-- dump date 20140619_070331 -- class Genbank::misc_feature -- table misc_feature_note -- id note 269484000001 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 269484000002 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 269484000003 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 269484000004 motif 1; other site 269484000005 dimer interface [polypeptide binding]; other site 269484000006 active site 269484000007 motif 2; other site 269484000008 motif 3; other site 269484000009 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 269484000010 chaperone protein DnaJ; Provisional; Region: PRK10767 269484000011 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 269484000012 HSP70 interaction site [polypeptide binding]; other site 269484000013 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 269484000014 substrate binding site [polypeptide binding]; other site 269484000015 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 269484000016 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 269484000017 dimer interface [polypeptide binding]; other site 269484000018 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 269484000019 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 269484000020 dimerization interface [polypeptide binding]; other site 269484000021 active site 269484000022 membrane protein; Provisional; Region: PRK14394 269484000023 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 269484000024 active site 269484000025 putative DNA-binding cleft [nucleotide binding]; other site 269484000026 dimer interface [polypeptide binding]; other site 269484000027 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 269484000028 Subunit III/VIIa interface [polypeptide binding]; other site 269484000029 Phospholipid binding site [chemical binding]; other site 269484000030 Subunit I/III interface [polypeptide binding]; other site 269484000031 Subunit III/VIb interface [polypeptide binding]; other site 269484000032 Subunit III/VIa interface; other site 269484000033 Subunit III/Vb interface [polypeptide binding]; other site 269484000034 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 269484000035 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 269484000036 substrate binding site [chemical binding]; other site 269484000037 active site 269484000038 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 269484000039 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 269484000040 Transporter associated domain; Region: CorC_HlyC; smart01091 269484000041 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 269484000042 Phage-related protein [Function unknown]; Region: COG4695 269484000043 Phage portal protein; Region: Phage_portal; pfam04860 269484000044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269484000045 S-adenosylmethionine binding site [chemical binding]; other site 269484000046 quinolinate synthetase; Provisional; Region: PRK09375 269484000047 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 269484000048 4Fe-4S binding domain; Region: Fer4; cl02805 269484000049 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 269484000050 Ehrlichia tandem repeat (Ehrlichia_rpt); Region: Ehrlichia_rpt; pfam09528 269484000051 type IV secretion system component VirD4; Provisional; Region: PRK13897 269484000052 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 269484000053 Walker A motif; other site 269484000054 ATP binding site [chemical binding]; other site 269484000055 Walker B motif; other site 269484000056 type IV secretion system ATPase VirB11; Provisional; Region: PRK13900 269484000057 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 269484000058 ATP binding site [chemical binding]; other site 269484000059 Walker A motif; other site 269484000060 hexamer interface [polypeptide binding]; other site 269484000061 Walker B motif; other site 269484000062 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 269484000063 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 269484000064 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 269484000065 VirB7 interaction site; other site 269484000066 VirB8 protein; Region: VirB8; pfam04335 269484000067 GTP cyclohydrolase; Provisional; Region: PRK08815 269484000068 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 269484000069 dimerization interface [polypeptide binding]; other site 269484000070 active site 269484000071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269484000072 binding surface 269484000073 Tetratricopeptide repeat; Region: TPR_16; pfam13432 269484000074 TPR motif; other site 269484000075 Methyltransferase domain; Region: Methyltransf_23; pfam13489 269484000076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269484000077 S-adenosylmethionine binding site [chemical binding]; other site 269484000078 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 269484000079 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 269484000080 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 269484000081 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 269484000082 Phosphoglycerate kinase; Region: PGK; pfam00162 269484000083 substrate binding site [chemical binding]; other site 269484000084 hinge regions; other site 269484000085 ADP binding site [chemical binding]; other site 269484000086 catalytic site [active] 269484000087 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 269484000088 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 269484000089 generic binding surface II; other site 269484000090 generic binding surface I; other site 269484000091 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 269484000092 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 269484000093 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 269484000094 trimer interface [polypeptide binding]; other site 269484000095 active site 269484000096 substrate binding site [chemical binding]; other site 269484000097 CoA binding site [chemical binding]; other site 269484000098 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 269484000099 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 269484000100 trmE is a tRNA modification GTPase; Region: trmE; cd04164 269484000101 G1 box; other site 269484000102 GTP/Mg2+ binding site [chemical binding]; other site 269484000103 Switch I region; other site 269484000104 G2 box; other site 269484000105 Switch II region; other site 269484000106 G3 box; other site 269484000107 G4 box; other site 269484000108 G5 box; other site 269484000109 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 269484000110 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 269484000111 Flavoprotein; Region: Flavoprotein; pfam02441 269484000112 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 269484000113 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 269484000114 generic binding surface II; other site 269484000115 ssDNA binding site; other site 269484000116 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269484000117 ATP binding site [chemical binding]; other site 269484000118 putative Mg++ binding site [ion binding]; other site 269484000119 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269484000120 nucleotide binding region [chemical binding]; other site 269484000121 ATP-binding site [chemical binding]; other site 269484000122 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 269484000123 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 269484000124 putative NAD(P) binding site [chemical binding]; other site 269484000125 active site 269484000126 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 269484000127 CcmB protein; Region: CcmB; cl17444 269484000128 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 269484000129 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 269484000130 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 269484000131 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 269484000132 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 269484000133 putative acyl-acceptor binding pocket; other site 269484000134 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 269484000135 active site 269484000136 catalytic residues [active] 269484000137 metal binding site [ion binding]; metal-binding site 269484000138 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 269484000139 Fe-S cluster binding site [ion binding]; other site 269484000140 active site 269484000141 recombination protein F; Reviewed; Region: recF; PRK00064 269484000142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269484000143 Walker A/P-loop; other site 269484000144 ATP binding site [chemical binding]; other site 269484000145 Q-loop/lid; other site 269484000146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269484000147 ABC transporter signature motif; other site 269484000148 Walker B; other site 269484000149 D-loop; other site 269484000150 H-loop/switch region; other site 269484000151 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 269484000152 ornithine carbamoyltransferase; Provisional; Region: PRK00779 269484000153 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 269484000154 DNA polymerase I; Provisional; Region: PRK05755 269484000155 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 269484000156 active site 269484000157 metal binding site 1 [ion binding]; metal-binding site 269484000158 putative 5' ssDNA interaction site; other site 269484000159 metal binding site 3; metal-binding site 269484000160 metal binding site 2 [ion binding]; metal-binding site 269484000161 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 269484000162 putative DNA binding site [nucleotide binding]; other site 269484000163 putative metal binding site [ion binding]; other site 269484000164 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 269484000165 active site 269484000166 catalytic site [active] 269484000167 substrate binding site [chemical binding]; other site 269484000168 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 269484000169 active site 269484000170 DNA binding site [nucleotide binding] 269484000171 catalytic site [active] 269484000172 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 269484000173 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 269484000174 substrate binding site [chemical binding]; other site 269484000175 hexamer interface [polypeptide binding]; other site 269484000176 metal binding site [ion binding]; metal-binding site 269484000177 Permease; Region: Permease; pfam02405 269484000178 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 269484000179 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 269484000180 Walker A/P-loop; other site 269484000181 ATP binding site [chemical binding]; other site 269484000182 Q-loop/lid; other site 269484000183 ABC transporter signature motif; other site 269484000184 Walker B; other site 269484000185 D-loop; other site 269484000186 H-loop/switch region; other site 269484000187 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269484000188 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 269484000189 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 269484000190 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 269484000191 substrate binding pocket [chemical binding]; other site 269484000192 chain length determination region; other site 269484000193 substrate-Mg2+ binding site; other site 269484000194 catalytic residues [active] 269484000195 aspartate-rich region 1; other site 269484000196 active site lid residues [active] 269484000197 aspartate-rich region 2; other site 269484000198 glutamine synthetase; Provisional; Region: glnA; PRK09469 269484000199 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 269484000200 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 269484000201 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 269484000202 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 269484000203 active site 269484000204 HIGH motif; other site 269484000205 dimer interface [polypeptide binding]; other site 269484000206 KMSKS motif; other site 269484000207 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 269484000208 RNA binding surface [nucleotide binding]; other site 269484000209 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 269484000210 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 269484000211 substrate-cofactor binding pocket; other site 269484000212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269484000213 catalytic residue [active] 269484000214 hypothetical protein; Provisional; Region: PRK14683 269484000215 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 269484000216 Protein export membrane protein; Region: SecD_SecF; pfam02355 269484000217 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 269484000218 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 269484000219 putative active site; other site 269484000220 catalytic residue [active] 269484000221 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 269484000222 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 269484000223 E3 interaction surface; other site 269484000224 lipoyl attachment site [posttranslational modification]; other site 269484000225 e3 binding domain; Region: E3_binding; pfam02817 269484000226 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 269484000227 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 269484000228 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 269484000229 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 269484000230 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 269484000231 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 269484000232 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 269484000233 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 269484000234 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 269484000235 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 269484000236 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 269484000237 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 269484000238 Protein of unknown function (DUF3514); Region: DUF3514; pfam12027 269484000239 GMP synthase; Reviewed; Region: guaA; PRK00074 269484000240 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 269484000241 AMP/PPi binding site [chemical binding]; other site 269484000242 candidate oxyanion hole; other site 269484000243 catalytic triad [active] 269484000244 potential glutamine specificity residues [chemical binding]; other site 269484000245 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 269484000246 ATP Binding subdomain [chemical binding]; other site 269484000247 Ligand Binding sites [chemical binding]; other site 269484000248 Dimerization subdomain; other site 269484000249 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 269484000250 Citrate synthase; Region: Citrate_synt; pfam00285 269484000251 oxalacetate binding site [chemical binding]; other site 269484000252 citrylCoA binding site [chemical binding]; other site 269484000253 coenzyme A binding site [chemical binding]; other site 269484000254 catalytic triad [active] 269484000255 Glutamate-cysteine ligase; Region: GshA; pfam08886 269484000256 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 269484000257 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 269484000258 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 269484000259 FtsX-like permease family; Region: FtsX; pfam02687 269484000260 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 269484000261 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 269484000262 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 269484000263 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 269484000264 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 269484000265 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 269484000266 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 269484000267 beta subunit interaction interface [polypeptide binding]; other site 269484000268 Walker A motif; other site 269484000269 ATP binding site [chemical binding]; other site 269484000270 Walker B motif; other site 269484000271 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 269484000272 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 269484000273 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 269484000274 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 269484000275 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 269484000276 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 269484000277 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 269484000278 SmpB-tmRNA interface; other site 269484000279 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 269484000280 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 269484000281 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 269484000282 active site 269484000283 HIGH motif; other site 269484000284 nucleotide binding site [chemical binding]; other site 269484000285 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 269484000286 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 269484000287 active site 269484000288 KMSKS motif; other site 269484000289 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 269484000290 tRNA binding surface [nucleotide binding]; other site 269484000291 anticodon binding site; other site 269484000292 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 269484000293 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 269484000294 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 269484000295 amidophosphoribosyltransferase; Provisional; Region: PRK09123 269484000296 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 269484000297 active site 269484000298 tetramer interface [polypeptide binding]; other site 269484000299 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269484000300 active site 269484000301 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 269484000302 putative active site [active] 269484000303 catalytic residue [active] 269484000304 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 269484000305 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 269484000306 5S rRNA interface [nucleotide binding]; other site 269484000307 CTC domain interface [polypeptide binding]; other site 269484000308 L16 interface [polypeptide binding]; other site 269484000309 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 269484000310 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269484000311 active site 269484000312 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 269484000313 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 269484000314 metal binding site [ion binding]; metal-binding site 269484000315 dimer interface [polypeptide binding]; other site 269484000316 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 269484000317 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 269484000318 TrkA-N domain; Region: TrkA_N; pfam02254 269484000319 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 269484000320 putative catalytic residue [active] 269484000321 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 269484000322 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 269484000323 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 269484000324 alpha subunit interface [polypeptide binding]; other site 269484000325 TPP binding site [chemical binding]; other site 269484000326 heterodimer interface [polypeptide binding]; other site 269484000327 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 269484000328 protease TldD; Provisional; Region: tldD; PRK10735 269484000329 GTP-binding protein YchF; Reviewed; Region: PRK09601 269484000330 YchF GTPase; Region: YchF; cd01900 269484000331 G1 box; other site 269484000332 GTP/Mg2+ binding site [chemical binding]; other site 269484000333 Switch I region; other site 269484000334 G2 box; other site 269484000335 Switch II region; other site 269484000336 G3 box; other site 269484000337 G4 box; other site 269484000338 G5 box; other site 269484000339 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 269484000340 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 269484000341 homotrimer interaction site [polypeptide binding]; other site 269484000342 zinc binding site [ion binding]; other site 269484000343 CDP-binding sites; other site 269484000344 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 269484000345 substrate binding site; other site 269484000346 dimer interface; other site 269484000347 AIR carboxylase; Region: AIRC; pfam00731 269484000348 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 269484000349 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 269484000350 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 269484000351 IHF - DNA interface [nucleotide binding]; other site 269484000352 IHF dimer interface [polypeptide binding]; other site 269484000353 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 269484000354 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 269484000355 DNA binding residues [nucleotide binding] 269484000356 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 269484000357 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 269484000358 active site 269484000359 HIGH motif; other site 269484000360 dimer interface [polypeptide binding]; other site 269484000361 KMSKS motif; other site 269484000362 GrpE; Region: GrpE; pfam01025 269484000363 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 269484000364 dimer interface [polypeptide binding]; other site 269484000365 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 269484000366 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 269484000367 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 269484000368 catalytic motif [active] 269484000369 Zn binding site [ion binding]; other site 269484000370 RibD C-terminal domain; Region: RibD_C; cl17279 269484000371 CTP synthetase; Validated; Region: pyrG; PRK05380 269484000372 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 269484000373 Catalytic site [active] 269484000374 active site 269484000375 UTP binding site [chemical binding]; other site 269484000376 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 269484000377 active site 269484000378 putative oxyanion hole; other site 269484000379 catalytic triad [active] 269484000380 protein translocase, SecG subunit; Region: secG; TIGR00810 269484000381 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 269484000382 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 269484000383 active site 269484000384 DNA binding site [nucleotide binding] 269484000385 Int/Topo IB signature motif; other site 269484000386 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 269484000387 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 269484000388 Walker A/P-loop; other site 269484000389 ATP binding site [chemical binding]; other site 269484000390 Q-loop/lid; other site 269484000391 ABC transporter signature motif; other site 269484000392 Walker B; other site 269484000393 D-loop; other site 269484000394 H-loop/switch region; other site 269484000395 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 269484000396 Malic enzyme, N-terminal domain; Region: malic; pfam00390 269484000397 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 269484000398 putative NAD(P) binding site [chemical binding]; other site 269484000399 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 269484000400 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 269484000401 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 269484000402 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 269484000403 putative active site [active] 269484000404 catalytic triad [active] 269484000405 putative dimer interface [polypeptide binding]; other site 269484000406 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12662 269484000407 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269484000408 mce related protein; Region: MCE; pfam02470 269484000409 NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534 269484000410 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 269484000411 ATP cone domain; Region: ATP-cone; pfam03477 269484000412 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 269484000413 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 269484000414 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 269484000415 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 269484000416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269484000417 metabolite-proton symporter; Region: 2A0106; TIGR00883 269484000418 putative substrate translocation pore; other site 269484000419 Uncharacterized conserved protein [Function unknown]; Region: COG2835 269484000420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 269484000421 NAD(P) binding site [chemical binding]; other site 269484000422 active site 269484000423 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 269484000424 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 269484000425 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 269484000426 dimer interface [polypeptide binding]; other site 269484000427 motif 1; other site 269484000428 active site 269484000429 motif 2; other site 269484000430 motif 3; other site 269484000431 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 269484000432 23S rRNA binding site [nucleotide binding]; other site 269484000433 L21 binding site [polypeptide binding]; other site 269484000434 L13 binding site [polypeptide binding]; other site 269484000435 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 269484000436 Protein of unknown function (DUF1013); Region: DUF1013; pfam06242 269484000437 transcription termination factor Rho; Provisional; Region: rho; PRK09376 269484000438 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 269484000439 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 269484000440 RNA binding site [nucleotide binding]; other site 269484000441 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 269484000442 multimer interface [polypeptide binding]; other site 269484000443 Walker A motif; other site 269484000444 ATP binding site [chemical binding]; other site 269484000445 Walker B motif; other site 269484000446 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 269484000447 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 269484000448 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269484000449 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 269484000450 putative hydrolase; Provisional; Region: PRK02113 269484000451 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 269484000452 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 269484000453 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 269484000454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269484000455 dimer interface [polypeptide binding]; other site 269484000456 conserved gate region; other site 269484000457 putative PBP binding loops; other site 269484000458 ABC-ATPase subunit interface; other site 269484000459 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 269484000460 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 269484000461 motif 1; other site 269484000462 active site 269484000463 motif 2; other site 269484000464 motif 3; other site 269484000465 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 269484000466 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 269484000467 CoA binding domain; Region: CoA_binding; pfam02629 269484000468 CoA-ligase; Region: Ligase_CoA; pfam00549 269484000469 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 269484000470 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 269484000471 CoA-ligase; Region: Ligase_CoA; pfam00549 269484000472 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 269484000473 PBP superfamily domain; Region: PBP_like_2; cl17296 269484000474 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 269484000475 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 269484000476 Cu(I) binding site [ion binding]; other site 269484000477 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 269484000478 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 269484000479 FMN binding site [chemical binding]; other site 269484000480 substrate binding site [chemical binding]; other site 269484000481 putative catalytic residue [active] 269484000482 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 269484000483 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 269484000484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269484000485 dimer interface [polypeptide binding]; other site 269484000486 conserved gate region; other site 269484000487 putative PBP binding loops; other site 269484000488 ABC-ATPase subunit interface; other site 269484000489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 269484000490 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 269484000491 HlyD family secretion protein; Region: HlyD_3; pfam13437 269484000492 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 269484000493 COQ9; Region: COQ9; pfam08511 269484000494 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 269484000495 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 269484000496 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 269484000497 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 269484000498 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 269484000499 active site 269484000500 metal binding site [ion binding]; metal-binding site 269484000501 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 269484000502 S17 interaction site [polypeptide binding]; other site 269484000503 S8 interaction site; other site 269484000504 16S rRNA interaction site [nucleotide binding]; other site 269484000505 streptomycin interaction site [chemical binding]; other site 269484000506 23S rRNA interaction site [nucleotide binding]; other site 269484000507 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 269484000508 30S ribosomal protein S7; Validated; Region: PRK05302 269484000509 elongation factor G; Reviewed; Region: PRK00007 269484000510 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 269484000511 G1 box; other site 269484000512 putative GEF interaction site [polypeptide binding]; other site 269484000513 GTP/Mg2+ binding site [chemical binding]; other site 269484000514 Switch I region; other site 269484000515 G2 box; other site 269484000516 G3 box; other site 269484000517 Switch II region; other site 269484000518 G4 box; other site 269484000519 G5 box; other site 269484000520 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 269484000521 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 269484000522 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 269484000523 elongation factor Tu; Reviewed; Region: PRK00049 269484000524 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 269484000525 G1 box; other site 269484000526 GEF interaction site [polypeptide binding]; other site 269484000527 GTP/Mg2+ binding site [chemical binding]; other site 269484000528 Switch I region; other site 269484000529 G2 box; other site 269484000530 G3 box; other site 269484000531 Switch II region; other site 269484000532 G4 box; other site 269484000533 G5 box; other site 269484000534 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 269484000535 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 269484000536 Antibiotic Binding Site [chemical binding]; other site 269484000537 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 269484000538 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 269484000539 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 269484000540 putative homodimer interface [polypeptide binding]; other site 269484000541 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 269484000542 heterodimer interface [polypeptide binding]; other site 269484000543 homodimer interface [polypeptide binding]; other site 269484000544 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 269484000545 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 269484000546 23S rRNA interface [nucleotide binding]; other site 269484000547 L7/L12 interface [polypeptide binding]; other site 269484000548 putative thiostrepton binding site; other site 269484000549 L25 interface [polypeptide binding]; other site 269484000550 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 269484000551 mRNA/rRNA interface [nucleotide binding]; other site 269484000552 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 269484000553 23S rRNA interface [nucleotide binding]; other site 269484000554 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 269484000555 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 269484000556 peripheral dimer interface [polypeptide binding]; other site 269484000557 core dimer interface [polypeptide binding]; other site 269484000558 L10 interface [polypeptide binding]; other site 269484000559 L11 interface [polypeptide binding]; other site 269484000560 putative EF-Tu interaction site [polypeptide binding]; other site 269484000561 putative EF-G interaction site [polypeptide binding]; other site 269484000562 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 269484000563 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 269484000564 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 269484000565 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 269484000566 RPB12 interaction site [polypeptide binding]; other site 269484000567 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 269484000568 RPB3 interaction site [polypeptide binding]; other site 269484000569 RPB1 interaction site [polypeptide binding]; other site 269484000570 RPB11 interaction site [polypeptide binding]; other site 269484000571 RPB10 interaction site [polypeptide binding]; other site 269484000572 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 269484000573 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 269484000574 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 269484000575 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 269484000576 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 269484000577 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 269484000578 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 269484000579 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 269484000580 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 269484000581 DNA binding site [nucleotide binding] 269484000582 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 269484000583 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 269484000584 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 269484000585 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269484000586 catalytic residue [active] 269484000587 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 269484000588 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 269484000589 RNA/DNA hybrid binding site [nucleotide binding]; other site 269484000590 active site 269484000591 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 269484000592 Uncharacterized conserved protein [Function unknown]; Region: COG3334 269484000593 pantothenate kinase; Reviewed; Region: PRK13318 269484000594 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 269484000595 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 269484000596 quinone interaction residues [chemical binding]; other site 269484000597 active site 269484000598 catalytic residues [active] 269484000599 FMN binding site [chemical binding]; other site 269484000600 substrate binding site [chemical binding]; other site 269484000601 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 269484000602 active site 269484000603 catalytic residues [active] 269484000604 metal binding site [ion binding]; metal-binding site 269484000605 argininosuccinate lyase; Provisional; Region: PRK00855 269484000606 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 269484000607 active sites [active] 269484000608 tetramer interface [polypeptide binding]; other site 269484000609 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 269484000610 putative hydrolase; Provisional; Region: PRK11460 269484000611 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 269484000612 active site 269484000613 nucleophile elbow; other site 269484000614 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 269484000615 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 269484000616 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 269484000617 BolA-like protein; Region: BolA; pfam01722 269484000618 Endoribonuclease XendoU; Region: XendoU; pfam09412 269484000619 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 269484000620 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 269484000621 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 269484000622 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 269484000623 putative active site [active] 269484000624 putative PHP Thumb interface [polypeptide binding]; other site 269484000625 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 269484000626 generic binding surface II; other site 269484000627 generic binding surface I; other site 269484000628 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 269484000629 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 269484000630 putative active site [active] 269484000631 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 269484000632 Iron-sulfur protein interface; other site 269484000633 proximal quinone binding site [chemical binding]; other site 269484000634 SdhD (CybS) interface [polypeptide binding]; other site 269484000635 proximal heme binding site [chemical binding]; other site 269484000636 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 269484000637 Iron-sulfur protein interface; other site 269484000638 proximal heme binding site [chemical binding]; other site 269484000639 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 269484000640 dimer interface [polypeptide binding]; other site 269484000641 substrate binding site [chemical binding]; other site 269484000642 ATP binding site [chemical binding]; other site 269484000643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 269484000644 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 269484000645 Walker A motif; other site 269484000646 ATP binding site [chemical binding]; other site 269484000647 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 269484000648 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 269484000649 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 269484000650 RNA binding surface [nucleotide binding]; other site 269484000651 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 269484000652 Domain of unknown function DUF20; Region: UPF0118; pfam01594 269484000653 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 269484000654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 269484000655 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 269484000656 Coenzyme A binding pocket [chemical binding]; other site 269484000657 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 269484000658 tetramer interfaces [polypeptide binding]; other site 269484000659 binuclear metal-binding site [ion binding]; other site 269484000660 trigger factor; Region: tig; TIGR00115 269484000661 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 269484000662 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 269484000663 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 269484000664 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 269484000665 oligomer interface [polypeptide binding]; other site 269484000666 active site residues [active] 269484000667 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 269484000668 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 269484000669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269484000670 Walker A motif; other site 269484000671 ATP binding site [chemical binding]; other site 269484000672 Walker B motif; other site 269484000673 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 269484000674 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 269484000675 Found in ATP-dependent protease La (LON); Region: LON; smart00464 269484000676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269484000677 Walker A motif; other site 269484000678 ATP binding site [chemical binding]; other site 269484000679 Walker B motif; other site 269484000680 arginine finger; other site 269484000681 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 269484000682 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 269484000683 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 269484000684 putative active site [active] 269484000685 substrate binding site [chemical binding]; other site 269484000686 putative cosubstrate binding site; other site 269484000687 catalytic site [active] 269484000688 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 269484000689 substrate binding site [chemical binding]; other site 269484000690 rhodanese superfamily protein; Provisional; Region: PRK05320 269484000691 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 269484000692 active site residue [active] 269484000693 PEP synthetase regulatory protein; Provisional; Region: PRK05339 269484000694 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 269484000695 thiamine phosphate binding site [chemical binding]; other site 269484000696 active site 269484000697 pyrophosphate binding site [ion binding]; other site 269484000698 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 269484000699 Domain of unknown function DUF21; Region: DUF21; pfam01595 269484000700 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 269484000701 Transporter associated domain; Region: CorC_HlyC; smart01091 269484000702 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 269484000703 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 269484000704 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 269484000705 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 269484000706 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 269484000707 inhibitor-cofactor binding pocket; inhibition site 269484000708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269484000709 catalytic residue [active] 269484000710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269484000711 dimer interface [polypeptide binding]; other site 269484000712 phosphorylation site [posttranslational modification] 269484000713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269484000714 ATP binding site [chemical binding]; other site 269484000715 Mg2+ binding site [ion binding]; other site 269484000716 G-X-G motif; other site 269484000717 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 269484000718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269484000719 ATP binding site [chemical binding]; other site 269484000720 Mg2+ binding site [ion binding]; other site 269484000721 G-X-G motif; other site 269484000722 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 269484000723 ATP binding site [chemical binding]; other site 269484000724 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 269484000725 DNA protecting protein DprA; Region: dprA; TIGR00732 269484000726 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 269484000727 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 269484000728 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 269484000729 dimer interface [polypeptide binding]; other site 269484000730 active site 269484000731 acyl carrier protein; Provisional; Region: acpP; PRK00982 269484000732 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269484000733 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 269484000734 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269484000735 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269484000736 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 269484000737 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269484000738 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 269484000739 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 269484000740 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 269484000741 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 269484000742 diiron binding motif [ion binding]; other site 269484000743 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 269484000744 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 269484000745 Ligand Binding Site [chemical binding]; other site 269484000746 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 269484000747 Walker A motif; other site 269484000748 ATP binding site [chemical binding]; other site 269484000749 Walker B motif; other site 269484000750 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 269484000751 Part of AAA domain; Region: AAA_19; pfam13245 269484000752 Family description; Region: UvrD_C_2; pfam13538 269484000753 DNA gyrase subunit A; Validated; Region: PRK05560 269484000754 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 269484000755 CAP-like domain; other site 269484000756 active site 269484000757 primary dimer interface [polypeptide binding]; other site 269484000758 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 269484000759 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 269484000760 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 269484000761 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 269484000762 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 269484000763 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 269484000764 minor groove reading motif; other site 269484000765 helix-hairpin-helix signature motif; other site 269484000766 substrate binding pocket [chemical binding]; other site 269484000767 active site 269484000768 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 269484000769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 269484000770 heat shock protein 90; Provisional; Region: PRK05218 269484000771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269484000772 ATP binding site [chemical binding]; other site 269484000773 Mg2+ binding site [ion binding]; other site 269484000774 G-X-G motif; other site 269484000775 adenylosuccinate lyase; Provisional; Region: PRK07492 269484000776 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 269484000777 tetramer interface [polypeptide binding]; other site 269484000778 active site 269484000779 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 269484000780 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 269484000781 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 269484000782 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 269484000783 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 269484000784 C-terminal domain interface [polypeptide binding]; other site 269484000785 GSH binding site (G-site) [chemical binding]; other site 269484000786 dimer interface [polypeptide binding]; other site 269484000787 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 269484000788 N-terminal domain interface [polypeptide binding]; other site 269484000789 dimer interface [polypeptide binding]; other site 269484000790 substrate binding pocket (H-site) [chemical binding]; other site 269484000791 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 269484000792 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 269484000793 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 269484000794 Walker A/P-loop; other site 269484000795 ATP binding site [chemical binding]; other site 269484000796 Q-loop/lid; other site 269484000797 ABC transporter signature motif; other site 269484000798 Walker B; other site 269484000799 D-loop; other site 269484000800 H-loop/switch region; other site 269484000801 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 269484000802 recombination protein RecR; Reviewed; Region: recR; PRK00076 269484000803 RecR protein; Region: RecR; pfam02132 269484000804 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 269484000805 putative active site [active] 269484000806 putative metal-binding site [ion binding]; other site 269484000807 tetramer interface [polypeptide binding]; other site 269484000808 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 269484000809 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 269484000810 metal binding site [ion binding]; metal-binding site 269484000811 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 269484000812 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269484000813 Walker A/P-loop; other site 269484000814 ATP binding site [chemical binding]; other site 269484000815 Q-loop/lid; other site 269484000816 ABC transporter signature motif; other site 269484000817 Walker B; other site 269484000818 D-loop; other site 269484000819 H-loop/switch region; other site 269484000820 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 269484000821 ABC1 family; Region: ABC1; cl17513 269484000822 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269484000823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269484000824 putative substrate translocation pore; other site 269484000825 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 269484000826 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 269484000827 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269484000828 FeS/SAM binding site; other site 269484000829 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 269484000830 Putative phage tail protein; Region: Phage-tail_3; pfam13550 269484000831 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 269484000832 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 269484000833 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 269484000834 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 269484000835 TPP-binding site [chemical binding]; other site 269484000836 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 269484000837 dimer interface [polypeptide binding]; other site 269484000838 PYR/PP interface [polypeptide binding]; other site 269484000839 TPP binding site [chemical binding]; other site 269484000840 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 269484000841 Phage capsid family; Region: Phage_capsid; pfam05065 269484000842 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 269484000843 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 269484000844 dimer interface [polypeptide binding]; other site 269484000845 active site 269484000846 catalytic residue [active] 269484000847 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 269484000848 nucleotide binding site/active site [active] 269484000849 HIT family signature motif; other site 269484000850 catalytic residue [active] 269484000851 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 269484000852 MutS domain I; Region: MutS_I; pfam01624 269484000853 MutS domain II; Region: MutS_II; pfam05188 269484000854 MutS domain III; Region: MutS_III; pfam05192 269484000855 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 269484000856 Walker A/P-loop; other site 269484000857 ATP binding site [chemical binding]; other site 269484000858 Q-loop/lid; other site 269484000859 ABC transporter signature motif; other site 269484000860 Walker B; other site 269484000861 D-loop; other site 269484000862 H-loop/switch region; other site 269484000863 NAD synthetase; Provisional; Region: PRK13981 269484000864 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 269484000865 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 269484000866 homodimer interface [polypeptide binding]; other site 269484000867 NAD binding pocket [chemical binding]; other site 269484000868 ATP binding pocket [chemical binding]; other site 269484000869 Mg binding site [ion binding]; other site 269484000870 active-site loop [active] 269484000871 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 269484000872 dimer interface [polypeptide binding]; other site 269484000873 allosteric magnesium binding site [ion binding]; other site 269484000874 active site 269484000875 aspartate-rich active site metal binding site; other site 269484000876 Schiff base residues; other site 269484000877 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 269484000878 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 269484000879 metabolite-proton symporter; Region: 2A0106; TIGR00883 269484000880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269484000881 putative substrate translocation pore; other site 269484000882 metabolite-proton symporter; Region: 2A0106; TIGR00883 269484000883 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 269484000884 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 269484000885 dimer interface [polypeptide binding]; other site 269484000886 ssDNA binding site [nucleotide binding]; other site 269484000887 tetramer (dimer of dimers) interface [polypeptide binding]; other site 269484000888 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 269484000889 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 269484000890 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 269484000891 GatB domain; Region: GatB_Yqey; smart00845 269484000892 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 269484000893 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 269484000894 NAD binding site [chemical binding]; other site 269484000895 homotetramer interface [polypeptide binding]; other site 269484000896 homodimer interface [polypeptide binding]; other site 269484000897 substrate binding site [chemical binding]; other site 269484000898 active site 269484000899 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 269484000900 DnaA N-terminal domain; Region: DnaA_N; pfam11638 269484000901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269484000902 Walker A motif; other site 269484000903 ATP binding site [chemical binding]; other site 269484000904 Walker B motif; other site 269484000905 arginine finger; other site 269484000906 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 269484000907 DnaA box-binding interface [nucleotide binding]; other site 269484000908 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 269484000909 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 269484000910 active site 269484000911 (T/H)XGH motif; other site 269484000912 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 269484000913 active site 269484000914 hydrophilic channel; other site 269484000915 dimerization interface [polypeptide binding]; other site 269484000916 catalytic residues [active] 269484000917 active site lid [active] 269484000918 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 269484000919 IHF dimer interface [polypeptide binding]; other site 269484000920 IHF - DNA interface [nucleotide binding]; other site 269484000921 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 269484000922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 269484000923 Walker A motif; other site 269484000924 ATP binding site [chemical binding]; other site 269484000925 Walker B motif; other site 269484000926 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 269484000927 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 269484000928 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 269484000929 CoA-binding site [chemical binding]; other site 269484000930 ATP-binding [chemical binding]; other site 269484000931 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 269484000932 ThiC-associated domain; Region: ThiC-associated; pfam13667 269484000933 ThiC family; Region: ThiC; pfam01964 269484000934 Smr domain; Region: Smr; pfam01713 269484000935 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 269484000936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 269484000937 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 269484000938 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 269484000939 HIGH motif; other site 269484000940 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 269484000941 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 269484000942 active site 269484000943 KMSKS motif; other site 269484000944 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 269484000945 tRNA binding surface [nucleotide binding]; other site 269484000946 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 269484000947 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 269484000948 active site 269484000949 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 269484000950 active site 269484000951 dimer interface [polypeptide binding]; other site 269484000952 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 269484000953 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 269484000954 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 269484000955 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 269484000956 NADH dehydrogenase subunit B; Validated; Region: PRK06411 269484000957 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 269484000958 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 269484000959 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 269484000960 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 269484000961 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 269484000962 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 269484000963 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 269484000964 homopentamer interface [polypeptide binding]; other site 269484000965 active site 269484000966 membrane protein insertase; Provisional; Region: PRK01318 269484000967 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 269484000968 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 269484000969 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 269484000970 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 269484000971 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 269484000972 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 269484000973 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 269484000974 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 269484000975 FAD binding pocket [chemical binding]; other site 269484000976 FAD binding motif [chemical binding]; other site 269484000977 phosphate binding motif [ion binding]; other site 269484000978 beta-alpha-beta structure motif; other site 269484000979 NAD binding pocket [chemical binding]; other site 269484000980 Iron coordination center [ion binding]; other site 269484000981 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 269484000982 elongation factor P; Validated; Region: PRK00529 269484000983 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 269484000984 RNA binding site [nucleotide binding]; other site 269484000985 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 269484000986 RNA binding site [nucleotide binding]; other site 269484000987 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 269484000988 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 269484000989 active site 269484000990 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 269484000991 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 269484000992 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 269484000993 active site 269484000994 response regulator PleD; Reviewed; Region: pleD; PRK09581 269484000995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269484000996 active site 269484000997 phosphorylation site [posttranslational modification] 269484000998 intermolecular recognition site; other site 269484000999 dimerization interface [polypeptide binding]; other site 269484001000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269484001001 active site 269484001002 phosphorylation site [posttranslational modification] 269484001003 intermolecular recognition site; other site 269484001004 dimerization interface [polypeptide binding]; other site 269484001005 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 269484001006 metal binding site [ion binding]; metal-binding site 269484001007 active site 269484001008 I-site; other site 269484001009 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 269484001010 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 269484001011 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 269484001012 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 269484001013 active site 269484001014 HIGH motif; other site 269484001015 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 269484001016 KMSKS motif; other site 269484001017 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 269484001018 tRNA binding surface [nucleotide binding]; other site 269484001019 anticodon binding site; other site 269484001020 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 269484001021 dimer interface [polypeptide binding]; other site 269484001022 putative radical transfer pathway; other site 269484001023 diiron center [ion binding]; other site 269484001024 tyrosyl radical; other site 269484001025 Domain of unknown function (DUF2610); Region: DUF2610; pfam11020 269484001026 Uncharacterized conserved protein [Function unknown]; Region: COG1565 269484001027 DNA primase, catalytic core; Region: dnaG; TIGR01391 269484001028 CHC2 zinc finger; Region: zf-CHC2; pfam01807 269484001029 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 269484001030 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 269484001031 active site 269484001032 metal binding site [ion binding]; metal-binding site 269484001033 interdomain interaction site; other site 269484001034 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 269484001035 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 269484001036 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269484001037 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 269484001038 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 269484001039 DNA binding residues [nucleotide binding] 269484001040 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 269484001041 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 269484001042 FMN binding site [chemical binding]; other site 269484001043 active site 269484001044 catalytic residues [active] 269484001045 substrate binding site [chemical binding]; other site 269484001046 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14610 269484001047 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 269484001048 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 269484001049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269484001050 dimer interface [polypeptide binding]; other site 269484001051 phosphorylation site [posttranslational modification] 269484001052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269484001053 ATP binding site [chemical binding]; other site 269484001054 Mg2+ binding site [ion binding]; other site 269484001055 G-X-G motif; other site 269484001056 Response regulator receiver domain; Region: Response_reg; pfam00072 269484001057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269484001058 active site 269484001059 phosphorylation site [posttranslational modification] 269484001060 intermolecular recognition site; other site 269484001061 dimerization interface [polypeptide binding]; other site 269484001062 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 269484001063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 269484001064 putative carbohydrate kinase; Provisional; Region: PRK10565 269484001065 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 269484001066 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 269484001067 putative substrate binding site [chemical binding]; other site 269484001068 putative ATP binding site [chemical binding]; other site 269484001069 DNA topoisomerase I; Validated; Region: PRK06599 269484001070 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 269484001071 active site 269484001072 interdomain interaction site; other site 269484001073 putative metal-binding site [ion binding]; other site 269484001074 nucleotide binding site [chemical binding]; other site 269484001075 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 269484001076 domain I; other site 269484001077 DNA binding groove [nucleotide binding] 269484001078 phosphate binding site [ion binding]; other site 269484001079 domain II; other site 269484001080 domain III; other site 269484001081 nucleotide binding site [chemical binding]; other site 269484001082 catalytic site [active] 269484001083 domain IV; other site 269484001084 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 269484001085 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 269484001086 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 269484001087 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 269484001088 Stringent starvation protein B; Region: SspB; pfam04386 269484001089 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14659 269484001090 prolyl-tRNA synthetase; Provisional; Region: PRK12325 269484001091 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 269484001092 dimer interface [polypeptide binding]; other site 269484001093 motif 1; other site 269484001094 active site 269484001095 motif 2; other site 269484001096 motif 3; other site 269484001097 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 269484001098 anticodon binding site; other site 269484001099 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 269484001100 conserved cys residue [active] 269484001101 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 269484001102 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 269484001103 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 269484001104 active site 269484001105 (T/H)XGH motif; other site 269484001106 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 269484001107 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 269484001108 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269484001109 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 269484001110 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 269484001111 dimer interface [polypeptide binding]; other site 269484001112 decamer (pentamer of dimers) interface [polypeptide binding]; other site 269484001113 catalytic triad [active] 269484001114 peroxidatic and resolving cysteines [active] 269484001115 aspartate aminotransferase; Provisional; Region: PRK05764 269484001116 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 269484001117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269484001118 homodimer interface [polypeptide binding]; other site 269484001119 catalytic residue [active] 269484001120 SurA N-terminal domain; Region: SurA_N_3; cl07813 269484001121 periplasmic folding chaperone; Provisional; Region: PRK10788 269484001122 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 269484001123 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 269484001124 Glycoprotease family; Region: Peptidase_M22; pfam00814 269484001125 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 269484001126 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 269484001127 RNA binding site [nucleotide binding]; other site 269484001128 active site 269484001129 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 269484001130 16S/18S rRNA binding site [nucleotide binding]; other site 269484001131 S13e-L30e interaction site [polypeptide binding]; other site 269484001132 25S rRNA binding site [nucleotide binding]; other site 269484001133 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 269484001134 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 269484001135 RNase E interface [polypeptide binding]; other site 269484001136 trimer interface [polypeptide binding]; other site 269484001137 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 269484001138 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 269484001139 RNase E interface [polypeptide binding]; other site 269484001140 trimer interface [polypeptide binding]; other site 269484001141 active site 269484001142 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 269484001143 putative nucleic acid binding region [nucleotide binding]; other site 269484001144 G-X-X-G motif; other site 269484001145 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 269484001146 RNA binding site [nucleotide binding]; other site 269484001147 domain interface; other site 269484001148 Methyltransferase domain; Region: Methyltransf_11; pfam08241 269484001149 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 269484001150 GTP-binding protein LepA; Provisional; Region: PRK05433 269484001151 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 269484001152 G1 box; other site 269484001153 putative GEF interaction site [polypeptide binding]; other site 269484001154 GTP/Mg2+ binding site [chemical binding]; other site 269484001155 Switch I region; other site 269484001156 G2 box; other site 269484001157 G3 box; other site 269484001158 Switch II region; other site 269484001159 G4 box; other site 269484001160 G5 box; other site 269484001161 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 269484001162 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 269484001163 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 269484001164 Protein of unknown function (DUF721); Region: DUF721; pfam05258 269484001165 peptide chain release factor 2; Validated; Region: prfB; PRK00578 269484001166 This domain is found in peptide chain release factors; Region: PCRF; smart00937 269484001167 RF-1 domain; Region: RF-1; pfam00472 269484001168 hypothetical protein; Validated; Region: PRK00110 269484001169 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 269484001170 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 269484001171 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 269484001172 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 269484001173 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 269484001174 domain interfaces; other site 269484001175 active site 269484001176 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 269484001177 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 269484001178 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 269484001179 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 269484001180 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 269484001181 G1 box; other site 269484001182 putative GEF interaction site [polypeptide binding]; other site 269484001183 GTP/Mg2+ binding site [chemical binding]; other site 269484001184 Switch I region; other site 269484001185 G2 box; other site 269484001186 G3 box; other site 269484001187 Switch II region; other site 269484001188 G4 box; other site 269484001189 G5 box; other site 269484001190 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 269484001191 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 269484001192 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 269484001193 4Fe-4S binding domain; Region: Fer4; cl02805 269484001194 4Fe-4S binding domain; Region: Fer4; pfam00037 269484001195 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 269484001196 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 269484001197 Catalytic site [active] 269484001198 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 269484001199 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 269484001200 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 269484001201 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 269484001202 Zn2+ binding site [ion binding]; other site 269484001203 Mg2+ binding site [ion binding]; other site 269484001204 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 269484001205 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269484001206 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269484001207 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269484001208 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269484001209 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269484001210 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269484001211 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269484001212 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269484001213 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269484001214 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269484001215 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269484001216 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269484001217 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269484001218 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269484001219 argininosuccinate synthase; Provisional; Region: PRK13820 269484001220 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 269484001221 ANP binding site [chemical binding]; other site 269484001222 Substrate Binding Site II [chemical binding]; other site 269484001223 Substrate Binding Site I [chemical binding]; other site 269484001224 Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell division and chromosome partitioning]; Region: NIP100; COG5244 269484001225 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 269484001226 heterotetramer interface [polypeptide binding]; other site 269484001227 active site pocket [active] 269484001228 cleavage site 269484001229 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 269484001230 putative catalytic site [active] 269484001231 putative phosphate binding site [ion binding]; other site 269484001232 active site 269484001233 metal binding site A [ion binding]; metal-binding site 269484001234 DNA binding site [nucleotide binding] 269484001235 putative AP binding site [nucleotide binding]; other site 269484001236 putative metal binding site B [ion binding]; other site 269484001237 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 269484001238 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 269484001239 NAD(P) binding site [chemical binding]; other site 269484001240 homotetramer interface [polypeptide binding]; other site 269484001241 homodimer interface [polypeptide binding]; other site 269484001242 active site 269484001243 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 269484001244 Proline dehydrogenase; Region: Pro_dh; pfam01619 269484001245 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 269484001246 Glutamate binding site [chemical binding]; other site 269484001247 NAD binding site [chemical binding]; other site 269484001248 catalytic residues [active] 269484001249 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 269484001250 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 269484001251 inhibitor-cofactor binding pocket; inhibition site 269484001252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 269484001253 catalytic residue [active] 269484001254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 269484001255 Terminase-like family; Region: Terminase_6; pfam03237 269484001256 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 269484001257 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 269484001258 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 269484001259 oligomerization interface [polypeptide binding]; other site 269484001260 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 269484001261 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 269484001262 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 269484001263 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 269484001264 DNA binding residues [nucleotide binding] 269484001265 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 269484001266 30S subunit binding site; other site 269484001267 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269484001268 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269484001269 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 269484001270 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269484001271 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269484001272 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269484001273 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 269484001274 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 269484001275 core domain interface [polypeptide binding]; other site 269484001276 delta subunit interface [polypeptide binding]; other site 269484001277 epsilon subunit interface [polypeptide binding]; other site 269484001278 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 269484001279 GTP cyclohydrolase I; Provisional; Region: PLN03044 269484001280 active site 269484001281 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 269484001282 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 269484001283 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 269484001284 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269484001285 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 269484001286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269484001287 S-adenosylmethionine binding site [chemical binding]; other site 269484001288 triosephosphate isomerase; Provisional; Region: PRK14565 269484001289 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 269484001290 substrate binding site [chemical binding]; other site 269484001291 dimer interface [polypeptide binding]; other site 269484001292 catalytic triad [active] 269484001293 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 269484001294 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 269484001295 UGMP family protein; Validated; Region: PRK09604 269484001296 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 269484001297 RDD family; Region: RDD; pfam06271 269484001298 Dihydroneopterin aldolase; Region: FolB; smart00905 269484001299 active site 269484001300 malate dehydrogenase; Reviewed; Region: PRK06223 269484001301 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 269484001302 NAD(P) binding site [chemical binding]; other site 269484001303 dimer interface [polypeptide binding]; other site 269484001304 tetramer (dimer of dimers) interface [polypeptide binding]; other site 269484001305 substrate binding site [chemical binding]; other site 269484001306 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 269484001307 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 269484001308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269484001309 S-adenosylmethionine binding site [chemical binding]; other site 269484001310 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 269484001311 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 269484001312 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 269484001313 catalytic loop [active] 269484001314 iron binding site [ion binding]; other site 269484001315 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 269484001316 Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991 269484001317 nucleotide binding site [chemical binding]; other site 269484001318 putative NEF/HSP70 interaction site [polypeptide binding]; other site 269484001319 SBD interface [polypeptide binding]; other site 269484001320 co-chaperone HscB; Provisional; Region: hscB; PRK05014 269484001321 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 269484001322 HSP70 interaction site [polypeptide binding]; other site 269484001323 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 269484001324 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 269484001325 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 269484001326 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 269484001327 trimerization site [polypeptide binding]; other site 269484001328 active site 269484001329 cysteine desulfurase; Provisional; Region: PRK14012 269484001330 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 269484001331 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269484001332 catalytic residue [active] 269484001333 Transcriptional regulator; Region: Rrf2; cl17282 269484001334 Rrf2 family protein; Region: rrf2_super; TIGR00738 269484001335 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 269484001336 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 269484001337 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 269484001338 catalytic residue [active] 269484001339 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 269484001340 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 269484001341 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 269484001342 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 269484001343 active site 269484001344 nucleotide binding site [chemical binding]; other site 269484001345 HIGH motif; other site 269484001346 KMSKS motif; other site 269484001347 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 269484001348 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 269484001349 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 269484001350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269484001351 ATP binding site [chemical binding]; other site 269484001352 Mg2+ binding site [ion binding]; other site 269484001353 G-X-G motif; other site 269484001354 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 269484001355 anchoring element; other site 269484001356 dimer interface [polypeptide binding]; other site 269484001357 ATP binding site [chemical binding]; other site 269484001358 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 269484001359 active site 269484001360 putative metal-binding site [ion binding]; other site 269484001361 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 269484001362 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 269484001363 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 269484001364 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 269484001365 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 269484001366 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 269484001367 dimerization interface 3.5A [polypeptide binding]; other site 269484001368 active site 269484001369 NADH dehydrogenase subunit G; Validated; Region: PRK09130 269484001370 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 269484001371 catalytic loop [active] 269484001372 iron binding site [ion binding]; other site 269484001373 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 269484001374 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 269484001375 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 269484001376 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 269484001377 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 269484001378 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 269484001379 NADH dehydrogenase subunit D; Validated; Region: PRK06075 269484001380 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 269484001381 NADH dehydrogenase subunit E; Validated; Region: PRK07539 269484001382 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 269484001383 putative dimer interface [polypeptide binding]; other site 269484001384 [2Fe-2S] cluster binding site [ion binding]; other site 269484001385 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 269484001386 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 269484001387 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 269484001388 Protein of unknown function (DUF3023); Region: DUF3023; pfam11224 269484001389 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 269484001390 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 269484001391 active site 269484001392 HIGH motif; other site 269484001393 nucleotide binding site [chemical binding]; other site 269484001394 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 269484001395 active site 269484001396 KMSKS motif; other site 269484001397 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 269484001398 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 269484001399 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 269484001400 RF-1 domain; Region: RF-1; pfam00472 269484001401 peptide chain release factor 1; Validated; Region: prfA; PRK00591 269484001402 This domain is found in peptide chain release factors; Region: PCRF; smart00937 269484001403 RF-1 domain; Region: RF-1; pfam00472 269484001404 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 269484001405 G1 box; other site 269484001406 GTP/Mg2+ binding site [chemical binding]; other site 269484001407 Switch I region; other site 269484001408 G2 box; other site 269484001409 G3 box; other site 269484001410 Switch II region; other site 269484001411 G4 box; other site 269484001412 G5 box; other site 269484001413 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 269484001414 feedback inhibition sensing region; other site 269484001415 homohexameric interface [polypeptide binding]; other site 269484001416 nucleotide binding site [chemical binding]; other site 269484001417 N-acetyl-L-glutamate binding site [chemical binding]; other site 269484001418 Gram-negative porin; Region: Porin_4; pfam13609 269484001419 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 269484001420 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 269484001421 RmuC family; Region: RmuC; pfam02646 269484001422 VirB8 protein; Region: VirB8; cl01500 269484001423 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 269484001424 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 269484001425 seryl-tRNA synthetase; Provisional; Region: PRK05431 269484001426 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 269484001427 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 269484001428 dimer interface [polypeptide binding]; other site 269484001429 active site 269484001430 motif 1; other site 269484001431 motif 2; other site 269484001432 motif 3; other site 269484001433 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 269484001434 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 269484001435 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 269484001436 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 269484001437 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 269484001438 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 269484001439 MgtE intracellular N domain; Region: MgtE_N; smart00924 269484001440 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 269484001441 Divalent cation transporter; Region: MgtE; cl00786 269484001442 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 269484001443 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 269484001444 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 269484001445 alpha subunit interaction interface [polypeptide binding]; other site 269484001446 Walker A motif; other site 269484001447 ATP binding site [chemical binding]; other site 269484001448 Walker B motif; other site 269484001449 inhibitor binding site; inhibition site 269484001450 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 269484001451 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13444 269484001452 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823 269484001453 gamma subunit interface [polypeptide binding]; other site 269484001454 epsilon subunit interface [polypeptide binding]; other site 269484001455 LBP interface [polypeptide binding]; other site 269484001456 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 269484001457 active site 269484001458 intersubunit interactions; other site 269484001459 catalytic residue [active] 269484001460 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 269484001461 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 269484001462 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 269484001463 Clp amino terminal domain; Region: Clp_N; pfam02861 269484001464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269484001465 Walker A motif; other site 269484001466 ATP binding site [chemical binding]; other site 269484001467 Walker B motif; other site 269484001468 arginine finger; other site 269484001469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 269484001470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269484001471 Walker A motif; other site 269484001472 ATP binding site [chemical binding]; other site 269484001473 Walker B motif; other site 269484001474 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 269484001475 Integral membrane protein TerC family; Region: TerC; cl10468 269484001476 Ribosome-binding factor A; Region: RBFA; pfam02033 269484001477 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 269484001478 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 269484001479 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 269484001480 G1 box; other site 269484001481 putative GEF interaction site [polypeptide binding]; other site 269484001482 GTP/Mg2+ binding site [chemical binding]; other site 269484001483 Switch I region; other site 269484001484 G2 box; other site 269484001485 G3 box; other site 269484001486 Switch II region; other site 269484001487 G4 box; other site 269484001488 G5 box; other site 269484001489 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 269484001490 Translation-initiation factor 2; Region: IF-2; pfam11987 269484001491 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 269484001492 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 269484001493 NusA N-terminal domain; Region: NusA_N; pfam08529 269484001494 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 269484001495 RNA binding site [nucleotide binding]; other site 269484001496 homodimer interface [polypeptide binding]; other site 269484001497 NusA-like KH domain; Region: KH_5; pfam13184 269484001498 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 269484001499 G-X-X-G motif; other site 269484001500 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 269484001501 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 269484001502 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 269484001503 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 269484001504 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 269484001505 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 269484001506 DNA topoisomerase 2-like protein; Provisional; Region: PTZ00108 269484001507 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 269484001508 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 269484001509 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 269484001510 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 269484001511 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 269484001512 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269484001513 NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008 269484001514 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269484001515 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 269484001516 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 269484001517 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269484001518 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 269484001519 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 269484001520 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00057 269484001521 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 269484001522 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 269484001523 SLBB domain; Region: SLBB; pfam10531 269484001524 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 269484001525 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 269484001526 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 269484001527 enolase; Provisional; Region: eno; PRK00077 269484001528 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 269484001529 dimer interface [polypeptide binding]; other site 269484001530 metal binding site [ion binding]; metal-binding site 269484001531 substrate binding pocket [chemical binding]; other site 269484001532 GTPase CgtA; Reviewed; Region: obgE; PRK12299 269484001533 GTP1/OBG; Region: GTP1_OBG; pfam01018 269484001534 Obg GTPase; Region: Obg; cd01898 269484001535 G1 box; other site 269484001536 GTP/Mg2+ binding site [chemical binding]; other site 269484001537 Switch I region; other site 269484001538 G2 box; other site 269484001539 G3 box; other site 269484001540 Switch II region; other site 269484001541 G4 box; other site 269484001542 G5 box; other site 269484001543 MraW methylase family; Region: Methyltransf_5; cl17771 269484001544 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 269484001545 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 269484001546 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 269484001547 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 269484001548 RNA methyltransferase, RsmE family; Region: TIGR00046 269484001549 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 269484001550 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 269484001551 catalytic triad [active] 269484001552 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 269484001553 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 269484001554 HIGH motif; other site 269484001555 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 269484001556 active site 269484001557 KMSKS motif; other site 269484001558 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 269484001559 tRNA binding surface [nucleotide binding]; other site 269484001560 anticodon binding site; other site 269484001561 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 269484001562 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 269484001563 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 269484001564 active site 269484001565 HIGH motif; other site 269484001566 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 269484001567 KMSK motif region; other site 269484001568 tRNA binding surface [nucleotide binding]; other site 269484001569 DALR anticodon binding domain; Region: DALR_1; smart00836 269484001570 anticodon binding site; other site 269484001571 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 269484001572 Recombination protein O N terminal; Region: RecO_N; pfam11967 269484001573 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 269484001574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269484001575 S-adenosylmethionine binding site [chemical binding]; other site 269484001576 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 269484001577 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 269484001578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269484001579 Walker A motif; other site 269484001580 ATP binding site [chemical binding]; other site 269484001581 Walker B motif; other site 269484001582 arginine finger; other site 269484001583 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 269484001584 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 269484001585 thiamine monophosphate kinase; Provisional; Region: PRK05731 269484001586 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 269484001587 ATP binding site [chemical binding]; other site 269484001588 dimerization interface [polypeptide binding]; other site 269484001589 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 269484001590 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 269484001591 active site 269484001592 catalytic site [active] 269484001593 substrate binding site [chemical binding]; other site 269484001594 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 269484001595 arCOG04150 universal archaeal KH domain protein; Region: arCOG04150; TIGR03665 269484001596 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 269484001597 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 269484001598 Qi binding site; other site 269484001599 intrachain domain interface; other site 269484001600 interchain domain interface [polypeptide binding]; other site 269484001601 cytochrome b; Provisional; Region: CYTB; MTH00156 269484001602 heme bH binding site [chemical binding]; other site 269484001603 heme bL binding site [chemical binding]; other site 269484001604 Qo binding site; other site 269484001605 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 269484001606 interchain domain interface [polypeptide binding]; other site 269484001607 intrachain domain interface; other site 269484001608 Qi binding site; other site 269484001609 Qo binding site; other site 269484001610 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 269484001611 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 269484001612 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 269484001613 [2Fe-2S] cluster binding site [ion binding]; other site 269484001614 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 269484001615 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 269484001616 ABC-ATPase subunit interface; other site 269484001617 dimer interface [polypeptide binding]; other site 269484001618 putative PBP binding regions; other site 269484001619 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 269484001620 elongation factor Ts; Provisional; Region: tsf; PRK09377 269484001621 UBA/TS-N domain; Region: UBA; pfam00627 269484001622 Elongation factor TS; Region: EF_TS; pfam00889 269484001623 Elongation factor TS; Region: EF_TS; pfam00889 269484001624 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 269484001625 rRNA interaction site [nucleotide binding]; other site 269484001626 S8 interaction site; other site 269484001627 putative laminin-1 binding site; other site 269484001628 Maf-like protein; Region: Maf; pfam02545 269484001629 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 269484001630 active site 269484001631 dimer interface [polypeptide binding]; other site 269484001632 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 269484001633 rRNA binding site [nucleotide binding]; other site 269484001634 predicted 30S ribosome binding site; other site 269484001635 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 269484001636 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 269484001637 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 269484001638 HlyD family secretion protein; Region: HlyD_3; pfam13437 269484001639 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 269484001640 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 269484001641 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 269484001642 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 269484001643 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 269484001644 PQQ-like domain; Region: PQQ_2; pfam13360 269484001645 Trp docking motif [polypeptide binding]; other site 269484001646 active site 269484001647 PQQ-like domain; Region: PQQ_2; pfam13360 269484001648 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 269484001649 phosphoglyceromutase; Provisional; Region: PRK05434 269484001650 GTP-binding protein Der; Reviewed; Region: PRK00093 269484001651 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 269484001652 G1 box; other site 269484001653 GTP/Mg2+ binding site [chemical binding]; other site 269484001654 Switch I region; other site 269484001655 G2 box; other site 269484001656 Switch II region; other site 269484001657 G3 box; other site 269484001658 G4 box; other site 269484001659 G5 box; other site 269484001660 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 269484001661 G1 box; other site 269484001662 GTP/Mg2+ binding site [chemical binding]; other site 269484001663 Switch I region; other site 269484001664 G2 box; other site 269484001665 G3 box; other site 269484001666 Switch II region; other site 269484001667 G4 box; other site 269484001668 G5 box; other site 269484001669 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 269484001670 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 269484001671 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 269484001672 catalytic site [active] 269484001673 subunit interface [polypeptide binding]; other site 269484001674 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 269484001675 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 269484001676 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 269484001677 trimer interface [polypeptide binding]; other site 269484001678 active site 269484001679 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 269484001680 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 269484001681 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 269484001682 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 269484001683 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 269484001684 type IV secretion system ATPase VirB4; Provisional; Region: PRK13898 269484001685 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 269484001686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269484001687 Walker A/P-loop; other site 269484001688 ATP binding site [chemical binding]; other site 269484001689 type IV secretion system protein VirB3; Provisional; Region: PRK13899 269484001690 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 269484001691 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 269484001692 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 269484001693 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 269484001694 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 269484001695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 269484001696 dimer interface [polypeptide binding]; other site 269484001697 conserved gate region; other site 269484001698 putative PBP binding loops; other site 269484001699 ABC-ATPase subunit interface; other site 269484001700 lipoyl synthase; Provisional; Region: PRK05481 269484001701 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269484001702 FeS/SAM binding site; other site 269484001703 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 269484001704 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269484001705 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 269484001706 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 269484001707 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 269484001708 carboxyltransferase (CT) interaction site; other site 269484001709 biotinylation site [posttranslational modification]; other site 269484001710 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 269484001711 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 269484001712 RNA binding surface [nucleotide binding]; other site 269484001713 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 269484001714 active site 269484001715 diaminopimelate decarboxylase; Region: lysA; TIGR01048 269484001716 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 269484001717 active site 269484001718 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 269484001719 substrate binding site [chemical binding]; other site 269484001720 catalytic residues [active] 269484001721 dimer interface [polypeptide binding]; other site 269484001722 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 269484001723 primosome assembly protein PriA; Validated; Region: PRK05580 269484001724 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269484001725 ATP binding site [chemical binding]; other site 269484001726 putative Mg++ binding site [ion binding]; other site 269484001727 helicase superfamily c-terminal domain; Region: HELICc; smart00490 269484001728 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 269484001729 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 269484001730 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 269484001731 active site 269484001732 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 269484001733 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 269484001734 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 269484001735 active site 269484001736 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 269484001737 catalytic motif [active] 269484001738 Catalytic residue [active] 269484001739 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 269484001740 active site 269484001741 catalytic site [active] 269484001742 substrate binding site [chemical binding]; other site 269484001743 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 269484001744 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 269484001745 GTPase Era; Reviewed; Region: era; PRK00089 269484001746 G1 box; other site 269484001747 GTP/Mg2+ binding site [chemical binding]; other site 269484001748 Switch I region; other site 269484001749 G2 box; other site 269484001750 Switch II region; other site 269484001751 G3 box; other site 269484001752 G4 box; other site 269484001753 G5 box; other site 269484001754 KH domain; Region: KH_2; pfam07650 269484001755 signal recognition particle protein; Provisional; Region: PRK10867 269484001756 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 269484001757 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 269484001758 P loop; other site 269484001759 GTP binding site [chemical binding]; other site 269484001760 Signal peptide binding domain; Region: SRP_SPB; pfam02978 269484001761 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12664 269484001762 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269484001763 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 269484001764 putative coenzyme Q binding site [chemical binding]; other site 269484001765 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 269484001766 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 269484001767 nucleotide binding site [chemical binding]; other site 269484001768 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 269484001769 RNA binding site [nucleotide binding]; other site 269484001770 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 269484001771 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 269484001772 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 269484001773 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12508 269484001774 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12504 269484001775 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 269484001776 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 269484001777 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12670 269484001778 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12603 269484001779 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 269484001780 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 269484001781 TPP-binding site [chemical binding]; other site 269484001782 dimer interface [polypeptide binding]; other site 269484001783 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 269484001784 PYR/PP interface [polypeptide binding]; other site 269484001785 dimer interface [polypeptide binding]; other site 269484001786 TPP binding site [chemical binding]; other site 269484001787 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 269484001788 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 269484001789 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 269484001790 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 269484001791 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 269484001792 ligand binding site [chemical binding]; other site 269484001793 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 269484001794 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 269484001795 GDP-binding site [chemical binding]; other site 269484001796 ACT binding site; other site 269484001797 IMP binding site; other site 269484001798 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 269484001799 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 269484001800 Class I ribonucleotide reductase; Region: RNR_I; cd01679 269484001801 active site 269484001802 dimer interface [polypeptide binding]; other site 269484001803 catalytic residues [active] 269484001804 effector binding site; other site 269484001805 R2 peptide binding site; other site 269484001806 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 269484001807 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 269484001808 substrate binding pocket [chemical binding]; other site 269484001809 chain length determination region; other site 269484001810 substrate-Mg2+ binding site; other site 269484001811 catalytic residues [active] 269484001812 aspartate-rich region 1; other site 269484001813 active site lid residues [active] 269484001814 aspartate-rich region 2; other site 269484001815 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 269484001816 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 269484001817 replicative DNA helicase; Provisional; Region: PRK09165 269484001818 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 269484001819 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 269484001820 Walker A motif; other site 269484001821 ATP binding site [chemical binding]; other site 269484001822 Walker B motif; other site 269484001823 DNA binding loops [nucleotide binding] 269484001824 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 269484001825 nucleoside/Zn binding site; other site 269484001826 dimer interface [polypeptide binding]; other site 269484001827 catalytic motif [active] 269484001828 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 269484001829 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 269484001830 dimer interface [polypeptide binding]; other site 269484001831 active site 269484001832 CoA binding pocket [chemical binding]; other site 269484001833 putative phosphate acyltransferase; Provisional; Region: PRK05331 269484001834 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 269484001835 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 269484001836 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 269484001837 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14244 269484001838 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 269484001839 Walker A/P-loop; other site 269484001840 ATP binding site [chemical binding]; other site 269484001841 Q-loop/lid; other site 269484001842 ABC transporter signature motif; other site 269484001843 Walker B; other site 269484001844 D-loop; other site 269484001845 H-loop/switch region; other site 269484001846 dihydrodipicolinate reductase; Provisional; Region: PRK00048 269484001847 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 269484001848 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 269484001849 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 269484001850 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 269484001851 UbiA prenyltransferase family; Region: UbiA; pfam01040 269484001852 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 269484001853 UbiA prenyltransferase family; Region: UbiA; pfam01040 269484001854 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 269484001855 Ribonuclease P; Region: Ribonuclease_P; pfam00825 269484001856 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 269484001857 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 269484001858 Competence protein; Region: Competence; pfam03772 269484001859 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 269484001860 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 269484001861 putative tRNA-binding site [nucleotide binding]; other site 269484001862 B3/4 domain; Region: B3_4; pfam03483 269484001863 tRNA synthetase B5 domain; Region: B5; smart00874 269484001864 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 269484001865 dimer interface [polypeptide binding]; other site 269484001866 motif 1; other site 269484001867 motif 3; other site 269484001868 motif 2; other site 269484001869 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 269484001870 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 269484001871 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 269484001872 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 269484001873 alphaNTD homodimer interface [polypeptide binding]; other site 269484001874 alphaNTD - beta interaction site [polypeptide binding]; other site 269484001875 alphaNTD - beta' interaction site [polypeptide binding]; other site 269484001876 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 269484001877 30S ribosomal protein S11; Validated; Region: PRK05309 269484001878 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 269484001879 30S ribosomal protein S13; Region: bact_S13; TIGR03631 269484001880 adenylate kinase; Region: adk; TIGR01351 269484001881 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 269484001882 AMP-binding site [chemical binding]; other site 269484001883 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 269484001884 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 269484001885 SecY translocase; Region: SecY; pfam00344 269484001886 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 269484001887 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 269484001888 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 269484001889 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 269484001890 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 269484001891 5S rRNA interface [nucleotide binding]; other site 269484001892 23S rRNA interface [nucleotide binding]; other site 269484001893 L5 interface [polypeptide binding]; other site 269484001894 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 269484001895 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 269484001896 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 269484001897 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 269484001898 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 269484001899 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 269484001900 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 269484001901 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 269484001902 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 269484001903 RNA binding site [nucleotide binding]; other site 269484001904 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 269484001905 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 269484001906 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 269484001907 putative translocon interaction site; other site 269484001908 23S rRNA interface [nucleotide binding]; other site 269484001909 signal recognition particle (SRP54) interaction site; other site 269484001910 L23 interface [polypeptide binding]; other site 269484001911 trigger factor interaction site; other site 269484001912 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 269484001913 23S rRNA interface [nucleotide binding]; other site 269484001914 5S rRNA interface [nucleotide binding]; other site 269484001915 putative antibiotic binding site [chemical binding]; other site 269484001916 L25 interface [polypeptide binding]; other site 269484001917 L27 interface [polypeptide binding]; other site 269484001918 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 269484001919 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 269484001920 G-X-X-G motif; other site 269484001921 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 269484001922 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 269484001923 putative translocon binding site; other site 269484001924 protein-rRNA interface [nucleotide binding]; other site 269484001925 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 269484001926 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 269484001927 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 269484001928 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 269484001929 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 269484001930 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 269484001931 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 269484001932 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 269484001933 elongation factor Tu; Reviewed; Region: PRK00049 269484001934 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 269484001935 G1 box; other site 269484001936 GEF interaction site [polypeptide binding]; other site 269484001937 GTP/Mg2+ binding site [chemical binding]; other site 269484001938 Switch I region; other site 269484001939 G2 box; other site 269484001940 G3 box; other site 269484001941 Switch II region; other site 269484001942 G4 box; other site 269484001943 G5 box; other site 269484001944 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 269484001945 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 269484001946 Antibiotic Binding Site [chemical binding]; other site 269484001947 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 269484001948 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 269484001949 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 269484001950 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 269484001951 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 269484001952 CMP-binding site; other site 269484001953 The sites determining sugar specificity; other site 269484001954 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 269484001955 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 269484001956 RNA binding site [nucleotide binding]; other site 269484001957 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 269484001958 RNA binding site [nucleotide binding]; other site 269484001959 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 269484001960 RNA binding site [nucleotide binding]; other site 269484001961 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 269484001962 RNA binding site [nucleotide binding]; other site 269484001963 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 269484001964 RNA binding site [nucleotide binding]; other site 269484001965 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 269484001966 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 269484001967 tandem repeat interface [polypeptide binding]; other site 269484001968 oligomer interface [polypeptide binding]; other site 269484001969 active site residues [active] 269484001970 Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216 269484001971 IHF - DNA interface [nucleotide binding]; other site 269484001972 IHF dimer interface [polypeptide binding]; other site 269484001973 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 269484001974 Cell division protein ZapA; Region: ZapA; pfam05164 269484001975 ferrochelatase; Reviewed; Region: hemH; PRK00035 269484001976 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 269484001977 C-terminal domain interface [polypeptide binding]; other site 269484001978 active site 269484001979 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 269484001980 active site 269484001981 N-terminal domain interface [polypeptide binding]; other site 269484001982 Predicted ATPase [General function prediction only]; Region: COG1485 269484001983 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 269484001984 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 269484001985 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 269484001986 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 269484001987 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 269484001988 Family description; Region: UvrD_C_2; pfam13538 269484001989 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 269484001990 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 269484001991 NADP binding site [chemical binding]; other site 269484001992 dimer interface [polypeptide binding]; other site 269484001993 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 269484001994 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269484001995 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269484001996 Walker A/P-loop; other site 269484001997 ATP binding site [chemical binding]; other site 269484001998 Q-loop/lid; other site 269484001999 ABC transporter signature motif; other site 269484002000 Walker B; other site 269484002001 D-loop; other site 269484002002 H-loop/switch region; other site 269484002003 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 269484002004 dihydropteroate synthase; Region: DHPS; TIGR01496 269484002005 substrate binding pocket [chemical binding]; other site 269484002006 dimer interface [polypeptide binding]; other site 269484002007 inhibitor binding site; inhibition site 269484002008 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 269484002009 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269484002010 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269484002011 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 269484002012 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 269484002013 ATP-grasp domain; Region: ATP-grasp_4; cl17255 269484002014 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 269484002015 IMP binding site; other site 269484002016 dimer interface [polypeptide binding]; other site 269484002017 interdomain contacts; other site 269484002018 partial ornithine binding site; other site 269484002019 fumarate hydratase; Reviewed; Region: fumC; PRK00485 269484002020 Class II fumarases; Region: Fumarase_classII; cd01362 269484002021 active site 269484002022 tetramer interface [polypeptide binding]; other site 269484002023 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 269484002024 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 269484002025 dihydroorotase; Validated; Region: pyrC; PRK09357 269484002026 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 269484002027 active site 269484002028 lipoate-protein ligase B; Provisional; Region: PRK14341 269484002029 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 269484002030 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 269484002031 active site 269484002032 substrate binding site [chemical binding]; other site 269484002033 cosubstrate binding site; other site 269484002034 catalytic site [active] 269484002035 multifunctional aminopeptidase A; Provisional; Region: PRK00913 269484002036 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 269484002037 interface (dimer of trimers) [polypeptide binding]; other site 269484002038 Substrate-binding/catalytic site; other site 269484002039 Zn-binding sites [ion binding]; other site 269484002040 Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459 269484002041 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 269484002042 Clp amino terminal domain; Region: Clp_N; pfam02861 269484002043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269484002044 Walker A motif; other site 269484002045 ATP binding site [chemical binding]; other site 269484002046 Walker B motif; other site 269484002047 arginine finger; other site 269484002048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269484002049 Walker A motif; other site 269484002050 ATP binding site [chemical binding]; other site 269484002051 Walker B motif; other site 269484002052 arginine finger; other site 269484002053 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 269484002054 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 269484002055 classical (c) SDRs; Region: SDR_c; cd05233 269484002056 NAD(P) binding site [chemical binding]; other site 269484002057 active site 269484002058 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 269484002059 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 269484002060 ring oligomerisation interface [polypeptide binding]; other site 269484002061 ATP/Mg binding site [chemical binding]; other site 269484002062 stacking interactions; other site 269484002063 hinge regions; other site 269484002064 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 269484002065 oligomerisation interface [polypeptide binding]; other site 269484002066 mobile loop; other site 269484002067 roof hairpin; other site 269484002068 hypothetical protein; Reviewed; Region: PRK00024 269484002069 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 269484002070 MPN+ (JAMM) motif; other site 269484002071 Zinc-binding site [ion binding]; other site 269484002072 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 269484002073 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 269484002074 putative active site [active] 269484002075 catalytic triad [active] 269484002076 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 269484002077 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 269484002078 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 269484002079 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 269484002080 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 269484002081 putative active site [active] 269484002082 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 269484002083 Peptidase family M23; Region: Peptidase_M23; pfam01551 269484002084 biotin synthase; Region: bioB; TIGR00433 269484002085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269484002086 FeS/SAM binding site; other site 269484002087 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 269484002088 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 269484002089 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 269484002090 dimerization interface [polypeptide binding]; other site 269484002091 ATP binding site [chemical binding]; other site 269484002092 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 269484002093 dimerization interface [polypeptide binding]; other site 269484002094 ATP binding site [chemical binding]; other site 269484002095 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 269484002096 catalytic center binding site [active] 269484002097 ATP binding site [chemical binding]; other site 269484002098 Peptidase family M48; Region: Peptidase_M48; cl12018 269484002099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 269484002100 binding surface 269484002101 TPR motif; other site 269484002102 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 269484002103 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 269484002104 metal binding site [ion binding]; metal-binding site 269484002105 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 269484002106 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 269484002107 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 269484002108 dimerization interface [polypeptide binding]; other site 269484002109 putative ATP binding site [chemical binding]; other site 269484002110 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 269484002111 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 269484002112 active site 269484002113 DNA binding site [nucleotide binding] 269484002114 Int/Topo IB signature motif; other site 269484002115 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14620 269484002116 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 269484002117 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 269484002118 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 269484002119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269484002120 active site 269484002121 phosphorylation site [posttranslational modification] 269484002122 intermolecular recognition site; other site 269484002123 dimerization interface [polypeptide binding]; other site 269484002124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269484002125 Walker A motif; other site 269484002126 ATP binding site [chemical binding]; other site 269484002127 Walker B motif; other site 269484002128 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 269484002129 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 269484002130 Cell division protein FtsQ; Region: FtsQ; pfam03799 269484002131 glutathione synthetase; Provisional; Region: PRK05246 269484002132 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 269484002133 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 269484002134 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 269484002135 BON domain; Region: BON; pfam04972 269484002136 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 269484002137 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 269484002138 dimer interface [polypeptide binding]; other site 269484002139 anticodon binding site; other site 269484002140 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 269484002141 homodimer interface [polypeptide binding]; other site 269484002142 motif 1; other site 269484002143 active site 269484002144 motif 2; other site 269484002145 GAD domain; Region: GAD; pfam02938 269484002146 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 269484002147 active site 269484002148 motif 3; other site 269484002149 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 269484002150 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 269484002151 motif II; other site 269484002152 RDD family; Region: RDD; pfam06271 269484002153 pyruvate phosphate dikinase; Provisional; Region: PRK09279 269484002154 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 269484002155 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 269484002156 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 269484002157 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 269484002158 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 269484002159 Cytochrome c2 [Energy production and conversion]; Region: COG3474 269484002160 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 269484002161 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14187 269484002162 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 269484002163 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 269484002164 homodimer interface [polypeptide binding]; other site 269484002165 NADP binding site [chemical binding]; other site 269484002166 substrate binding site [chemical binding]; other site 269484002167 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 269484002168 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 269484002169 catalytic site [active] 269484002170 G-X2-G-X-G-K; other site 269484002171 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 269484002172 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 269484002173 RuvA N terminal domain; Region: RuvA_N; pfam01330 269484002174 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 269484002175 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 269484002176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269484002177 Walker A motif; other site 269484002178 ATP binding site [chemical binding]; other site 269484002179 Walker B motif; other site 269484002180 arginine finger; other site 269484002181 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 269484002182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269484002183 Major Facilitator Superfamily; Region: MFS_1; pfam07690 269484002184 putative substrate translocation pore; other site 269484002185 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 269484002186 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 269484002187 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 269484002188 catalytic loop [active] 269484002189 iron binding site [ion binding]; other site 269484002190 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 269484002191 L-aspartate oxidase; Provisional; Region: PRK06175 269484002192 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 269484002193 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 269484002194 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 269484002195 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269484002196 Walker A/P-loop; other site 269484002197 ATP binding site [chemical binding]; other site 269484002198 Q-loop/lid; other site 269484002199 ABC transporter signature motif; other site 269484002200 Walker B; other site 269484002201 D-loop; other site 269484002202 H-loop/switch region; other site 269484002203 Frataxin-like domain; Region: Frataxin_Cyay; pfam01491 269484002204 putative iron binding site [ion binding]; other site 269484002205 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 269484002206 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 269484002207 dimer interface [polypeptide binding]; other site 269484002208 active site 269484002209 glycine-pyridoxal phosphate binding site [chemical binding]; other site 269484002210 folate binding site [chemical binding]; other site 269484002211 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 269484002212 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 269484002213 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 269484002214 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 269484002215 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 269484002216 Colicin V production protein; Region: Colicin_V; pfam02674 269484002217 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 269484002218 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 269484002219 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 269484002220 DNA repair protein RadA; Provisional; Region: PRK11823 269484002221 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 269484002222 Walker A motif; other site 269484002223 ATP binding site [chemical binding]; other site 269484002224 Walker B motif; other site 269484002225 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 269484002226 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 269484002227 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 269484002228 catalytic residues [active] 269484002229 central insert; other site 269484002230 BolA-like protein; Region: BolA; pfam01722 269484002231 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 269484002232 putative GSH binding site [chemical binding]; other site 269484002233 catalytic residues [active] 269484002234 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 269484002235 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 269484002236 nucleotide binding pocket [chemical binding]; other site 269484002237 K-X-D-G motif; other site 269484002238 catalytic site [active] 269484002239 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 269484002240 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 269484002241 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 269484002242 Dimer interface [polypeptide binding]; other site 269484002243 BRCT sequence motif; other site 269484002244 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 269484002245 catalytic site [active] 269484002246 putative active site [active] 269484002247 putative substrate binding site [chemical binding]; other site 269484002248 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 269484002249 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 269484002250 dimerization interface [polypeptide binding]; other site 269484002251 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 269484002252 dimer interface [polypeptide binding]; other site 269484002253 phosphorylation site [posttranslational modification] 269484002254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 269484002255 ATP binding site [chemical binding]; other site 269484002256 Mg2+ binding site [ion binding]; other site 269484002257 G-X-G motif; other site 269484002258 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 269484002259 DNA-binding site [nucleotide binding]; DNA binding site 269484002260 RNA-binding motif; other site 269484002261 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 269484002262 putative NAD(P) binding site [chemical binding]; other site 269484002263 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 269484002264 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 269484002265 trimer interface [polypeptide binding]; other site 269484002266 active site 269484002267 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 269484002268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 269484002269 Walker A/P-loop; other site 269484002270 ATP binding site [chemical binding]; other site 269484002271 Q-loop/lid; other site 269484002272 ABC transporter signature motif; other site 269484002273 Walker B; other site 269484002274 D-loop; other site 269484002275 H-loop/switch region; other site 269484002276 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 269484002277 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 269484002278 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 269484002279 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 269484002280 catalytic residues [active] 269484002281 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 269484002282 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 269484002283 dimer interface [polypeptide binding]; other site 269484002284 motif 1; other site 269484002285 active site 269484002286 motif 2; other site 269484002287 motif 3; other site 269484002288 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 269484002289 anticodon binding site; other site 269484002290 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 269484002291 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 269484002292 ATP binding site [chemical binding]; other site 269484002293 active site 269484002294 substrate binding site [chemical binding]; other site 269484002295 heat shock protein 70; Region: dnaK; CHL00094 269484002296 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 269484002297 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 269484002298 active site 269484002299 DNA binding site [nucleotide binding] 269484002300 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 269484002301 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 269484002302 ribosome recycling factor; Reviewed; Region: frr; PRK00083 269484002303 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 269484002304 hinge region; other site 269484002305 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 269484002306 putative nucleotide binding site [chemical binding]; other site 269484002307 uridine monophosphate binding site [chemical binding]; other site 269484002308 homohexameric interface [polypeptide binding]; other site 269484002309 Protein of unknown function; Region: DUF3971; pfam13116 269484002310 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 269484002311 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 269484002312 RNA/DNA hybrid binding site [nucleotide binding]; other site 269484002313 active site 269484002314 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 269484002315 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 269484002316 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 269484002317 ATP binding site [chemical binding]; other site 269484002318 putative Mg++ binding site [ion binding]; other site 269484002319 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 269484002320 nucleotide binding region [chemical binding]; other site 269484002321 ATP-binding site [chemical binding]; other site 269484002322 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 269484002323 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 269484002324 Lumazine binding domain; Region: Lum_binding; pfam00677 269484002325 Lumazine binding domain; Region: Lum_binding; pfam00677 269484002326 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 269484002327 FMN binding site [chemical binding]; other site 269484002328 substrate binding site [chemical binding]; other site 269484002329 putative catalytic residue [active] 269484002330 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 269484002331 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 269484002332 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 269484002333 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 269484002334 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 269484002335 catalytic residues [active] 269484002336 preprotein translocase subunit SecB; Validated; Region: PRK05751 269484002337 SecA binding site; other site 269484002338 Preprotein binding site; other site 269484002339 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 269484002340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 269484002341 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 269484002342 putative substrate translocation pore; other site 269484002343 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 269484002344 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 269484002345 TMP-binding site; other site 269484002346 ATP-binding site [chemical binding]; other site 269484002347 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 269484002348 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 269484002349 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 269484002350 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 269484002351 ATP-NAD kinase; Region: NAD_kinase; pfam01513 269484002352 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 269484002353 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 269484002354 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 269484002355 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 269484002356 active site 269484002357 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 269484002358 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 269484002359 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 269484002360 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 269484002361 tetramer interface [polypeptide binding]; other site 269484002362 TPP-binding site [chemical binding]; other site 269484002363 heterodimer interface [polypeptide binding]; other site 269484002364 phosphorylation loop region [posttranslational modification] 269484002365 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 269484002366 VirB7 interaction site; other site 269484002367 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 269484002368 catalytic residues [active] 269484002369 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 269484002370 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 269484002371 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 269484002372 FeS/SAM binding site; other site 269484002373 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 269484002374 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 269484002375 Predicted permeases [General function prediction only]; Region: COG0679 269484002376 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 269484002377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269484002378 S-adenosylmethionine binding site [chemical binding]; other site 269484002379 SurA N-terminal domain; Region: SurA_N; pfam09312 269484002380 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 269484002381 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 269484002382 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 269484002383 active site 269484002384 HIGH motif; other site 269484002385 nucleotide binding site [chemical binding]; other site 269484002386 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 269484002387 active site 269484002388 KMSKS motif; other site 269484002389 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 269484002390 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 269484002391 ThiS interaction site; other site 269484002392 putative active site [active] 269484002393 tetramer interface [polypeptide binding]; other site 269484002394 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 269484002395 thiS-thiF/thiG interaction site; other site 269484002396 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 269484002397 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 269484002398 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 269484002399 HSP70 interaction site [polypeptide binding]; other site 269484002400 transcription termination factor Rho; Provisional; Region: rho; PRK09376 269484002401 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 269484002402 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 269484002403 RNA binding site [nucleotide binding]; other site 269484002404 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 269484002405 multimer interface [polypeptide binding]; other site 269484002406 Walker A motif; other site 269484002407 ATP binding site [chemical binding]; other site 269484002408 Walker B motif; other site 269484002409 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 269484002410 active site 269484002411 HslU subunit interaction site [polypeptide binding]; other site 269484002412 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 269484002413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269484002414 Walker A motif; other site 269484002415 ATP binding site [chemical binding]; other site 269484002416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269484002417 Walker B motif; other site 269484002418 arginine finger; other site 269484002419 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 269484002420 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 269484002421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269484002422 S-adenosylmethionine binding site [chemical binding]; other site 269484002423 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 269484002424 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 269484002425 active site 269484002426 HIGH motif; other site 269484002427 KMSKS motif; other site 269484002428 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 269484002429 tRNA binding surface [nucleotide binding]; other site 269484002430 anticodon binding site; other site 269484002431 aspartate kinase; Reviewed; Region: PRK06635 269484002432 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 269484002433 putative nucleotide binding site [chemical binding]; other site 269484002434 putative catalytic residues [active] 269484002435 putative Mg ion binding site [ion binding]; other site 269484002436 putative aspartate binding site [chemical binding]; other site 269484002437 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 269484002438 putative allosteric regulatory site; other site 269484002439 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 269484002440 putative allosteric regulatory residue; other site 269484002441 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 269484002442 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 269484002443 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 269484002444 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 269484002445 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 269484002446 Subunit I/III interface [polypeptide binding]; other site 269484002447 D-pathway; other site 269484002448 Subunit I/VIIc interface [polypeptide binding]; other site 269484002449 Subunit I/IV interface [polypeptide binding]; other site 269484002450 Subunit I/II interface [polypeptide binding]; other site 269484002451 Low-spin heme (heme a) binding site [chemical binding]; other site 269484002452 Subunit I/VIIa interface [polypeptide binding]; other site 269484002453 Subunit I/VIa interface [polypeptide binding]; other site 269484002454 Dimer interface; other site 269484002455 Putative water exit pathway; other site 269484002456 Binuclear center (heme a3/CuB) [ion binding]; other site 269484002457 K-pathway; other site 269484002458 Subunit I/Vb interface [polypeptide binding]; other site 269484002459 Putative proton exit pathway; other site 269484002460 Subunit I/VIb interface; other site 269484002461 Subunit I/VIc interface [polypeptide binding]; other site 269484002462 Electron transfer pathway; other site 269484002463 Subunit I/VIIIb interface [polypeptide binding]; other site 269484002464 Subunit I/VIIb interface [polypeptide binding]; other site 269484002465 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 269484002466 UbiA prenyltransferase family; Region: UbiA; pfam01040 269484002467 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 269484002468 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 269484002469 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 269484002470 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 269484002471 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 269484002472 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 269484002473 Preprotein translocase subunit; Region: YajC; pfam02699 269484002474 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 269484002475 DNA polymerase III subunit beta; Validated; Region: PRK05643 269484002476 putative DNA binding surface [nucleotide binding]; other site 269484002477 dimer interface [polypeptide binding]; other site 269484002478 beta-clamp/clamp loader binding surface; other site 269484002479 beta-clamp/translesion DNA polymerase binding surface; other site 269484002480 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 269484002481 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 269484002482 catalytic site [active] 269484002483 putative active site [active] 269484002484 putative substrate binding site [chemical binding]; other site 269484002485 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 269484002486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 269484002487 active site 269484002488 phosphorylation site [posttranslational modification] 269484002489 intermolecular recognition site; other site 269484002490 dimerization interface [polypeptide binding]; other site 269484002491 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 269484002492 DNA binding site [nucleotide binding] 269484002493 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269484002494 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269484002495 non-specific DNA binding site [nucleotide binding]; other site 269484002496 salt bridge; other site 269484002497 sequence-specific DNA binding site [nucleotide binding]; other site 269484002498 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 269484002499 Predicted transcriptional regulator [Transcription]; Region: COG2932 269484002500 Catalytic site [active] 269484002501 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 269484002502 dimer interface [polypeptide binding]; other site 269484002503 substrate binding site [chemical binding]; other site 269484002504 metal binding sites [ion binding]; metal-binding site 269484002505 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 269484002506 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 269484002507 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 269484002508 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 269484002509 23S rRNA interface [nucleotide binding]; other site 269484002510 L3 interface [polypeptide binding]; other site 269484002511 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 269484002512 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 269484002513 Domain of unknown function DUF59; Region: DUF59; pfam01883 269484002514 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 269484002515 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 269484002516 Walker A motif; other site 269484002517 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 269484002518 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 269484002519 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269484002520 active site 269484002521 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 269484002522 aconitate hydratase; Validated; Region: PRK09277 269484002523 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 269484002524 substrate binding site [chemical binding]; other site 269484002525 ligand binding site [chemical binding]; other site 269484002526 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 269484002527 substrate binding site [chemical binding]; other site 269484002528 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 269484002529 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 269484002530 ATP-grasp domain; Region: ATP-grasp; pfam02222 269484002531 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002532 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002533 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002534 Domain of unknown function (DUF336); Region: DUF336; cl01249 269484002535 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 269484002536 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 269484002537 TrbC/VIRB2 family; Region: TrbC; pfam04956 269484002538 TrbC/VIRB2 family; Region: TrbC; pfam04956 269484002539 TrbC/VIRB2 family; Region: TrbC; pfam04956 269484002540 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 269484002541 HflK protein; Region: hflK; TIGR01933 269484002542 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 269484002543 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 269484002544 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 269484002545 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 269484002546 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 269484002547 protein binding site [polypeptide binding]; other site 269484002548 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 269484002549 protein binding site [polypeptide binding]; other site 269484002550 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 269484002551 ribonuclease III; Reviewed; Region: rnc; PRK00102 269484002552 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 269484002553 dimerization interface [polypeptide binding]; other site 269484002554 active site 269484002555 metal binding site [ion binding]; metal-binding site 269484002556 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 269484002557 dsRNA binding site [nucleotide binding]; other site 269484002558 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 269484002559 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 269484002560 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 269484002561 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 269484002562 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 269484002563 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 269484002564 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 269484002565 lipoprotein signal peptidase; Provisional; Region: PRK14787 269484002566 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 269484002567 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 269484002568 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 269484002569 active site 269484002570 Riboflavin kinase; Region: Flavokinase; smart00904 269484002571 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 269484002572 GSH binding site [chemical binding]; other site 269484002573 catalytic residues [active] 269484002574 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 269484002575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 269484002576 S-adenosylmethionine binding site [chemical binding]; other site 269484002577 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 269484002578 active site 269484002579 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 269484002580 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 269484002581 E3 interaction surface; other site 269484002582 lipoyl attachment site [posttranslational modification]; other site 269484002583 e3 binding domain; Region: E3_binding; pfam02817 269484002584 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 269484002585 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 269484002586 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 269484002587 trimer interface [polypeptide binding]; other site 269484002588 putative metal binding site [ion binding]; other site 269484002589 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 269484002590 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 269484002591 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 269484002592 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 269484002593 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 269484002594 DsbD alpha interface [polypeptide binding]; other site 269484002595 catalytic residues [active] 269484002596 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 269484002597 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 269484002598 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 269484002599 active site 269484002600 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 269484002601 protein binding site [polypeptide binding]; other site 269484002602 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 269484002603 putative substrate binding region [chemical binding]; other site 269484002604 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 269484002605 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 269484002606 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 269484002607 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 269484002608 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 269484002609 Surface antigen; Region: Bac_surface_Ag; pfam01103 269484002610 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 269484002611 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 269484002612 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 269484002613 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 269484002614 purine monophosphate binding site [chemical binding]; other site 269484002615 dimer interface [polypeptide binding]; other site 269484002616 putative catalytic residues [active] 269484002617 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 269484002618 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 269484002619 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 269484002620 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 269484002621 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 269484002622 Putative proton exit pathway; other site 269484002623 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 269484002624 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 269484002625 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 269484002626 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 269484002627 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 269484002628 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 269484002629 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 269484002630 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 269484002631 active site 269484002632 metal binding site [ion binding]; metal-binding site 269484002633 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 269484002634 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 269484002635 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 269484002636 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 269484002637 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 269484002638 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 269484002639 cell division protein FtsA; Region: ftsA; TIGR01174 269484002640 Cell division protein FtsA; Region: FtsA; smart00842 269484002641 Cell division protein FtsA; Region: FtsA; pfam14450 269484002642 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 269484002643 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 269484002644 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 269484002645 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 269484002646 Ligand Binding Site [chemical binding]; other site 269484002647 FtsH Extracellular; Region: FtsH_ext; pfam06480 269484002648 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 269484002649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269484002650 Walker A motif; other site 269484002651 ATP binding site [chemical binding]; other site 269484002652 Walker B motif; other site 269484002653 arginine finger; other site 269484002654 Peptidase family M41; Region: Peptidase_M41; pfam01434 269484002655 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 269484002656 Zinc-finger domain; Region: zf-CHCC; cl01821 269484002657 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 269484002658 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 269484002659 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 269484002660 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 269484002661 ATP binding site [chemical binding]; other site 269484002662 substrate interface [chemical binding]; other site 269484002663 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 269484002664 active site 269484002665 recombinase A; Provisional; Region: recA; PRK09354 269484002666 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 269484002667 hexamer interface [polypeptide binding]; other site 269484002668 Walker A motif; other site 269484002669 ATP binding site [chemical binding]; other site 269484002670 Walker B motif; other site 269484002671 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 269484002672 AAA domain; Region: AAA_26; pfam13500 269484002673 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 269484002674 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 269484002675 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 269484002676 isocitrate dehydrogenase; Validated; Region: PRK09222 269484002677 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 269484002678 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 269484002679 DHH family; Region: DHH; pfam01368 269484002680 DHHA1 domain; Region: DHHA1; pfam02272 269484002681 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 269484002682 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 269484002683 active site 269484002684 NTP binding site [chemical binding]; other site 269484002685 metal binding triad [ion binding]; metal-binding site 269484002686 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 269484002687 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 269484002688 active site 269484002689 multimer interface [polypeptide binding]; other site 269484002690 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 269484002691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 269484002692 non-specific DNA binding site [nucleotide binding]; other site 269484002693 salt bridge; other site 269484002694 sequence-specific DNA binding site [nucleotide binding]; other site 269484002695 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002696 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002697 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002698 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002699 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002700 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002701 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002702 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002703 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002704 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002705 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002706 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002707 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002708 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002709 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002710 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002711 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002712 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002713 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002714 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002715 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002716 Surface antigen; Region: Surface_Ag_2; pfam01617 269484002717 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 269484002718 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 269484002719 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 269484002720 SEC-C motif; Region: SEC-C; pfam02810 269484002721 cell division protein FtsZ; Validated; Region: PRK09330 269484002722 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 269484002723 nucleotide binding site [chemical binding]; other site 269484002724 SulA interaction site; other site 269484002725 EVE domain; Region: EVE; pfam01878 269484002726 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 269484002727 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 269484002728 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 269484002729 P-loop; other site 269484002730 Magnesium ion binding site [ion binding]; other site 269484002731 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 269484002732 Magnesium ion binding site [ion binding]; other site 269484002733 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 269484002734 ParB-like nuclease domain; Region: ParB; smart00470 269484002735 KorB domain; Region: KorB; pfam08535 269484002736 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14592 269484002737 RimM N-terminal domain; Region: RimM; pfam01782 269484002738 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 269484002739 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 269484002740 Competence-damaged protein; Region: CinA; pfam02464 269484002741 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 269484002742 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 269484002743 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 269484002744 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 269484002745 active site 269484002746 dimer interface [polypeptide binding]; other site 269484002747 motif 1; other site 269484002748 motif 2; other site 269484002749 motif 3; other site 269484002750 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 269484002751 anticodon binding site; other site 269484002752 translation initiation factor IF-3; Region: infC; TIGR00168 269484002753 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 269484002754 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 269484002755 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 269484002756 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 269484002757 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 269484002758 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 269484002759 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 269484002760 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 269484002761 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 269484002762 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 269484002763 conserved cys residue [active] 269484002764 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 269484002765 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 269484002766 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14964 269484002767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 269484002768 Walker A motif; other site 269484002769 ATP binding site [chemical binding]; other site 269484002770 Walker B motif; other site 269484002771 arginine finger; other site 269484002772 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 269484002773 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 269484002774 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 269484002775 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 269484002776 S-adenosylmethionine synthetase; Validated; Region: PRK05250 269484002777 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 269484002778 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 269484002779 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773