-- dump date 20140619_070705 -- class Genbank::CDS -- table cds_note -- id note YP_001165480.1 TIGRFAM: outer membrane autotransporter barrel domain; PFAM: Pertactin; Autotransporter beta- domain protein YP_001165482.1 PFAM: response regulator receiver; ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein YP_001165483.1 PFAM: regulatory protein, LuxR; response regulator receiver; Sigma-70, region 4 type 2 YP_001165485.1 TIGRFAM: outer membrane autotransporter barrel domain; PFAM: Pertactin; Autotransporter beta- domain protein YP_001165486.1 PFAM: polysaccharide biosynthesis protein YP_001165488.1 PFAM: regulatory protein, MarR YP_001165490.1 PFAM: Phosphomethylpyrimidine kinase type-1 YP_001165491.1 PFAM: alanine racemase domain protein YP_001165492.1 PFAM: regulatory protein GntR, HTH; aminotransferase, class I and II YP_001165493.1 Catalyzes the transfer of the ammonia group from glutamine to a new carbon-nitrogen group YP_001165494.1 PFAM: plasmid stabilization system YP_001165495.1 TIGRFAM: putative addiction module antidote protein, CC2985 family; PFAM: CopG domain protein DNA-binding domain protein; protein of unknown function UPF0156 YP_001165498.1 PFAM: helix-turn-helix- domain containing protein, AraC type; AraC-type transcriptional regulator domain protein YP_001165499.1 PFAM: NADH:flavin oxidoreductase/NADH oxidase YP_001165500.1 PFAM: aldo/keto reductase YP_001165501.1 PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001165502.1 PFAM: Resolvase, N-terminal domain; Resolvase helix-turn-helix domain protein YP_001165503.1 PFAM: transposase Tn3 family protein YP_001165504.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001165505.1 Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor YP_001165508.1 PFAM: phage integrase family protein YP_001165512.1 PFAM: protein of unknown function DUF323 YP_001165513.1 PFAM: protein of unknown function DUF214 YP_001165514.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001165515.1 PFAM: von Willebrand factor, type A YP_001165518.1 PFAM: virulence protein SrfB YP_001165520.1 PFAM: von Willebrand factor, type A YP_001165523.1 PFAM: UspA domain protein YP_001165524.1 PFAM: putative carbohydrate binding; glycosyltransferase 36; glycosyltransferase 36 associated YP_001165526.1 PFAM: protein of unknown function DUF892 YP_001165527.1 PFAM: GnsAGnsB family protein YP_001165528.1 PFAM: initiator RepB protein YP_001165529.1 PFAM: Cobyrinic acid a,c-diamide synthase YP_001165530.1 SopB YP_001165533.1 PFAM: NADPH-dependent FMN reductase YP_001165534.1 regulates the expression of of the arsRBC involved in resistance to arsenic YP_001165535.1 TIGRFAM: arsenical pump membrane protein; PFAM: Arsenical pump membrane protein; Citrate transporter YP_001165536.1 TIGRFAM: arsenate reductase; PFAM: arsenate reductase and related YP_001165537.1 PFAM: Hok/gef cell toxic protein YP_001165539.1 PFAM: regulatory protein, MerR YP_001165540.1 PFAM: major facilitator superfamily MFS_1 YP_001165541.1 Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor YP_001165544.1 PFAM: sulfotransferase; TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein YP_001165546.1 TIGRFAM: outer membrane autotransporter barrel domain; PFAM: Autotransporter beta- domain protein YP_001165549.1 PFAM: Hok/gef cell toxic protein YP_001165552.1 PFAM: ParB domain protein nuclease YP_001165554.1 PsiA YP_001165558.1 PFAM: protein of unknown function DUF932 YP_001165559.1 PFAM: Lytic transglycosylase, catalytic YP_001165563.1 PFAM: TraL family protein YP_001165564.1 PFAM: TraE family protein YP_001165565.1 PFAM: TraK family protein YP_001165566.1 PFAM: TraB pilus assembly family protein YP_001165568.1 TIGRFAM: membrane lipoprotein lipid attachment site YP_001165569.1 similar to VirB4 YP_001165575.1 PFAM: TraU family protein YP_001165577.1 TraN; TrhN; involved in stabilizing mating pairs during plasmid conjugation; F plasmid TraN appears to recognize OmpA in the recipient cell YP_001165578.1 type IV secretion system pilus assembly protein; similar to F plasmid TraF YP_001165582.1 PFAM: TraH family protein YP_001165583.1 PFAM: TraG domain protein YP_001165585.1 PFAM: TraT complement resistance family protein YP_001165588.1 cleaves origin of transfer and unwinds; oriT relaxase YP_001165589.1 PFAM: DSBA oxidoreductase YP_001165591.1 PFAM: TraX family protein YP_001165593.1 TIGRFAM: addiction module toxin, RelE/StbE family; PFAM: plasmid stabilization system YP_001165594.1 PFAM: protein of unknown function DUF172 YP_001165596.1 PFAM: YadA C-terminal domain protein YP_001165599.1 PFAM: Integrase, catalytic region YP_001165600.1 PFAM: transposase IS3/IS911 family protein YP_001165601.1 PFAM: Cobyrinic acid a,c-diamide synthase YP_001165602.1 PFAM: phage integrase family protein YP_001174742.1 KEGG: ecv:APECO1_2755 chromosomal replication initiation protein; TIGRFAM: chromosomal replication initiator protein DnaA; PFAM: Chromosomal replication initiator, DnaA C-terminal domain; Chromosomal replication initiator, DnaA; SMART: AAA ATPase YP_001174743.1 binds the polymerase to DNA and acts as a sliding clamp YP_001174744.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_001174745.1 negatively supercoils closed circular double-stranded DNA YP_001174746.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins YP_001174747.1 PFAM: regulatory protein GntR, HTH; GntR domain protein; KEGG: sfx:S4002 regulator protein for dgo operon YP_001174748.1 PFAM: 2-keto-3-deoxy-galactonokinase; KEGG: ssn:SSO_3644 2-oxo-3-deoxygalactonate kinase YP_001174749.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism YP_001174750.1 PFAM: Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein; Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein; KEGG: stm:STM3828 2-oxo-3-deoxygalactonate 6-phosphate aldolase/galactonate dehydratase YP_001174751.1 TIGRFAM: phosphoglycerate transporter; d-galactonate transporter; PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: stm:STM3827 MFS family, D-galactonate transport protein YP_001174752.1 KEGG: spt:SPA3661 ATP/GTP-binding protein YP_001174753.1 PFAM: protein of unknown function DUF1375; KEGG: ssn:SSO_3639 hypothetical protein YP_001174754.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress YP_001174755.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent YP_001174756.1 TIGRFAM: YidE/YbjL duplication; PFAM: TrkA-C domain protein; YidE/YbjL duplication domain protein; KEGG: stt:t3711 membrane protein YP_001174757.1 PFAM: regulatory protein GntR, HTH; UbiC transcription regulator-associated domain protein; KEGG: sdy:SDY_4170 transcriptional regulator YP_001174758.1 KEGG: ecs:ECs4623 PTS system arbutin-like IIC component; TIGRFAM: PTS system, maltose and glucose-specific subfamily, IIC subunit; PTS system, alpha-glucoside-specific IIBC subunit; PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS, EIIB protein; phosphotransferase system, EIIC YP_001174759.1 PFAM: glycoside hydrolase, family 4; KEGG: ece:Z5177 6-phospho-beta-glucosidase YP_001174760.1 PFAM: protein of unknown function DUF202; KEGG: sdy:SDY_4160 hypothetical protein YP_001174761.1 KEGG: sbo:SBO_3694 hypothetical protein YP_001174762.1 catalyzes the formation of pyruvate from serine YP_001174763.1 KEGG: stt:t3718 hypothetical protein YP_001174764.1 multidrug efflux protein involved in adaptation to low energy shock YP_001174765.1 PFAM: GCN5-related N-acetyltransferase; KEGG: mlo:mll2713 hypothetical protein YP_001174766.1 TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: sbo:SBO_3698 acetolactate synthase I valine-sensitive large subunit YP_001174767.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit YP_001174768.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter YP_001174769.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph YP_001174770.1 membrane protein regulates uhpT expression YP_001174771.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate YP_001174772.1 PFAM: protein of unknown function DUF1198; KEGG: stm:STM3786 inner membrane protein YP_001174773.1 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS YP_001174774.1 TIGRFAM: carboxylate/amino acid/amine transporter; PFAM: protein of unknown function DUF6, transmembrane; KEGG: ecs:ECs4594 permease transporter YP_001174775.1 KEGG: eca:ECA2490 maltoporin YP_001174776.1 PFAM: phosphotransferase system PTS, lactose/cellobiose-specific IIA subunit; KEGG: eca:ECA2489 PTS system, cellobiose-specific IIa component YP_001174777.1 PFAM: glycoside hydrolase, family 1; KEGG: stm:STM3775 glycosyl hydrolase family YP_001174778.1 TIGRFAM: PTS system, lactose/cellobiose family IIC subunit; PFAM: phosphotransferase system, EIIC; KEGG: yen:YE1293 PTS system protein YP_001174779.1 PFAM: phosphotransferase system, lactose/cellobiose-specific IIB subunit; KEGG: yen:YE1294 exported PTS system protein YP_001174780.1 PFAM: regulatory protein, LacI; KEGG: yen:YE1295 LacI-family transcriptional regulatory protein YP_001174781.1 KEGG: ecv:APECO1_2791 hypothetical protein YP_001174782.1 PFAM: GCN5-related N-acetyltransferase; KEGG: spt:SPA1015 acetyltransferase YP_001174783.1 PFAM: regulatory protein, TetR; KEGG: bxe:Bxe_B1778 transcriptional regulator, TetR family YP_001174784.1 TIGRFAM: drug resistance transporter, EmrB/QacA subfamily; PFAM: major facilitator superfamily MFS_1; KEGG: bur:Bcep18194_B1157 drug resistance transporter EmrB/QacA subfamily YP_001174785.1 KEGG: cvi:CV0390 hypothetical protein YP_001174786.1 KEGG: cvi:CV0391 methylated-DNA-[protein]-cysteine S-methyltransferase; TIGRFAM: methylated-DNA--protein-cysteine methyltransferase; PFAM: methylated-DNA-[protein]-cysteine S-methyltransferase; Ada, metal-binding domain protein; SMART: helix-turn-helix- domain containing protein, AraC type YP_001174787.1 TIGRFAM: lipoprotein, YaeC family; PFAM: NLPA lipoprotein; KEGG: ecj:JW3635 cytoplasmic membrane lipoprotein-28 YP_001174788.1 KEGG: rso:RSc0206 hypothetical signal peptide protein YP_001174789.1 PFAM: major facilitator superfamily MFS_1; KEGG: ecs:ECs0311 transport protein YP_001174790.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: xfa:XF1752 transcriptional regulator (LysR family) YP_001174791.1 KEGG: ecs:ECs0400 hypothetical protein YP_001174792.1 PFAM: helix-turn-helix- domain containing protein, AraC type; ThiJ/PfpI domain protein; KEGG: ecs:ECs0399 transcriptional regulator YP_001174793.1 PFAM: Hemolysin activator HlyB domain protein; Polypeptide-transport-associated domain protein, ShlB-type; KEGG: ecp:ECP_4581 hemolysin activator HlyB YP_001174794.1 TIGRFAM: filamentous haemagglutinin family outer membrane protein; adhesin HecA family; PFAM: Haemagluttinin repeat-containing protein; filamentous haemagglutinin domain protein; KEGG: ecc:c0345 member of ShlA/HecA/FhaA exoprotein family YP_001174795.1 KEGG: eci:UTI89_C4946 member of ShlA/HecA/FhaA exoprotein family YP_001174797.1 KEGG: plu:plu1350 hypothetical protein YP_001174798.1 KEGG: pae:PA2462 hypothetical protein YP_001174799.1 KEGG: ecp:ECP_4580 probable hemagglutinin-related protein YP_001174800.1 KEGG: ecp:ECP_4579 hypothetical protein YP_001174801.1 PFAM: Integrase, catalytic region; KEGG: sfv:SFV_0556 ISEhe3 orfB YP_001174802.1 KEGG: eca:ECA2127 hypothetical protein YP_001174803.1 PFAM: protein of unknown function DUF523; Protein of unknown function DUF1722; KEGG: sec:SC159 pathogenicity island protein YP_001174804.1 PFAM: Transthyretin; KEGG: sec:SC158 hypothetical protein YP_001174805.1 PFAM: regulatory protein, MerR; KEGG: sec:SC157 transcriptional regulator YP_001174806.1 lipocalin; globomycin-sensitive outer membrane lipoprotein YP_001174807.1 KEGG: lbl:LBL_1823 methyltransferase YP_001174808.1 KEGG: eca:ECA3392 hypothetical protein YP_001174809.1 KEGG: plu:plu4874 hypothetical protein YP_001174810.1 KEGG: ecc:c0933 hypothetical protein YP_001174811.1 may be involved in the transport of galactosides-pentoses-hexuronides YP_001174812.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides YP_001174813.1 PFAM: AsmA family protein; KEGG: spt:SPA3599 hypothetical protein YP_001174814.1 TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: stm:STM3747 NCS2 family, purine/xanthine transport protein YP_001174815.1 PFAM: Fimbrial protein YP_001174816.1 PFAM: Fimbrial protein YP_001174819.1 PFAM: Fimbrial protein YP_001174820.1 PFAM: Fimbrial protein; KEGG: ecs:ECs4431 fimbrial major protein precursor YP_001174823.1 PFAM: Fimbrial protein YP_001174824.1 PFAM: Fimbrial protein; KEGG: ssn:SSO_1621 adhesin YP_001174825.1 PFAM: fimbrial biogenesis outer membrane usher protein; KEGG: yen:YE1112 outer membrane usher protein YP_001174826.1 PFAM: pili assembly chaperone; KEGG: stm:STM4594 fimbrial chaparone YP_001174827.1 PFAM: Fimbrial protein YP_001174828.1 catalyzes branch migration in Holliday junction intermediates YP_001174829.1 specifically modifies tRNA at position G18 YP_001174830.1 KEGG: ecp:ECP_3748 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; TIGRFAM: RelA/SpoT family protein; PFAM: TGS domain protein; metal-dependent phosphohydrolase, HD sub domain; RelA/SpoT domain protein; SMART: metal-dependent phosphohydrolase, HD region YP_001174831.1 TIGRFAM: DNA-directed RNA polymerase, omega subunit; PFAM: RNA polymerase Rpb6; KEGG: sdy:SDY_4081 DNA-directed RNA polymerase omega chain YP_001174832.1 Essential for recycling GMP and indirectly, cGMP YP_001174833.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+ YP_001174834.1 PFAM: sulfatase; KEGG: bpe:BP2327 outer membrane protein YP_001174835.1 PFAM: protein of unknown function UPF0126; KEGG: stm:STM3738 inner membrane protein YP_001174836.1 PFAM: YicC N-terminal domain protein; domain of unknown function DUF1732; KEGG: stm:STM3735 stress-induced protein YP_001174837.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_001174838.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001174839.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly YP_001174840.1 catalyzes the formation of dUMP from dUTP YP_001174841.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_001174842.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_001174843.1 required for 70S ribosome assembly YP_001174844.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001174845.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_001174846.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_001174847.1 PFAM: glycosyl transferase, family 2; KEGG: yen:YE0068 lipopolysaccharide core biosynthesis glycosyl transferase YP_001174848.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_001174849.1 PFAM: sulfatase; KEGG: nme:NMB2010 YhbX/YhjW/YijP/YjdB family protein YP_001174850.1 KEGG: dvl:Dvul_2391 hypothetical protein YP_001174851.1 PFAM: glycosyl transferase, family 2; KEGG: plu:plu4290 unnamed protein product; similar to glycosyltransferase YP_001174853.1 PFAM: glycosyl transferase, group 1; KEGG: mgm:Mmc1_1923 glycosyl transferase, group 1 YP_001174854.1 PFAM: glycosyl transferase, group 1; KEGG: cvi:CV0817 probable glycosyltransferase YP_001174855.1 TIGRFAM: lipopolysaccharide heptosyltransferase III, PFAM: glycosyl transferase, family 9; KEGG: dar:Daro_0152 lipopolysaccharide heptosyltransferase III YP_001174856.1 TIGRFAM: lipopolysaccharide heptosyltransferase I; PFAM: glycosyl transferase, family 9; KEGG: ssn:SSO_3784 heptosyl transferase I YP_001174857.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core YP_001174858.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose YP_001174859.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_001174860.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism YP_001174861.1 PFAM: glycosyl transferase, family 2; KEGG: dar:Daro_3929 glycosyl transferase, family 2 YP_001174862.1 PFAM: protein of unknown function DUF610, YibQ; KEGG: stm:STM3706 periplasmic protein YP_001174863.1 PFAM: peptidase M23B; KEGG: stm:STM3705 hypothetical protein YP_001174864.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_001174865.1 PFAM: Rhodanese domain protein; KEGG: stm:STM3703 rhodanese-like sulfurtransferase YP_001174866.1 TIGRFAM: glutaredoxin 3; PFAM: glutaredoxin; KEGG: sdy:SDY_4043 glutaredoxin 3 YP_001174867.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_001174868.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_001174869.1 catalyzes the O-acetylation of serine YP_001174870.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates YP_001174871.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration YP_001174872.1 represses the lctPRD operon YP_001174873.1 TIGRFAM: L-lactate transport; PFAM: L-lactate permease; KEGG: stm:STM3692 LctP transporter, L-lactate permease YP_001174874.1 KEGG: sbo:SBO_3601 hypothetical protein YP_001174875.1 Acts as a repressor of the mtlAD operon YP_001174876.1 PFAM: Mannitol dehydrogenase, C-terminal domain; Mannitol dehydrogenase rossman, N-terminal domain; KEGG: sec:SC3610 mannitol-1-phosphate dehydrogenase YP_001174877.1 TIGRFAM: PTS system, mannitol-specific IIC subunit; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; phosphotransferase system, EIIC; phosphotransferase system, lactose/cellobiose-specific IIB subunit; KEGG: ecv:APECO1_2858 fused mannitol-specific PTS enzymes: IIA components/IIB components/IIC components YP_001174878.1 KEGG: ecp:ECP_3696 hypothetical protein YibI YP_001174879.1 PFAM: secretion protein HlyD family protein; KEGG: eci:UTI89_C4135 hypothetical protein YibH YP_001174880.1 PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain; KEGG: spt:SPA3535 glutathione transferase YP_001174881.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis YP_001174882.1 TIGRFAM: selenocysteine-specific translation elongation factor; PFAM: protein synthesis factor, GTP-binding; elongation factor Tu, domain 2 protein; translation elongation factor, selenocysteine-specific; KEGG: ecv:APECO1_2863 selenocysteinyl-tRNA-specific translation factor YP_001174883.1 PFAM: iron-containing alcohol dehydrogenase; KEGG: ecc:c4410 probable alcohol dehydrogenase YP_001174884.1 PFAM: aldehyde dehydrogenase; KEGG: stm:STM3680 aldehyde dehydrogenase B YP_001174885.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: ecs:ECs4461 transcriptional regulator LysR-type YP_001174886.1 PFAM: MltA-interacting MipA family protein; KEGG: sfv:SFV_3952 outer membrane protein YP_001174887.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: ecv:APECO1_2877 electron transport protein YsaA YP_001174888.1 PFAM: Polypeptide-transport-associated domain protein, ShlB-type; KEGG: yen:YE0480 exported protein YP_001174889.1 KEGG: yen:YE0479 lipoprotein YP_001174890.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis YP_001174891.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds YP_001174892.1 PFAM: Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase; SMART: Lysozyme subfamily 2; KEGG: stm:STM3663 gene transcribed divergently from malS YP_001174893.1 PFAM: helix-turn-helix- domain containing protein, AraC type; KEGG: ecv:APECO1_2881 DNA-binding transcriptional activator, xylose-binding YP_001174894.1 PFAM: inner-membrane translocator; KEGG: sbo:SBO_3576 xylose transport, membrane component YP_001174895.1 with XylFH is part of the high affinity xylose ABC transporter YP_001174896.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity YP_001174897.1 catalyzes the interconversion of D-xylose to D-xylulose YP_001174898.1 TIGRFAM: xylulokinase; PFAM: carbohydrate kinase, FGGY; KEGG: ecs:ECs4447 xylulokinase YP_001174899.1 PFAM: isochorismatase hydrolase; KEGG: cvi:CV1902 probable hydrolase YP_001174900.1 PFAM: helix-turn-helix- domain containing protein, AraC type; ThiJ/PfpI domain protein; KEGG: cvi:CV1905 probable transcription regulator YP_001174901.1 PFAM: acyltransferase 3; KEGG: sfv:SFV_3979 hypothetical protein YP_001174902.1 KEGG: sdy:SDY_4343 hypothetical protein YP_001174903.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001174904.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001174905.1 SMART: helix-turn-helix domain protein; KEGG: stm:STM3648 transcriptional regulator YP_001174906.1 KEGG: stm:STM3647 outer membrane lipoprotein YP_001174907.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein; KEGG: sdy:SDY_4347 cold shock protein 7.4 YP_001174908.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: ecv:APECO1_2895 2-ketoaldonate reductase/glyoxylate reductase B YP_001174909.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: bam:Bamb_1653 major facilitator superfamily MFS_1 YP_001174910.1 PFAM: PfkB domain protein; KEGG: bur:Bcep18194_A5029 sugar kinase, ribokinase family YP_001174911.1 PFAM: Xylose isomerase domain protein TIM barrel; KEGG: pau:PA14_35360 epimerase YP_001174912.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: bch:Bcen2424_1729 transcriptional regulator, LacI family YP_001174913.1 PFAM: OmpA/MotB domain protein; 17 kDa surface antigen; KEGG: stm:STM3645 outer membrane lipoprotein YP_001174914.1 KEGG: ecc:c4369 biotin sulfoxide reductase; TIGRFAM: molybdopterin guanine dinucleotide-containing S/N-oxide reductase; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region YP_001174915.1 PFAM: GCN5-related N-acetyltransferase; KEGG: stt:t3876 acetyltransferase YP_001174916.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine YP_001174917.1 KEGG: stm:STM3641 lipase YP_001174918.1 TIGRFAM: Oxalate/Formate Antiporter; PFAM: major facilitator superfamily MFS_1; KEGG: ecv:APECO1_2901 transporter YP_001174919.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide YP_001174920.1 PFAM: Rhs element Vgr protein; KEGG: ypn:YPN_2507 hypothetical protein YP_001174921.1 PFAM: Peptidoglycan-binding LysM YP_001174925.1 PFAM: extracellular solute-binding protein, family 5; KEGG: stm:STM3630 ABC superfamily (peri_perm), dipeptide transport protein YP_001174926.1 transports peptides consisting of two or three amino acids YP_001174927.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: sfx:S4193 dipeptide transport system permease 2 YP_001174928.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF YP_001174929.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides YP_001174930.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_001174931.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001174932.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_001174933.1 Modulates Rho-dependent transcription termination YP_001174934.1 binds directly to 23S ribosomal RNA YP_001174935.1 PFAM: ribosomal protein L1; KEGG: sdy:SDY_3744 50S ribosomal subunit protein L1 YP_001174936.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001174937.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001174938.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001174939.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001174940.1 PFAM: phosphotransferase system PTS, lactose/cellobiose-specific IIA subunit; KEGG: plu:plu2756 PTS system, cellobiose-specific IIA component (EIIA-CEL) (cellobiose-permease IIA component) (phosphotransferase enzyme II, A component) (EIII-CEL) YP_001174941.1 PFAM: phosphotransferase system, lactose/cellobiose-specific IIB subunit; KEGG: plu:plu2754 PTS system, cellobiose-specific IIB component YP_001174942.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein; KEGG: ypn:YPN_3526 major cold shock protein CspA1 YP_001174943.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center YP_001174944.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_001174945.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate YP_001174946.1 PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: spt:SPA3999 thiamine biosynthesis protein YP_001174947.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate YP_001174948.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_001174949.1 binds specifically to the major sigma factor sigma 70; active in stationary phase YP_001174950.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates YP_001174951.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_001174952.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures YP_001174953.1 PFAM: protein of unknown function DUF416; KEGG: stm:STM4169 cytoplasmic protein YP_001174954.1 histone-like DNA-binding protein YP_001174955.1 PFAM: protein of unknown function DUF1481; KEGG: stt:t3460 hypothetical protein YP_001174956.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_001174957.1 involved in de novo purine biosynthesis YP_001174958.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_001174959.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle YP_001174960.1 TIGRFAM: isocitrate lyase; PFAM: isocitrate lyase and phosphorylmutase; KEGG: spt:SPA4022 isocitrate lyase YP_001174961.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol YP_001174962.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase YP_001174963.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_001174964.1 TIGRFAM: sodium-dependent inorganic phosphate (Pi) transporter; Na/Pi-cotransporter II-related protein; PFAM: Na+/Pi-cotransporter; KEGG: ecp:ECP_4231 hypothetical protein YjbB YP_001174965.1 KEGG: rru:Rru_A0456 predicted transcriptional regulator YP_001174966.1 PFAM: protein of unknown function DUF891; KEGG: maq:Maqu_2671 protein of unknown function DUF891 YP_001174967.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA YP_001174968.1 KEGG: stm:STM4194 cytoplasmic protein YP_001174969.1 PFAM: Bile acid:sodium symporter; KEGG: stm:STM4195 Na+-dependent transporter YP_001174970.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive YP_001174971.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_001174972.1 KEGG: ssn:SSO_4204 hypothetical protein YP_001174973.1 KEGG: ecj:JW5711 predicted lipoprotein YP_001174974.1 PFAM: protein of unknown function DUF1017; KEGG: ecp:ECP_4246 hypothetical protein YjbG precursor YP_001174975.1 PFAM: protein of unknown function DUF940, membrane lipoprotein KEGG: ecj:JW3989 predicted porin YP_001174976.1 PFAM: phosphate-starvation-inducible E; KEGG: sdy:SDY_4218 hypothetical protein YP_001174977.1 with MalKFE is involved in the transport of maltose into the cell YP_001174978.1 with MalKGE is involved in maltose transport into the cell YP_001174979.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis YP_001174980.1 with malEFG is involved in import of maltose/maltodextrin YP_001174981.1 porin involved in the transport of maltose and maltodextrins YP_001174982.1 PFAM: Maltose operon periplasmic; KEGG: ecv:APECO1_2431 maltose operon periplasmic protein precursor MalM YP_001174983.1 catalyzes the formation of 4-hydroxybenzoate from chorismate YP_001174984.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway YP_001174985.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_001174986.1 PFAM: diacylglycerol kinase; KEGG: sdy:SDY_4532 diacylglycerol kinase YP_001174987.1 Represses a number of genes involved in the response to DNA damage YP_001174988.1 TIGRFAM: MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE; KEGG: sfv:SFV_4169 DNA-damage-inducible protein F YP_001174989.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential YP_001174990.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB YP_001174991.1 KEGG: bur:Bcep18194_B0904 hypothetical protein YP_001174992.1 KEGG: stm:STM4242 conjugative transfer protein YP_001174993.1 TIGRFAM: TIM-barrel protein, yjbN family; PFAM: dihydrouridine synthase, DuS; KEGG: ecv:APECO1_2423 tRNA-dihydrouridine synthase A YP_001174994.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia YP_001174995.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: ecs:ECs5033 quinone oxidoreductase YP_001174996.1 unwinds double stranded DNA YP_001174997.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_001174998.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_001174999.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity YP_001175000.1 PFAM: protein of unknown function DUF419; KEGG: sec:SC4130 cytoplasmic protein YP_001175001.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_001175002.1 binds to single stranded DNA and PriA helcase facilitate replication restart YP_001175003.1 KEGG: stm:STM4263 inner membrane protein YP_001175004.1 TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: bpa:BPP1614 hypothetical protein YP_001175005.1 PFAM: EAL domain protein; KEGG: spt:SPA4080 hypothetical protein YP_001175006.1 regulates genes involved in response to oxidative stress YP_001175007.1 TIGRFAM: redox-sensitive transcriptional activator SoxR; PFAM: regulatory protein, MerR; Redox-sensitive transcriptional activator SoxR; KEGG: sdy:SDY_4504 redox-sensing activator of SoxS YP_001175008.1 PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain; KEGG: stt:t4173 glutathione S transferase YP_001175009.1 PFAM: Xanthine/uracil/vitamin C permease; sulphate transporter; KEGG: spt:SPA4085 xanthine/uracil permeases family protein YP_001175010.1 TIGRFAM: Na+/H+ antiporter; PFAM: sodium/hydrogen exchanger; KEGG: ecv:APECO1_2392 sodium/hydrogen exchanger family protein YjcE YP_001175011.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: sec:SC4149 transcriptional regulator, LysR family YP_001175012.1 PFAM: LrgA family protein; KEGG: stm:STM4271 inner membrane protein YP_001175013.1 PFAM: LrgB family protein; KEGG: stm:STM4272 inner membrane protein YP_001175014.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake YP_001175015.1 PFAM: protein of unknown function DUF485; KEGG: sec:SC4153 inner membrane protein YP_001175016.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_001175017.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system YP_001175018.1 PFAM: Sel1 domain protein repeat-containing protein; KEGG: stm:STM4284 TPR repeat protein YP_001175019.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KEGG: bam:Bamb_6404 short-chain dehydrogenase/reductase SDR YP_001175020.1 PFAM: helix-turn-helix, HxlR type; KEGG: bam:Bamb_6402 transcriptional regulator, HxlR family YP_001175021.1 TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; KEGG: spt:SPA4103 formate dehydrogenase H YP_001175022.1 PFAM: molybdopterin oxidoreductase Fe4S4 region; KEGG: stm:STM4285 formate dehydrogenase YP_001175023.1 PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: yps:YPTB3801 response regulator protein YP_001175024.1 PFAM: PfkB domain protein; KEGG: sdy:SDY_4133 kinase YP_001175025.1 KEGG: ecs:ECs5069 fructose-bisphosphate aldolase; TIGRFAM: ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase, class-II YP_001175026.1 PFAM: protein of unknown function DUF1498; KEGG: ecs:ECs5070 hypothetical protein YP_001175027.1 PFAM: periplasmic binding protein/LacI transcriptional regulator; KEGG: ecs:ECs5071 carbohydrate binding protein YP_001175028.1 PFAM: inner-membrane translocator; KEGG: ecs:ECs5072 carbohydrate ABC transport system permease YP_001175029.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: ecs:ECs5073 ATP-binding component of sugar ABC transporter YP_001175030.1 PFAM: response regulator receiver; ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: sdy:SDY_4127 histidine kinase YP_001175031.1 KEGG: sdy:SDY_4126 hypothetical protein YP_001175032.1 KEGG: sbo:SBO_4117 hypothetical protein YP_001175033.1 might be involved in hypersensitivity to nitrofurzone YP_001175034.1 PFAM: helix-turn-helix domain protein; KEGG: sdy:SDY_2913 hypothetical protein YP_001175035.1 KEGG: ssn:SSO_2862 cytoplasmic protein YP_001175036.1 required for the use of phosphonates and phosphite as phosphorus sources YP_001175037.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role YP_001175038.1 TIGRFAM: phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN; SMART: guanylate kinase/L-type calcium channel region; KEGG: ssn:SSO_4270 ATP-binding component of phosphonate transport YP_001175039.1 TIGRFAM: phosphonate metabolism protein PhnM; PFAM: amidohydrolase; Amidohydrolase 3; KEGG: ssn:SSO_4271 phosphonate metabolism YP_001175040.1 KEGG: ecc:c5102 phosphonates transport ATP-binding protein phnL; TIGRFAM: phosphonate C-P lyase system protein PhnL; PFAM: ABC transporter related; SMART: AAA ATPase YP_001175041.1 KEGG: ecp:ECP_4340 phosphonates transport ATP-binding protein PhnK; TIGRFAM: phosphonate C-P lyase system protein PhnK; PFAM: ABC transporter related; SMART: AAA ATPase YP_001175042.1 PFAM: phosphonate metabolism PhnJ; KEGG: sbo:SBO_4124 PhnJ YP_001175043.1 PFAM: phosphonate metabolism; KEGG: ecs:ECs5082 phosphonate metabolism YP_001175044.1 PFAM: phosphonate metabolism; KEGG: ecj:JW4061 carbon-phosphorus lyase complex subunit YP_001175045.1 PFAM: phosphonate metabolism PhnG; KEGG: ecp:ECP_4344 PhnG protein YP_001175046.1 may be involved in phosphonate uptake and biodegradation YP_001175047.1 TIGRFAM: phosphonate ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ecp:ECP_4346 phosphonates transport system permease PhnE YP_001175048.1 TIGRFAM: phosphonate ABC transporter, periplasmic phosphonate-binding protein; KEGG: ecv:APECO1_2346 PhnD, subunit of alkylphosphonate ABC transporter YP_001175049.1 KEGG: ecp:ECP_4348 HisP-like nucleotide binding protein (PhnC); TIGRFAM: phosphonate ABC transporter, ATPase subunit; PFAM: ABC transporter related; SMART: AAA ATPase YP_001175050.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: ecp:ECP_4349 PhnB protein YP_001175051.1 TIGRFAM: alkylphosphonate utilization operon protein PhnA; PFAM: PhnA protein-like; KEGG: stm:STM4289 alkylphosphonate uptake protein in phosphonate metabolism YP_001175052.1 KEGG: ecj:JW4070 conserved hypothetical protein with nucleoside triphosphate hydrolase domain YP_001175053.1 KEGG: ecs:ECs5092 hypothetical protein YP_001175054.1 transports degraded pectin products into the bacterial cell YP_001175055.1 TIGRFAM: metabolite/H+ symporter, major facilitator superfamily (MFS); PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: ssn:SSO_4286 low-affinity transport system YP_001175056.1 PFAM: high-affinity nickel-transporter; KEGG: yps:YPTB2863 hypothetical protein YP_001175057.1 KEGG: bxe:Bxe_A3282 hypothetical protein YP_001175058.1 TIGRFAM: outer membrane autotransporter barrel domain; PFAM: Pertactin; Autotransporter beta- domain protein; KEGG: ecs:ECs0362 AidA-I adhesin-like protein YP_001175059.1 KEGG: ypn:YPN_3709 methyl-accepting chemotaxis protein II YP_001175060.1 PFAM: helix-turn-helix- domain containing protein, AraC type; AraC protein, arabinose-binding/dimerisation; KEGG: eca:ECA0615 AraC-family transcriptional regulator YP_001175061.1 KEGG: ssn:SSO_4318 hypothetical protein YP_001175062.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm YP_001175063.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals YP_001175064.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB YP_001175065.1 catalyzes the formation of fumarate from aspartate YP_001175066.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein YP_001175067.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function YP_001175068.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_001175069.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001175070.1 KEGG: stm:STM4331 outer membrane lipoprotein YP_001175071.1 TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein; KEGG: ecv:APECO1_2243 lysine aminomutase YP_001175072.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001175073.1 PFAM: Entericidin EcnAB YP_001175074.1 PFAM: Entericidin EcnAB; KEGG: ssn:SSO_4333 toxin of osmotically regulated toxin-antitoxin system associated with programmed cell death YP_001175075.1 PFAM: regulatory protein, LuxR; KEGG: stm:STM4337 regulatory protein YP_001175076.1 member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations YP_001175077.1 lipocalin; globomycin-sensitive outer membrane lipoprotein YP_001175078.1 PFAM: beta-lactamase; KEGG: sec:SC090 extended spectrum beta-lactamase YP_001175079.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane YP_001175080.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001175081.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001175082.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001175083.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001175084.1 PFAM: MscS Mechanosensitive ion channel; KEGG: sbo:SBO_4298 periplasmic binding protein YP_001175085.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine YP_001175086.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_001175087.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_001175088.1 TIGRFAM: iron-sulfur cluster binding protein; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; domain of unknown function DUF1730; KEGG: stm:STM4355.S FeS protein YP_001175089.1 TIGRFAM: carbohydrate kinase, YjeF related protein; PFAM: protein of unknown function UPF0031; YjeF-family N-terminal domain protein; KEGG: sec:SC4232 sugar kinase YP_001175090.1 possibly involved in cell wall synthesis YP_001175091.1 PFAM: cell wall hydrolase/autolysin; KEGG: spt:SPA4175 N-acetylmuramoyl-L-alanine amidase YP_001175092.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_001175093.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001175094.1 Stimulates the elongation of poly(A) tails YP_001175095.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein YP_001175096.1 with HflC inhibits proteolysis of lambda cII protein by FtsH YP_001175097.1 with HflK inhibits proteolysis of lambda cII protein by FtsH YP_001175098.1 KEGG: sdy:SDY_4413 hypothetical protein YP_001175099.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001175100.1 negatively regulates the transcription of genes upregulated by nitrosative stress YP_001175101.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs YP_001175102.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA YP_001175103.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: sma:SAV1708 integral membrane transport protein YP_001175104.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA YP_001175105.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; KEGG: eca:ECA3615 methyl-accepting chemotaxis protein YP_001175106.1 PFAM: protein of unknown function DUF1471; KEGG: stm:STM4378 inner membrane protein YP_001175107.1 PFAM: protein of unknown function DUF1471; KEGG: stm:STM4379 lipoprotein YP_001175108.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo YP_001175109.1 PFAM: protein of unknown function DUF1471; KEGG: sbo:SBO_4255 hypothetical protein YP_001175110.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001175111.1 binds single-stranded DNA at the primosome assembly site YP_001175112.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001175113.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001175114.1 PFAM: protein of unknown function DUF6, transmembrane; KEGG: stm:STM4395 permease YP_001175115.1 PFAM: Opacity-associated protein A; Opacity-associated protein A, N-terminal domain protein; KEGG: sdy:SDY_4376 hypothetical protein YP_001175116.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides YP_001175117.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine YP_001175118.1 Involved in anaerobic NO protection and iron metabolism YP_001175119.1 PFAM: ligand binding Tar domain protein; histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; KEGG: stm:STM4533 methyl-accepting chemotaxis protein I, serine sensor receptor YP_001175120.1 PFAM: protein of unknown function DUF6, transmembrane; KEGG: ssn:SSO_4395 transmembrane subunit YP_001175121.1 PFAM: helix-turn-helix- domain containing protein, AraC type; AraC protein, arabinose-binding/dimerisation; KEGG: eca:ECA1518 AraC-family transcriptional regulator YP_001175122.1 PFAM: 3-beta hydroxysteroid dehydrogenase/isomerase; NmrA family protein; KEGG: ecs:ECs5190 oxidoreductase YP_001175123.1 PFAM: helix-turn-helix, HxlR type; KEGG: sdy:SDY_4381 hypothetical protein YP_001175124.1 PFAM: helix-turn-helix- domain containing protein, AraC type; ThiJ/PfpI domain protein; KEGG: bch:Bcen2424_6323 transcriptional regulator, AraC family YP_001175125.1 KEGG: bch:Bcen2424_6320 secreted protein YP_001175126.1 PFAM: NAD(P)H dehydrogenase (quinone); KEGG: bch:Bcen2424_3293 (acyl-carrier-protein) phosphodiesterase YP_001175127.1 KEGG: bch:Bcen2424_3292 hypothetical protein YP_001175128.1 KEGG: pst:PSPTO_0243 hypothetical protein YP_001175129.1 KEGG: eca:ECA0779 hypothetical protein YP_001175130.1 KEGG: saz:Sama_1384 streptogramin A acetyl transferase YP_001175131.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate YP_001175132.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate YP_001175133.1 KEGG: ecp:ECP_4469 protein YtfJ precursor YP_001175134.1 PFAM: protein of unknown function DUF1107; KEGG: stm:STM4406.S cytoplasmic protein YP_001175135.1 PFAM: CBS domain containing protein; protein of unknown function DUF21; transporter-associated region; KEGG: sdy:SDY_4455 transport protein YP_001175136.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_001175137.1 PFAM: surface antigen (D15); surface antigen variable number repeat protein; KEGG: stm:STM4409 outer membrane protein YP_001175138.1 PFAM: protein of unknown function DUF490; KEGG: ecj:JW4180 conserved hypothetical protein YP_001175139.1 PFAM: protein of unknown function UPF0131; KEGG: sdy:SDY_4459 hypothetical protein YP_001175140.1 PFAM: Fimbrial protein; KEGG: yen:YE0779 mannose-resistant/Proteus-like fimbrial protein YP_001175141.1 PFAM: Fimbrial protein; KEGG: plu:plu0770 MrfB protein YP_001175142.1 PFAM: fimbrial biogenesis outer membrane usher protein; KEGG: plu:plu0771 outer membrane usher protein MrfC YP_001175143.1 PFAM: pili assembly chaperone; KEGG: plu:plu0772 MrfD protein YP_001175144.1 PFAM: Fimbrial protein; KEGG: plu:plu0773 MrfX protein YP_001175146.1 PFAM: Fimbrial protein; KEGG: ecv:APECO1_4231 Yfc fimbriae subunit YfcQ precursor YP_001175147.1 PFAM: Fimbrial protein; KEGG: plu:plu0776 MrfG protein YP_001175148.1 PFAM: Fimbrial protein YP_001175149.1 PFAM: O-antigen polymerase; KEGG: yen:YE0777 inner membrane protein YP_001175150.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_001175151.1 PFAM: periplasmic binding protein/LacI transcriptional regulator; KEGG: ecp:ECP_4477 ABC transporter periplasmic binding protein YtfQ precursor YP_001175152.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: ecj:JW5752 predicted sugar transporter subunit YP_001175153.1 PFAM: inner-membrane translocator; KEGG: ecj:JW5753 predicted sugar transporter subunit YP_001175154.1 membrane component of a sugar ABC transporter system YP_001175155.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; KEGG: eca:ECA3624 methyl-accepting chemotaxis protein YP_001175156.1 PFAM: regulatory protein, LysR; KEGG: bam:Bamb_6418 transcriptional regulator, LysR family YP_001175157.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_001175158.1 TIGRFAM: UDP-N-acetylmuramate; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein; KEGG: stm:STM4416 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase YP_001175159.1 KEGG: eca:ECA4385 hypothetical protein YP_001175160.1 PFAM: protein of unknown function DUF615; KEGG: ecc:c5332 hypothetical protein YP_001175161.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD YP_001175162.1 PFAM: cytochrome b562; KEGG: ecs:ECs5213 cytochrome b(562) YP_001175163.1 PFAM: PRD domain protein; KEGG: stm:STM4440 cytoplasmic protein YP_001175164.1 KEGG: stm:STM4441 cytoplasmic protein YP_001175165.1 KEGG: stm:STM4442 cytoplasmic protein YP_001175166.1 KEGG: stm:STM4443 inner membrane protein YP_001175167.1 KEGG: stm:STM4444 inner membrane protein YP_001175168.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides YP_001175169.1 TIGRFAM: pyridoxal phosphate-dependent enzyme, PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: spt:SPA4246 hypothetical protein YP_001175170.1 PFAM: protein of unknown function DUF1341; KEGG: spt:SPA4247 hypothetical protein YP_001175171.1 KEGG: rba:RB3641 conserved hypothetical protein- cycloisomerase YP_001175172.1 PFAM: regulatory protein, DeoR; phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; M trans-acting positive regulator; PRD domain protein; Helix-turn-helix, type 11 domain protein; KEGG: stm:STM4448 phosphotransferase system mannitol/fructose-specific IIA domain YP_001175173.1 Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor YP_001175174.1 TIGRFAM: addiction module toxin, RelE/StbE family; PFAM: plasmid stabilization system; KEGG: stm:STM4450 inner membrane protein YP_001175175.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions YP_001175176.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_001175177.1 KEGG: spt:SPA4254 trehalose-6-phosphate hydrolase; TIGRFAM: alpha,alpha-phosphotrehalase; PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001175178.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001175179.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon YP_001175180.1 P-type ATPase involved in magnesium influx YP_001175181.1 PFAM: glycoside hydrolase, family 20; KEGG: ppr:PBPRA1268 beta-N-acetylhexosaminidase YP_001175183.1 KEGG: stt:t2563 hypothetical protein YP_001175184.1 TIGRFAM: endoribonuclease L-PSP; PFAM: Endoribonuclease L-PSP; KEGG: sdy:SDY_4262 hypothetical protein YP_001175185.1 involved in the allosteric regulation of aspartate carbamoyltransferase YP_001175186.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_001175187.1 PFAM: arginine repressor; KEGG: stm:STM4463 arginine repressor YP_001175188.1 PFAM: C4-dicarboxylate anaerobic carrier; KEGG: aha:AHA_4090 transporter YP_001175189.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway YP_001175190.1 reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_001175191.1 catalyzes the degradation of arginine to citruline and ammonia YP_001175192.1 PFAM: conserved hypothetical protein 22; KEGG: ecs:ECs5229 hypothetical protein YP_001175193.1 PFAM: dihydrodipicolinate synthetase; KEGG: ecj:JW0261 predicted lyase/synthase YP_001175194.1 PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: ecj:JW0262 predicted dehydratase YP_001175195.1 uncharacterized member of the GPH family of galactose-pentose-hexuronide transporters YP_001175196.1 PFAM: glycoside hydrolase, family 43; KEGG: ecj:JW0264 predicted xylosidase/arabinosidase YP_001175197.1 PFAM: regulatory protein, IclR; Helix-turn-helix, type 11 domain protein; Helix-turn-helix Mga, DNA-binding trans-acting positive regulator; KEGG: ecj:JW0265 predicted DNA-binding transcriptional regulator YP_001175198.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase; when both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III YP_001175199.1 PFAM: protein of unknown function DUF1260; KEGG: stm:STM4470 cytoplasmic protein YP_001175200.1 PFAM: tRNA--hydroxylase; KEGG: stm:STM4471 hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA YP_001175202.1 PFAM: phage integrase family protein; KEGG: eci:UTI89_C4878 prophage P4 integrase YP_001175203.1 KEGG: pha:PSHAb0089 hypothetical protein YP_001175204.1 KEGG: pha:PSHAb0090 orphan protein YP_001175205.1 KEGG: hch:HCH_07046 hypothetical protein YP_001175206.1 KEGG: abo:ABO_1657 hypothetical protein YP_001175208.1 KEGG: sdn:Sden_1984 hypothetical protein YP_001175209.1 PFAM: SMC domain protein; KEGG: hch:HCH_07044 ATPase involved in DNA repair YP_001175210.1 KEGG: hch:HCH_07043 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PapS reductase)/FAD synthetase and related enzyme YP_001175211.1 KEGG: hch:HCH_07042 hypothetical protein YP_001175212.1 KEGG: ecv:APECO1_1083 hypothetical protein YP_001175213.1 PFAM: DNA repair protein RadC; KEGG: plu:plu0133 hypothetical protein YP_001175214.1 KEGG: ecj:JW5956 hypothetical protein YP_001175215.1 PFAM: YagBYeeUYfjZ family protein; KEGG: ecv:APECO1_3487 hypothetical protein YP_001175216.1 PFAM: protein of unknown function DUF1219; KEGG: ecj:JW2627 toxin of the YpjF-YfjZ toxin-antitoxin system YP_001175217.1 KEGG: eca:ECA2852 hypothetical protein YP_001175218.1 PFAM: CopG domain protein DNA-binding domain protein; KEGG: eca:ECA0408 plasmid-related protein YP_001175219.1 PFAM: plasmid stabilization system; KEGG: eca:ECA0409 plasmid-related protein YP_001175220.1 KEGG: sbo:SBO_4358 hypothetical protein YP_001175221.1 PFAM: periplasmic pectate lyase; KEGG: eca:ECA2135 periplasmic pectate lyase YP_001175222.1 PFAM: Oligogalacturonate-specific porin; KEGG: yps:YPTB3835 KdgM family oligogalacturonate specific porin YP_001175223.1 PFAM: regulatory protein, LuxR YP_001175224.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001175225.1 PFAM: GCN5-related N-acetyltransferase; KEGG: mxa:MXAN_2615 acetyltransferase, GNAT family YP_001175226.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: eca:ECA2168 conserved hypothetical protein YP_001175227.1 PFAM: regulatory protein, DeoR; Helix-turn-helix, type 11 domain protein; KEGG: eca:ECA1907 DeoR-family transcriptional regulator YP_001175228.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001175230.1 PFAM: Cupin 4 family protein; SMART: transcription factor jumonji, jmjC domain protein; KEGG: eca:ECA0420 hypothetical protein YP_001175231.1 PFAM: helix-turn-helix- domain containing protein, AraC type; KEGG: sec:SC0404 transcription regulator, AraC family YP_001175232.1 TIGRFAM: TonB-dependent siderophore receptor; PFAM: TonB-dependent receptor; TonB-dependent receptor, plug; KEGG: stm:STM0364 ferrioxamine receptor YP_001175233.1 PFAM: regulatory protein GntR, HTH; aminotransferase, class I and II; KEGG: ecj:JW4303 fused predicted DNA-binding transcriptional regulator and predicted aminotransferase YP_001175234.1 PFAM: protein of unknown function DUF1127; KEGG: sdy:SDY_4602 hypothetical protein YP_001175235.1 KEGG: ftn:FTN_0318 hypothetical protein YP_001175236.1 PFAM: regulatory protein GntR, HTH; aminotransferase, class I and II; KEGG: hch:HCH_03332 transcriptional regulator containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs YP_001175237.1 TIGRFAM: alkylhydroperoxidase like protein, AhpD family; PFAM: Carboxymuconolactone decarboxylase; KEGG: bam:Bamb_5794 alkylhydroperoxidase like protein, AhpD family YP_001175238.1 PFAM: regulatory protein, ArsR; KEGG: sty:HCM1.244c transcriptional regulator YP_001175239.1 TIGRFAM: outer membrane autotransporter barrel domain; PFAM: Autotransporter beta- domain protein; KEGG: dps:DP2127 hypothetical protein YP_001175240.1 PFAM: regulatory protein, LuxR; KEGG: yen:YE1165 LuxR-family transcriptional regulatory protein YP_001175242.1 PFAM: regulatory protein, MarR; KEGG: sfr:Sfri_3252 transcriptional regulator, MarR family protein YP_001175243.1 PFAM: secretion protein HlyD family protein; KEGG: pae:PA3360 probable secretion protein YP_001175244.1 KEGG: vpa:VPA1217 hypothetical protein YP_001175245.1 PFAM: protein of unknown function DUF445; KEGG: sec:SC4371 inner membrane protein YP_001175246.1 PFAM: aldehyde dehydrogenase; KEGG: stm:STM4519 NAD-dependent aldehyde dehydrogenase YP_001175247.1 PFAM: cobalamin synthesis protein, P47K; cobalamin synthesis CobW domain protein; KEGG: stm:STM4530 cobalamin biosynthetic protein YP_001175248.1 PFAM: protein of unknown function DUF466; KEGG: sdy:SDY_4606 hypothetical protein YP_001175249.1 PFAM: carbon starvation protein CstA; KEGG: sdy:SDY_4607 carbon starvation protein YP_001175250.1 PFAM: regulatory protein, DeoR; KEGG: pna:Pnap_2746 helix-turn-helix, type 11 domain protein YP_001175251.1 PFAM: ligand binding Tar domain protein; histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; KEGG: ecs:ECs5315 methyl-accepting chemotaxis protein I YP_001175252.1 catalyzes the transfer of phosphoglycerol to the glucan backbone YP_001175253.1 KEGG: sbo:SBO_4420 glycoprotein/receptor YP_001175254.1 acts to load the DnaB helicase onto the initiation site during DNA replication YP_001175255.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' YP_001175256.1 PFAM: OsmC family protein; KEGG: aci:ACIAD3023 organic hydroperoxide resistance protein YP_001175257.1 PFAM: regulatory protein, MarR; KEGG: eca:ECA3168 transcriptional regulator of organic hydroperoxide resistance gene ohr YP_001175258.1 PFAM: regulatory protein, TetR; KEGG: pfo:Pfl_4904 transcriptional regulator, TetR family YP_001175259.1 KEGG: stm:STM4545 inner membrane protein YP_001175260.1 PFAM: protein of unknown function DUF1212; KEGG: stm:STM4546 hypothetical protein YP_001175261.1 PFAM: regulatory protein, LuxR; KEGG: spt:SPA4361 conserved hypothetical regulatory protein YP_001175262.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin YP_001175263.1 PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: stm:STM4549 cytoplasmic protein YP_001175264.1 TIGRFAM: PTS system, lactose/cellobiose family IIC subunit; PFAM: phosphotransferase system, EIIC; KEGG: eca:ECA4434 PTS system, IIbc component YP_001175265.1 PFAM: ferric iron reductase; KEGG: spt:SPA4364 ferric iron reductase YP_001175266.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: sec:SC4403 diguanylate cyclase/phosphodiesterase domain 1 YP_001175267.1 PFAM: protein of unknown function DUF1435; KEGG: sdy:SDY_4626 hypothetical protein YP_001175268.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit YP_001175269.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_001175270.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18 YP_001175271.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily YP_001175272.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_001175273.1 PFAM: transport-associated; SMART: Transport-associated and nodulation region, bacteria; KEGG: sfv:SFV_4410 hyperosmotically inducible periplasmic protein YP_001175274.1 PFAM: protein of unknown function DUF1328 YP_001175275.1 PFAM: Patatin; KEGG: stm:STM4563 phosphoesterase YP_001175276.1 PFAM: TatD-related deoxyribonuclease; KEGG: ecj:JW4341 predicted DNase YP_001175277.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Radical SAM domain protein; KEGG: sfv:SFV_4413 activating enzyme YP_001175278.1 KEGG: ecj:JW4343 conserved hypothetical protein YP_001175279.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_001175280.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate YP_001175281.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_001175282.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_001175283.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins YP_001175284.1 KEGG: sec:SC4421 membrane protein, transcribed divergently from SerB YP_001175285.1 catalyzes the formation of serine from O-phosphoserine YP_001175286.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001175287.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide YP_001175288.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: yen:YE0581 oxidoreductase YP_001175289.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: eca:ECA3903 LysR-family transcriptional activator YP_001175290.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_001175291.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan YP_001175292.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription YP_001175293.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog YP_001175294.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate YP_001175295.1 PFAM: helix-turn-helix- domain containing protein, AraC type; transcription activator, effector binding; KEGG: spt:SPA4396 right origin-binding protein YP_001175296.1 PFAM: CreA family protein; KEGG: stm:STM4587 periplasmic protein YP_001175297.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation YP_001175298.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation YP_001175299.1 PFAM: Inner membrane CreD family protein; KEGG: stm:STM4590 tolerance to colicin E2 YP_001175300.1 PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: stm:STM4598 response regulator (OmpR family) in two-component regulatory system with ArcB (or CpxA), regulates genes in aerobic pathways YP_001175301.1 member of the SPOUT superfamily of methyltransferases YP_001175302.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_001175303.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_001175304.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_001175306.1 PFAM: protein of unknown function DUF328; KEGG: sfx:S0006 hypothetical protein YP_001175307.1 TIGRFAM: amino acid carrier protein; PFAM: sodium:alanine symporter; KEGG: sec:SC0006 AGCS family, alanine/glycine transport protein YP_001175308.1 KEGG: sdy:SDY_0008 transaldolase B; TIGRFAM: transaldolase; PFAM: Transaldolase YP_001175309.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis YP_001175310.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: yen:YE0606 transport protein YP_001175311.1 KEGG: eca:ECA3241 ABC transporter, substrate binding protein YP_001175312.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: yen:YE1460 siderophore ABC transporter, ATP-binding subunit YP_001175313.1 PFAM: transport system permease; ABC-3 protein; KEGG: yps:YPTB1342 FecCD-family ABC transport permease YP_001175314.1 PFAM: Cl- channel, voltage-gated family protein; KEGG: bxe:Bxe_A2770 chloride channel protein, voltage gated YP_001175315.1 PFAM: GPR1/FUN34/yaaH family protein; KEGG: ssn:SSO_0011 hypothetical protein YP_001175316.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001175317.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001175318.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH YP_001175319.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC YP_001175320.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_001175321.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_001175322.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_001175323.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001175324.1 PFAM: peptidylprolyl isomerase, FKBP-type; KEGG: stm:STM0048 FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) YP_001175325.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_001175326.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: aci:ACIAD2742 transcriptional regulator YP_001175327.1 KEGG: pfl:PFL_1766 alanyl-tRNA synthetase-related protein YP_001175328.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001175329.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001175330.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_001175331.1 PFAM: MORN variant repeat protein; KEGG: hso:HS_1653 hypothetical protein YP_001175332.1 PFAM: protein of unknown function DUF903; KEGG: stm:STM0080 outer membrane lipoprotein YP_001175333.1 Required for full activity of KefC, a potassium-proton antiporter YP_001175334.1 transport system that facilitates potassium-efflux YP_001175335.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate YP_001175336.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_001175337.1 protein associated with Co2+ and Mg2+ efflux YP_001175338.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001175339.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_001175340.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB YP_001175341.1 determines N-hexane tolerance and is involved in outer membrane permeability YP_001175342.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system YP_001175343.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs YP_001175344.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA YP_001175345.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C YP_001175346.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_001175347.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism YP_001175348.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate YP_001175349.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose YP_001175350.1 KEGG: stm:STM0105 hypothetical protein YP_001175351.1 with TbpA and ThiP is part of the thiamine and TPP transport system YP_001175352.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine YP_001175353.1 part of the thiamine and TPP transport system tbpA-thiPQ YP_001175354.1 activates sgrS under glucose-phosphate stress conditions YP_001175355.1 KEGG: sec:SC0104 hypothetical protein YP_001175356.1 TIGRFAM: sugar efflux transporter; PFAM: major facilitator superfamily MFS_1; KEGG: sfx:S0067 transport protein YP_001175357.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_001175358.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_001175359.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_001175360.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_001175361.1 activator for leuABCD operon; member of LysR family of transcriptional activators YP_001175362.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive YP_001175363.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_001175364.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism YP_001175365.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_001175366.1 TIGRFAM: S-adenosyl-methyltransferase MraW; PFAM: methyltransferase; KEGG: sbo:SBO_0070 apolipoprotein YP_001175367.1 membrane bound cell division protein at septum containing leucine zipper motif YP_001175368.1 PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain; KEGG: stm:STM0122 division specific transpeptidase, penicillin-binding protein 3 re YP_001175369.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_001175370.1 TIGRFAM: UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein; KEGG: sbo:SBO_0074 D-alanine:D-alanine-adding enzyme YP_001175371.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001175372.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001175373.1 integral membrane protein involved in stabilizing FstZ ring during cell division YP_001175374.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001175375.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001175376.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001175377.1 involved in septum formation YP_001175378.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane YP_001175379.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001175380.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_001175381.1 secM translational pause allows for the initiation of secA translation YP_001175382.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_001175383.1 TIGRFAM: mutator MutT protein; PFAM: NUDIX hydrolase; KEGG: stm:STM0137 7,8-dihydro-8-oxoguanine-triphosphatase, prefers dGTP YP_001175384.1 PFAM: protein of unknown function DUF329; KEGG: sdy:SDY_0131 hypothetical protein YP_001175385.1 PFAM: protein of unknown function DUF1342; KEGG: stm:STM0139 hypothetical protein YP_001175386.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_001175387.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate YP_001175388.1 PFAM: type II secretion system protein; KEGG: ecp:ECP_0106 bacterial type II secretion system protein F YP_001175389.1 PFAM: type II secretion system protein E; KEGG: ecj:JW0103 conserved hypothetical protein with nucleoside triphosphate hydrolase domain YP_001175390.1 KEGG: ecj:JW0104 predicted major pilin subunit YP_001175391.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_001175392.1 PFAM: N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: sec:SC0145 N-acetyl-anhydromuramyl-L-alanine amidase YP_001175393.1 involved in regulation of beta-lactamase; signaling protein YP_001175394.1 PFAM: glycoside hydrolase, family 43; KEGG: sec:SC0147 cytoplasmic protein YP_001175395.1 TIGRFAM: sugar (Glycoside-Pentoside-Hexuronide) transporter; PFAM: major facilitator superfamily MFS_1; KEGG: stm:STM0149 Na+/galactoside symporter YP_001175396.1 PFAM: amino acid permease-associated region; KEGG: sdy:SDY_0142 aromatic amino acid transport protein YP_001175397.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex YP_001175398.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_001175399.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains YP_001175400.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001175401.1 KEGG: stm:STM0156 periplasmic protein YP_001175402.1 KEGG: stm:STM0157 outer membrane protein YP_001175403.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_001175404.1 PFAM: HNH endonuclease; KEGG: stm:STM0159 restriction endonuclease YP_001175405.1 PFAM: uncharacterised conserved protein UCP006287; KEGG: ecc:c0148 hypothetical protein YP_001175406.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine YP_001175407.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_001175408.1 KEGG: eci:UTI89_C0135 hypothetical protein YP_001175409.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification YP_001175410.1 PFAM: Pyrrolo-quinoline quinone; KEGG: stm:STM0169 glucose dehydrogenase YP_001175411.1 KEGG: sdy:SDY_0034 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase YP_001175412.1 catalyzes the interconversion of bicarbonate and carbon dioxide YP_001175413.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: sec:SC0172 ABC-type multidrug transport system, ATPase component YP_001175414.1 PFAM: ABC-2 type transporter; KEGG: stm:STM0173 ABC superfamily (membrane) transport protein YP_001175415.1 PFAM: PTS system fructose subfamily IIA component; KEGG: stt:t0179 IIA component of PTS system YP_001175416.1 PFAM: polysaccharide deacetylase; KEGG: ssn:SSO_0138 hypothetical protein YP_001175417.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_001175418.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_001175419.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_001175420.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP YP_001175421.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's YP_001175422.2 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu YP_001175423.1 TIGRFAM: RNA polymerase-binding protein DksA; PFAM: zinc finger, DksA/TraR C4-type; KEGG: stm:STM0186 dnaK suppressor protein YP_001175424.1 Regulatory factor involved in maltose metabolism YP_001175425.1 TIGRFAM: 2'-5' RNA ligase; PFAM: 2',5' RNA ligase; KEGG: ecv:APECO1_1838 2'-5' RNA ligase YP_001175426.1 similar in sequence to the ATP-dependent RNA helicase HrpA YP_001175427.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell YP_001175428.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein YP_001175429.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter YP_001175430.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores YP_001175431.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome YP_001175432.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_001175433.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation YP_001175434.1 TIGRFAM: iron-sulfur cluster assembly accessory protein; PFAM: HesB/YadR/YfhF-family protein; KEGG: yen:YE0736 hypothetical protein YP_001175435.1 PFAM: protein of unknown function UPF0126; KEGG: sbo:SBO_0146 hypothetical protein YP_001175436.1 solute binding component of the vitamin B12 transport system BtuCDF YP_001175437.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_001175438.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate YP_001175439.1 protease Do; required at high temperature; degrades damaged proteins YP_001175440.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization YP_001175441.1 KEGG: sdy:SDY_0181 structural protein YP_001175442.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_001175443.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_001175444.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_001175445.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001175446.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001175447.1 Catalyzes the phosphorylation of UMP to UDP YP_001175448.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001175449.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_001175450.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_001175451.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate YP_001175452.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response YP_001175453.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins YP_001175454.1 PFAM: outer membrane chaperone Skp (OmpH); KEGG: stm:STM0225 histone-like protein, located in outer membrane YP_001175455.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_001175456.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_001175457.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_001175458.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_001175459.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001175460.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_001175461.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_001175462.1 PFAM: Orn/Lys/Arg decarboxylase, major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: stm:STM0234 lysine decarboxylase 2 YP_001175463.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: eci:UTI89_C0202 lactoylglutathione lyase YP_001175464.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase YP_001175465.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination YP_001175466.1 PFAM: protein of unknown function UPF0253; KEGG: stm:STM0238 hypothetical protein YP_001175467.1 PFAM: YaeQ family protein; KEGG: stm:STM0239 cytoplasmic protein YP_001175468.1 PFAM: Class I peptide chain release factor; KEGG: stt:t0242 hypothetical protein YP_001175469.1 PFAM: copper resistance lipoprotein NlpE; KEGG: spt:SPA0248 copper homeostasis protein CutF precursor YP_001175470.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001175471.1 PFAM: protein of unknown function UPF0066; KEGG: stm:STM0243 regulatory protein YP_001175472.1 KEGG: stm:STM0244 regulator in colanic acid synthesis; overexpression confers mucoid phenotype, increases capsule synthesis YP_001175473.1 TIGRFAM: lipoprotein, YaeC family; PFAM: NLPA lipoprotein; KEGG: sbo:SBO_0186 lipoprotein YP_001175474.1 part of the MetNIQ methionine uptake system YP_001175475.1 part of the metNIQ transport system for methionine YP_001175476.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate YP_001175477.1 KEGG: spt:SPA2170 transposase YP_001175478.1 PFAM: Integrase, catalytic region; KEGG: sfv:SFV_0337 ISEhe3 orfB YP_001175479.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: sdy:SDY_0227 transcriptional regulator LysR-type YP_001175480.1 PFAM: Endonuclease/exonuclease/phosphatase; KEGG: sec:SC0254 hypothetical protein YP_001175481.1 PFAM: UbiE/COQ5 methyltransferase; methyltransferase small; Methyltransferase type 11; Methyltransferase type 12; KEGG: ecv:APECO1_1780 hypothetical protein YP_001175482.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall YP_001175483.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione YP_001175484.1 PFAM: Methyltransferase type 11; KEGG: ecv:APECO1_1777 S-adenosyl-L-methionine-dependent methyltransferase YP_001175485.1 PFAM: ribonuclease H; KEGG: stm:STM0263 RNase HI, degrades RNA of DNA-RNA hybrids YP_001175486.1 3'-5' exonuclease of DNA polymerase III YP_001175487.1 PFAM: regulatory protein GntR, HTH; GntR domain protein; KEGG: psb:Psyr_2675 regulatory protein, GntR:bacterial regulatory protein, GntR YP_001175488.1 KEGG: psb:Psyr_2676 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal; TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001175489.1 KEGG: psb:Psyr_2677 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal; TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001175490.1 PFAM: extracellular solute-binding protein, family 5; KEGG: psp:PSPPH_2786 ABC-transport protein, solute-binding component YP_001175491.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: psp:PSPPH_2785 ABC-transport protein, inner membrane component YP_001175492.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: psb:Psyr_2680 binding-protein-dependent transport systems inner membrane component YP_001175493.1 PFAM: gamma-glutamyltranspeptidase; KEGG: pol:Bpro_1819 gamma-glutamyltransferase YP_001175494.1 PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: ecj:JW5019 predicted C-N hydrolase family amidase, NAD(P)-binding YP_001175495.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA YP_001175496.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate YP_001175497.1 PFAM: glutamine amidotransferase, class-II; KEGG: sbo:SBO_0214 amidotransferase YP_001175498.1 PFAM: protein of unknown function DUF949; KEGG: stm:STM0312 periplasmic protein YP_001175499.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_001175500.1 KEGG: sec:SC0317 aminoacyl-histidine dipeptidase (peptidase D); TIGRFAM: aminoacyl-histidine dipeptidase; PFAM: peptidase M20; peptidase dimerisation domain protein YP_001175501.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively YP_001175502.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation YP_001175503.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS YP_001175504.1 PFAM: porin, Gram-negative type; KEGG: ecc:c0388 outer membrane pore protein E precursor YP_001175505.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_001175506.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_001175507.1 PFAM: phage integrase family protein; KEGG: sbo:SBO_0251 phage integrase YP_001175508.1 KEGG: stt:t1927 bacteriophage protein YP_001175509.1 TIGRFAM: phage N-6-adenine-methyltransferase; PFAM: DNA N-6-adenine-methyltransferase; KEGG: eci:UTI89_C5102 DNA adenine methylase YP_001175510.1 KEGG: sgl:SG0741 hypothetical protein YP_001175511.1 KEGG: bbr:BB3533 hypothetical protein YP_001175512.1 3'-5' exonuclease activity on single or double-strand DNA YP_001175514.1 KEGG: ecc:c1404 hypothetical protein YdfD YP_001175516.1 PFAM: helix-turn-helix domain protein; peptidase S24, S26A and S26B; KEGG: stm:STM0898 transcriptional regulator YP_001175517.1 KEGG: ecs:ECs1942 regulatory protein YP_001175518.1 KEGG: sec:SC2633 Gifsy-1 prophage CI protein YP_001175520.1 TIGRFAM: phage replication protein O; PFAM: phage replication protein O domain protein; KEGG: sec:SC0340 replication protein O YP_001175521.1 PFAM: DnaB domain protein helicase, N-terminal domain protein; DnaB domain protein helicase, C-terminal domain protein; KEGG: sfv:SFV_0273 replication protein P YP_001175524.1 PFAM: NinB family protein; KEGG: ecs:ECs2982 hypothetical protein YP_001175526.1 PFAM: endodeoxyribonuclease RusA; KEGG: bld:BLi01452 YqaN YP_001175528.1 KEGG: pde:Pden_0993 hypothetical protein YP_001175530.1 KEGG: gfo:orf3258 hypothetical protein YP_001175531.1 PFAM: glycoside hydrolase, family 24; KEGG: ypn:YPN_1570 phage lysozyme YP_001175532.1 KEGG: yps:YPTB1806 hypothetical protein YP_001175534.1 KEGG: ypn:YPN_1573 hypothetical protein YP_001175535.1 KEGG: ypn:YPN_1574 hypothetical protein YP_001175536.1 KEGG: sec:SC2610 hypothetical protein YP_001175537.1 KEGG: sty:STY1049 bacteriophage protein YP_001175538.1 KEGG: ssn:SSO_0738 bacteriophage protein YP_001175539.1 KEGG: ssn:SSO_0739 bacteriophage protein YP_001175540.1 KEGG: sdy:SDY_2116 bacteriophage protein YP_001175541.1 KEGG: sec:SC2600 bacteriophage protein YP_001175542.1 KEGG: stt:t1883 bacteriophage protein YP_001175543.1 KEGG: stt:t1882 bacteriophage protein YP_001175544.1 KEGG: sec:SC2597 bacteriophage protein YP_001175545.1 PFAM: Lytic transglycosylase, catalytic; KEGG: sty:STY1061 bacteriophage protein YP_001175546.1 KEGG: sty:STY1062 bacteriophage protein YP_001175547.1 KEGG: sty:STY1063 bacteriophage protein YP_001175548.1 KEGG: sty:STY1064 bacteriophage protein YP_001175549.1 KEGG: sty:STY1065 secreted protein YP_001175551.1 KEGG: sty:STY1068 bacteriophage protein YP_001175552.1 KEGG: stt:t1871 bacteriophage protein YP_001175553.1 KEGG: sec:SC2585 bacteriophage protein YP_001175554.1 KEGG: stt:t1869 bacteriophage protein YP_001175555.1 KEGG: sec:SC2582 Fels-2 prophage Pin YP_001175556.1 PFAM: phage tail assembly chaperone gp38; KEGG: stt:t3435 hypothetical protein YP_001175557.1 PFAM: alpha/beta hydrolase fold; KEGG: cvi:CV2920 probable hydrolase YP_001175559.1 TIGRFAM: amino acid/peptide transporter; PFAM: TGF-beta receptor, type I/II extracellular region; major facilitator superfamily MFS_1; KEGG: yen:YE1609 peptide transport protein YP_001175560.1 PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: aci:ACIAD0539 methyltransferase YP_001175561.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; histidine kinase, HAMP region domain protein; KEGG: nha:Nham_4588 diguanylate cyclase (GGDEF domain) YP_001175562.1 PFAM: protein of unknown function UPF0118; KEGG: eca:ECA0120 hypothetical protein YP_001175563.1 PFAM: amino acid permease-associated region; KEGG: ecj:JW5027 predicted S-methylmethionine transporter YP_001175564.1 converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines YP_001175565.1 PFAM: protein of unknown function DUF796; KEGG: sgl:SG0148 hypothetical protein YP_001175566.1 Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import YP_001175567.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ecs:ECs0414 ferric transport system permease YP_001175568.1 PFAM: extracellular solute-binding protein, family 1; KEGG: ecs:ECs0415 periplasmic-iron-binding protein YP_001175569.1 PFAM: protein of unknown function DUF1228; major facilitator superfamily MFS_1; KEGG: ecs:ECs0416 regulatory protein YP_001175570.1 PFAM: ATP-binding region, ATPase domain protein domain protein; MASE1 domain protein; histidine kinase, dimerisation and phosphoacceptor region; KEGG: ecs:ECs0417 sensor histidine protein kinase YP_001175571.1 PFAM: regulatory protein, LuxR; response regulator receiver; Sigma-70, region 4 type 2; KEGG: sdy:SDY_0506 response regulator YP_001175572.1 PFAM: Integrase, catalytic region; KEGG: rpe:RPE_1052 integrase, catalytic region YP_001175573.1 with TauB and TauC is responsible for taurine uptake. YP_001175574.1 Part of the ABC transporter complex tauABC involved in taurine import YP_001175575.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ecs:ECs0421 taurine transport system permease YP_001175576.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers YP_001175577.1 PFAM: phospholipid/glycerol acyltransferase; KEGG: eca:ECA4119 acyltransferase YP_001175578.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001175579.1 this protein has no known enzymatic function YP_001175580.1 PFAM: isochorismatase hydrolase; KEGG: eca:ECA1767 isochorismatase family protein YP_001175581.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope YP_001175582.1 PFAM: protein of unknown function DUF1615; KEGG: ecj:JW0369 predicted DNA-binding transcriptional regulator YP_001175583.1 KEGG: stm:STM0378 inner membrane protein YP_001175584.1 KEGG: sdy:SDY_0366 hypothetical protein YP_001175585.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001175586.1 PFAM: Extensin family protein; KEGG: stt:t2483 hypothetical protein YP_001175587.1 PFAM: major facilitator superfamily MFS_1; KEGG: stm:STM0382 permease YP_001175588.1 KEGG: stm:STM0383 cytoplasmic protein YP_001175589.1 PFAM: Alkaline phosphatase; KEGG: sbo:SBO_0278 alkaline phosphatase YP_001175590.1 PFAM: PsiF repeat protein; KEGG: sbo:SBO_0279 PsiF YP_001175591.1 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis YP_001175592.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_001175593.1 PFAM: protein of unknown function DUF188; KEGG: sdy:SDY_0357 hypothetical protein YP_001175594.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_001175595.1 KEGG: sec:SC0430 cytoplasmic protein YP_001175596.1 PFAM: AroM family protein; KEGG: stm:STM0390 aro operon protein YP_001175597.1 PFAM: protein of unknown function DUF1255; KEGG: spt:SPA2332 hypothetical protein YP_001175598.1 Required for efficient pilin antigenic variation YP_001175599.1 catalyzes phosphorylation of fructose; cytosolic enzyme YP_001175600.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity YP_001175601.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity YP_001175602.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB YP_001175603.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB YP_001175604.1 PFAM: branched-chain amino acid transport system II carrier protein; KEGG: stm:STM0399 LIVCS family, branched chain amino acid transporter system II (LIV-II) YP_001175605.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation YP_001175606.1 PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain; KEGG: ecj:JW0393 maltodextrin glucosidase YP_001175607.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein; KEGG: stm:STM0402 thiol - alkyl hydroperoxide reductase YP_001175608.1 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP YP_001175609.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_001175610.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_001175611.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_001175612.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_001175613.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001175614.1 PFAM: nucleoside-specific channel-forming protein, Tsx; KEGG: ecv:APECO1_1599 nucleoside-specific channel-forming protein Tsx YP_001175615.1 KEGG: ecj:JW5056 predicted lipoprotein YP_001175616.1 PFAM: ATP-cone domain protein; KEGG: stm:STM0415 transcriptional regulator YP_001175617.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil YP_001175618.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_001175619.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_001175620.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP YP_001175621.1 PFAM: aldo/keto reductase; KEGG: ecj:JW0409 predicted oxidoreductase, NAD(P)-binding YP_001175622.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001175623.1 PFAM: Polyprenyl synthetase; KEGG: stm:STM0423 geranyltranstransferase YP_001175624.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_001175625.1 Required for the synthesis of the thiazole moiety YP_001175626.1 TIGRFAM: DJ-1 family protein; PFAM: ThiJ/PfpI domain protein; KEGG: sec:SC0474 4-methyl-5(beta-hydroxyethyl)-thiazole synthesis YP_001175627.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_001175628.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_001175629.1 PFAM: major facilitator superfamily MFS_1; KEGG: stt:t2427 hypothetical major facilitator family transport protein YP_001175630.1 converts protoheme IX and farnesyl diphosphate to heme O YP_001175631.1 PFAM: cytochrome C oxidase subunit IV; KEGG: sbo:SBO_0323 cytochrome o ubiquinol oxidase subunit IV YP_001175632.1 PFAM: cytochrome c oxidase, subunit III; KEGG: ssn:SSO_0413 cytochrome o ubiquinol oxidase subunit III YP_001175633.1 PFAM: cytochrome c oxidase, subunit I; KEGG: ssn:SSO_0414 cytochrome o ubiquinol oxidase subunit I YP_001175634.1 TIGRFAM: ubiquinol oxidase, subunit II; PFAM: cytochrome c oxidase, subunit II; COX aromatic rich domain protein; KEGG: ecc:c0543 ubiquinol oxidase polypeptide II precursor YP_001175635.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein YP_001175636.1 PFAM: Uncharacterized lipoprotein; KEGG: sec:SC0487 lipoprotein YP_001175637.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress YP_001175638.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001175639.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001175640.1 binds and unfolds substrates as part of the ClpXP protease YP_001175641.1 KEGG: ssn:SSO_0422 DNA-binding, ATP-dependent protease La; TIGRFAM: ATP-dependent protease La; PFAM: peptidase S16, lon domain protein; AAA ATPase, central domain protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001175642.1 histone-like DNA-binding protein YP_001175643.1 PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase; KEGG: sbo:SBO_0335 protease maturation protein YP_001175644.1 TIGRFAM: competence protein ComEA helix-hairpin-helix repeat protein; KEGG: sdy:SDY_0290 hypothetical protein YP_001175645.1 PFAM: thioesterase superfamily protein; KEGG: stm:STM0454 esterase YP_001175646.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His YP_001175647.1 PFAM: extracellular solute-binding protein, family 5; KEGG: spt:SPA2266 solute-binding protein YP_001175648.1 TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase, type 3; KEGG: stt:t2403 conserved hypothetical protein YP_001175649.1 PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: sec:SC0500 cysteine synthase/cystathionine beta-synthase YP_001175650.1 PFAM: regulatory protein, AsnC/Lrp family; KEGG: stm:STM0459 transcriptional regulator (AsnC familiy) YP_001175651.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase; KEGG: sfv:SFV_0422 ATP-binding component of a transport system YP_001175652.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase; KEGG: sbo:SBO_0344 ATP-binding component of a transport system YP_001175653.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia. YP_001175654.1 TIGRFAM: ammonium transporter; PFAM: Rh family protein/ammonium transporter; KEGG: ssn:SSO_0439 probable ammonium transporter YP_001175655.1 KEGG: ssn:SSO_0440 acyl-CoA thioesterase II; TIGRFAM: acyl-CoA thioesterase II; PFAM: acyl-CoA thioesterase YP_001175656.1 KEGG: sfv:SFV_0427 glycoprotein/polysaccharide metabolism YP_001175657.1 PFAM: methylated-DNA-[protein]-cysteine S-methyltransferase; KEGG: stm:STM0466 methyltransferase YP_001175658.1 PFAM: GCN5-related N-acetyltransferase; KEGG: rru:Rru_A1580 GCN5-related N-acetyltransferase YP_001175660.1 PFAM: regulatory protein GntR, HTH; aminotransferase, class I and II; Helix-turn-helix, type 11 domain protein; KEGG: rha:RHA1_ro05556 transcriptional regulator/aminotransferase YP_001175661.1 PFAM: protein of unknown function DUF161; KEGG: sma:SAV6929 hypothetical protein YP_001175662.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer YP_001175663.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon YP_001175664.1 PFAM: protein of unknown function DUF1428; KEGG: sdy:SDY_0392 hypothetical protein YP_001175665.1 PFAM: EAL domain protein; KEGG: stm:STM0468 hypothetical protein YP_001175666.1 PFAM: regulatory protein GntR, HTH; UbiC transcription regulator-associated domain protein; KEGG: eca:ECA0190 GntR-family transcriptional regulator YP_001175667.1 PFAM: Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein; Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein; KEGG: eca:ECA0189 mandelate racemase / muconate lactonizing enzyme YP_001175668.1 PFAM: phosphotransferase system PTS, EIIB protein; phosphotransferase system, EIIC; KEGG: eca:ECA0188 PTS system, IIABC component YP_001175669.2 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001175670.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif YP_001175671.1 KEGG: bam:Bamb_3951 GCN5-related N-acetyltransferase YP_001175672.1 PFAM: regulatory protein GntR, HTH; aminotransferase, class I and II; KEGG: bbr:BB2428 GntR-family transcriptional regulator YP_001175673.1 KEGG: sec:SC0513 inner membrane protein YP_001175674.1 PFAM: transferase hexapeptide repeat containing protein; KEGG: sec:SC0514 maltose O-acetyltransferase YP_001175675.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins YP_001175676.1 KEGG: stm:STM0474 cytoplasmic protein YP_001175677.1 TIGRFAM: transporter, hydrophobe/amphiphile efflux-1 (HAE1) family; PFAM: acriflavin resistance protein; KEGG: stm:STM0475 RND family, acridine efflux pump YP_001175678.1 TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; KEGG: ecv:APECO1_1551 acriflavine resistance protein A precursor YP_001175679.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine YP_001175680.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS YP_001175681.1 KEGG: sec:SC0521 inner membrane protein YP_001175682.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks YP_001175683.1 PFAM: protein of unknown function DUF454; KEGG: stm:STM0482 hypothetical protein YP_001175684.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_001175685.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_001175686.1 PFAM: conserved hypothetical protein 103; KEGG: sdy:SDY_0448 hypothetical protein YP_001175687.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001175688.1 molecular chaperone YP_001175689.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_001175690.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_001175691.1 PFAM: PfkB domain protein; KEGG: sbo:SBO_0377 inosine-guanosine kinase YP_001175692.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein YP_001175693.1 PFAM: major facilitator superfamily MFS_1; KEGG: ecv:APECO1_1536 fosmidomycin resistance protein YP_001175694.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides YP_001175695.1 TIGRFAM: ybaK/ebsC protein; PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: sfv:SFV_0454 hypothetical protein YP_001175696.1 PFAM: GumN family protein; KEGG: ecv:APECO1_1531 ligase YP_001175697.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; copper-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; Heavy metal transport/detoxification protein; E1-E2 ATPase-associated domain protein; KEGG: stm:STM0498 copper-transporting ATPase YP_001175698.1 activator of copper-responsive regulon genes YP_001175699.1 PFAM: protein of unknown function DUF107; KEGG: stm:STM0500 hypothetical protein YP_001175700.1 PFAM: band 7 protein; KEGG: stm:STM0501 inner membrane protein YP_001175701.1 PFAM: Thioredoxin domain; KEGG: stt:t2356 thioredoxin-like protein YP_001175702.1 PFAM: short-chain dehydrogenase/reductase SDR; KR; KEGG: sbo:SBO_0395 oxidoreductase YP_001175703.1 PFAM: lipolytic enzyme, G-D-S-L family; KEGG: ecv:APECO1_1515 multifunctional acyl-CoA thioesterase I and protease I and lysophospholipase L1 YP_001175704.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: stm:STM0507 ABC superfamily (atp_bind) transporter YP_001175705.1 PFAM: protein of unknown function DUF214; KEGG: ecp:ECP_0563 membrane protein YbbP YP_001175706.1 KEGG: stm:STM0509 outer membrane protein YP_001175707.1 PFAM: NLPA lipoprotein; KEGG: stm:STM0510 ABC-type transport system ATPase component/cell division protein YP_001175708.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: sec:SC0552 ABC-type transport system ATPase component/cell division protein YP_001175709.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: stm:STM0512 binding-protein-dependent transport systems inner membrane component YP_001175710.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA YP_001175711.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_001175712.1 KEGG: ecv:APECO1_1492 phosphoribosylaminoimidazole carboxylase catalytic subunit; TIGRFAM: phosphoribosylaminoimidazole carboxylase, catalytic subunit; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase YP_001175713.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine YP_001175714.1 PFAM: peptidyl-prolyl cis-trans isomerase, cyclophilin type; KEGG: stm:STM0536 peptidyl-prolyl cis-trans isomerase B (rotamase B) YP_001175715.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001175717.1 PFAM: peptidylprolyl isomerase, FKBP-type; KEGG: lma:LmjF16.1460 kinesin YP_001175718.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: vfi:VF1720 maltose regulon regulatory protein MalI YP_001175719.1 TIGRFAM: PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS, EIIB protein; phosphotransferase system, EIIC; KEGG: gka:GK0991 PTS system, glucose-specific enzyme II, A component YP_001175720.1 KEGG: stm:STM0541 cytoplasmic protein YP_001175721.1 PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; KEGG: ecj:JW0518 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase and 5,10-methylene-tetrahydrofolate cyclohydrolase YP_001175722.1 PFAM: Fimbrial protein; KEGG: spt:SPA2182 type-1 fimbrial protein, a chain precursor YP_001175723.1 PFAM: Fimbrial protein; KEGG: stm:STM0544 fimbrial protein internal segment YP_001175724.1 PFAM: pili assembly chaperone; KEGG: stm:STM0545 periplasmic chaperone, required for type 1 fimbriae YP_001175725.1 PFAM: fimbrial biogenesis outer membrane usher protein; KEGG: stm:STM0546 outer membrane usher protein YP_001175726.1 KEGG: sec:SC0586 minor fimbrial subunit YP_001175727.1 PFAM: Fimbrial protein; KEGG: stm:STM0548 fimbrial protein YP_001175728.1 activates the production of the major fimbrae protein FimA YP_001175729.1 PFAM: regulatory protein, LuxR; KEGG: stm:STM0550 regulatory protein YP_001175730.1 PFAM: EAL domain protein; KEGG: fra:Francci3_2421 diguanylate phosphodiesterase (EAL domain) with GAF sensor YP_001175731.1 PFAM: phage integrase family protein; KEGG: ecj:JW0525 predicted integrase YP_001175732.1 KEGG: atc:AGR_pTi_207 hypothetical protein YP_001175733.1 KEGG: eci:UTI89_C2668 hypothetical protein YP_001175734.1 KEGG: ppu:PP_3911 hypothetical protein YP_001175735.1 KEGG: ecs:ECs3005 hypothetical protein YP_001175736.1 KEGG: plu:plu2936 hypothetical protein YP_001175737.1 PFAM: RecT protein; KEGG: plu:plu2935 hypothetical protein YP_001175743.1 KEGG: sec:SC0970 hypothetical protein YP_001175745.1 PFAM: peptidase S24, S26A and S26B; KEGG: eca:ECA2435 regulator of pectin lyase production YP_001175746.1 KEGG: ppu:PP_3034 regulator protein YP_001175747.1 PFAM: bacteriophage CII family protein; KEGG: ecv:APECO1_4184 hypothetical protein YP_001175748.1 PFAM: phage replication protein O domain protein; KEGG: ecp:ECP_1149 replication protein O YP_001175749.1 PFAM: replication P family protein; KEGG: ecp:ECP_1150 replication protein 14 YP_001175750.1 KEGG: eci:UTI89_C2689 hypothetical protein YP_001175751.1 KEGG: ecs:ECs1169 hypothetical protein YP_001175752.1 KEGG: stt:t1914 methyltransferase YP_001175753.1 PFAM: HNH endonuclease; SMART: HNH nuclease; KEGG: stm:PSLT094.1N hypothetical protein YP_001175754.1 KEGG: spt:SPA2428 hypothetical protein YP_001175756.1 DLP12 prophage YP_001175757.1 PFAM: bacteriophage Lambda NinG family protein; KEGG: hit:NTHI1505 hypothetical protein YP_001175758.1 KEGG: ecv:APECO1_4194 antitermination protein YP_001175760.1 PFAM: protein of unknown function DUF847; KEGG: spt:SPA1608 hypothetical protein YP_001175762.1 KEGG: sfx:S0700 bacteriophage protein YP_001175763.1 KEGG: ypn:YPN_MT0025 hypothetical protein YP_001175766.1 PFAM: NUDIX hydrolase; KEGG: ehi:27.t00041 actin, Pfam: TolA Actin PROSITE: GLU_RICH GLY_RICH LYS_RICH YP_001175767.1 KEGG: mca:MCA2673 hypothetical protein YP_001175773.1 KEGG: bta:789503 similar to mucin 5 YP_001175776.1 KEGG: sgl:SG0758 hypothetical protein YP_001175782.1 KEGG: ccr:CC0199 hypothetical protein YP_001175784.1 KEGG: ece:Z0314 unknown protein from prophage CP-933H YP_001175785.1 PFAM: phage tail assembly chaperone gp38; KEGG: plu:plu3023 hypothetical protein YP_001175786.1 PFAM: lipolytic enzyme, G-D-S-L family; KEGG: vvu:VV1_1768 lysophospholipase L1 YP_001175787.1 KEGG: sgl:SG2363 hypothetical protein YP_001175788.1 KEGG: stm:STM2230.1c DNA polymerase V subunit YP_001175789.1 PFAM: protein of unknown function DUF1471; KEGG: ecs:ECs0383 hypothetical protein YP_001175790.1 KEGG: stm:STM1586 periplasmic protein YP_001175791.1 TIGRFAM: TonB-dependent siderophore receptor; PFAM: TonB-dependent receptor; TonB-dependent receptor, plug; KEGG: ypn:YPN_2370 ferrichrome receptor protein YP_001175792.1 PFAM: amino acid permease-associated region; KEGG: stm:STM0568 APC family, phenylalanene transporter YP_001175793.1 PFAM: nucleoside:H+ symporter; major facilitator superfamily MFS_1; KEGG: eca:ECA1400 nucleoside H+ symporter YP_001175794.1 PFAM: AP endonuclease 2 domain protein; Xylose isomerase domain protein TIM barrel; KEGG: eca:ECA1399 hypothetical protein YP_001175795.1 PFAM: Semialdehyde dehydrogenase, NAD - binding; oxidoreductase domain protein; Oxidoreductase, C-terminal domain; homoserine dehydrogenase, NAD-binding; KEGG: eca:ECA1398 oxidoreductase YP_001175796.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: eca:ECA1397 LacI-family transcriptional regulator YP_001175797.1 PFAM: MscS Mechanosensitive ion channel; KEGG: ssn:SSO_0528 transport YP_001175798.1 PFAM: major facilitator superfamily MFS_1; KEGG: pae:PA1262 probable major facilitator superfamily (MFS) transporter YP_001175799.1 SMART: helix-turn-helix domain protein; KEGG: pau:PA14_47890 hypothetical protein YP_001175800.1 KEGG: stm:STM0374 inner membrane protein YP_001175801.1 PFAM: Fimbrial protein; KEGG: ecv:APECO1_2111 P pilus assembly protein, pilin FimA YP_001175802.1 KEGG: stm:STM0022 fimbrial chaparone YP_001175803.1 PFAM: fimbrial biogenesis outer membrane usher protein; KEGG: stm:STM0023 fimbrial usher YP_001175804.1 PFAM: Fimbrial protein; KEGG: plu:plu2156 hypothetical protein YP_001175805.1 KEGG: yen:YE1029 integral membrane protein YP_001175806.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive YP_001175807.1 PFAM: protein of unknown function DUF419; KEGG: stm:STM0579 cytoplasmic protein YP_001175808.1 PFAM: regulatory protein, TetR; KEGG: stm:STM0580 regulatory protein YP_001175809.1 PFAM: beta-lactamase domain protein; KEGG: xfa:XF1739 outer membrane protein YP_001175810.1 PFAM: helix-turn-helix- domain containing protein, AraC type; KEGG: spt:SPA2153 transcriptional activator RamA YP_001175811.1 TIGRFAM: TonB-dependent siderophore receptor; PFAM: TonB-dependent receptor; TonB-dependent receptor, plug; KEGG: stm:STM0191 outer membrane protein receptor / transporter for ferrichrome, colicin M, and phages T1, T5, and phi80 YP_001175812.1 PFAM: esterase; KEGG: plu:plu4257 enterochelin esterase and related enzymes YP_001175813.1 PFAM: protein of unknown function DUF1158; KEGG: stm:STM0582 inner membrane protein YP_001175814.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: cation transporting ATPase domain protein domain protein; Haloacid dehalogenase domain protein hydrolase; cation transporting ATPase domain protein; E1-E2 ATPase-associated domain protein; KEGG: yps:YPTB0594 Ca++ transporting P-type ATPase YP_001175815.1 TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; KEGG: yps:YPTB3307 HlyD family drug efflux protein YP_001175816.1 TIGRFAM: transporter, hydrophobe/amphiphile efflux-1 (HAE1) family; PFAM: acriflavin resistance protein; KEGG: ypn:YPN_3231 integral membrane efflux protein YP_001175817.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity YP_001175818.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: stt:t2813 possible LysR-family transcriptional regulator YP_001175819.1 PFAM: major facilitator superfamily MFS_1; KEGG: bur:Bcep18194_B2139 major facilitator superfamily (MFS_1) transporter YP_001175820.1 KEGG: stm:STM2910 cytoplasmic protein YP_001175821.1 PFAM: EAL domain protein; KEGG: sfx:S1241 hypothetical protein YP_001175822.1 PFAM: MltA-interacting MipA family protein; KEGG: stm:STM1286 scaffolding protein for murein-synthesizing holoenzyme YP_001175823.1 PFAM: major facilitator superfamily MFS_1; KEGG: gbe:GbCGDNIH1_1331 transporter, MFS superfamily YP_001175824.1 PFAM: protein of unknown function DUF606; KEGG: pcr:Pcryo_1329 protein of unknown function DUF606 YP_001175825.1 PFAM: protein of unknown function DUF606; KEGG: pcr:Pcryo_1328 protein of unknown function DUF606 YP_001175826.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: par:Psyc_0050 probable transcriptional regulator, LysR family YP_001175827.1 KEGG: eca:ECA1578 hypothetical protein YP_001175828.1 PFAM: pseudouridine synthase; KEGG: aha:AHA_1465 ribosomal large subunit pseudouridine synthase A YP_001175829.1 PFAM: Cold-shock protein, DNA-binding; KEGG: eca:ECA1580 cold-shock protein YP_001175830.1 KEGG: sbo:SBO_1138 hypothetical protein YP_001175831.1 PFAM: TonB-dependent receptor; TonB-dependent receptor, plug; KEGG: plu:plu2850 unnamed protein product; similar to outer membrane protein precursor YP_001175832.1 KEGG: ssn:SSO_1681 receptor YP_001175833.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: ecp:ECP_4314 ABC transporter ATP-binding protein YP_001175834.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: ecv:APECO1_2376 ABC transporter transporter, ATP-binding protein YP_001175835.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ecv:APECO1_2375 ABC transporter permease YddQ YP_001175836.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ecp:ECP_4317 transporter, permease YP_001175837.1 PFAM: extracellular solute-binding protein, family 5; KEGG: ecp:ECP_4318 dipeptide binding periplasmic protein YP_001175838.1 PFAM: GCN5-related N-acetyltransferase; KEGG: bxe:Bxe_B0245 acetyltransferase, GnaT family YP_001175839.1 PFAM: Sel1 domain protein repeat-containing protein; KEGG: mgm:Mmc1_2003 Sel1 domain protein repeat-containing protein YP_001175840.1 PFAM: regulatory protein GntR, HTH; aminotransferase, class I and II; KEGG: shw:Sputw3181_0946 transcriptional regulator, GntR family YP_001175841.1 PFAM: GCN5-related N-acetyltransferase; KEGG: eca:ECA3692 probable acetyltransferase YP_001175842.1 PFAM: protein of unknown function DUF1706; KEGG: eci:UTI89_P066 hypothetical protein YP_001175843.1 PFAM: periplasmic solute binding protein; KEGG: ecv:APECO1_274 ABC Mn+2/Fe+2 transporter, periplasmic substrate-binding protein YP_001175844.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: ecv:APECO1_273 ABC Mn+2/Fe+2 transporter, ATPase subunit SitB YP_001175845.1 PFAM: transport system permease; ABC-3 protein; KEGG: ecp:ECP_1190 iron transport protein, inner membrane component YP_001175846.1 PFAM: ABC-3 protein; KEGG: ecv:APECO1_271 ABC Mn+2/Fe+2 transporter, inner membrane subunit SitD YP_001175847.1 PFAM: 4'-phosphopantetheinyl transferase; KEGG: spt:SPA2150 enterobactin synthetase component D YP_001175848.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space YP_001175849.1 PFAM: esterase; KEGG: ecp:ECP_0616 ferric enterobactin esterase YP_001175850.1 PFAM: MbtH domain protein; KEGG: stm:STM0587 cytoplasmic protein YP_001175851.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin YP_001175852.1 with FepBDE is involved in the transport of ferric enterobactin YP_001175853.1 with FepBCD is involved in the transport of ferric enterobactin YP_001175854.1 with FepBCG is involved in the transport of ferric enterobactin YP_001175855.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters YP_001175856.1 with FepCDG is involved in the transport of ferric enterobactin YP_001175857.1 TIGRFAM: isochorismate synthase; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: ecv:APECO1_1456 isochorismate synthase YP_001175858.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate YP_001175859.1 PFAM: isochorismatase hydrolase; phosphopantetheine-binding; KEGG: stm:STM0597 2,3-dihydro-2,3-dihydroxybenzoate synthetase, isochorismatase YP_001175860.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin YP_001175861.1 PFAM: thioesterase superfamily protein; KEGG: sdy:SDY_0528 hypothetical protein YP_001175862.1 PFAM: carbon starvation protein CstA; KEGG: ecv:APECO1_1451 carbon starvation protein YP_001175863.1 PFAM: protein of unknown function DUF466; KEGG: stm:STM0601 cytoplasmic protein YP_001175864.1 PFAM: helix-turn-helix domain protein; KEGG: hso:HS_0535 possible transcriptional regulator YP_001175865.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR; KEGG: bam:Bamb_2430 short-chain dehydrogenase/reductase SDR YP_001175866.1 member of the iron-containing alcohol dehydrogenase family; unknown function YP_001175867.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: eca:ECA2719 ABC transporter, ATP-binding protein YP_001175868.1 PFAM: inner-membrane translocator; KEGG: eca:ECA2720 ABC transporter, permease YP_001175869.1 KEGG: eca:ECA1405 exported protein YP_001175870.1 KEGG: eca:ECA1404 hypothetical protein YP_001175871.1 phosphorylates methylthioribose to form methylthioribose-1-phosphate; involved in methionine salvage pathway YP_001175872.1 KEGG: eca:ECA3477 methylthioribose-1-phosphate isomerase; TIGRFAM: eIF-2B alpha/beta/delta-related uncharacterized protein; PFAM: initiation factor 2B related YP_001175873.1 PFAM: Acireductone dioxygenase, ARD; KEGG: sgl:SG0273 dioxygenase YP_001175874.1 TIGRFAM: 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: yps:YPTB0875 enolase-phosphatase E-1 YP_001175875.1 catalyzes the formation of diketo methylthiopentyl phosphate from methylribulose phosphate in the methionine salvage pathway YP_001175876.1 catalyzes the transfer of an amino moiety YP_001175877.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate YP_001175878.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: stm:STM0609 alkyl hydroperoxide reductase, F52a subunit; detoxification of hydroperoxides YP_001175879.1 PFAM: UspA domain protein; KEGG: stm:STM0614 universal stress protein YP_001175880.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation YP_001175881.1 PFAM: alpha/beta hydrolase fold; KEGG: bxe:Bxe_B1809 non-heme chloroperoxidase YP_001175882.1 KEGG: shw:Sputw3181_0586 conserved hypothetical flavoprotein oxygenase YP_001175883.1 PFAM: ribonuclease T2; KEGG: sfx:S0535 RNase I YP_001175884.1 responsible for the transport of C4-dicarboxylates during anaerobic growth YP_001175885.1 KEGG: eca:ECA1387 hypothetical protein YP_001175886.1 KEGG: eca:ECA1386 copper efflux system periplasmic protein CusF YP_001175887.1 KEGG: eca:ECA1385 hypothetical protein YP_001175888.1 TIGRFAM: efflux transporter, RND family, MFP subunit; KEGG: eca:ECA1384 copper efflux system protein YP_001175889.1 TIGRFAM: heavy metal efflux pump, CzcA family; PFAM: acriflavin resistance protein; KEGG: eca:ECA1383 cation efflux system protein YP_001175890.1 catalyzes the transfer of palmitate to lipid A YP_001175891.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator YP_001175892.1 TIGRFAM: CrcB protein; PFAM: Camphor resistance CrcB protein; KEGG: stm:STM0630 high-copy crc-csp restores normal chromosome condensation in presence of camphor or mukB mutations YP_001175893.1 PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: ecs:ECs0664 amidase YP_001175894.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_001175895.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001175896.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: stm:STM0634 transcriptional regulator YP_001175897.1 lipoyl-[acyl-carrier protein]-protein-N-lipoyltransferse; lipoate-protein ligase B; transfers lipoate to apolipoproteins; involved in lipoate metabolism YP_001175898.1 PFAM: protein of unknown function DUF493; KEGG: stm:STM0636 hypothetical protein YP_001175899.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors YP_001175900.1 TIGRFAM: rare lipoprotein A; PFAM: Rare lipoprotein A; Sporulation domain protein; KEGG: spt:SPA2096 rare lipoprotein A precursor YP_001175901.1 TIGRFAM: rod shape-determining protein RodA; PFAM: cell cycle protein; KEGG: stm:STM0639 rod shape-determining membrane protein; cell elongation in e phase YP_001175902.1 PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain; KEGG: stm:STM0640 cell elongation specific transpeptidase of penicillin-binding protein 2 (peptidoglycan synthetase) YP_001175903.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_001175904.1 TIGRFAM: iojap-like protein; PFAM: Iojap-related protein; KEGG: ecp:ECP_0667 hypothetical protein YP_001175905.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_001175906.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_001175907.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane YP_001175908.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001175909.1 PFAM: protein of unknown function DUF1451; KEGG: stm:STM0653 cytoplasmic protein YP_001175910.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific YP_001175911.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: stm:STM0662 ABC superfamily (atp_bind), glutamate/aspartate transporter YP_001175912.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: sec:SC0691 ABC superfamily (membrane), glutamate/aspartate transporter YP_001175913.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: stm:STM0664 ABC superfamily (membrane), glutamate/aspartate transporter YP_001175914.1 PFAM: extracellular solute-binding protein, family 3; KEGG: stm:STM0665 ABC superfamily (bind_prot), glutamate/aspartate transporter YP_001175915.1 Transfers the fatty acyl group on membrane lipoproteins YP_001175916.1 PFAM: CBS domain containing protein; transporter-associated region; KEGG: sdy:SDY_0594 transport protein YP_001175917.1 PFAM: protein of unknown function UPF0054; KEGG: sec:SC0696 metal-dependent hydrolase YP_001175918.1 PFAM: PhoH family protein; KEGG: sdy:SDY_0596 ATP-binding protein in pho regulon YP_001175919.1 KEGG: ecv:APECO1_1402 isopentenyl-adenosine A37 tRNA methylthiolase; TIGRFAM: RNA modification enzyme, MiaB family; tRNA-i(6)A37 thiotransferase enzyme MiaB; PFAM: deoxyribonuclease/rho motif-related TRAM; Radical SAM domain protein; Protein of unknown function UPF0004-like; SMART: Elongator protein 3/MiaB/NifB YP_001175920.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q YP_001175921.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP YP_001175922.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: stm:STM0681 phosphatase in N-acetylglucosamine metabolism YP_001175923.1 PFAM: ROK family protein; KEGG: spt:SPA2059 N-acetylglucosamine repressor YP_001175924.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate YP_001175925.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate YP_001175926.1 TIGRFAM: PTS system, glucose subfamily, IIA subunit; PTS system, N-acetylglucosamine-specific IIBC subunit; PTS system, glucose-like IIB subunint; PFAM: sugar-specific permease, EIIA 1 domain; phosphotransferase system PTS, EIIB protein; phosphotransferase system, EIIC; KEGG: yps:YPTB1120 PTS system, N-acetylglucosamine-specific IIABC component YP_001175927.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001175928.1 PFAM: outer membrane porin; KEGG: ecv:APECO1_1383 hypothetical protein YP_001175929.1 KEGG: ecv:APECO1_1382 conserved hypothetical lipoprotein YbfN precursor YP_001175930.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer YP_001175931.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001175932.1 PFAM: CopG domain protein DNA-binding domain protein; KEGG: stm:STM0695 SOS response protein YP_001175933.1 PFAM: alpha/beta hydrolase fold; PGAP1 family protein; KEGG: spt:SPA2045 esterase/lipase YbfF YP_001175934.1 negative modulator of the initiation of chromosome replication YP_001175935.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_001175936.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system YP_001175937.1 PFAM: Orn/Lys/Arg decarboxylase, major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: sec:SC0721 ornithine decarboxylase isozyme, inducible YP_001175938.1 PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: ecj:JW5096 DNA-binding response regulator in two-component regulatory system with KdpD YP_001175939.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein YP_001175940.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex YP_001175941.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_001175942.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_001175943.1 KEGG: stm:STM0708 periplasmic protein YP_001175944.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent YP_001175945.1 PFAM: protein of unknown function DUF34; KEGG: sbo:SBO_0569 hypothetical protein YP_001175946.1 PFAM: Allophanate hydrolase subunit 1; KEGG: ecv:APECO1_1364 hypothetical protein YP_001175947.1 TIGRFAM: urea amidolyase related protein; PFAM: Allophanate hydrolase subunit 2; KEGG: sbo:SBO_0571 carboxylase YP_001175948.1 PFAM: LamB/YcsF family protein; KEGG: sbo:SBO_0572 lactam utilization protein YP_001175949.1 PFAM: protein of unknown function DUF969; KEGG: yps:YPTB2907 hypothetical protein YP_001175950.1 PFAM: protein of unknown function DUF979; KEGG: ypn:YPN_1190 membrane protein YP_001175951.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline YP_001175952.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity YP_001175953.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_001175954.1 PFAM: succinate dehydrogenase, cytochrome b subunit; KEGG: ecv:APECO1_1357 succinate dehydrogenase cytochrome b-556 subunit YP_001175955.1 KEGG: sdy:SDY_0660 succinate dehydrogenase, hydrophobic subunit YP_001175956.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_001175957.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_001175958.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_001175959.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_001175960.1 catalyzes the interconversion of succinyl-CoA and succinate YP_001175961.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_001175962.1 PFAM: cytochrome bd ubiquinol oxidase, subunit I; KEGG: sbo:SBO_0592 cytochrome d terminal oxidase, polypeptide subunit I YP_001175963.1 TIGRFAM: cytochrome d ubiquinol oxidase, subunit II; PFAM: cytochrome bd ubiquinol oxidase, subunit II; KEGG: stm:STM0741 cytochrome d terminal oxidase polypeptide subunit II YP_001175964.1 TIGRFAM: cyd operon protein YbgT; PFAM: membrane bound YbgT family protein; KEGG: sdy:SDY_0682 outer membrane lipoprotein YP_001175965.1 TIGRFAM: cyd operon protein YbgE; KEGG: sec:SC0747 inner membrane lipoprotein YP_001175966.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components YP_001175967.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_001175968.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_001175969.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins YP_001175970.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_001175971.1 TIGRFAM: OmpA domain protein; PFAM: OmpA/MotB domain protein; KEGG: stm:STM0749 tol protein required for outer membrane integrity, uptake of group A colicins, and translocation of phage DNA to cytoplasm YP_001175972.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity YP_001175973.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_001175974.1 TIGRFAM: nicotinamide mononucleotide transporter PnuC; PFAM: Nicotinamide mononucleotide transporter PnuC; KEGG: sec:SC0756 NMN family, nucleoside/purine/pyrimidine transporter YP_001175975.1 involved in zinc efflux across the cytoplasmic membrane YP_001175976.1 KEGG: ecc:c0829 hypothetical protein YbgS precursor YP_001175977.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_001175978.1 TIGRFAM: phosphoglycerate mutase 1 family; PFAM: Phosphoglycerate mutase; KEGG: sec:SC0770 phosphoglyceromutase 1 YP_001175979.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose YP_001175980.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_001175981.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P YP_001175982.1 TIGRFAM: UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain; KEGG: ssn:SSO_0711 UDP-galactose-4-epimerase YP_001175983.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum YP_001175984.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons YP_001175985.1 KEGG: sdy:SDY_0709 hypothetical protein YP_001175986.1 with ModCB is involved in the high-affinity transport of molybdate YP_001175987.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE YP_001175988.1 Part of the ABC transporter complex modABC involved in molybdenum import YP_001175989.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily YP_001175990.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate YP_001175991.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family YP_001175992.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_001175993.1 catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate YP_001175994.1 TIGRFAM: histidine utilization repressor; PFAM: regulatory protein GntR, HTH; UbiC transcription regulator-associated domain protein; KEGG: stm:STM0789 histidine utilization repressor YP_001175995.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_001175996.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_001175997.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate YP_001175998.1 KEGG: ecv:APECO1_1314 biotin synthase; TIGRFAM: biotin synthase; PFAM: Radical SAM domain protein; biotin and thiamin synthesis associated; SMART: Elongator protein 3/MiaB/NifB YP_001175999.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine YP_001176000.1 methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth YP_001176001.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_001176002.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: yps:YPTB1186 ABC branched chain amino acid transporter, ATP binding subunit YP_001176003.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001176004.1 PFAM: protein of unknown function UPF0052 and CofD; KEGG: sec:SC0799 cytoplasmic protein YP_001176005.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_001176006.1 TIGRFAM: molybdenum cofactor synthesis domain; molybdenum cofactor biosynthesis protein B; PFAM: molybdopterin binding domain; KEGG: sdy:SDY_0824 molybdopterin biosynthesis, protein B YP_001176007.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_001176008.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_001176009.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_001176010.1 PFAM: protein of unknown function UPF0005; KEGG: stm:STM0807 permease YP_001176011.1 KEGG: stt:t2077 membrane protein YP_001176012.1 PFAM: phospholipase D/Transphosphatidylase; KEGG: spt:SPA1941 phospholipase YP_001176013.1 PFAM: Endonuclease/exonuclease/phosphatase; KEGG: stm:STM0813 cytoplasmic protein YP_001176014.1 KEGG: stm:STM0814 inner membrane protein YP_001176015.1 PFAM: ABC-2 type transporter; KEGG: stt:t2073 inner membrane protein YP_001176016.1 PFAM: ABC-2 type transporter; KEGG: stm:STM0816 ABC superfamily (membrane) transport protein YP_001176017.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: ecv:APECO1_1296 ABC-type transport protein YbhF YP_001176018.1 PFAM: secretion protein HlyD family protein; KEGG: stm:STM0818 membrane permeases, predicted cation efflux pump YP_001176019.1 PFAM: regulatory protein, TetR; KEGG: stm:STM0819 transcriptional repressor YP_001176020.1 this helicase is not essential cell growth YP_001176021.1 helicase involved in DNA repair and perhaps also replication YP_001176022.1 PFAM: glycosyl transferase, family 3; KEGG: ssn:SSO_0779 enzyme YP_001176023.1 PFAM: protein of unknown function DUF1471; KEGG: sec:SC0820 periplasmic protein YP_001176024.1 PFAM: zinc finger, DksA/TraR C4-type; KEGG: spt:SPA1928 hypothetical zinc-finger containing protein YP_001176025.1 PFAM: protein of unknown function DUF1471; KEGG: ssn:SSO_0786 hypothetical protein YP_001176026.1 PFAM: protein of unknown function DUF890; KEGG: spt:SPA1927 SAM-dependent methyltransferase YP_001176027.1 PFAM: MscS Mechanosensitive ion channel; KEGG: ssn:SSO_0788 transport protein YP_001176028.1 similar to ATP-binding component of ABC transporters YP_001176029.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine YP_001176030.1 similar to periplasmic-binding component of ABC transporters YP_001176031.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage YP_001176032.1 PFAM: protein of unknown function DUF6, transmembrane; KEGG: stm:STM0832 permease YP_001176033.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains YP_001176034.1 PFAM: sulfatase; KEGG: sbo:SBO_0706 enzyme YP_001176035.1 KEGG: eci:UTI89_C0820 hypothetical protein YP_001176036.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present YP_001176037.1 PFAM: Citrate transporter; KEGG: ecv:APECO1_1274 hypothetical protein YP_001176038.1 PFAM: aldo/keto reductase; KEGG: csa:Csal_0804 aldo/keto reductase YP_001176039.1 PFAM: glycoside hydrolase, family 1; KEGG: lac:LBA0885 beta-glucosidase YP_001176040.1 TIGRFAM: PTS system, lactose/cellobiose family IIC subunit; PFAM: phosphotransferase system, EIIC; KEGG: ppe:PEPE_1775 cellobiose-specific PTS system IIC component YP_001176041.1 PFAM: regulatory protein GntR, HTH; UbiC transcription regulator-associated domain protein; KEGG: lwe:lwe0887 transcriptional regulator, GntR family YP_001176042.1 PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: sdy:SDY_0777 hypothetical protein YP_001176043.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: stm:STM0838 ABC transporter ATPase component YP_001176044.1 PFAM: glycoside hydrolase, family 31; KEGG: ssn:SSO_0800 glucosidase YP_001176045.1 PFAM: major facilitator superfamily MFS_1; KEGG: ssn:SSO_0801 hexuronate transporter YP_001176046.1 PFAM: periplasmic binding protein/LacI transcriptional regulator; SMART: regulatory protein, LacI; KEGG: ssn:SSO_0802 transcriptional regulator YP_001176047.1 PFAM: protein of unknown function DUF1479; KEGG: ecj:JW0805 hypothetical protein YP_001176048.1 TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase, type 3; KEGG: stm:STM0842 hydrolase of the HAD superfamily YP_001176049.1 KEGG: ecv:APECO1_1270 formate acetyltransferase 3; TIGRFAM: pyruvate formate-lyase; PFAM: formate C-acetyltransferase glycine radical; pyruvate formate-lyase, PFL YP_001176050.1 TIGRFAM: glycyl-radical enzyme activating protein family; PFAM: Radical SAM domain protein; KEGG: spt:SPA1911 pyruvate formate-lyase 3 activating enzyme YP_001176051.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies YP_001176052.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase YP_001176053.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum YP_001176054.1 PFAM: peptidase T2, asparaginase 2; KEGG: sfx:S0821 asparaginase YP_001176055.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains YP_001176056.1 PFAM: extracellular solute-binding protein, family 5; KEGG: stt:t2040 peptide transport system substrate-binding protein YP_001176057.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: stm:STM0850 ABC transporter periplasmic binding protein YP_001176058.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: sbo:SBO_0722 transport system permease YP_001176059.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing YP_001176060.1 PFAM: glucose sorbosone dehydrogenase; KEGG: sbo:SBO_0733 dehydrogenase YP_001176061.1 PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain; KEGG: stm:STM0862 glutathione S-transferase YP_001176062.1 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_001176063.1 PFAM: regulatory protein, DeoR; Helix-turn-helix, type 11 domain protein; KEGG: stm:STM0864 deoxyribose operon transcriptional repressor YP_001176064.1 PFAM: phosphoesterase, PA-phosphatase related; KEGG: sec:SC0859 permease YP_001176065.1 PFAM: phosphoesterase, PA-phosphatase related; KEGG: yen:YE1477 hypothetical protein YP_001176066.1 PFAM: major facilitator superfamily MFS_1; KEGG: ecv:APECO1_1251 proton motive force efflux pump YP_001176067.1 TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase, type 3; KEGG: ecv:APECO1_1249 conserved hypothetical protein with a phophatase-like domain YP_001176068.1 PFAM: major facilitator superfamily MFS_1; KEGG: stm:STM0868 transport protein/regulator YP_001176069.1 PFAM: regulatory protein, TetR; KEGG: ecv:APECO1_1247 DeoR-type transcriptional regulator YP_001176070.1 PFAM: acyltransferase 3; KEGG: bsu:BG13276 similar to hypothetical proteins YP_001176072.1 PFAM: phage integrase family protein; KEGG: stt:t3400 probable bacteriophage integrase YP_001176073.1 KEGG: yps:YPTB1871 similar to hypothetical protein YP_001176074.1 PFAM: bacteriophage CI repressor; KEGG: sbo:SBO_0748 repressor protein YP_001176075.1 KEGG: ecc:c0935 regulator for prophage YP_001176076.1 PFAM: phage regulatory CII family protein; KEGG: spt:SPA2597 phage regulatory protein YP_001176077.1 KEGG: ecc:c0937 hypothetical protein YP_001176078.1 KEGG: stm:STM2733 hypothetical protein YP_001176079.1 KEGG: stm:STM2732 hypothetical protein YP_001176080.1 TIGRFAM: phage/conjugal plasmid C-4 type zinc finger protein, TraR family; PFAM: zinc finger, DksA/TraR C4-type; KEGG: spt:SPA2593 hypothetical protein YP_001176081.1 PFAM: phosphoadenosine phosphosulfate reductase; KEGG: eca:ECA2628 conserved phage protein YP_001176082.1 PFAM: bacteriophage replication gene A; KEGG: spt:SPA2590 hypothetical protein YP_001176083.1 KEGG: spt:SPA2589 hypothetical protein YP_001176084.1 KEGG: aci:ACIAD2134 hypothetical protein YP_001176087.1 TIGRFAM: phage portal protein, PBSX family; PFAM: phage portal protein; KEGG: stt:t3416 probable capsid portal protein YP_001176088.1 PFAM: protein of unknown function DUF264; KEGG: stm:STM2722 terminase-like protein YP_001176089.1 KEGG: stm:STM2697 phage tail-like protein YP_001176090.1 PFAM: phage P2 GpU family protein; KEGG: stm:STM2696 Fels-2 prophage: similar to genes in phage phiCTX YP_001176091.1 PFAM: phage late control D family protein; KEGG: stm:STM2695 Fels-2 prophage: similar to late control gene in phage YP_001176092.1 PFAM: phage transcriptional activator, Ogr/delta; KEGG: stm:STM2694 late control-like protein YP_001176093.1 PFAM: blue (type 1) copper domain protein; KEGG: bfr:BF4286 hypothetical protein YP_001176094.1 TIGRFAM: YidE/YbjL duplication; PFAM: TrkA-C domain protein; YidE/YbjL duplication domain protein; KEGG: stm:STM0870 transport protein YP_001176095.1 KEGG: stm:STM0871 inner membrane protein YP_001176096.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase YP_001176097.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds YP_001176098.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 YP_001176099.1 KEGG: sbo:SBO_0787 sensory transduction regulator YP_001176100.1 PFAM: extracellular solute-binding protein, family 1; KEGG: sbo:SBO_0788 periplasmic putrescine-binding protein YP_001176101.1 part of the PotFGHI ATP-dependent putrescine transporter YP_001176102.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: sec:SC0872 ABC superfamily (membrane), putrescine transporter YP_001176103.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: stm:STM0880 ABC superfamily (membrane), putrescine transporter YP_001176104.1 KEGG: sdy:SDY_0737 hypothetical protein YP_001176105.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA YP_001176106.1 PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: eci:UTI89_C4931 response regulator YP_001176107.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: eci:UTI89_C4932 hypothetical protein YP_001176108.1 KEGG: stm:STM0887 ABC superfamily (bind_prot), arginine 3rd transport system; TIGRFAM: cationic amino acid ABC transporter, periplasmic binding protein; PFAM: extracellular solute-binding protein, family 3; SMART: ionotropic glutamate receptor YP_001176109.1 with ArtPQJI acts to transport arginine across the inner membrane YP_001176110.1 with ArtPMJI transports arginine across the inner membrane YP_001176111.1 KEGG: stm:STM0890 ABC superfamily (bind_prot), arginine transport system; TIGRFAM: cationic amino acid ABC transporter, periplasmic binding protein; PFAM: extracellular solute-binding protein, family 3; SMART: ionotropic glutamate receptor YP_001176112.1 With ArtMQJI transports arginine across the inner membrane YP_001176113.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS YP_001176114.1 PFAM: protein of unknown function DUF74; KEGG: stm:STM0930 cytoplasmic protein YP_001176115.1 PFAM: N-acetylmuramoyl-L-alanine amidase, family 2; KEGG: sfv:SFV_0855 regulator YP_001176116.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; Male sterility C-terminal domain; KEGG: sec:SC0887 nucleoside-diphosphate-sugar epimerase YP_001176117.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; NmrA family protein; KEGG: ecv:APECO1_1225 hypothetical protein YP_001176118.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine YP_001176119.1 catalyzes the formation of acetate from pyruvate YP_001176120.1 PFAM: DoxX family protein; KEGG: eca:ECA3152 hypothetical protein YP_001176121.1 PFAM: ferredoxin; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: sdy:SDY_2391 enzyme YP_001176122.1 catalyzes the reduction of hydroxylamine to ammonia and water YP_001176123.1 PFAM: protein of unknown function DUF340, membrane; KEGG: stm:STM0938 inner membrane protein YP_001176124.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure YP_001176125.1 KEGG: ecc:c1011 predicted ATP-dependent endonuclease of the OLD family YP_001176126.1 PFAM: protein of unknown function DUF535; KEGG: stt:t1993 VirK protein YP_001176127.1 confers macrolide resistance via active drug efflux YP_001176128.1 with MacA is involved in the export of macrolide YP_001176129.1 KEGG: stm:STM0943 similar to CspA but not cold shock induced; TIGRFAM: cold shock domain protein CspD; PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein YP_001176130.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_001176131.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates YP_001176133.1 TIGRFAM: CRISPR-associated protein Cas1; KEGG: ecv:APECO1_1211 hypothetical protein YP_001176134.1 TIGRFAM: CRISPR-associated helicase Cas3 family; KEGG: ecv:APECO1_1210 hypothetical protein YP_001176135.1 TIGRFAM: CRISPR-associated protein, Csy1 family; KEGG: ecv:APECO1_1209 hypothetical protein YP_001176136.1 TIGRFAM: CRISPR-associated protein, Csy2 family; KEGG: ypn:YPN_2060 hypothetical protein YP_001176137.1 TIGRFAM: CRISPR-associated protein, Csy3 family; KEGG: ecv:APECO1_1207 hypothetical protein YP_001176138.1 TIGRFAM: CRISPR-associated protein, Csy4 family; KEGG: ecv:APECO1_1206 hypothetical protein YP_001176139.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001176140.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_001176141.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_001176142.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_001176143.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding YP_001176144.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system YP_001176145.1 DNA-binding membrane protein required for chromosome resolution and partitioning YP_001176146.1 participates with LolB in the incorporation of lipoprotein into the outer membrane YP_001176147.1 PFAM: AAA ATPase, central domain protein; SMART: AAA ATPase; KEGG: sbo:SBO_0825 polynucleotide enzyme YP_001176148.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001176149.1 TIGRFAM: anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: stm:STM0964 anaerobic dimethyl sulfoxide reductase, subunit A YP_001176150.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: stm:STM1497 dimethyl sulphoxide reductase YP_001176151.1 PFAM: DMSO reductase anchor subunit (DmsC); KEGG: stm:STM0966 anaerobic dimethyl sulfoxide reductase, subunit C YP_001176152.1 PFAM: major facilitator superfamily MFS_1; KEGG: aha:AHA_2789 major facilitator family transporter YP_001176153.1 activates pyruvate formate-lyase 1 under anaerobic conditions YP_001176154.1 KEGG: stm:STM0973 pyruvate formate lyase I; TIGRFAM: formate acetyltransferase; PFAM: formate C-acetyltransferase glycine radical; pyruvate formate-lyase, PFL YP_001176155.1 PFAM: formate/nitrite transporter; KEGG: sec:SC0928 FNT family, formate transporter (formate channel 1) YP_001176156.1 PFAM: protein of unknown function DUF181; KEGG: sbo:SBO_2191 hypothetical protein YP_001176157.1 PFAM: protein of unknown function DUF421; KEGG: sbo:SBO_2192 hypothetical protein YP_001176158.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_001176159.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_001176160.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_001176161.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001176162.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001176163.1 TIGRFAM: DNA internalization-related competence protein ComEC/Rec2; PFAM: beta-lactamase domain protein; ComEC/Rec2-related protein; KEGG: stm:STM0983 recombination protein YP_001176164.1 involved in the transport of lipid A across the inner membrane YP_001176165.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_001176166.1 PFAM: protein of unknown function DUF1006; KEGG: sbo:SBO_2204 hypothetical protein YP_001176167.1 PFAM: protein of unknown function DUF343; KEGG: sdy:SDY_2341 hypothetical protein YP_001176168.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_001176169.1 KEGG: spt:SPA1809 hypothetical protein YP_001176170.1 PFAM: protein of unknown function DUF218; KEGG: stt:t1944 hypothetical protein YP_001176171.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA YP_001176172.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division YP_001176173.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division YP_001176174.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects YP_001176175.1 PFAM: Peptidoglycan-binding domain 1 protein; KEGG: stm:STM0995 periplasmic protein YP_001176176.1 PFAM: protein of unknown function DUF882; Peptidase M15A; KEGG: sdy:SDY_2331 hypothetical protein YP_001176177.1 PFAM: beta-lactamase domain protein; KEGG: stm:STM0997 metallo-beta-lactamase YP_001176178.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_001176179.1 PFAM: porin, Gram-negative type; KEGG: stm:STM0999 outer membrane protein 1a (ia;b;f), porin YP_001176180.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001176181.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_001176182.1 TIGRFAM: aminopeptidase N; PFAM: peptidase M1, membrane alanine aminopeptidase; KEGG: stm:STM1057 aminopeptidase N YP_001176183.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease YP_001176184.1 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease YP_001176185.1 catalyzes the release of sulfite from alkanesulfonates YP_001176186.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease YP_001176187.1 PFAM: NAD(P)H dehydrogenase (quinone); NADPH-dependent FMN reductase; KEGG: ecv:APECO1_49 SsuE YP_001176188.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_001176189.1 PFAM: protein of unknown function DUF1379; KEGG: stm:STM1059 cytoplasmic protein YP_001176190.1 PFAM: ferredoxin; MOSC domain containing protein; MOSC domain protein beta barrel domain protein; KEGG: sfx:S1013 hypothetical protein YP_001176191.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_001176192.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth YP_001176193.1 TIGRFAM: integral membrane protein, PqiA family; PFAM: Paraquat-inducible protein A; KEGG: sdy:SDY_0923 paraquat-inducible protein A YP_001176194.1 PFAM: Mammalian cell entry related domain protein; KEGG: sec:SC1016 paraquat-inducible protein B YP_001176195.1 PFAM: protein of unknown function DUF330; KEGG: stm:STM1065 outer membrane protein YP_001176196.1 PFAM: ribosome modulation factor; KEGG: sdy:SDY_0926 ribosome modulation factor YP_001176197.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_001176198.1 KEGG: sbo:SBO_2276 ATP-dependent protease YP_001176199.1 PFAM: protein of unknown function DUF1047; KEGG: stm:STM1069 hypothetical protein YP_001176200.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d YP_001176201.1 PFAM: cell division inhibitor SulA; KEGG: ecc:c1095 cell division inhibitor YP_001176202.1 PFAM: TfoX, N-terminal domain protein; TfoX, C-terminal domain protein; KEGG: stm:STM1072 DNA transformation protein YP_001176203.1 TIGRFAM: hypothetical membrane protein; integral membrane protein, YccS/YhfK family; PFAM: protein of unknown function DUF893, YccS/YhfK; KEGG: stt:t1847 hypothetical protein YP_001176204.1 PFAM: protein of unknown function DUF307; KEGG: ecv:APECO1_66 hypothetical protein YP_001176205.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand YP_001176206.1 catalyzes the formation of methylglyoxal from glycerone phosphate YP_001176207.1 KEGG: sfv:SFV_0974 hypothetical protein YP_001176208.1 PFAM: CoA-binding domain protein; KEGG: sbo:SBO_2266 hypothetical protein YP_001176209.1 TIGRFAM: hemimethylated DNA binding protein; PFAM: Hemimethylated DNA-binding region; KEGG: stm:STM1079 inner membrane protein YP_001176210.1 PFAM: conserved hypothetical protein 95; SMART: PUA domain containing protein; KEGG: ecs:ECs1051 oxidoreductase YP_001176211.1 PFAM: acylphosphatase; KEGG: stm:STM1083 phosphohydrolase YP_001176212.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs YP_001176213.1 PFAM: protein of unknown function UPF0005; KEGG: stm:STM1085 TEGT family carrier/transport protein YP_001176214.1 PFAM: extracellular solute-binding protein, family 5; KEGG: plu:plu2212 unnamed protein product; highly similar to oligopeptide-binding protein precursor OppA YP_001176215.1 KEGG: vvy:VV1340 hypothetical protein YP_001176216.1 KEGG: vch:VC1124 hypothetical protein YP_001176218.1 PFAM: Cyclopropane-fatty-acyl-phospholipid synthase; Methyltransferase type 11; Methyltransferase type 12; KEGG: eca:ECA2212 cyclopropane-fatty-acyl-phospholipid synthase YP_001176219.1 PFAM: protein of unknown function DUF1365; KEGG: eca:ECA2213 hypothetical protein YP_001176220.1 PFAM: amine oxidase; FAD dependent oxidoreductase; KEGG: eca:ECA2214 amine oxidoreductase YP_001176221.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR; KEGG: eca:ECA2215 short-chain dehydrogenase YP_001176222.1 KEGG: eca:ECA2216 hypothetical protein YP_001176223.1 PFAM: major facilitator superfamily MFS_1; KEGG: xom:XOO_3974 MFS transporter YP_001176224.1 PFAM: Mig-14 family protein; KEGG: spt:SPA2638 transcriptional regulator YP_001176225.1 PFAM: GCN5-related N-acetyltransferase; KEGG: rpb:RPB_0244 GCN5-related N-acetyltransferase YP_001176226.1 TIGRFAM: transporter, hydrophobe/amphiphile efflux-1 (HAE1) family; PFAM: acriflavin resistance protein; KEGG: aav:Aave_2528 transporter, hydrophobe/amphiphile efflux-1 (HAE1) family YP_001176228.1 PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: aav:Aave_2526 two component transcriptional regulator, winged helix family YP_001176229.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: aha:AHA_1323 sensor histidine kinase YP_001176230.1 KEGG: mma:MM0768 glycosyltransferase YP_001176231.1 TIGRFAM: methionine aminopeptidase, type I; PFAM: peptidase M24; KEGG: sde:Sde_2321 methionine aminopeptidase, MAP YP_001176232.1 KEGG: pen:PSEEN1416 hypothetical protein YP_001176233.1 PFAM: GCN5-related N-acetyltransferase; KEGG: aha:AHA_3264 acetyltransferase YP_001176235.1 KEGG: llm:llmg_1171 conserved hypothetical protein YP_001176236.1 PFAM: protein of unknown function DUF1384; KEGG: sec:SC0031 hypothetical protein YP_001176237.1 PFAM: sulfatase; KEGG: stm:STM0035 arylsulfatase YP_001176238.1 PFAM: Radical SAM domain protein; KEGG: stm:STM0036 arylsulfatase regulatory protein YP_001176239.1 KEGG: stm:STM0037 cytoplasmic protein YP_001176240.1 PFAM: Arylsulfotransferase; KEGG: stt:t0040 possible sulfatase YP_001176241.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR; KEGG: eca:ECA0747 short chain dehydrogenase YP_001176242.1 PFAM: helix-turn-helix, HxlR type; KEGG: cvi:CV2176 probable transcriptional regulator YP_001176243.1 PFAM: short-chain dehydrogenase/reductase SDR; KR; KEGG: rfr:Rfer_0308 short-chain dehydrogenase/reductase SDR YP_001176244.1 PFAM: helix-turn-helix, HxlR type; KEGG: pfo:Pfl_3264 predicted transcriptional regulator YP_001176245.1 PFAM: histidine acid phosphatase; KEGG: ecp:ECP_1001 glucose-1-phosphatase precursor YP_001176246.1 KEGG: sdy:SDY_0979 hypothetical protein YP_001176247.1 stationary phase that binds TrpR repressor YP_001176248.1 KEGG: stm:STM1121 cytoplasmic protein YP_001176249.1 PFAM: protein of unknown function DUF6, transmembrane; KEGG: pst:PSPTO_3470 hypothetical protein YP_001176250.1 TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: ecp:ECP_1005 probable transport protein YcdG YP_001176251.1 PFAM: flavin reductase domain protein, FMN-binding; KEGG: sfv:SFV_1019 hypothetical protein YP_001176252.1 PFAM: nitroreductase; KEGG: ecv:APECO1_99 NADH dehydrogenase/NAD(P)H nitroreductase YP_001176253.1 PFAM: alpha/beta hydrolase fold; KEGG: ecs:ECs1255 acetyltransferase YP_001176254.1 PFAM: Endoribonuclease L-PSP; KEGG: sdy:SDY_0985 hypothetical protein YP_001176255.1 PFAM: isochorismatase hydrolase; KEGG: ssn:SSO_1030 synthetase YP_001176256.1 PFAM: luciferase family protein; KEGG: ecs:ECs1258 hypothetical protein YP_001176257.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: pfl:PFL_2294 transcriptional regulator, LysR family YP_001176258.1 PFAM: short-chain dehydrogenase/reductase SDR; KEGG: pfl:PFL_2295 oxidoreductase, short-chain dehydrogenase/reductase family YP_001176259.1 PFAM: SMP-30/Gluconolaconase/LRE domain protein; KEGG: ppu:PP_3180 Smp-30/Cgr1 family protein YP_001176260.1 PFAM: transposase, IS111A/IS1328/IS1533; transposase IS116/IS110/IS902 family protein; KEGG: cps:CPS_4852 ISCps5, transposase YP_001176261.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: bur:Bcep18194_B2563 major facilitator superfamily (MFS_1) transporter YP_001176262.1 PFAM: helix-turn-helix- domain containing protein, AraC type; KEGG: bam:Bamb_5293 transcriptional regulator, AraC family YP_001176263.1 PFAM: chloramphenicol acetyltransferase; KEGG: sty:HCM1.206 chloramphenicol acetyltransferase YP_001176264.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; KEGG: atc:AGR_L_2664 hypothetical protein YP_001176265.1 KEGG: atc:AGR_L_2662 hypothetical protein YP_001176267.1 KEGG: pfl:PFL_2668 hypothetical protein YP_001176268.1 KEGG: pfl:PFL_2669 lipoprotein YP_001176269.1 PFAM: regulatory protein, TetR; Tetracycline transcriptional regulator YcdC, C-terminal domain protein; KEGG: ecs:ECs1259 tet operon regulator YP_001176270.1 PFAM: protein of unknown function DUF1311; KEGG: stm:STM1123 periplasmic protein YP_001176271.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein YP_001176272.1 TIGRFAM: SSS sodium solute transporter superfamily; sodium/proline symporter; PFAM: Na+/solute symporter; KEGG: ecj:JW1001 proline:sodium symporter YP_001176273.1 KEGG: eca:ECA3515 lipoprotein YP_001176274.1 PFAM: Na+ dependent nucleoside transporter; nucleoside recognition domain protein; Na+ dependent nucleoside transporter domain protein; KEGG: yen:YE0051 nucleoside permease YP_001176275.1 TIGRFAM: FTR1 family protein; PFAM: iron permease FTR1; KEGG: ssn:SSO_1036 high-affinity iron permease YP_001176276.1 PFAM: protein of unknown function DUF451; KEGG: ssn:SSO_1037 hypothetical protein YP_001176277.1 TIGRFAM: Dyp-type peroxidase family; PFAM: Dyp-type peroxidase; KEGG: ecp:ECP_1018 hypothetical protein YcdB precursor YP_001176278.1 PFAM: PhoH family protein; KEGG: ecp:ECP_1019 PhoH protein YP_001176279.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: sdy:SDY_1004 dehydrogenase YP_001176280.1 PFAM: PHP C-terminal domain protein; SMART: phosphoesterase PHP domain protein; KEGG: stm:STM1136 histidinol phosphatase YP_001176281.1 PFAM: cytoplasmic chaperone TorD family protein; KEGG: ecv:APECO1_120 hypothetical protein YP_001176282.1 PFAM: protein of unknown function DUF1097; KEGG: spt:SPA1713 hypothetical protein YP_001176283.1 PFAM: Curli production assembly/transport component CsgG; KEGG: ecv:APECO1_122 assembly/transport component in curli production YP_001176284.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex YP_001176285.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex YP_001176286.1 activates the csgBA and csgDEFG operons involved in biofilm formation YP_001176287.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface YP_001176288.1 PFAM: Curlin associated repeat protein; KEGG: ecv:APECO1_127 curlin major subunit CsgA YP_001176289.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers YP_001176290.1 KEGG: ecj:JW1031 hypothetical protein YP_001176291.1 PFAM: Appr-1-p processing domain protein; KEGG: sbo:SBO_2021 polyprotein YP_001176292.1 PFAM: phospholipase D/Transphosphatidylase; KEGG: stm:STM1148.S phospholipase YP_001176293.1 required for the transfer of succinyl residues to the glucan backbone YP_001176294.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan YP_001176295.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space YP_001176296.1 PFAM: protein of unknown function DUF1375; KEGG: ssn:SSO_1064 hypothetical protein YP_001176297.1 multicopy suppressor of SecY; KEGG: spt:SPA1698 acidic protein MsyB; multicopy suppressor of SecY YP_001176298.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_001176299.1 PFAM: Rhodanese domain protein; KEGG: sfv:SFV_1078 hypothetical protein YP_001176300.1 PFAM: YceI family protein; KEGG: stm:STM1157 hypothetical protein YP_001176301.1 PFAM: cytochrome B561; KEGG: eci:UTI89_C1181 cytochrome b561-like protein 2 YP_001176302.1 KEGG: stm:STM1159 inner membrane protein YP_001176303.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids YP_001176304.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing YP_001176305.1 PFAM: DinI family protein; KEGG: stm:STM1162 DNA damage-inducible protein I YP_001176306.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_001176307.1 PFAM: protein of unknown function DUF1439; KEGG: stm:STM1164 outer membrane lipoprotein YP_001176308.1 cofactor involved in the reduction of disulfides YP_001176309.1 Confers resistance to norfloxacin and enoxacin YP_001176310.1 PFAM: GCN5-related N-acetyltransferase; KEGG: stm:STM1167 acetylation of N-terminal alanine of 30S ribosomal subunit protein S5 YP_001176311.1 PFAM: protein of unknown function DUF480; KEGG: ecp:ECP_1059 hypothetical protein YceH YP_001176312.1 PFAM: oxidoreductase domain protein; Oxidoreductase, C-terminal domain; KEGG: ecj:JW1055 predicted oxidoreductase, NAD(P)-binding Rossmann-fold domain YP_001176313.1 TIGRFAM: integral membrane protein MviN; PFAM: virulence factor MVIN family protein; KEGG: stm:STM1170 virulence factor YP_001176314.1 PFAM: FlgN family protein; KEGG: stm:STM1171 flagellar biosynthesis: belived to be export chaperone for FlgK and FlgL YP_001176315.1 regulates the flagellar specific sigma28 transcription factor YP_001176316.1 required for the assembly of the flagellar basal body P-ring YP_001176317.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella YP_001176318.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_001176319.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production YP_001176320.1 the hook connects flagellar basal body to the flagellar filament YP_001176321.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod YP_001176322.1 makes up the distal portion of the flagellar basal body rod YP_001176323.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod YP_001176324.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_001176325.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space YP_001176326.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_001176327.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes YP_001176328.1 PFAM: major facilitator superfamily MFS_1; KEGG: azo:azo0582 permeases of the major facilitator superfamily YP_001176329.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: aav:Aave_2533 transcriptional regulator, LysR family YP_001176330.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase YP_001176331.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA YP_001176332.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_001176333.1 PFAM: protein of unknown function DUF177; KEGG: stm:STM1190 metal-binding YP_001176334.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001176335.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_001176336.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_001176337.1 TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: acyl transferase domain protein; KEGG: stm:STM1194 malonyl-CoA-[acyl-carrier-protein] transacylase YP_001176338.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001176339.1 carries the fatty acid chain in fatty acid biosynthesis YP_001176340.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001176341.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate YP_001176342.1 PFAM: aminodeoxychorismate lyase; KEGG: sbo:SBO_1966 thymidylate kinase YP_001176343.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_001176344.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_001176345.1 TIGRFAM: hydrolase, TatD family; PFAM: TatD-related deoxyribonuclease; KEGG: sdy:SDY_2050 hypothetical protein YP_001176346.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001176347.1 TIGRFAM: TonB-dependent siderophore receptor; PFAM: TonB-dependent receptor; TonB-dependent receptor, plug; KEGG: ecs:ECs1480 outer membrane receptor for ferric iron uptake YP_001176348.1 PFAM: histidine triad (HIT) protein; KEGG: stm:STM1205 protein kinase C inhibitor YP_001176349.1 PFAM: protein of unknown function DUF1425; KEGG: spt:SPA1645 lipoprotein YP_001176350.1 KEGG: eci:UTI89_C1233 fibronectin-binding protein B YP_001176351.1 catalyzes the phosphorylation of thiamine to thiamine phosphate YP_001176352.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_001176353.1 PFAM: protein of unknown function UPF0227; KEGG: sdy:SDY_2042 hypothetical protein YP_001176354.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; FAD dependent oxidoreductase; KEGG: stt:t1709 NADH dehydrogenase YP_001176355.1 PFAM: 17 kDa surface antigen; KEGG: stm:STM1212 outer membrane lipoprotein YP_001176356.1 PFAM: regulatory protein, TetR; KEGG: sec:SC1163 transcriptional repressor (TetR/AcrR family) YP_001176357.1 PFAM: protein of unknown function DUF1471; KEGG: sdy:SDY_2038 hypothetical protein YP_001176358.1 PFAM: Peptidoglycan-binding LysM; ErfK/YbiS/YcfS/YnhG family protein; KEGG: sec:SC1165 periplasmic protein YP_001176359.1 KEGG: stm:STM1216 transcription-repair coupling factor; TIGRFAM: transcription-repair coupling factor; PFAM: helicase domain protein; transcription factor CarD; TRCF domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001176360.1 PFAM: acyltransferase 3; KEGG: ecs:ECs1493 hypothetical protein YP_001176361.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_001176362.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone YP_001176363.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_001176364.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine YP_001176365.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_001176366.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate YP_001176367.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component YP_001176368.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component YP_001176369.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase YP_001176370.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_001176371.1 PFAM: Cupin 4 family protein; SMART: transcription factor jumonji, jmjC domain protein; KEGG: sbo:SBO_1911 hypothetical protein YP_001176372.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: stm:STM1230 sensory kinase in two-component regulatory system with PhoP, ligand is Mg+ YP_001176373.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress YP_001176374.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_001176375.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_001176376.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001176377.1 PFAM: NUDIX hydrolase; KEGG: stm:STM1235 MutT-like protein YP_001176378.1 PFAM: pseudouridine synthase; KEGG: ecp:ECP_1130 ribosomal large subunit pseudouridine synthase YP_001176379.1 Converts isocitrate to alpha ketoglutarate YP_001176380.1 PFAM: phage integrase family protein; KEGG: ecv:APECO1_219 prophage lambda integrase YP_001176381.1 TIGRFAM: phage terminase, small subunit, , P27 family; PFAM: phage terminase, small subunit, , P27; KEGG: ssn:SSO_2780 hypothetical bacteriophage protein YP_001176382.1 KEGG: ssn:SSO_2779 hypothetical bacteriophage protein YP_001176383.1 KEGG: plu:plu3180 hypothetical protein YP_001176384.1 PFAM: DNA circulation family protein; KEGG: sfv:SFV_0249 tail/DNA circulation protein YP_001176385.1 KEGG: fra:Francci3_0890 hypothetical protein YP_001176386.1 PFAM: DinI family protein; KEGG: stm:STM1241 Macrophage survival gene; reduced mouse virulence YP_001176387.1 KEGG: rfr:Rfer_2225 methyl-accepting chemotaxis sensory transducer YP_001176388.1 PFAM: Transglycosylase-associated protein; KEGG: sdy:SDY_1695 hypothetical protein YP_001176389.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; GAF domain protein; KEGG: ecj:JW5292 predicted diguanylate cyclase YP_001176390.1 PFAM: protein of unknown function DUF333; KEGG: sfx:S1546 hypothetical protein YP_001176391.1 KEGG: spt:SPA1568 hypothetical protein YP_001176392.1 PFAM: protein of unknown function DUF488; KEGG: sbo:SBO_1301 hypothetical protein YP_001176393.1 PFAM: protein of unknown function DUF523; KEGG: bch:Bcen2424_5367 protein of unknown function DUF523 YP_001176394.1 KEGG: pfl:PFL_4536 hypothetical protein YP_001176395.1 TIGRFAM: cyanate transporter; PFAM: major facilitator superfamily MFS_1; KEGG: stm:STM1278 MFS family transport protein (amino acid/amine transport) YP_001176396.1 PFAM: helix-turn-helix- domain containing protein, AraC type; Cupin 2, conserved barrel domain protein; KEGG: spt:SPA1565 transcriptional regulator YP_001176397.1 PFAM: protein of unknown function DUF441; KEGG: sec:SC1291 hypothetical protein YP_001176398.1 PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: sfx:S1552 hypothetical protein YP_001176399.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: ecv:APECO1_658 hypothetical protein YP_001176400.1 PFAM: protein of unknown function DUF444; KEGG: stt:t1163 hypothetical protein YP_001176401.1 PFAM: PrkA serine kinase; PrkA AAA domain protein; KEGG: stm:STM1285 Ser protein kinase YP_001176402.1 PFAM: MltA-interacting MipA family protein; KEGG: stm:STM1286 scaffolding protein for murein-synthesizing holoenzyme YP_001176403.1 PFAM: aldo/keto reductase; KEGG: stm:STM1288 aldehyde reductase YP_001176404.1 PFAM: Aldose 1-epimerase; KEGG: stm:STM1289 aldose 1-epimerase YP_001176405.1 KEGG: sdy:SDY_1488 glyceraldehyde-3-phosphate dehydrogenase A; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase YP_001176406.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_001176407.1 PFAM: protein of unknown function DUF1315; KEGG: stm:STM1292 cytoplasmic protein YP_001176408.1 PFAM: HNH endonuclease; SMART: HNH nuclease; KEGG: stm:STM0411 cytoplasmic protein YP_001176409.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide YP_001176410.1 converts asparagine to aspartate and ammonia YP_001176411.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane YP_001176412.1 PFAM: nitroreductase; KEGG: sbo:SBO_1322 hypothetical protein YP_001176413.1 catalyzes the formation of selenophosphate from selenide and ATP YP_001176414.1 decatenates replicating daughter chromosomes YP_001176415.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_001176416.1 PFAM: protein of unknown function DUF1496; KEGG: ecj:JW1749 hypothetical protein YP_001176417.1 PFAM: NUDIX hydrolase; KEGG: sec:SC1323 mutator MutT protein YP_001176418.1 PFAM: Carboxymuconolactone decarboxylase; KEGG: ecj:JW1742 conserved hypothetical protein YP_001176419.1 PFAM: CDP-alcohol phosphatidyltransferase; KEGG: sfx:S1582 cytochrome oxidase YP_001176420.1 PFAM: Rhodanese domain protein; KEGG: ecv:APECO1_827 thiosulfate sulfurtransferase YnjE precursor YP_001176421.1 PFAM: ABC transporter related; KEGG: sdy:SDY_1519 ATP-binding component of a transport system YP_001176422.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ecp:ECP_1701 hypothetical ABC transporter permease YnjC YP_001176423.1 KEGG: ssn:SSO_1403 hypothetical protein YP_001176424.1 KEGG: sal:Sala_2701 pyridine nucleotide-disulphide oxidoreductase dimerisation region YP_001176425.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction YP_001176426.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate YP_001176427.1 PFAM: arginine N-succinyltransferase beta subunit; KEGG: ecs:ECs2453 arginine N-succinyltransferase YP_001176428.1 PFAM: aldehyde dehydrogenase; KEGG: ecj:JW5282 succinylglutamic semialdehyde dehydrogenase YP_001176429.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation YP_001176430.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism YP_001176431.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP YP_001176432.1 PFAM: protein of unknown function DUF886; KEGG: sbo:SBO_1348 hypothetical protein YP_001176433.1 3' incision activity; acts with UvrC YP_001176434.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_001176435.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein YP_001176436.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport YP_001176437.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport YP_001176438.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport YP_001176439.1 represses the celABCDF-ydjC operon involved in carbon uptake YP_001176440.1 PFAM: glycoside hydrolase, family 4; KEGG: ecv:APECO1_803 6-phospho-beta-glucosidase YP_001176441.1 PFAM: YdjC family protein; KEGG: spt:SPA1527 hypothetical protein YP_001176442.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide YP_001176443.1 KEGG: ecv:APECO1_800 cell division activator YP_001176444.1 PFAM: sodium:dicarboxylate symporter; KEGG: spt:SPA1524 sodium:dicarboxylate symporter YP_001176445.1 PFAM: membrane-bound metal-dependent hydrolase; KEGG: sdy:SDY_1821 hypothetical protein YP_001176446.1 TIGRFAM: 2-deoxy-D-gluconate 3-dehydrogenase; PFAM: short-chain dehydrogenase/reductase SDR; KEGG: sfv:SFV_2920 2-deoxy-D-gluconate 3-dehydrogenase YP_001176447.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate YP_001176448.1 KEGG: stm:STM1323 regulatory protein YP_001176449.1 PFAM: aminoglycoside phosphotransferase; fructosamine kinase; KEGG: ecv:APECO1_795 phosphotransferase/kinase YP_001176450.1 KEGG: sec:SC1346 cytoplasmic protein YP_001176451.1 PFAM: PfkB domain protein; KEGG: stm:STM1326 6-phosphofructokinase II YP_001176452.1 PFAM: protein of unknown function DUF481; KEGG: ssn:SSO_1435 hypothetical protein YP_001176454.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001176455.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_001176456.1 PFAM: ribosomal protein L35; KEGG: sdy:SDY_1812 50S ribosomal subunit protein A YP_001176457.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001176458.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001176459.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001176460.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001176461.1 with BtuD and BtuF transports vitamin B12 into the cell YP_001176462.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane YP_001176463.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell YP_001176464.1 PFAM: NLP/P60 protein; KEGG: stm:STM1343 lipoprotein YP_001176465.1 KEGG: stm:STM1344 hypothetical protein YP_001176466.1 PFAM: protein of unknown function UPF0061; KEGG: sfv:SFV_1518 hypothetical protein YP_001176467.1 with HmuTU is involved in the transport of hemin YP_001176468.1 PFAM: transport system permease; KEGG: sgl:SG1539 hemin ABC transporter permease component YP_001176469.1 PFAM: periplasmic binding protein; KEGG: eca:ECA1845 hemin-binding periplasmic protein YP_001176470.1 PFAM: Haemin-degrading family protein; KEGG: ecs:ECs4379 hemin transport protein YP_001176471.1 TIGRFAM: TonB-dependent hemoglobin/transferrin/lactoferrin family receptor; TonB-dependent heme/hemoglobin receptor family protein; PFAM: TonB-dependent receptor; TonB-dependent receptor, plug; KEGG: ecv:APECO1_2948 outer membrane heme/hemoglobin receptor ChuA YP_001176472.1 KEGG: stm:STM1346 cytoplasmic protein YP_001176473.2 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate YP_001176474.1 PFAM: protein of unknown function DUF299; KEGG: sdy:SDY_1797 hypothetical protein YP_001176475.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001176476.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function YP_001176477.1 PFAM: FAD linked oxidase domain protein; KEGG: ecs:ECs2394 oxidase YP_001176478.1 PFAM: thioesterase superfamily protein; KEGG: stm:STM1366 hypothetical protein YP_001176479.1 KEGG: ssn:SSO_1471 hypothetical protein YP_001176480.1 KEGG: eca:ECA1408 formate dehydrogenase, nitrate-inducible, major subunit; TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region YP_001176481.1 TIGRFAM: formate dehydrogenase, beta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: stm:STM1569 formate dehydrogenase, iron-sulfur subunit (formate dehydrogenase beta subunit) YP_001176482.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase YP_001176483.1 TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: eca:ECA1250 formate dehydrogenase H YP_001176484.1 KEGG: ecj:JW1153 hypothetical protein YP_001176486.1 KEGG: ecp:ECP_1201 hypothetical protein YcgZ YP_001176487.1 PFAM: EAL domain protein; BLUF domain protein; KEGG: ecj:JW1150 predicted FAD-binding phosphodiesterase YP_001176488.1 PFAM: regulatory protein, MerR; KEGG: ecv:APECO1_277 transcriptional regulator YP_001176489.1 PFAM: CsbD family protein; protein of unknown function DUF883, ElaB YP_001176490.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein YP_001176491.1 with SufCD activates cysteine desulfurase SufS YP_001176492.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE YP_001176493.1 with SufBC activates cysteine desulfurase SufS YP_001176494.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine YP_001176495.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine YP_001176496.1 PFAM: Peptidoglycan-binding LysM; ErfK/YbiS/YcfS/YnhG family protein; KEGG: stm:STM1375 hypothetical protein YP_001176497.1 PFAM: LPP repeat-containing protein; KEGG: stm:STM1377 murein lipoprotein, links outer and inner membranes YP_001176498.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001176499.1 PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: plu:plu0523 unnamed protein product; similar to cystathionine gamma-lyase YP_001176500.1 PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: yen:YE1470 cystathionine beta-lyase YP_001176501.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: gka:GK2999 ABC transporter (ATP-binding protein) YP_001176502.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: gka:GK2998 ABC transporter (permease) YP_001176503.1 PFAM: NLPA lipoprotein; KEGG: gka:GK2997 amino acid ABC transporter (substrate binding protein) (lipoprotein) YP_001176504.1 KEGG: sdy:SDY_1904 hypothetical protein YP_001176505.1 TIGRFAM: outer membrane autotransporter barrel domain; PFAM: Autotransporter beta- domain protein; KEGG: reu:Reut_B4997 outer membrane autotransporter barrel YP_001176506.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: wbr:WGLp188 ABC-type amino acid transport system, permease component YP_001176507.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: wbr:WGLp189 ABC-type amino acid transport system, permease component YP_001176508.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: ret:RHE_PC00181 probable amino acid ABC transporter, ATP-binding protein YP_001176509.1 PFAM: extracellular solute-binding protein, family 3; SMART: ionotropic glutamate receptor; KEGG: wbr:WGLp191 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain YP_001176510.1 KEGG: csa:Csal_1011 beta-lactamase-like protein YP_001176511.1 PFAM: carbonic anhydrase; KEGG: bam:Bamb_5945 carbonate dehydratase YP_001176512.1 PFAM: FAD dependent oxidoreductase; KEGG: ecj:JW1658 conserved hypothetical protein with FAD/NAD(P)-binding domain YP_001176513.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones YP_001176514.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_001176515.1 PFAM: sugar-specific permease, SgaT/UlaA; KEGG: bcl:ABC1105 PTS sysytem, mannitol-specific enzyme II, C component YP_001176516.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge YP_001176517.1 uncharacterized member of the major facilitator superfamily (MFS) YP_001176518.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: spt:SPA1424 transcriptional regulator YP_001176519.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers YP_001176520.1 PFAM: major facilitator superfamily MFS_1; KEGG: sdy:SDY_1883 transport protein YP_001176521.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals YP_001176522.1 PFAM: NLP/P60 protein; KEGG: ecs:ECs2364 lipoprotein YP_001176523.1 TIGRFAM: glutaredoxin-like protein; PFAM: glutaredoxin; KEGG: stm:STM1433 glutaredoxin protein YP_001176524.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_001176525.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione YP_001176526.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide YP_001176527.1 PFAM: regulatory protein, TetR; KEGG: sfv:SFV_1668 hypothetical protein YP_001176528.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division YP_001176529.1 PFAM: protein of unknown function DUF1289; KEGG: sec:SC1457 oxidoreductase YP_001176530.1 PFAM: aldo/keto reductase; KEGG: ecj:JW1639 predicted oxidoreductase YP_001176531.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water YP_001176532.1 PFAM: Fusaric acid resistance protein conserved region; KEGG: spt:SPA1412 hypothetical protein YP_001176533.1 PFAM: secretion protein HlyD family protein; KEGG: spt:SPA1411 HlyD-family protein YP_001176534.1 PFAM: protein of unknown function DUF1656; KEGG: sdy:SDY_1866 hypothetical protein YP_001176535.1 Transcription regulator that can both activate or repress expression YP_001176536.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: ecp:ECP_1024 hypothetical protein YcdT YP_001176537.1 PFAM: 17 kDa surface antigen; KEGG: stm:STM1445 outer membrane lipoprotein YP_001176538.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_001176539.1 MliC; membrane-bound lysozyme inhibitor of c-type lysozyme YP_001176540.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_001176541.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_001176542.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_001176543.1 PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain; KEGG: sdy:SDY_1858 glutathionine S-transferase YP_001176544.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation YP_001176545.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines YP_001176546.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase YP_001176547.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen YP_001176548.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents YP_001176549.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_001176550.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_001176551.1 TIGRFAM: electron transport complex, RnfABCDGE type, A subunit; PFAM: RnfA-Nqr electron transport subunit; KEGG: sdy:SDY_1850 hypothetical protein YP_001176552.1 KEGG: stm:STM1460 inner membrane protein YP_001176553.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes YP_001176554.1 PFAM: Semialdehyde dehydrogenase, NAD - binding; oxidoreductase domain protein; Oxidoreductase, C-terminal domain; KEGG: sbo:SBO_1510 hypothetical protein YP_001176555.1 catalyzes the formation of inosine from adenosine YP_001176556.1 PFAM: aminotransferase, class I and II; KEGG: ssn:SSO_1536 enzyme that may degrade or block biosynthesis of endogenous mal inducer, probably aminotrasferase YP_001176557.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site YP_001176558.1 regulates malXY which are involved in maltose-glucose transport YP_001176559.1 PFAM: protein of unknown function DUF945; KEGG: stm:STM1466 periplasmic protein YP_001176560.1 KEGG: ecs:ECs2319 mannose-6-phosphate isomerase; TIGRFAM: mannose-6-phosphate isomerase, class I; PFAM: mannose-6-phosphate isomerase, type I YP_001176561.1 TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate alpha region; Fe-S type hydro-lyase tartrate/fumarate beta region; KEGG: sfv:SFV_1628 fumarate hydratase class I, aerobic YP_001176562.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001176563.1 binds to DNA replication terminator sequences to prevent passage of replication forks YP_001176564.1 TIGRFAM: nickel ABC transporter, periplasmic nickel-binding protein; PFAM: extracellular solute-binding protein, family 5; KEGG: ecv:APECO1_2978 nickel-binding periplasmic protein precursor NikA YP_001176565.1 with NikACDE is involved in nickel transport into the cell YP_001176566.1 with NikABDE is involved in nickel transport into the cell YP_001176567.1 with NikABCE is involved in nickel transport into the cell YP_001176568.1 with NikABCD is involved with nickel transport into the cell YP_001176569.1 Inhibits transcription at high concentrations of nickel YP_001176570.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: stt:t1339 two component sensor kinase YP_001176571.1 PFAM: Bor family protein; KEGG: eca:ECA2067 lipoprotein YP_001176573.1 response regulator in two-component regulatory system with RstB YP_001176574.1 PFAM: GlpM family protein; KEGG: spt:SPA1379 hypothetical protein YP_001176575.1 PFAM: short-chain dehydrogenase/reductase SDR; KEGG: ecv:APECO1_689 oxidoreductase YP_001176576.1 TIGRFAM: arginine/ornithine antiporter; PFAM: amino acid permease-associated region; KEGG: ecs:ECs2311 arginine/ornithine antiporter YP_001176577.1 PFAM: protein of unknown function DUF1471; KEGG: stm:STM1478 periplasmic protein YP_001176578.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_001176579.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme YP_001176580.1 with UspC and UspD is involved in resistance to UV irradiation YP_001176581.1 KEGG: eca:ECA3123 hypothetical protein YP_001176582.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia YP_001176583.1 KEGG: sbo:SBO_1726 O-6-alkylguanine-DNA/cysteine-protein methyltransferase; TIGRFAM: methylated-DNA--protein-cysteine methyltransferase; PFAM: methylated-DNA-[protein]-cysteine S-methyltransferase; methylguanine DNA methyltransferase, ribonuclease domain protein YP_001176584.1 KEGG: sbo:SBO_1725 pump protein (transport) YP_001176585.1 PFAM: Smr protein/MutS2; KEGG: ecc:c1814 hypothetical protein YdaL YP_001176586.1 PFAM: ligand binding Tar domain protein; histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; KEGG: stm:STM3577 methyl-accepting transmembrane citrate/phenol chemoreceptor YP_001176587.1 PFAM: aldo/keto reductase; KEGG: rle:pRL100446 aldo-keto reductase YP_001176588.1 PFAM: MltA-interacting MipA family protein; KEGG: rso:RSc3065 hypothetical protein YP_001176589.1 PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: cvi:CV0891 transcriptional regulatory protein qseB YP_001176590.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: bur:Bcep18194_A5948 periplasmic sensor signal transduction histidine kinase YP_001176592.1 PFAM: major facilitator superfamily MFS_1; KEGG: nca:Noca_0885 major facilitator superfamily MFS_1 YP_001176593.1 KEGG: rpe:RPE_2982 alpha/beta hydrolase fold YP_001176594.1 KEGG: son:SO3698 hypothetical protein YP_001176595.1 PFAM: YadA C-terminal domain protein; KEGG: ecs:ECs0548 adhesin/invasin-like protein YP_001176597.1 PFAM: Antibiotic biosynthesis monooxygenase; KEGG: rru:Rru_A0389 antibiotic biosynthesis monooxygenase YP_001176598.1 KEGG: sme:SMb20003 pyrroline-5-carboxylate reductase YP_001176599.1 TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein; KEGG: eca:ECA2932 outer membrane efflux lipoprotein YP_001176600.1 PFAM: regulatory protein, TetR; KEGG: eca:ECA2931 TetR-family transcriptional regulator YP_001176601.1 TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; KEGG: eca:ECA2930 HlyD-family secretion protein YP_001176602.1 PFAM: acriflavin resistance protein; KEGG: eca:ECA2929 efflux protein YP_001176603.1 PFAM: Antibiotic biosynthesis monooxygenase; KEGG: eca:ECA1485 lipoprotein YP_001176604.1 PFAM: aldo/keto reductase; KEGG: mpt:Mpe_A1746 oxidoreductase YP_001176605.1 KEGG: eca:ECA1484 hypothetical protein YP_001176606.1 PFAM: NAD(P)H dehydrogenase (quinone); KEGG: eca:ECA1483 NAD(P)H oxidoreductase YP_001176607.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: eca:ECA1482 LysR-family transcriptional regulator YP_001176608.1 KEGG: pde:Pden_2566 hypothetical protein YP_001176609.1 KEGG: eca:ECA1674 hypothetical protein YP_001176610.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: eca:ECA2976 LysR-family transcriptional regulator YP_001176611.1 KEGG: eca:ECA2977 hypothetical protein YP_001176612.1 KEGG: eca:ECA2978 hypothetical protein YP_001176613.1 PFAM: beta-lactamase domain protein; KEGG: eca:ECA2979 probable hydrolase YP_001176614.1 KEGG: eca:ECA2238 hypothetical protein YP_001176615.1 PFAM: YebG family protein; KEGG: sdy:SDY_1134 hypothetical protein YP_001176616.1 PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: bxe:Bxe_B0571 carbon-nitrogen hydrolase YP_001176617.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: aha:AHA_3236 isoleucine biosynthesis transcriptional activator YP_001176618.1 PFAM: helix-turn-helix- domain containing protein, AraC type; KEGG: eca:ECA3896 right origin-binding protein YP_001176619.1 TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; KEGG: xac:XAC1482 RND multidrug efflux membrane fusion protein YP_001176620.1 TIGRFAM: transporter, hydrophobe/amphiphile efflux-1 (HAE1) family; PFAM: acriflavin resistance protein; KEGG: xac:XAC1483 RND multidrug efflux transporter MexF YP_001176621.1 PFAM: protein of unknown function UPF0074; KEGG: reu:Reut_A2073 hypothetical protein YP_001176622.1 PFAM: protein of unknown function DUF1470; KEGG: bbr:BB0827 hypothetical protein YP_001176623.1 PFAM: alpha/beta hydrolase fold; KEGG: bbr:BB0826 hydrolase YP_001176624.1 catalyzes the interconversion of chorismate to prephenate YP_001176625.1 PFAM: major facilitator superfamily MFS_1; KEGG: aci:ACIAD2531 arabinose exporter (MFS superfamily) YP_001176626.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: sil:SPOA0344 transcriptional regulator, LysR family YP_001176627.1 KEGG: ppr:PBPRA1979 hypothetical lysophospholipase YP_001176628.1 outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA YP_001176631.1 PFAM: DinB family protein; KEGG: bmb:BruAb1_0712 hypothetical protein YP_001176632.1 PFAM: Lysine exporter protein (LYSE/YGGA); KEGG: pfl:PFL_3022 transporter, LysE family YP_001176633.1 PFAM: helix-turn-helix- domain containing protein, AraC type; AraC protein, arabinose-binding/dimerisation; KEGG: ppu:PP_3022 transcriptional regulator, AraC family YP_001176634.1 PFAM: peptidase S24, S26A and S26B; KEGG: sbo:SBO_1889 UmuD YP_001176635.1 PFAM: UMUC domain protein DNA-repair protein; KEGG: spt:SPA0873 UmuC protein YP_001176636.1 PFAM: Alcohol dehydrogenase GroES domain protein; KEGG: bcz:BCZK0911 NADPH:quinone reductase (quinone oxidoreductase) YP_001176637.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes YP_001176638.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS YP_001176639.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS YP_001176640.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; KEGG: atc:AGR_L_758 hypothetical protein YP_001176641.1 PFAM: peptidase S1 and S6, chymotrypsin/Hap; KEGG: stm:STM1484 protease YP_001176642.1 PFAM: Acid shock repeat protein; KEGG: yen:YE0933 acid shock protein YP_001176643.1 PFAM: peptidase M32, carboxypeptidase Taq metallopeptidase; KEGG: yps:YPTB2232 carboxypeptidase YP_001176644.1 PFAM: major facilitator superfamily MFS_1; KEGG: ssn:SSO_1568 transport protein YP_001176645.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: stt:t1408 regulatory protein YP_001176646.1 PFAM: ROK family protein; KEGG: spt:SPA1366 regulatory protein YP_001176647.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_001176648.1 KEGG: spt:SPA1363 ABC transporter ATP/GTP-binding protein; TIGRFAM: glycine betaine/L-proline ABC transporter, ATPase subunit; PFAM: CBS domain containing protein; ABC transporter related; SMART: AAA ATPase YP_001176649.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: stm:STM1492 binding-protein-dependent transport system, inner membrane component YP_001176650.1 PFAM: Substrate-binding region of ABC-type glycine betaine transport system; KEGG: stm:STM1493 periplasmic component, ABC transport system YP_001176651.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: stm:STM1494 ABC-type transport systems, permease components YP_001176652.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane YP_001176653.1 PFAM: protein of unknown function DUF1161; KEGG: ecv:APECO1_669 hypothetical protein YP_001176654.1 PFAM: O-methyltransferase, family 2; KEGG: yen:YE1418 O-methyltransferase YP_001176655.1 KEGG: stm:STM1501 hypothetical protein YP_001176656.1 PFAM: GCN5-related N-acetyltransferase; KEGG: ecv:APECO1_667 spermidine N1-acetyltransferase YP_001176657.1 PFAM: protein of unknown function DUF1283; KEGG: stm:STM1503 periplasmic protein YP_001176658.1 PFAM: protein of unknown function UPF0060; KEGG: sfv:SFV_1562 hypothetical protein YP_001176659.1 PFAM: Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein; Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein; KEGG: ecv:APECO1_664 starvation sensing protein RspA YP_001176660.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: stm:STM1506 dehydrogenase YP_001176661.1 TIGRFAM: metabolite/H+ symporter, major facilitator superfamily (MFS); PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: stt:t1428 membrane transport protein YP_001176662.1 PFAM: Mannitol dehydrogenase, C-terminal domain; Mannitol dehydrogenase rossman, N-terminal domain; KEGG: ecs:ECs2151 oxidoreductase YP_001176663.1 KEGG: stm:STM1509 cytoplasmic protein YP_001176664.1 PFAM: UspA domain protein; KEGG: ecv:APECO1_1442 universal stress protein UspG YP_001176665.1 PFAM: regulatory protein GntR, HTH; GntR domain protein; KEGG: sec:SC1527 regulatory protein, GntR family YP_001176666.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine YP_001176667.1 PFAM: peptidase M3A and M3B, thimet/oligopeptidase F; KEGG: spt:SPA1343 dipeptidyl carboxypeptidase II YP_001176669.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: ecj:JW1375 fermentative D-lactate dehydrogenase, NAD-dependent YP_001176670.1 KEGG: eci:UTI89_C1624 hypothetical protein YdbH YP_001176671.1 KEGG: stm:STM1645 outer membrane lipoprotein YP_001176672.1 PFAM: uncharacterised conserved protein UCP025560; KEGG: stm:STM1644 periplasmic protein YP_001176673.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: sec:SC1868 hypothetical protein YP_001176674.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds YP_001176675.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain YP_001176676.1 TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein; KEGG: sat:SYN_02946 type I secretion outer membrane protein YP_001176677.1 PFAM: secretion protein HlyD family protein; KEGG: pfl:PFL_2541 HlyD family secretion protein YP_001176678.1 PFAM: major facilitator superfamily MFS_1; KEGG: pfl:PFL_2540 transporter YP_001176679.1 PFAM: protein of unknown function DUF218; KEGG: ecv:APECO1_565 hypothetical protein YP_001176680.1 NAD-linked YP_001176681.1 KEGG: eca:ECA2408 pectin acetylesterase YP_001176682.1 KEGG: ecp:ECP_1421 glyceraldehyde 3-phosphate dehydrogenase C; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase YP_001176683.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm YP_001176684.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain; KEGG: sme:SMa0715 UDP-glucose 4-epimerase YP_001176685.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: mva:Mvan_4266 general substrate transporter YP_001176686.1 PFAM: protein of unknown function DUF156; KEGG: stm:STM1628 cytoplasmic protein YP_001176687.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: stm:STM1627 alcohol dehydrogenase class III YP_001176688.1 PFAM: ligand binding Tar domain protein; histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; KEGG: stm:STM1626 methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor YP_001176689.1 TIGRFAM: TonB family protein YP_001176690.1 PFAM: Pyrrolo-quinoline quinone; KEGG: pfl:PFL_5668 quinate/shikimate dehydrogenase YP_001176691.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: stm:STM1625 transcriptional regulator YP_001176692.1 PFAM: protein of unknown function DUF1338; KEGG: ssn:SSO_1719 hypothetical protein YP_001176693.1 PFAM: Carboxylesterase, type B; KEGG: stm:STM1623 carboxylesterase YP_001176694.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: bur:Bcep18194_B1246 transcriptional regulator, LysR family YP_001176695.1 PFAM: porin, Gram-negative type; KEGG: spt:SPA1382 outer membrane protein YP_001176696.1 catalyzes the transfer of an amino moiety YP_001176697.1 PFAM: extracellular solute-binding protein, family 3; KEGG: bam:Bamb_0110 extracellular solute-binding protein, family 3 YP_001176698.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans YP_001176699.1 KEGG: ecp:ECP_1431 ribosomal-protein-serine acetyltransferase YP_001176700.1 KEGG: stm:STM1610 nucleoside-diphosphate-sugar pyrophosphorylase YP_001176701.1 PFAM: C4-dicarboxylate transporter/malic acid transport protein; KEGG: stm:STM1609 TDT family, K+-tellurite ethidium and proflavin transport protein YP_001176702.1 with TehA confers resistance to tellurite YP_001176703.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_001176704.1 PFAM: extracellular solute-binding protein, family 5; KEGG: eca:ECA2801 periplasmic dipeptide transport protein YP_001176705.1 KEGG: stm:STM1607 outer membrane lipoprotein YP_001176706.1 PFAM: protein of unknown function DUF6, transmembrane; KEGG: aci:ACIAD0161 hypothetical protein YP_001176707.1 PFAM: helix-turn-helix- domain containing protein, AraC type; KEGG: aci:ACIAD0160 transcriptional regulator (AraC family) YP_001176708.1 TIGRFAM: benzoate transporter; PFAM: Benzoate membrane transport protein; Xanthine/uracil/vitamin C permease; KEGG: ecv:APECO1_578 hypothetical protein YP_001176709.1 PFAM: helix-turn-helix domain protein; Cupin 2, conserved barrel domain protein; KEGG: sec:SC1602 oxidoreductase/ repressor YP_001176710.1 PFAM: peptidase U32; KEGG: ecp:ECP_1438 peptidase YP_001176711.1 KEGG: ecp:ECP_1439 hypothetical protein YncJ precursor YP_001176712.1 upregulated by FixLJ/FixK under oxygen limitation; involved in regulation of genes involved in carbon and amino acid metabolism YP_001176713.1 SMART: Rhodanese domain protein; KEGG: ecs:ECs5444 hypothetical protein YP_001176714.1 catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate YP_001176715.1 KEGG: eca:ECA2144 substrate-binding periplasmic transport protein YP_001176716.1 PFAM: inner-membrane translocator; KEGG: yps:YPTB1229 ABC type branched-chain amino acid transporter, permease YP_001176717.1 PFAM: inner-membrane translocator; KEGG: yps:YPTB1230 ABC type branched-chain amino acid transporter, permease YP_001176718.1 PFAM: ABC transporter related; KEGG: eca:ECA2147 ABC transport ATP-binding subunit YP_001176719.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: eca:ECA2148 ABC transport ATP-binding subunit YP_001176720.1 KEGG: stt:t1141 zinc / manganese transport system substrate-binding protein YP_001176721.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters YP_001176722.1 PFAM: protein of unknown function DUF6, transmembrane; Protein of unknown function DUF250; KEGG: ecp:ECP_1519 probable amino acid metabolite efflux pump YP_001176723.1 KEGG: eci:UTI89_C1751 multiple antibiotic resistance protein MarB YP_001176724.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF YP_001176725.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes YP_001176726.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function YP_001176727.1 PFAM: major facilitator superfamily MFS_1; KEGG: stm:STM1522 MFS family, L-arabinose/isopropyl-beta-D-thiogalactopyranoside export protein, contributes to control of arabinose regulon YP_001176728.1 TIGRFAM: phenazine biosynthesis protein PhzF family; PFAM: Phenazine biosynthesis PhzC/PhzF protein; KEGG: pfl:PFL_2667 phenazine biosynthesis protein, PhzF family YP_001176729.1 TIGRFAM: L-lactate dehydrogenase; PFAM: Lactate/malate dehydrogenase; KEGG: lwe:lwe1547 L-lactate dehydrogenase YP_001176730.1 PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc01017 acetyltransferase YP_001176731.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: stt:t1444 regulatory protein YP_001176732.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase YP_001176733.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; KEGG: eca:ECA2317 methyl-accepting chemotaxis protein YP_001176734.1 catalyzes the formation of glutamate from glutamine YP_001176735.1 KEGG: stm:STM1526 cytoplasmic protein YP_001176736.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: sdy:SDY_1629 hypothetical protein YP_001176737.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; MASE2 domain protein; KEGG: aci:ACIAD2279 hypothetical protein YP_001176738.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; GAF domain protein; KEGG: pfo:Pfl_2176 diguanylate cyclase (GGDEF domain) with GAF sensor domain YP_001176739.1 PFAM: GCN5-related N-acetyltransferase; KEGG: bpm:BURPS1710b_3192 acetyltransferase, GNAT family YP_001176740.1 catalyzes the formation of D-tagaturonate from D-altronate YP_001176741.1 PFAM: protein of unknown function UPF0187; KEGG: stm:STM1527 inner membrane protein YP_001176742.1 KEGG: plu:plu1513 hypothetical protein YP_001176743.1 PFAM: GCN5-related N-acetyltransferase; KEGG: psb:Psyr_3814 GCN5-related N-acetyltransferase YP_001176744.1 PFAM: GCN5-related N-acetyltransferase; KEGG: rle:RL0276 acetyltransferase YP_001176745.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate YP_001176746.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least YP_001176747.1 PFAM: porin, LamB type; KEGG: ecp:ECP_2751 sucrose porin precursor YP_001176748.1 TIGRFAM: PTS system, maltose and glucose-specific subfamily, IIC subunit; PTS system, sucrose-specific IIBC subunit; PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS, EIIB protein; phosphotransferase system, EIIC; KEGG: ecp:ECP_2752 PTS system, sucrose-specific IIBC component YP_001176749.1 KEGG: ecp:ECP_2753 sucrose-6-phosphate hydrolase; TIGRFAM: sucrose-6-phosphate hydrolase; PFAM: Glycosyl hydrolase family 32, N terminal domain protein; Glycosyl hydrolase family 32, C-terminal domain protein; SMART: glycoside hydrolase, family 32 YP_001176750.1 TIGRFAM: D-fructose-responsive transcription factor; PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: ecp:ECP_2754 sucrose operon repressor YP_001176751.1 PFAM: Phosphoglycerate mutase; KEGG: eca:ECA3450 hypothetical protein YP_001176752.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: eca:ECA0739 LysR-family transcriptional regulator YP_001176753.1 PFAM: alpha-acetolactate decarboxylase; KEGG: eca:ECA0740 alpha-acetolactate decarboxylase YP_001176754.1 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase YP_001176755.1 TIGRFAM: acetoin reductase; PFAM: short-chain dehydrogenase/reductase SDR; KR; KEGG: eca:ECA0310 acetoin reductase YP_001176756.1 KEGG: eca:ECA2239 hypothetical protein YP_001176757.1 PFAM: protein of unknown function DUF187; KEGG: eca:ECA2240 lipoprotein YP_001176758.1 Involved in disulfide bond formation YP_001176759.1 PFAM: EAL domain protein; BLUF domain protein; KEGG: ecv:APECO1_278 hypothetical protein YP_001176760.1 PFAM: HipA domain protein; KEGG: lpp:lpp0064 HipA protein, DNA binding regulator YP_001176761.1 PFAM: helix-turn-helix domain protein; KEGG: vvu:VV1_0378 predicted transcriptional regulator YP_001176762.1 PFAM: helix-turn-helix, HxlR type; KEGG: pen:PSEEN0576 hypothetical protein YP_001176763.1 PFAM: major facilitator superfamily MFS_1; KEGG: pfl:PFL_3944 major facilitator family transporter YP_001176764.1 KEGG: yps:YPTB3849 hypothetical protein YP_001176765.1 Depolymerizes alginate by cleaving the beta-1,4 glycosidic bond: may enhance the production of alginate by controlling the length of the polymer chain during export YP_001176766.1 PFAM: short-chain dehydrogenase/reductase SDR; KR; KEGG: pfo:Pfl_2439 short-chain dehydrogenase/reductase SDR YP_001176767.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: pfo:Pfl_2438 transcriptional regulator, LysR family YP_001176768.1 PFAM: OsmC family protein; KEGG: sfv:SFV_1739 osmotically inducible protein YP_001176769.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: plu:plu1189 hypothetical protein YP_001176770.1 PFAM: beta-lactamase domain protein; KEGG: aha:AHA_3199 Zn-dependent hydrolase YP_001176771.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: mxa:MXAN_6495 glyoxalase family protein YP_001176772.1 KEGG: stm:STM1564 cytoplasmic protein YP_001176773.1 protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase YP_001176774.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_001176775.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: plu:plu2053 hypothetical protein YP_001176776.1 PFAM: Inorganic pyrophosphatase; KEGG: csa:Csal_2390 inorganic diphosphatase YP_001176777.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers YP_001176778.1 PFAM: protein of unknown function DUF344; KEGG: ppu:PP_0712 hypothetical protein YP_001176779.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase YP_001176780.1 TIGRFAM: formate dehydrogenase, beta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: sbo:SBO_1582 formate dehydrogenase N, nitrate-inducible, iron-sulfur beta subunit YP_001176781.1 KEGG: stm:STM1570 formate dehydrogenase, major subunit (formate dehydrogenase alpha subunit); TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region YP_001176782.1 PFAM: molybdopterin oxidoreductase Fe4S4 region; KEGG: sbo:SBO_1583 formate dehydrogenase N, nitrate-inducible, alpha subunit YP_001176783.1 PFAM: protein of unknown function DUF6, transmembrane; KEGG: ssn:SSO_1651 hypothetical protein YP_001176784.1 PFAM: porin, Gram-negative type; KEGG: ecv:APECO1_972 outer membrane porin protein NmpC precursor YP_001176785.1 PFAM: glutathione-dependent formaldehyde-activating, GFA; KEGG: stm:STM1573.Sc cytoplasmic protein YP_001176786.1 PFAM: major facilitator superfamily MFS_1; KEGG: stm:STM1574 Methyl viologen resistance YP_001176787.1 PFAM: regulatory protein, TetR; KEGG: sec:SC1575 transcriptional regulator, TetR family YP_001176788.1 TIGRFAM: nitrite transporter; PFAM: major facilitator superfamily MFS_1; KEGG: stm:STM1576 MFS superfamily, nitrate extrusion protein YP_001176789.1 TIGRFAM: nitrate reductase, alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; KEGG: stm:STM1577 nitrate reductase alpha chain YP_001176790.1 TIGRFAM: nitrate reductase, beta subunit; KEGG: sec:SC1577 nitrate reductase 2, beta subunit YP_001176791.1 TIGRFAM: nitrate reductase molybdenum cofactor assembly chaperone; PFAM: Nitrate reductase, delta subunit; KEGG: ecs:ECs2069 nitrate reductase delta chain YP_001176792.1 TIGRFAM: respiratory nitrate reductase, gamma subunit; PFAM: Nitrate reductase, gamma subunit; KEGG: ecv:APECO1_602 respiratory nitrate reductase 2 gamma chain YP_001176793.1 PFAM: SpoVT/AbrB domain protein; KEGG: gox:GOX2565 PemI-like protein YP_001176794.1 MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system YP_001176795.1 PFAM: N-acetyltransferase; KEGG: ssn:SSO_1662 N-hydroxyarylamine O-acetyltransferase YP_001176796.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: eca:ECA1345 ABC transporter permease YP_001176797.1 PFAM: extracellular solute-binding protein, family 1; KEGG: eca:ECA1346 ABC transporter substrate binding protein YP_001176798.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: eca:ECA1347 ABC transporter ATP-binding protein YP_001176799.1 PFAM: flavin reductase domain protein, FMN-binding; KEGG: ecv:APECO1_599 hypothetical protein YP_001176800.1 KEGG: sgl:SG1839 hypothetical protein YP_001176801.1 PFAM: small multidrug resistance protein; KEGG: sgl:SG1840 hypothetical protein YP_001176802.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A YP_001176803.1 PFAM: polysaccharide deacetylase; KEGG: sgl:SG1842 hypothetical protein YP_001176804.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains YP_001176805.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate YP_001176806.1 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose YP_001176807.1 KEGG: aha:AHA_2741 hypothetical protein YP_001176808.1 TIGRFAM: translation elongation factor G; small GTP-binding protein; PFAM: elongation factor G domain protein; protein synthesis factor, GTP-binding; elongation factor Tu, domain 2 protein; elongation factor G, domain IV; KEGG: yen:YE0808 elongation factor G YP_001176809.1 SMART: regulatory protein, ArsR; KEGG: bpe:BP2929 regulatory protein YP_001176810.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown YP_001176811.1 PFAM: extracellular solute-binding protein, family 3; KEGG: eca:ECA2157 ABC transporter, substrate binding protein YP_001176812.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: eca:ECA2153 ABC transporter, ATP-binding protein YP_001176813.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: eca:ECA2154 ABC transporter, permease YP_001176814.1 PFAM: GCN5-related N-acetyltransferase; KEGG: eca:ECA2155 acetyltransferase YP_001176815.1 PFAM: extracellular solute-binding protein, family 3; KEGG: eca:ECA2156 ABC transporter, substrate binding protein YP_001176816.1 KEGG: eca:ECA2158 hypothetical protein YP_001176817.1 KEGG: eca:ECA2160 peptidase; TIGRFAM: amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein YP_001176818.1 PFAM: luciferase family protein; KEGG: bch:Bcen2424_6567 luciferase family protein YP_001176819.1 KEGG: eca:ECA2766 hypothetical protein YP_001176820.1 KEGG: eca:ECA3579 methyl-accepting chemotaxis protein; TIGRFAM: PAS sensor protein; PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; PAS fold-3 domain protein; SMART: PAC repeat-containing protein YP_001176821.1 PFAM: Cupin 2, conserved barrel domain protein; KEGG: eca:ECA3135 hypothetical protein YP_001176822.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: eca:ECA3134 LysR-family transcriptional regulator YP_001176823.1 PFAM: amino acid permease-associated region; KEGG: sec:SC1582 APC family, L-asparagine transport protein YP_001176824.1 KEGG: ecv:APECO1_592 hypothetical protein YP_001176825.1 TIGRFAM: TonB-dependent siderophore receptor; PFAM: TonB-dependent receptor; TonB-dependent receptor, plug; KEGG: ecv:APECO1_591 predicted iron outer membrane transporter YP_001176826.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; KEGG: eca:ECA2579 methyl-accepting chemotaxis citrate transducer YP_001176827.1 PFAM: regulatory protein GntR, HTH; KEGG: stm:STM1588 regulatory protein YP_001176828.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; KEGG: spt:SPA1279 NADP-dependent oxidoreductase YP_001176829.1 PFAM: helix-turn-helix domain protein; KEGG: reu:Reut_B5130 helix-turn-helix motif YP_001176830.1 PFAM: GCN5-related N-acetyltransferase; KEGG: ecj:JW5233 predicted acyltransferase with acyl-CoA N-acyltransferase domain YP_001176831.1 PFAM: protein of unknown function DUF606; KEGG: ecv:APECO1_588 hypothetical protein YP_001176832.1 KEGG: sbo:SBO_1602 hypothetical protein YP_001176833.1 PFAM: extracellular solute-binding protein, family 5; KEGG: pmu:PM0236 dipeptide transport protein, periplasmic YP_001176834.1 KEGG: sec:SC1590 ssrAB activated gene YP_001176835.1 PFAM: virulence protein SrfB; KEGG: sec:SC1591 ssrAB activated gene YP_001176836.1 KEGG: stm:STM1595 virulence protein YP_001176837.1 PFAM: Endoribonuclease L-PSP; KEGG: pae:PA0814 hypothetical protein YP_001176838.1 KEGG: eca:ECA3125 hypothetical protein YP_001176839.1 catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate YP_001176840.1 KEGG: ecc:c0945 hypothetical protein YP_001176841.1 PFAM: glycoside hydrolase, family 28; KEGG: eca:ECA1190 polygalacturonase YP_001176842.1 KEGG: xac:XAC3635 hypothetical protein YP_001176843.1 KEGG: ecs:ECs0310 hypothetical protein YP_001176844.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: ecs:ECs0309 transcriptional regulator YP_001176845.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; KEGG: ajs:Ajs_0160 methyl-accepting chemotaxis sensory transducer YP_001176846.1 KEGG: sdy:SDY_1729 hypothetical protein YP_001176847.1 KEGG: sdy:SDY_1697 hypothetical protein YP_001176848.1 KEGG: sdy:SDY_1697 hypothetical protein YP_001176849.1 KEGG: stm:STM1272 cytoplasmic protein YP_001176850.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation YP_001176851.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ecv:APECO1_585 transport system permease YP_001176852.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ecp:ECP_1444 binding-protein-dependent transport system inner membrane component YP_001176853.1 PFAM: ABC transporter related; TOBE domain protein; Transport-associated OB domain protein; SMART: AAA ATPase; KEGG: ssn:SSO_1696 ATP-binding component of a transport system YP_001176854.1 PFAM: extracellular solute-binding protein, family 1; KEGG: ecj:JW1435 predicted spermidine/putrescine transporter subunit YP_001176855.1 PFAM: regulatory protein GntR, HTH; aminotransferase, class I and II; KEGG: sec:SC1595 regulatory protein, GntR family YP_001176856.1 KEGG: sec:SC1999 cold-shock protein YP_001176857.1 PFAM: cytochrome bd ubiquinol oxidase, subunit I; KEGG: stm:STM0360 cytochrome BD2 subunit I YP_001176858.1 TIGRFAM: cytochrome d ubiquinol oxidase, subunit II; PFAM: cytochrome bd ubiquinol oxidase, subunit II; KEGG: stm:STM0361 cytochrome BD2 subunit II YP_001176859.1 KEGG: pfl:PFL_5362 hypothetical protein YP_001176860.1 PFAM: protein of unknown function DUF306, Meta and HslJ; KEGG: ecp:ECP_1405 hypothetical protein YP_001176861.1 KEGG: sec:SC1644 cytoplasmic protein YP_001176862.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: ecp:ECP_1403 probable pyruvate-flavodoxin oxidoreductase YP_001176863.1 KEGG: yps:YPTB2343 hypothetical protein YP_001176864.1 PFAM: glutathione-dependent formaldehyde-activating, GFA; KEGG: spt:SPA1243 hypothetical protein YP_001176865.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; KEGG: bpe:BP1030 methyl-accepting chemotaxis protein I YP_001176866.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; GAF domain protein; KEGG: pin:Ping_1699 fused adenylate cyclase and hybrid sensor diguanylate cyclase and response regulator YP_001176867.1 KEGG: sbo:SBO_1716 transposase YP_001176868.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_001176869.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA YP_001176870.1 PFAM: Mg2+ transporter protein, CorA family protein; KEGG: stm:STM1656 Zn transport protein YP_001176871.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; KEGG: stm:STM1657 methyl-accepting chemotaxis protein YP_001176872.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; MHYT domain protein; KEGG: pae:PA1727 hypothetical protein YP_001176873.1 KEGG: sbo:SBO_1720 hypothetical protein; TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; PAS fold-3 domain protein; PAS fold-4 domain protein; SMART: PAS domain containing protein YP_001176874.1 PFAM: extracellular solute-binding protein, family 5; KEGG: ssn:SSO_1804 transport periplasmic protein YP_001176875.1 PFAM: peptidase M14, carboxypeptidase A; KEGG: sbo:SBO_1744 carboxypeptidase YP_001176876.1 PFAM: Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein; Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein; KEGG: sdy:SDY_1403 muconate cycloisomerase I YP_001176877.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein YP_001176878.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids YP_001176879.1 PFAM: conserved hypothetical protein 1620; KEGG: ecs:ECs1901 hypothetical protein YP_001176880.1 PFAM: protein of unknown function DUF463, YcjX family protein; KEGG: sdy:SDY_1399 YcjX YP_001176881.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: ecs:ECs1899 LacI-type transcriptional regulator YP_001176882.1 KEGG: ecp:ECP_1372 outer membrane protein G precursor YP_001176883.1 KEGG: ecv:APECO1_471 hypothetical ABC transporter ATP-binding protein YcjV; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; beta-phosphoglucomutase; beta-phosphoglucomutase family hydrolase; PFAM: ABC transporter related; Haloacid dehalogenase domain protein hydrolase; Transport-associated OB domain protein; SMART: AAA ATPase YP_001176884.1 PFAM: glycoside hydrolase, family 65 domain protein; glycoside hydrolase family 65, central catalytic; glycoside hydrolase family 65 domain protein; KEGG: ecj:JW1309 predicted hydrolase YP_001176885.1 PFAM: oxidoreductase domain protein; Oxidoreductase, C-terminal domain; KEGG: ecj:JW1308 predicted oxidoreductase, NADH-binding YP_001176886.1 PFAM: Xylose isomerase domain protein TIM barrel; KEGG: ecv:APECO1_467 transient receptor potential locus YP_001176887.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; KEGG: sfv:SFV_1329 oxidoreductase YP_001176888.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ecp:ECP_1364 binding-protein-dependent transport system inner membrane component YP_001176889.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ecv:APECO1_464 binding-protein dependent transport protein YP_001176890.1 PFAM: extracellular solute-binding protein, family 1; KEGG: ecj:JW1303 predicted sugar transporter subunit YP_001176891.1 PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain; KEGG: ece:Z2475m glycosidase YP_001176892.1 KEGG: ecc:c1778 phage shock protein D YP_001176893.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock YP_001176894.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding YP_001176895.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF YP_001176896.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor YP_001176897.1 PFAM: extracellular solute-binding protein, family 5; KEGG: sec:SC1685 ABC superfamily (periplasm), peptide transport protein YP_001176898.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: spt:SPA1191 peptide transport system permease SapB YP_001176899.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: sfv:SFV_1306 peptide transport permease YP_001176900.1 KEGG: spt:SPA1181 peptide transport system ATP-binding protein SapD; TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001176901.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: sbo:SBO_1772 ATP-binding protein of peptide transport system YP_001176902.1 KEGG: ecv:APECO1_1633 hypothetical protein YP_001176903.1 KEGG: stt:t4635 transcriptional regulator protein YP_001176904.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_001176905.1 KEGG: ecs:ECs1860 oxidoreductase YP_001176906.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction YP_001176907.1 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP YP_001176908.1 regulator of pathogenicity factor RpfF; involved in synthesis of a diffusible signal factor involved in the regulation of extracellular enzymes YP_001176909.1 KEGG: sec:SC1698 hypothetical protein YP_001176910.1 PFAM: regulatory protein, DeoR; Helix-turn-helix, type 11 domain protein; KEGG: spt:SPA1172 regulatory protein YP_001176912.1 involved in start site selection during the initiation of translation YP_001176913.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_001176914.1 SMART: Tetratricopeptide domain protein; KEGG: stm:STM1708 N-acetylglucosaminyl transferase YP_001176915.1 PFAM: protein of unknown function DUF1049; KEGG: sbo:SBO_1785 hypothetical protein YP_001176916.1 PFAM: phosphoesterase, PA-phosphatase related; KEGG: stm:STM1710 phosphatidylglycerophosphatase B YP_001176917.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate YP_001176918.1 Catalyzes the conversion of citrate to isocitrate YP_001176919.1 KEGG: eci:UTI89_C1546 hypothetical protein YP_001176920.1 KEGG: sdy:SDY_1348 hypothetical protein YP_001176921.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation YP_001176922.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_001176923.1 KEGG: stm:STM1715 cytoplasmic protein YP_001176924.1 SohB; periplasmic protein; member of the peptidase S49 family YP_001176925.1 PFAM: short-chain dehydrogenase/reductase SDR; KR; KEGG: ecj:JW1263 predicted oxoacyl-(acyl carrier protein) reductase, EmrKY-TolC system YP_001176926.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_001176927.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA YP_001176928.1 TIGRFAM: Sua5/YciO/YrdC/YwlC family protein; PFAM: SUA5/yciO/yrdC, N-terminal domain; KEGG: sbo:SBO_1799 hypothetical protein YP_001176929.1 PFAM: PHP C-terminal domain protein; SMART: phosphoesterase PHP domain protein; KEGG: ecj:JW1258 conserved hypothetical protein YP_001176930.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_001176931.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis YP_001176932.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate YP_001176933.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001176934.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_001176935.1 KEGG: stm:STM1053 hypothetical protein YP_001176936.1 KEGG: stm:STM1053 hypothetical protein YP_001176937.1 PFAM: SEC-C motif domain protein; KEGG: pcr:Pcryo_2158 hypothetical protein YP_001176938.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization YP_001176939.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization YP_001176940.1 KEGG: pau:PA14_59220 pyocin S5 YP_001176941.1 KEGG: sgl:SG1235 hypothetical protein YP_001176944.1 PFAM: Fibronectin, type III domain protein; KEGG: ypn:YPN_1600 phage host specificity protein YP_001176945.1 PFAM: bacteriophage lambda tail assembly I; KEGG: ypn:YPN_1599 phage tail assembly protein YP_001176946.1 PFAM: NLP/P60 protein; SMART: Mov34/MPN/PAD-1 family protein; KEGG: ypn:YPN_1594 phage minor tail protein YP_001176947.1 PFAM: phage minor tail protein L; KEGG: ypn:YPN_1593 hypothetical protein YP_001176948.1 PFAM: phage minor tail family protein; KEGG: pen:PSEEN4178 prophage LambdaSo, minor tail protein M YP_001176949.1 TIGRFAM: phage tail tape measure protein, lambda family; phage tape measure protein; KEGG: ecv:APECO1_6007 phage-related minor tail protein YP_001176950.1 KEGG: ecv:APECO1_4212 hypothetical protein YP_001176951.1 KEGG: ecs:ECs2241 tail protein YP_001176952.1 PFAM: phage tail assembly chaperone; KEGG: ecv:APECO1_1016 tail assembly chaperone YP_001176953.1 KEGG: ecv:APECO1_1017 phage major tail subunit YP_001176954.1 KEGG: ecs:ECs1979 hypothetical protein YP_001176955.1 TIGRFAM: phage protein, HK97 gp10 family; PFAM: TP901-1 ORF40 family protein; KEGG: ecv:APECO1_1019 hypothetical protein YP_001176956.1 PFAM: phage head-tail adaptor, KEGG: ecv:APECO1_1020 head-tail adaptor YP_001176957.1 KEGG: ecs:ECs1545 hypothetical protein YP_001176958.1 KEGG: ecs:ECs1975 hypothetical protein YP_001176959.1 TIGRFAM: phage portal protein, HK97 family; PFAM: phage portal protein; KEGG: ecs:ECs1974 portal protein YP_001176960.1 KEGG: ecs:ECs5451 hypothetical protein YP_001176961.1 PFAM: peptidase U35, phage prohead HK97; KEGG: ecs:ECs2250 major head protein/prohead protease YP_001176962.1 PFAM: phage Terminase; KEGG: bte:BTH_II1044 phage terminase, large subunit YP_001176963.1 KEGG: ece:Z1802 unknown protein encoded by prophage CP-933N YP_001176964.1 PFAM: HNH endonuclease; KEGG: ece:Z1800 unknown protein encoded by prophage CP-933N YP_001176968.1 KEGG: psb:Psyr_3494 hypothetical protein YP_001176970.1 PFAM: bacteriophage lysis protein; KEGG: sfv:SFV_2707 endopeptidase YP_001176971.1 PFAM: glycoside hydrolase, family 24; KEGG: ecs:ECs2968 endolysin YP_001176972.1 PFAM: Lysis S family protein; KEGG: ecs:ECs3497 holin protein YP_001176973.1 PFAM: DNA methylase N-4/N-6 domain protein; KEGG: eci:UTI89_C5110 hypothetical protein YP_001176974.1 KEGG: ecs:ECs1779 hypothetical lipoprotein YP_001176976.1 PFAM: protein of unknown function DUF1277; SMART: HNH nuclease; KEGG: eci:UTI89_C5106 hypothetical protein YdfU YP_001176977.1 PFAM: endodeoxyribonuclease RusA; KEGG: saa:SAUSA300_1955 endodeoxyribonuclease RusA YP_001176978.1 PFAM: DinI family protein; KEGG: sec:SC2624 Gifsy-1 prophage DinI YP_001176979.1 KEGG: yps:YPTB1799 modification methylase YP_001176980.1 KEGG: stm:PSLT064 inner membrane protein YP_001176981.1 PFAM: protein of unknown function DUF977; KEGG: stt:t1916 DNA-binding protein YP_001176983.1 KEGG: ecs:ECs2762 phage replication protein YP_001176984.1 KEGG: ecs:ECs2206 hypothetical protein YP_001176985.1 KEGG: ecp:ECP_1148 bacteriophage regulatory protein CII YP_001176986.1 PFAM: helix-turn-helix domain protein; KEGG: sec:SC2634 DNA-binding protein YP_001176987.1 PFAM: Exonuclease, RNase T and DNA polymerase III; KEGG: sbo:SBO_0976 exodeoxyribonuclease VIII YP_001176988.1 KEGG: ecc:c1401 excisionase for prophage YP_001176989.1 PFAM: phage integrase family protein; KEGG: ecs:ECs1501 integrase YP_001176990.1 PFAM: protein of unknown function DUF395, YeeE/YedE; KEGG: sbo:SBO_1077 transport system permease YP_001176991.1 PFAM: SirA family protein; KEGG: sdy:SDY_1085 hypothetical protein YP_001176992.1 PFAM: phosphotransferase system, lactose/cellobiose-specific IIB subunit; KEGG: vch:VC1281 PTS system, cellobiose-specific IIB component YP_001176993.1 PFAM: GCN5-related N-acetyltransferase; KEGG: lpn:lpg2171 hypothetical protein YP_001176994.1 PFAM: Rhodanese domain protein; KEGG: stt:t2693 hypothetical protein YP_001176995.1 PFAM: regulatory protein, ArsR; KEGG: stm:STM2797 regulatory protein YP_001176996.1 PFAM: regulatory protein, TetR; KEGG: ajs:Ajs_2168 transcriptional regulator, TetR family YP_001176997.1 PFAM: NADH:flavin oxidoreductase/NADH oxidase; KEGG: bam:Bamb_4736 NADH:flavin oxidoreductase/NADH oxidase YP_001176998.1 PFAM: short-chain dehydrogenase/reductase SDR; KR; KEGG: bam:Bamb_4735 short-chain dehydrogenase/reductase SDR YP_001176999.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR; KEGG: pol:Bpro_0106 short-chain dehydrogenase/reductase SDR YP_001177000.1 KEGG: pol:Bpro_0104 hypothetical protein YP_001177001.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: ppu:PP_2988 alcohol dehydrogenase, zinc-containing YP_001177002.1 PFAM: protein of unknown function DUF1440; KEGG: ecs:ECs0317 hypothetical protein YP_001177003.1 receptor for colicin S4 YP_001177004.1 PFAM: protein of unknown function UPF0259; KEGG: stm:STM1734 hypothetical protein YP_001177005.1 Involved in cell division; probably involved in intracellular septation YP_001177006.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins YP_001177007.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins YP_001177008.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_001177009.1 PFAM: Ketopantoate reductase ApbA/PanE, N-terminal domain protein; Ketopantoate reductase ApbA/PanE, C-terminal domain protein; KEGG: eca:ECA1579 probable ketopantoate reductase YP_001177010.1 PFAM: protein of unknown function DUF6, transmembrane; KEGG: bxe:Bxe_A3474 10 TMS drug/metabolite exporter, DME family, DMT superfamily YP_001177011.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: bpm:BURPS1710b_0623 glycine cleavage system transcriptional activator YP_001177012.1 KEGG: eca:ECA0938 hypothetical protein YP_001177013.1 PFAM: Lysine exporter protein (LYSE/YGGA); KEGG: sdy:SDY_1698 hypothetical protein YP_001177014.1 KEGG: ecv:APECO1_365 hypothetical protein YP_001177015.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) YP_001177016.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein YP_001177017.1 PFAM: Ion transport protein; Ion transport 2 domain protein,; KEGG: stm:STM1741 voltage-gated potassium channel YP_001177018.1 KEGG: sty:STY1309 oligopeptide transport ATP-binding protein OppF; TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001177019.1 KEGG: ssn:SSO_1934 ATP-binding protein of oligopeptide ABC transport system; TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001177020.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: stm:STM1744 ABC superfamily (membrane), oligopeptide transport protein YP_001177021.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: stm:STM1745 ABC superfamily (membrane), oligopeptide transport protein YP_001177022.1 PFAM: extracellular solute-binding protein, family 5; KEGG: ecc:c1707 periplasmic oligopeptide-binding protein precursor YP_001177023.1 PFAM: multiple antibiotic resistance (MarC)-related protein; KEGG: stm:STM1748 integral membrane protein YP_001177024.1 PFAM: iron-containing alcohol dehydrogenase; aldehyde dehydrogenase; KEGG: sfv:SFV_1253 CoA-linked acetaldehyde dehydrogenase and iron-dependent alcohol dehydrogenase YP_001177025.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_001177026.1 PFAM: histone family protein nucleoid-structuring protein H-NS; KEGG: stm:STM1751 DNA-binding protein HLP-II (HU, BH2, HD, NS); pleiotropic regulator YP_001177027.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose YP_001177028.1 PFAM: response regulator receiver; KEGG: stm:STM1753 response regulator YP_001177029.1 PFAM: Patatin; KEGG: ecv:APECO1_348 hypothetical protein YP_001177030.1 PFAM: SEC-C motif domain protein; KEGG: sdy:SDY_1285 hypothetical protein YP_001177031.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_001177032.1 TIGRFAM: respiratory nitrate reductase, gamma subunit; PFAM: Nitrate reductase, gamma subunit; KEGG: stm:STM1761 nitrate reductase gamma chain YP_001177033.1 TIGRFAM: nitrate reductase molybdenum cofactor assembly chaperone; PFAM: Nitrate reductase, delta subunit; KEGG: stm:STM1762 nitrate reductase delta chain YP_001177034.1 TIGRFAM: nitrate reductase, beta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: sec:SC1757 nitrate reductase 1, FeS (beta) subunit YP_001177035.1 TIGRFAM: nitrate reductase, alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; KEGG: ecv:APECO1_341 nitrate reductase 1, alpha subunit YP_001177036.1 TIGRFAM: nitrite transporter; PFAM: major facilitator superfamily MFS_1; KEGG: sec:SC1759 MFS superfamily, nitrite extrusion protein YP_001177037.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase, dimerisation and phosphoacceptor region; KEGG: stm:STM1766 two-component system, NarL family, sensor kinase YP_001177038.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase YP_001177039.1 KEGG: sec:SC1762 invasin YP_001177040.1 PFAM: Integrase, catalytic region; KEGG: rpe:RPE_1052 integrase, catalytic region YP_001177041.1 PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; BFD domain protein [2Fe-2S]-binding domain protein; KEGG: eca:ECA2990 nitrate reductase YP_001177042.1 TIGRFAM: nitrite reductase [NAD(P)H], large subunit; nitrite reductase [NAD(P)H], small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; BFD domain protein [2Fe-2S]-binding domain protein; KEGG: eca:ECA2991 nitrite reductase [NAD(P)H] large subunit YP_001177043.1 KEGG: eca:ECA2992 nitrate transport protein; TIGRFAM: nitrate ABC transporter, ATPase subunits C and D; PFAM: ABC transporter related; SMART: AAA ATPase YP_001177044.1 TIGRFAM: nitrate ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: eca:ECA2993 nitrate transporter permease component YP_001177045.1 KEGG: eca:ECA2994 nitrate-binding proteint YP_001177046.1 PFAM: ANTAR domain protein; Nitrate and nitrite sensing domain protein; KEGG: eca:ECA2995 nitrate-and nitrite-responsive positive regulator YP_001177047.1 PFAM: DsrE family protein; KEGG: stm:STM1769 ACR involved in intracellular sulfur reduction YP_001177048.1 PFAM: histidine kinase, HAMP region domain protein; Cache domain protein; chemotaxis sensory transducer; KEGG: bte:BTH_I3209 methyl-accepting chemotaxis protein YP_001177049.1 KEGG: eca:ECA2434 hypothetical protein YP_001177050.1 PFAM: ChaC family protein; KEGG: ecv:APECO1_335 cation transport protein ChaC YP_001177051.1 in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions YP_001177052.1 TIGRFAM: calcium/proton exchanger; PFAM: sodium/calcium exchanger membrane region; KEGG: ecp:ECP_1265 CacA family, sodium-calcium/proton antiporter YP_001177053.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_001177054.1 KEGG: stm:STM1773 transcriptional regulator YP_001177055.1 PFAM: Invasion gene expression up-regulator, SirB; KEGG: stm:STM1774 Regulation of invasion genes YP_001177056.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB YP_001177057.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001177058.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_001177059.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein YP_001177060.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_001177061.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_001177062.1 role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport YP_001177063.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function YP_001177064.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001177065.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001177066.1 PFAM: Cupin 2, conserved barrel domain protein; KEGG: ccr:CC3157 hypothetical protein YP_001177067.1 KEGG: bch:Bcen2424_6422 oxidoreductase alpha (molybdopterin) subunit; TIGRFAM: oxidoreductase alpha (molybdopterin) subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region YP_001177068.1 PFAM: helix-turn-helix- domain containing protein, AraC type; AraC protein, arabinose-binding/dimerisation; KEGG: hch:HCH_00877 AraC-type DNA-binding domain-containing protein YP_001177069.1 PFAM: AzlC family protein; KEGG: bce:BC1674 branched-chain amino acid transport protein AzlC YP_001177070.1 PFAM: branched-chain amino acid transport; KEGG: mta:Moth_1242 branched-chain amino acid transport YP_001177071.1 KEGG: bxe:Bxe_B0964 ABC phosphate/phosphonate transporter, periplasmic ligand binding protein YP_001177072.1 PFAM: fatty acid desaturase; KEGG: bxe:Bxe_B1009 fatty acid desaturase YP_001177073.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: bch:Bcen2424_3560 major facilitator superfamily MFS_1 YP_001177074.1 PFAM: helix-turn-helix- domain containing protein, AraC type; KEGG: bam:Bamb_5293 transcriptional regulator, AraC family YP_001177075.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell YP_001177076.1 TIGRFAM: TonB-dependent siderophore receptor; PFAM: TonB-dependent receptor; TonB-dependent receptor, plug; KEGG: vvu:VV2_1337 outer membrane receptor protein YP_001177077.1 PFAM: Transglycosylase-associated protein; KEGG: stm:STM1797 transglycosylase-associated protein YP_001177078.1 PFAM: type IV pilus assembly PilZ; YcgR family protein; KEGG: stm:STM1798 inner membrane protein YP_001177079.1 PFAM: Lytic transglycosylase, catalytic; KEGG: stm:STM1799 membrane-bound lytic murein transglycosylase E YP_001177080.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine YP_001177081.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli YP_001177082.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA YP_001177083.1 catalyzes the oxidative deamination of D-amino acids YP_001177084.1 PFAM: SpoVR family protein; KEGG: ecv:APECO1_300 hypothetical protein YP_001177085.1 Multifunctional regulator of fatty acid metabolism YP_001177086.1 involved in regulation of intracellular pH under alkaline conditions YP_001177087.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein YP_001177088.1 PFAM: protein of unknown function UPF0153; KEGG: ecv:APECO1_294 hypothetical protein YP_001177089.1 PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: ecj:JW1169 predicted isomerase/hydrolase YP_001177090.1 PFAM: protein of unknown function DUF709; KEGG: stm:STM1813 cytoplasmic protein YP_001177091.1 blocks the formation of polar Z-ring septums YP_001177092.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums YP_001177093.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell YP_001177094.1 TIGRFAM: ribonuclease D; PFAM: HRDC domain protein; 3'-5' exonuclease; KEGG: sec:SC1810 RNase D, processes tRNA precursor YP_001177095.1 Activates fatty acids by binding to coenzyme A YP_001177096.1 TIGRFAM: outer membrane lipoprotein, Slp family; PFAM: outer membrane lipoprotein Slp; KEGG: ecs:ECs2515 outer membrane protein YP_001177097.1 PFAM: peptidase M22, glycoprotease; KEGG: stm:STM1820 molecular chaperone YP_001177098.1 SMART: helicase c2; DEAD-like helicases-like; KEGG: stm:STM1821 DNA helicase YP_001177099.1 PFAM: Endoribonuclease L-PSP; KEGG: sdy:SDY_1713 hypothetical protein YP_001177100.1 PFAM: protein of unknown function UPF0181; KEGG: stm:STM1823 cytoplasmic protein YP_001177101.1 TIGRFAM: para-aminobenzoate synthase, subunit I; PFAM: Anthranilate synthase component I and chorismate binding protein; Anthranilate synthase component I domain protein; KEGG: ecv:APECO1_869 para-aminobenzoate synthase component I YP_001177102.1 PFAM: NUDIX hydrolase; KEGG: sdy:SDY_1719 hypothetical protein YP_001177103.1 KEGG: stm:STM1826 L-serine deaminase I/L-threonine deaminase I; TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain YP_001177104.1 PFAM: EAL domain protein; KEGG: spt:SPA1046 hypothetical protein YP_001177105.1 PFAM: CBS domain containing protein; transporter-associated region; Integral membrane protein TerC; KEGG: spt:SPA1045 hypothetical protein YP_001177106.1 TIGRFAM: PTS system, mannose/fructose/sorbose family, IIB subunit; PTS system, mannose/fructose/sorbose family, IIA subunit; PFAM: PTS system fructose subfamily IIA component; PTS system sorbose subfamily IIB component; KEGG: sbo:SBO_1229 PTS enzyme IIAB, mannose-specific YP_001177107.1 TIGRFAM: PTS system, mannose/fructose/sorbose family, IIC subunit; PFAM: phosphotransferase system PTS, sorbose-specific IIC subunit; KEGG: stm:STM1831 Sugar Specific PTS family, mannose-specific enzyme IIC YP_001177108.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel YP_001177109.1 PFAM: protein of unknown function DUF986; KEGG: sdy:SDY_1966 hypothetical protein YP_001177110.1 PFAM: protein of unknown function DUF204; KEGG: ecv:APECO1_878 conserved inner membrane protein YP_001177111.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth YP_001177112.1 PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain; KEGG: stm:STM1836 penicillin-binding protein 3 YP_001177113.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein; KEGG: sdy:SDY_1969 cold shock protein YP_001177114.1 KEGG: sbo:SBO_1238 hypothetical protein YP_001177115.1 KEGG: sdy:SDY_1973 hypothetical protein YP_001177116.1 KEGG: sdy:SDY_1974 hypothetical protein YP_001177117.1 PFAM: regulatory protein, IclR; KEGG: stm:STM1842 transcriptional repressor YP_001177118.1 PFAM: major facilitator superfamily MFS_1; KEGG: sec:SC1839 transport protein YP_001177119.1 metalloprotease YP_001177120.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 YP_001177121.1 affects solute and DNA transport through an unknown mechanism YP_001177122.1 PFAM: GAF domain protein; KEGG: sdy:SDY_1980 hypothetical protein YP_001177123.1 TIGRFAM: integral membrane protein, PqiA family; PFAM: Paraquat-inducible protein A; KEGG: stm:STM1848 inner membrane protein YP_001177124.1 PFAM: Mammalian cell entry related domain protein; KEGG: ecp:ECP_1778 hypothetical protein YebT ( membrane protein) YP_001177125.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA YP_001177126.1 PFAM: protein of unknown function DUF1480; KEGG: sec:SC1847 cytoplasmic protein YP_001177127.1 PFAM: protein of unknown function DUF1482; KEGG: ssn:SSO_1324 hypothetical protein YP_001177128.1 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins YP_001177129.1 PFAM: protein of unknown function DUF535; KEGG: spt:SPA1859 VirK protein YP_001177130.1 KEGG: ecs:ECs2549 hypothetical protein YP_001177131.1 PFAM: copper resistance D domain protein; KEGG: stm:STM1874 inner membrane protein YP_001177132.1 PFAM: copper resistance protein CopC; KEGG: stm:STM1875 homolog of Cu resistance protein CopC YP_001177133.1 PFAM: DNA polymerase II, beta subunit; KEGG: stm:STM1876 DNA polymerase III, theta subunit YP_001177134.1 PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: sec:SC1882 amidohydrolase YP_001177135.1 3'-5' exonuclease activity on single or double-strand DNA YP_001177136.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues YP_001177137.1 PFAM: protein of unknown function DUF533; KEGG: sec:SC1885 inner membrane protein YP_001177138.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_001177139.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_001177140.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_001177141.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001177142.1 Represses the expression of the zwf, eda, glp and gap YP_001177143.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001177144.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA YP_001177145.1 PFAM: Peptidoglycan-binding LysM; peptidase M23B; Opacity-associated protein A; Opacity-associated protein A, N-terminal domain protein; KEGG: stm:STM1890 peptidase YP_001177146.1 involved in transport of zinc(II) with ZnuA and C YP_001177147.1 involved in transport of zinc(II) with ZnuA and C YP_001177148.1 involved in transport of zinc(II) with ZnuA and C YP_001177149.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001177150.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001177151.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001177152.1 PFAM: protein of unknown function DUF28; KEGG: ecv:APECO1_914 hypothetical protein YP_001177153.1 converts dATP to dAMP and pyrophosphate YP_001177154.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001177155.1 PFAM: isochorismatase hydrolase; KEGG: stm:STM1902 isochorismatase YP_001177156.1 PFAM: protein of unknown function DUF72; KEGG: ecj:JW1857 conserved hypothetical protein YP_001177157.1 KEGG: stm:STM1904 inner membrane protein YP_001177158.1 TIGRFAM: methyltransferase; PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: sdy:SDY_1169 hypothetical protein YP_001177159.1 TIGRFAM: methyltransferase; PFAM: methyltransferase, ; Methyltransferase type 11; KEGG: sec:SC1914 enzyme YP_001177160.1 PFAM: CutC family protein; KEGG: sbo:SBO_1126 copper homeostasis protein YP_001177161.1 PFAM: protein of unknown function DUF991; KEGG: sec:SC1915 cytoplasmic protein YP_001177162.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001177163.1 PFAM: glycosyl hydrolase, family 88; KEGG: stm:STM1911 cytoplasmic protein YP_001177164.1 PFAM: major facilitator superfamily MFS_1; KEGG: eca:ECA3560 oligogalacturonide transporter YP_001177165.1 PFAM: flagellar FlhE family protein; KEGG: spt:SPA0956 flagellar protein FlhE precursor YP_001177166.1 membrane protein involved in the flagellar export apparatus YP_001177167.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_001177168.1 PFAM: Fimbrial protein; KEGG: bur:Bcep18194_A4771 fimbrial protein YP_001177169.1 PFAM: pili assembly chaperone; KEGG: sfx:S3397 chaperone YP_001177170.1 PFAM: fimbrial biogenesis outer membrane usher protein; KEGG: ecs:ECs4022 outer membrane protein YP_001177171.1 PFAM: Fimbrial protein; KEGG: sfv:SFV_3175 fimbrial protein YP_001177172.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation YP_001177173.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble YP_001177174.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_001177175.1 methylates the MCP YP_001177176.1 mediates taxis toward dipeptides YP_001177177.1 PFAM: ligand binding Tar domain protein; histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; KEGG: sec:SC1926 methyl accepting chemotaxis protein II, aspartate sensor-receptor YP_001177178.1 PFAM: Spore coat U domain protein; KEGG: pen:PSEEN3394 type 1 pili protein CsuE YP_001177179.1 PFAM: fimbrial biogenesis outer membrane usher protein; KEGG: pfo:Pfl_3669 fimbrial biogenesis outer membrane usher protein YP_001177180.1 KEGG: pen:PSEEN3396 type 1 pili usher pathway chaperone CsuC YP_001177181.1 PFAM: Spore coat U domain protein; KEGG: pfo:Pfl_3671 spore coat U YP_001177182.1 PFAM: Spore coat U domain protein; KEGG: sgl:SG1528 hypothetical protein YP_001177183.1 PFAM: sodium:dicarboxylate symporter; KEGG: aha:AHA_2605 proton/sodium-glutamate symport protein YP_001177184.1 PFAM: Integrase, catalytic region; KEGG: rpe:RPE_1052 integrase, catalytic region YP_001177185.1 PFAM: CheW domain protein; KEGG: stm:STM1920 purine-binding chemotaxis protein; regulation YP_001177186.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component YP_001177187.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_001177188.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_001177189.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems YP_001177190.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems YP_001177191.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress YP_001177192.1 KEGG: stm:STM1928 trehalose-6-phosphate synthase; TIGRFAM: alpha,alpha-trehalose-phosphate synthase [UDP-forming]; PFAM: glycosyl transferase, family 20 YP_001177193.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature YP_001177194.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_001177195.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_001177196.1 PFAM: periplasmic binding protein/LacI transcriptional regulator; KEGG: ecj:JW1889 L-arabinose transporter subunit YP_001177197.1 PFAM: ThiJ/PfpI domain protein; KEGG: stm:STM1931 intracellular protease/amidase YP_001177198.1 PFAM: Ferritin, Dps family protein; KEGG: stm:STM1932 ferritin-like protein YP_001177199.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters YP_001177200.1 KEGG: sdy:SDY_1117 hypothetical protein YP_001177201.1 KEGG: ecc:c2318 hypothetical protein YP_001177202.1 PFAM: major facilitator superfamily MFS_1; KEGG: rru:Rru_A3056 major facilitator superfamily MFS_1 YP_001177203.1 PFAM: Ribose/galactose isomerase; KEGG: stm:STM1933 hypothetical protein YP_001177204.1 PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: extracellular solute-binding protein, family 3; metal-dependent phosphohydrolase, HD region; KEGG: vfi:VF1367 two-component response regulator YP_001177205.1 KEGG: spt:SPA0935 lipoprotein YP_001177206.1 cytoplasmic iron storage protein YP_001177207.1 KEGG: stm:STM1936 cytoplasmic protein YP_001177208.1 KEGG: msu:MS1456 hypothetical protein YP_001177209.1 TIGRFAM: aromatic amino acid transporter; PFAM: aromatic amino acid permease; Amino acid transporter, transmembrane; KEGG: ecv:APECO1_952 tyrosine-specific transport system YP_001177210.1 TIGRFAM: yecA family protein; PFAM: SEC-C motif domain protein; KEGG: sbo:SBO_1098 hypothetical protein YP_001177211.1 PFAM: Extracellular ligand-binding receptor; KEGG: pau:PA14_64900 binding protein component of ABC transporter YP_001177212.1 PFAM: inner-membrane translocator; KEGG: pst:PSPTO_4918 high-affinity branched-chain amino acid ABC transporter, permease BraD YP_001177213.1 PFAM: inner-membrane translocator; KEGG: ppu:PP_4865 branched-chain amino acid ABC transporter, permease YP_001177214.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: pau:PA14_64870 branched-chain amino acid ABC transporter, ATP-binding protein YP_001177215.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: pau:PA14_64860 ranched-chain amino acid ABC transporter, ATP-binding protein YP_001177216.1 KEGG: ecj:JW1369 predicted DNA-binding transcriptional regulator YP_001177217.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein; KEGG: ecj:JW1549 cold shock protein YP_001177218.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein; KEGG: ypn:YPN_3527 major cold shock protein CspA2 YP_001177219.1 KEGG: sdy:SDY_1106 phosphatidylglycerophosphate synthetase CDP-1,2-diacyl-sn-glycero-3-phosphate phosphatidyl transferase; TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase YP_001177220.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001177221.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system YP_001177222.1 KEGG: stm:STM1949 cytoplasmic protein YP_001177223.1 regulates genes involved in cell division YP_001177224.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: ssn:SSO_1201 ATP-binding component of a transport system YP_001177225.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: stm:STM1952 ABC-type amino acid transporter, permease component YP_001177226.1 catalyzes the formation of pyruvate from D-cysteine YP_001177227.1 PFAM: extracellular solute-binding protein, family 3; SMART: ionotropic glutamate receptor; KEGG: sbo:SBO_1086 periplasmic binding transport protein YP_001177228.1 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence YP_001177229.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes YP_001177230.1 PFAM: acyl-CoA reductase; KEGG: sus:Acid_1365 hypothetical protein YP_001177231.1 PFAM: acyl-protein synthetase, LuxE; KEGG: sus:Acid_1364 acyl-protein synthetase, LuxE YP_001177232.1 PFAM: AMP-dependent synthetase and ligase; KEGG: sus:Acid_1363 AMP-dependent synthetase and ligase YP_001177233.1 PFAM: Transketolase, central region; Transketolase domain protein; KEGG: fnu:FN0295 transketolase YP_001177234.1 PFAM: Transketolase domain protein; KEGG: nca:Noca_4222 transketolase domain protein YP_001177235.1 PFAM: short-chain dehydrogenase/reductase SDR; KR; KEGG: shw:Sputw3181_1385 short-chain dehydrogenase/reductase SDR YP_001177236.1 PFAM: short-chain dehydrogenase/reductase SDR; KR; KEGG: aha:AHA_4175 oxidoreductase, short chain dehydrogenase/reductase family YP_001177237.1 KEGG: shw:Sputw3181_1384 acyl carrier protein YP_001177238.1 KEGG: aau:AAur_2153 acetyltransferase YP_001177239.1 PFAM: DegT/DnrJ/EryC1/StrS aminotransferase; KEGG: eca:ECA1733 nucleotide sugar transaminase YP_001177240.1 PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; Methyltransferase type 12; SMART: Tetratricopeptide domain protein; KEGG: eca:ECA1732 hypothetical protein YP_001177241.1 KEGG: rru:Rru_A2739 hypothetical protein YP_001177242.1 PFAM: flagellin domain protein; KEGG: eca:ECA1731 flagellin YP_001177243.1 PFAM: flagellar hook-associated protein 2 domain protein; flagellar hook-associated 2 domain protein; flagellin hook IN repeat protein; KEGG: ypn:YPN_2282 flagellar hook-associated protein 2 YP_001177244.1 flagellin specific chaperone YP_001177245.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family YP_001177246.1 converts 1,4-alpha-D-glucans to maltodextrin YP_001177247.1 KEGG: stm:STM1964 outer membrane lipoprotein YP_001177248.1 forms a junction between the M-ring and FlgB during flagella biosynthesis YP_001177249.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_001177250.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001177251.1 binds to and inhibits the function of flagella specific ATPase FliI YP_001177252.1 involved in type III protein export during flagellum assembly YP_001177253.1 rod/hook and filament chaperone YP_001177254.1 PFAM: flagellar hook-length control protein; KEGG: stm:STM1974 flagellar hook-length control protein YP_001177255.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring YP_001177256.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation YP_001177257.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001177258.1 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus YP_001177259.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_001177260.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus YP_001177261.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus YP_001177262.1 PFAM: regulatory protein, LuxR; KEGG: sbo:SBO_1056 positive regulator for ctr capsule biosynthesis, positive transcription factor YP_001177263.1 KEGG: sdy:SDY_1053 hypothetical protein YP_001177264.1 KEGG: stm:STM1984 cytoplasmic protein YP_001177265.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate YP_001177266.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: eci:UTI89_C2157 hypothetical protein YP_001177267.1 KEGG: sec:SC1992 cytoplasmic protein YP_001177268.1 PFAM: protein of unknown function DUF808; KEGG: spt:SPA0881 inner membrane protein YP_001177269.1 TIGRFAM: carboxylate/amino acid/amine transporter; PFAM: protein of unknown function DUF6, transmembrane; KEGG: ecv:APECO1_996 conserved predicted inner membrane protein YP_001177270.1 PFAM: DNA mismatch endonuclease vsr; KEGG: ecv:APECO1_997 DNA mismatch endonuclease, patch repair protein YP_001177271.1 KEGG: sdy:SDY_1045 DNA cytosine methylase; TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase YP_001177272.1 PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region; KEGG: ecj:JW1945 predicted phosphohydrolase YP_001177273.1 PFAM: porin, Gram-negative type; KEGG: ecv:APECO1_550 outer membrane pore protein N, non-specific YP_001177274.1 KEGG: ppr:PBPRB0267 GckR family protein YP_001177275.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration YP_001177276.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration YP_001177277.1 PFAM: ApbE family lipoprotein; KEGG: eca:ECA1970 thiamine biosynthesis protein YP_001177278.1 TIGRFAM: flavocytochrome c; PFAM: NADH:flavin oxidoreductase/NADH oxidase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; HI0933 family protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: eca:ECA1969 NADH:flavin oxidoreductase YP_001177279.1 TIGRFAM: anion transporter; PFAM: sodium/sulphate symporter; KEGG: ssn:SSO_3200 hypothetical protein YP_001177280.1 TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate alpha region; Fe-S type hydro-lyase tartrate/fumarate beta region; KEGG: sdy:SDY_4231 fumarase B YP_001177281.1 PFAM: protein of unknown function DUF980; KEGG: ssn:SSO_2035 hypothetical protein YP_001177282.1 KEGG: eca:ECA1581 hypothetical protein YP_001177283.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB YP_001177284.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation YP_001177285.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: cation transporting ATPase domain protein domain protein; Haloacid dehalogenase domain protein hydrolase; cation transporting ATPase domain protein; E1-E2 ATPase-associated domain protein; KEGG: yps:YPTB0594 Ca++ transporting P-type ATPase YP_001177286.1 PFAM: UspA domain protein; KEGG: sdy:SDY_0542 hypothetical protein YP_001177287.1 TIGRFAM: efflux transporter, RND family, MFP subunit; KEGG: yps:YPTB0565 lipoprotein, heavy metal/multidrug efflux, MFP family YP_001177288.1 PFAM: acriflavin resistance protein; KEGG: yps:YPTB0566 heavy metal/multi-drug efflux protein, RND family YP_001177289.1 KEGG: yps:YPTB1085 hypothetical protein YP_001177290.1 catalyzes the transfer of palmitate to lipid A YP_001177291.1 TIGRFAM: metabolite/H+ symporter, major facilitator superfamily (MFS); PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: ecs:ECs2778 shikimate transport protein YP_001177292.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_001177293.1 PFAM: creatinase; peptidase M24; KEGG: vch:VC0067 aminopeptidase P YP_001177294.1 TIGRFAM: MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE; KEGG: stm:STM2013 transport protein YP_001177295.1 PFAM: protein of unknown function DUF496; KEGG: sbo:SBO_0832 alpha helix protein YP_001177296.1 KEGG: stm:STM2060 inner membrane protein YP_001177297.1 PFAM: transcription activator, effector binding; KEGG: ecs:ECs2811 SbmC protein YP_001177298.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_001177299.1 KEGG: pau:PA14_59220 pyocin S5 YP_001177300.1 PFAM: acyltransferase 3; KEGG: ecc:c0970 hypothetical protein YP_001177301.1 KEGG: sfx:S0319 hypothetical bacteriophage protein YP_001177302.1 KEGG: ecv:APECO1_3907 hypothetical protein YP_001177303.1 PFAM: Baseplate J family protein; KEGG: sfv:SFV_0253 hypothetical protein YP_001177304.1 PFAM: phage GP46 family protein; KEGG: sfv:SFV_0252 tail protein YP_001177305.1 TIGRFAM: phage baseplate assembly protein V; PFAM: bacteriophage Mu Gp45 domain protein; KEGG: ecv:APECO1_3904 bacteriophage V tail protein YP_001177306.1 PFAM: bacteriophage Mu P family protein; KEGG: sfv:SFV_0250 tail protein YP_001177307.1 PFAM: DNA circulation family protein; KEGG: ecv:APECO1_3902 bacteriophage V tail/DNA circulation protein YP_001177308.1 TIGRFAM: phage tail tape measure protein, TP901 family; KEGG: sfv:SFV_0248 tail protein YP_001177309.1 KEGG: sfv:SFV_0247 bacteriophage protein YP_001177310.1 KEGG: ecv:APECO1_3899 hypothetical protein YP_001177311.1 PFAM: bacteriophage Mu tail sheath family protein; KEGG: sfv:SFV_0245 sheath protein YP_001177312.1 KEGG: eci:UTI89_C2974 hypothetical protein YP_001177313.1 KEGG: sfv:SFV_0244 bacteriophage protein YP_001177314.1 KEGG: ecv:APECO1_3896 hypothetical protein YP_001177315.1 TIGRFAM: phage head-tail adaptor, KEGG: sfv:SFV_0242 bacteriophage protein YP_001177316.1 TIGRFAM: uncharacterized phage protein (possible DNA packaging); KEGG: ecv:APECO1_3894 hypothetical protein YP_001177317.1 TIGRFAM: phage major capsid protein, HK97 family; PFAM: phage major capsid protein, HK97; KEGG: ecv:APECO1_1022 phage capsid protein YP_001177318.1 TIGRFAM: phage prohead protease, HK97 family; PFAM: peptidase U35, phage prohead HK97; KEGG: ecv:APECO1_1023 phage capsid protease YP_001177319.1 TIGRFAM: phage portal protein, HK97 family; PFAM: phage portal protein; KEGG: ecv:APECO1_1024 phage portal protein YP_001177321.1 PFAM: phage Terminase; KEGG: ecv:APECO1_3890 bacteriophage V large terminase subunit YP_001177322.1 TIGRFAM: phage terminase, small subunit, , P27 family; KEGG: hch:HCH_04557 phage terminase, small subunit, , P27 family YP_001177323.1 PFAM: HNH endonuclease; SMART: HNH nuclease; KEGG: ecv:APECO1_3888 phage endonuclease YP_001177324.1 KEGG: eca:ECA1664 lipoprotein YP_001177326.1 KEGG: sec:SC2612 hypothetical protein YP_001177327.1 PFAM: bacteriophage lysis protein; KEGG: ecj:JW5079 predicted murein endopeptidase YP_001177328.1 PFAM: glycoside hydrolase, family 24; KEGG: ecs:ECs2968 endolysin YP_001177329.1 PFAM: Lysis S family protein; KEGG: ecj:JW5255 predicted S lysis protein YP_001177330.1 PFAM: protein of unknown function UPF0150; KEGG: yen:YE1233 hypothetical protein YP_001177331.1 KEGG: ecc:c3206 hypothetical protein YP_001177332.1 PFAM: protein of unknown function DUF1133; KEGG: sec:SC1206 hypothetical protein YP_001177333.1 PFAM: protein of unknown function DUF1277; SMART: HNH nuclease; KEGG: ecv:APECO1_2036 hypothetical protein YP_001177334.1 KEGG: plu:plu2942 hypothetical protein YP_001177335.1 KEGG: yps:YPTB1793 hypothetical protein YP_001177337.1 KEGG: hit:NTHI1722 hypothetical protein YP_001177338.1 PFAM: peptidase S24, S26A and S26B; KEGG: ecv:APECO1_2045 regulatory protein YP_001177341.1 KEGG: vei:Veis_3662 hypothetical protein YP_001177342.1 KEGG: sec:SC0330 Eae protein YP_001177344.1 PFAM: phage integrase family protein; KEGG: sfv:SFV_2069 integrase of prophage YP_001177345.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates YP_001177346.1 PFAM: amino acid permease-associated region; KEGG: stm:STM2068 amino acid transport protein YP_001177347.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: ecv:APECO1_1112 predicted DNA-binding transcriptional regulator YP_001177348.1 PFAM: NAD-dependent epimerase/dehydratase; KEGG: stm:STM2070 dehydratase YP_001177349.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_001177350.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_001177351.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001177352.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate YP_001177353.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_001177354.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_001177355.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_001177356.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis YP_001177357.1 PFAM: lipopolysaccharide biosynthesis protein; KEGG: sbo:SBO_0853 regulator of length of O-antigen component of lipopolysaccharide chains YP_001177358.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain; KEGG: sgl:SG1369 nucleotide sugar epimerase YP_001177359.1 PFAM: UDP-glucose/GDP-mannose dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: sbo:SBO_0857 UDP-glucose 6-dehydrogenase YP_001177360.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_001177361.1 PFAM: phosphoglucomutase/phosphomannomutase C terminal; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; KEGG: ssn:SSO_2101 phosphomannomutase YP_001177362.1 KEGG: ecj:JW2034 mannose-1-phosphate guanyltransferase; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase, type II; Nucleotidyl transferase; Cupin 2, conserved barrel domain protein YP_001177363.1 PFAM: glycosyl transferase, group 1; KEGG: bth:BT_2864 glycosyltransferase involved in lipopolysaccharide biosynthesis YP_001177364.1 PFAM: glycosyl transferase, group 1; KEGG: plt:Plut_0774 glycosyl transferase, group 1 family protein YP_001177365.1 KEGG: syn:slr1074 hypothetical protein YP_001177366.1 PFAM: glycosyl transferase, family 2; KEGG: bxe:Bxe_A3720 glycosyl transferase YP_001177367.1 PFAM: polysaccharide biosynthesis protein; KEGG: cps:CPS_5012 polysaccharide biosynthesis protein YP_001177368.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; Male sterility C-terminal domain; KEGG: vfi:VF0169 hypothetical protein YP_001177369.1 KEGG: vfi:VF0168 dTDP-4-dehydrorhamnose 3,5-epimerase; TIGRFAM: dTDP-4-dehydrorhamnose 3,5-epimerase; PFAM: dTDP-4-dehydrorhamnose 3,5-epimerase related YP_001177370.1 TIGRFAM: glucose-1-phosphate thymidylyltransferase; PFAM: Nucleotidyl transferase; KEGG: ecj:JW2024 glucose-1-phosphate thymidylyltransferase YP_001177371.1 TIGRFAM: dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain; KEGG: sfx:S2227 dTDP-glucose 4,6 dehydratase YP_001177372.1 PFAM: transferase hexapeptide repeat containing protein; KEGG: bxe:Bxe_A3722 hypothetical protein YP_001177373.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose YP_001177374.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid YP_001177375.1 PFAM: glycosyl transferase, group 1; KEGG: eci:UTI89_C2316 colanic acid biosynthesis glycosyltransferase YP_001177376.1 PFAM: polysaccharide pyruvyl transferase; KEGG: ecs:ECs2850 galactokinase YP_001177377.1 PFAM: polysaccharide biosynthesis protein; KEGG: eci:UTI89_C2319 lipopolysaccharide biosynthesis protein WzxC YP_001177378.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid YP_001177379.1 PFAM: phosphoglucomutase/phosphomannomutase C terminal; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; KEGG: ecv:APECO1_1138 phosphomannomutase YP_001177380.1 KEGG: ssn:SSO_2102 mannose-1-phosphate guanyltransferase; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase, type II; Nucleotidyl transferase; Cupin 2, conserved barrel domain protein YP_001177381.1 PFAM: glycosyl transferase, group 1; KEGG: stm:STM2106 glycosyl transferase in colanic acid biosynthesis YP_001177382.1 PFAM: NUDIX hydrolase; KEGG: ecj:JW5335 GDP-mannose mannosyl hydrolase YP_001177383.1 PFAM: NAD-dependent epimerase/dehydratase; KEGG: ecc:c2578 GDP-fucose synthetase YP_001177384.1 TIGRFAM: GDP-mannose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; KEGG: sbo:SBO_0880 GDP-D-mannose dehydratase YP_001177385.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit) YP_001177386.1 PFAM: glycosyl transferase, family 2; KEGG: spt:SPA0755 glycosyltransferase YP_001177387.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance YP_001177388.1 KEGG: ecj:JW2042 predicted glycosyl transferase YP_001177389.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium YP_001177390.1 PFAM: glycosyl transferase, family 2; KEGG: stt:t0757 hypothetical protein YP_001177391.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide) YP_001177392.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis YP_001177393.1 PFAM: polysaccharide export protein; KEGG: ssn:SSO_2115 polysaccharide export protein YP_001177394.1 PFAM: CBS domain containing protein; transporter-associated region; Integral membrane protein TerC; KEGG: stm:STM2119 inner membrane protein YP_001177395.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs YP_001177396.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_001177397.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_001177398.1 contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction YP_001177399.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine YP_001177400.1 KEGG: sbo:SBO_0896 heat shock protein YP_001177401.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate YP_001177402.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate YP_001177403.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate YP_001177404.1 PFAM: major facilitator superfamily MFS_1; KEGG: ecj:JW2062 multidrug efflux system protein YP_001177405.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: ecp:ECP_2118 sensor protein BaeS YP_001177406.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport YP_001177407.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: reh:H16_A0106 lactoylglutathione lyase or related lyase YP_001177408.1 PFAM: Endoribonuclease L-PSP; KEGG: vpa:VP1797 hypothetical protein YP_001177409.1 PFAM: regulatory protein, TetR; KEGG: eca:ECA1819 TetR-family transcriptional regulator YP_001177410.1 PFAM: major facilitator superfamily MFS_1; KEGG: eca:ECA1818 transporter YP_001177411.1 PFAM: major facilitator superfamily MFS_1; KEGG: eca:ECA1817 probable transporter YP_001177412.1 PFAM: protein of unknown function DUF984; KEGG: eca:ECA0252 hypothetical protein YP_001177413.1 KEGG: eca:ECA2924 lipoprotein YP_001177414.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: gvi:glr3449 hypothetical protein YP_001177415.1 PFAM: peptidase U32; KEGG: ecv:APECO1_1176 hypothetical protein YP_001177416.1 PFAM: glutathione peroxidase; KEGG: ppr:PBPRB1182 glutathione peroxidase YP_001177417.1 KEGG: hso:HS_1260 hypothetical protein YP_001177418.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role YP_001177419.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: eca:ECA4072 ABC transporter ATP-binding protein YP_001177420.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: eca:ECA4073 ABC transporter ATP binding protein YP_001177421.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: eca:ECA4074 ABC transporter permease YP_001177422.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: eca:ECA4075 ABC transporter permease YP_001177423.1 PFAM: extracellular solute-binding protein, family 5; KEGG: eca:ECA4076 ABC transporter, substrate binding protein YP_001177424.1 PFAM: Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein; Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein; KEGG: eca:ECA4077 mandelate racemase / muconate lactonizing enzyme YP_001177425.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate YP_001177426.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_001177427.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_001177429.1 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde YP_001177430.1 PFAM: Pyridoxal-dependent decarboxylase; KEGG: eca:ECA2244 L-2,4-diaminobutyrate decarboxylase YP_001177431.1 PFAM: lipopolysaccharide biosynthesis protein; KEGG: sbo:SBO_2249 hypothetical protein YP_001177432.1 Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk YP_001177433.1 PFAM: polysaccharide export protein; KEGG: ssn:SSO_0990 function in exopolysaccharide production YP_001177434.1 KEGG: ssn:SSO_2155 hypothetical protein YP_001177435.1 PFAM: GCN5-related N-acetyltransferase; KEGG: yen:YE1087 acetyltransferase YP_001177436.1 KEGG: sfv:SFV_2169 ATPase YP_001177437.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_001177438.1 PFAM: protein of unknown function DUF1456; KEGG: sdy:SDY_2165 hypothetical protein YP_001177439.1 unknown function; when overproduced it confers drug-resistance YP_001177440.1 PFAM: GAF domain protein; ATP-binding region, ATPase domain protein domain protein; histidine kinase internal region; 5TM Receptors of the LytS-YhcK type, transmembrane region; KEGG: stm:STM2159 paral sensor/kinase in regulatory system YP_001177441.1 PFAM: regulatory protein, MerR; KEGG: ecv:APECO1_4422 MerR-like regulator A YP_001177442.1 KEGG: stm:STM2161 inner membrane protein YP_001177443.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ssn:SSO_2185 transport system permease YP_001177444.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: ssn:SSO_2186 ATP-binding component of a transport system YP_001177445.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: stm:STM2164 ABC-type proline/glycine betaine transport systems, permease component YP_001177446.1 PFAM: Substrate-binding region of ABC-type glycine betaine transport system; KEGG: ssn:SSO_2188 transport system permease YP_001177447.1 PFAM: glycoside hydrolase, family 3 domain protein; KEGG: ssn:SSO_2189 beta-D-glucoside glucohydrolase, periplasmic YP_001177448.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent YP_001177449.1 PFAM: GCN5-related N-acetyltransferase; KEGG: reu:Reut_A3272 GCN5-related N-acetyltransferase YP_001177450.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7 YP_001177451.1 PFAM: protein of unknown function DUF1282; KEGG: sbo:SBO_1009 hypothetical protein YP_001177452.1 KEGG: sdy:SDY_2152 hypothetical protein YP_001177453.1 PFAM: short-chain dehydrogenase/reductase SDR; KEGG: sbo:SBO_1007 oxidoreductase YP_001177454.1 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride YP_001177455.1 PFAM: glycoside hydrolase, family 1; KEGG: eca:ECA1871 6-phospho-beta-glucosidase YP_001177456.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001177457.1 PFAM: CAT RNA-binding domain protein; PRD domain protein; KEGG: eca:ECA1869 beta-glucoside operon antiterminator YP_001177458.1 PFAM: dihydrouridine synthase, DuS; KEGG: yps:YPTB1216 tRNA-dihydrouridine synthase C YP_001177460.1 PFAM: LrgA family protein; KEGG: stm:STM2181 hypothetical protein YP_001177461.1 PFAM: LrgB family protein; KEGG: sfv:SFV_2217 seritonin transporter YP_001177462.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_001177463.1 PFAM: protein of unknown function DUF218; KEGG: sdy:SDY_2143 vancomycin sensitivity YP_001177464.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex YP_001177465.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains YP_001177466.1 PFAM: periplasmic binding protein/LacI transcriptional regulator; KEGG: sdy:SDY_2130 galactose-binding transport protein YP_001177467.1 negative regulator of the mglBAC operon for galactose utilization YP_001177468.1 PFAM: protein of unknown function DUF405; protein of unknown function DUF418; KEGG: ecs:ECs3044 hypothetical protein YP_001177469.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_001177470.1 PFAM: protein of unknown function DUF1228; major facilitator superfamily MFS_1; KEGG: yps:YPTB1519 possible MFS superfamily transporter YP_001177471.1 PFAM: esterase; KEGG: ecv:APECO1_4397 esterase YP_001177472.1 Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein YP_001177473.1 PFAM: amino acid permease-associated region; KEGG: sdy:SDY_2110 lysine-specific permease YP_001177474.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: spt:SPA0650 transcriptional regulator YP_001177475.1 PFAM: conserved hypothetical protein 698; KEGG: sec:SC2218 inner membrane protein YP_001177476.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues YP_001177477.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001177478.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers YP_001177479.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr YP_001177480.1 TIGRFAM: sugar efflux transporter; PFAM: major facilitator superfamily MFS_1; KEGG: stm:STM2207 proton efflux pump YP_001177481.1 PFAM: protein of unknown function UPF0153; KEGG: ecp:ECP_2211 hypothetical protein YP_001177482.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein YP_001177483.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_001177484.1 PFAM: Mannitol dehydrogenase, C-terminal domain; Mannitol dehydrogenase rossman, N-terminal domain; KEGG: ecv:APECO1_4382 dehydrogenase, NAD-dependent YP_001177485.1 PFAM: cobalamin synthesis protein, P47K; cobalamin synthesis CobW domain protein; KEGG: stm:STM2212 cobalamin biosynthetic protein YP_001177486.1 PFAM: phosphoesterase, PA-phosphatase related; KEGG: stt:t0642 hypothetical protein YP_001177487.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance YP_001177488.1 PFAM: EAL domain protein; KEGG: stm:STM2215 hypothetical protein YP_001177489.1 PFAM: extracellular solute-binding protein, family 5; KEGG: ssn:SSO_2233 hypothetical protein YP_001177490.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ssn:SSO_2234 transport system permease YP_001177491.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ecj:JW2167 predicted oligopeptide transporter subunit YP_001177492.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: ecv:APECO1_4374 ABC transporter ATP-binding protein YejF YP_001177493.1 KEGG: stm:STM2220 cytoplasmic protein YP_001177494.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance YP_001177495.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA YP_001177496.1 PFAM: helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like; KEGG: ecs:ECs3076 ATP-dependent helicase YP_001177497.1 PFAM: ribosomal protein L25; KEGG: sdy:SDY_0894 50S ribosomal subunit protein L25 YP_001177498.1 PFAM: 37kDa nucleoid-associated protein; KEGG: stm:STM2226 nucleotide associated protein, present in spermidine nucleoids YP_001177499.1 PFAM: protein of unknown function DUF1414; KEGG: stm:STM2227 cytoplasmic protein YP_001177500.1 PFAM: sulfatase; KEGG: spt:SPA0622 sulphatase YP_001177501.1 PFAM: Fimbrial protein; KEGG: rme:Rmet_4253 fimbrial protein YP_001177502.1 KEGG: ssn:SSO_1801 hypothetical protein YP_001177503.1 PFAM: proteinase inhibitor I11, ecotin; KEGG: ecs:ECs3098 ecotin YP_001177504.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_001177505.1 PFAM: Benzoate membrane transport protein; Xanthine/uracil/vitamin C permease; sulphate transporter; KEGG: yen:YE0973 membrane transport protein YP_001177506.1 TIGRFAM: magnesium transporter; PFAM: CBS domain containing protein; MgtE integral membrane region; MgtE intracellular region; KEGG: aha:AHA_4122 magnesium transporter YP_001177507.1 efflux pump for the antibacterial peptide microcin J25 YP_001177508.1 PFAM: 2OG-Fe(II) oxygenase; KEGG: ssn:SSO_2270 DNA repair system specific for alkylated DNA YP_001177509.1 KEGG: ecc:c2754 ADA regulatory protein; TIGRFAM: methylated-DNA--protein-cysteine methyltransferase; PFAM: helix-turn-helix- domain containing protein, AraC type; methylated-DNA-[protein]-cysteine S-methyltransferase; Ada, metal-binding domain protein; methylguanine DNA methyltransferase, ribonuclease domain protein YP_001177510.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway YP_001177511.1 allows for ions and hydrophilic solutes to cross the outer membrane YP_001177512.1 PFAM: ATP-binding region, ATPase domain protein domain protein; Hpt domain protein; KEGG: stm:STM2269 sensor/kinase in regulatory system YP_001177513.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF YP_001177514.1 PFAM: response regulator receiver; ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; KEGG: ecc:c2761 sensor protein RcsC YP_001177515.1 negatively supercoils closed circular double-stranded DNA YP_001177516.1 Involved in ubiquinone biosynthesis YP_001177517.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001177518.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA YP_001177519.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases YP_001177520.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell YP_001177521.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor YP_001177522.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters YP_001177523.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate YP_001177524.1 TIGRFAM: molybdenum cofactor synthesis domain; competence/damage-inducible protein CinA; PFAM: molybdopterin binding domain; KEGG: stt:t0570 competence/damage-inducible protein CinA YP_001177525.1 PFAM: YfaZ family protein; KEGG: ecv:APECO1_4311 hypothetical protein YP_001177526.1 TIGRFAM: O-succinylbenzoate-CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: spt:SPA0558 O-succinylbenzoic acid-CoA ligase YP_001177527.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate YP_001177528.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_001177529.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA YP_001177530.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_001177531.1 KEGG: stm:STM2310 isochorismate synthase (isochorismate hydroxymutase 2), menaquinone biosynthesis; TIGRFAM: isochorismate synthase; PFAM: Anthranilate synthase component I and chorismate binding protein YP_001177532.1 PFAM: protein of unknown function DUF883, ElaB; KEGG: stm:STM2311 inner membrane protein YP_001177533.1 PFAM: GCN5-related N-acetyltransferase; KEGG: stm:STM2312 acyltransferase YP_001177534.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions YP_001177535.1 PFAM: response regulator receiver; CheW domain protein; KEGG: stm:STM2314 chemotaxis signal transduction protein YP_001177536.1 Catalyzes the transfer of electrons from NADH to quinone YP_001177537.1 Catalyzes the transfer of electrons from NADH to quinone YP_001177538.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_001177539.1 Catalyzes the transfer of electrons from NADH to quinone YP_001177540.1 Catalyzes the transfer of electrons from NADH to quinone YP_001177541.1 Catalyzes the transfer of electrons from NADH to quinone YP_001177542.1 Catalyzes the transfer of electrons from NADH to quinone YP_001177543.1 Catalyzes the transfer of electrons from NADH to quinone YP_001177544.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase YP_001177545.1 Catalyzes the transfer of electrons from NADH to quinone YP_001177546.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms YP_001177547.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_001177548.1 Catalyzes the transfer of electrons from NADH to quinone YP_001177549.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: sbo:SBO_2322 NADH dehydrogenase transcriptional regulator YP_001177550.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_001177551.1 PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region; KEGG: ecs:ECs3175 alpha helix protein YP_001177552.1 PFAM: Citrate transporter; TrkA-C domain protein; TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: sec:SC2334 response regulator YP_001177553.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: sec:SC2335 phosphatase YP_001177554.1 PFAM: YfbU family protein; KEGG: stm:STM2335 hypothetical protein YP_001177555.1 PFAM: protein of unknown function DUF412; KEGG: stm:STM2336 cytoplasmic protein YP_001177556.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_001177557.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_001177558.1 PFAM: Transketolase, central region; Transketolase domain protein; KEGG: stm:STM2340 transketolase YP_001177559.1 PFAM: Transketolase domain protein; KEGG: sec:SC2342 transketolase YP_001177560.2 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_001177561.1 PFAM: phosphotransferase system, lactose/cellobiose-specific IIB subunit; KEGG: stm:STM2343 sugar phosphotransferase component IIB YP_001177562.1 PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; KEGG: sec:SC2345 phosphotransferase system YP_001177563.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: stm:STM2345 transcriptional regulator YP_001177564.1 PFAM: NUDIX hydrolase; KEGG: stm:STM2346 NTP pyrophosphohydrolase YP_001177565.1 TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase; KEGG: sbo:SBO_2335 hypothetical protein YP_001177566.1 PFAM: Glutathione S-transferase, N-terminal domain; KEGG: stt:t0516 glutathione-S transferase YP_001177567.1 PFAM: Glutathione S-transferase, N-terminal domain; Glutathione S-transferase, C-terminal domain; KEGG: stm:STM2349 glutathione S-transferase YP_001177568.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate YP_001177569.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; domain of unknown function DUF1731; KEGG: stt:t0514 conserved hypothetical protein YP_001177570.1 PFAM: GCN5-related N-acetyltransferase; KEGG: pfl:PFL_2434 acetyltransferase, GNAT family YP_001177571.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: sdy:SDY_2505 ATP-binding component of histidine transport YP_001177572.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: sdy:SDY_2506 histidine transport, membrane protein M YP_001177573.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: stm:STM2353 ABC superfamily (membrane),histidine and lysine/arginine/ornithine transport system YP_001177574.1 TIGRFAM: cationic amino acid ABC transporter, periplasmic binding protein; PFAM: extracellular solute-binding protein, family 3; KEGG: sbo:SBO_2346 histidine-binding periplasmic protein of high-affinity histidine transport system YP_001177575.1 TIGRFAM: cationic amino acid ABC transporter, periplasmic binding protein; PFAM: extracellular solute-binding protein, family 3; KEGG: spt:SPA0509 lysine-arginine-ornithine-binding periplasmic protein precursor YP_001177576.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate YP_001177577.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_001177578.1 membrane protein required for colicin V production YP_001177579.1 PFAM: Sporulation domain protein; KEGG: stm:STM2364 DedD protein YP_001177580.1 TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein; KEGG: sfv:SFV_2384 dihydrofolate synthetase YP_001177581.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_001177582.1 KEGG: ecs:ECs3201 membrane protein YP_001177583.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001177584.1 PFAM: Semialdehyde dehydrogenase, NAD - binding; Semialdehyde dehydrogenase, dimerisation region; KEGG: ecv:APECO1_4245 USG-1 protein YP_001177585.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: ssn:SSO_2378 erythronate-4-phosphate dehyrogenase YP_001177586.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein YP_001177587.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001177588.2 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules YP_001177589.1 KEGG: sdy:SDY_2524 hypothetical protein YP_001177590.1 PFAM: protein of unknown function DUF462; KEGG: spt:SPA0483 cytoplasmic protein YP_001177591.1 PFAM: protein of unknown function DUF81; KEGG: stm:STM2382 permease YP_001177592.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm YP_001177593.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_001177594.1 involved in methylation of ribosomal protein L3 YP_001177595.1 PFAM: Smr protein/MutS2; KEGG: spt:SPA0478 hypothetical protein YP_001177596.1 TIGRFAM: phosphohistidine phosphatase SixA; PFAM: Phosphoglycerate mutase; KEGG: stt:t0477 phosphohistidine phosphatase YP_001177597.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate YP_001177598.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth YP_001177599.1 PFAM: conserved hypothetical protein 743; KEGG: stm:STM2390 cytoplasmic protein YP_001177600.1 PFAM: membrane protein involved in aromatic hydrocarbon degradation; KEGG: ecc:c2889 long-chain fatty acid transport protein precursor YP_001177601.1 PFAM: VacJ family lipoprotein; KEGG: stm:STM2392 lipoprotein precursor YP_001177602.1 KEGG: sdy:SDY_2551 transport YP_001177603.1 PFAM: phage integrase family protein; KEGG: ecp:ECP_4521 prophage P4 integrase YP_001177604.1 PFAM: Resolvase, N-terminal domain; Recombinase; KEGG: psp:PSPPH_0100 recombinase YP_001177605.1 PFAM: ParB domain protein nuclease; KEGG: pst:PSPTO_0033 ParB family protein YP_001177606.1 PFAM: RepB plasmid partition; SMART: ParB domain protein nuclease; KEGG: rsp:RSP_3814 hypothetical protein YP_001177607.1 KEGG: csa:Csal_2378 hypothetical protein YP_001177608.1 KEGG: vpa:VPA0444 hypothetical protein YP_001177609.1 PFAM: Radical SAM domain protein; KEGG: vpa:VPA0443 hypothetical protein YP_001177610.1 PFAM: Radical SAM domain protein; KEGG: vpa:VPA0442 hypothetical protein YP_001177612.1 KEGG: eca:ECA1066 hypothetical protein YP_001177613.1 PFAM: Relaxase/mobilization nuclease family protein; KEGG: yen:YE0984 repetative plasmid-related protein YP_001177614.1 KEGG: eca:ECA1063 hypothetical protein YP_001177615.1 KEGG: yen:YE0980 hypothetical protein YP_001177616.1 KEGG: yen:YE0979 conserved DNA-binding protein YP_001177617.1 PFAM: phage integrase family protein; KEGG: yen:YE0978 integrase/recombinase YP_001177618.1 PFAM: phage integrase family protein; KEGG: yen:YE0977 integrase/recombinase YP_001177619.1 KEGG: yen:YE0976 hypothetical protein YP_001177620.1 PFAM: Prophage CP4-57 regulatory; KEGG: yen:YE0975A hypothetical protein YP_001177621.1 KEGG: yen:YE0975 hypothetical protein YP_001177622.1 PFAM: ImpA domain protein; KEGG: yps:YPTB1506 hypothetical protein YP_001177623.1 KEGG: rso:RS05792 hypothetical protein YP_001177625.1 KEGG: rso:RS05792 hypothetical protein YP_001177626.1 PFAM: ImpA domain protein; KEGG: yps:YPTB1499 hypothetical protein YP_001177627.1 PFAM: ImcF domain protein; protein of unknown function DUF1215; KEGG: plu:plu4214 hypothetical protein YP_001177628.1 KEGG: yps:YPTB3248 PAL/OmpA-family membrane protein YP_001177629.1 PFAM: protein of unknown function DUF876; KEGG: ecv:APECO1_3716 hypothetical protein YP_001177630.1 PFAM: protein of unknown function DUF877; KEGG: eci:UTI89_C3191 hypothetical protein YP_001177631.1 PFAM: uncharacterised conserved protein UCP028301; KEGG: yps:YPTB3252 hypothetical protein YP_001177632.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock YP_001177633.1 PFAM: aminotransferase, class I and II; KEGG: ecv:APECO1_4158 aminotransferase YP_001177634.1 PFAM: GAF domain protein; ATP-binding region, ATPase domain protein domain protein; histidine kinase internal region; 5TM Receptors of the LytS-YhcK type, transmembrane region; KEGG: sbo:SBO_2406 sensor protein YP_001177635.1 PFAM: response regulator receiver; LytTr DNA-binding region; KEGG: eci:UTI89_C2713 hypothetical protein YpdB YP_001177636.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate YP_001177637.1 PFAM: Cl- channel, voltage-gated family protein; KEGG: spt:SPA0456 hypothetical protein YP_001177638.1 PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: stm:STM2405 indolepyruvate decarboxylase YP_001177639.1 PFAM: aldo/keto reductase; KEGG: spt:SPA0454 ion-channel protein YP_001177640.1 KEGG: sbo:SBO_2416 hypothetical protein YP_001177641.1 TIGRFAM: Mn2+/Fe2+ transporter, NRAMP family; PFAM: natural resistance-associated macrophage protein; KEGG: ece:Z3658 transport system permease YP_001177642.1 TIGRFAM: nucleoside transporter; PFAM: Na+ dependent nucleoside transporter; nucleoside recognition domain protein; Na+ dependent nucleoside transporter domain protein; KEGG: sdy:SDY_2593 permease of transport system for 3 nucleosides YP_001177643.1 PFAM: EAL domain protein; MASE1 domain protein; SMART: GGDEF domain containing protein; KEGG: sec:SC2413 diguanylate cyclase/phosphodiesterase domain 1; diguanylate cyclase/phosphodiesterase domain 2 YP_001177644.1 KEGG: stm:STM2413 negative regulator YP_001177645.1 KEGG: stt:t0443 hypothetical protein YP_001177646.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001177647.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: stm:STM2420 XapA transcriptional regulator YP_001177648.1 TIGRFAM: nucleoside transporter; PFAM: nucleoside:H+ symporter; major facilitator superfamily MFS_1; KEGG: stt:t0436 xanthosine permease YP_001177649.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation YP_001177650.1 KEGG: sfv:SFV_2459 hypothetical protein YP_001177651.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: sbo:SBO_2432 transcriptional regulator LysR-type YP_001177652.1 PFAM: Bile acid:sodium symporter; KEGG: spt:SPA0440 hypothetical protein YP_001177653.1 KEGG: sdy:SDY_2607 Z3676 gene product YP_001177654.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_001177655.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure YP_001177656.1 role in sulfur assimilation YP_001177657.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis YP_001177658.1 TIGRFAM: phosphocarrier, HPr family; PFAM: phosphocarrier HPr protein; KEGG: sdy:SDY_2612 PTS system protein HPr YP_001177659.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system YP_001177660.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose YP_001177661.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_001177662.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide YP_001177663.1 KEGG: sbo:SBO_2447 ATP-binding component of sulfate permease A protein; TIGRFAM: sulfate ABC transporter, ATPase subunit; PFAM: ABC transporter related; SMART: AAA ATPase YP_001177664.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import YP_001177665.1 TIGRFAM: sulfate ABC transporter, inner membrane subunit; sulfate ABC transporter, inner membrane subunit CysT; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: sbo:SBO_2449 sulfate, thiosulfate transport system permease T protein YP_001177666.1 TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein, family 1; KEGG: sfv:SFV_2478 thiosulfate binding protein YP_001177667.1 TIGRFAM: Dyp-type peroxidase family; PFAM: Dyp-type peroxidase; KEGG: stm:STM2446 iron-dependent peroxidase YP_001177668.1 PFAM: protein of unknown function DUF1131; KEGG: ecv:APECO1_4116 hypothetical protein YP_001177669.1 KEGG: sec:SC2447 inner membrane protein YP_001177670.1 PFAM: GCN5-related N-acetyltransferase; KEGG: sec:SC2448 acetyltransferase YP_001177671.1 PFAM: cell wall hydrolase/autolysin; KEGG: sbo:SBO_2460 N-acetylmuramoyl-L-alanine amidase I YP_001177672.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_001177673.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_001177674.1 KEGG: stm:STM2473 transaldolase A; TIGRFAM: transaldolase; PFAM: Transaldolase YP_001177675.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001177676.1 PFAM: protein of unknown function DUF1176; KEGG: ecp:ECP_2478 hypothetical protein YpfG precursor YP_001177677.1 PFAM: NUDIX hydrolase; KEGG: sfv:SFV_2511 hypothetical protein YP_001177678.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic) YP_001177679.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase, dimerisation and phosphoacceptor region; KEGG: stm:STM2480 sensory histidine kinase in two-component regulatory system with NarP ( NarL) YP_001177680.1 TIGRFAM: transporter, hydrophobe/amphiphile efflux-1 (HAE1) family; PFAM: acriflavin resistance protein; KEGG: ecv:APECO1_4087 aminoglycoside/multidrug efflux system YP_001177681.1 PFAM: arsenate reductase and related; KEGG: ecp:ECP_2484 hypothetical protein YffB YP_001177682.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_001177683.1 KEGG: sdy:SDY_2657 hypothetical protein YP_001177684.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate YP_001177685.1 PFAM: GCN5-related N-acetyltransferase; protein of unknown function DUF699, ATPase KEGG: ecv:APECO1_4083 hypothetical protein YP_001177686.1 PFAM: protein of unknown function, zinc metallopeptidase KEGG: sfv:SFV_2520 hypothetical protein YP_001177687.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001177688.1 PFAM: NlpBDapX family lipoprotein; KEGG: stm:STM2488 lipoprotein-34 YP_001177689.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001177690.1 negative transcriptional regulator of the gcvTHP operon YP_001177691.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine YP_001177692.1 PFAM: protein of unknown function UPF0118; KEGG: sdy:SDY_2682 permease YP_001177693.1 PFAM: peptidase M48, Ste24p; KEGG: ecc:c3011 hypothetical protein YfgC precursor YP_001177694.1 TIGRFAM: arsenate reductase; PFAM: arsenate reductase and related; KEGG: sdy:SDY_2684 oxidoreductase YP_001177695.1 KEGG: pca:Pcar_2728 transposase YP_001177696.1 TIGRFAM: PTS system, lactose/cellobiose family IIC subunit; PTS system, cellobiose-specific IIC subunit; PFAM: phosphotransferase system, EIIC; KEGG: bat:BAS5063 PTS system, cellobiose-specific IIC component YP_001177697.1 PFAM: peptidase T2, asparaginase 2; KEGG: lga:LGAS_1433 asparaginase YP_001177698.1 PFAM: peptidase M17, leucyl aminopeptidase domain protein; KEGG: pfo:Pfl_0989 peptidase M17, leucyl aminopeptidase-like YP_001177699.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP YP_001177700.1 TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: stt:t0360 uracil permease YP_001177701.1 TIGRFAM: uracil phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: stm:STM2498 uracil phosphoribosyltransferase YP_001177702.1 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism YP_001177703.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_001177704.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_001177705.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_001177706.1 PFAM: Ppx/GppA phosphatase; KEGG: stm:STM2502 exopolyphosphatase YP_001177707.1 PFAM: EAL domain protein; MASE1 domain protein; SMART: GGDEF domain containing protein; KEGG: stm:STM2503 diguanylate cyclase YP_001177708.1 KEGG: stm:STM2506 inner membrane protein YP_001177709.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: eca:ECA0955 LysR-family transcriptional regulator YP_001177710.1 PFAM: major facilitator superfamily MFS_1; KEGG: eca:ECA0957 hypothetical protein YP_001177711.1 PFAM: glycoside hydrolase, family 43; Glycosyl hydrolase family 32, N terminal domain protein; KEGG: lla:L0234 beta-1,4-xylosidase YP_001177712.1 TIGRFAM: sugar (Glycoside-Pentoside-Hexuronide) transporter; KEGG: lla:L0233 xyloside transporter YP_001177713.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001177714.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_001177715.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001177716.1 PFAM: protein of unknown function DUF1407; KEGG: sdy:SDY_2706 hypothetical protein YP_001177718.1 KEGG: plu:plu1550 hypothetical protein YP_001177719.1 PFAM: protein of unknown function DUF796; KEGG: plu:plu1552 hypothetical protein YP_001177720.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001177721.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis YP_001177722.1 KEGG: sdy:SDY_2709 hypothetical protein YP_001177723.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001177724.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_001177725.1 PFAM: helix-turn-helix domain protein; KEGG: ecs:ECs3378 hypothetical protein YP_001177726.1 TIGRFAM: radical SAM enzyme, Cfr family; PFAM: Radical SAM domain protein; KEGG: stm:STM2525 Fe-S-cluster redox enzyme YP_001177727.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_001177728.1 penicillin-insensitive transglycosylase/transpeptidase YP_001177729.1 PFAM: alpha-2-macroglobulin domain protein; alpha-2-macroglobulin domain protein 2; KEGG: ecs:ECs3386 hypothetical protein YP_001177730.1 KEGG: eca:ECA3225 PTS system, alpha-glucoside-specific IIbc component; TIGRFAM: PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS, EIIB protein; phosphotransferase system, EIIC YP_001177731.1 PFAM: glycoside hydrolase, family 4; KEGG: eca:ECA3226 6-phospho-alpha-glucosidase YP_001177732.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds YP_001177733.1 PFAM: helix-turn-helix protein RpiR; sugar isomerase (SIS); KEGG: plu:plu1987 hypothetical protein YP_001177734.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I YP_001177735.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide YP_001177736.1 PFAM: protein of unknown function DUF528; KEGG: sdy:SDY_2720 hypothetical protein YP_001177737.1 TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: stm:STM2538 [2FE-2S] ferredoxin, electron carrer protein, believed to be involved in assembly of Fe-S clusters YP_001177738.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_001177739.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins YP_001177740.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein YP_001177741.1 TIGRFAM: FeS cluster assembly scaffold IscU; PFAM: nitrogen-fixing NifU domain protein; KEGG: stm:STM2542 NifU homologs involved in Fe-S cluster formation YP_001177742.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_001177743.1 regulates the expression of the iscRSUA operon YP_001177744.1 TIGRFAM: RNA methyltransferase, TrmH family, group 1; PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: stm:STM2545 rRNA methylase YP_001177745.1 PFAM: inositol monophosphatase; KEGG: stm:STM2546 myo-inositol-1(or 4)-monophosphatase YP_001177746.1 PFAM: high-affinity nickel-transporter; KEGG: stm:STM2551 inner membrane protein YP_001177747.1 PFAM: protein of unknown function DUF1007; KEGG: stm:STM2552 hypothetical protein YP_001177748.1 PFAM: PRD domain protein; KEGG: stm:STM2553 stationary phase-inducible protein YP_001177749.1 transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters YP_001177750.1 PFAM: DoxX family protein; KEGG: ecs:ECs3409 hypothetical protein YP_001177751.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001177752.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine YP_001177753.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA YP_001177754.1 PFAM: response regulator receiver; sigma-54 factor, interaction domain-containing protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase; KEGG: sbo:SBO_2582 2-component transcriptional regulator YP_001177755.1 KEGG: stt:t0294 hypothetical protein YP_001177756.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: stm:STM2564 sensory kinase in regulatory system YP_001177757.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001177758.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function YP_001177759.1 PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: stm:STM2568 cytosine/adenosine deaminase YP_001177760.1 TIGRFAM: HAD superfamily (subfamily IF) hydrolase, YfhB; KEGG: ecs:ECs3426 hypothetical protein YP_001177761.1 PFAM: phosphotransferase system PTS, EIIB protein; phosphotransferase system, EIIC; KEGG: stm:STM2570 PTS system, sucrose-specific IIBC component YP_001177762.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_001177763.1 PFAM: helix-turn-helix protein RpiR; sugar isomerase (SIS); KEGG: sec:SC2567 ABC superfamily (membrane) transport protein YP_001177764.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: stm:STM2576 ferredoxin YP_001177765.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_001177766.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_001177767.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_001177768.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001177769.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_001177770.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins YP_001177771.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001177772.1 involved in the reduction of the SoxR iron-sulfur cluster YP_001177773.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP YP_001177774.1 PFAM: Anti sigma-E protein RseA family protein; Anti sigma-E protein RseA domain protein; KEGG: sfv:SFV_2635 sigma-E factor, negative regulatory protein YP_001177775.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_001177776.1 catalyzes the formation of oxaloacetate from L-aspartate YP_001177777.1 PFAM: RNA methylase; methyltransferase small; KEGG: ecv:APECO1_3956 hypothetical protein YP_001177778.1 facilitates an early step in the assembly of the 50S subunit of the ribosome YP_001177779.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit YP_001177780.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_001177781.1 PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase, substrate binding; KEGG: stm:STM2648 tRNA/rRNA methyltransferase YP_001177782.1 TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: sdy:SDY_2825 thioredoxin-like protein YP_001177783.1 PFAM: DTW domain containing protein; KEGG: sec:SC2655 cytoplasmic protein YP_001177784.1 PFAM: GCN5-related N-acetyltransferase; CoA-binding domain protein; KEGG: stm:STM2651 acetyl-CoA synthetase YP_001177785.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome YP_001177786.1 KEGG: ecp:ECP_2588 hypothetical protein YfiM YP_001177787.1 PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: sec:SC2663 ATP-dependent protease, Hsp 100, part of novel multi-chaperone system with DnaK, DnaJ, and GrpE YP_001177788.1 PFAM: protein of unknown function DUF152; KEGG: ssn:SSO_2719 hypothetical protein YP_001177789.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA YP_001177790.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline YP_001177791.1 associated with 30S ribosomal subunit; interferes with translation elongation YP_001177792.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_001177793.1 PFAM: SMP-30/Gluconolaconase/LRE domain protein; KEGG: sec:SC2670 cytoplasmic protein YP_001177794.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis YP_001177795.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_001177796.1 KEGG: ecs:ECs3465 hypothetical protein YP_001177797.1 KEGG: spt:SPA2530 hypothetical protein YP_001177798.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; histidine kinase, HAMP region domain protein; KEGG: spt:SPA2531 hypothetical protein YP_001177799.1 PFAM: OmpA/MotB domain protein; KEGG: ecv:APECO1_3928 outer membrane lipoprotein YP_001177800.1 PFAM: PepSY-associated TM helix domain protein; KEGG: eca:ECA1775 iron-regulated membrane protein YP_001177801.1 KEGG: xcb:XC_0986 hypothetical protein YP_001177802.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001177803.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001177804.1 Essential for efficient processing of 16S rRNA YP_001177805.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001177806.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins YP_001177807.1 PFAM: cytochrome c assembly protein; KEGG: sdy:SDY_2785 hypothetical protein YP_001177808.1 PFAM: CBS domain containing protein; protein of unknown function DUF21; transporter-associated region; KEGG: stm:STM2679 hypothetical protein YP_001177809.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_001177810.1 catalyzes the phosphorylation of NAD to NADP YP_001177811.1 TIGRFAM: DNA repair protein RecN; PFAM: SMC domain protein; KEGG: stt:t2638 DNA repair protein YP_001177812.1 PFAM: SmpA/OmlA domain protein; KEGG: stm:STM2685 small membrane protein A YP_001177813.1 PFAM: protein of unknown function UPF0125; KEGG: eci:UTI89_C2952 protein YfjF YP_001177814.1 PFAM: cyclase/dehydrase; KEGG: ecv:APECO1_3916 hypothetical protein YP_001177815.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001177816.1 PFAM: phage integrase family protein; KEGG: ypn:YPN_2899 prophage integrase YP_001177817.1 KEGG: she:Shewmr4_1846 ATP-dependent endonuclease of the OLD family-like protein YP_001177818.1 PFAM: phage polarity suppression; KEGG: stt:t4522 phage polarity suppression protein YP_001177819.1 PFAM: phage transcriptional activator, Ogr/delta; KEGG: stt:t4523 bacteriophage gene regulatory protein YP_001177820.1 KEGG: sbo:SBO_4170 hypothetical protein YP_001177821.1 PFAM: Prophage CP4-57 regulatory; KEGG: stt:t4525 phage DNA binding protein YP_001177822.1 KEGG: ecs:ECs0300 CI repressor YP_001177823.1 KEGG: spt:SPA4297 hypothetical protein YP_001177824.1 KEGG: spt:SPA4298 hypothetical P4 phage protein YP_001177825.1 KEGG: sty:STY4832 Bacteriophage P4 DNA primase; TIGRFAM: phage/plasmid primase, P4 family; PFAM: Poxvirus D5 protein; TOPRIM domain protein; Phage P4 alpha, zinc-binding domain protein; Helicase superfamily 3; SMART: Toprim sub domain protein YP_001177827.1 KEGG: ade:Adeh_3279 hypothetical protein YP_001177828.1 PFAM: protein of unknown function RIO1; KEGG: eca:ECA3207 RIO-type serine/threonine protein kinase YP_001177830.1 PFAM: YceI family protein; KEGG: eca:ECA2015 hypothetical protein YP_001177831.1 KEGG: eca:ECA2016 hypothetical protein YP_001177832.1 PFAM: sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: eca:ECA2017 RNA polymerase sigma factor YP_001177833.1 PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: pfo:Pfl_2884 hypothetical protein YP_001177834.1 TIGRFAM: outer membrane adhesin like proteiin; KEGG: spt:SPA2548 large repetitive protein YP_001177835.1 TIGRFAM: type I secretion outer membrane protein, TolC family; PFAM: outer membrane efflux protein; KEGG: stm:STM2690 outer membrane efflux protein YP_001177836.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase; KEGG: stm:STM2691 ABC transporter transmembrane region YP_001177837.1 TIGRFAM: type I secretion membrane fusion protein, HlyD family; PFAM: secretion protein HlyD family protein; KEGG: sec:SC2695 HlyD family secretion protein YP_001177838.1 PFAM: NUDIX hydrolase; KEGG: ecp:ECP_2294 NUDIX hydrolase YfaO YP_001177839.1 KEGG: plu:plu3350 hypothetical protein YP_001177840.1 PFAM: aminotransferase, class I and II; KEGG: eca:ECA4336 aminotransferase YP_001177841.1 KEGG: sfv:SFV_1273 hypothetical protein YP_001177842.1 PFAM: protein of unknown function DUF892; KEGG: ecj:JW1250 conserved hypothetical protein YP_001177843.1 PFAM: protein of unknown function DUF892; KEGG: stm:STM1730 cytoplasmic protein YP_001177844.1 PFAM: manganese containing catalase; KEGG: sec:SC1727 catalase YP_001177845.1 PFAM: cytochrome bd ubiquinol oxidase, subunit I; KEGG: stm:STM0360 cytochrome BD2 subunit I YP_001177846.1 TIGRFAM: cytochrome d ubiquinol oxidase, subunit II; PFAM: cytochrome bd ubiquinol oxidase, subunit II; KEGG: stm:STM0361 cytochrome BD2 subunit II YP_001177847.1 PFAM: CinA domain protein; KEGG: stm:STM1514 competence damage-inducible protein A YP_001177848.1 KEGG: dge:Dgeo_1459 hypothetical protein YP_001177850.1 PFAM: conserved hypothetical protein 156; KEGG: stm:STM1515 periplasmic protein YP_001177851.1 PFAM: virulence-related outer membrane protein; KEGG: ecs:ECs3850 virulence-related membrane protein YP_001177852.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: rso:RSc3332 probable transcription regulator protein YP_001177853.1 PFAM: short-chain dehydrogenase/reductase SDR; KR; KEGG: rso:RSc3331 short chain dehydrogenase YP_001177854.1 PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: bur:Bcep18194_B0726 methylase involved in ubiquinone/menaquinone biosynthesis-like YP_001177855.1 PFAM: Amidohydrolase 3; KEGG: ssn:SSO_0309 deaminase YP_001177856.1 PFAM: aspartate/glutamate/uridylate kinase; KEGG: ecp:ECP_0399 carbamate kinase-like protein YahI YP_001177857.1 PFAM: Xanthine/uracil/vitamin C permease; KEGG: mva:Mvan_3054 xanthine/uracil/vitamin C permease YP_001177858.1 PFAM: protein of unknown function DUF1116; KEGG: ecj:JW0313 conserved hypothetical protein YP_001177859.1 PFAM: FdrA family protein; KEGG: ecs:ECs0369 oxidoreductase subunit YP_001177860.1 PFAM: Ankyrin; KEGG: ecj:JW0310 predicted transcriptional regulator with ankyrin domain YP_001177861.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: ecv:APECO1_1674 DNA-bindng transcriptional regulator YP_001177862.1 PFAM: protein of unknown function UPF0057; KEGG: sdy:SDY_2856 hypothetical protein YP_001177863.1 KEGG: sec:SC2731 hypothetical protein YP_001177864.1 PFAM: histone family protein nucleoid-structuring protein H-NS; KEGG: sdy:SDY_2859 DNA-binding protein YP_001177865.1 PFAM: protein of unknown function DUF1144; KEGG: stm:STM2800 inner membrane protein YP_001177866.1 KEGG: sbo:SBO_2848 hypothetical protein YP_001177867.1 PFAM: protein of unknown function DUF883, ElaB; KEGG: sec:SC2735 inner membrane protein YP_001177868.1 TIGRFAM: glutaredoxin-like protein NrdH; PFAM: glutaredoxin; KEGG: sec:SC2739 glutaredoxin-like protein; hydrogen donor YP_001177869.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_001177870.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001177871.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_001177872.1 with ProWX is involved in the high-affinity uptake of glycine betaine YP_001177873.1 with ProVX is involved in the high-affinity uptake of glycine betaine YP_001177874.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine YP_001177875.1 PFAM: Integrase, catalytic region; KEGG: rpe:RPE_1052 integrase, catalytic region YP_001177876.1 PFAM: major facilitator superfamily MFS_1; KEGG: spt:SPA2670 transmembrane transport protein YP_001177877.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB YP_001177878.1 TIGRFAM: efflux pump membrane protein; PFAM: secretion protein HlyD family protein; KEGG: stt:t2711 multidrug resistance protein A YP_001177879.1 TIGRFAM: drug resistance transporter, EmrB/QacA subfamily; PFAM: major facilitator superfamily MFS_1; KEGG: ecc:c3239 multidrug resistance protein B YP_001177880.1 TIGRFAM: 2-isopropylmalate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: rpa:RPA4665 2-isopropylmalate synthase YP_001177881.1 PFAM: helix-turn-helix- domain containing protein, AraC type; AraC protein, arabinose-binding/dimerisation; Cupin 2, conserved barrel domain protein; KEGG: pau:PA14_48310 transcriptional regulator YP_001177882.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_001177883.1 involved in the first step of glutathione biosynthesis YP_001177884.1 KEGG: eci:UTI89_C3051 hypothetical protein YqaA YP_001177885.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent YP_001177886.1 affects carbohydrate metabolism; has regulatory role in many processes YP_001177887.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001177888.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_001177889.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001177890.1 PFAM: CinA domain protein; KEGG: ecc:c3254 competence/damage-inducible protein CinA C-terminal domain YP_001177891.1 PFAM: periplasmic solute binding protein; KEGG: sgl:SG0187 metal ion ABC transporter periplasmic component YP_001177892.1 PFAM: ABC-3 protein; KEGG: sgl:SG0186 metal ion ABC transporter permease component YP_001177893.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: sgl:SG0185 metal ion ABC transporter ATP-binding component YP_001177894.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan YP_001177895.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate YP_001177896.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon YP_001177897.1 detoxifies nitric oxide using NADH YP_001177898.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase YP_001177899.1 TIGRFAM: high-affinity nickel-transporter; KEGG: eca:ECA1252 high-affinity nickel transport protein YP_001177900.1 TIGRFAM: [NiFe] hydrogenase maturation protein HypF; PFAM: acylphosphatase; SUA5/yciO/yrdC, N-terminal domain; zinc finger, HypF domain protein; KEGG: stm:STM2842 hydrogenase maturation protein YP_001177901.1 involved in electron transport from formate to hydrogen YP_001177902.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: ssn:SSO_2858 ascBF operon repressor YP_001177903.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001177904.1 PFAM: glycoside hydrolase, family 1; KEGG: ecv:APECO1_3810 6-phospho-beta-glucosidase YP_001177905.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE YP_001177906.1 PFAM: formate hydrogenlyase maturation HycH; KEGG: sec:SC2779 processing of HycE (part of the FHL complex) YP_001177907.1 PFAM: NADH ubiquinone oxidoreductase, 20 kDa subunit; KEGG: stm:STM2847 hydrogenase YP_001177908.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate YP_001177909.1 PFAM: NADH-ubiquinone oxidoreductase, chain 49kDa; NADH dehydrogenase (ubiquinone), 30 kDa subunit; KEGG: stm:STM2849 hydrogenase 3 large subunit YP_001177910.1 PFAM: respiratory-chain NADH dehydrogenase, subunit 1; KEGG: sec:SC2783 hydrogenase 3, membrane subunit (part of FHL complex) YP_001177911.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3) YP_001177912.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: sec:SC2785 hydrogenase-3, iron-sulfur subunit (part of FHL complex) YP_001177913.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon YP_001177914.1 plays a role in hydrogenase nickel cofactor insertion YP_001177915.1 GTP hydrolase involved in nickel liganding into hydrogenases YP_001177916.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase YP_001177917.1 TIGRFAM: hydrogenase expression/formation protein HypD; PFAM: hydrogenase formation HypD protein; KEGG: ecv:APECO1_3796 protein required for maturation of hydrogenases YP_001177918.1 TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: sec:SC2791 hydrogenase expression/formation protein YP_001177919.1 PFAM: sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; GAF domain protein; SMART: AAA ATPase; KEGG: stm:STM2859 formate hydrogen-lyase transcriptional activator for fdhF, hyc and hyp operons (EBP family) YP_001177920.1 PFAM: periplasmic binding protein; KEGG: rle:pRL120713 substrate-binding component of ABC transporter YP_001177921.1 PFAM: transport system permease; ABC-3 protein; KEGG: ret:RHE_PF00270 probable iron ABC transporter, permease YP_001177922.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: ret:RHE_PF00271 probable iron ABC transporter, ATP-binding protein YP_001177923.1 PFAM: major facilitator superfamily MFS_1; KEGG: eca:ECA1550 transport system membrane protein YP_001177924.1 KEGG: ecp:ECP_2696 hypothetical protein YgbA YP_001177925.1 KEGG: plu:plu3591 hypothetical protein YP_001177926.1 This protein performs the mismatch recognition step during the DNA repair process YP_001177927.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses YP_001177928.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus YP_001177929.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins YP_001177930.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_001177931.1 catalyzes the modification of U13 in tRNA(Glu) YP_001177932.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_001177933.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_001177934.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein YP_001177935.1 KEGG: sfx:S2965 cytochrome oxidase subunit YP_001177936.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis YP_001177937.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ YP_001177938.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_001177939.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3 YP_001177940.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_001177941.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide YP_001177942.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity YP_001177943.1 TIGRFAM: 6-pyruvoyl tetrahydropterin synthase; PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: stm:STM2949 6-pyruvoyltetrahydropterin synthase YP_001177944.1 PFAM: Radical SAM domain protein; KEGG: sbo:SBO_2656 hypothetical protein YP_001177945.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_001177946.1 TIGRFAM: PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS, EIIB protein; phosphotransferase system, EIIC; KEGG: bcl:ABC0713 PTS system, glucose-specific enzyme II, ABC component YP_001177947.1 PFAM: helix-turn-helix protein RpiR; sugar isomerase (SIS); KEGG: vvy:VVA1198 transcriptional regulator YP_001177948.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001177949.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001177950.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era YP_001177951.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP YP_001177952.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_001177953.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system YP_001177954.1 PFAM: glycerate kinase; KEGG: stt:t2868 glycerate kinase YP_001177955.1 PFAM: Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein; KEGG: stm:STM2960 D-glucarate dehydratase YP_001177956.1 PFAM: Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein; Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein; KEGG: ssn:SSO_2945 glucarate dehydratase YP_001177957.1 TIGRFAM: d-galactonate transporter; PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: stm:STM2962 MFS superfamily, D-glucarate permease YP_001177958.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001177959.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp YP_001177960.1 PFAM: protein of unknown function DUF446; KEGG: sec:SC2905 cytoplasmic protein YP_001177961.1 SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function YP_001177962.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_001177963.1 PFAM: conserved hypothetical protein 730; KEGG: stm:STM2969 nucleotide binding YP_001177964.1 TIGRFAM: serine transporter; KEGG: stm:STM2970 HAAAP family, serine transport protein YP_001177965.1 KEGG: ssn:SSO_2954 L-serine dehydratase; TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain YP_001177966.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups YP_001177967.1 KEGG: ecc:c3376 hypothetical protein YgdE YP_001177968.1 PFAM: protein of unknown function DUF423; KEGG: ecv:APECO1_3724 inner membrane protein YP_001177969.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence YP_001177970.1 PFAM: protein of unknown function DUF903; KEGG: sdy:SDY_3027 hypothetical protein YP_001177971.1 PFAM: aminotransferase, class V; KEGG: ecp:ECP_2793 cysteine sulfinate desulfinase YP_001177972.1 PFAM: Fe-S metabolism associated SufE; KEGG: sbo:SBO_2694 hypothetical protein YP_001177973.1 PFAM: UBA/THIF-type NAD/FAD binding protein; KEGG: sfv:SFV_2891 enzyme YP_001177974.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_001177975.1 PFAM: cell wall hydrolase/autolysin; KEGG: sbo:SBO_2707 amidase YP_001177976.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_001177977.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_001177978.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_001177979.1 PFAM: peptidase M16 domain protein; KEGG: sfv:SFV_2899 protease III YP_001177980.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination YP_001177981.1 KEGG: stt:t2905 prepilin peptidase dependent protein C precursor YP_001177982.1 KEGG: ecj:JW5451 conserved hypothetical protein YP_001177983.1 KEGG: sec:SC2938 prepilin peptidase dependent protein A, component in type IV pilin biogenesis YP_001177984.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_001177985.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_001177986.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr YP_001177987.1 hydrolyzes diadenosine polyphosphate YP_001177988.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair YP_001177989.1 PFAM: protein of unknown function DUF903; KEGG: sdy:SDY_3050 hypothetical protein YP_001177990.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH YP_001177991.1 PFAM: major facilitator superfamily MFS_1; KEGG: ecp:ECP_2848 hypothetical protein YP_001177992.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1 YP_001177993.1 controls transcription of galETKM YP_001177994.1 PFAM: GCN5-related N-acetyltransferase; KEGG: eca:ECA3643 GnaT-family acetyltransferase YP_001177995.1 PFAM: regulatory protein GntR, HTH; GntR domain protein; KEGG: eca:ECA3644 GntR-family transcriptional regulator YP_001177996.1 PFAM: glycoside hydrolase, family 1; KEGG: eca:ECA3646 6-phospho-beta-glucosidase YP_001177997.1 TIGRFAM: PTS system, lactose/cellobiose family IIC subunit; PFAM: phosphotransferase system, EIIC; KEGG: eca:ECA3647 PTS system, lichenan-specific IIc component YP_001177998.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: stm:STM3012 transcriptional regulator YP_001177999.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding YP_001178000.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase YP_001178001.1 TIGRFAM: aspartate racemase; PFAM: Asp/Glu racemase; KEGG: stt:t2925 hypothetical protein YP_001178002.1 PFAM: Cupin 2, conserved barrel domain protein; KEGG: vpa:VPA0079 pectin degradation protein (sugar phosphate isomerase family) YP_001178003.1 PFAM: Integrase, catalytic region; KEGG: rpe:RPE_1052 integrase, catalytic region YP_001178004.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: yps:YPTB2359 ABC sugar transporter (permease) YP_001178005.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: eca:ECA2404 binding-protein-dependent transport system, inner membrane component YP_001178006.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: eca:ECA2405 ABC transporter, ATP-binding component YP_001178007.1 PFAM: extracellular solute-binding protein, family 1; KEGG: eca:ECA2406 periplasmic pectic oligomers binding protein YP_001178008.1 KEGG: eca:ECA2426 oligogalacturonate lyase YP_001178009.1 TIGRFAM: sugar transporter; PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: spt:SPA2883 L-arabinose isomerase YP_001178010.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate YP_001178011.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate YP_001178012.1 KEGG: yps:YPTB2368 oligogalacturonate lyase YP_001178013.1 PFAM: Oligogalacturonate-specific porin; KEGG: stm:STM1131 outer membrane protein YP_001178014.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_001178015.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: spt:SPA2887 possible regulatory protein YP_001178016.1 PFAM: transmembrane pair domain protein; KEGG: stm:STM3021 inner membrane protein YP_001178017.1 PFAM: Spore germination protein; KEGG: ecv:APECO1_3661 transport protein YP_001178018.1 PFAM: GCN5-related N-acetyltransferase; KEGG: ilo:IL2068 acetyltransferase, GNAT family YP_001178019.1 KEGG: sdy:SDY_4240 hypothetical protein YP_001178020.1 PFAM: protein of unknown function DUF1271; KEGG: ecs:ECs5108 hypothetical protein YP_001178021.1 PFAM: Peptidoglycan-binding LysM; peptidase M23B; KEGG: stm:STM3038 metalloendopeptidase YP_001178022.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate YP_001178023.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_001178024.1 5'-3' single-stranded-DNA-specific exonuclease YP_001178025.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity YP_001178026.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001178027.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic YP_001178028.1 PFAM: protein of unknown function DUF1434; KEGG: stm:STM3046 inner membrane protein YP_001178029.1 PFAM: protein of unknown function DUF339; KEGG: sdy:SDY_3185 hypothetical protein YP_001178030.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator YP_001178031.1 TIGRFAM: channel protein, hemolysin III family; PFAM: Hly-III family protein; KEGG: sfv:SFV_2947 oxidoreductase YP_001178032.1 PFAM: uncharacterised conserved protein UCP029143; KEGG: stm:STM3050 hypothetical protein YP_001178033.1 PFAM: helix-turn-helix protein RpiR; sugar isomerase (SIS); KEGG: yen:YE1415 LacI-family regulatory protein YP_001178034.1 PFAM: glycoside hydrolase, family 1; KEGG: ecp:ECP_2895 6-phospho-beta-glucosidase BglA YP_001178035.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR; KEGG: sfx:S3087 oxidoreductase YP_001178036.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_001178037.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_001178038.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_001178039.1 TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: monooxygenase, FAD-binding; FAD dependent oxidoreductase; KEGG: stm:STM3056 hypothetical protein YP_001178040.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone YP_001178041.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide YP_001178042.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown YP_001178043.1 PFAM: protein of unknown function DUF710; KEGG: stm:STM3060 cytoplasmic protein YP_001178044.1 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function YP_001178045.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_001178046.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_001178047.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_001178048.1 PFAM: protein of unknown function DUF541; KEGG: stm:STM3065 hypothetical protein YP_001178049.1 Involved in the export of arginine YP_001178050.1 participates in the regulation of osmotic pressure changes within the cel YP_001178051.2 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_001178052.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_001178053.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate YP_001178054.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001178055.1 PFAM: peptidase M48, Ste24p; KEGG: sbo:SBO_3053 hypothetical protein YP_001178056.1 catalyzes the formation of putrescine from agmatine YP_001178057.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis YP_001178058.1 KEGG: spt:SPA2952 hypothetical protein YP_001178059.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001178060.1 TIGRFAM: sugar transporter; PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: stm:STM3091 MFS family, galactose:proton symporter YP_001178061.1 PFAM: protein of unknown function DUF335, SprT; SMART: protein of unknown function SprT; KEGG: ssn:SSO_3098 hypothetical protein YP_001178062.1 PFAM: Endonuclease I; KEGG: spt:SPA2956 endonuclease I YP_001178063.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001178064.1 The second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_001178065.1 PFAM: protein of unknown function DUF179; KEGG: sdy:SDY_3124 hypothetical protein YP_001178066.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_001178067.1 SMART: regulatory protein, IclR; KEGG: stm:STM3098 transcriptional regulator YP_001178068.1 KEGG: ppe:PEPE_0550 pyridine nucleotide-disulphide oxidoreductase YP_001178069.1 TIGRFAM: twitching motility protein; PFAM: type II secretion system protein E; KEGG: ecj:JW2917 predicted transporter YP_001178070.1 PFAM: alanine racemase domain protein; KEGG: sdy:SDY_3122 hypothetical protein YP_001178071.1 PFAM: protein of unknown function YGGT; KEGG: stm:STM3101 integral membrane protein YP_001178072.1 PFAM: protein of unknown function DUF167; KEGG: stt:t3014 hypothetical protein YP_001178073.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_001178074.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001178075.1 PFAM: protein of unknown function DUF559; KEGG: mca:MCA0029 hypothetical protein YP_001178076.1 KEGG: stm:STM3107 periplasmic protein YP_001178077.1 PFAM: protein of unknown function DUF469; KEGG: ecv:APECO1_3562 hypothetical protein YP_001178078.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_001178079.1 KEGG: ecj:JW2928 adenine DNA glycosylase; TIGRFAM: A/G-specific adenine glycosylase; PFAM: helix-hairpin-helix motif; HhH-GPD family protein; SMART: iron-sulfur cluster loop YP_001178080.1 PFAM: Fe(II) trafficking protein YggX; KEGG: sdy:SDY_3110 hypothetical protein YP_001178081.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_001178082.1 TIGRFAM: nucleoside transporter; PFAM: nucleoside:H+ symporter; major facilitator superfamily MFS_1; KEGG: stm:STM3113 MFS family, nucleoside transport YP_001178083.1 PFAM: triphosphoribosyl-dephospho-CoA protein; KEGG: eca:ECA2569 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase YP_001178084.1 PFAM: Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; KEGG: eca:ECA2570 apo-citrate lyase phosphoribosyl-dephospho-CoA transferase YP_001178085.1 KEGG: eca:ECA2571 citrate lyase alpha chain; TIGRFAM: citrate lyase, alpha subunit; PFAM: Citrate lyase, alpha subunit YP_001178086.1 KEGG: eca:ECA2572 citrate lyase beta chain; TIGRFAM: citrate lyase, beta subunit; PFAM: HpcH/HpaI aldolase YP_001178087.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate YP_001178088.1 KEGG: eca:ECA2574 [citrate [pro-3s]-lyase] ligase; TIGRFAM: cytidyltransferase-related domain; citrate lyase ligase; PFAM: GCN5-related N-acetyltransferase; cytidylyltransferase; Citrate lyase ligase, C-terminal domain protein YP_001178089.1 PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: eca:ECA2575 fumarylacetoacetate hydrolase YP_001178090.1 PFAM: Citrate carrier protein; KEGG: eca:ECA2576 citrate/acetate antiporter YP_001178091.1 PFAM: ATP-binding region, ATPase domain protein domain protein; PAS fold domain protein; SMART: PAS domain containing protein; KEGG: eca:ECA2577 two-component sensor kinase YP_001178092.1 PFAM: response regulator receiver; KEGG: eca:ECA2578 two-component response regulator YP_001178093.1 PFAM: Orn/Lys/Arg decarboxylase, major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: ecs:ECs3841 ornithine decarboxylase isozyme YP_001178094.1 PFAM: protein of unknown function DUF554; KEGG: stm:STM3115 inner membrane protein YP_001178095.1 KEGG: pen:PSEEN0173 hypothetical protein YP_001178096.1 TIGRFAM: outer membrane autotransporter barrel domain; PFAM: Autotransporter beta- domain protein; KEGG: rso:RSc3162 hemagglutinin-related protein YP_001178097.1 KEGG: ecv:APECO1_2331 inner membrane protein YP_001178098.1 KEGG: mxa:MXAN_2171 hypothetical protein YP_001178099.1 KEGG: pol:Bpro_4794 hypothetical protein YP_001178100.1 PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: nha:Nham_4645 sigma-24 (FecI-like) YP_001178101.1 PFAM: cytochrome c biogenesis protein, transmembrane region; KEGG: ccr:CC0217 ThiO:disulfide interchange protein YP_001178102.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein; KEGG: sal:Sala_1162 alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen YP_001178103.1 PFAM: YfaZ family protein; KEGG: yps:YPTB1247 hypothetical protein YP_001178104.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction YP_001178105.1 YghU; B2989; one of eight glutathione transferases from E. coli YP_001178106.1 TIGRFAM: molybdenum ABC transporter, periplasmic molybdate-binding protein; KEGG: spt:SPA3009 molybdate transport system substrate-binding protein YP_001178107.1 PFAM: periplasmic binding protein; KEGG: sec:SC3083 ferrichrome-binding periplasmic protein YP_001178108.1 PFAM: MscS Mechanosensitive ion channel; Conserved TM helix repeat-containing protein; KEGG: stm:STM4102 inner membrane protein YP_001178109.1 PFAM: protein of unknown function UPF0118; KEGG: sgl:SG1430 hypothetical protein YP_001178110.1 KEGG: sfv:SFV_1176 hypothetical protein YP_001178111.1 PFAM: regulatory protein, LuxR; KEGG: chu:CHU_0659 fimbrial Z protein; probable signal transducer YP_001178112.1 PFAM: regulatory protein, LuxR YP_001178113.1 KEGG: rme:Rmet_2595 hypothetical protein YP_001178114.1 KEGG: ecp:ECP_0434 hypothetical protein YaiV YP_001178115.1 KEGG: aha:AHA_0727 diguanylate cyclase/phosphodiesterase domain 2; TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; PAS fold-3 domain protein; SMART: PAS domain containing protein YP_001178116.1 regulates expression of genes involved in L-fucose utilization YP_001178117.1 KEGG: sdy:SDY_3075 hypothetical protein YP_001178118.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; KEGG: stm:STM3152 methyl-accepting chemotaxis protein YP_001178119.1 TIGRFAM: outer membrane autotransporter barrel domain; PFAM: Autotransporter beta- domain protein; KEGG: bps:BPSL1631 outer membrane protein YP_001178120.1 PFAM: dienelactone hydrolase; KEGG: ecp:ECP_3085 predicted hydrolase YP_001178121.1 PFAM: aldo/keto reductase; KEGG: ecp:ECP_3086 hypothetical protein YghZ (aldo/keto reductase) YP_001178122.1 PFAM: Uncharacterized protein UPF0114; KEGG: sbo:SBO_2996 hypothetical protein YP_001178123.1 KEGG: stm:STM3154 ATP-dependent RNA helicase-like protein YP_001178124.1 KEGG: spt:SPA3023 hypothetical protein YP_001178125.1 KEGG: stm:STM3156 cytoplasmic protein YP_001178126.1 PFAM: short-chain dehydrogenase/reductase SDR; KR; KEGG: stm:STM3157 oxidoreductase YP_001178127.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_001178128.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_001178129.1 catalyzes the formation of L-homocysteine from cystathionine YP_001178130.1 KEGG: ssn:SSO_3152 hypothetical protein YP_001178131.1 PFAM: helix-turn-helix- domain containing protein, AraC type; AraC-type transcriptional regulator domain protein; KEGG: sdy:SDY_3062 AraC-type regulatory protein YP_001178132.1 PFAM: iron-containing alcohol dehydrogenase; KEGG: sec:SC3108 alcohol dehydrogenase YP_001178133.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate YP_001178134.1 PFAM: Radical SAM domain protein; Radical SAM N-terminal domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: ecv:APECO1_3410 Fe-S oxidoreductase YP_001178135.1 PFAM: multicopper oxidase, type 2; multicopper oxidase, type 3; KEGG: stm:STM3172 suppressor of ftsI, periplasmic protein YP_001178136.1 KEGG: stm:STM3173 1-acyl-sn-glycerol-3-phosphate acyltransferase; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: phospholipid/glycerol acyltransferase YP_001178137.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001178138.1 PFAM: conserved hypothetical protein 156; KEGG: stm:STM3176 outer membrane protein YP_001178139.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes YP_001178140.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: stm:STM3178 sensory histidine kinase in regulatory system YP_001178141.1 PFAM: NAD(P)H dehydrogenase (quinone); KEGG: stm:STM3179 NADPH specific quinone oxidoreductase (drug modulator) YP_001178142.1 PFAM: Antibiotic biosynthesis monooxygenase; KEGG: stm:STM3180 cytoplasmic protein YP_001178143.1 PFAM: glycosyl hydrolase, family 88; KEGG: sgl:SG2119 glucuronyl hydrolase YP_001178144.1 TIGRFAM: oligosaccharide/H+ symporter, major facilitator superfamily (MFS); PFAM: proton/sugar symporter, LacY; major facilitator superfamily MFS_1; KEGG: bld:BLi04179 similar to sugar permease; RBL02034 YP_001178145.1 KEGG: sme:SMb20536 hypothetical protein YP_001178146.1 PFAM: helix-turn-helix- domain containing protein, AraC type; KEGG: sgl:SG2118 hypothetical protein YP_001178147.1 PFAM: helix-turn-helix protein RpiR; sugar isomerase (SIS); KEGG: ecs:ECs3912 transcriptional regulator YP_001178148.1 PFAM: periplasmic binding protein; KEGG: ecv:APECO1_3388 iron compound-binding protein of ABC transporter family YP_001178149.1 PFAM: transport system permease; KEGG: ecs:ECs3914 permease of ferrichrome ABC transporter YP_001178150.1 PFAM: transport system permease; KEGG: ecv:APECO1_3386 iron compound permease of ABC transporter family YP_001178151.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: ecc:c3774 ferric enterobactin transport ATP-binding protein fepC YP_001178152.1 TIGRFAM: TonB-dependent siderophore receptor; PFAM: TonB-dependent receptor; TonB-dependent receptor, plug; KEGG: ecs:ECs3917 ferrichrome iron receptor precursor YP_001178153.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001178154.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate YP_001178155.1 PFAM: metallophosphoesterase; Calcineurin phosphoesterase C-terminal domain protein; KEGG: eci:UTI89_C3466 icc protein YP_001178156.1 PFAM: protein of unknown function DUF1249; KEGG: ssn:SSO_3171 enzyme YP_001178157.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_001178158.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell YP_001178159.1 KEGG: ssn:SSO_3174 hypothetical protein YP_001178160.1 PFAM: glutathionylspermidine synthase; KEGG: stm:STM3188 glutathionylspermidine synthase YP_001178161.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine YP_001178162.1 PFAM: zinc/iron permease; KEGG: ssn:SSO_3177 hypothetical protein YP_001178163.1 DHBP synthase; functions during riboflavin biosynthesis YP_001178164.1 PFAM: protein of unknown function DUF526; KEGG: sec:SC3142 cytoplasmic protein YP_001178165.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose YP_001178166.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_001178167.1 PFAM: CHAD domain containing protein; adenylate cyclase; KEGG: sbo:SBO_2910 hypothetical protein YP_001178168.1 SMART: SH3 domain protein domain protein; KEGG: stm:STM3203 SH3 domain protein YP_001178169.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases YP_001178170.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_001178171.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin YP_001178172.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_001178173.1 PFAM: Urease accessory protein UreD; KEGG: ecs:ECs1321 urease-associated protein UreD YP_001178174.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter YP_001178175.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active YP_001178176.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits YP_001178177.1 involved in the assembly of the urease metallocenter; possible nickel donor YP_001178178.1 PFAM: Urease accessory protein UreF; KEGG: ecs:ECs1326 urease accessory protein UreF YP_001178179.1 TIGRFAM: urease accessory protein UreG; PFAM: cobalamin synthesis protein, P47K; KEGG: pen:PSEEN2100 urease accessory protein UreG YP_001178180.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001178181.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_001178182.1 synthesizes RNA primers at the replication forks YP_001178183.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_001178184.1 PFAM: Uracil-DNA glycosylase superfamily; KEGG: sbo:SBO_2927 G/U mismatch-specific DNA glycosylase YP_001178185.1 in E. coli K-12 this is in prophage P2 remnant YP_001178186.1 PFAM: phage late control D family protein; KEGG: ecv:APECO1_1177 phage protein D YP_001178187.1 PFAM: phage P2 GpU family protein; KEGG: ecv:APECO1_1178 phage protein U YP_001178188.1 TIGRFAM: phage tail tape measure protein, TP901 family; KEGG: ecv:APECO1_11 gpT YP_001178189.1 PFAM: phage P2 GpE family protein; KEGG: stt:t3441 hypothetical protein YP_001178190.1 PFAM: phage tail E family protein; KEGG: yps:YPTB1743 tail protein gpE P2 bacteriophage YP_001178191.1 PFAM: phage major tail tube protein; KEGG: ecv:APECO1_9 gpFII YP_001178192.1 PFAM: phage tail sheath protein; KEGG: yps:YPTB1745 tail sheath protein (P2 and 186 bacteriophage) YP_001178193.1 PFAM: phage tail assembly chaperone gp38; KEGG: ecj:JW1142 predicted tail fiber assembly protein YP_001178194.1 PFAM: phage Tail Collar domain protein; KEGG: plu:plu0021 hypothetical protein YP_001178195.1 TIGRFAM: phage tail protein I; KEGG: yps:YPTB1748 bacteriophage protein YP_001178196.1 PFAM: Baseplate J family protein; KEGG: ecv:APECO1_4480 baseplate assembly protein YP_001178197.1 PFAM: GPW/gp25 family protein; KEGG: yps:YPTB1750 possible phage-related protein YP_001178198.1 PFAM: phage baseplate assembly protein V; KEGG: ecv:APECO1_4478 phage baseplate protein YP_001178199.1 TIGRFAM: phage virion morphogenesis protein; PFAM: phage virion morphogenesis ( tail completion) protein; KEGG: yps:YPTB1752 O protein [Enterobacteria phage 186] YP_001178200.1 PFAM: P2 phage tail completion R family protein; KEGG: ecv:APECO1_4476 tail protein YP_001178201.1 KEGG: stm:STM2713 hypothetical protein YP_001178202.1 KEGG: ecv:APECO1_4474 LysA protein YP_001178203.1 PFAM: glycoside hydrolase, family 24; KEGG: yps:YPTB1755 phage lysozyme YP_001178204.1 KEGG: yps:YPTB1756 prophage Hp1 family holin YP_001178205.1 PFAM: phage tail X family protein; KEGG: yps:YPTB1757 phage-related tail protein YP_001178206.1 PFAM: phage head completion; KEGG: ecv:APECO1_4471 capsid completion protein YP_001178207.1 PFAM: phage small terminase subunit; Tetratricopeptide TPR_2 repeat protein; KEGG: ecv:APECO1_4470 small terminase subunit YP_001178208.1 TIGRFAM: phage major capsid protein, P2 family; PFAM: phage major capsid protein, P2; KEGG: ecv:APECO1_4469 major capsid protein YP_001178209.1 PFAM: phage capsid scaffolding; KEGG: ecv:APECO1_4468 phage capsid scaffolding protein YP_001178210.1 PFAM: protein of unknown function DUF264; terminase ATPase subunit; KEGG: ecv:APECO1_1180 phage protein P YP_001178211.1 TIGRFAM: phage portal protein, PBSX family; PFAM: phage portal protein; KEGG: ecv:APECO1_1181 phage protein Q YP_001178212.1 KEGG: pae:PA1370 hypothetical protein YP_001178213.1 PFAM: DinI family protein; KEGG: spt:SPA2588 hypothetical protein YP_001178214.1 PFAM: bacteriophage replication gene A; KEGG: yen:YE1686 phage replication protein YP_001178215.1 PFAM: phosphoadenosine phosphosulfate reductase; KEGG: bte:BTH_II1030 GP57 YP_001178216.1 TIGRFAM: phage/conjugal plasmid C-4 type zinc finger protein, TraR family; PFAM: zinc finger, DksA/TraR C4-type; KEGG: spt:SPA2593 hypothetical protein YP_001178217.1 KEGG: stm:STM2732 hypothetical protein YP_001178218.1 KEGG: stm:STM2733 hypothetical protein YP_001178219.1 KEGG: ecc:c0937 hypothetical protein YP_001178220.1 PFAM: phage regulatory CII family protein; KEGG: stm:STM2736 hypothetical protein YP_001178222.1 PFAM: bacteriophage CI repressor; KEGG: sbo:SBO_0748 repressor protein YP_001178223.1 PFAM: phage integrase family protein; KEGG: stt:t3400 probable bacteriophage integrase YP_001178224.1 KEGG: pin:Ping_2001 hypothetical protein YP_001178225.1 catalyzes the transfer of phosphoglycerol to the glucan backbone YP_001178226.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: eca:ECA3556 LysR-family transcriptional regulator YP_001178227.1 PFAM: beta-lactamase domain protein; KEGG: eca:ECA3557 metallo hydrolase YP_001178228.1 PFAM: Endoribonuclease L-PSP; KEGG: atc:AGR_C_2721 hypothetical protein YP_001178229.1 PFAM: regulatory protein, TetR; KEGG: ret:RHE_CH00601 probable transcriptional regulator protein, TetR family YP_001178231.1 KEGG: ssn:SSO_1350 hypothetical protein YP_001178232.1 PFAM: heat shock protein DnaJ domain protein; KEGG: sec:SC0604 ATPase involved in DNA repair YP_001178233.1 PFAM: Siderophore-interacting protein; FAD-binding 9, siderophore-interacting domain protein; KEGG: ecc:c3823 hypothetical protein YqjH YP_001178234.1 PFAM: transcriptional regulator PadR family protein; KEGG: stm:STM3215 transcriptional regulator YP_001178235.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; KEGG: stm:STM3216 methyl-accepting chemotaxis protein YP_001178236.1 KEGG: sec:SC3163 aerotaxis sensor receptor, senses cellular redox state or proton motive force; TIGRFAM: PAS sensor protein; PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; PAS fold-3 domain protein; SMART: PAC repeat-containing protein YP_001178237.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate YP_001178238.1 PFAM: helix-turn-helix domain protein; Cupin 2, conserved barrel domain protein; KEGG: aha:AHA_2538 transcriptional regulator, Cro/CI family YP_001178239.1 PFAM: B3/4 domain protein; KEGG: aha:AHA_2537 hypothetical protein YP_001178240.1 PFAM: Antibiotic biosynthesis monooxygenase; KEGG: yen:YE0523 hypothetical protein YP_001178241.1 PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: plu:plu3147 hypothetical protein YP_001178242.1 KEGG: yen:YE0525 periplasmic solute-binding protein YP_001178243.1 PFAM: inner-membrane translocator; KEGG: sfv:SFV_1570 transport system permease YP_001178244.1 PFAM: inner-membrane translocator; KEGG: stt:t3543 ABC transporter permease YP_001178245.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: yen:YE0528 ABC transporter ATP-binding protein YP_001178246.1 PFAM: sugar-binding domain protein; KEGG: plu:plu3142 LsrR DNA-binding protein YP_001178247.1 PFAM: carbohydrate kinase, FGGY; KEGG: yps:YPTB0554 hypothetical protein YP_001178248.1 PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: ecp:ECP_3172 2,4-dienoyl-CoA reductase YP_001178249.1 PFAM: methyltransferase small; Methyltransferase type 12; KEGG: ecs:ECs3966 ribosomal RNA small subunit methyltransferase D YP_001178250.1 PFAM: protein of unknown function DUF45; KEGG: sdy:SDY_3268 hypothetical protein YP_001178251.1 PFAM: oxidoreductase domain protein; KEGG: ssn:SSO_3118 hypothetical protein YP_001178252.1 PFAM: Integral membrane protein TerC; KEGG: stm:STM3224 tellurite resistance protein YP_001178253.1 involved in the import of serine and threonine coupled with the import of sodium YP_001178254.1 PFAM: D-galactarate dehydratase/Altronate hydrolase domain protein; SAF domain; KEGG: ssn:SSO_3244 altronate hydrolase YP_001178255.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism YP_001178256.1 TIGRFAM: d-galactonate transporter; PFAM: major facilitator superfamily MFS_1; KEGG: ecv:APECO1_3326 hexuronate transporter ExuT YP_001178257.1 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization. YP_001178258.1 KEGG: stt:t3146 hypothetical protein YP_001178259.1 KEGG: sfv:SFV_3140 hypothetical protein YP_001178260.1 PFAM: protein of unknown function DUF1090; KEGG: sbo:SBO_2964 hypothetical protein YP_001178261.1 PFAM: protein of unknown function DUF883, ElaB; KEGG: spt:SPA3098 hypothetical protein YP_001178262.1 KEGG: stm:STM3230 inner membrane protein YP_001178263.1 KEGG: stm:STM3231 inner membrane protein YP_001178264.1 PFAM: DoxX family protein; KEGG: ecv:APECO1_3319 hypothetical protein YP_001178265.1 KEGG: ecv:APECO1_3318 glutathione S-transferase YP_001178266.1 PFAM: protein of unknown function DUF805; KEGG: sbo:SBO_2970 cytochrome YP_001178267.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: sfv:SFV_3148 transcriptional regulator LysR-type YP_001178268.1 PFAM: Pirin domain protein domain protein; KEGG: ecv:APECO1_3315 pirin-related protein YP_001178269.1 KEGG: stm:STM0307 VirG-like protein YP_001178270.1 KEGG: sbo:SBO_2979 probable formate acetyltransferase 3; TIGRFAM: formate acetyltransferase; PFAM: formate C-acetyltransferase glycine radical; pyruvate formate-lyase, PFL YP_001178271.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism YP_001178272.1 involved in the import of threonine and serine in combination with the import of a proton YP_001178273.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic YP_001178274.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation YP_001178275.1 PFAM: glycerate kinase; KEGG: sfx:S3376 glycerate kinase YP_001178276.1 catalyzes the reduction of tartronate semialdehyde to glycerate YP_001178277.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate YP_001178278.1 TIGRFAM: d-galactonate transporter; PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: ecv:APECO1_3300 (D)-galactarate transporter YP_001178279.1 PFAM: D-galactarate dehydratase/Altronate hydrolase domain protein; SAF domain; KEGG: ecv:APECO1_3299 D-galactarate dehydratase YP_001178280.1 transcriptional repressor for the agaZVWA and agaSYBCDI operons YP_001178281.1 PFAM: D-tagatose-bisphosphate aldolase class II accessory protein AgaZ; KEGG: ecv:APECO1_3297 tagatose 6-phosphate kinase 2 YP_001178282.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport YP_001178283.1 PFAM: phosphotransferase system PTS, sorbose-specific IIC subunit; KEGG: ecv:APECO1_3295 phosphotransferase system enzyme subunit YP_001178284.1 PFAM: PTS system mannose/fructose/sorbose family IID component; KEGG: ecv:APECO1_3294 PTS system, N-acetylgalactosamine-specific IID component YP_001178285.1 PFAM: PTS system fructose subfamily IIA component; KEGG: ecv:APECO1_3293 phosphotransferase system enzyme subunit YP_001178286.1 PFAM: sugar isomerase (SIS); KEGG: ecv:APECO1_3291 tagatose-6-phosphate ketose/aldose isomerase YP_001178287.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway YP_001178288.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport YP_001178289.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport YP_001178290.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport YP_001178291.1 PFAM: glucosamine/galactosamine-6-phosphate isomerase; KEGG: ecc:c3898 galactosamine-6-phosphate isomerase YP_001178292.1 PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: stt:t3183 conserved hypothetical protein YP_001178293.1 PFAM: LppC family lipoprotein; KEGG: stm:STM3264 paral transglycosylase YP_001178294.1 PFAM: protein of unknown function UPF0102; KEGG: sdy:SDY_3327 hypothetical protein YP_001178295.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein YP_001178296.1 PFAM: transport-associated; SMART: Transport-associated and nodulation region, bacteria; KEGG: stm:STM3267 periplasmic protein YP_001178297.1 PFAM: permease; KEGG: ecs:ECs4032 hypothetical protein YP_001178298.1 PFAM: NAD-dependent epimerase/dehydratase; KEGG: ecv:APECO1_3278 hypothetical protein YP_001178299.1 TIGRFAM: intracellular protease, PfpI family; PFAM: ThiJ/PfpI domain protein; KEGG: sdy:SDY_3332 hypothetical protein YP_001178300.1 KEGG: ecs:ECs4035 hypothetical protein YP_001178301.1 PFAM: Excinuclease ABC, C subunit domain protein; KEGG: sec:SC3212 hypothetical protein YP_001178302.1 PFAM: GCN5-related N-acetyltransferase; KEGG: stm:STM3272 ABC superfamily (membrane) transport protein YP_001178303.1 PFAM: Sterol-binding domain protein; KEGG: ecp:ECP_3245 hypothetical protein YhbT YP_001178304.1 PFAM: peptidase U32; KEGG: ssn:SSO_3304 collagenase YP_001178305.1 PFAM: peptidase U32; KEGG: ecs:ECs4040 hypothetical protein YP_001178306.1 PFAM: luciferase family protein; KEGG: sec:SC3217 alkanal monooxygenase YP_001178307.1 tryptophan transporter of high affinity YP_001178308.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division YP_001178309.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing YP_001178310.1 KEGG: ecv:APECO1_3266 polynucleotide phosphorylase/polyadenylase; PFAM: 3' exoribonuclease; RNA binding S1 domain protein; KH, type 1, domain protein; SMART: KH domain protein YP_001178311.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_001178312.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_001178313.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_001178314.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001178315.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001178316.2 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_001178317.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis YP_001178318.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_001178319.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate YP_001178320.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins YP_001178321.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit YP_001178322.1 RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability YP_001178323.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001178324.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_001178325.1 response regulator in two-component regulatory system with BasS YP_001178326.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; KEGG: yps:YPTB0468 two-component system sensor protein YP_001178327.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001178328.1 PFAM: protein of unknown function DUF6, transmembrane; Protein of unknown function DUF250; KEGG: sbo:SBO_3198 hypothetical protein YP_001178329.1 involved in the peptidyltransferase reaction during translation YP_001178330.1 PFAM: ribosomal protein L21; KEGG: sdy:SDY_3367 50S ribosomal subunit protein L21 YP_001178331.1 PFAM: Polyprenyl synthetase; KEGG: stm:STM3305 octaprenyl diphosphate synthase YP_001178332.1 activator of maltose metabolism genes YP_001178333.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001178334.1 PFAM: BolA family protein; KEGG: stm:STM3308 transcriptional regulator YP_001178335.1 KEGG: stm:STM3309 STAS domain YP_001178336.1 PFAM: toluene tolerance family protein; KEGG: stm:STM3310 ABC superfamily (atp&memb), transport protein YP_001178337.1 PFAM: Mammalian cell entry related domain protein; KEGG: stm:STM3311 ABC superfamily (bind_prot) transport protein YP_001178338.1 PFAM: protein of unknown function DUF140; KEGG: stm:STM3312 ABC superfamily (membr) transport protein YP_001178339.1 ATP-binding subunit of a ABC toluene efflux transporter YP_001178340.1 YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers YP_001178341.1 KEGG: stm:STM3315 sugar phosphate isomerase; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS) YP_001178342.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis YP_001178343.1 PFAM: protein of unknown function DUF1239; KEGG: stm:STM3317 inner membrane protein YP_001178344.1 LptA; periplasmic binding protein part of a ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system YP_001178345.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: stm:STM3319 ABC superfamily (atp_bind) transport protein YP_001178346.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_001178347.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing YP_001178348.1 TIGRFAM: PTS IIA-like nitrogen-regulatory protein PtsN; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; KEGG: stm:STM3322 sugar specific PTS family, enzyme IIA, also regulates N metabolism YP_001178349.1 PFAM: uncharacterised P-loop ATPase UPF0042; KEGG: stm:STM3323 P-loop-containing kinase YP_001178350.1 TIGRFAM: phosphocarrier, HPr family; PFAM: phosphocarrier HPr protein; KEGG: stm:STM3324 NPr, phosphocarrier protein HPr-like NPr, nitrogen related, exchanges phosphate with Enzyme I YP_001178351.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan YP_001178352.1 PFAM: ThiJ/PfpI domain protein; KEGG: sfv:SFV_3239 sigma cross-reacting protein 27A (SCRP-27A) YP_001178353.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA YP_001178354.1 PFAM: permease YjgP/YjgQ family protein; KEGG: ecp:ECP_4511 membrane protein YjgQ YP_001178355.1 PFAM: permease YjgP/YjgQ family protein; KEGG: sec:SC4335 permease YP_001178356.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_001178357.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_001178358.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001178359.1 PFAM: GCN5-related N-acetyltransferase; KEGG: stt:t4508 acetyltransferase YP_001178360.1 PFAM: alanine dehydrogenase/PNT domain protein; Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: ecp:ECP_4519 hypothetical zinc-type alcohol dehydrogenase-like protein YjgB YP_001178361.1 KEGG: rle:RL2900 dihydroxyacetone kinase; TIGRFAM: dihydroxyacetone kinase; PFAM: Dak kinase; Dak phosphatase YP_001178362.1 PFAM: protein of unknown function DUF853, NPT hydrolase KEGG: ecp:ECP_4512 hypothetical protein YjgR YP_001178363.1 KEGG: ecv:APECO1_3224 Fe-S oxidoreductase; TIGRFAM: conserved hypothetical radical SAM protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001178364.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate YP_001178365.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_001178366.1 PFAM: conserved hypothetical protein 22; KEGG: sdy:SDY_3396 hypothetical protein YP_001178367.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein YP_001178368.1 TIGRFAM: sialic acid transporter; PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: ecc:c3978 sialic acid transporter YP_001178369.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid YP_001178370.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization YP_001178371.1 PFAM: Stringent starvation protein B; KEGG: stm:STM3341 stringent starvation protein B YP_001178372.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation YP_001178373.1 forms a direct contact with the tRNA during translation YP_001178374.2 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001178375.1 PFAM: AFG1-family ATPase; KEGG: ecv:APECO1_3212 hypothetical protein YP_001178376.1 PFAM: protein of unknown function DUF1043; KEGG: stm:STM3347 periplasmic protein YP_001178377.1 TIGRFAM: protease Do; PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: spt:SPA3215 serine protease YP_001178378.1 TIGRFAM: periplasmic serine protease DegS; PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: ecp:ECP_3318 protease DegS precursor YP_001178379.1 oxidizes malate to oxaloacetate YP_001178380.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_001178381.1 PFAM: protein of unknown function DUF1471; KEGG: sbo:SBO_3151 hypothetical protein YP_001178382.1 PFAM: protein of unknown function DUF1471; KEGG: stm:STM3362 periplasmic protein YP_001178383.1 KEGG: sbo:SBO_3150 hypothetical protein YP_001178384.1 KEGG: eca:ECA0280 succinate-semialdehyde dehydrogenase [NADP+]; TIGRFAM: succinic semialdehyde dehydrogenase; PFAM: aldehyde dehydrogenase YP_001178385.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate YP_001178386.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate YP_001178387.1 membrane protein AaeX; the gene is a member of the aaeXAB operon YP_001178388.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: sbo:SBO_3144 QseA YP_001178389.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA YP_001178390.1 KEGG: stm:STM3369 protease YP_001178391.1 involved in the processing of the 5'end of 16S rRNA YP_001178392.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_001178393.1 part of cell wall structural complex MreBCD; transmembrane component YP_001178394.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_001178395.1 functions in MreBCD complex in some organisms YP_001178396.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules YP_001178397.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: ecp:ECP_3337 probable zinc-binding dehydrogenase YP_001178398.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_001178399.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme YP_001178400.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_001178401.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001178402.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001178403.1 PFAM: protein of unknown function DUF997; KEGG: stm:STM3381 inner membrane protein YP_001178404.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase YP_001178405.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_001178406.1 PFAM: carbonic anhydrase; KEGG: eca:ECA0257 carbonic anhydrase YP_001178407.1 TIGRFAM: TIM-barrel protein, nifR3 family; PFAM: dihydrouridine synthase, DuS; dihydroorotate dehydrogenase; KEGG: stm:STM3384 TIM-barrel enzyme, possibly dehydrogenase YP_001178408.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription YP_001178409.1 KEGG: stm:STM3387 periplasmic protein YP_001178410.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; MHYT domain protein; KEGG: spt:SPA3255 membrane domain involved in signal transduction; diguanylate cyclase/phosphodiesterase domain 1; diguanylate cyclase/phosphodiesterase domain 2 YP_001178411.1 PFAM: regulatory protein, TetR; Tetracycline transcriptional repressor MAATS-type, C-terminal domain protein; KEGG: sec:SC3326 transcriptional repressor for envCD (acrEF) (TetR/AcrR family) YP_001178412.1 TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; KEGG: stm:STM3390 transmembrane protein affecting septum formation and cell membrane permeability YP_001178413.1 TIGRFAM: transporter, hydrophobe/amphiphile efflux-1 (HAE1) family; PFAM: acriflavin resistance protein; KEGG: stm:STM3391 RND family, multidrug transport protein, acriflavin resistance protein F YP_001178414.1 KEGG: ecs:ECs4140 hypothetical protein YP_001178415.1 PFAM: extracellular solute-binding protein, family 3; KEGG: ecs:ECs4141 periplasmic binding transport protein YP_001178416.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ecp:ECP_3364 hypothetical amino-acid ABC transporter permease YhdX YP_001178417.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ecp:ECP_3365 hypothetical amino-acid ABC transporter permease YhdY YP_001178418.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: ecs:ECs4144 ATP-binding component of a transport system YP_001178419.1 KEGG: ssn:SSO_3420 transferase YP_001178420.1 PFAM: protein of unknown function DUF1488; KEGG: ssn:SSO_3421 hypothetical protein YP_001178421.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_001178422.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA YP_001178423.1 PFAM: DNA topoisomerase, type IA, zn finger domain protein; KEGG: sdy:SDY_3460 DNA topoisomerase YP_001178424.1 PFAM: protein of unknown function DUF494; KEGG: stm:STM3404 Smg protein YP_001178425.1 TIGRFAM: DNA protecting protein DprA; PFAM: SMF family protein; KEGG: ecs:ECs4151 DNA processing chain A YP_001178426.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001178427.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_001178428.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase YP_001178429.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_001178430.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_001178431.1 PFAM: protein of unknown function DUF331; KEGG: stm:STM3411 cytoplasmic protein YP_001178432.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators YP_001178433.1 is a component of the macrolide binding site in the peptidyl transferase center YP_001178434.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001178435.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001178436.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001178437.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_001178438.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_001178439.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001178440.1 late assembly protein YP_001178441.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001178442.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001178443.1 binds 5S rRNA along with protein L5 and L25 YP_001178444.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001178445.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001178446.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001178447.1 PFAM: ribosomal protein L5; KEGG: stm:STM3428 50S ribosomal subunit protein L5 YP_001178448.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001178449.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001178450.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001178451.1 PFAM: ribosomal protein L29; KEGG: yps:YPTB3690 50S ribosomal protein L29 YP_001178452.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001178453.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001178454.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001178455.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001178456.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001178457.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001178458.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001178459.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001178460.1 PFAM: ribosomal protein S10; KEGG: sgl:SG2279 30S ribosomal protein S10 YP_001178461.1 iron storage protein YP_001178462.1 PFAM: BFD domain protein [2Fe-2S]-binding domain protein; KEGG: stm:STM3444 Bacterioferritin-associated ferredoxin YP_001178463.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001178464.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001178465.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001178466.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_001178467.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_001178468.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_001178469.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_001178470.1 PFAM: YheO domain protein; KEGG: sbo:SBO_3326 hypothetical protein YP_001178471.1 rotamase YP_001178472.1 PFAM: SlyX family protein; KEGG: stm:STM3454 cytoplasmic protein YP_001178473.1 rotamase YP_001178474.1 KEGG: sdy:SDY_3511 hypothetical protein YP_001178475.1 involved in potassium efflux YP_001178476.1 required for KefB activity YP_001178477.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: sbo:SBO_3332 ATP-binding component of a transport system YP_001178478.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: pna:Pnap_0955 transcriptional regulator, LysR family YP_001178479.1 PFAM: acyl transferase domain protein; KEGG: pst:PSPTO_5081 malonyl CoA-acyl carrier protein transacylase YP_001178480.1 Catalyzes the transfer of 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A to the apo-acyl carrier protein of malonate dehydrogenase to form holo-acyl carrier protein YP_001178481.1 TIGRFAM: auxin efflux carrier; PFAM: Auxin Efflux Carrier; KEGG: bja:bll0264 probable malonate decarboxylase subunit YP_001178482.1 PFAM: malonate decarboxylase gamma subunit; KEGG: psp:PSPPH_0437 malonate decarboxylase, gamma subunit YP_001178483.1 The beta subunit catalyzes the decarboxylation of the malonyl moiety on coenzyme A YP_001178484.1 PFAM: malonate decarboxylase delta subunit; KEGG: pau:PA14_02570 malonate decarboxylase delta subunit YP_001178485.1 PFAM: triphosphoribosyl-dephospho-CoA protein; KEGG: pfo:Pfl_5301 triphosphoribosyl-dephospho-CoA protein YP_001178486.1 TIGRFAM: malonate decarboxylase, alpha subunit; KEGG: pna:Pnap_0946 malonate decarboxylase alpha subunit YP_001178487.1 PFAM: alpha/beta hydrolase fold; KEGG: sec:SC3396 hydrolase alpha/beta-hydrolase fold YP_001178488.1 PFAM: protein of unknown function UPF0270; KEGG: sbo:SBO_3334 hypothetical protein YP_001178489.1 PFAM: phosphoribulokinase/uridine kinase; KEGG: stm:STM3464 phosphoribulokinase YP_001178490.1 PFAM: OsmC family protein; KEGG: sdy:SDY_3518 hypothetical protein YP_001178491.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons YP_001178492.1 TIGRFAM: integral membrane protein, YccS/YhfK family; PFAM: protein of unknown function DUF893, YccS/YhfK; KEGG: spt:SPA3333 inner membrane protein YP_001178493.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate YP_001178494.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity YP_001178495.1 PFAM: filamentation induced by cAMP protein Fic; KEGG: spt:SPA3336 cell filamentation protein Fic YP_001178496.1 PFAM: peptidyl-prolyl cis-trans isomerase, cyclophilin type; KEGG: stm:STM3472 peptidyl-prolyl cis-trans isomerase A (rotamase A) YP_001178497.1 PFAM: major facilitator superfamily MFS_1; KEGG: stt:t4032 membrane protein YP_001178498.1 Catalyzes the deamination of cytosine to uracil and ammonia YP_001178499.1 TIGRFAM: nitrite reductase [NAD(P)H], large subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region; BFD domain protein [2Fe-2S]-binding domain protein; KEGG: stt:t4031 nitrite reductase large subunit YP_001178500.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations YP_001178501.1 member of the FNT family of formate and nitrite transporters YP_001178502.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin YP_001178503.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001178504.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_001178505.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_001178506.1 KEGG: spt:SPA3349 DNA adenine methylase; TIGRFAM: DNA adenine methylase; PFAM: D12 class N6 adenine-specific DNA methyltransferase YP_001178507.1 PFAM: Sporulation domain protein; KEGG: stm:STM3485 membrane protein YP_001178508.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_001178509.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_001178510.2 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa YP_001178511.1 KEGG: ssn:SSO_3523 hypothetical protein YP_001178512.1 KEGG: spt:SPA3355 hypothetical protein YP_001178513.1 PFAM: Fimbrial assembly family protein; KEGG: stm:STM3491 inner membrane protein YP_001178514.1 KEGG: stt:t4014 hypothetical protein YP_001178515.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits YP_001178516.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_001178517.1 PFAM: Intracellular growth attenuator IgaA; KEGG: stm:STM3495 inner membrane protein YP_001178518.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: stm:STM3496 hydrolase YP_001178519.1 PFAM: RNA-binding S4 domain protein; KEGG: sdy:SDY_3678 hypothetical protein YP_001178520.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_001178521.1 KEGG: ecj:JW3365 predicted inner membrane protein YP_001178522.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_001178523.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR YP_001178524.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation YP_001178525.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001178526.1 PFAM: RNA binding S1 domain protein; SMART: Resolvase, RNase H domain protein fold; KEGG: ecc:c4184 protein YhgF YP_001178527.1 PFAM: FeoA family protein; KEGG: sdy:SDY_3668 ferrous iron transport protein A YP_001178528.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake YP_001178529.1 KEGG: sec:SC3439 cytoplasmic protein YP_001178530.1 PFAM: protein of unknown function DUF1471; KEGG: yps:YPTB3770 hypothetical protein YP_001178531.1 TIGRFAM: bioH protein; PFAM: alpha/beta hydrolase fold; KEGG: ecj:JW3375 carboxylesterase of pimeloyl-CoA synthesis YP_001178532.1 involved in high-affinity gluconate transport YP_001178533.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source YP_001178534.1 TIGRFAM: gluconate transporter; PFAM: Gluconate transporter; Citrate transporter; KEGG: spt:SPA3377 high-affinity gluconate transporter YP_001178535.1 amylomaltase; acts to release glucose from maltodextrins YP_001178536.1 KEGG: stm:STM3514 maltodextrin phosphorylase; TIGRFAM: glycogen/starch/alpha-glucan phosphorylase; PFAM: glycosyl transferase, family 35 YP_001178537.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides YP_001178538.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism YP_001178539.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity YP_001178540.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine YP_001178541.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_001178542.1 KEGG: sec:SC3464 glycogen phosphorylase; TIGRFAM: glycogen/starch/alpha-glucan phosphorylase; PFAM: glycosyl transferase, family 35 YP_001178543.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_001178544.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_001178545.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen YP_001178546.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_001178547.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001178548.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP) YP_001178549.1 KEGG: stt:t4363 hypothetical protein YP_001178550.1 TIGRFAM: gluconate transporter; PFAM: Gluconate transporter; Citrate transporter; KEGG: stm:STM3541 low affinity gluconate permease YP_001178551.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate YP_001178552.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: sec:SC3473 transcriptional repressor gnt-I, gntUKR (GalR/LacI familiy) YP_001178553.1 PFAM: Pirin domain protein domain protein; Cupin 2, conserved barrel domain protein; KEGG: stm:STM3544 cytoplasmic protein YP_001178554.1 PFAM: oxidoreductase domain protein; Oxidoreductase, C-terminal domain; KEGG: stm:STM3545 oxidoreductase YP_001178555.1 PFAM: GCN5-related N-acetyltransferase; KEGG: spt:SPA3398 acetyltransferase YP_001178556.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides YP_001178557.1 KEGG: sdy:SDY_3596 hypothetical protein YP_001178558.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate YP_001178559.1 part of the UgpABCE glycerol-3-phosphate uptake system YP_001178560.1 with UgpABC is involved in uptake of glycerol-3-phosphate YP_001178561.1 with UgpEC is involved in the uptake of glycerol-3-phosphate YP_001178562.1 with UgpACE is involved in the uptake of glycerol-3-phosphate YP_001178563.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_001178564.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_001178565.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_001178566.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter YP_001178567.1 PFAM: Extracellular ligand-binding receptor; KEGG: sbo:SBO_3453 high-affinity leucine-specific transport system periplasmic binding protein YP_001178568.1 PFAM: GCN5-related N-acetyltransferase; KEGG: spt:SPA3416 hypothetical protein YP_001178569.1 PFAM: Extracellular ligand-binding receptor; KEGG: sbo:SBO_3457 high-affinity amino acid transport system periplasmic binding protein YP_001178570.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_001178571.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_001178572.1 ABC transporter, membrane protein YP_001178573.1 ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions YP_001178574.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins YP_001178575.1 catalyzes the methylation of 16S rRNA at position G966 YP_001178576.1 PFAM: protein of unknown function DUF1145; KEGG: sdy:SDY_3617 hypothetical protein YP_001178577.1 KEGG: sbo:SBO_3464 receptor YP_001178578.1 PFAM: YhhN family protein; KEGG: stm:STM3575 inner membrane protein YP_001178579.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury YP_001178580.1 TIGRFAM: TRAP dicarboxylate transporter, DctM subunit; PFAM: Citrate transporter; TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: yps:YPTB1604 TRAP-T family C4-dicarboxylate transporter, large (DctM) subunit YP_001178581.1 PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component; KEGG: eca:ECA0356 hypothetical protein YP_001178582.1 TIGRFAM: TRAP dicarboxylate transporter, DctP subunit; PFAM: TRAP dicarboxylate transporter- DctP subunit; KEGG: eca:ECA0357 substrate-binding periplasmic protein YP_001178583.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs YP_001178584.1 TIGRFAM: conserved hypothetical integral membrane protein; PFAM: protein of unknown function DUF165; KEGG: sfx:S4274 hypothetical protein YP_001178585.1 KEGG: sdy:SDY_3623 hypothetical protein YP_001178586.1 PFAM: major facilitator superfamily MFS_1; KEGG: ecv:APECO1_2981 hypothetical protein YP_001178587.1 PFAM: protein of unknown function UPF0118; KEGG: sfv:SFV_3477 hypothetical protein YP_001178588.1 KEGG: ece:Z4849 hypothetical protein YP_001178589.1 PFAM: O-methyltransferase, family 2; Methyltransferase type 12; KEGG: ece:Z4850 O-methyltransferase YP_001178590.1 KEGG: ece:Z4851 hypothetical protein YP_001178591.1 PFAM: phospholipid/glycerol acyltransferase; KEGG: ecc:c1201 phospholipid biosynthesis acyltransferase YP_001178592.1 KEGG: ecs:ECs4328 acyl carrier protein YP_001178593.1 carries the fatty acid chain in fatty acid biosynthesis YP_001178594.1 KEGG: ecs:ECs4330 hypothetical membrane protein YP_001178595.1 PFAM: AMP-dependent synthetase and ligase; KEGG: ecs:ECs4331 surfactin synthetase YP_001178596.1 KEGG: ecs:ECs4332 (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase YP_001178597.1 PFAM: glycosyl transferase, family 2; KEGG: ecs:ECs4333 hypothetical protein YP_001178598.1 PFAM: thioesterase superfamily protein; KEGG: ecc:c1193 hypothetical protein YP_001178599.1 PFAM: outer membrane lipoprotein carrier protein LolA; KEGG: ecs:ECs4335 hypothetical protein YP_001178600.1 KEGG: ecs:ECs4336 hypothetical membrane protein YP_001178601.1 KEGG: ecs:ECs4337 hypothetical lipoprotein YP_001178602.1 FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001178603.1 KEGG: ecc:c1188 hypothetical protein YP_001178604.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001178605.1 FabB; beta-ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001178606.1 PFAM: 4'-phosphopantetheinyl transferase; KEGG: stm:STM3583 phosphopantetheinyl transferase YP_001178607.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR; KEGG: bte:BTH_II1694 D-beta-hydroxybutyrate dehydrogenase YP_001178608.1 PFAM: NLP/P60 protein; KEGG: csa:Csal_1293 NLP/P60 YP_001178609.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; KEGG: pfl:PFL_3432 HAD-superfamily hydrolase, subfamily IB YP_001178610.1 PFAM: Integral membrane protein TerC; KEGG: ecs:ECs1354 tellurium resistance protein TerC YP_001178611.1 PFAM: Ion transport 2 domain protein,; KEGG: mmr:Mmar10_1749 ion transport 2 domain protein YP_001178612.1 PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; HI0933 family protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: ecs:ECs4364 hypothetical protein YP_001178613.1 PFAM: phosphate transporter; KEGG: stm:STM3589 PiT family, low-affinity phosphate transporter YP_001178614.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress YP_001178615.1 PFAM: UspA domain protein; KEGG: sdy:SDY_3567 universal stress protein; broad regulatory function? YP_001178616.1 predicted SAM-dependent methyltransferase YP_001178617.1 PFAM: peptidase M3A and M3B, thimet/oligopeptidase F; KEGG: stm:STM3594 oligopeptidase A YP_001178618.1 PFAM: protein of unknown function DUF519; KEGG: ecs:ECs4371 hypothetical protein YP_001178619.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_001178620.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose YP_001178621.1 KEGG: stm:STM3604 inner membrane protein YP_001178622.1 PFAM: GCN5-related N-acetyltransferase; KEGG: yen:YE1230 acetyltransferase YP_001178623.1 PFAM: short-chain dehydrogenase/reductase SDR; KR; KEGG: ajs:Ajs_0159 short-chain dehydrogenase/reductase SDR YP_001178624.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: stm:STM3607 transcriptional regulator YP_001178625.1 TIGRFAM: ribonuclease; PFAM: ribonuclease BN; KEGG: stm:STM3608 tRNA-processing ribonuclease YP_001178626.1 TIGRFAM: metabolite/H+ symporter, major facilitator superfamily (MFS); PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: stm:STM3609 transport protein YP_001178627.1 PFAM: AsmA family protein; KEGG: ece:Z4937 hypothetical protein YP_001178628.1 in Escherichia coli this protein is involved in flagellar function YP_001178629.1 PFAM: PfkB domain protein; KEGG: ecj:JW5668 ketodeoxygluconokinase YP_001178630.1 PFAM: peptidase M16 domain protein; KEGG: stm:STM3613 Zn-dependent peptidase YP_001178631.1 involved in the transport of C4-dicarboxylates across the membrane YP_001178632.2 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a phosphodiesterase from E. coli YP_001178633.1 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA YP_001178634.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans YP_001178635.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP) YP_001178636.1 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis YP_001178637.1 PFAM: YhjQ family protein; KEGG: stm:STM3620 chromosome partitioning ATPase YP_001178638.1 KEGG: stm:STM3621 cytoplasmic protein YP_001178639.1 KEGG: stm:STM3622 cytoplasmic protein YP_001178640.1 KEGG: stm:STM3623 inner membrane protein YP_001178641.1 KEGG: ecv:APECO1_2913 hypothetical protein YP_001178642.1 PFAM: glycoside hydrolase, family 8; KEGG: zmo:ZMO1086 endoglucanase Y YP_001178643.1 KEGG: bxe:Bxe_B2037 hypothetical protein YP_001178644.1 PFAM: TPR repeat-containing protein; cellulose synthase operon C domain protein; SMART: Tetratricopeptide domain protein; KEGG: xac:XAC3515 cellulose synthase subunit C YP_001178645.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP) YP_001178646.1 PFAM: glycosyl transferase, family 2; type IV pilus assembly PilZ; KEGG: zmo:ZMO1083 glycosyltransferase YP_001178647.1 KEGG: bxe:Bxe_B2039 hypothetical protein YP_001178649.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_001178650.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001178651.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX YP_001178652.1 TIGRFAM: potassium uptake protein, TrkH family; PFAM: cation transporter; KEGG: stm:STM3986 Trk family, potassium transport protein, requires TrkE YP_001178653.1 PFAM: protein of unknown function UPF0029; KEGG: sec:SC3882 cytoplasmic protein YP_001178654.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters YP_001178655.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_001178656.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_001178657.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin YP_001178658.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol YP_001178659.1 KEGG: stt:t3320 transcriptional activator; TIGRFAM: transcriptional activator RfaH; PFAM: transcription antitermination protein NusG; SMART: NGN domain protein YP_001178660.1 magnesium dependent; not involved in the Sec-independent protein export system YP_001178661.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane YP_001178662.1 mediates the export of protein precursors bearing twin-arginine signal peptides YP_001178663.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_001178664.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions YP_001178665.1 PFAM: protein of unknown function DUF1243; KEGG: sbo:SBO_3848 hypothetical protein YP_001178666.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_001178667.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner YP_001178668.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway YP_001178669.1 PFAM: dienelactone hydrolase; KEGG: sfl:SF3908 carboxymethylenebutenolidase YP_001178670.1 TIGRFAM: PTS system, glucose subfamily, IIA subunit; PTS system, beta-glucoside-specific IIABC subunit; PFAM: sugar-specific permease, EIIA 1 domain; phosphotransferase system PTS, EIIB protein; phosphotransferase system, EIIC; KEGG: bld:BLi00748 close homolog to BglP PTS enzyme IIBCA component; RBL02795 YP_001178671.1 PFAM: glycoside hydrolase, family 1; KEGG: bld:BLi00749 close homolog to BglH beta-glucosidase; RBL02794 YP_001178672.1 PFAM: CAT RNA-binding domain protein; PRD domain protein; KEGG: bld:BLi00750 hypothetical protein YP_001178673.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_001178674.1 PFAM: regulatory protein, LysR; LysR, substrate-binding; KEGG: sbo:SBO_3840 MetR YP_001178675.1 TIGRFAM: carboxylate/amino acid/amine transporter; PFAM: protein of unknown function DUF6, transmembrane; KEGG: ecc:c4749 hypothetical membrane protein YigM YP_001178676.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium YP_001178677.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates YP_001178678.1 TIGRFAM: homoserine/threonine efflux pump; PFAM: Lysine exporter protein (LYSE/YGGA); KEGG: spt:SPA3801 homoserine/homoserine lactone efflux protein YP_001178679.1 TIGRFAM: homoserine/threonine efflux pump; PFAM: Lysine exporter protein (LYSE/YGGA); KEGG: sec:SC3858 RhtB family, threonine efflux protein YP_001178680.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway YP_001178681.1 catalyzes the hydrolysis of phosphatidylcholine YP_001178682.1 PFAM: thioesterase superfamily protein; KEGG: stm:STM3956 protein PaaI, possibly involved in aromatic compounds catabolism YP_001178683.1 TIGRFAM: RarD protein, DMT superfamily transporter; PFAM: protein of unknown function DUF6, transmembrane; KEGG: sec:SC3854 chloramphenicol resistance YP_001178684.1 responsible for the influx of magnesium ions YP_001178685.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. YP_001178686.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function YP_001178687.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001178688.1 PFAM: protein of unknown function DUF484; KEGG: stt:t3349 hypothetical protein YP_001178689.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_001178690.1 KEGG: stm:STM3946 outer membrane lipoprotein YP_001178691.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly YP_001178692.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP YP_001178693.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_001178694.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis YP_001178695.1 PFAM: protein of unknown function DUF513, hemX; KEGG: ssn:SSO_3975 uroporphyrinogen III methylase YP_001178696.1 TIGRFAM: HemY protein; PFAM: HemY domain protein; Tetratricopeptide TPR_2 repeat protein; KEGG: sbo:SBO_3813 HemY YP_001178698.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function YP_001178699.1 TIGRFAM: glycosyl transferase, WecB/TagA/CpsF family; PFAM: glycosyl transferase WecB/TagA/CpsF; KEGG: ecj:JW3770 UDP-N-acetyl-D-mannosaminuronic acid transferase YP_001178700.1 enterobacterial common antigen polymerase YP_001178701.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis YP_001178702.1 PFAM: polysaccharide biosynthesis protein; KEGG: stt:t3371 lipopolysaccharide biosynthesis protein YP_001178703.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis YP_001178704.1 TIGRFAM: TDP-D-fucosamine acetyltransferase; PFAM: GCN5-related N-acetyltransferase; KEGG: ecv:APECO1_2685 lipopolysaccharide biosynthesis protein RffC YP_001178705.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid YP_001178706.1 PFAM: UDP-N-acetylglucosamine 2-epimerase; KEGG: ecc:c4706 UDP-N-acetylglucosamine 2-epimerase YP_001178707.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein YP_001178708.1 TIGRFAM: undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; PFAM: glycosyl transferase, family 4; KEGG: ssn:SSO_3956 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase YP_001178709.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001178710.1 TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: sdy:SDY_3968 thioredoxin 1 YP_001178711.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation YP_001178712.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation YP_001178713.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication YP_001178714.1 PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase; KEGG: stm:STM3910 peptidyl-prolyl cis-trans isomerase C (rotamase C) YP_001178715.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_001178716.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate YP_001178717.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway YP_001178718.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_001178719.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001178720.1 KEGG: sec:SC3807 acetolactate synthase II, small subunit YP_001178721.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit YP_001178722.1 among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function YP_001178723.1 PFAM: protein of unknown function DUF413; KEGG: sdy:SDY_3984 hypothetical protein YP_001178724.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon YP_001178725.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_001178726.2 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space YP_001178727.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs YP_001178728.1 PFAM: protein of unknown function DUF1422; KEGG: stm:STM4128 inner membrane protein YP_001178729.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis YP_001178730.1 catalyzes the conversion of NADPH to NADH YP_001178731.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA YP_001178732.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_001178733.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_001178734.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_001178735.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis YP_001178736.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_001178737.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone YP_001178738.1 KEGG: sec:SC3998 catalase; hydroperoxidase HPI(I); TIGRFAM: catalase/peroxidase HPI; PFAM: Haem peroxidase YP_001178739.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor YP_001178740.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_001178741.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine YP_001178742.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis YP_001178743.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001178744.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_001178745.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins YP_001178746.1 TIGRFAM: cell division protein FtsN; PFAM: Sporulation domain protein; KEGG: sdy:SDY_3804 essential cell division protein YP_001178747.1 heat shock protein involved in degradation of misfolded proteins YP_001178748.1 heat shock protein involved in degradation of misfolded proteins YP_001178749.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_001178750.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_001178751.1 PFAM: protein of unknown function DUF904; KEGG: stm:STM4088 cytoplasmic protein YP_001178752.1 TIGRFAM: MIP family channel protein; PFAM: major intrinsic protein; KEGG: stm:STM4087 MIP channel, glycerol diffusion YP_001178753.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_001178754.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_001178755.1 PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: ecs:ECs4849 ferredoxin-NADP reductase YP_001178756.1 PFAM: protein of unknown function DUF805; KEGG: ssn:SSO_4090 hypothetical protein YP_001178757.1 PFAM: protein of unknown function DUF1454; KEGG: sec:SC3971 periplasmic protein YP_001178758.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_001178759.1 PFAM: sodium/sulphate symporter; Citrate transporter; KEGG: rme:Rmet_5269 sodium/sulphate symporter YP_001178760.1 PFAM: CDP-diacylglycerol pyrophosphatase; KEGG: ecv:APECO1_2551 CDP-diacylglycerol pyrophosphatase YP_001178761.1 TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein, family 1; KEGG: stm:STM4063 ABC superfamily (bind_prot), sulfate transport protein YP_001178762.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_001178763.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers YP_001178764.1 PFAM: beta-lactamase; KEGG: eca:ECA0077 hypothetical protein YP_001178765.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates YP_001178766.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system YP_001178767.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors YP_001178768.1 PFAM: 3-alpha; MOSC domain containing protein; KEGG: stt:t3563 hypothetical protein YP_001178769.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals YP_001178770.1 transports L-rhamnose and L-lyxose into the cell YP_001178771.1 PFAM: helix-turn-helix- domain containing protein, AraC type; AraC protein, arabinose-binding/dimerisation; KEGG: stt:t3570 L-rhamnose operon transcriptional activator YP_001178772.1 activates the expression of the rhaBAD operon and rhaT gene YP_001178773.1 catalyzes the ATP-dependent phosphorylation of rhamnulose YP_001178774.1 catalyzes the formation of L-rhamnulose from L-rhamnose YP_001178775.1 KEGG: stm:STM4045 rhamnulose-1-phosphate aldolase; TIGRFAM: rhamnulose-1-phosphate aldolase; PFAM: class II aldolase/adducin family protein YP_001178776.1 TIGRFAM: rhamnose ABC transporter, periplasmic rhamnose-binding protein; PFAM: periplasmic binding protein/LacI transcriptional regulator; KEGG: sme:SMc02324 periplasmic binding ABC transporter protein YP_001178777.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: atc:AGR_L_2683 sugar ABC transporter (ATP-binding protein) YP_001178778.1 PFAM: inner-membrane translocator; KEGG: ret:RHE_PE00287 probable sugar ABC transporter, permease YP_001178779.1 PFAM: inner-membrane translocator; KEGG: sme:SMc03001 permease ABC transporter protein YP_001178780.1 TIGRFAM: lactaldehyde reductase; PFAM: iron-containing alcohol dehydrogenase; KEGG: stm:STM4044 alcohol dehydrogenase YP_001178781.1 TIGRFAM: L-rhamnose 1-epimerase; PFAM: protein of unknown function DUF718; KEGG: stm:STM4043 cytoplasmic protein YP_001178782.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments YP_001178783.1 PFAM: glycoside hydrolase, clan GH-D; KEGG: eca:ECA0754 alpha-galactosidase YP_001178784.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: eca:ECA0755 LysR-family raffinose operon repressor YP_001178785.1 PFAM: helix-turn-helix domain protein; Cupin 2, conserved barrel domain protein; KEGG: stm:STM4042A hypothetical protein YP_001178786.1 PFAM: AzlC family protein; KEGG: stm:STM4042 branched-chain amino acid permease YP_001178787.1 PFAM: branched-chain amino acid transport; KEGG: stm:STM4041 inner membrane protein YP_001178788.1 PFAM: protein of unknown function DUF1471; KEGG: ecp:ECP_3847 hypothetical protein YP_001178789.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_001178790.1 PFAM: molybdopterin oxidoreductase Fe4S4 region; KEGG: sbo:SBO_3908 formate dehydrogenase-O, major subunit YP_001178791.1 KEGG: stt:t3583 formate dehydrogenase-O major subunit; TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region YP_001178792.1 TIGRFAM: formate dehydrogenase, beta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: stm:STM4036 formate dehydrogenase-O, Fe-S subunit YP_001178793.1 cytochrome b556(FDO) component; heme containing YP_001178794.1 required for the formation of active formate dehydrogenase YP_001178795.1 PFAM: Alpha/beta hydrolase fold-3 domain protein; KEGG: ecp:ECP_4098 acetyl-hydrolase YP_001178796.1 TIGRFAM: thioesterase domain, PFAM: GCN5-related N-acetyltransferase; KEGG: stm:STM4029 acetyltransferase YP_001178797.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_001178798.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease YP_001178799.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: sbo:SBO_3899 phosphatase YP_001178800.1 TIGRFAM: small GTP-binding protein; GTP-binding protein TypA; PFAM: elongation factor G domain protein; protein synthesis factor, GTP-binding; elongation factor Tu, domain 2 protein; KEGG: eca:ECA0030 GTP-binding regulatory protein YP_001178801.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme YP_001178802.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation YP_001178803.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54 YP_001178804.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001178805.1 PFAM: protein of unknown function DUF414; KEGG: spt:SPA3844 hypothetical protein YP_001178806.1 PFAM: GTP-binding protein, HSR1-related; KEGG: ecs:ECs4787 essential GTPase for cell cycle YP_001178807.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_001178808.1 PFAM: DSBA oxidoreductase; KEGG: stm:STM3997 periplasmic protein disulfide isomerase I YP_001178809.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages YP_001178810.1 PFAM: protein of unknown function DUF1040; KEGG: sdy:SDY_3887 hypothetical protein YP_001178811.1 Links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_001178812.1 TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein B; PFAM: molybdopterin-guanine dinucleotide biosynthesis MobB region; KEGG: sec:SC3886 molybdopterin-guanine dinucleotide biosynthesis protein B, GTP-binding YP_001178813.1 PFAM: regulatory protein GntR, HTH; GntR domain protein; KEGG: sec:SC3801 regulatory protein, GntR family YP_001178814.1 TIGRFAM: drug resistance transporter, EmrB/QacA subfamily; PFAM: major facilitator superfamily MFS_1; KEGG: spt:SPA3726 MFS family tranport protein (1st mdule) YP_001178815.1 DNA-binding transcriptional repressor of ribose metabolism YP_001178816.1 catalyzes the formation of D-ribose 5-phosphate from ribose YP_001178817.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system YP_001178818.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B YP_001178819.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain YP_001178820.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source YP_001178821.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH YP_001178822.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase YP_001178823.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA YP_001178824.1 catalyzes the formation of asparagine from aspartate and ammonia YP_001178825.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase YP_001178826.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001178827.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001178828.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001178829.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation YP_001178830.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001178831.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_001178832.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_001178833.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_001178834.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001178835.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001178836.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001178837.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_001178838.1 KEGG: eca:ECA4510 exopolygalacturonate lyase YP_001178839.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_001178840.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_001178841.1 TIGRFAM: phosphate ABC transporter, periplasmic phosphate-binding protein; PFAM: extracellular solute-binding protein, family 1; KEGG: stm:STM3857 ABC superfamily (bind_prot), high-affinity phosphate transporter YP_001178842.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_001178843.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_001178844.1 KEGG: stm:STM3854 ABC superfamily (atp_bind), high-affinity phosphate transporter; TIGRFAM: phosphate ABC transporter, ATPase subunit; PFAM: ABC transporter related; SMART: AAA ATPase YP_001178845.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon YP_001178846.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily YP_001178847.1 PFAM: Xanthine/uracil/vitamin C permease; sulphate transporter; KEGG: stm:STM3851.S hypothetical protein YP_001178848.1 PFAM: NADPH-dependent FMN reductase; KEGG: spt:SPA3691 hypothetical protein YP_001178849.1 KEGG: spt:SPA3690 hypothetical protein YP_001178850.1 Involved in anaerobic NO protection YP_001178851.1 Confers resistance to chloramphenicol YP_001178852.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001178853.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_001178854.1 PFAM: protein of unknown function DUF37; KEGG: sdy:SDY_4187 hypothetical protein YP_001178855.1 TIGRFAM: ribonuclease P protein component; PFAM: ribonuclease P protein; KEGG: stm:STM3840 RNase P, protein component (protein C5), processes tRNA, 4.5S RNA YP_001178856.1 in Escherichia coli transcription of this gene is enhanced by polyamines