding]; other site
502558008136	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
502558008137	Magnesium ion binding site [ion binding]; other site
502558008138	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
502558008139	putative active site [active]
502558008140	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
502558008141	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
502558008142	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
502558008143	G-X-X-G motif; other site
502558008144	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
502558008145	RxxxH motif; other site
502558008146	60Kd inner membrane protein; Region: 60KD_IMP; pfam02096
502558008147	Ribonuclease P; Region: Ribonuclease_P; pfam00825
502558008148	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
502558008149	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
502558008150	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
502558008151	ATP binding site [chemical binding]; other site
502558008152	Mg2+ binding site [ion binding]; other site
502558008153	G-X-G motif; other site
502558008154	Transcriptional regulators [Transcription]; Region: MarR; COG1846
502558008155	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
502558008156	dimerization interface [polypeptide binding]; other site
502558008157	putative Zn2+ binding site [ion binding]; other site
502558008158	putative DNA binding site [nucleotide binding]; other site