-- dump date 20140619_070543 -- class Genbank::misc_feature -- table misc_feature_note -- id note 445932000001 Response regulator receiver domain; Region: Response_reg; pfam00072 445932000002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 445932000003 active site 445932000004 phosphorylation site [posttranslational modification] 445932000005 intermolecular recognition site; other site 445932000006 dimerization interface [polypeptide binding]; other site 445932000007 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 445932000008 DnaA N-terminal domain; Region: DnaA_N; pfam11638 445932000009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445932000010 Walker A motif; other site 445932000011 ATP binding site [chemical binding]; other site 445932000012 Walker B motif; other site 445932000013 arginine finger; other site 445932000014 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 445932000015 DnaA box-binding interface [nucleotide binding]; other site 445932000016 DNA polymerase III subunit beta; Validated; Region: PRK05643 445932000017 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 445932000018 putative DNA binding surface [nucleotide binding]; other site 445932000019 dimer interface [polypeptide binding]; other site 445932000020 beta-clamp/clamp loader binding surface; other site 445932000021 beta-clamp/translesion DNA polymerase binding surface; other site 445932000022 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 445932000023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 445932000024 ATP binding site [chemical binding]; other site 445932000025 Mg2+ binding site [ion binding]; other site 445932000026 G-X-G motif; other site 445932000027 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 445932000028 anchoring element; other site 445932000029 dimer interface [polypeptide binding]; other site 445932000030 ATP binding site [chemical binding]; other site 445932000031 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 445932000032 active site 445932000033 putative metal-binding site [ion binding]; other site 445932000034 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 445932000035 DNA gyrase subunit A; Validated; Region: PRK05560 445932000036 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 445932000037 CAP-like domain; other site 445932000038 active site 445932000039 primary dimer interface [polypeptide binding]; other site 445932000040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 445932000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 445932000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 445932000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 445932000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 445932000045 T5orf172 domain; Region: T5orf172; pfam10544 445932000046 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 445932000047 Rubrerythrin [Energy production and conversion]; Region: COG1592 445932000048 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 445932000049 binuclear metal center [ion binding]; other site 445932000050 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 445932000051 iron binding site [ion binding]; other site 445932000052 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 445932000053 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 445932000054 dimer interface [polypeptide binding]; other site 445932000055 catalytic triad [active] 445932000056 peroxidatic and resolving cysteines [active] 445932000057 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 445932000058 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 445932000059 non-heme iron binding site [ion binding]; other site 445932000060 dimer interface [polypeptide binding]; other site 445932000061 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 445932000062 non-heme iron binding site [ion binding]; other site 445932000063 dimer interface [polypeptide binding]; other site 445932000064 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 445932000065 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 445932000066 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 445932000067 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 445932000068 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 445932000069 Rubredoxin; Region: Rubredoxin; pfam00301 445932000070 iron binding site [ion binding]; other site 445932000071 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 445932000072 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 445932000073 Catalytic site [active] 445932000074 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 445932000075 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 445932000076 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 445932000077 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 445932000078 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 445932000079 active site 445932000080 catalytic site [active] 445932000081 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 445932000082 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 445932000083 oligomer interface [polypeptide binding]; other site 445932000084 Cl binding site [ion binding]; other site 445932000085 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 445932000086 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 445932000087 active site 445932000088 catalytic site [active] 445932000089 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 445932000090 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 445932000091 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 445932000092 putative active site [active] 445932000093 PhoH-like protein; Region: PhoH; pfam02562 445932000094 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 445932000095 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 445932000096 active site 445932000097 Int/Topo IB signature motif; other site 445932000098 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 445932000099 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 445932000100 dimer interface [polypeptide binding]; other site 445932000101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 445932000102 catalytic residue [active] 445932000103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932000104 binding surface 445932000105 TPR motif; other site 445932000106 Tetratricopeptide repeat; Region: TPR_12; pfam13424 445932000107 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 445932000108 substrate binding pocket [chemical binding]; other site 445932000109 catalytic residues [active] 445932000110 substrate-Mg2+ binding site; other site 445932000111 aspartate-rich region 1; other site 445932000112 aspartate-rich region 2; other site 445932000113 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 445932000114 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 445932000115 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 445932000116 motif 1; other site 445932000117 active site 445932000118 motif 2; other site 445932000119 motif 3; other site 445932000120 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 445932000121 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 445932000122 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 445932000123 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 445932000124 hypothetical protein; Provisional; Region: PRK10649 445932000125 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 445932000126 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 445932000127 tandem repeat interface [polypeptide binding]; other site 445932000128 oligomer interface [polypeptide binding]; other site 445932000129 active site residues [active] 445932000130 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 445932000131 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 445932000132 dimer interface [polypeptide binding]; other site 445932000133 active site 445932000134 catalytic residue [active] 445932000135 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 445932000136 nucleotide binding site [chemical binding]; other site 445932000137 substrate binding site [chemical binding]; other site 445932000138 Aspartate-semialdehyde dehydrogenase [Amino acid transport and metabolism]; Region: Asd; COG0136 445932000139 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 445932000140 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 445932000141 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 445932000142 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 445932000143 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 445932000144 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 445932000145 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 445932000146 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 445932000147 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 445932000148 RNA binding surface [nucleotide binding]; other site 445932000149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 445932000150 S-adenosylmethionine binding site [chemical binding]; other site 445932000151 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 445932000152 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 445932000153 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 445932000154 generic binding surface II; other site 445932000155 generic binding surface I; other site 445932000156 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 445932000157 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 445932000158 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 445932000159 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 445932000160 Uncharacterized conserved protein [Function unknown]; Region: COG1543 445932000161 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 445932000162 active site 445932000163 substrate binding site [chemical binding]; other site 445932000164 catalytic site [active] 445932000165 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 445932000166 FAD binding domain; Region: FAD_binding_4; pfam01565 445932000167 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 445932000168 FAD binding domain; Region: FAD_binding_4; pfam01565 445932000169 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 445932000170 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 445932000171 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 445932000172 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 445932000173 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 445932000174 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 445932000175 Zn2+ binding site [ion binding]; other site 445932000176 Mg2+ binding site [ion binding]; other site 445932000177 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 445932000178 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 445932000179 ATP binding site [chemical binding]; other site 445932000180 putative Mg++ binding site [ion binding]; other site 445932000181 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 445932000182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 445932000183 nucleotide binding region [chemical binding]; other site 445932000184 ATP-binding site [chemical binding]; other site 445932000185 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 445932000186 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 445932000187 putative active site [active] 445932000188 catalytic triad [active] 445932000189 putative dimer interface [polypeptide binding]; other site 445932000190 peptide chain release factor 2; Validated; Region: prfB; PRK00578 445932000191 This domain is found in peptide chain release factors; Region: PCRF; smart00937 445932000192 RF-1 domain; Region: RF-1; pfam00472 445932000193 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 445932000194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 445932000195 FeS/SAM binding site; other site 445932000196 HemN C-terminal domain; Region: HemN_C; pfam06969 445932000197 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 445932000198 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 445932000199 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 445932000200 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 445932000201 dimer interface [polypeptide binding]; other site 445932000202 putative anticodon binding site; other site 445932000203 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 445932000204 motif 1; other site 445932000205 dimer interface [polypeptide binding]; other site 445932000206 active site 445932000207 motif 2; other site 445932000208 motif 3; other site 445932000209 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932000210 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 445932000211 homodimer interface [polypeptide binding]; other site 445932000212 metal binding site [ion binding]; metal-binding site 445932000213 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 445932000214 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 445932000215 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 445932000216 ligand binding site; other site 445932000217 oligomer interface; other site 445932000218 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 445932000219 dimer interface [polypeptide binding]; other site 445932000220 N-terminal domain interface [polypeptide binding]; other site 445932000221 sulfate 1 binding site; other site 445932000222 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 445932000223 PhoH-like protein; Region: PhoH; pfam02562 445932000224 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 445932000225 Interferon-induced transmembrane protein; Region: CD225; pfam04505 445932000226 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 445932000227 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 445932000228 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 445932000229 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 445932000230 active site 445932000231 Ap6A binding site [chemical binding]; other site 445932000232 nudix motif; other site 445932000233 metal binding site [ion binding]; metal-binding site 445932000234 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 445932000235 EamA-like transporter family; Region: EamA; pfam00892 445932000236 muropeptide transporter; Reviewed; Region: ampG; PRK11902 445932000237 muropeptide transporter; Validated; Region: ampG; cl17669 445932000238 ribosomal protein L28; Region: L28; TIGR00009 445932000239 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 445932000240 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 445932000241 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 445932000242 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 445932000243 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 445932000244 Surface antigen; Region: Bac_surface_Ag; pfam01103 445932000245 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 445932000246 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 445932000247 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 445932000248 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 445932000249 trimer interface [polypeptide binding]; other site 445932000250 active site 445932000251 UDP-GlcNAc binding site [chemical binding]; other site 445932000252 lipid binding site [chemical binding]; lipid-binding site 445932000253 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 445932000254 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 445932000255 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 445932000256 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 445932000257 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 445932000258 active site 445932000259 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 445932000260 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 445932000261 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 445932000262 active site 445932000263 HIGH motif; other site 445932000264 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 445932000265 active site 445932000266 KMSKS motif; other site 445932000267 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 445932000268 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 445932000269 putative active site [active] 445932000270 putative metal binding site [ion binding]; other site 445932000271 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 445932000272 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 445932000273 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 445932000274 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 445932000275 Response regulator receiver domain; Region: Response_reg; pfam00072 445932000276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 445932000277 active site 445932000278 phosphorylation site [posttranslational modification] 445932000279 intermolecular recognition site; other site 445932000280 dimerization interface [polypeptide binding]; other site 445932000281 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 445932000282 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 445932000283 metal binding site [ion binding]; metal-binding site 445932000284 active site 445932000285 I-site; other site 445932000286 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 445932000287 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 445932000288 Ligand Binding Site [chemical binding]; other site 445932000289 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 445932000290 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 445932000291 GTPase CgtA; Reviewed; Region: obgE; PRK12297 445932000292 GTP1/OBG; Region: GTP1_OBG; pfam01018 445932000293 Obg GTPase; Region: Obg; cd01898 445932000294 G1 box; other site 445932000295 GTP/Mg2+ binding site [chemical binding]; other site 445932000296 Switch I region; other site 445932000297 G2 box; other site 445932000298 G3 box; other site 445932000299 Switch II region; other site 445932000300 G4 box; other site 445932000301 G5 box; other site 445932000302 Obg family GTPase CgtA, C-terminal extension; Region: Obg_CgtA_exten; TIGR03595 445932000303 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932000304 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 445932000305 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932000306 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 445932000307 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 445932000308 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 445932000309 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 445932000310 nucleotide binding site [chemical binding]; other site 445932000311 GrpE; Region: GrpE; pfam01025 445932000312 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 445932000313 dimer interface [polypeptide binding]; other site 445932000314 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 445932000315 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 445932000316 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 445932000317 active site 445932000318 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 445932000319 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 445932000320 Zn2+ binding site [ion binding]; other site 445932000321 Mg2+ binding site [ion binding]; other site 445932000322 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 445932000323 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 445932000324 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 445932000325 active site 445932000326 (T/H)XGH motif; other site 445932000327 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 445932000328 nucleoside/Zn binding site; other site 445932000329 dimer interface [polypeptide binding]; other site 445932000330 catalytic motif [active] 445932000331 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 445932000332 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 445932000333 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 445932000334 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 445932000335 active site 445932000336 cell surface protein SprA; Region: surface_SprA; TIGR04189 445932000337 cell surface protein SprA; Region: surface_SprA; TIGR04189 445932000338 cell surface protein SprA; Region: surface_SprA; TIGR04189 445932000339 Predicted permeases [General function prediction only]; Region: COG0795 445932000340 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 445932000341 Predicted permeases [General function prediction only]; Region: COG0795 445932000342 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 445932000343 Response regulator receiver domain; Region: Response_reg; pfam00072 445932000344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 445932000345 active site 445932000346 phosphorylation site [posttranslational modification] 445932000347 intermolecular recognition site; other site 445932000348 dimerization interface [polypeptide binding]; other site 445932000349 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 445932000350 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 445932000351 active site 445932000352 substrate binding site [chemical binding]; other site 445932000353 metal binding site [ion binding]; metal-binding site 445932000354 YacP-like NYN domain; Region: NYN_YacP; cl01491 445932000355 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 445932000356 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 445932000357 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 445932000358 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 445932000359 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 445932000360 active site 445932000361 metal binding site [ion binding]; metal-binding site 445932000362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 445932000363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 445932000364 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 445932000365 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 445932000366 E3 interaction surface; other site 445932000367 lipoyl attachment site [posttranslational modification]; other site 445932000368 HlyD family secretion protein; Region: HlyD_3; pfam13437 445932000369 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 445932000370 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 445932000371 30S subunit binding site; other site 445932000372 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 445932000373 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 445932000374 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 445932000375 Hpr binding site; other site 445932000376 active site 445932000377 homohexamer subunit interaction site [polypeptide binding]; other site 445932000378 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 445932000379 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 445932000380 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 445932000381 active pocket/dimerization site; other site 445932000382 active site 445932000383 phosphorylation site [posttranslational modification] 445932000384 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 445932000385 active site 445932000386 phosphorylation site [posttranslational modification] 445932000387 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 445932000388 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 445932000389 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 445932000390 dimerization domain swap beta strand [polypeptide binding]; other site 445932000391 regulatory protein interface [polypeptide binding]; other site 445932000392 active site 445932000393 regulatory phosphorylation site [posttranslational modification]; other site 445932000394 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 445932000395 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 445932000396 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 445932000397 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 445932000398 GTP-binding protein LepA; Provisional; Region: PRK05433 445932000399 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 445932000400 G1 box; other site 445932000401 putative GEF interaction site [polypeptide binding]; other site 445932000402 GTP/Mg2+ binding site [chemical binding]; other site 445932000403 Switch I region; other site 445932000404 G2 box; other site 445932000405 G3 box; other site 445932000406 Switch II region; other site 445932000407 G4 box; other site 445932000408 G5 box; other site 445932000409 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 445932000410 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 445932000411 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 445932000412 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 445932000413 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 445932000414 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 445932000415 putative active site [active] 445932000416 nucleoside transporter; Region: 2A0110; TIGR00889 445932000417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932000418 putative substrate translocation pore; other site 445932000419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 445932000420 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 445932000421 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 445932000422 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 445932000423 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 445932000424 dimer interface [polypeptide binding]; other site 445932000425 motif 1; other site 445932000426 active site 445932000427 motif 2; other site 445932000428 motif 3; other site 445932000429 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 445932000430 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 445932000431 putative tRNA-binding site [nucleotide binding]; other site 445932000432 B3/4 domain; Region: B3_4; pfam03483 445932000433 tRNA synthetase B5 domain; Region: B5; pfam03484 445932000434 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 445932000435 dimer interface [polypeptide binding]; other site 445932000436 motif 1; other site 445932000437 motif 3; other site 445932000438 motif 2; other site 445932000439 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 445932000440 YCII-related domain; Region: YCII; cl00999 445932000441 Cell division protein ZapA; Region: ZapA; pfam05164 445932000442 recombination factor protein RarA; Reviewed; Region: PRK13342 445932000443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445932000444 Walker A motif; other site 445932000445 ATP binding site [chemical binding]; other site 445932000446 Walker B motif; other site 445932000447 arginine finger; other site 445932000448 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 445932000449 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 445932000450 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 445932000451 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 445932000452 NAD(P) binding site [chemical binding]; other site 445932000453 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 445932000454 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 445932000455 substrate-cofactor binding pocket; other site 445932000456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 445932000457 catalytic residue [active] 445932000458 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 445932000459 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 445932000460 minor groove reading motif; other site 445932000461 helix-hairpin-helix signature motif; other site 445932000462 substrate binding pocket [chemical binding]; other site 445932000463 active site 445932000464 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 445932000465 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 445932000466 triosephosphate isomerase; Provisional; Region: PRK14567 445932000467 substrate binding site [chemical binding]; other site 445932000468 dimer interface [polypeptide binding]; other site 445932000469 catalytic triad [active] 445932000470 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 445932000471 intersubunit interface [polypeptide binding]; other site 445932000472 active site 445932000473 catalytic residue [active] 445932000474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445932000475 Walker A motif; other site 445932000476 ATP binding site [chemical binding]; other site 445932000477 Walker B motif; other site 445932000478 LPP20 lipoprotein; Region: LPP20; cl15824 445932000479 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 445932000480 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 445932000481 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 445932000482 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 445932000483 DNA protecting protein DprA; Region: dprA; TIGR00732 445932000484 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 445932000485 DNA topoisomerase I; Validated; Region: PRK06599 445932000486 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 445932000487 active site 445932000488 interdomain interaction site; other site 445932000489 putative metal-binding site [ion binding]; other site 445932000490 nucleotide binding site [chemical binding]; other site 445932000491 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 445932000492 domain I; other site 445932000493 phosphate binding site [ion binding]; other site 445932000494 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 445932000495 domain III; other site 445932000496 nucleotide binding site [chemical binding]; other site 445932000497 DNA binding groove [nucleotide binding] 445932000498 catalytic site [active] 445932000499 domain II; other site 445932000500 domain IV; other site 445932000501 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 445932000502 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 445932000503 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 445932000504 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 445932000505 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 445932000506 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 445932000507 active site 445932000508 DNA binding site [nucleotide binding] 445932000509 Int/Topo IB signature motif; other site 445932000510 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 445932000511 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 445932000512 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 445932000513 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 445932000514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 445932000515 ATP binding site [chemical binding]; other site 445932000516 putative Mg++ binding site [ion binding]; other site 445932000517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 445932000518 nucleotide binding region [chemical binding]; other site 445932000519 ATP-binding site [chemical binding]; other site 445932000520 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 445932000521 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 445932000522 Transglycosylase; Region: Transgly; pfam00912 445932000523 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 445932000524 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 445932000525 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 445932000526 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 445932000527 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 445932000528 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 445932000529 FAD binding pocket [chemical binding]; other site 445932000530 FAD binding motif [chemical binding]; other site 445932000531 phosphate binding motif [ion binding]; other site 445932000532 beta-alpha-beta structure motif; other site 445932000533 NAD binding pocket [chemical binding]; other site 445932000534 Iron coordination center [ion binding]; other site 445932000535 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 445932000536 substrate binding pocket [chemical binding]; other site 445932000537 substrate-Mg2+ binding site; other site 445932000538 aspartate-rich region 1; other site 445932000539 aspartate-rich region 2; other site 445932000540 RDD family; Region: RDD; pfam06271 445932000541 RDD family; Region: RDD; pfam06271 445932000542 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 445932000543 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 445932000544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 445932000545 dimer interface [polypeptide binding]; other site 445932000546 phosphorylation site [posttranslational modification] 445932000547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 445932000548 ATP binding site [chemical binding]; other site 445932000549 Mg2+ binding site [ion binding]; other site 445932000550 G-X-G motif; other site 445932000551 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 445932000552 active site 445932000553 metal binding site [ion binding]; metal-binding site 445932000554 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 445932000555 Peptidase family M23; Region: Peptidase_M23; pfam01551 445932000556 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 445932000557 SurA N-terminal domain; Region: SurA_N_3; cl07813 445932000558 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 445932000559 substrate binding site [chemical binding]; other site 445932000560 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 445932000561 ATP binding site [chemical binding]; other site 445932000562 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 445932000563 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 445932000564 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 445932000565 DNA binding residues [nucleotide binding] 445932000566 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 445932000567 DALR anticodon binding domain; Region: DALR_1; pfam05746 445932000568 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 445932000569 motif 1; other site 445932000570 dimer interface [polypeptide binding]; other site 445932000571 active site 445932000572 motif 2; other site 445932000573 motif 3; other site 445932000574 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 445932000575 Recombination protein O N terminal; Region: RecO_N; pfam11967 445932000576 Recombination protein O C terminal; Region: RecO_C; pfam02565 445932000577 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 445932000578 MarC family integral membrane protein; Region: MarC; cl00919 445932000579 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 445932000580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 445932000581 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 445932000582 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 445932000583 Staphylococcal nuclease homologues; Region: SNc; smart00318 445932000584 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 445932000585 Catalytic site; other site 445932000586 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 445932000587 Insect allergen related repeat, nitrile-specifier detoxification; Region: Ins_allergen_rp; pfam06757 445932000588 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 445932000589 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 445932000590 GIY-YIG motif/motif A; other site 445932000591 active site 445932000592 catalytic site [active] 445932000593 putative DNA binding site [nucleotide binding]; other site 445932000594 metal binding site [ion binding]; metal-binding site 445932000595 UvrB/uvrC motif; Region: UVR; pfam02151 445932000596 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 445932000597 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 445932000598 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 445932000599 generic binding surface II; other site 445932000600 ssDNA binding site; other site 445932000601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 445932000602 ATP binding site [chemical binding]; other site 445932000603 putative Mg++ binding site [ion binding]; other site 445932000604 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 445932000605 nucleotide binding region [chemical binding]; other site 445932000606 ATP-binding site [chemical binding]; other site 445932000607 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 445932000608 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 445932000609 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 445932000610 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 445932000611 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 445932000612 HIGH motif; other site 445932000613 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 445932000614 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 445932000615 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 445932000616 active site 445932000617 KMSKS motif; other site 445932000618 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 445932000619 tRNA binding surface [nucleotide binding]; other site 445932000620 Lipopolysaccharide-assembly; Region: LptE; pfam04390 445932000621 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 445932000622 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 445932000623 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932000624 GTP-binding protein YchF; Reviewed; Region: PRK09601 445932000625 YchF GTPase; Region: YchF; cd01900 445932000626 G1 box; other site 445932000627 GTP/Mg2+ binding site [chemical binding]; other site 445932000628 Switch I region; other site 445932000629 G2 box; other site 445932000630 Switch II region; other site 445932000631 G3 box; other site 445932000632 G4 box; other site 445932000633 G5 box; other site 445932000634 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 445932000635 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 445932000636 Part of AAA domain; Region: AAA_19; pfam13245 445932000637 Family description; Region: UvrD_C_2; pfam13538 445932000638 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932000639 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 445932000640 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 445932000641 active site 445932000642 PHP Thumb interface [polypeptide binding]; other site 445932000643 metal binding site [ion binding]; metal-binding site 445932000644 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 445932000645 generic binding surface I; other site 445932000646 generic binding surface II; other site 445932000647 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 445932000648 dimer interface [polypeptide binding]; other site 445932000649 ADP-ribose binding site [chemical binding]; other site 445932000650 active site 445932000651 nudix motif; other site 445932000652 metal binding site [ion binding]; metal-binding site 445932000653 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 445932000654 MutS domain I; Region: MutS_I; pfam01624 445932000655 MutS domain II; Region: MutS_II; pfam05188 445932000656 MutS domain III; Region: MutS_III; pfam05192 445932000657 MutS domain V; Region: MutS_V; pfam00488 445932000658 Walker A/P-loop; other site 445932000659 ATP binding site [chemical binding]; other site 445932000660 Q-loop/lid; other site 445932000661 ABC transporter signature motif; other site 445932000662 Walker B; other site 445932000663 D-loop; other site 445932000664 H-loop/switch region; other site 445932000665 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 445932000666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 445932000667 ATP binding site [chemical binding]; other site 445932000668 Mg2+ binding site [ion binding]; other site 445932000669 G-X-G motif; other site 445932000670 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 445932000671 ATP binding site [chemical binding]; other site 445932000672 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 445932000673 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932000674 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 445932000675 putative FMN binding site [chemical binding]; other site 445932000676 NADPH bind site [chemical binding]; other site 445932000677 hypothetical protein; Provisional; Region: PRK10621 445932000678 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 445932000679 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 445932000680 ATP binding site [chemical binding]; other site 445932000681 active site 445932000682 substrate binding site [chemical binding]; other site 445932000683 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 445932000684 N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional; Region: PRK04338 445932000685 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 445932000686 DNA methylase; Region: N6_N4_Mtase; pfam01555 445932000687 DNA methylase; Region: N6_N4_Mtase; cl17433 445932000688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 445932000689 AAA ATPase domain; Region: AAA_15; pfam13175 445932000690 Walker A/P-loop; other site 445932000691 ATP binding site [chemical binding]; other site 445932000692 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 445932000693 putative active site [active] 445932000694 putative metal-binding site [ion binding]; other site 445932000695 Restriction endonuclease [Defense mechanisms]; Region: COG3587 445932000696 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 445932000697 ATP binding site [chemical binding]; other site 445932000698 Helix-turn-helix domain; Region: HTH_17; pfam12728 445932000699 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 445932000700 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 445932000701 catalytic residues [active] 445932000702 catalytic nucleophile [active] 445932000703 Recombinase; Region: Recombinase; pfam07508 445932000704 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 445932000705 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 445932000706 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 445932000707 active site 445932000708 metal binding site [ion binding]; metal-binding site 445932000709 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 445932000710 Uncharacterized conserved protein [Function unknown]; Region: COG0327 445932000711 diaminopimelate aminotransferase; Provisional; Region: PRK13983 445932000712 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650 445932000713 metal binding site [ion binding]; metal-binding site 445932000714 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 445932000715 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 445932000716 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 445932000717 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 445932000718 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 445932000719 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 445932000720 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 445932000721 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 445932000722 Methyltransferase domain; Region: Methyltransf_31; pfam13847 445932000723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 445932000724 S-adenosylmethionine binding site [chemical binding]; other site 445932000725 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 445932000726 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 445932000727 A new structural DNA glycosylase; Region: AlkD_like; cd06561 445932000728 active site 445932000729 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 445932000730 EamA-like transporter family; Region: EamA; pfam00892 445932000731 EamA-like transporter family; Region: EamA; pfam00892 445932000732 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 445932000733 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 445932000734 active site 445932000735 HIGH motif; other site 445932000736 nucleotide binding site [chemical binding]; other site 445932000737 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 445932000738 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 445932000739 active site 445932000740 KMSKS motif; other site 445932000741 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 445932000742 tRNA binding surface [nucleotide binding]; other site 445932000743 anticodon binding site; other site 445932000744 TRL-like protein family; Region: TRL; pfam13146 445932000745 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 445932000746 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 445932000747 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 445932000748 FeS/SAM binding site; other site 445932000749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 445932000750 Bacterial SH3 domain; Region: SH3_4; pfam06347 445932000751 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 445932000752 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 445932000753 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 445932000754 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 445932000755 active site 445932000756 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 445932000757 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 445932000758 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 445932000759 active site 445932000760 catalytic site [active] 445932000761 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 445932000762 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 445932000763 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 445932000764 homodimer interface [polypeptide binding]; other site 445932000765 NADP binding site [chemical binding]; other site 445932000766 substrate binding site [chemical binding]; other site 445932000767 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932000768 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 445932000769 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 445932000770 GTP/Mg2+ binding site [chemical binding]; other site 445932000771 G1 box; other site 445932000772 Switch I region; other site 445932000773 G2 box; other site 445932000774 Switch II region; other site 445932000775 G3 box; other site 445932000776 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 445932000777 G4 box; other site 445932000778 G4 box; other site 445932000779 G5 box; other site 445932000780 G5 box; other site 445932000781 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 445932000782 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 445932000783 substrate binding pocket [chemical binding]; other site 445932000784 chain length determination region; other site 445932000785 substrate-Mg2+ binding site; other site 445932000786 catalytic residues [active] 445932000787 aspartate-rich region 1; other site 445932000788 active site lid residues [active] 445932000789 aspartate-rich region 2; other site 445932000790 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 445932000791 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 445932000792 TPP-binding site; other site 445932000793 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 445932000794 PYR/PP interface [polypeptide binding]; other site 445932000795 dimer interface [polypeptide binding]; other site 445932000796 TPP binding site [chemical binding]; other site 445932000797 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 445932000798 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 445932000799 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 445932000800 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 445932000801 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 445932000802 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 445932000803 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 445932000804 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 445932000805 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 445932000806 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 445932000807 putative homodimer interface [polypeptide binding]; other site 445932000808 putative active site pocket [active] 445932000809 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 445932000810 Methyltransferase domain; Region: Methyltransf_31; pfam13847 445932000811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 445932000812 S-adenosylmethionine binding site [chemical binding]; other site 445932000813 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 445932000814 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 445932000815 active site 445932000816 glutamate racemase; Provisional; Region: PRK00865 445932000817 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 445932000818 phosphopentomutase; Provisional; Region: PRK05362 445932000819 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 445932000820 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 445932000821 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 445932000822 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 445932000823 ABC transporter; Region: ABC_tran; pfam00005 445932000824 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 445932000825 putative oxidoreductase; Provisional; Region: PRK11445 445932000826 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 445932000827 homoserine dehydrogenase; Provisional; Region: PRK06349 445932000828 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 445932000829 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 445932000830 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 445932000831 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 445932000832 conserved cys residue [active] 445932000833 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 445932000834 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 445932000835 homodimer interface [polypeptide binding]; other site 445932000836 substrate-cofactor binding pocket; other site 445932000837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 445932000838 catalytic residue [active] 445932000839 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 445932000840 catalytic core [active] 445932000841 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 445932000842 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 445932000843 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 445932000844 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 445932000845 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 445932000846 active site 445932000847 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 445932000848 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 445932000849 Malic enzyme, N-terminal domain; Region: malic; pfam00390 445932000850 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 445932000851 putative NAD(P) binding site [chemical binding]; other site 445932000852 fumarate hydratase; Provisional; Region: PRK06246 445932000853 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 445932000854 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 445932000855 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 445932000856 dimerization interface [polypeptide binding]; other site 445932000857 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 445932000858 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 445932000859 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 445932000860 active site 445932000861 nucleophile elbow; other site 445932000862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932000863 binding surface 445932000864 TPR motif; other site 445932000865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932000866 binding surface 445932000867 TPR motif; other site 445932000868 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 445932000869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 445932000870 ATP binding site [chemical binding]; other site 445932000871 Mg2+ binding site [ion binding]; other site 445932000872 G-X-G motif; other site 445932000873 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 445932000874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 445932000875 active site 445932000876 phosphorylation site [posttranslational modification] 445932000877 intermolecular recognition site; other site 445932000878 dimerization interface [polypeptide binding]; other site 445932000879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 445932000880 DNA binding residues [nucleotide binding] 445932000881 dimerization interface [polypeptide binding]; other site 445932000882 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 445932000883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 445932000884 S-adenosylmethionine binding site [chemical binding]; other site 445932000885 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 445932000886 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 445932000887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 445932000888 NAD(P) binding site [chemical binding]; other site 445932000889 active site 445932000890 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 445932000891 4Fe-4S binding domain; Region: Fer4; pfam00037 445932000892 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 445932000893 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 445932000894 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 445932000895 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 445932000896 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 445932000897 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 445932000898 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 445932000899 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 445932000900 DNA binding residues [nucleotide binding] 445932000901 DNA primase; Validated; Region: dnaG; PRK05667 445932000902 CHC2 zinc finger; Region: zf-CHC2; pfam01807 445932000903 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 445932000904 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 445932000905 active site 445932000906 metal binding site [ion binding]; metal-binding site 445932000907 interdomain interaction site; other site 445932000908 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 445932000909 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 445932000910 nucleotide binding site/active site [active] 445932000911 HIT family signature motif; other site 445932000912 catalytic residue [active] 445932000913 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 445932000914 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 445932000915 ligand binding site [chemical binding]; other site 445932000916 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 445932000917 Mechanosensitive ion channel; Region: MS_channel; pfam00924 445932000918 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 445932000919 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 445932000920 putative active site [active] 445932000921 putative metal binding site [ion binding]; other site 445932000922 replicative DNA helicase; Region: DnaB; TIGR00665 445932000923 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 445932000924 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 445932000925 Walker A motif; other site 445932000926 ATP binding site [chemical binding]; other site 445932000927 Walker B motif; other site 445932000928 DNA binding loops [nucleotide binding] 445932000929 alanine racemase; Reviewed; Region: alr; PRK00053 445932000930 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 445932000931 active site 445932000932 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 445932000933 dimer interface [polypeptide binding]; other site 445932000934 substrate binding site [chemical binding]; other site 445932000935 catalytic residues [active] 445932000936 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 445932000937 Permease; Region: Permease; pfam02405 445932000938 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 445932000939 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 445932000940 Walker A/P-loop; other site 445932000941 ATP binding site [chemical binding]; other site 445932000942 Q-loop/lid; other site 445932000943 ABC transporter signature motif; other site 445932000944 Walker B; other site 445932000945 D-loop; other site 445932000946 H-loop/switch region; other site 445932000947 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 445932000948 mce related protein; Region: MCE; pfam02470 445932000949 L-aspartate oxidase; Provisional; Region: PRK06175 445932000950 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 445932000951 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 445932000952 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932000953 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 445932000954 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 445932000955 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 445932000956 Autotransporter beta-domain; Region: Autotransporter; smart00869 445932000957 OsmC-like protein; Region: OsmC; pfam02566 445932000958 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 445932000959 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 445932000960 putative NADH binding site [chemical binding]; other site 445932000961 putative active site [active] 445932000962 nudix motif; other site 445932000963 putative metal binding site [ion binding]; other site 445932000964 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 445932000965 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 445932000966 putative active site [active] 445932000967 catalytic site [active] 445932000968 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 445932000969 putative active site [active] 445932000970 catalytic site [active] 445932000971 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 445932000972 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 445932000973 Pirin-related protein [General function prediction only]; Region: COG1741 445932000974 Pirin; Region: Pirin; pfam02678 445932000975 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 445932000976 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932000977 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 445932000978 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 445932000979 Ligand binding site; other site 445932000980 Putative Catalytic site; other site 445932000981 DXD motif; other site 445932000982 Haemolysin-III related; Region: HlyIII; cl03831 445932000983 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 445932000984 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 445932000985 pyruvate phosphate dikinase; Provisional; Region: PRK09279 445932000986 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 445932000987 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 445932000988 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 445932000989 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932000990 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 445932000991 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 445932000992 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 445932000993 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 445932000994 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 445932000995 23S rRNA binding site [nucleotide binding]; other site 445932000996 L21 binding site [polypeptide binding]; other site 445932000997 L13 binding site [polypeptide binding]; other site 445932000998 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932000999 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 445932001000 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 445932001001 Sulfatase; Region: Sulfatase; cl17466 445932001002 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 445932001003 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 445932001004 intersubunit interface [polypeptide binding]; other site 445932001005 active site 445932001006 zinc binding site [ion binding]; other site 445932001007 Na+ binding site [ion binding]; other site 445932001008 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 445932001009 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 445932001010 oligomer interface [polypeptide binding]; other site 445932001011 active site 445932001012 metal binding site [ion binding]; metal-binding site 445932001013 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 445932001014 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 445932001015 TPP-binding site [chemical binding]; other site 445932001016 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 445932001017 PYR/PP interface [polypeptide binding]; other site 445932001018 dimer interface [polypeptide binding]; other site 445932001019 TPP binding site [chemical binding]; other site 445932001020 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 445932001021 trimer interface [polypeptide binding]; other site 445932001022 putative Zn binding site [ion binding]; other site 445932001023 GTPase Era; Reviewed; Region: era; PRK00089 445932001024 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 445932001025 G1 box; other site 445932001026 GTP/Mg2+ binding site [chemical binding]; other site 445932001027 Switch I region; other site 445932001028 G2 box; other site 445932001029 Switch II region; other site 445932001030 G3 box; other site 445932001031 G4 box; other site 445932001032 G5 box; other site 445932001033 NHL repeat; Region: NHL; pfam01436 445932001034 NHL repeat; Region: NHL; pfam01436 445932001035 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 445932001036 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 445932001037 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 445932001038 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 445932001039 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 445932001040 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 445932001041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 445932001042 motif II; other site 445932001043 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 445932001044 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 445932001045 putative substrate binding site [chemical binding]; other site 445932001046 putative ATP binding site [chemical binding]; other site 445932001047 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 445932001048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932001049 putative substrate translocation pore; other site 445932001050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 445932001051 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 445932001052 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 445932001053 active site 445932001054 substrate binding site [chemical binding]; other site 445932001055 metal binding site [ion binding]; metal-binding site 445932001056 enolase; Provisional; Region: eno; PRK00077 445932001057 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 445932001058 dimer interface [polypeptide binding]; other site 445932001059 metal binding site [ion binding]; metal-binding site 445932001060 substrate binding pocket [chemical binding]; other site 445932001061 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 445932001062 Septum formation initiator; Region: DivIC; pfam04977 445932001063 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 445932001064 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 445932001065 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 445932001066 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 445932001067 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 445932001068 RNA binding surface [nucleotide binding]; other site 445932001069 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 445932001070 active site 445932001071 Dopey, N-terminal; Region: Dopey_N; cl04407 445932001072 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 445932001073 Sulfatase; Region: Sulfatase; pfam00884 445932001074 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 445932001075 Peptidase family M48; Region: Peptidase_M48; cl12018 445932001076 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932001077 binding surface 445932001078 TPR motif; other site 445932001079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932001080 binding surface 445932001081 TPR motif; other site 445932001082 Stage II sporulation protein; Region: SpoIID; pfam08486 445932001083 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 445932001084 lipoyl synthase; Provisional; Region: PRK05481 445932001085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 445932001086 FeS/SAM binding site; other site 445932001087 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932001088 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 445932001089 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 445932001090 dimer interface [polypeptide binding]; other site 445932001091 anticodon binding site; other site 445932001092 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 445932001093 homodimer interface [polypeptide binding]; other site 445932001094 motif 1; other site 445932001095 active site 445932001096 motif 2; other site 445932001097 GAD domain; Region: GAD; pfam02938 445932001098 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 445932001099 active site 445932001100 motif 3; other site 445932001101 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 445932001102 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 445932001103 dimer interface [polypeptide binding]; other site 445932001104 motif 1; other site 445932001105 active site 445932001106 motif 2; other site 445932001107 motif 3; other site 445932001108 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 445932001109 anticodon binding site; other site 445932001110 4-alpha-glucanotransferase; Provisional; Region: PRK14508 445932001111 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 445932001112 homotrimer interaction site [polypeptide binding]; other site 445932001113 putative active site [active] 445932001114 HupF/HypC family; Region: HupF_HypC; pfam01455 445932001115 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 445932001116 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 445932001117 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 445932001118 dimerization interface [polypeptide binding]; other site 445932001119 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 445932001120 ATP binding site [chemical binding]; other site 445932001121 Acylphosphatase; Region: Acylphosphatase; pfam00708 445932001122 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 445932001123 HypF finger; Region: zf-HYPF; pfam07503 445932001124 HypF finger; Region: zf-HYPF; pfam07503 445932001125 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 445932001126 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932001127 Peptidase family M48; Region: Peptidase_M48; pfam01435 445932001128 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 445932001129 active site 445932001130 catalytic triad [active] 445932001131 oxyanion hole [active] 445932001132 pantothenate kinase; Reviewed; Region: PRK13321 445932001133 RmuC family; Region: RmuC; pfam02646 445932001134 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 445932001135 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 445932001136 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 445932001137 DNA repair protein RadA; Provisional; Region: PRK11823 445932001138 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 445932001139 Walker A motif/ATP binding site; other site 445932001140 ATP binding site [chemical binding]; other site 445932001141 Walker B motif; other site 445932001142 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 445932001143 RDD family; Region: RDD; pfam06271 445932001144 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 445932001145 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 445932001146 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 445932001147 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 445932001148 active site 445932001149 catalytic residues [active] 445932001150 metal binding site [ion binding]; metal-binding site 445932001151 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 445932001152 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 445932001153 substrate binding site [chemical binding]; other site 445932001154 ligand binding site [chemical binding]; other site 445932001155 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 445932001156 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 445932001157 substrate binding site [chemical binding]; other site 445932001158 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 445932001159 isocitrate dehydrogenase; Validated; Region: PRK06451 445932001160 putative transporter; Provisional; Region: PRK11660 445932001161 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 445932001162 Sulfate transporter family; Region: Sulfate_transp; pfam00916 445932001163 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 445932001164 TPR repeat; Region: TPR_11; pfam13414 445932001165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932001166 binding surface 445932001167 TPR motif; other site 445932001168 TPR repeat; Region: TPR_11; pfam13414 445932001169 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932001170 binding surface 445932001171 Tetratricopeptide repeat; Region: TPR_16; pfam13432 445932001172 TPR motif; other site 445932001173 TPR repeat; Region: TPR_11; pfam13414 445932001174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932001175 binding surface 445932001176 TPR motif; other site 445932001177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932001178 TPR repeat; Region: TPR_11; pfam13414 445932001179 binding surface 445932001180 TPR motif; other site 445932001181 TPR repeat; Region: TPR_11; pfam13414 445932001182 LytB protein; Region: LYTB; cl00507 445932001183 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 445932001184 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 445932001185 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 445932001186 active site 445932001187 ADP/pyrophosphate binding site [chemical binding]; other site 445932001188 dimerization interface [polypeptide binding]; other site 445932001189 allosteric effector site; other site 445932001190 fructose-1,6-bisphosphate binding site; other site 445932001191 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 445932001192 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 445932001193 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 445932001194 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 445932001195 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 445932001196 Walker A/P-loop; other site 445932001197 ATP binding site [chemical binding]; other site 445932001198 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 445932001199 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 445932001200 ABC transporter signature motif; other site 445932001201 Walker B; other site 445932001202 D-loop; other site 445932001203 H-loop/switch region; other site 445932001204 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 445932001205 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 445932001206 active site 445932001207 metal binding site [ion binding]; metal-binding site 445932001208 putative transporter; Provisional; Region: PRK10504 445932001209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932001210 putative substrate translocation pore; other site 445932001211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932001212 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 445932001213 carboxyltransferase (CT) interaction site; other site 445932001214 biotinylation site [posttranslational modification]; other site 445932001215 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 445932001216 active site 445932001217 Quinolinate synthetase A protein; Region: NadA; pfam02445 445932001218 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 445932001219 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 445932001220 dimerization interface [polypeptide binding]; other site 445932001221 active site 445932001222 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 445932001223 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 445932001224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 445932001225 homodimer interface [polypeptide binding]; other site 445932001226 catalytic residue [active] 445932001227 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 445932001228 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 445932001229 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 445932001230 Walker A/P-loop; other site 445932001231 ATP binding site [chemical binding]; other site 445932001232 Q-loop/lid; other site 445932001233 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 445932001234 ABC transporter signature motif; other site 445932001235 Walker B; other site 445932001236 D-loop; other site 445932001237 H-loop/switch region; other site 445932001238 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 445932001239 ATP-NAD kinase; Region: NAD_kinase; pfam01513 445932001240 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 445932001241 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 445932001242 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 445932001243 EamA-like transporter family; Region: EamA; pfam00892 445932001244 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 445932001245 EamA-like transporter family; Region: EamA; pfam00892 445932001246 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 445932001247 EamA-like transporter family; Region: EamA; pfam00892 445932001248 EamA-like transporter family; Region: EamA; pfam00892 445932001249 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 445932001250 Sel1-like repeats; Region: SEL1; smart00671 445932001251 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 445932001252 Sel1-like repeats; Region: SEL1; smart00671 445932001253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 445932001254 binding surface 445932001255 TPR motif; other site 445932001256 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 445932001257 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 445932001258 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 445932001259 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 445932001260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 445932001261 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 445932001262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 445932001263 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 445932001264 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 445932001265 trimerization site [polypeptide binding]; other site 445932001266 active site 445932001267 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 445932001268 NifU-like domain; Region: NifU; cl00484 445932001269 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 445932001270 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 445932001271 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 445932001272 catalytic residue [active] 445932001273 serine O-acetyltransferase; Region: cysE; TIGR01172 445932001274 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 445932001275 trimer interface [polypeptide binding]; other site 445932001276 active site 445932001277 substrate binding site [chemical binding]; other site 445932001278 CoA binding site [chemical binding]; other site 445932001279 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 445932001280 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 445932001281 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 445932001282 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 445932001283 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 445932001284 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 445932001285 tetramer interfaces [polypeptide binding]; other site 445932001286 binuclear metal-binding site [ion binding]; other site 445932001287 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 445932001288 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 445932001289 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 445932001290 Gram-negative bacterial tonB protein; Region: TonB; cl10048 445932001291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 445932001292 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 445932001293 NAD(P) binding site [chemical binding]; other site 445932001294 active site 445932001295 zinc transporter ZupT; Provisional; Region: PRK04201 445932001296 ZIP Zinc transporter; Region: Zip; pfam02535 445932001297 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932001298 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 445932001299 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 445932001300 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 445932001301 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 445932001302 putative fimbrial protein TcfA; Provisional; Region: PRK15308 445932001303 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 445932001304 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 445932001305 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 445932001306 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 445932001307 ligand binding site [chemical binding]; other site 445932001308 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 445932001309 NosL; Region: NosL; cl01769 445932001310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 445932001311 non-specific DNA binding site [nucleotide binding]; other site 445932001312 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 445932001313 salt bridge; other site 445932001314 sequence-specific DNA binding site [nucleotide binding]; other site 445932001315 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 445932001316 RNAase interaction site [polypeptide binding]; other site 445932001317 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 445932001318 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 445932001319 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 445932001320 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 445932001321 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 445932001322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 445932001323 motif II; other site 445932001324 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 445932001325 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 445932001326 dimer interface [polypeptide binding]; other site 445932001327 active site 445932001328 metal binding site [ion binding]; metal-binding site 445932001329 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 445932001330 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 445932001331 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 445932001332 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 445932001333 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 445932001334 PhoU domain; Region: PhoU; pfam01895 445932001335 PhoU domain; Region: PhoU; pfam01895 445932001336 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 445932001337 4Fe-4S binding domain; Region: Fer4; pfam00037 445932001338 4Fe-4S binding domain; Region: Fer4; pfam00037 445932001339 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 445932001340 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 445932001341 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 445932001342 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932001343 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 445932001344 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 445932001345 Found in ATP-dependent protease La (LON); Region: LON; smart00464 445932001346 Found in ATP-dependent protease La (LON); Region: LON; smart00464 445932001347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445932001348 Walker A motif; other site 445932001349 ATP binding site [chemical binding]; other site 445932001350 Walker B motif; other site 445932001351 arginine finger; other site 445932001352 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 445932001353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932001354 binding surface 445932001355 TPR motif; other site 445932001356 Stage II sporulation protein; Region: SpoIID; pfam08486 445932001357 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 445932001358 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 445932001359 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 445932001360 putative ADP-binding pocket [chemical binding]; other site 445932001361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932001362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932001363 Major Facilitator Superfamily; Region: MFS_1; pfam07690 445932001364 putative substrate translocation pore; other site 445932001365 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 445932001366 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 445932001367 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 445932001368 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 445932001369 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 445932001370 Soluble P-type ATPase [General function prediction only]; Region: COG4087 445932001371 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 445932001372 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 445932001373 PLD-like domain; Region: PLDc_2; pfam13091 445932001374 putative active site [active] 445932001375 catalytic site [active] 445932001376 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 445932001377 PLD-like domain; Region: PLDc_2; pfam13091 445932001378 putative active site [active] 445932001379 catalytic site [active] 445932001380 flavoprotein, HI0933 family; Region: TIGR00275 445932001381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 445932001382 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 445932001383 DNA-binding site [nucleotide binding]; DNA binding site 445932001384 RNA-binding motif; other site 445932001385 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 445932001386 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 445932001387 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932001388 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 445932001389 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 445932001390 catalytic residues [active] 445932001391 DNA polymerase I; Provisional; Region: PRK05755 445932001392 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 445932001393 active site 445932001394 metal binding site 1 [ion binding]; metal-binding site 445932001395 putative 5' ssDNA interaction site; other site 445932001396 metal binding site 3; metal-binding site 445932001397 metal binding site 2 [ion binding]; metal-binding site 445932001398 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 445932001399 putative DNA binding site [nucleotide binding]; other site 445932001400 putative metal binding site [ion binding]; other site 445932001401 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 445932001402 active site 445932001403 substrate binding site [chemical binding]; other site 445932001404 catalytic site [active] 445932001405 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 445932001406 active site 445932001407 DNA binding site [nucleotide binding] 445932001408 catalytic site [active] 445932001409 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 445932001410 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 445932001411 CoA-binding site [chemical binding]; other site 445932001412 ATP-binding [chemical binding]; other site 445932001413 transcription termination factor Rho; Provisional; Region: rho; PRK09376 445932001414 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 445932001415 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 445932001416 RNA binding site [nucleotide binding]; other site 445932001417 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 445932001418 multimer interface [polypeptide binding]; other site 445932001419 Walker A motif; other site 445932001420 ATP binding site [chemical binding]; other site 445932001421 Walker B motif; other site 445932001422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 445932001423 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 445932001424 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 445932001425 SpoVG; Region: SpoVG; pfam04026 445932001426 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 445932001427 RuvA N terminal domain; Region: RuvA_N; pfam01330 445932001428 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 445932001429 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 445932001430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445932001431 Walker A motif; other site 445932001432 ATP binding site [chemical binding]; other site 445932001433 Walker B motif; other site 445932001434 arginine finger; other site 445932001435 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 445932001436 Stage II sporulation protein; Region: SpoIID; pfam08486 445932001437 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 445932001438 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 445932001439 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 445932001440 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 445932001441 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 445932001442 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 445932001443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 445932001444 dimer interface [polypeptide binding]; other site 445932001445 phosphorylation site [posttranslational modification] 445932001446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 445932001447 ATP binding site [chemical binding]; other site 445932001448 Mg2+ binding site [ion binding]; other site 445932001449 G-X-G motif; other site 445932001450 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 445932001451 Predicted methyltransferases [General function prediction only]; Region: COG0313 445932001452 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 445932001453 putative SAM binding site [chemical binding]; other site 445932001454 putative homodimer interface [polypeptide binding]; other site 445932001455 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 445932001456 ATP binding site [chemical binding]; other site 445932001457 active site 445932001458 substrate binding site [chemical binding]; other site 445932001459 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 445932001460 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 445932001461 putative active site [active] 445932001462 catalytic triad [active] 445932001463 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 445932001464 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 445932001465 tetramer interface [polypeptide binding]; other site 445932001466 active site 445932001467 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 445932001468 active site 445932001469 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 445932001470 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 445932001471 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 445932001472 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 445932001473 AIR carboxylase; Region: AIRC; pfam00731 445932001474 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 445932001475 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 445932001476 dimerization interface [polypeptide binding]; other site 445932001477 putative ATP binding site [chemical binding]; other site 445932001478 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 445932001479 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 445932001480 active site 445932001481 substrate binding site [chemical binding]; other site 445932001482 cosubstrate binding site; other site 445932001483 catalytic site [active] 445932001484 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 445932001485 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 445932001486 purine monophosphate binding site [chemical binding]; other site 445932001487 dimer interface [polypeptide binding]; other site 445932001488 putative catalytic residues [active] 445932001489 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 445932001490 DRTGG domain; Region: DRTGG; pfam07085 445932001491 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 445932001492 SmpB-tmRNA interface; other site 445932001493 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 445932001494 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 445932001495 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 445932001496 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932001497 glutamate dehydrogenase; Provisional; Region: PRK09414 445932001498 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 445932001499 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 445932001500 NAD(P) binding site [chemical binding]; other site 445932001501 glutamate formiminotransferase; Region: FtcD; TIGR02024 445932001502 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 445932001503 Formiminotransferase domain; Region: FTCD; pfam02971 445932001504 peptidase T; Region: peptidase-T; TIGR01882 445932001505 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 445932001506 metal binding site [ion binding]; metal-binding site 445932001507 dimer interface [polypeptide binding]; other site 445932001508 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 445932001509 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 445932001510 putative dimer interface [polypeptide binding]; other site 445932001511 [2Fe-2S] cluster binding site [ion binding]; other site 445932001512 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 445932001513 dimer interface [polypeptide binding]; other site 445932001514 [2Fe-2S] cluster binding site [ion binding]; other site 445932001515 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 445932001516 SLBB domain; Region: SLBB; pfam10531 445932001517 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 445932001518 4Fe-4S binding domain; Region: Fer4; pfam00037 445932001519 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 445932001520 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 445932001521 catalytic loop [active] 445932001522 iron binding site [ion binding]; other site 445932001523 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 445932001524 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 445932001525 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 445932001526 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 445932001527 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 445932001528 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 445932001529 TPR repeat; Region: TPR_11; pfam13414 445932001530 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932001531 binding surface 445932001532 TPR motif; other site 445932001533 Tetratricopeptide repeat; Region: TPR_16; pfam13432 445932001534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932001535 binding surface 445932001536 TPR motif; other site 445932001537 TPR repeat; Region: TPR_11; pfam13414 445932001538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932001539 TPR repeat; Region: TPR_11; pfam13414 445932001540 binding surface 445932001541 TPR motif; other site 445932001542 Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]; Region: IQG1; COG5261 445932001543 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 445932001544 Cell division protein FtsA; Region: FtsA; smart00842 445932001545 Cell division protein FtsA; Region: FtsA; pfam14450 445932001546 cell division protein FtsZ; Validated; Region: PRK09330 445932001547 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 445932001548 nucleotide binding site [chemical binding]; other site 445932001549 SulA interaction site; other site 445932001550 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 445932001551 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 445932001552 Walker A motif; other site 445932001553 ATP binding site [chemical binding]; other site 445932001554 Walker B motif; other site 445932001555 cytidylate kinase; Provisional; Region: cmk; PRK00023 445932001556 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 445932001557 CMP-binding site; other site 445932001558 The sites determining sugar specificity; other site 445932001559 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 445932001560 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 445932001561 putative acyl-acceptor binding pocket; other site 445932001562 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 445932001563 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 445932001564 RNA binding site [nucleotide binding]; other site 445932001565 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 445932001566 RNA binding site [nucleotide binding]; other site 445932001567 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 445932001568 RNA binding site [nucleotide binding]; other site 445932001569 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 445932001570 RNA binding site [nucleotide binding]; other site 445932001571 Methyltransferase domain; Region: Methyltransf_23; pfam13489 445932001572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 445932001573 S-adenosylmethionine binding site [chemical binding]; other site 445932001574 Trp repressor protein; Region: Trp_repressor; cl17266 445932001575 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 445932001576 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 445932001577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 445932001578 catalytic residue [active] 445932001579 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 445932001580 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 445932001581 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 445932001582 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 445932001583 putative active site [active] 445932001584 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 445932001585 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 445932001586 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 445932001587 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 445932001588 trimer interface [polypeptide binding]; other site 445932001589 active site 445932001590 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 445932001591 MgtE intracellular N domain; Region: MgtE_N; cl15244 445932001592 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 445932001593 Divergent AAA domain; Region: AAA_4; pfam04326 445932001594 pyruvate kinase; Provisional; Region: PRK06247 445932001595 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 445932001596 active site 445932001597 domain interfaces; other site 445932001598 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 445932001599 putative acyl-acceptor binding pocket; other site 445932001600 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 445932001601 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 445932001602 Protein export membrane protein; Region: SecD_SecF; pfam02355 445932001603 protein-export membrane protein SecD; Region: secD; TIGR01129 445932001604 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 445932001605 Preprotein translocase subunit; Region: YajC; pfam02699 445932001606 Sulfatase; Region: Sulfatase; cl17466 445932001607 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 445932001608 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 445932001609 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 445932001610 active site 445932001611 dimer interface [polypeptide binding]; other site 445932001612 motif 1; other site 445932001613 motif 2; other site 445932001614 motif 3; other site 445932001615 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 445932001616 anticodon binding site; other site 445932001617 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932001618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 445932001619 non-specific DNA binding site [nucleotide binding]; other site 445932001620 salt bridge; other site 445932001621 sequence-specific DNA binding site [nucleotide binding]; other site 445932001622 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932001623 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 445932001624 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 445932001625 Walker A/P-loop; other site 445932001626 ATP binding site [chemical binding]; other site 445932001627 Q-loop/lid; other site 445932001628 ABC transporter signature motif; other site 445932001629 Walker B; other site 445932001630 D-loop; other site 445932001631 H-loop/switch region; other site 445932001632 ABC transporter; Region: ABC_tran_2; pfam12848 445932001633 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 445932001634 Domain of unknown function (DUF4200); Region: DUF4200; pfam13863 445932001635 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 445932001636 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 445932001637 G1 box; other site 445932001638 putative GEF interaction site [polypeptide binding]; other site 445932001639 GTP/Mg2+ binding site [chemical binding]; other site 445932001640 Switch I region; other site 445932001641 G2 box; other site 445932001642 G3 box; other site 445932001643 Switch II region; other site 445932001644 G4 box; other site 445932001645 G5 box; other site 445932001646 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 445932001647 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 445932001648 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 445932001649 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 445932001650 Secretin and TonB N terminus short domain; Region: STN; smart00965 445932001651 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 445932001652 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 445932001653 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 445932001654 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 445932001655 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 445932001656 Walker A motif; other site 445932001657 ATP binding site [chemical binding]; other site 445932001658 Walker B motif; other site 445932001659 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 445932001660 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 445932001661 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 445932001662 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 445932001663 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 445932001664 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 445932001665 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 445932001666 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 445932001667 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 445932001668 Walker A/P-loop; other site 445932001669 ATP binding site [chemical binding]; other site 445932001670 Q-loop/lid; other site 445932001671 ABC transporter signature motif; other site 445932001672 Walker B; other site 445932001673 D-loop; other site 445932001674 H-loop/switch region; other site 445932001675 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 445932001676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 445932001677 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 445932001678 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 445932001679 putative active site [active] 445932001680 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 445932001681 Sodium Bile acid symporter family; Region: SBF; cl17470 445932001682 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 445932001683 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 445932001684 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 445932001685 ligand binding site [chemical binding]; other site 445932001686 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 445932001687 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 445932001688 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 445932001689 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 445932001690 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 445932001691 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 445932001692 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 445932001693 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 445932001694 trimer interface [polypeptide binding]; other site 445932001695 putative metal binding site [ion binding]; other site 445932001696 Response regulator receiver domain; Region: Response_reg; pfam00072 445932001697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 445932001698 active site 445932001699 phosphorylation site [posttranslational modification] 445932001700 intermolecular recognition site; other site 445932001701 dimerization interface [polypeptide binding]; other site 445932001702 Tetratricopeptide repeat; Region: TPR_12; pfam13424 445932001703 Maf-like protein; Region: Maf; pfam02545 445932001704 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 445932001705 active site 445932001706 dimer interface [polypeptide binding]; other site 445932001707 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 445932001708 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 445932001709 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 445932001710 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 445932001711 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 445932001712 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 445932001713 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932001714 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 445932001715 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 445932001716 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 445932001717 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 445932001718 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 445932001719 NAD binding site [chemical binding]; other site 445932001720 homodimer interface [polypeptide binding]; other site 445932001721 active site 445932001722 substrate binding site [chemical binding]; other site 445932001723 galactokinase; Provisional; Region: PRK05322 445932001724 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 445932001725 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 445932001726 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 445932001727 putative transporter; Provisional; Region: PRK10484 445932001728 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 445932001729 Na binding site [ion binding]; other site 445932001730 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 445932001731 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 445932001732 active site 445932001733 catalytic residues [active] 445932001734 Flavin Reductases; Region: FlaRed; cl00801 445932001735 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 445932001736 Phosphoglycerate kinase; Region: PGK; pfam00162 445932001737 substrate binding site [chemical binding]; other site 445932001738 hinge regions; other site 445932001739 ADP binding site [chemical binding]; other site 445932001740 catalytic site [active] 445932001741 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932001742 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 445932001743 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 445932001744 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 445932001745 Bax inhibitor 1 like; Region: BaxI_1; cl17691 445932001746 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 445932001747 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 445932001748 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 445932001749 putative active site [active] 445932001750 putative metal binding site [ion binding]; other site 445932001751 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 445932001752 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 445932001753 putative active site [active] 445932001754 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 445932001755 Domain of unknown function DUF21; Region: DUF21; pfam01595 445932001756 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 445932001757 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 445932001758 RNA/DNA hybrid binding site [nucleotide binding]; other site 445932001759 active site 445932001760 hypothetical protein; Reviewed; Region: PRK12497 445932001761 purine nucleoside phosphorylase; Provisional; Region: PRK08202 445932001762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932001763 binding surface 445932001764 TPR repeat; Region: TPR_11; pfam13414 445932001765 TPR motif; other site 445932001766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932001767 TPR motif; other site 445932001768 TPR repeat; Region: TPR_11; pfam13414 445932001769 binding surface 445932001770 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 445932001771 dihydropteroate synthase; Region: DHPS; TIGR01496 445932001772 substrate binding pocket [chemical binding]; other site 445932001773 dimer interface [polypeptide binding]; other site 445932001774 inhibitor binding site; inhibition site 445932001775 GTP cyclohydrolase I; Provisional; Region: PLN03044 445932001776 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 445932001777 active site 445932001778 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 445932001779 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 445932001780 FeS/SAM binding site; other site 445932001781 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 445932001782 active site 445932001783 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 445932001784 Bacterial Ig-like domain; Region: Big_5; pfam13205 445932001785 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 445932001786 MG2 domain; Region: A2M_N; pfam01835 445932001787 Alpha-2-macroglobulin family; Region: A2M; pfam00207 445932001788 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 445932001789 surface patch; other site 445932001790 thioester region; other site 445932001791 specificity defining residues; other site 445932001792 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 445932001793 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 445932001794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932001795 putative substrate translocation pore; other site 445932001796 CpXC protein; Region: CpXC; pfam14353 445932001797 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 445932001798 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 445932001799 active site 445932001800 NTP binding site [chemical binding]; other site 445932001801 metal binding triad [ion binding]; metal-binding site 445932001802 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 445932001803 rRNA interaction site [nucleotide binding]; other site 445932001804 S8 interaction site; other site 445932001805 putative laminin-1 binding site; other site 445932001806 elongation factor Ts; Provisional; Region: tsf; PRK09377 445932001807 UBA/TS-N domain; Region: UBA; pfam00627 445932001808 Elongation factor TS; Region: EF_TS; pfam00889 445932001809 Elongation factor TS; Region: EF_TS; pfam00889 445932001810 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932001811 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 445932001812 NAD synthetase; Provisional; Region: PRK13980 445932001813 homodimer interface [polypeptide binding]; other site 445932001814 NAD binding pocket [chemical binding]; other site 445932001815 ATP binding pocket [chemical binding]; other site 445932001816 Mg binding site [ion binding]; other site 445932001817 active-site loop [active] 445932001818 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 445932001819 active site 445932001820 catalytic residues [active] 445932001821 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 445932001822 Sel1-like repeats; Region: SEL1; smart00671 445932001823 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 445932001824 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 445932001825 putative phosphate acyltransferase; Provisional; Region: PRK05331 445932001826 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 445932001827 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 445932001828 NAD(P) binding site [chemical binding]; other site 445932001829 homotetramer interface [polypeptide binding]; other site 445932001830 homodimer interface [polypeptide binding]; other site 445932001831 active site 445932001832 acyl carrier protein; Provisional; Region: acpP; PRK00982 445932001833 ribonuclease III; Reviewed; Region: rnc; PRK00102 445932001834 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 445932001835 dimerization interface [polypeptide binding]; other site 445932001836 active site 445932001837 metal binding site [ion binding]; metal-binding site 445932001838 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 445932001839 dsRNA binding site [nucleotide binding]; other site 445932001840 Ankyrin repeat; Region: Ank; pfam00023 445932001841 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 445932001842 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 445932001843 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 445932001844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932001845 Major Facilitator Superfamily; Region: MFS_1; pfam07690 445932001846 putative substrate translocation pore; other site 445932001847 Major Facilitator Superfamily; Region: MFS_1; pfam07690 445932001848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932001849 Sm and related proteins; Region: Sm_like; cl00259 445932001850 ribosome maturation protein RimP; Reviewed; Region: PRK00092 445932001851 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 445932001852 putative oligomer interface [polypeptide binding]; other site 445932001853 putative RNA binding site [nucleotide binding]; other site 445932001854 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 445932001855 NusA N-terminal domain; Region: NusA_N; pfam08529 445932001856 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 445932001857 RNA binding site [nucleotide binding]; other site 445932001858 homodimer interface [polypeptide binding]; other site 445932001859 NusA-like KH domain; Region: KH_5; pfam13184 445932001860 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 445932001861 G-X-X-G motif; other site 445932001862 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 445932001863 translation initiation factor IF-2; Region: IF-2; TIGR00487 445932001864 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 445932001865 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 445932001866 G1 box; other site 445932001867 putative GEF interaction site [polypeptide binding]; other site 445932001868 GTP/Mg2+ binding site [chemical binding]; other site 445932001869 Switch I region; other site 445932001870 G2 box; other site 445932001871 G3 box; other site 445932001872 Switch II region; other site 445932001873 G4 box; other site 445932001874 G5 box; other site 445932001875 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 445932001876 Translation-initiation factor 2; Region: IF-2; pfam11987 445932001877 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 445932001878 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932001879 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 445932001880 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 445932001881 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 445932001882 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 445932001883 DHH family; Region: DHH; pfam01368 445932001884 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 445932001885 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 445932001886 RNA binding site [nucleotide binding]; other site 445932001887 active site 445932001888 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 445932001889 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 445932001890 active site 445932001891 Riboflavin kinase; Region: Flavokinase; smart00904 445932001892 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 445932001893 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 445932001894 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 445932001895 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 445932001896 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 445932001897 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 445932001898 prolyl-tRNA synthetase; Provisional; Region: PRK09194 445932001899 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 445932001900 dimer interface [polypeptide binding]; other site 445932001901 motif 1; other site 445932001902 active site 445932001903 motif 2; other site 445932001904 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 445932001905 putative deacylase active site [active] 445932001906 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 445932001907 active site 445932001908 motif 3; other site 445932001909 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 445932001910 anticodon binding site; other site 445932001911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 445932001912 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 445932001913 DNA methylase; Region: N6_N4_Mtase; pfam01555 445932001914 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 445932001915 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 445932001916 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 445932001917 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 445932001918 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 445932001919 active site 445932001920 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 445932001921 protein binding site [polypeptide binding]; other site 445932001922 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 445932001923 putative substrate binding region [chemical binding]; other site 445932001924 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 445932001925 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 445932001926 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 445932001927 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 445932001928 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 445932001929 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 445932001930 diaminopimelate decarboxylase; Region: lysA; TIGR01048 445932001931 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 445932001932 active site 445932001933 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 445932001934 substrate binding site [chemical binding]; other site 445932001935 catalytic residues [active] 445932001936 dimer interface [polypeptide binding]; other site 445932001937 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 445932001938 putative FMN binding site [chemical binding]; other site 445932001939 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 445932001940 Phage-related protein [Function unknown]; Region: COG4695 445932001941 Phage portal protein; Region: Phage_portal; pfam04860 445932001942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932001943 TPR motif; other site 445932001944 binding surface 445932001945 TPR repeat; Region: TPR_11; pfam13414 445932001946 TPR repeat; Region: TPR_11; pfam13414 445932001947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932001948 binding surface 445932001949 TPR motif; other site 445932001950 TPR repeat; Region: TPR_11; pfam13414 445932001951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932001952 Tetratricopeptide repeat; Region: TPR_16; pfam13432 445932001953 TPR motif; other site 445932001954 binding surface 445932001955 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 445932001956 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 445932001957 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 445932001958 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 445932001959 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 445932001960 active site 445932001961 dimer interfaces [polypeptide binding]; other site 445932001962 catalytic residues [active] 445932001963 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 445932001964 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 445932001965 catalytic residue [active] 445932001966 putative FPP diphosphate binding site; other site 445932001967 putative FPP binding hydrophobic cleft; other site 445932001968 dimer interface [polypeptide binding]; other site 445932001969 putative IPP diphosphate binding site; other site 445932001970 ribosome recycling factor; Reviewed; Region: frr; PRK00083 445932001971 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 445932001972 hinge region; other site 445932001973 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 445932001974 putative nucleotide binding site [chemical binding]; other site 445932001975 uridine monophosphate binding site [chemical binding]; other site 445932001976 homohexameric interface [polypeptide binding]; other site 445932001977 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 445932001978 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 445932001979 Uncharacterized conserved protein [Function unknown]; Region: COG4198 445932001980 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 445932001981 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 445932001982 putative ligand binding site [chemical binding]; other site 445932001983 putative NAD binding site [chemical binding]; other site 445932001984 putative catalytic site [active] 445932001985 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 445932001986 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 445932001987 catalytic residue [active] 445932001988 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 445932001989 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 445932001990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 445932001991 homodimer interface [polypeptide binding]; other site 445932001992 catalytic residue [active] 445932001993 Trp repressor protein; Region: Trp_repressor; cl17266 445932001994 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 445932001995 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 445932001996 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 445932001997 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 445932001998 histidinol dehydrogenase; Region: hisD; TIGR00069 445932001999 NAD binding site [chemical binding]; other site 445932002000 dimerization interface [polypeptide binding]; other site 445932002001 product binding site; other site 445932002002 substrate binding site [chemical binding]; other site 445932002003 zinc binding site [ion binding]; other site 445932002004 catalytic residues [active] 445932002005 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 445932002006 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 445932002007 active site 445932002008 motif I; other site 445932002009 motif II; other site 445932002010 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 445932002011 putative active site pocket [active] 445932002012 4-fold oligomerization interface [polypeptide binding]; other site 445932002013 metal binding residues [ion binding]; metal-binding site 445932002014 3-fold/trimer interface [polypeptide binding]; other site 445932002015 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 445932002016 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 445932002017 catalytic residues [active] 445932002018 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 445932002019 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 445932002020 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 445932002021 metal binding site [ion binding]; metal-binding site 445932002022 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 445932002023 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 445932002024 RNase_H superfamily; Region: RNase_H_2; pfam13482 445932002025 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 445932002026 propionate/acetate kinase; Provisional; Region: PRK12379 445932002027 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 445932002028 trigger factor; Region: tig; TIGR00115 445932002029 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 445932002030 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 445932002031 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 445932002032 active site 445932002033 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 445932002034 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 445932002035 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 445932002036 dihydroorotase; Validated; Region: pyrC; PRK09357 445932002037 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 445932002038 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 445932002039 active site 445932002040 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 445932002041 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 445932002042 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 445932002043 FAD binding pocket [chemical binding]; other site 445932002044 FAD binding motif [chemical binding]; other site 445932002045 phosphate binding motif [ion binding]; other site 445932002046 beta-alpha-beta structure motif; other site 445932002047 NAD binding pocket [chemical binding]; other site 445932002048 Iron coordination center [ion binding]; other site 445932002049 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 445932002050 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 445932002051 heterodimer interface [polypeptide binding]; other site 445932002052 active site 445932002053 FMN binding site [chemical binding]; other site 445932002054 homodimer interface [polypeptide binding]; other site 445932002055 substrate binding site [chemical binding]; other site 445932002056 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 445932002057 active site 445932002058 dimer interface [polypeptide binding]; other site 445932002059 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 445932002060 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 445932002061 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 445932002062 active site 445932002063 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 445932002064 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 445932002065 active site 445932002066 elongation factor P; Validated; Region: PRK00529 445932002067 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 445932002068 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 445932002069 RNA binding site [nucleotide binding]; other site 445932002070 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 445932002071 RNA binding site [nucleotide binding]; other site 445932002072 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 445932002073 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 445932002074 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 445932002075 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 445932002076 KH domain; Region: KH_4; pfam13083 445932002077 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 445932002078 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 445932002079 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 445932002080 substrate binding site [chemical binding]; other site 445932002081 hexamer interface [polypeptide binding]; other site 445932002082 metal binding site [ion binding]; metal-binding site 445932002083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 445932002084 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 445932002085 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 445932002086 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 445932002087 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 445932002088 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 445932002089 putative active site [active] 445932002090 substrate binding site [chemical binding]; other site 445932002091 putative cosubstrate binding site; other site 445932002092 catalytic site [active] 445932002093 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 445932002094 substrate binding site [chemical binding]; other site 445932002095 SWI complex, BAF60b domains; Region: SWIB; smart00151 445932002096 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 445932002097 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 445932002098 active site 445932002099 substrate-binding site [chemical binding]; other site 445932002100 metal-binding site [ion binding] 445932002101 ATP binding site [chemical binding]; other site 445932002102 aspartate aminotransferase; Provisional; Region: PRK05764 445932002103 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 445932002104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 445932002105 homodimer interface [polypeptide binding]; other site 445932002106 catalytic residue [active] 445932002107 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 445932002108 4Fe-4S binding domain; Region: Fer4; pfam00037 445932002109 4Fe-4S binding domain; Region: Fer4; pfam00037 445932002110 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 445932002111 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 445932002112 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 445932002113 4Fe-4S binding domain; Region: Fer4; pfam00037 445932002114 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 445932002115 Putative Fe-S cluster; Region: FeS; cl17515 445932002116 PAS fold; Region: PAS; pfam00989 445932002117 PAS domain; Region: PAS; smart00091 445932002118 putative active site [active] 445932002119 heme pocket [chemical binding]; other site 445932002120 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 445932002121 dimer interface [polypeptide binding]; other site 445932002122 [2Fe-2S] cluster binding site [ion binding]; other site 445932002123 Phosphotransferase enzyme family; Region: APH; pfam01636 445932002124 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 445932002125 active site 445932002126 ATP binding site [chemical binding]; other site 445932002127 substrate binding site [chemical binding]; other site 445932002128 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 445932002129 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 445932002130 putative catalytic cysteine [active] 445932002131 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 445932002132 putative active site [active] 445932002133 metal binding site [ion binding]; metal-binding site 445932002134 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 445932002135 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 445932002136 CoA binding domain; Region: CoA_binding; pfam02629 445932002137 Transcriptional regulator [Transcription]; Region: LysR; COG0583 445932002138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 445932002139 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 445932002140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 445932002141 S-adenosylmethionine binding site [chemical binding]; other site 445932002142 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 445932002143 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 445932002144 putative active site [active] 445932002145 putative metal binding site [ion binding]; other site 445932002146 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 445932002147 active site 445932002148 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 445932002149 catalytic center binding site [active] 445932002150 ATP binding site [chemical binding]; other site 445932002151 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 445932002152 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 445932002153 ligand binding site [chemical binding]; other site 445932002154 Predicted flavoproteins [General function prediction only]; Region: COG2081 445932002155 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 445932002156 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932002157 Clp protease; Region: CLP_protease; pfam00574 445932002158 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 445932002159 oligomer interface [polypeptide binding]; other site 445932002160 active site residues [active] 445932002161 GMP synthase; Reviewed; Region: guaA; PRK00074 445932002162 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 445932002163 AMP/PPi binding site [chemical binding]; other site 445932002164 candidate oxyanion hole; other site 445932002165 catalytic triad [active] 445932002166 potential glutamine specificity residues [chemical binding]; other site 445932002167 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 445932002168 ATP Binding subdomain [chemical binding]; other site 445932002169 Ligand Binding sites [chemical binding]; other site 445932002170 Dimerization subdomain; other site 445932002171 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 445932002172 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 445932002173 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 445932002174 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 445932002175 active site 445932002176 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 445932002177 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 445932002178 putative catalytic cysteine [active] 445932002179 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 445932002180 putative active site [active] 445932002181 metal binding site [ion binding]; metal-binding site 445932002182 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 445932002183 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 445932002184 ATP binding site [chemical binding]; other site 445932002185 Mg++ binding site [ion binding]; other site 445932002186 motif III; other site 445932002187 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 445932002188 nucleotide binding region [chemical binding]; other site 445932002189 ATP-binding site [chemical binding]; other site 445932002190 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 445932002191 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 445932002192 Serine hydrolase; Region: Ser_hydrolase; cl17834 445932002193 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 445932002194 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932002195 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 445932002196 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 445932002197 active site 445932002198 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 445932002199 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 445932002200 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 445932002201 DNA binding residues [nucleotide binding] 445932002202 MarR family; Region: MarR_2; cl17246 445932002203 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 445932002204 CAAX protease self-immunity; Region: Abi; pfam02517 445932002205 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 445932002206 Major Facilitator Superfamily; Region: MFS_1; pfam07690 445932002207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932002208 putative substrate translocation pore; other site 445932002209 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932002210 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 445932002211 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 445932002212 catalytic residue [active] 445932002213 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 445932002214 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 445932002215 HSP70 interaction site [polypeptide binding]; other site 445932002216 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 445932002217 substrate binding site [polypeptide binding]; other site 445932002218 dimer interface [polypeptide binding]; other site 445932002219 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052 445932002220 Ferritin-like domain; Region: Ferritin; pfam00210 445932002221 diiron binding motif [ion binding]; other site 445932002222 Protein of unknown function (DUF342); Region: DUF342; pfam03961 445932002223 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 445932002224 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 445932002225 motif II; other site 445932002226 GGGtGRT protein; Region: GGGtGRT; pfam14057 445932002227 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 445932002228 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 445932002229 hypothetical protein; Provisional; Region: PRK02947 445932002230 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 445932002231 putative active site [active] 445932002232 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 445932002233 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 445932002234 putative dimer interface [polypeptide binding]; other site 445932002235 putative anticodon binding site; other site 445932002236 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 445932002237 homodimer interface [polypeptide binding]; other site 445932002238 motif 1; other site 445932002239 motif 2; other site 445932002240 active site 445932002241 motif 3; other site 445932002242 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932002243 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 445932002244 tetratricopeptide repeat protein; Provisional; Region: PRK11788 445932002245 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932002246 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 445932002247 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 445932002248 dimer interface [polypeptide binding]; other site 445932002249 PYR/PP interface [polypeptide binding]; other site 445932002250 TPP binding site [chemical binding]; other site 445932002251 substrate binding site [chemical binding]; other site 445932002252 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 445932002253 Domain of unknown function; Region: EKR; pfam10371 445932002254 4Fe-4S binding domain; Region: Fer4; pfam00037 445932002255 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 445932002256 TPP-binding site [chemical binding]; other site 445932002257 dimer interface [polypeptide binding]; other site 445932002258 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932002259 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 445932002260 amphipathic channel; other site 445932002261 Asn-Pro-Ala signature motifs; other site 445932002262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932002263 Major Facilitator Superfamily; Region: MFS_1; pfam07690 445932002264 putative substrate translocation pore; other site 445932002265 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 445932002266 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 445932002267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 445932002268 putative active site [active] 445932002269 heme pocket [chemical binding]; other site 445932002270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 445932002271 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 445932002272 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 445932002273 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 445932002274 putative active site [active] 445932002275 heme pocket [chemical binding]; other site 445932002276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 445932002277 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 445932002278 putative active site [active] 445932002279 heme pocket [chemical binding]; other site 445932002280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 445932002281 putative active site [active] 445932002282 heme pocket [chemical binding]; other site 445932002283 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 445932002284 PAS domain; Region: PAS_9; pfam13426 445932002285 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 445932002286 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 445932002287 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 445932002288 LemA family; Region: LemA; cl00742 445932002289 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 445932002290 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 445932002291 motif II; other site 445932002292 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 445932002293 putative deacylase active site [active] 445932002294 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 445932002295 RDD family; Region: RDD; cl00746 445932002296 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 445932002297 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 445932002298 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 445932002299 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 445932002300 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 445932002301 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 445932002302 DNA topoisomerase; Region: Topoisom_bac; pfam01131 445932002303 DJ-1 family protein; Region: not_thiJ; TIGR01383 445932002304 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 445932002305 conserved cys residue [active] 445932002306 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 445932002307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932002308 putative substrate translocation pore; other site 445932002309 POT family; Region: PTR2; cl17359 445932002310 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 445932002311 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 445932002312 Transglycosylase; Region: Transgly; pfam00912 445932002313 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 445932002314 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 445932002315 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 445932002316 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 445932002317 catalytic site [active] 445932002318 G-X2-G-X-G-K; other site 445932002319 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 445932002320 Fe-S cluster binding site [ion binding]; other site 445932002321 active site 445932002322 primosome assembly protein PriA; Validated; Region: PRK05580 445932002323 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 445932002324 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 445932002325 active site 445932002326 HIGH motif; other site 445932002327 dimer interface [polypeptide binding]; other site 445932002328 KMSKS motif; other site 445932002329 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 445932002330 RNA binding surface [nucleotide binding]; other site 445932002331 YceG-like family; Region: YceG; pfam02618 445932002332 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 445932002333 dimerization interface [polypeptide binding]; other site 445932002334 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 445932002335 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 445932002336 putative active site [active] 445932002337 catalytic site [active] 445932002338 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 445932002339 putative active site [active] 445932002340 catalytic site [active] 445932002341 OsmC-like protein; Region: OsmC; pfam02566 445932002342 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 445932002343 Phage terminase large subunit; Region: Terminase_3; cl12054 445932002344 Terminase-like family; Region: Terminase_6; pfam03237 445932002345 Predicted permeases [General function prediction only]; Region: COG0701 445932002346 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 445932002347 dimerization interface [polypeptide binding]; other site 445932002348 putative DNA binding site [nucleotide binding]; other site 445932002349 putative Zn2+ binding site [ion binding]; other site 445932002350 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 445932002351 CoA binding domain; Region: CoA_binding_2; pfam13380 445932002352 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 445932002353 Uncharacterized conserved protein [Function unknown]; Region: COG3339 445932002354 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 445932002355 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 445932002356 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 445932002357 active site 445932002358 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 445932002359 putative active site [active] 445932002360 putative substrate binding site [chemical binding]; other site 445932002361 ATP binding site [chemical binding]; other site 445932002362 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 445932002363 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 445932002364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 445932002365 catalytic residue [active] 445932002366 homoserine dehydrogenase; Provisional; Region: PRK06349 445932002367 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 445932002368 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 445932002369 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 445932002370 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 445932002371 NAD binding site [chemical binding]; other site 445932002372 substrate binding site [chemical binding]; other site 445932002373 homodimer interface [polypeptide binding]; other site 445932002374 active site 445932002375 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 445932002376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 445932002377 Coenzyme A binding pocket [chemical binding]; other site 445932002378 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 445932002379 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 445932002380 inhibitor-cofactor binding pocket; inhibition site 445932002381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 445932002382 catalytic residue [active] 445932002383 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 445932002384 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 445932002385 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 445932002386 substrate binding site; other site 445932002387 tetramer interface; other site 445932002388 Rhamnan synthesis protein F; Region: RgpF; pfam05045 445932002389 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 445932002390 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 445932002391 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 445932002392 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 445932002393 SseB protein; Region: SseB; cl06279 445932002394 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 445932002395 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 445932002396 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 445932002397 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 445932002398 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 445932002399 flavodoxin; Provisional; Region: PRK05568 445932002400 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 445932002401 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 445932002402 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 445932002403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 445932002404 Walker A/P-loop; other site 445932002405 ATP binding site [chemical binding]; other site 445932002406 Q-loop/lid; other site 445932002407 ABC transporter signature motif; other site 445932002408 Walker B; other site 445932002409 D-loop; other site 445932002410 H-loop/switch region; other site 445932002411 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 445932002412 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 445932002413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 445932002414 Walker A/P-loop; other site 445932002415 ATP binding site [chemical binding]; other site 445932002416 Q-loop/lid; other site 445932002417 ABC transporter signature motif; other site 445932002418 Walker B; other site 445932002419 D-loop; other site 445932002420 H-loop/switch region; other site 445932002421 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 445932002422 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 445932002423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932002424 Major Facilitator Superfamily; Region: MFS_1; pfam07690 445932002425 putative substrate translocation pore; other site 445932002426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932002427 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 445932002428 putative active site [active] 445932002429 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 445932002430 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 445932002431 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 445932002432 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 445932002433 DNA binding residues [nucleotide binding] 445932002434 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 445932002435 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 445932002436 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 445932002437 Walker A/P-loop; other site 445932002438 ATP binding site [chemical binding]; other site 445932002439 Q-loop/lid; other site 445932002440 ABC transporter signature motif; other site 445932002441 Walker B; other site 445932002442 D-loop; other site 445932002443 H-loop/switch region; other site 445932002444 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 445932002445 Peptidase family C4; Region: Peptidase_C4; pfam00863 445932002446 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 445932002447 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 445932002448 Mg++ binding site [ion binding]; other site 445932002449 putative catalytic motif [active] 445932002450 substrate binding site [chemical binding]; other site 445932002451 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 445932002452 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 445932002453 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 445932002454 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 445932002455 active site 445932002456 (T/H)XGH motif; other site 445932002457 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 445932002458 Zn2+ binding site [ion binding]; other site 445932002459 Mg2+ binding site [ion binding]; other site 445932002460 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 445932002461 Oligomerisation domain; Region: Oligomerisation; pfam02410 445932002462 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 445932002463 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 445932002464 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 445932002465 active site 445932002466 HIGH motif; other site 445932002467 KMSK motif region; other site 445932002468 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 445932002469 tRNA binding surface [nucleotide binding]; other site 445932002470 anticodon binding site; other site 445932002471 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 445932002472 MG2 domain; Region: A2M_N; pfam01835 445932002473 Alpha-2-macroglobulin family; Region: A2M; pfam00207 445932002474 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 445932002475 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 445932002476 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 445932002477 putative acyl-acceptor binding pocket; other site 445932002478 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 445932002479 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 445932002480 active site 445932002481 motif I; other site 445932002482 motif II; other site 445932002483 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 445932002484 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 445932002485 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 445932002486 putative ribose interaction site [chemical binding]; other site 445932002487 putative ADP binding site [chemical binding]; other site 445932002488 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 445932002489 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 445932002490 Ligand binding site; other site 445932002491 oligomer interface; other site 445932002492 CTP synthetase; Validated; Region: pyrG; PRK05380 445932002493 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 445932002494 Catalytic site [active] 445932002495 active site 445932002496 UTP binding site [chemical binding]; other site 445932002497 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 445932002498 active site 445932002499 putative oxyanion hole; other site 445932002500 catalytic triad [active] 445932002501 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 445932002502 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 445932002503 DNA binding site [nucleotide binding] 445932002504 active site 445932002505 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 445932002506 active site 445932002507 catalytic residues [active] 445932002508 metal binding site [ion binding]; metal-binding site 445932002509 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 445932002510 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 445932002511 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 445932002512 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 445932002513 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 445932002514 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 445932002515 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 445932002516 ligand binding site [chemical binding]; other site 445932002517 flexible hinge region; other site 445932002518 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 445932002519 putative switch regulator; other site 445932002520 non-specific DNA interactions [nucleotide binding]; other site 445932002521 DNA binding site [nucleotide binding] 445932002522 sequence specific DNA binding site [nucleotide binding]; other site 445932002523 putative cAMP binding site [chemical binding]; other site 445932002524 Ferredoxin [Energy production and conversion]; Region: COG1146 445932002525 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 445932002526 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 445932002527 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 445932002528 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 445932002529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 445932002530 homodimer interface [polypeptide binding]; other site 445932002531 catalytic residue [active] 445932002532 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 445932002533 peptidase T-like protein; Region: PepT-like; TIGR01883 445932002534 metal binding site [ion binding]; metal-binding site 445932002535 putative dimer interface [polypeptide binding]; other site 445932002536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932002537 putative substrate translocation pore; other site 445932002538 POT family; Region: PTR2; cl17359 445932002539 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 445932002540 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 445932002541 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 445932002542 active site turn [active] 445932002543 phosphorylation site [posttranslational modification] 445932002544 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 445932002545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932002546 putative substrate translocation pore; other site 445932002547 POT family; Region: PTR2; cl17359 445932002548 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 445932002549 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 445932002550 ring oligomerisation interface [polypeptide binding]; other site 445932002551 ATP/Mg binding site [chemical binding]; other site 445932002552 stacking interactions; other site 445932002553 hinge regions; other site 445932002554 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 445932002555 oligomerisation interface [polypeptide binding]; other site 445932002556 mobile loop; other site 445932002557 roof hairpin; other site 445932002558 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932002559 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 445932002560 Protein phosphatase 2C; Region: PP2C; pfam00481 445932002561 active site 445932002562 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 445932002563 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 445932002564 active site 445932002565 ATP binding site [chemical binding]; other site 445932002566 substrate binding site [chemical binding]; other site 445932002567 activation loop (A-loop); other site 445932002568 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 445932002569 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 445932002570 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 445932002571 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 445932002572 catalytic residue [active] 445932002573 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 445932002574 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 445932002575 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 445932002576 ligand binding site [chemical binding]; other site 445932002577 Peptidase M15; Region: Peptidase_M15_3; cl01194 445932002578 GRIM-19 protein; Region: GRIM-19; pfam06212 445932002579 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 445932002580 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 445932002581 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 445932002582 Protein of unknown function (DUF1320); Region: DUF1320; cl01818 445932002583 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 445932002584 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 445932002585 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 445932002586 Clp protease; Region: CLP_protease; pfam00574 445932002587 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 445932002588 oligomer interface [polypeptide binding]; other site 445932002589 active site residues [active] 445932002590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 445932002591 Terminase-like family; Region: Terminase_6; pfam03237 445932002592 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 445932002593 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 445932002594 ParB-like nuclease domain; Region: ParBc; pfam02195 445932002595 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 445932002596 DNA methylase; Region: N6_N4_Mtase; pfam01555 445932002597 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 445932002598 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 445932002599 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 445932002600 Methyltransferase domain; Region: Methyltransf_25; pfam13649 445932002601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 445932002602 S-adenosylmethionine binding site [chemical binding]; other site 445932002603 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 445932002604 DNA methylase; Region: N6_N4_Mtase; cl17433 445932002605 DNA methylase; Region: N6_N4_Mtase; pfam01555 445932002606 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 445932002607 restriction alleviation protein, Lar family; Region: anti_R_Lar; TIGR03655 445932002608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 445932002609 VRR-NUC domain; Region: VRR_NUC; cl17748 445932002610 RecT family; Region: RecT; cl04285 445932002611 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 445932002612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 445932002613 AAA domain; Region: AAA_23; pfam13476 445932002614 Walker A/P-loop; other site 445932002615 ATP binding site [chemical binding]; other site 445932002616 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 445932002617 non-specific DNA binding site [nucleotide binding]; other site 445932002618 salt bridge; other site 445932002619 sequence-specific DNA binding site [nucleotide binding]; other site 445932002620 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 445932002621 Catalytic site [active] 445932002622 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 445932002623 active site 445932002624 catalytic residues [active] 445932002625 DNA binding site [nucleotide binding] 445932002626 Int/Topo IB signature motif; other site 445932002627 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 445932002628 H+ Antiporter protein; Region: 2A0121; TIGR00900 445932002629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932002630 Condensation domain; Region: Condensation; pfam00668 445932002631 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 445932002632 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 445932002633 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 445932002634 acyl-activating enzyme (AAE) consensus motif; other site 445932002635 AMP binding site [chemical binding]; other site 445932002636 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 445932002637 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 445932002638 hypothetical protein; Provisional; Region: PRK07206 445932002639 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 445932002640 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 445932002641 Cupin domain; Region: Cupin_2; pfam07883 445932002642 Predicted transcriptional regulators [Transcription]; Region: COG1733 445932002643 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 445932002644 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 445932002645 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 445932002646 META domain; Region: META; pfam03724 445932002647 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 445932002648 ABC1 family; Region: ABC1; cl17513 445932002649 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 445932002650 active site 445932002651 ATP binding site [chemical binding]; other site 445932002652 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 445932002653 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 445932002654 active site 445932002655 ADP/pyrophosphate binding site [chemical binding]; other site 445932002656 dimerization interface [polypeptide binding]; other site 445932002657 allosteric effector site; other site 445932002658 fructose-1,6-bisphosphate binding site; other site 445932002659 TRL-like protein family; Region: TRL; pfam13146 445932002660 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 445932002661 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 445932002662 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 445932002663 catalytic residue [active] 445932002664 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 445932002665 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 445932002666 active site clefts [active] 445932002667 zinc binding site [ion binding]; other site 445932002668 dimer interface [polypeptide binding]; other site 445932002669 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 445932002670 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 445932002671 putative acyl-acceptor binding pocket; other site 445932002672 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 445932002673 acyl-activating enzyme (AAE) consensus motif; other site 445932002674 AMP binding site [chemical binding]; other site 445932002675 active site 445932002676 CoA binding site [chemical binding]; other site 445932002677 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like; cd01619 445932002678 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 445932002679 homodimer interface [polypeptide binding]; other site 445932002680 ligand binding site [chemical binding]; other site 445932002681 NAD binding site [chemical binding]; other site 445932002682 catalytic site [active] 445932002683 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 445932002684 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 445932002685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 445932002686 homodimer interface [polypeptide binding]; other site 445932002687 catalytic residue [active] 445932002688 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 445932002689 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 445932002690 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 445932002691 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 445932002692 catalytic residues [active] 445932002693 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 445932002694 dimer interface [polypeptide binding]; other site 445932002695 FMN binding site [chemical binding]; other site 445932002696 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932002697 thymidine kinase; Provisional; Region: PRK04296 445932002698 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 445932002699 putative Zn2+ binding site [ion binding]; other site 445932002700 putative DNA binding site [nucleotide binding]; other site 445932002701 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 445932002702 Catalytic site [active] 445932002703 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 445932002704 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 445932002705 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 445932002706 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 445932002707 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 445932002708 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 445932002709 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 445932002710 HlyD family secretion protein; Region: HlyD_3; pfam13437 445932002711 Outer membrane efflux protein; Region: OEP; pfam02321 445932002712 Outer membrane efflux protein; Region: OEP; pfam02321 445932002713 MarR family; Region: MarR_2; cl17246 445932002714 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 445932002715 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 445932002716 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 445932002717 active site 445932002718 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 445932002719 Radical SAM superfamily; Region: Radical_SAM; pfam04055 445932002720 FeS/SAM binding site; other site 445932002721 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 445932002722 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 445932002723 active site 445932002724 metal binding site [ion binding]; metal-binding site 445932002725 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 445932002726 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 445932002727 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 445932002728 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 445932002729 catalytic site [active] 445932002730 subunit interface [polypeptide binding]; other site 445932002731 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 445932002732 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 445932002733 ATP-grasp domain; Region: ATP-grasp_4; cl17255 445932002734 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 445932002735 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 445932002736 ATP-grasp domain; Region: ATP-grasp_4; cl17255 445932002737 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 445932002738 substrate binding site [chemical binding]; other site 445932002739 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 445932002740 amidophosphoribosyltransferase; Region: purF; TIGR01134 445932002741 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 445932002742 active site 445932002743 tetramer interface [polypeptide binding]; other site 445932002744 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 445932002745 active site 445932002746 Rubrerythrin [Energy production and conversion]; Region: COG1592 445932002747 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 445932002748 binuclear metal center [ion binding]; other site 445932002749 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 445932002750 iron binding site [ion binding]; other site 445932002751 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 445932002752 metal binding site 2 [ion binding]; metal-binding site 445932002753 putative DNA binding helix; other site 445932002754 metal binding site 1 [ion binding]; metal-binding site 445932002755 structural Zn2+ binding site [ion binding]; other site 445932002756 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 445932002757 active site 445932002758 catalytic site [active] 445932002759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 445932002760 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 445932002761 NAD(P) binding site [chemical binding]; other site 445932002762 active site 445932002763 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 445932002764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 445932002765 Outer membrane efflux protein; Region: OEP; pfam02321 445932002766 Outer membrane efflux protein; Region: OEP; pfam02321 445932002767 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 445932002768 HlyD family secretion protein; Region: HlyD_3; pfam13437 445932002769 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 445932002770 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 445932002771 Walker A/P-loop; other site 445932002772 ATP binding site [chemical binding]; other site 445932002773 Q-loop/lid; other site 445932002774 ABC transporter signature motif; other site 445932002775 Walker B; other site 445932002776 D-loop; other site 445932002777 H-loop/switch region; other site 445932002778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 445932002779 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 445932002780 Walker A/P-loop; other site 445932002781 ATP binding site [chemical binding]; other site 445932002782 Q-loop/lid; other site 445932002783 ABC transporter signature motif; other site 445932002784 Walker B; other site 445932002785 D-loop; other site 445932002786 H-loop/switch region; other site 445932002787 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 445932002788 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 445932002789 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 445932002790 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 445932002791 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 445932002792 CoA binding domain; Region: CoA_binding; cl17356 445932002793 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 445932002794 diiron binding motif [ion binding]; other site 445932002795 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 445932002796 Mechanosensitive ion channel; Region: MS_channel; pfam00924 445932002797 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 445932002798 Hemerythrin; Region: Hemerythrin; cd12107 445932002799 Fe binding site [ion binding]; other site 445932002800 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 445932002801 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 445932002802 Potassium binding sites [ion binding]; other site 445932002803 Cesium cation binding sites [ion binding]; other site 445932002804 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 445932002805 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 445932002806 ATP cone domain; Region: ATP-cone; pfam03477 445932002807 Class III ribonucleotide reductase; Region: RNR_III; cd01675 445932002808 effector binding site; other site 445932002809 active site 445932002810 Zn binding site [ion binding]; other site 445932002811 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 445932002812 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 445932002813 FeS/SAM binding site; other site 445932002814 Predicted transcriptional regulator [Transcription]; Region: COG1959 445932002815 Transcriptional regulator; Region: Rrf2; pfam02082 445932002816 amino acid transporter; Region: 2A0306; TIGR00909 445932002817 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 445932002818 magnesium-transporting ATPase; Provisional; Region: PRK15122 445932002819 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 445932002820 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 445932002821 Soluble P-type ATPase [General function prediction only]; Region: COG4087 445932002822 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 445932002823 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 445932002824 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 445932002825 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 445932002826 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 445932002827 putative active site [active] 445932002828 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 445932002829 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 445932002830 active site turn [active] 445932002831 phosphorylation site [posttranslational modification] 445932002832 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 445932002833 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 445932002834 Sulfatase; Region: Sulfatase; cl17466 445932002835 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 445932002836 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 445932002837 nucleotide binding site [chemical binding]; other site 445932002838 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 445932002839 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 445932002840 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 445932002841 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 445932002842 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 445932002843 FeoA domain; Region: FeoA; pfam04023 445932002844 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 445932002845 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 445932002846 G1 box; other site 445932002847 GTP/Mg2+ binding site [chemical binding]; other site 445932002848 G2 box; other site 445932002849 Switch I region; other site 445932002850 G3 box; other site 445932002851 Switch II region; other site 445932002852 G4 box; other site 445932002853 G5 box; other site 445932002854 Nucleoside recognition; Region: Gate; pfam07670 445932002855 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 445932002856 Nucleoside recognition; Region: Gate; pfam07670 445932002857 Peptidase M15; Region: Peptidase_M15_3; cl01194 445932002858 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 445932002859 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 445932002860 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 445932002861 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 445932002862 Phage capsid family; Region: Phage_capsid; pfam05065 445932002863 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 445932002864 O-Antigen ligase; Region: Wzy_C; pfam04932 445932002865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 445932002866 TPR motif; other site 445932002867 binding surface 445932002868 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 445932002869 O-Antigen ligase; Region: Wzy_C; cl04850 445932002870 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 445932002871 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 445932002872 ATP-grasp domain; Region: ATP-grasp_4; cl17255 445932002873 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 445932002874 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 445932002875 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 445932002876 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 445932002877 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 445932002878 hinge; other site 445932002879 active site 445932002880 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 445932002881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 445932002882 S-adenosylmethionine binding site [chemical binding]; other site 445932002883 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932002884 peptide chain release factor 1; Validated; Region: prfA; PRK00591 445932002885 PCRF domain; Region: PCRF; pfam03462 445932002886 RF-1 domain; Region: RF-1; pfam00472 445932002887 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 445932002888 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 445932002889 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 445932002890 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 445932002891 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 445932002892 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 445932002893 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 445932002894 active site 445932002895 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 445932002896 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 445932002897 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 445932002898 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 445932002899 active site 445932002900 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 445932002901 putative NADP binding site [chemical binding]; other site 445932002902 active site 445932002903 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 445932002904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932002905 binding surface 445932002906 TPR motif; other site 445932002907 Mitochondria Fission Protein Fis1, cytosolic domain; Region: Fis1; cd12212 445932002908 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 445932002909 active site 445932002910 phosphorylation site [posttranslational modification] 445932002911 Amino acid permease; Region: AA_permease_2; pfam13520 445932002912 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 445932002913 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 445932002914 ACT domain-containing protein [General function prediction only]; Region: COG4747 445932002915 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 445932002916 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 445932002917 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932002918 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 445932002919 IHF - DNA interface [nucleotide binding]; other site 445932002920 IHF dimer interface [polypeptide binding]; other site 445932002921 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 445932002922 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 445932002923 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 445932002924 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 445932002925 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 445932002926 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 445932002927 HflX GTPase family; Region: HflX; cd01878 445932002928 G1 box; other site 445932002929 GTP/Mg2+ binding site [chemical binding]; other site 445932002930 Switch I region; other site 445932002931 G2 box; other site 445932002932 G3 box; other site 445932002933 Switch II region; other site 445932002934 G4 box; other site 445932002935 G5 box; other site 445932002936 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 445932002937 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 445932002938 PilZ domain; Region: PilZ; pfam07238 445932002939 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 445932002940 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 445932002941 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 445932002942 FeS/SAM binding site; other site 445932002943 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 445932002944 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 445932002945 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 445932002946 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 445932002947 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 445932002948 dimer interface [polypeptide binding]; other site 445932002949 active site 445932002950 TPR repeat; Region: TPR_11; pfam13414 445932002951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932002952 binding surface 445932002953 TPR motif; other site 445932002954 Bacterial SH3 domain; Region: SH3_3; cl17532 445932002955 Oxygen tolerance; Region: BatD; pfam13584 445932002956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932002957 binding surface 445932002958 TPR motif; other site 445932002959 hypothetical protein; Provisional; Region: PRK13685 445932002960 von Willebrand factor type A domain; Region: VWA_2; pfam13519 445932002961 metal ion-dependent adhesion site (MIDAS); other site 445932002962 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 445932002963 metal ion-dependent adhesion site (MIDAS); other site 445932002964 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 445932002965 Protein of unknown function DUF58; Region: DUF58; pfam01882 445932002966 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 445932002967 MoxR-like ATPases [General function prediction only]; Region: COG0714 445932002968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445932002969 Walker A motif; other site 445932002970 ATP binding site [chemical binding]; other site 445932002971 Walker B motif; other site 445932002972 arginine finger; other site 445932002973 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 445932002974 nickel binding site [ion binding]; other site 445932002975 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 445932002976 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 445932002977 NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; Region: NuoH; COG1005 445932002978 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 445932002979 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 445932002980 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 445932002981 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 445932002982 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 445932002983 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 445932002984 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 445932002985 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 445932002986 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009 445932002987 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 445932002988 hydrogenase 4 subunit D; Validated; Region: PRK06525 445932002989 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 445932002990 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 445932002991 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 445932002992 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 445932002993 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 445932002994 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932002995 binding surface 445932002996 TPR motif; other site 445932002997 TPR repeat; Region: TPR_11; pfam13414 445932002998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932002999 binding surface 445932003000 TPR motif; other site 445932003001 TPR repeat; Region: TPR_11; pfam13414 445932003002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932003003 binding surface 445932003004 TPR motif; other site 445932003005 TPR repeat; Region: TPR_11; pfam13414 445932003006 lipoprotein signal peptidase; Provisional; Region: PRK14787 445932003007 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 445932003008 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 445932003009 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 445932003010 active site 445932003011 HIGH motif; other site 445932003012 nucleotide binding site [chemical binding]; other site 445932003013 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 445932003014 active site 445932003015 KMSKS motif; other site 445932003016 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 445932003017 tRNA binding surface [nucleotide binding]; other site 445932003018 anticodon binding site; other site 445932003019 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 445932003020 Predicted membrane protein [Function unknown]; Region: COG1288 445932003021 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 445932003022 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 445932003023 Na binding site [ion binding]; other site 445932003024 Thiamine pyrophosphokinase; Region: TPK; cd07995 445932003025 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 445932003026 active site 445932003027 dimerization interface [polypeptide binding]; other site 445932003028 thiamine binding site [chemical binding]; other site 445932003029 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 445932003030 hypothetical protein; Validated; Region: PRK00110 445932003031 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 445932003032 active site 445932003033 putative DNA-binding cleft [nucleotide binding]; other site 445932003034 dimer interface [polypeptide binding]; other site 445932003035 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 445932003036 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 445932003037 active site 1 [active] 445932003038 active site 2 [active] 445932003039 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 445932003040 active site 2 [active] 445932003041 active site 1 [active] 445932003042 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932003043 binding surface 445932003044 TPR motif; other site 445932003045 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932003046 binding surface 445932003047 TPR motif; other site 445932003048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 445932003049 binding surface 445932003050 TPR motif; other site 445932003051 Tetratricopeptide repeat; Region: TPR_12; pfam13424 445932003052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932003053 binding surface 445932003054 TPR motif; other site 445932003055 Tetratricopeptide repeat; Region: TPR_16; pfam13432 445932003056 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 445932003057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 445932003058 Coenzyme A binding pocket [chemical binding]; other site 445932003059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 445932003060 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 445932003061 Glycoprotease family; Region: Peptidase_M22; pfam00814 445932003062 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 445932003063 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 445932003064 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 445932003065 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 445932003066 FeS/SAM binding site; other site 445932003067 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 445932003068 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 445932003069 Cl- selectivity filter; other site 445932003070 Cl- binding residues [ion binding]; other site 445932003071 pore gating glutamate residue; other site 445932003072 dimer interface [polypeptide binding]; other site 445932003073 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932003074 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 445932003075 adenosine deaminase; Provisional; Region: PRK09358 445932003076 active site 445932003077 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 445932003078 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 445932003079 active site 445932003080 HIGH motif; other site 445932003081 nucleotide binding site [chemical binding]; other site 445932003082 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 445932003083 KMSKS motif; other site 445932003084 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 445932003085 tRNA binding surface [nucleotide binding]; other site 445932003086 anticodon binding site; other site 445932003087 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 445932003088 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 445932003089 substrate binding site; other site 445932003090 dimer interface; other site 445932003091 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 445932003092 homotrimer interaction site [polypeptide binding]; other site 445932003093 zinc binding site [ion binding]; other site 445932003094 CDP-binding sites; other site 445932003095 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 445932003096 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 445932003097 RNase E interface [polypeptide binding]; other site 445932003098 trimer interface [polypeptide binding]; other site 445932003099 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 445932003100 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 445932003101 RNase E interface [polypeptide binding]; other site 445932003102 trimer interface [polypeptide binding]; other site 445932003103 active site 445932003104 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 445932003105 putative nucleic acid binding region [nucleotide binding]; other site 445932003106 G-X-X-G motif; other site 445932003107 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 445932003108 RNA binding site [nucleotide binding]; other site 445932003109 domain interface; other site 445932003110 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 445932003111 16S/18S rRNA binding site [nucleotide binding]; other site 445932003112 S13e-L30e interaction site [polypeptide binding]; other site 445932003113 25S rRNA binding site [nucleotide binding]; other site 445932003114 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 445932003115 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 445932003116 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 445932003117 Ligand Binding Site [chemical binding]; other site 445932003118 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 445932003119 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 445932003120 FeS/SAM binding site; other site 445932003121 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 445932003122 RNA/DNA hybrid binding site [nucleotide binding]; other site 445932003123 active site 445932003124 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 445932003125 catalytic motif [active] 445932003126 Zn binding site [ion binding]; other site 445932003127 inner membrane protein; Provisional; Region: PRK11715 445932003128 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 445932003129 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 445932003130 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 445932003131 HlyD family secretion protein; Region: HlyD_3; pfam13437 445932003132 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 445932003133 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 445932003134 Walker A/P-loop; other site 445932003135 ATP binding site [chemical binding]; other site 445932003136 Q-loop/lid; other site 445932003137 ABC transporter signature motif; other site 445932003138 Walker B; other site 445932003139 D-loop; other site 445932003140 H-loop/switch region; other site 445932003141 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 445932003142 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 445932003143 FtsX-like permease family; Region: FtsX; pfam02687 445932003144 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 445932003145 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 445932003146 carboxyltransferase (CT) interaction site; other site 445932003147 biotinylation site [posttranslational modification]; other site 445932003148 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 445932003149 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 445932003150 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 445932003151 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 445932003152 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 445932003153 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 445932003154 active site 445932003155 HIGH motif; other site 445932003156 nucleotide binding site [chemical binding]; other site 445932003157 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 445932003158 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 445932003159 substrate-cofactor binding pocket; other site 445932003160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 445932003161 catalytic residue [active] 445932003162 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 445932003163 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 445932003164 FeS/SAM binding site; other site 445932003165 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 445932003166 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 445932003167 ATP cone domain; Region: ATP-cone; pfam03477 445932003168 Class III ribonucleotide reductase; Region: RNR_III; cd01675 445932003169 effector binding site; other site 445932003170 active site 445932003171 Zn binding site [ion binding]; other site 445932003172 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 445932003173 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 445932003174 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 445932003175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 445932003176 active site 445932003177 phosphorylation site [posttranslational modification] 445932003178 intermolecular recognition site; other site 445932003179 dimerization interface [polypeptide binding]; other site 445932003180 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 445932003181 DNA binding residues [nucleotide binding] 445932003182 dimerization interface [polypeptide binding]; other site 445932003183 Response regulator receiver domain; Region: Response_reg; pfam00072 445932003184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 445932003185 active site 445932003186 phosphorylation site [posttranslational modification] 445932003187 intermolecular recognition site; other site 445932003188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 445932003189 dimerization interface [polypeptide binding]; other site 445932003190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 445932003191 dimer interface [polypeptide binding]; other site 445932003192 phosphorylation site [posttranslational modification] 445932003193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 445932003194 ATP binding site [chemical binding]; other site 445932003195 Mg2+ binding site [ion binding]; other site 445932003196 G-X-G motif; other site 445932003197 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 445932003198 dimerization interface [polypeptide binding]; other site 445932003199 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 445932003200 dimer interface [polypeptide binding]; other site 445932003201 phosphorylation site [posttranslational modification] 445932003202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 445932003203 ATP binding site [chemical binding]; other site 445932003204 Mg2+ binding site [ion binding]; other site 445932003205 G-X-G motif; other site 445932003206 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 445932003207 dimerization interface [polypeptide binding]; other site 445932003208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932003209 TPR motif; other site 445932003210 binding surface 445932003211 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 445932003212 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 445932003213 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 445932003214 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 445932003215 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 445932003216 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 445932003217 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 445932003218 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 445932003219 ATP binding site [chemical binding]; other site 445932003220 Walker A motif; other site 445932003221 hexamer interface [polypeptide binding]; other site 445932003222 Walker B motif; other site 445932003223 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 445932003224 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 445932003225 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 445932003226 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 445932003227 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 445932003228 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 445932003229 metal binding site [ion binding]; metal-binding site 445932003230 active site 445932003231 I-site; other site 445932003232 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 445932003233 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 445932003234 UGMP family protein; Validated; Region: PRK09604 445932003235 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 445932003236 C-terminal peptidase (prc); Region: prc; TIGR00225 445932003237 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 445932003238 protein binding site [polypeptide binding]; other site 445932003239 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 445932003240 Catalytic dyad [active] 445932003241 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 445932003242 Peptidase family M23; Region: Peptidase_M23; pfam01551 445932003243 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 445932003244 dimer interface [polypeptide binding]; other site 445932003245 Alkaline phosphatase homologues; Region: alkPPc; smart00098 445932003246 active site 445932003247 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 445932003248 glycogen synthase; Provisional; Region: glgA; PRK00654 445932003249 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 445932003250 ADP-binding pocket [chemical binding]; other site 445932003251 homodimer interface [polypeptide binding]; other site 445932003252 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 445932003253 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 445932003254 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 445932003255 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 445932003256 active site 445932003257 HIGH motif; other site 445932003258 dimer interface [polypeptide binding]; other site 445932003259 KMSKS motif; other site 445932003260 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 445932003261 Peptidase family M50; Region: Peptidase_M50; pfam02163 445932003262 active site 445932003263 putative substrate binding region [chemical binding]; other site 445932003264 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 445932003265 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 445932003266 nucleotide binding pocket [chemical binding]; other site 445932003267 K-X-D-G motif; other site 445932003268 catalytic site [active] 445932003269 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 445932003270 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 445932003271 BRCA1 C Terminus (BRCT) domain; Region: BRCT; pfam00533 445932003272 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 445932003273 putative RNA binding site [nucleotide binding]; other site 445932003274 threonine synthase; Validated; Region: PRK06260 445932003275 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 445932003276 homodimer interface [polypeptide binding]; other site 445932003277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 445932003278 catalytic residue [active] 445932003279 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 445932003280 hypothetical protein; Provisional; Region: PRK09133 445932003281 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 445932003282 metal binding site [ion binding]; metal-binding site 445932003283 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 445932003284 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 445932003285 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 445932003286 Walker A/P-loop; other site 445932003287 ATP binding site [chemical binding]; other site 445932003288 Q-loop/lid; other site 445932003289 ABC transporter signature motif; other site 445932003290 Walker B; other site 445932003291 D-loop; other site 445932003292 H-loop/switch region; other site 445932003293 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 445932003294 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 445932003295 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 445932003296 Walker A/P-loop; other site 445932003297 ATP binding site [chemical binding]; other site 445932003298 Q-loop/lid; other site 445932003299 ABC transporter signature motif; other site 445932003300 Walker B; other site 445932003301 D-loop; other site 445932003302 H-loop/switch region; other site 445932003303 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 445932003304 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 445932003305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 445932003306 dimer interface [polypeptide binding]; other site 445932003307 conserved gate region; other site 445932003308 putative PBP binding loops; other site 445932003309 ABC-ATPase subunit interface; other site 445932003310 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 445932003311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 445932003312 dimer interface [polypeptide binding]; other site 445932003313 conserved gate region; other site 445932003314 ABC-ATPase subunit interface; other site 445932003315 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 445932003316 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 445932003317 acyl-activating enzyme (AAE) consensus motif; other site 445932003318 AMP binding site [chemical binding]; other site 445932003319 active site 445932003320 CoA binding site [chemical binding]; other site 445932003321 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 445932003322 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 445932003323 metal binding triad [ion binding]; metal-binding site 445932003324 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 445932003325 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 445932003326 Zn2+ binding site [ion binding]; other site 445932003327 Mg2+ binding site [ion binding]; other site 445932003328 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 445932003329 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 445932003330 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 445932003331 S-adenosylmethionine synthetase; Validated; Region: PRK05250 445932003332 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 445932003333 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 445932003334 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 445932003335 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 445932003336 active site 445932003337 putative catalytic site [active] 445932003338 phosphate binding site A [ion binding]; other site 445932003339 DNA binding site [nucleotide binding] 445932003340 metal binding site A [ion binding]; metal-binding site 445932003341 putative AP binding site [nucleotide binding]; other site 445932003342 putative metal binding site B [ion binding]; other site 445932003343 phosphate binding site B [ion binding]; other site 445932003344 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 445932003345 putative metal binding site; other site 445932003346 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 445932003347 putative active site [active] 445932003348 putative metal binding site [ion binding]; other site 445932003349 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 445932003350 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 445932003351 active site 445932003352 homodimer interface [polypeptide binding]; other site 445932003353 cell division protein FtsW; Region: ftsW; TIGR02614 445932003354 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 445932003355 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 445932003356 Mg++ binding site [ion binding]; other site 445932003357 putative catalytic motif [active] 445932003358 putative substrate binding site [chemical binding]; other site 445932003359 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 445932003360 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 445932003361 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 445932003362 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 445932003363 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 445932003364 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 445932003365 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 445932003366 Cell division protein FtsL; Region: FtsL; cl11433 445932003367 MraW methylase family; Region: Methyltransf_5; cl17771 445932003368 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 445932003369 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 445932003370 Zn binding site [ion binding]; other site 445932003371 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 445932003372 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 445932003373 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 445932003374 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 445932003375 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 445932003376 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 445932003377 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 445932003378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 445932003379 trmE is a tRNA modification GTPase; Region: trmE; cd04164 445932003380 G1 box; other site 445932003381 Walker A/P-loop; other site 445932003382 GTP/Mg2+ binding site [chemical binding]; other site 445932003383 ATP binding site [chemical binding]; other site 445932003384 Switch I region; other site 445932003385 G2 box; other site 445932003386 Switch II region; other site 445932003387 G3 box; other site 445932003388 G4 box; other site 445932003389 G5 box; other site 445932003390 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 445932003391 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 445932003392 G-X-X-G motif; other site 445932003393 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 445932003394 RxxxH motif; other site 445932003395 membrane protein insertase; Provisional; Region: PRK01318 445932003396 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 445932003397 Haemolytic domain; Region: Haemolytic; pfam01809 445932003398 Ribonuclease P; Region: Ribonuclease_P; pfam00825 445932003399 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 445932003400 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 445932003401 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 445932003402 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 445932003403 active site 445932003404 Zn binding site [ion binding]; other site 445932003405 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 445932003406 phosphoglucomutase; Validated; Region: PRK07564 445932003407 active site 445932003408 substrate binding site [chemical binding]; other site 445932003409 metal binding site [ion binding]; metal-binding site 445932003410 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 445932003411 FAD binding domain; Region: FAD_binding_4; pfam01565 445932003412 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 445932003413 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK03824 445932003414 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 445932003415 AAA domain; Region: AAA_31; pfam13614 445932003416 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 445932003417 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 445932003418 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 445932003419 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 445932003420 GatB domain; Region: GatB_Yqey; smart00845 445932003421 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 445932003422 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 445932003423 ligand binding site [chemical binding]; other site 445932003424 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 445932003425 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 445932003426 TolB amino-terminal domain; Region: TolB_N; pfam04052 445932003427 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 445932003428 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 445932003429 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 445932003430 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 445932003431 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 445932003432 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 445932003433 catalytic residues [active] 445932003434 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 445932003435 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 445932003436 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 445932003437 active site 445932003438 catalytic tetrad [active] 445932003439 CoA binding domain; Region: CoA_binding_2; pfam13380 445932003440 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 445932003441 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 445932003442 Part of AAA domain; Region: AAA_19; pfam13245 445932003443 Family description; Region: UvrD_C_2; pfam13538 445932003444 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 445932003445 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 445932003446 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 445932003447 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 445932003448 catalytic core [active] 445932003449 Bacitracin resistance protein BacA; Region: BacA; pfam02673 445932003450 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 445932003451 putative active site [active] 445932003452 catalytic residue [active] 445932003453 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 445932003454 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 445932003455 5S rRNA interface [nucleotide binding]; other site 445932003456 CTC domain interface [polypeptide binding]; other site 445932003457 L16 interface [polypeptide binding]; other site 445932003458 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 445932003459 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 445932003460 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 445932003461 active site 445932003462 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 445932003463 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 445932003464 Substrate binding site; other site 445932003465 Mg++ binding site; other site 445932003466 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 445932003467 active site 445932003468 substrate binding site [chemical binding]; other site 445932003469 CoA binding site [chemical binding]; other site 445932003470 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 445932003471 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 445932003472 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 445932003473 FeS/SAM binding site; other site 445932003474 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 445932003475 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 445932003476 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 445932003477 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 445932003478 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 445932003479 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 445932003480 HSP70 interaction site [polypeptide binding]; other site 445932003481 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 445932003482 Zn binding sites [ion binding]; other site 445932003483 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 445932003484 dimer interface [polypeptide binding]; other site 445932003485 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 445932003486 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 445932003487 inhibitor-cofactor binding pocket; inhibition site 445932003488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 445932003489 catalytic residue [active] 445932003490 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 445932003491 MgtC family; Region: MgtC; pfam02308 445932003492 Predicted cation transporter [General function prediction only]; Region: COG4756 445932003493 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 445932003494 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 445932003495 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 445932003496 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 445932003497 active site 445932003498 dimerization interface [polypeptide binding]; other site 445932003499 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 445932003500 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 445932003501 putative ADP-binding pocket [chemical binding]; other site 445932003502 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 445932003503 active site 445932003504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932003505 binding surface 445932003506 TPR motif; other site 445932003507 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 445932003508 Catalytic domain of Protein Kinases; Region: PKc; cd00180 445932003509 active site 445932003510 ATP binding site [chemical binding]; other site 445932003511 substrate binding site [chemical binding]; other site 445932003512 activation loop (A-loop); other site 445932003513 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 445932003514 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 445932003515 FtsX-like permease family; Region: FtsX; pfam02687 445932003516 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 445932003517 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 445932003518 Walker A/P-loop; other site 445932003519 ATP binding site [chemical binding]; other site 445932003520 Q-loop/lid; other site 445932003521 ABC transporter signature motif; other site 445932003522 Walker B; other site 445932003523 D-loop; other site 445932003524 H-loop/switch region; other site 445932003525 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 445932003526 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 445932003527 SAF domain; Region: SAF; pfam08666 445932003528 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 445932003529 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 445932003530 putative substrate binding site [chemical binding]; other site 445932003531 putative ATP binding site [chemical binding]; other site 445932003532 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 445932003533 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 445932003534 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 445932003535 glutaminase active site [active] 445932003536 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 445932003537 dimer interface [polypeptide binding]; other site 445932003538 active site 445932003539 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 445932003540 dimer interface [polypeptide binding]; other site 445932003541 active site 445932003542 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 445932003543 active site 445932003544 hydrophilic channel; other site 445932003545 dimerization interface [polypeptide binding]; other site 445932003546 catalytic residues [active] 445932003547 active site lid [active] 445932003548 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 445932003549 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 445932003550 active site 445932003551 substrate binding site [chemical binding]; other site 445932003552 metal binding site [ion binding]; metal-binding site 445932003553 FtsH Extracellular; Region: FtsH_ext; pfam06480 445932003554 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 445932003555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445932003556 ATP binding site [chemical binding]; other site 445932003557 Walker A motif; other site 445932003558 Walker B motif; other site 445932003559 arginine finger; other site 445932003560 Peptidase family M41; Region: Peptidase_M41; pfam01434 445932003561 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 445932003562 active site 445932003563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 445932003564 binding surface 445932003565 TPR motif; other site 445932003566 Tetratricopeptide repeat; Region: TPR_16; pfam13432 445932003567 Protein of unknown function (DUF560); Region: DUF560; pfam04575 445932003568 Predicted membrane protein [Function unknown]; Region: COG1971 445932003569 Domain of unknown function DUF; Region: DUF204; pfam02659 445932003570 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 445932003571 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 445932003572 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 445932003573 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 445932003574 putative FMN binding site [chemical binding]; other site 445932003575 biotin synthase; Provisional; Region: PRK07094 445932003576 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 445932003577 FeS/SAM binding site; other site 445932003578 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 445932003579 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 445932003580 Mechanosensitive ion channel; Region: MS_channel; pfam00924 445932003581 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 445932003582 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 445932003583 FeS/SAM binding site; other site 445932003584 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 445932003585 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 445932003586 CoenzymeA binding site [chemical binding]; other site 445932003587 subunit interaction site [polypeptide binding]; other site 445932003588 PHB binding site; other site 445932003589 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 445932003590 putative active site; other site 445932003591 putative metal binding residues [ion binding]; other site 445932003592 signature motif; other site 445932003593 putative triphosphate binding site [ion binding]; other site 445932003594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 445932003595 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 445932003596 dimerization interface [polypeptide binding]; other site 445932003597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 445932003598 dimer interface [polypeptide binding]; other site 445932003599 phosphorylation site [posttranslational modification] 445932003600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 445932003601 ATP binding site [chemical binding]; other site 445932003602 Mg2+ binding site [ion binding]; other site 445932003603 G-X-G motif; other site 445932003604 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 445932003605 active site 445932003606 catalytic site [active] 445932003607 substrate binding site [chemical binding]; other site 445932003608 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 445932003609 phosphoglyceromutase; Provisional; Region: PRK05434 445932003610 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 445932003611 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 445932003612 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 445932003613 putative RNA binding site [nucleotide binding]; other site 445932003614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 445932003615 S-adenosylmethionine binding site [chemical binding]; other site 445932003616 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 445932003617 active site 445932003618 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 445932003619 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 445932003620 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 445932003621 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 445932003622 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 445932003623 active site 445932003624 dimer interface [polypeptide binding]; other site 445932003625 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 445932003626 active site 445932003627 trimer interface [polypeptide binding]; other site 445932003628 allosteric site; other site 445932003629 active site lid [active] 445932003630 hexamer (dimer of trimers) interface [polypeptide binding]; other site 445932003631 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 445932003632 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 445932003633 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 445932003634 active site turn [active] 445932003635 phosphorylation site [posttranslational modification] 445932003636 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 445932003637 HPr interaction site; other site 445932003638 glycerol kinase (GK) interaction site [polypeptide binding]; other site 445932003639 active site 445932003640 phosphorylation site [posttranslational modification] 445932003641 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 445932003642 dimerization domain swap beta strand [polypeptide binding]; other site 445932003643 regulatory protein interface [polypeptide binding]; other site 445932003644 active site 445932003645 regulatory phosphorylation site [posttranslational modification]; other site 445932003646 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 445932003647 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 445932003648 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 445932003649 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 445932003650 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 445932003651 tetramer interface [polypeptide binding]; other site 445932003652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 445932003653 catalytic residue [active] 445932003654 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 445932003655 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 445932003656 tetramer interface [polypeptide binding]; other site 445932003657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 445932003658 catalytic residue [active] 445932003659 glycine cleavage system protein H; Provisional; Region: PRK13380 445932003660 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 445932003661 lipoyl attachment site [posttranslational modification]; other site 445932003662 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 445932003663 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 445932003664 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 445932003665 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 445932003666 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 445932003667 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 445932003668 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 445932003669 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 445932003670 dimer interface [polypeptide binding]; other site 445932003671 ssDNA binding site [nucleotide binding]; other site 445932003672 tetramer (dimer of dimers) interface [polypeptide binding]; other site 445932003673 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 445932003674 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 445932003675 adenylosuccinate synthase; Region: purA; TIGR00184 445932003676 adenylosuccinate lyase; Provisional; Region: PRK09285 445932003677 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 445932003678 tetramer interface [polypeptide binding]; other site 445932003679 hypothetical protein; Reviewed; Region: PRK00024 445932003680 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 445932003681 MPN+ (JAMM) motif; other site 445932003682 Zinc-binding site [ion binding]; other site 445932003683 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 445932003684 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 445932003685 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 445932003686 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 445932003687 butyrate kinase; Provisional; Region: PRK03011 445932003688 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 445932003689 putative peptidase; Provisional; Region: PRK11649 445932003690 Peptidase family M23; Region: Peptidase_M23; pfam01551 445932003691 AAA domain; Region: AAA_28; pfam13521 445932003692 Predicted ATPase [General function prediction only]; Region: COG3911 445932003693 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932003694 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 445932003695 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 445932003696 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 445932003697 active site 445932003698 metal binding site [ion binding]; metal-binding site 445932003699 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 445932003700 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 445932003701 homodimer interface [polypeptide binding]; other site 445932003702 oligonucleotide binding site [chemical binding]; other site 445932003703 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 445932003704 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 445932003705 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 445932003706 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 445932003707 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 445932003708 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 445932003709 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 445932003710 rod shape-determining protein MreC; Provisional; Region: PRK13922 445932003711 rod shape-determining protein MreC; Region: MreC; pfam04085 445932003712 gamma-glutamyl kinase; Provisional; Region: PRK05429 445932003713 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 445932003714 nucleotide binding site [chemical binding]; other site 445932003715 homotetrameric interface [polypeptide binding]; other site 445932003716 putative phosphate binding site [ion binding]; other site 445932003717 putative allosteric binding site; other site 445932003718 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 445932003719 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 445932003720 putative catalytic cysteine [active] 445932003721 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 445932003722 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 445932003723 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 445932003724 methionine sulfoxide reductase B; Provisional; Region: PRK00222 445932003725 SelR domain; Region: SelR; pfam01641 445932003726 TraB family; Region: TraB; cl12050 445932003727 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932003728 rod shape-determining protein MreB; Provisional; Region: PRK13927 445932003729 MreB and similar proteins; Region: MreB_like; cd10225 445932003730 nucleotide binding site [chemical binding]; other site 445932003731 Mg binding site [ion binding]; other site 445932003732 putative protofilament interaction site [polypeptide binding]; other site 445932003733 RodZ interaction site [polypeptide binding]; other site 445932003734 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 445932003735 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 445932003736 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 445932003737 alphaNTD homodimer interface [polypeptide binding]; other site 445932003738 alphaNTD - beta interaction site [polypeptide binding]; other site 445932003739 alphaNTD - beta' interaction site [polypeptide binding]; other site 445932003740 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 445932003741 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 445932003742 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 445932003743 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 445932003744 RNA binding surface [nucleotide binding]; other site 445932003745 30S ribosomal protein S11; Validated; Region: PRK05309 445932003746 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 445932003747 30S ribosomal protein S13; Region: bact_S13; TIGR03631 445932003748 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 445932003749 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 445932003750 rRNA binding site [nucleotide binding]; other site 445932003751 predicted 30S ribosome binding site; other site 445932003752 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 445932003753 active site 445932003754 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 445932003755 adenylate kinase; Reviewed; Region: adk; PRK00279 445932003756 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 445932003757 AMP-binding site [chemical binding]; other site 445932003758 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 445932003759 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 445932003760 SecY translocase; Region: SecY; pfam00344 445932003761 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 445932003762 Ribosomal protein S5 [Translation, ribosomal structure and biogenesis]; Region: RpsE; COG0098 445932003763 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 445932003764 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 445932003765 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 445932003766 23S rRNA interface [nucleotide binding]; other site 445932003767 L21e interface [polypeptide binding]; other site 445932003768 5S rRNA interface [nucleotide binding]; other site 445932003769 L27 interface [polypeptide binding]; other site 445932003770 L5 interface [polypeptide binding]; other site 445932003771 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 445932003772 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 445932003773 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 445932003774 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 445932003775 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 445932003776 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 445932003777 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 445932003778 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 445932003779 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 445932003780 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 445932003781 RNA binding site [nucleotide binding]; other site 445932003782 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 445932003783 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 445932003784 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 445932003785 putative translocon interaction site; other site 445932003786 signal recognition particle (SRP54) interaction site; other site 445932003787 L23 interface [polypeptide binding]; other site 445932003788 trigger factor interaction site; other site 445932003789 23S rRNA interface [nucleotide binding]; other site 445932003790 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 445932003791 23S rRNA interface [nucleotide binding]; other site 445932003792 5S rRNA interface [nucleotide binding]; other site 445932003793 putative antibiotic binding site [chemical binding]; other site 445932003794 L25 interface [polypeptide binding]; other site 445932003795 L27 interface [polypeptide binding]; other site 445932003796 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 445932003797 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 445932003798 G-X-X-G motif; other site 445932003799 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 445932003800 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 445932003801 putative translocon binding site; other site 445932003802 protein-rRNA interface [nucleotide binding]; other site 445932003803 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 445932003804 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 445932003805 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 445932003806 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 445932003807 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 445932003808 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 445932003809 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 445932003810 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 445932003811 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932003812 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932003813 elongation factor Tu; Reviewed; Region: PRK00049 445932003814 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 445932003815 G1 box; other site 445932003816 GEF interaction site [polypeptide binding]; other site 445932003817 GTP/Mg2+ binding site [chemical binding]; other site 445932003818 Switch I region; other site 445932003819 G2 box; other site 445932003820 G3 box; other site 445932003821 Switch II region; other site 445932003822 G4 box; other site 445932003823 G5 box; other site 445932003824 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 445932003825 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 445932003826 Antibiotic Binding Site [chemical binding]; other site 445932003827 elongation factor G; Reviewed; Region: PRK00007 445932003828 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 445932003829 G1 box; other site 445932003830 putative GEF interaction site [polypeptide binding]; other site 445932003831 GTP/Mg2+ binding site [chemical binding]; other site 445932003832 Switch I region; other site 445932003833 G2 box; other site 445932003834 G3 box; other site 445932003835 Switch II region; other site 445932003836 G4 box; other site 445932003837 G5 box; other site 445932003838 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 445932003839 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 445932003840 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 445932003841 30S ribosomal protein S7; Validated; Region: PRK05302 445932003842 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 445932003843 S17 interaction site [polypeptide binding]; other site 445932003844 S8 interaction site; other site 445932003845 16S rRNA interaction site [nucleotide binding]; other site 445932003846 streptomycin interaction site [chemical binding]; other site 445932003847 23S rRNA interaction site [nucleotide binding]; other site 445932003848 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 445932003849 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 445932003850 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 445932003851 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 445932003852 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 445932003853 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 445932003854 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 445932003855 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 445932003856 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 445932003857 DNA binding site [nucleotide binding] 445932003858 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 445932003859 RNA polymerase beta subunit; Provisional; Region: rpoB; CHL00207 445932003860 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 445932003861 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 445932003862 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 445932003863 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 445932003864 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 445932003865 RPB3 interaction site [polypeptide binding]; other site 445932003866 RPB1 interaction site [polypeptide binding]; other site 445932003867 RPB11 interaction site [polypeptide binding]; other site 445932003868 RPB10 interaction site [polypeptide binding]; other site 445932003869 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 445932003870 peripheral dimer interface [polypeptide binding]; other site 445932003871 core dimer interface [polypeptide binding]; other site 445932003872 L10 interface [polypeptide binding]; other site 445932003873 L11 interface [polypeptide binding]; other site 445932003874 putative EF-Tu interaction site [polypeptide binding]; other site 445932003875 putative EF-G interaction site [polypeptide binding]; other site 445932003876 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 445932003877 23S rRNA interface [nucleotide binding]; other site 445932003878 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 445932003879 Flavodoxins [Energy production and conversion]; Region: FldA; COG0716 445932003880 4Fe-4S binding domain; Region: Fer4; pfam00037 445932003881 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 445932003882 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 445932003883 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 445932003884 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932003885 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 445932003886 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 445932003887 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 445932003888 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 445932003889 DNA-binding site [nucleotide binding]; DNA binding site 445932003890 RNA-binding motif; other site 445932003891 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932003892 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 445932003893 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 445932003894 active site 445932003895 Uncharacterized conserved protein [Function unknown]; Region: COG0432 445932003896 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 445932003897 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 445932003898 polymerase nucleotide-binding site; other site 445932003899 DNA-binding residues [nucleotide binding]; DNA binding site 445932003900 nucleotide binding site [chemical binding]; other site 445932003901 primase nucleotide-binding site [nucleotide binding]; other site 445932003902 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 445932003903 Beta protein; Region: Beta_protein; pfam14350 445932003904 Abortive infection C-terminus; Region: Abi_C; pfam14355 445932003905 integrase; Provisional; Region: int; PHA02601 445932003906 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 445932003907 active site 445932003908 DNA binding site [nucleotide binding] 445932003909 Int/Topo IB signature motif; other site 445932003910 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 445932003911 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 445932003912 active site 445932003913 HIGH motif; other site 445932003914 KMSKS motif; other site 445932003915 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 445932003916 anticodon binding site; other site 445932003917 tRNA binding surface [nucleotide binding]; other site 445932003918 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 445932003919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445932003920 Walker A motif; other site 445932003921 ATP binding site [chemical binding]; other site 445932003922 Walker B motif; other site 445932003923 DNA polymerase III subunit delta'; Validated; Region: PRK08485 445932003924 thymidylate kinase; Validated; Region: tmk; PRK00698 445932003925 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 445932003926 TMP-binding site; other site 445932003927 ATP-binding site [chemical binding]; other site 445932003928 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 445932003929 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 445932003930 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 445932003931 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 445932003932 dimer interface [polypeptide binding]; other site 445932003933 active site 445932003934 glycine-pyridoxal phosphate binding site [chemical binding]; other site 445932003935 folate binding site [chemical binding]; other site 445932003936 deoxyhypusine synthase-like protein; Provisional; Region: PRK02492 445932003937 deoxyhypusine synthase; Region: dhys; TIGR00321 445932003938 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 445932003939 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 445932003940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445932003941 Walker A motif; other site 445932003942 ATP binding site [chemical binding]; other site 445932003943 Walker B motif; other site 445932003944 arginine finger; other site 445932003945 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 445932003946 recombination protein RecR; Reviewed; Region: recR; PRK00076 445932003947 RecR protein; Region: RecR; pfam02132 445932003948 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 445932003949 putative active site [active] 445932003950 putative metal-binding site [ion binding]; other site 445932003951 tetramer interface [polypeptide binding]; other site 445932003952 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 445932003953 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 445932003954 Competence protein; Region: Competence; pfam03772 445932003955 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 445932003956 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 445932003957 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 445932003958 FMN binding site [chemical binding]; other site 445932003959 active site 445932003960 catalytic residues [active] 445932003961 substrate binding site [chemical binding]; other site 445932003962 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 445932003963 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 445932003964 active site 445932003965 metal binding site [ion binding]; metal-binding site 445932003966 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 445932003967 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 445932003968 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 445932003969 active site 445932003970 metal binding site [ion binding]; metal-binding site 445932003971 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 445932003972 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 445932003973 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 445932003974 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 445932003975 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 445932003976 dimer interface [polypeptide binding]; other site 445932003977 PYR/PP interface [polypeptide binding]; other site 445932003978 TPP binding site [chemical binding]; other site 445932003979 substrate binding site [chemical binding]; other site 445932003980 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 445932003981 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 445932003982 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 445932003983 TPP-binding site [chemical binding]; other site 445932003984 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 445932003985 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 445932003986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932003987 Major Facilitator Superfamily; Region: MFS_1; pfam07690 445932003988 putative substrate translocation pore; other site 445932003989 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 445932003990 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 445932003991 SurA N-terminal domain; Region: SurA_N_3; cl07813 445932003992 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 445932003993 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 445932003994 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 445932003995 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 445932003996 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 445932003997 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 445932003998 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 445932003999 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 445932004000 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 445932004001 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 445932004002 Ligand binding site [chemical binding]; other site 445932004003 Electron transfer flavoprotein domain; Region: ETF; pfam01012 445932004004 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 445932004005 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 445932004006 active site 445932004007 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932004008 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 445932004009 mRNA/rRNA interface [nucleotide binding]; other site 445932004010 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 445932004011 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 445932004012 23S rRNA interface [nucleotide binding]; other site 445932004013 L7/L12 interface [polypeptide binding]; other site 445932004014 putative thiostrepton binding site; other site 445932004015 L25 interface [polypeptide binding]; other site 445932004016 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 445932004017 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 445932004018 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 445932004019 putative homodimer interface [polypeptide binding]; other site 445932004020 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 445932004021 heterodimer interface [polypeptide binding]; other site 445932004022 homodimer interface [polypeptide binding]; other site 445932004023 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 445932004024 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 445932004025 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 445932004026 substrate binding site [chemical binding]; other site 445932004027 glutamase interaction surface [polypeptide binding]; other site 445932004028 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 445932004029 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 445932004030 putative active site [active] 445932004031 oxyanion strand; other site 445932004032 catalytic triad [active] 445932004033 elongation factor Tu; Reviewed; Region: PRK00049 445932004034 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 445932004035 G1 box; other site 445932004036 GEF interaction site [polypeptide binding]; other site 445932004037 GTP/Mg2+ binding site [chemical binding]; other site 445932004038 Switch I region; other site 445932004039 G2 box; other site 445932004040 G3 box; other site 445932004041 Switch II region; other site 445932004042 G4 box; other site 445932004043 G5 box; other site 445932004044 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 445932004045 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 445932004046 Antibiotic Binding Site [chemical binding]; other site 445932004047 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 445932004048 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 445932004049 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 445932004050 active site 445932004051 motif I; other site 445932004052 motif II; other site 445932004053 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 445932004054 seryl-tRNA synthetase; Provisional; Region: PRK05431 445932004055 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 445932004056 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 445932004057 dimer interface [polypeptide binding]; other site 445932004058 active site 445932004059 motif 1; other site 445932004060 motif 2; other site 445932004061 motif 3; other site 445932004062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 445932004063 binding surface 445932004064 TPR motif; other site 445932004065 Tetratricopeptide repeat; Region: TPR_12; pfam13424 445932004066 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 445932004067 binding surface 445932004068 TPR motif; other site 445932004069 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 445932004070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932004071 putative substrate translocation pore; other site 445932004072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 445932004073 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 445932004074 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 445932004075 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 445932004076 Zn2+ binding site [ion binding]; other site 445932004077 Mg2+ binding site [ion binding]; other site 445932004078 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 445932004079 synthetase active site [active] 445932004080 NTP binding site [chemical binding]; other site 445932004081 metal binding site [ion binding]; metal-binding site 445932004082 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 445932004083 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 445932004084 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 445932004085 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 445932004086 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 445932004087 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 445932004088 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 445932004089 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 445932004090 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 445932004091 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 445932004092 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 445932004093 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 445932004094 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 445932004095 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 445932004096 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 445932004097 FMN binding site [chemical binding]; other site 445932004098 dimer interface [polypeptide binding]; other site 445932004099 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 445932004100 ATP synthase A chain; Region: ATP-synt_A; cl00413 445932004101 ATP synthase subunit C; Region: ATP-synt_C; cl00466 445932004102 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 445932004103 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 445932004104 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 445932004105 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 445932004106 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 445932004107 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 445932004108 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 445932004109 beta subunit interaction interface [polypeptide binding]; other site 445932004110 Walker A motif; other site 445932004111 ATP binding site [chemical binding]; other site 445932004112 Walker B motif; other site 445932004113 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 445932004114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 445932004115 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 445932004116 NAD(P) binding site [chemical binding]; other site 445932004117 active site 445932004118 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 445932004119 core domain interface [polypeptide binding]; other site 445932004120 delta subunit interface [polypeptide binding]; other site 445932004121 epsilon subunit interface [polypeptide binding]; other site 445932004122 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 445932004123 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 445932004124 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 445932004125 alpha subunit interaction interface [polypeptide binding]; other site 445932004126 Walker A motif; other site 445932004127 ATP binding site [chemical binding]; other site 445932004128 Walker B motif; other site 445932004129 inhibitor binding site; inhibition site 445932004130 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 445932004131 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 445932004132 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 445932004133 gamma subunit interface [polypeptide binding]; other site 445932004134 epsilon subunit interface [polypeptide binding]; other site 445932004135 LBP interface [polypeptide binding]; other site 445932004136 recombinase A; Provisional; Region: recA; PRK09354 445932004137 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 445932004138 hexamer interface [polypeptide binding]; other site 445932004139 Walker A motif; other site 445932004140 ATP binding site [chemical binding]; other site 445932004141 Walker B motif; other site 445932004142 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 445932004143 Clp amino terminal domain; Region: Clp_N; pfam02861 445932004144 Clp amino terminal domain; Region: Clp_N; pfam02861 445932004145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445932004146 Walker A motif; other site 445932004147 ATP binding site [chemical binding]; other site 445932004148 Walker B motif; other site 445932004149 arginine finger; other site 445932004150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 445932004151 Walker A motif; other site 445932004152 ATP binding site [chemical binding]; other site 445932004153 Walker B motif; other site 445932004154 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 445932004155 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 445932004156 active site 445932004157 multimer interface [polypeptide binding]; other site 445932004158 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 445932004159 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 445932004160 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 445932004161 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 445932004162 putative active site [active] 445932004163 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 445932004164 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 445932004165 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 445932004166 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 445932004167 excinuclease ABC subunit B; Provisional; Region: PRK05298 445932004168 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 445932004169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 445932004170 ATP binding site [chemical binding]; other site 445932004171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 445932004172 nucleotide binding region [chemical binding]; other site 445932004173 ATP-binding site [chemical binding]; other site 445932004174 Ultra-violet resistance protein B; Region: UvrB; pfam12344 445932004175 UvrB/uvrC motif; Region: UVR; pfam02151 445932004176 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 445932004177 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 445932004178 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 445932004179 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 445932004180 active site 445932004181 Zn binding site [ion binding]; other site 445932004182 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; pfam01862 445932004183 agmatinase; Region: agmatinase; TIGR01230 445932004184 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 445932004185 putative active site [active] 445932004186 Mn binding site [ion binding]; other site 445932004187 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 445932004188 ParB-like nuclease domain; Region: ParBc; pfam02195 445932004189 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 445932004190 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445932004191 P-loop; other site 445932004192 Magnesium ion binding site [ion binding]; other site 445932004193 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 445932004194 Magnesium ion binding site [ion binding]; other site 445932004195 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 445932004196 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 445932004197 23S rRNA interface [nucleotide binding]; other site 445932004198 L3 interface [polypeptide binding]; other site 445932004199 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 445932004200 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 445932004201 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 445932004202 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 445932004203 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 445932004204 Ligand Binding Site [chemical binding]; other site