-- dump date 20140619_073212 -- class Genbank::misc_feature -- table misc_feature_note -- id note 716541000001 IncFII RepA protein family; Region: IncFII_repA; cl11495 716541000002 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 716541000003 VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal...; Region: VHS_ENTH_ANTH; cl02544 716541000004 TraX protein; Region: TraX; pfam05857 716541000005 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 716541000006 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 716541000007 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 716541000008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541000009 dimerization interface [polypeptide binding]; other site 716541000010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541000011 dimer interface [polypeptide binding]; other site 716541000012 phosphorylation site [posttranslational modification] 716541000013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541000014 ATP binding site [chemical binding]; other site 716541000015 Mg2+ binding site [ion binding]; other site 716541000016 G-X-G motif; other site 716541000017 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541000018 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541000019 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 716541000020 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 716541000021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541000022 active site 716541000023 phosphorylation site [posttranslational modification] 716541000024 intermolecular recognition site; other site 716541000025 dimerization interface [polypeptide binding]; other site 716541000026 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541000027 DNA binding site [nucleotide binding] 716541000028 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 716541000029 CopC domain; Region: CopC; pfam04234 716541000030 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 716541000031 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 716541000032 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 716541000033 The first cupredoxin domain of CopA copper resistance protein family; Region: CuRO_1_CopA; cd13848 716541000034 putative Domain 2 interface [polypeptide binding]; other site 716541000035 putative Domain 3 interface [polypeptide binding]; other site 716541000036 trinuclear Cu binding site [ion binding]; other site 716541000037 The second cupredoxin domain of CopA copper resistance protein family; Region: CuRO_2_CopA; cd13874 716541000038 putative Domain 1 interface [polypeptide binding]; other site 716541000039 putative Domain 3 interface [polypeptide binding]; other site 716541000040 The third cupredoxin domain of CopA copper resistance protein family; Region: CuRO_3_CopA; cd13896 716541000041 putative Domain 2 interface [polypeptide binding]; other site 716541000042 Type 1 (T1) Cu binding site [ion binding]; other site 716541000043 putative Domain 1 interface [polypeptide binding]; other site 716541000044 trinuclear Cu binding site [ion binding]; other site 716541000045 putative peptidase; Provisional; Region: PRK11649 716541000046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 716541000047 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690 716541000048 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 716541000049 Transposase; Region: DDE_Tnp_ISL3; pfam01610 716541000050 lipoprotein signal peptidase; Provisional; Region: PRK14776 716541000051 Heavy-metal-associated domain; Region: HMA; pfam00403 716541000052 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 716541000053 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 716541000054 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 716541000055 DNA binding residues [nucleotide binding] 716541000056 dimer interface [polypeptide binding]; other site 716541000057 putative metal binding site [ion binding]; other site 716541000058 Peptidase family M23; Region: Peptidase_M23; pfam01551 716541000059 SpoVR like protein; Region: SpoVR; cl19504 716541000060 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 716541000061 YHS domain; Region: YHS; pfam04945 716541000062 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 716541000063 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 716541000064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541000065 motif II; other site 716541000066 Protein of unknown function, DUF; Region: DUF411; cl01142 716541000067 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 716541000068 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 716541000069 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541000070 periplasmic copper-binding protein; Provisional; Region: PRK09838 716541000071 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 716541000072 Outer membrane efflux protein; Region: OEP; pfam02321 716541000073 Outer membrane efflux protein; Region: OEP; pfam02321 716541000074 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 716541000075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541000076 active site 716541000077 phosphorylation site [posttranslational modification] 716541000078 intermolecular recognition site; other site 716541000079 dimerization interface [polypeptide binding]; other site 716541000080 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541000081 DNA binding site [nucleotide binding] 716541000082 sensor kinase CusS; Provisional; Region: PRK09835 716541000083 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541000084 dimerization interface [polypeptide binding]; other site 716541000085 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541000086 dimer interface [polypeptide binding]; other site 716541000087 phosphorylation site [posttranslational modification] 716541000088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541000089 ATP binding site [chemical binding]; other site 716541000090 Mg2+ binding site [ion binding]; other site 716541000091 G-X-G motif; other site 716541000092 Domain of unknown function (DUF305); Region: DUF305; cl17794 716541000093 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 716541000094 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 716541000095 active site 716541000096 putative transcriptional regulator MerR; Provisional; Region: PRK13752 716541000097 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 716541000098 DNA binding residues [nucleotide binding] 716541000099 dimer interface [polypeptide binding]; other site 716541000100 mercury binding site [ion binding]; other site 716541000101 putative mercuric transport protein; Provisional; Region: PRK13751 716541000102 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 716541000103 metal-binding site [ion binding] 716541000104 putative mercury transport protein MerC; Provisional; Region: PRK13755 716541000105 putative mercuric reductase; Provisional; Region: PRK13748 716541000106 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 716541000107 metal-binding site [ion binding] 716541000108 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716541000109 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 716541000110 transcriptional regulator MerD; Provisional; Region: PRK13749 716541000111 Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111 716541000112 DNA binding residues [nucleotide binding] 716541000113 putative dimer interface [polypeptide binding]; other site 716541000114 putative mercury resistance protein; Provisional; Region: PRK13747 716541000115 HTH-like domain; Region: HTH_21; pfam13276 716541000116 Integrase core domain; Region: rve; pfam00665 716541000117 DDE domain; Region: DDE_Tnp_IS240; pfam13610 716541000118 Integrase core domain; Region: rve_3; pfam13683 716541000119 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541000120 Transposase; Region: HTH_Tnp_1; cl17663 716541000121 Phage terminase small subunit; Region: Phage_terminase; pfam10668 716541000122 Phage integrase family; Region: Phage_integrase; pfam00589 716541000123 active site 716541000124 DNA binding site [nucleotide binding] 716541000125 Int/Topo IB signature motif; other site 716541000126 Initiator Replication protein; Region: Rep_3; pfam01051 716541000127 plasmid-partitioning protein SopA; Provisional; Region: PRK13705 716541000128 DNA binding residues [nucleotide binding] 716541000129 MerR family regulatory protein; Region: MerR; pfam00376 716541000130 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 716541000131 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 716541000132 P-loop; other site 716541000133 Magnesium ion binding site [ion binding]; other site 716541000134 plasmid-partitioning protein; Provisional; Region: PRK13698 716541000135 ParB-like nuclease domain; Region: ParB; smart00470 716541000136 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 716541000137 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 716541000138 active site 716541000139 DNA binding site [nucleotide binding] 716541000140 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 716541000141 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 716541000142 Catalytic site [active] 716541000143 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 716541000144 Mg binding site [ion binding]; other site 716541000145 nucleotide binding site [chemical binding]; other site 716541000146 putative protofilament interface [polypeptide binding]; other site 716541000147 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 716541000148 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 716541000149 putative methylase; Provisional; Region: PRK13699 716541000150 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 716541000151 Antirestriction protein; Region: Antirestrict; pfam03230 716541000152 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 716541000153 zinc metallopeptidase RseP; Provisional; Region: PRK10779 716541000154 ParB-like nuclease domain; Region: ParBc; cl02129 716541000155 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 716541000156 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 716541000157 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 716541000158 PsiA protein; Region: PsiA; pfam06952 716541000159 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541000160 Helix-turn-helix domain; Region: HTH_28; pfam13518 716541000161 Helix-turn-helix domain; Region: HTH_28; pfam13518 716541000162 putative transposase OrfB; Reviewed; Region: PHA02517 716541000163 HTH-like domain; Region: HTH_21; pfam13276 716541000164 Integrase core domain; Region: rve; pfam00665 716541000165 Integrase core domain; Region: rve_2; pfam13333 716541000166 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716541000167 dimerization interface [polypeptide binding]; other site 716541000168 putative DNA binding site [nucleotide binding]; other site 716541000169 putative Zn2+ binding site [ion binding]; other site 716541000170 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 716541000171 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 716541000172 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 716541000173 P loop; other site 716541000174 Nucleotide binding site [chemical binding]; other site 716541000175 DTAP/Switch II; other site 716541000176 Switch I; other site 716541000177 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 716541000178 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 716541000179 P loop; other site 716541000180 Nucleotide binding site [chemical binding]; other site 716541000181 DTAP/Switch II; other site 716541000182 Switch I; other site 716541000183 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 716541000184 Citrate transporter; Region: CitMHS; pfam03600 716541000185 transmembrane helices; other site 716541000186 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 716541000187 catalytic residues [active] 716541000188 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 716541000189 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541000190 Coenzyme A binding pocket [chemical binding]; other site 716541000191 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 716541000192 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 716541000193 P loop; other site 716541000194 Nucleotide binding site [chemical binding]; other site 716541000195 DTAP/Switch II; other site 716541000196 Switch I; other site 716541000197 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 716541000198 P loop; other site 716541000199 Nucleotide binding site [chemical binding]; other site 716541000200 DTAP/Switch II; other site 716541000201 Switch I; other site 716541000202 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 716541000203 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 716541000204 RNA polymerase sigma factor, SigZ family; Region: SigZ; TIGR02959 716541000205 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 716541000206 DNA binding residues [nucleotide binding] 716541000207 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 716541000208 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716541000209 dimerization interface [polypeptide binding]; other site 716541000210 putative DNA binding site [nucleotide binding]; other site 716541000211 putative Zn2+ binding site [ion binding]; other site 716541000212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 716541000213 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 716541000214 Helix-turn-helix domain; Region: HTH_28; pfam13518 716541000215 Winged helix-turn helix; Region: HTH_29; pfam13551 716541000216 Homeodomain-like domain; Region: HTH_32; pfam13565 716541000217 Integrase core domain; Region: rve; pfam00665 716541000218 Integrase core domain; Region: rve_3; cl15866 716541000219 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 716541000220 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 716541000221 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 716541000222 putative homodimer interface [polypeptide binding]; other site 716541000223 putative homotetramer interface [polypeptide binding]; other site 716541000224 putative metal binding site [ion binding]; other site 716541000225 putative homodimer-homodimer interface [polypeptide binding]; other site 716541000226 putative allosteric switch controlling residues; other site 716541000227 H+ Antiporter protein; Region: 2A0121; TIGR00900 716541000228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541000229 putative substrate translocation pore; other site 716541000230 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 716541000231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 716541000232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716541000233 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 716541000234 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 716541000235 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 716541000236 Chromate transporter; Region: Chromate_transp; pfam02417 716541000237 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 716541000238 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 716541000239 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 716541000240 HTH-like domain; Region: HTH_21; pfam13276 716541000241 Integrase core domain; Region: rve; pfam00665 716541000242 Integrase core domain; Region: rve_3; pfam13683 716541000243 Transposase; Region: HTH_Tnp_1; pfam01527 716541000244 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 716541000245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 716541000246 Integrase core domain; Region: rve; pfam00665 716541000247 Integrase core domain; Region: rve_3; pfam13683 716541000248 putative transposase OrfB; Reviewed; Region: PHA02517 716541000249 HTH-like domain; Region: HTH_21; pfam13276 716541000250 Integrase core domain; Region: rve; pfam00665 716541000251 Integrase core domain; Region: rve_3; pfam13683 716541000252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541000253 Transposase; Region: HTH_Tnp_1; cl17663 716541000254 Helix-turn-helix domain; Region: HTH_28; pfam13518 716541000255 small toxic polypeptide; Provisional; Region: PRK09738 716541000256 Protein of unknown function (DUF1419); Region: DUF1419; pfam07215 716541000257 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 716541000258 Domain of unknown function (DUF932); Region: DUF932; pfam06067 716541000259 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 716541000260 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716541000261 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716541000262 catalytic residue [active] 716541000263 TraM protein, DNA-binding; Region: Tra_M; cl11621 716541000264 TraA; Region: TraA; cl11503 716541000265 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 716541000266 TraE protein; Region: TraE; cl05060 716541000267 conjugal transfer protein TraK; Provisional; Region: PRK13736 716541000268 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 716541000269 HemX; Region: HemX; cl19375 716541000270 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 716541000271 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 716541000272 conjugal transfer protein TraV; Provisional; Region: PRK13733 716541000273 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 716541000274 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 716541000275 Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; pfam09677 716541000276 conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738 716541000277 conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737 716541000278 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 716541000279 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 716541000280 Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; cl19475 716541000281 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 716541000282 conjugal transfer protein TrbB; Provisional; Region: PRK13728 716541000283 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 716541000284 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 716541000285 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 716541000286 Enterobacterial TraT complement resistance protein; Region: TraT; cl19728 716541000287 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 716541000288 F sex factor protein N terminal; Region: TraD_N; pfam12615 716541000289 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 716541000290 Walker A motif; other site 716541000291 ATP binding site [chemical binding]; other site 716541000292 Walker B motif; other site 716541000293 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 716541000294 TrwC relaxase; Region: TrwC; cl19905 716541000295 AAA domain; Region: AAA_30; pfam13604 716541000296 DNA helicase TraI; Region: TraI; pfam07057 716541000297 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 716541000298 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 716541000299 catalytic residues [active] 716541000300 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; cl08066 716541000301 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 716541000302 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 716541000303 active site 716541000304 DNA binding site [nucleotide binding] 716541000305 Int/Topo IB signature motif; other site 716541000306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541000307 Transposase; Region: HTH_Tnp_1; cl17663 716541000308 HTH-like domain; Region: HTH_21; pfam13276 716541000309 Integrase core domain; Region: rve; pfam00665 716541000310 DDE domain; Region: DDE_Tnp_IS240; pfam13610 716541000311 Integrase core domain; Region: rve_3; pfam13683 716541000312 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 716541000313 substrate binding site [chemical binding]; other site 716541000314 activation loop (A-loop); other site 716541000315 Protein phosphatase 2C; Region: PP2C_2; pfam13672 716541000316 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 716541000317 metal ion-dependent adhesion site (MIDAS); other site 716541000318 TerY-C metal binding domain; Region: TerY-C; pfam15616 716541000319 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 716541000320 metal ion-dependent adhesion site (MIDAS); other site 716541000321 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 716541000322 putative metal binding site [ion binding]; other site 716541000323 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 716541000324 metal ion-dependent adhesion site (MIDAS); other site 716541000325 Predicted transcriptional regulator [Transcription]; Region: COG2378 716541000326 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 716541000327 C-C_Bond_Lyase of the TIM-Barrel fold; Region: C-C_Bond_Lyase; pfam15617 716541000328 Phosphoribosyl transferase (PRTase); Region: PRTase_1; pfam11202 716541000329 PELOTA RNA binding domain; Region: PELOTA_1; pfam15608 716541000330 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 716541000331 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 716541000332 active site 716541000333 TRSP domain C terminus to PRTase_2; Region: TRSP; pfam12500 716541000334 ATP-grasp in the biosynthetic pathway with Ter operon; Region: ATPgrasp_Ter; pfam15632 716541000335 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 716541000336 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 716541000337 putative metal binding site [ion binding]; other site 716541000338 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 716541000339 putative metal binding site [ion binding]; other site 716541000340 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 716541000341 putative metal binding site [ion binding]; other site 716541000342 tellurite resistance protein terB; Region: terB; cd07176 716541000343 putative metal binding site [ion binding]; other site 716541000344 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 716541000345 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 716541000346 putative metal binding site [ion binding]; other site 716541000347 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 716541000348 putative metal binding site [ion binding]; other site 716541000349 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 716541000350 putative metal binding site [ion binding]; other site 716541000351 vWA found in TerF C terminus; Region: vWA-TerF-like; pfam10138 716541000352 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 716541000353 Transposase; Region: DEDD_Tnp_IS110; pfam01548 716541000354 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 716541000355 multiple promoter invertase; Provisional; Region: mpi; PRK13413 716541000356 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 716541000357 catalytic residues [active] 716541000358 catalytic nucleophile [active] 716541000359 Presynaptic Site I dimer interface [polypeptide binding]; other site 716541000360 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 716541000361 Synaptic Flat tetramer interface [polypeptide binding]; other site 716541000362 Synaptic Site I dimer interface [polypeptide binding]; other site 716541000363 DNA binding site [nucleotide binding] 716541000364 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 716541000365 DNA-binding interface [nucleotide binding]; DNA binding site 716541000366 Bacterial TniB protein; Region: TniB; pfam05621 716541000367 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 716541000368 TniQ; Region: TniQ; pfam06527 716541000369 multiple promoter invertase; Provisional; Region: mpi; PRK13413 716541000370 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 716541000371 catalytic residues [active] 716541000372 catalytic nucleophile [active] 716541000373 Presynaptic Site I dimer interface [polypeptide binding]; other site 716541000374 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 716541000375 Synaptic Flat tetramer interface [polypeptide binding]; other site 716541000376 Synaptic Site I dimer interface [polypeptide binding]; other site 716541000377 DNA binding site [nucleotide binding] 716541000378 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 716541000379 DNA-binding interface [nucleotide binding]; DNA binding site 716541000380 putative mercury resistance protein; Provisional; Region: PRK13747 716541000381 transcriptional regulator MerD; Provisional; Region: PRK13749 716541000382 Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111 716541000383 DNA binding residues [nucleotide binding] 716541000384 putative dimer interface [polypeptide binding]; other site 716541000385 putative mercuric reductase; Provisional; Region: PRK13748 716541000386 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 716541000387 metal-binding site [ion binding] 716541000388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716541000389 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 716541000390 Membrane transport protein MerF; Region: Transport_MerF; pfam11431 716541000391 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 716541000392 metal-binding site [ion binding] 716541000393 putative mercuric transport protein; Provisional; Region: PRK13751 716541000394 putative transcriptional regulator MerR; Provisional; Region: PRK13752 716541000395 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 716541000396 DNA binding residues [nucleotide binding] 716541000397 dimer interface [polypeptide binding]; other site 716541000398 mercury binding site [ion binding]; other site 716541000399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 716541000400 Transposase; Region: DEDD_Tnp_IS110; pfam01548 716541000401 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 716541000402 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 716541000403 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 716541000404 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 716541000405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 716541000406 Transposase; Region: HTH_Tnp_1; cl17663 716541000407 Integrase core domain; Region: rve; pfam00665 716541000408 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 716541000409 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 716541000410 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 716541000411 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 716541000412 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 716541000413 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 716541000414 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 716541000415 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 716541000416 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541000417 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 716541000418 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 716541000419 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 716541000420 ABC-2 type transporter; Region: ABC2_membrane; cl17235 716541000421 Transposase IS200 like; Region: Y1_Tnp; pfam01797 716541000422 Integrase core domain; Region: rve; pfam00665 716541000423 Integrase core domain; Region: rve_3; pfam13683 716541000424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 716541000425 Transposase; Region: DEDD_Tnp_IS110; pfam01548 716541000426 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 716541000427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 716541000428 Transposase; Region: HTH_Tnp_1; cl17663 716541000429 Integrase core domain; Region: rve; pfam00665 716541000430 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 716541000431 Ferritin-like domain; Region: Ferritin; pfam00210 716541000432 dinuclear metal binding motif [ion binding]; other site 716541000433 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 716541000434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 716541000435 Transposase; Region: HTH_Tnp_1; cl17663 716541000436 Integrase core domain; Region: rve; pfam00665 716541000437 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 716541000438 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 716541000439 Transposase; Region: HTH_Tnp_1; cl17663 716541000440 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541000441 HTH-like domain; Region: HTH_21; pfam13276 716541000442 Integrase core domain; Region: rve; pfam00665 716541000443 Integrase core domain; Region: rve_3; pfam13683 716541000444 ImpA domain protein; Region: DUF3702; pfam12486 716541000445 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541000446 Transposase; Region: HTH_Tnp_1; pfam01527 716541000447 putative transposase OrfB; Reviewed; Region: PHA02517 716541000448 HTH-like domain; Region: HTH_21; pfam13276 716541000449 Integrase core domain; Region: rve; pfam00665 716541000450 Integrase core domain; Region: rve_2; pfam13333 716541000451 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 716541000452 Abortive infection C-terminus; Region: Abi_C; pfam14355 716541000453 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 716541000454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 716541000455 Methyltransferase domain; Region: Methyltransf_27; pfam13708 716541000456 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 716541000457 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 716541000458 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 716541000459 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 716541000460 Cytochrome c; Region: Cytochrom_C; pfam00034 716541000461 Antirestriction protein; Region: Antirestrict; pfam03230 716541000462 Protein of unknown function (DUF1419); Region: DUF1419; pfam07215 716541000463 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 716541000464 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 716541000465 MPN+ (JAMM) motif; other site 716541000466 Zinc-binding site [ion binding]; other site 716541000467 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 716541000468 DNA-sulfur modification-associated; Region: DndB; pfam14072 716541000469 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 716541000470 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 716541000471 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541000472 non-specific DNA binding site [nucleotide binding]; other site 716541000473 salt bridge; other site 716541000474 sequence-specific DNA binding site [nucleotide binding]; other site 716541000475 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 716541000476 KorB domain; Region: KorB; pfam08535 716541000477 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 716541000478 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 716541000479 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 716541000480 P-loop; other site 716541000481 Magnesium ion binding site [ion binding]; other site 716541000482 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 716541000483 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 716541000484 dimerization domain [polypeptide binding]; other site 716541000485 dimer interface [polypeptide binding]; other site 716541000486 catalytic residues [active] 716541000487 TraL protein; Region: TraL; cl06278 716541000488 TraE protein; Region: TraE; cl05060 716541000489 TraK protein; Region: TraK; cl05878 716541000490 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 716541000491 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; cl19474 716541000492 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 716541000493 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 716541000494 Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; cl19475 716541000495 Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; cl19475 716541000496 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 716541000497 TraU protein; Region: TraU; pfam06834 716541000498 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 716541000499 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 716541000500 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 716541000501 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 716541000502 catalytic residues [active] 716541000503 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 716541000504 catalytic residues [active] 716541000505 Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580 716541000506 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 716541000507 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 716541000508 Haemolysin expression modulating protein; Region: HHA; cl11501 716541000509 replicative DNA helicase; Provisional; Region: PRK08006 716541000510 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 716541000511 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 716541000512 Walker A motif; other site 716541000513 ATP binding site [chemical binding]; other site 716541000514 Walker B motif; other site 716541000515 DNA binding loops [nucleotide binding] 716541000516 RES domain; Region: RES; pfam08808 716541000517 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 716541000518 active site 716541000519 catalytic residues [active] 716541000520 DNA binding site [nucleotide binding] 716541000521 Int/Topo IB signature motif; other site 716541000522 Staphylococcal nuclease homologues; Region: SNc; smart00318 716541000523 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 716541000524 Catalytic site; other site 716541000525 RelB antitoxin; Region: RelB; cl01171 716541000526 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 716541000527 Catalytic site [active] 716541000528 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 716541000529 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 716541000530 active site 716541000531 DNA binding site [nucleotide binding] 716541000532 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 716541000533 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 716541000534 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716541000535 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716541000536 catalytic residue [active] 716541000537 Restriction endonuclease; Region: Mrr_cat; pfam04471 716541000538 TraP protein; Region: TraP; cl11652 716541000539 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 716541000540 conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760 716541000541 TrwC relaxase; Region: TrwC; pfam08751 716541000542 AAA domain; Region: AAA_30; pfam13604 716541000543 AAA domain; Region: AAA_30; pfam13604 716541000544 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 716541000545 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 716541000546 Walker A motif; other site 716541000547 ATP binding site [chemical binding]; other site 716541000548 Walker B motif; other site 716541000549 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 716541000550 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 716541000551 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 716541000552 DnaA N-terminal domain; Region: DnaA_N; pfam11638 716541000553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541000554 Walker A motif; other site 716541000555 ATP binding site [chemical binding]; other site 716541000556 Walker B motif; other site 716541000557 arginine finger; other site 716541000558 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 716541000559 DnaA box-binding interface [nucleotide binding]; other site 716541000560 DNA polymerase III subunit beta; Validated; Region: PRK05643 716541000561 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 716541000562 putative DNA binding surface [nucleotide binding]; other site 716541000563 dimer interface [polypeptide binding]; other site 716541000564 beta-clamp/clamp loader binding surface; other site 716541000565 beta-clamp/translesion DNA polymerase binding surface; other site 716541000566 recF protein; Region: recf; TIGR00611 716541000567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541000568 Walker A/P-loop; other site 716541000569 ATP binding site [chemical binding]; other site 716541000570 Q-loop/lid; other site 716541000571 ABC transporter signature motif; other site 716541000572 Walker B; other site 716541000573 D-loop; other site 716541000574 H-loop/switch region; other site 716541000575 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 716541000576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541000577 ATP binding site [chemical binding]; other site 716541000578 Mg2+ binding site [ion binding]; other site 716541000579 G-X-G motif; other site 716541000580 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 716541000581 anchoring element; other site 716541000582 dimer interface [polypeptide binding]; other site 716541000583 ATP binding site [chemical binding]; other site 716541000584 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 716541000585 active site 716541000586 putative metal-binding site [ion binding]; other site 716541000587 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 716541000588 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541000589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541000590 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 716541000591 putative effector binding pocket; other site 716541000592 putative dimerization interface [polypeptide binding]; other site 716541000593 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 716541000594 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 716541000595 putative NAD(P) binding site [chemical binding]; other site 716541000596 sugar phosphate phosphatase; Provisional; Region: PRK10513 716541000597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541000598 active site 716541000599 motif I; other site 716541000600 motif II; other site 716541000601 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 716541000602 Transcriptional regulators [Transcription]; Region: FadR; COG2186 716541000603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541000604 DNA-binding site [nucleotide binding]; DNA binding site 716541000605 FCD domain; Region: FCD; pfam07729 716541000606 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 716541000607 Entner-Doudoroff aldolase; Region: eda; TIGR01182 716541000608 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 716541000609 active site 716541000610 intersubunit interface [polypeptide binding]; other site 716541000611 catalytic residue [active] 716541000612 galactonate dehydratase; Provisional; Region: PRK14017 716541000613 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 716541000614 putative active site pocket [active] 716541000615 putative metal binding site [ion binding]; other site 716541000616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541000617 D-galactonate transporter; Region: 2A0114; TIGR00893 716541000618 putative substrate translocation pore; other site 716541000619 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 716541000620 hypothetical protein; Provisional; Region: PRK11616 716541000621 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 716541000622 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 716541000623 putative dimer interface [polypeptide binding]; other site 716541000624 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 716541000625 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 716541000626 putative dimer interface [polypeptide binding]; other site 716541000627 putative transporter; Validated; Region: PRK03818 716541000628 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 716541000629 TrkA-C domain; Region: TrkA_C; pfam02080 716541000630 TrkA-C domain; Region: TrkA_C; pfam02080 716541000631 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 716541000632 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 716541000633 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541000634 DNA-binding site [nucleotide binding]; DNA binding site 716541000635 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 716541000636 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 716541000637 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 716541000638 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 716541000639 active site turn [active] 716541000640 phosphorylation site [posttranslational modification] 716541000641 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 716541000642 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 716541000643 NAD binding site [chemical binding]; other site 716541000644 sugar binding site [chemical binding]; other site 716541000645 divalent metal binding site [ion binding]; other site 716541000646 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 716541000647 dimer interface [polypeptide binding]; other site 716541000648 Domain of unknown function (DUF202); Region: DUF202; cl09954 716541000649 Domain of unknown function (DUF202); Region: DUF202; pfam02656 716541000650 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 716541000651 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 716541000652 catalytic residue [active] 716541000653 fructuronate transporter; Provisional; Region: PRK10034; cl15264 716541000654 fructuronate transporter; Provisional; Region: PRK10034; cl15264 716541000655 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 716541000656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541000657 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 716541000658 dimerization interface [polypeptide binding]; other site 716541000659 substrate binding pocket [chemical binding]; other site 716541000660 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 716541000661 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 716541000662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541000663 putative substrate translocation pore; other site 716541000664 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 716541000665 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 716541000666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541000667 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 716541000668 Coenzyme A binding pocket [chemical binding]; other site 716541000669 Protein of unknown function (DUF796); Region: DUF796; cl01226 716541000670 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 716541000671 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 716541000672 PYR/PP interface [polypeptide binding]; other site 716541000673 dimer interface [polypeptide binding]; other site 716541000674 TPP binding site [chemical binding]; other site 716541000675 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 716541000676 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 716541000677 TPP-binding site [chemical binding]; other site 716541000678 dimer interface [polypeptide binding]; other site 716541000679 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 716541000680 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 716541000681 putative valine binding site [chemical binding]; other site 716541000682 dimer interface [polypeptide binding]; other site 716541000683 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 716541000684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541000685 active site 716541000686 phosphorylation site [posttranslational modification] 716541000687 intermolecular recognition site; other site 716541000688 dimerization interface [polypeptide binding]; other site 716541000689 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541000690 DNA binding residues [nucleotide binding] 716541000691 dimerization interface [polypeptide binding]; other site 716541000692 sensory histidine kinase UhpB; Provisional; Region: PRK11644 716541000693 MASE1; Region: MASE1; pfam05231 716541000694 Histidine kinase; Region: HisKA_3; pfam07730 716541000695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541000696 ATP binding site [chemical binding]; other site 716541000697 Mg2+ binding site [ion binding]; other site 716541000698 G-X-G motif; other site 716541000699 regulatory protein UhpC; Provisional; Region: PRK11663 716541000700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541000701 putative substrate translocation pore; other site 716541000702 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 716541000703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541000704 putative substrate translocation pore; other site 716541000705 Putative lysophospholipase; Region: Hydrolase_4; cl19140 716541000706 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 716541000707 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541000708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541000709 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541000710 dimerization interface [polypeptide binding]; other site 716541000711 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 716541000712 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 716541000713 putative hydrophobic ligand binding site [chemical binding]; other site 716541000714 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 716541000715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541000716 putative substrate translocation pore; other site 716541000717 EamA-like transporter family; Region: EamA; pfam00892 716541000718 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 716541000719 EamA-like transporter family; Region: EamA; pfam00892 716541000720 maltoporin; Provisional; Region: lamB; PRK09360 716541000721 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 716541000722 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 716541000723 methionine cluster; other site 716541000724 active site 716541000725 phosphorylation site [posttranslational modification] 716541000726 metal binding site [ion binding]; metal-binding site 716541000727 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 716541000728 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 716541000729 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 716541000730 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 716541000731 active site 716541000732 P-loop; other site 716541000733 phosphorylation site [posttranslational modification] 716541000734 Transcriptional regulators [Transcription]; Region: PurR; COG1609 716541000735 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541000736 DNA binding site [nucleotide binding] 716541000737 domain linker motif; other site 716541000738 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 716541000739 ligand binding site [chemical binding]; other site 716541000740 dimerization interface [polypeptide binding]; other site 716541000741 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 716541000742 Outer membrane efflux protein; Region: OEP; pfam02321 716541000743 Outer membrane efflux protein; Region: OEP; pfam02321 716541000744 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 716541000745 MMPL family; Region: MMPL; cl14618 716541000746 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 716541000747 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541000748 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541000749 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 716541000750 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716541000751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541000752 Coenzyme A binding pocket [chemical binding]; other site 716541000753 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 716541000754 EAL domain; Region: EAL; pfam00563 716541000755 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 716541000756 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 716541000757 DNA binding residues [nucleotide binding] 716541000758 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 716541000759 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541000760 DNA binding residues [nucleotide binding] 716541000761 dimerization interface [polypeptide binding]; other site 716541000762 Fimbrial protein; Region: Fimbrial; cl01416 716541000763 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 716541000764 PapC N-terminal domain; Region: PapC_N; pfam13954 716541000765 Outer membrane usher protein; Region: Usher; pfam00577 716541000766 PapC C-terminal domain; Region: PapC_C; pfam13953 716541000767 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 716541000768 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 716541000769 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 716541000770 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 716541000771 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541000772 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541000773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 716541000774 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 716541000775 DNA binding site [nucleotide binding] 716541000776 putative fimbrial protein TcfA; Provisional; Region: PRK15308 716541000777 Outer membrane usher protein; Region: Usher; pfam00577 716541000778 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 716541000779 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 716541000780 putative active site [active] 716541000781 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 716541000782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541000783 Walker A/P-loop; other site 716541000784 ATP binding site [chemical binding]; other site 716541000785 Q-loop/lid; other site 716541000786 ABC transporter signature motif; other site 716541000787 Walker B; other site 716541000788 D-loop; other site 716541000789 H-loop/switch region; other site 716541000790 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 716541000791 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541000792 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541000793 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 716541000794 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 716541000795 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 716541000796 conserved cys residue [active] 716541000797 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541000798 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541000799 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 716541000800 active site 716541000801 zinc binding site [ion binding]; other site 716541000802 Predicted ATPase [General function prediction only]; Region: COG4637 716541000803 AAA domain; Region: AAA_23; pfam13476 716541000804 Walker A/P-loop; other site 716541000805 ATP binding site [chemical binding]; other site 716541000806 ABC transporter signature motif; other site 716541000807 AAA domain; Region: AAA_21; pfam13304 716541000808 Walker B; other site 716541000809 D-loop; other site 716541000810 H-loop/switch region; other site 716541000811 Protein of unknown function (DUF523); Region: DUF523; pfam04463 716541000812 Uncharacterized conserved protein [Function unknown]; Region: COG3272 716541000813 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 716541000814 active site 716541000815 homotetramer interface [polypeptide binding]; other site 716541000816 transcriptional regulator MirA; Provisional; Region: PRK15043 716541000817 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 716541000818 DNA binding residues [nucleotide binding] 716541000819 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 716541000820 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 716541000821 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 716541000822 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 716541000823 PapC N-terminal domain; Region: PapC_N; pfam13954 716541000824 Outer membrane usher protein; Region: Usher; pfam00577 716541000825 PapC C-terminal domain; Region: PapC_C; pfam13953 716541000826 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 716541000827 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 716541000828 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 716541000829 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 716541000830 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 716541000831 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 716541000832 DNA binding residues [nucleotide binding] 716541000833 dimerization interface [polypeptide binding]; other site 716541000834 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 716541000835 DNA binding site [nucleotide binding] 716541000836 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 716541000837 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 716541000838 conserved cys residue [active] 716541000839 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 716541000840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541000841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541000842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 716541000843 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 716541000844 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541000845 Coenzyme A binding pocket [chemical binding]; other site 716541000846 Virulence protein RhuM family; Region: Virulence_RhuM; cl19850 716541000847 Virulence protein RhuM family; Region: Virulence_RhuM; cl19850 716541000848 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 716541000849 putative alpha-glucosidase; Provisional; Region: PRK10658 716541000850 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 716541000851 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 716541000852 active site 716541000853 homotrimer interface [polypeptide binding]; other site 716541000854 catalytic site [active] 716541000855 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 716541000856 AsmA family; Region: AsmA; pfam05170 716541000857 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 716541000858 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 716541000859 Sulfate transporter family; Region: Sulfate_transp; cl19250 716541000860 Sodium/glutamate symporter; Region: Glt_symporter; cl19414 716541000861 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 716541000862 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 716541000863 generic binding surface II; other site 716541000864 ssDNA binding site; other site 716541000865 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716541000866 ATP binding site [chemical binding]; other site 716541000867 putative Mg++ binding site [ion binding]; other site 716541000868 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716541000869 nucleotide binding region [chemical binding]; other site 716541000870 ATP-binding site [chemical binding]; other site 716541000871 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 716541000872 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 716541000873 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 716541000874 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 716541000875 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 716541000876 Zn2+ binding site [ion binding]; other site 716541000877 Mg2+ binding site [ion binding]; other site 716541000878 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 716541000879 synthetase active site [active] 716541000880 NTP binding site [chemical binding]; other site 716541000881 metal binding site [ion binding]; metal-binding site 716541000882 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 716541000883 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 716541000884 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 716541000885 Guanylate kinase; Region: Guanylate_kin; pfam00625 716541000886 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 716541000887 catalytic site [active] 716541000888 G-X2-G-X-G-K; other site 716541000889 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 716541000890 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 716541000891 nucleotide binding pocket [chemical binding]; other site 716541000892 K-X-D-G motif; other site 716541000893 catalytic site [active] 716541000894 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 716541000895 Predicted membrane protein [Function unknown]; Region: COG2860 716541000896 UPF0126 domain; Region: UPF0126; pfam03458 716541000897 UPF0126 domain; Region: UPF0126; pfam03458 716541000898 hypothetical protein; Provisional; Region: PRK11820 716541000899 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 716541000900 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 716541000901 ribonuclease PH; Reviewed; Region: rph; PRK00173 716541000902 Ribonuclease PH; Region: RNase_PH_bact; cd11362 716541000903 hexamer interface [polypeptide binding]; other site 716541000904 active site 716541000905 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 716541000906 active site 716541000907 division inhibitor protein; Provisional; Region: slmA; PRK09480 716541000908 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716541000909 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 716541000910 trimer interface [polypeptide binding]; other site 716541000911 active site 716541000912 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 716541000913 Flavoprotein; Region: Flavoprotein; cl19190 716541000914 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 716541000915 hypothetical protein; Reviewed; Region: PRK00024 716541000916 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 716541000917 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 716541000918 MPN+ (JAMM) motif; other site 716541000919 Zinc-binding site [ion binding]; other site 716541000920 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 716541000921 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 716541000922 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 716541000923 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 716541000924 DNA binding site [nucleotide binding] 716541000925 catalytic residue [active] 716541000926 H2TH interface [polypeptide binding]; other site 716541000927 putative catalytic residues [active] 716541000928 turnover-facilitating residue; other site 716541000929 intercalation triad [nucleotide binding]; other site 716541000930 8OG recognition residue [nucleotide binding]; other site 716541000931 putative reading head residues; other site 716541000932 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 716541000933 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 716541000934 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 716541000935 active site 716541000936 (T/H)XGH motif; other site 716541000937 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 716541000938 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 716541000939 putative metal binding site; other site 716541000940 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 716541000941 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 716541000942 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 716541000943 putative glycosyl transferase; Provisional; Region: PRK10073 716541000944 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 716541000945 active site 716541000946 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 716541000947 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 716541000948 putative ADP-binding pocket [chemical binding]; other site 716541000949 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 716541000950 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 716541000951 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 716541000952 putative active site [active] 716541000953 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 716541000954 putative active site [active] 716541000955 putative catalytic site [active] 716541000956 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 716541000957 O-Antigen ligase; Region: Wzy_C; pfam04932 716541000958 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 716541000959 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 716541000960 active site 716541000961 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 716541000962 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 716541000963 putative active site [active] 716541000964 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 716541000965 putative active site [active] 716541000966 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 716541000967 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 716541000968 NADP binding site [chemical binding]; other site 716541000969 homopentamer interface [polypeptide binding]; other site 716541000970 substrate binding site [chemical binding]; other site 716541000971 active site 716541000972 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 716541000973 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 716541000974 substrate-cofactor binding pocket; other site 716541000975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541000976 catalytic residue [active] 716541000977 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 716541000978 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 716541000979 NAD(P) binding site [chemical binding]; other site 716541000980 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 716541000981 HTH-like domain; Region: HTH_21; pfam13276 716541000982 Integrase core domain; Region: rve; pfam00665 716541000983 Integrase core domain; Region: rve_3; pfam13683 716541000984 Transposase; Region: HTH_Tnp_1; cl17663 716541000985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541000986 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 716541000987 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 716541000988 putative ADP-binding pocket [chemical binding]; other site 716541000989 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 716541000990 NodB motif; other site 716541000991 putative active site [active] 716541000992 putative catalytic site [active] 716541000993 Zn binding site [ion binding]; other site 716541000994 AmiB activator; Provisional; Region: PRK11637 716541000995 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 716541000996 Peptidase family M23; Region: Peptidase_M23; pfam01551 716541000997 phosphoglyceromutase; Provisional; Region: PRK05434 716541000998 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 716541000999 active site residue [active] 716541001000 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 716541001001 GSH binding site [chemical binding]; other site 716541001002 catalytic residues [active] 716541001003 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 716541001004 SecA binding site; other site 716541001005 Preprotein binding site; other site 716541001006 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 716541001007 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 716541001008 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 716541001009 serine acetyltransferase; Provisional; Region: cysE; PRK11132 716541001010 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 716541001011 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 716541001012 trimer interface [polypeptide binding]; other site 716541001013 active site 716541001014 substrate binding site [chemical binding]; other site 716541001015 CoA binding site [chemical binding]; other site 716541001016 putative rRNA methylase; Provisional; Region: PRK10358 716541001017 benzoate transport; Region: 2A0115; TIGR00895 716541001018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541001019 putative substrate translocation pore; other site 716541001020 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 716541001021 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 716541001022 active site 716541001023 substrate binding site [chemical binding]; other site 716541001024 FMN binding site [chemical binding]; other site 716541001025 putative catalytic residues [active] 716541001026 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 716541001027 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541001028 DNA-binding site [nucleotide binding]; DNA binding site 716541001029 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 716541001030 L-lactate permease; Provisional; Region: PRK10420 716541001031 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 716541001032 AAA domain; Region: AAA_12; pfam13087 716541001033 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 716541001034 putative active site [active] 716541001035 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 716541001036 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 716541001037 HTH-like domain; Region: HTH_21; pfam13276 716541001038 Integrase core domain; Region: rve; pfam00665 716541001039 Integrase core domain; Region: rve_3; pfam13683 716541001040 Transposase; Region: HTH_Tnp_1; pfam01527 716541001041 hypothetical protein; Provisional; Region: PRK11020 716541001042 Protein of unknown function (DUF2810); Region: DUF2810; cl08159 716541001043 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 716541001044 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 716541001045 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 716541001046 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 716541001047 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 716541001048 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 716541001049 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 716541001050 active site 716541001051 P-loop; other site 716541001052 phosphorylation site [posttranslational modification] 716541001053 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 716541001054 active site 716541001055 phosphorylation site [posttranslational modification] 716541001056 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 716541001057 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 716541001058 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541001059 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541001060 putative glutathione S-transferase; Provisional; Region: PRK10357 716541001061 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 716541001062 putative C-terminal domain interface [polypeptide binding]; other site 716541001063 putative GSH binding site (G-site) [chemical binding]; other site 716541001064 putative dimer interface [polypeptide binding]; other site 716541001065 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 716541001066 dimer interface [polypeptide binding]; other site 716541001067 N-terminal domain interface [polypeptide binding]; other site 716541001068 putative substrate binding pocket (H-site) [chemical binding]; other site 716541001069 selenocysteine synthase; Provisional; Region: PRK04311 716541001070 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 716541001071 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 716541001072 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 716541001073 catalytic residue [active] 716541001074 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 716541001075 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 716541001076 G1 box; other site 716541001077 putative GEF interaction site [polypeptide binding]; other site 716541001078 GTP/Mg2+ binding site [chemical binding]; other site 716541001079 Switch I region; other site 716541001080 G2 box; other site 716541001081 G3 box; other site 716541001082 Switch II region; other site 716541001083 G4 box; other site 716541001084 G5 box; other site 716541001085 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 716541001086 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 716541001087 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 716541001088 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 716541001089 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 716541001090 NAD(P) binding site [chemical binding]; other site 716541001091 catalytic residues [active] 716541001092 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541001093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541001094 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541001095 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 716541001096 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 716541001097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 716541001098 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 716541001099 putative symporter YagG; Provisional; Region: PRK09669; cl15392 716541001100 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 716541001101 Helix-turn-helix domain; Region: HTH_18; pfam12833 716541001102 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541001103 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 716541001104 intersubunit interface [polypeptide binding]; other site 716541001105 active site 716541001106 Zn2+ binding site [ion binding]; other site 716541001107 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 716541001108 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 716541001109 AP (apurinic/apyrimidinic) site pocket; other site 716541001110 DNA interaction; other site 716541001111 Metal-binding active site; metal-binding site 716541001112 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 716541001113 active site 716541001114 dimer interface [polypeptide binding]; other site 716541001115 magnesium binding site [ion binding]; other site 716541001116 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 716541001117 putative N- and C-terminal domain interface [polypeptide binding]; other site 716541001118 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 716541001119 putative active site [active] 716541001120 MgATP binding site [chemical binding]; other site 716541001121 catalytic site [active] 716541001122 metal binding site [ion binding]; metal-binding site 716541001123 putative xylulose binding site [chemical binding]; other site 716541001124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541001125 D-galactonate transporter; Region: 2A0114; TIGR00893 716541001126 putative substrate translocation pore; other site 716541001127 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 716541001128 Metal-binding active site; metal-binding site 716541001129 Domain of unknown function (DUF386); Region: DUF386; pfam04074 716541001130 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 716541001131 Transcriptional regulator [Transcription]; Region: IclR; COG1414 716541001132 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 716541001133 Bacterial transcriptional regulator; Region: IclR; pfam01614 716541001134 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 716541001135 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 716541001136 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 716541001137 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716541001138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541001139 homodimer interface [polypeptide binding]; other site 716541001140 catalytic residue [active] 716541001141 alpha-amylase; Reviewed; Region: malS; PRK09505 716541001142 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 716541001143 active site 716541001144 catalytic site [active] 716541001145 hypothetical protein; Provisional; Region: PRK10356 716541001146 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 716541001147 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 716541001148 putative dimerization interface [polypeptide binding]; other site 716541001149 Transcriptional regulators [Transcription]; Region: PurR; COG1609 716541001150 putative ligand binding site [chemical binding]; other site 716541001151 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 716541001152 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541001153 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541001154 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 716541001155 TM-ABC transporter signature motif; other site 716541001156 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 716541001157 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 716541001158 Walker A/P-loop; other site 716541001159 ATP binding site [chemical binding]; other site 716541001160 Q-loop/lid; other site 716541001161 ABC transporter signature motif; other site 716541001162 Walker B; other site 716541001163 D-loop; other site 716541001164 H-loop/switch region; other site 716541001165 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 716541001166 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 716541001167 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 716541001168 putative ligand binding site [chemical binding]; other site 716541001169 xylose isomerase; Provisional; Region: PRK05474 716541001170 xylulokinase; Provisional; Region: PRK15027 716541001171 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 716541001172 N- and C-terminal domain interface [polypeptide binding]; other site 716541001173 active site 716541001174 MgATP binding site [chemical binding]; other site 716541001175 catalytic site [active] 716541001176 metal binding site [ion binding]; metal-binding site 716541001177 xylulose binding site [chemical binding]; other site 716541001178 homodimer interface [polypeptide binding]; other site 716541001179 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 716541001180 catalytic triad [active] 716541001181 conserved cis-peptide bond; other site 716541001182 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 716541001183 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 716541001184 conserved cys residue [active] 716541001185 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541001186 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 716541001187 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 716541001188 YsaB-like lipoprotein; Region: YsaB; pfam13983 716541001189 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 716541001190 dimer interface [polypeptide binding]; other site 716541001191 motif 1; other site 716541001192 active site 716541001193 motif 2; other site 716541001194 motif 3; other site 716541001195 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 716541001196 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 716541001197 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 716541001198 anticodon binding site; other site 716541001199 tRNA binding surface [nucleotide binding]; other site 716541001200 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 716541001201 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716541001202 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716541001203 Predicted transcriptional regulator [Transcription]; Region: COG2944 716541001204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541001205 salt bridge; other site 716541001206 non-specific DNA binding site [nucleotide binding]; other site 716541001207 sequence-specific DNA binding site [nucleotide binding]; other site 716541001208 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 716541001209 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 716541001210 DNA-binding site [nucleotide binding]; DNA binding site 716541001211 RNA-binding motif; other site 716541001212 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 716541001213 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 716541001214 dimerization interface [polypeptide binding]; other site 716541001215 ligand binding site [chemical binding]; other site 716541001216 NADP binding site [chemical binding]; other site 716541001217 catalytic site [active] 716541001218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541001219 D-galactonate transporter; Region: 2A0114; TIGR00893 716541001220 putative substrate translocation pore; other site 716541001221 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 716541001222 substrate binding site [chemical binding]; other site 716541001223 ATP binding site [chemical binding]; other site 716541001224 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 716541001225 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 716541001226 Transcriptional regulators [Transcription]; Region: PurR; COG1609 716541001227 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541001228 DNA binding site [nucleotide binding] 716541001229 domain linker motif; other site 716541001230 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 716541001231 putative dimerization interface [polypeptide binding]; other site 716541001232 putative ligand binding site [chemical binding]; other site 716541001233 putative outer membrane lipoprotein; Provisional; Region: PRK10510 716541001234 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 716541001235 ligand binding site [chemical binding]; other site 716541001236 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 716541001237 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 716541001238 molybdopterin cofactor binding site [chemical binding]; other site 716541001239 substrate binding site [chemical binding]; other site 716541001240 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 716541001241 molybdopterin cofactor binding site; other site 716541001242 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 716541001243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541001244 Coenzyme A binding pocket [chemical binding]; other site 716541001245 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 716541001246 Autotransporter beta-domain; Region: Autotransporter; cl17461 716541001247 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 716541001248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541001249 putative substrate translocation pore; other site 716541001250 phosphoethanolamine transferase; Provisional; Region: PRK11560 716541001251 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 716541001252 Sulfatase; Region: Sulfatase; pfam00884 716541001253 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 716541001254 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 716541001255 peptide binding site [polypeptide binding]; other site 716541001256 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 716541001257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541001258 dimer interface [polypeptide binding]; other site 716541001259 conserved gate region; other site 716541001260 putative PBP binding loops; other site 716541001261 ABC-ATPase subunit interface; other site 716541001262 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 716541001263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541001264 dimer interface [polypeptide binding]; other site 716541001265 conserved gate region; other site 716541001266 putative PBP binding loops; other site 716541001267 ABC-ATPase subunit interface; other site 716541001268 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 716541001269 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716541001270 Walker A/P-loop; other site 716541001271 ATP binding site [chemical binding]; other site 716541001272 Q-loop/lid; other site 716541001273 ABC transporter signature motif; other site 716541001274 Walker B; other site 716541001275 D-loop; other site 716541001276 H-loop/switch region; other site 716541001277 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 716541001278 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 716541001279 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716541001280 Walker A/P-loop; other site 716541001281 ATP binding site [chemical binding]; other site 716541001282 Q-loop/lid; other site 716541001283 ABC transporter signature motif; other site 716541001284 Walker B; other site 716541001285 D-loop; other site 716541001286 H-loop/switch region; other site 716541001287 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 716541001288 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 716541001289 ATP-binding site [chemical binding]; other site 716541001290 CoA-binding site [chemical binding]; other site 716541001291 Mg2+-binding site [ion binding]; other site 716541001292 elongation factor Tu; Reviewed; Region: PRK00049 716541001293 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 716541001294 G1 box; other site 716541001295 GEF interaction site [polypeptide binding]; other site 716541001296 GTP/Mg2+ binding site [chemical binding]; other site 716541001297 Switch I region; other site 716541001298 G2 box; other site 716541001299 G3 box; other site 716541001300 Switch II region; other site 716541001301 G4 box; other site 716541001302 G5 box; other site 716541001303 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 716541001304 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 716541001305 Antibiotic Binding Site [chemical binding]; other site 716541001306 Uncharacterized protein conserved in archaea (DUF2193); Region: DUF2193; cl02034 716541001307 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 716541001308 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 716541001309 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 716541001310 putative homodimer interface [polypeptide binding]; other site 716541001311 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 716541001312 heterodimer interface [polypeptide binding]; other site 716541001313 homodimer interface [polypeptide binding]; other site 716541001314 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 716541001315 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 716541001316 23S rRNA interface [nucleotide binding]; other site 716541001317 L7/L12 interface [polypeptide binding]; other site 716541001318 putative thiostrepton binding site; other site 716541001319 L25 interface [polypeptide binding]; other site 716541001320 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 716541001321 mRNA/rRNA interface [nucleotide binding]; other site 716541001322 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 716541001323 23S rRNA interface [nucleotide binding]; other site 716541001324 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 716541001325 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 716541001326 core dimer interface [polypeptide binding]; other site 716541001327 peripheral dimer interface [polypeptide binding]; other site 716541001328 L10 interface [polypeptide binding]; other site 716541001329 L11 interface [polypeptide binding]; other site 716541001330 putative EF-Tu interaction site [polypeptide binding]; other site 716541001331 putative EF-G interaction site [polypeptide binding]; other site 716541001332 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 716541001333 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 716541001334 RPB12 interaction site [polypeptide binding]; other site 716541001335 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 716541001336 RPB1 interaction site [polypeptide binding]; other site 716541001337 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 716541001338 RPB10 interaction site [polypeptide binding]; other site 716541001339 RPB11 interaction site [polypeptide binding]; other site 716541001340 RPB3 interaction site [polypeptide binding]; other site 716541001341 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 716541001342 beta and beta' interface [polypeptide binding]; other site 716541001343 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 716541001344 beta' and sigma factor interface [polypeptide binding]; other site 716541001345 Zn-binding [ion binding]; other site 716541001346 active site region [active] 716541001347 catalytic site [active] 716541001348 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 716541001349 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 716541001350 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 716541001351 G-loop; other site 716541001352 DNA binding site [nucleotide binding] 716541001353 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 716541001354 methionine cluster; other site 716541001355 active site 716541001356 phosphorylation site [posttranslational modification] 716541001357 metal binding site [ion binding]; metal-binding site 716541001358 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 716541001359 Cache domain; Region: Cache_1; pfam02743 716541001360 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541001361 metal binding site [ion binding]; metal-binding site 716541001362 active site 716541001363 I-site; other site 716541001364 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 716541001365 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716541001366 FeS/SAM binding site; other site 716541001367 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 716541001368 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 716541001369 ThiS interaction site; other site 716541001370 putative active site [active] 716541001371 tetramer interface [polypeptide binding]; other site 716541001372 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 716541001373 thiS-thiF/thiG interaction site; other site 716541001374 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 716541001375 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 716541001376 ATP binding site [chemical binding]; other site 716541001377 substrate interface [chemical binding]; other site 716541001378 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 716541001379 thiamine phosphate binding site [chemical binding]; other site 716541001380 active site 716541001381 pyrophosphate binding site [ion binding]; other site 716541001382 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 716541001383 ThiC-associated domain; Region: ThiC-associated; pfam13667 716541001384 ThiC family; Region: ThiC; pfam01964 716541001385 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 716541001386 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 716541001387 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 716541001388 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 716541001389 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 716541001390 putative NADH binding site [chemical binding]; other site 716541001391 putative active site [active] 716541001392 nudix motif; other site 716541001393 putative metal binding site [ion binding]; other site 716541001394 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 716541001395 substrate binding site [chemical binding]; other site 716541001396 active site 716541001397 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 716541001398 Active_site [active] 716541001399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 716541001400 histone-like DNA-binding protein HU; Region: HU; cd13831 716541001401 dimer interface [polypeptide binding]; other site 716541001402 DNA binding site [nucleotide binding] 716541001403 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 716541001404 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 716541001405 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 716541001406 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 716541001407 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 716541001408 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 716541001409 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 716541001410 purine monophosphate binding site [chemical binding]; other site 716541001411 dimer interface [polypeptide binding]; other site 716541001412 putative catalytic residues [active] 716541001413 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 716541001414 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 716541001415 proposed active site lysine [active] 716541001416 conserved cys residue [active] 716541001417 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 716541001418 active site 716541001419 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 716541001420 tetramer interface [polypeptide binding]; other site 716541001421 active site 716541001422 Mg2+/Mn2+ binding site [ion binding]; other site 716541001423 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 716541001424 transcriptional repressor IclR; Provisional; Region: PRK11569 716541001425 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 716541001426 Bacterial transcriptional regulator; Region: IclR; pfam01614 716541001427 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 716541001428 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 716541001429 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 716541001430 substrate binding pocket [chemical binding]; other site 716541001431 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 716541001432 B12 binding site [chemical binding]; other site 716541001433 cobalt ligand [ion binding]; other site 716541001434 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 716541001435 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 716541001436 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 716541001437 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 716541001438 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 716541001439 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 716541001440 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 716541001441 RNA binding surface [nucleotide binding]; other site 716541001442 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 716541001443 probable active site [active] 716541001444 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 716541001445 aspartate kinase III; Validated; Region: PRK09084 716541001446 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 716541001447 nucleotide binding site [chemical binding]; other site 716541001448 putative catalytic residues [active] 716541001449 aspartate binding site [chemical binding]; other site 716541001450 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 716541001451 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 716541001452 dimer interface [polypeptide binding]; other site 716541001453 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 716541001454 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 716541001455 active site 716541001456 dimer interface [polypeptide binding]; other site 716541001457 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 716541001458 dimer interface [polypeptide binding]; other site 716541001459 active site 716541001460 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 716541001461 Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102 716541001462 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 716541001463 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 716541001464 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 716541001465 putative trimer interface [polypeptide binding]; other site 716541001466 putative active site [active] 716541001467 putative substrate binding site [chemical binding]; other site 716541001468 putative CoA binding site [chemical binding]; other site 716541001469 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 716541001470 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 716541001471 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 716541001472 active site 716541001473 P-loop; other site 716541001474 phosphorylation site [posttranslational modification] 716541001475 putative oxidoreductase; Provisional; Region: PRK10206 716541001476 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 716541001477 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 716541001478 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 716541001479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541001480 DNA-binding site [nucleotide binding]; DNA binding site 716541001481 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 716541001482 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 716541001483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541001484 dimer interface [polypeptide binding]; other site 716541001485 conserved gate region; other site 716541001486 putative PBP binding loops; other site 716541001487 ABC-ATPase subunit interface; other site 716541001488 maltose transporter membrane protein; Provisional; Region: malF; PRK10999 716541001489 Maltose transport system permease protein MalF P2 domain; Region: MalF_P2; pfam14785 716541001490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541001491 dimer interface [polypeptide binding]; other site 716541001492 conserved gate region; other site 716541001493 putative PBP binding loops; other site 716541001494 ABC-ATPase subunit interface; other site 716541001495 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 716541001496 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 716541001497 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 716541001498 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 716541001499 Walker A/P-loop; other site 716541001500 ATP binding site [chemical binding]; other site 716541001501 Q-loop/lid; other site 716541001502 ABC transporter signature motif; other site 716541001503 Walker B; other site 716541001504 D-loop; other site 716541001505 H-loop/switch region; other site 716541001506 TOBE domain; Region: TOBE_2; pfam08402 716541001507 maltoporin; Provisional; Region: lamB; PRK09360 716541001508 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 716541001509 trimer interface; other site 716541001510 sugar binding site [chemical binding]; other site 716541001511 maltose regulon periplasmic protein; Provisional; Region: PRK10564 716541001512 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 716541001513 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 716541001514 putative active site [active] 716541001515 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 716541001516 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 716541001517 putative acyl-acceptor binding pocket; other site 716541001518 Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264 716541001519 putative active site [active] 716541001520 trimer interface [polypeptide binding]; other site 716541001521 putative active site [active] 716541001522 Zn binding site [ion binding]; other site 716541001523 LexA repressor; Validated; Region: PRK00215 716541001524 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 716541001525 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 716541001526 Catalytic site [active] 716541001527 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 716541001528 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 716541001529 hypothetical protein; Provisional; Region: PRK10428 716541001530 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 716541001531 metal binding site 2 [ion binding]; metal-binding site 716541001532 putative DNA binding helix; other site 716541001533 metal binding site 1 [ion binding]; metal-binding site 716541001534 dimer interface [polypeptide binding]; other site 716541001535 structural Zn2+ binding site [ion binding]; other site 716541001536 Cupin domain; Region: Cupin_2; cl17218 716541001537 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 716541001538 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 716541001539 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 716541001540 FMN binding site [chemical binding]; other site 716541001541 active site 716541001542 catalytic residues [active] 716541001543 substrate binding site [chemical binding]; other site 716541001544 phage shock protein G; Reviewed; Region: pspG; PRK09459 716541001545 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 716541001546 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 716541001547 NADP binding site [chemical binding]; other site 716541001548 dimer interface [polypeptide binding]; other site 716541001549 replicative DNA helicase; Provisional; Region: PRK08006 716541001550 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 716541001551 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 716541001552 Walker A motif; other site 716541001553 ATP binding site [chemical binding]; other site 716541001554 Walker B motif; other site 716541001555 DNA binding loops [nucleotide binding] 716541001556 alanine racemase; Reviewed; Region: alr; PRK00053 716541001557 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 716541001558 active site 716541001559 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 716541001560 substrate binding site [chemical binding]; other site 716541001561 catalytic residues [active] 716541001562 dimer interface [polypeptide binding]; other site 716541001563 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 716541001564 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716541001565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541001566 homodimer interface [polypeptide binding]; other site 716541001567 catalytic residue [active] 716541001568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541001569 active site 716541001570 motif I; other site 716541001571 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 716541001572 motif II; other site 716541001573 Uncharacterized conserved protein [Function unknown]; Region: COG0432 716541001574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 716541001575 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 716541001576 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 716541001577 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 716541001578 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 716541001579 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 716541001580 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 716541001581 dimer interface [polypeptide binding]; other site 716541001582 ssDNA binding site [nucleotide binding]; other site 716541001583 tetramer (dimer of dimers) interface [polypeptide binding]; other site 716541001584 putative single-stranded DNA-binding protein; Region: PHA01740 716541001585 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 716541001586 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 716541001587 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541001588 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 716541001589 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541001590 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 716541001591 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 716541001592 DNA binding residues [nucleotide binding] 716541001593 dimer interface [polypeptide binding]; other site 716541001594 [2Fe-2S] cluster binding site [ion binding]; other site 716541001595 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 716541001596 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 716541001597 putative C-terminal domain interface [polypeptide binding]; other site 716541001598 putative GSH binding site (G-site) [chemical binding]; other site 716541001599 putative dimer interface [polypeptide binding]; other site 716541001600 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 716541001601 putative N-terminal domain interface [polypeptide binding]; other site 716541001602 putative dimer interface [polypeptide binding]; other site 716541001603 putative substrate binding pocket (H-site) [chemical binding]; other site 716541001604 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 716541001605 Sulfate transporter family; Region: Sulfate_transp; cl19250 716541001606 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 716541001607 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 716541001608 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541001609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541001610 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 716541001611 putative dimerization interface [polypeptide binding]; other site 716541001612 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 716541001613 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 716541001614 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 716541001615 Na binding site [ion binding]; other site 716541001616 Predicted membrane protein [Function unknown]; Region: COG3162 716541001617 acetyl-CoA synthetase; Provisional; Region: PRK00174 716541001618 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 716541001619 active site 716541001620 CoA binding site [chemical binding]; other site 716541001621 acyl-activating enzyme (AAE) consensus motif; other site 716541001622 AMP binding site [chemical binding]; other site 716541001623 acetate binding site [chemical binding]; other site 716541001624 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 716541001625 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 716541001626 Sel1-like repeats; Region: SEL1; smart00671 716541001627 Hok/gef family; Region: HOK_GEF; pfam01848 716541001628 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 716541001629 molybdopterin cofactor binding site; other site 716541001630 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 716541001631 molybdopterin cofactor binding site; other site 716541001632 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 716541001633 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 716541001634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541001635 active site 716541001636 phosphorylation site [posttranslational modification] 716541001637 intermolecular recognition site; other site 716541001638 dimerization interface [polypeptide binding]; other site 716541001639 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541001640 DNA binding site [nucleotide binding] 716541001641 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 716541001642 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 716541001643 substrate binding site [chemical binding]; other site 716541001644 ATP binding site [chemical binding]; other site 716541001645 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 716541001646 intersubunit interface [polypeptide binding]; other site 716541001647 active site 716541001648 zinc binding site [ion binding]; other site 716541001649 Na+ binding site [ion binding]; other site 716541001650 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 716541001651 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541001652 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 716541001653 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 716541001654 putative ligand binding site [chemical binding]; other site 716541001655 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 716541001656 TM-ABC transporter signature motif; other site 716541001657 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 716541001658 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 716541001659 Walker A/P-loop; other site 716541001660 ATP binding site [chemical binding]; other site 716541001661 Q-loop/lid; other site 716541001662 ABC transporter signature motif; other site 716541001663 Walker B; other site 716541001664 D-loop; other site 716541001665 H-loop/switch region; other site 716541001666 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 716541001667 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 716541001668 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541001669 dimerization interface [polypeptide binding]; other site 716541001670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541001671 dimer interface [polypeptide binding]; other site 716541001672 phosphorylation site [posttranslational modification] 716541001673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541001674 ATP binding site [chemical binding]; other site 716541001675 Mg2+ binding site [ion binding]; other site 716541001676 G-X-G motif; other site 716541001677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541001678 active site 716541001679 phosphorylation site [posttranslational modification] 716541001680 intermolecular recognition site; other site 716541001681 dimerization interface [polypeptide binding]; other site 716541001682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541001683 Coenzyme A binding pocket [chemical binding]; other site 716541001684 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 716541001685 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541001686 Coenzyme A binding pocket [chemical binding]; other site 716541001687 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 716541001688 active site 716541001689 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 716541001690 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 716541001691 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 716541001692 active site 716541001693 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 716541001694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541001695 Walker A/P-loop; other site 716541001696 ATP binding site [chemical binding]; other site 716541001697 Q-loop/lid; other site 716541001698 ABC transporter signature motif; other site 716541001699 Walker B; other site 716541001700 D-loop; other site 716541001701 H-loop/switch region; other site 716541001702 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 716541001703 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716541001704 Walker A/P-loop; other site 716541001705 ATP binding site [chemical binding]; other site 716541001706 Q-loop/lid; other site 716541001707 ABC transporter signature motif; other site 716541001708 Walker B; other site 716541001709 D-loop; other site 716541001710 H-loop/switch region; other site 716541001711 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 716541001712 Phosphonate metabolizm protein PhnJ; Region: PhnJ; pfam06007 716541001713 Bacterial phosphonate metabolizm protein (PhnI); Region: PhnI; cl01456 716541001714 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 716541001715 Phosphonate metabolizm protein PhnG; Region: PhnG; pfam06754 716541001716 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 716541001717 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541001718 DNA-binding site [nucleotide binding]; DNA binding site 716541001719 UTRA domain; Region: UTRA; pfam07702 716541001720 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 716541001721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541001722 dimer interface [polypeptide binding]; other site 716541001723 conserved gate region; other site 716541001724 putative PBP binding loops; other site 716541001725 ABC-ATPase subunit interface; other site 716541001726 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 716541001727 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 716541001728 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 716541001729 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 716541001730 Walker A/P-loop; other site 716541001731 ATP binding site [chemical binding]; other site 716541001732 Q-loop/lid; other site 716541001733 ABC transporter signature motif; other site 716541001734 Walker B; other site 716541001735 D-loop; other site 716541001736 H-loop/switch region; other site 716541001737 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 716541001738 dimer interface [polypeptide binding]; other site 716541001739 hypothetical protein; Provisional; Region: PRK10220 716541001740 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 716541001741 PhnA protein; Region: PhnA; pfam03831 716541001742 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 716541001743 G1 box; other site 716541001744 GTP/Mg2+ binding site [chemical binding]; other site 716541001745 G2 box; other site 716541001746 Switch I region; other site 716541001747 G3 box; other site 716541001748 Switch II region; other site 716541001749 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 716541001750 G2 box; other site 716541001751 Switch I region; other site 716541001752 G3 box; other site 716541001753 Switch II region; other site 716541001754 G4 box; other site 716541001755 G5 box; other site 716541001756 YjcZ-like protein; Region: YjcZ; pfam13990 716541001757 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 716541001758 proline/glycine betaine transporter; Provisional; Region: PRK10642 716541001759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541001760 putative substrate translocation pore; other site 716541001761 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 716541001762 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 716541001763 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 716541001764 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 716541001765 PapC N-terminal domain; Region: PapC_N; pfam13954 716541001766 Outer membrane usher protein; Region: Usher; pfam00577 716541001767 PapC C-terminal domain; Region: PapC_C; pfam13953 716541001768 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 716541001769 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 716541001770 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 716541001771 Fimbrial protein; Region: Fimbrial; cl01416 716541001772 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 716541001773 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 716541001774 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 716541001775 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 716541001776 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 716541001777 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 716541001778 putative active site [active] 716541001779 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 716541001780 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 716541001781 Walker A/P-loop; other site 716541001782 ATP binding site [chemical binding]; other site 716541001783 Q-loop/lid; other site 716541001784 ABC transporter signature motif; other site 716541001785 Walker B; other site 716541001786 D-loop; other site 716541001787 H-loop/switch region; other site 716541001788 macrolide transporter subunit MacA; Provisional; Region: PRK11578 716541001789 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541001790 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541001791 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 716541001792 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 716541001793 Walker A/P-loop; other site 716541001794 ATP binding site [chemical binding]; other site 716541001795 Q-loop/lid; other site 716541001796 ABC transporter signature motif; other site 716541001797 Walker B; other site 716541001798 D-loop; other site 716541001799 H-loop/switch region; other site 716541001800 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 716541001801 FtsX-like permease family; Region: FtsX; pfam02687 716541001802 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 716541001803 Outer membrane efflux protein; Region: OEP; pfam02321 716541001804 Outer membrane efflux protein; Region: OEP; pfam02321 716541001805 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 716541001806 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 716541001807 dimer interface [polypeptide binding]; other site 716541001808 active site 716541001809 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 716541001810 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 716541001811 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 716541001812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716541001813 NAD(P) binding site [chemical binding]; other site 716541001814 active site 716541001815 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 716541001816 Zn2+ binding site [ion binding]; other site 716541001817 Mg2+ binding site [ion binding]; other site 716541001818 putative transposase OrfB; Reviewed; Region: PHA02517 716541001819 HTH-like domain; Region: HTH_21; pfam13276 716541001820 Integrase core domain; Region: rve; pfam00665 716541001821 Integrase core domain; Region: rve_2; pfam13333 716541001822 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541001823 Transposase; Region: HTH_Tnp_1; pfam01527 716541001824 Transposase domain (DUF772); Region: DUF772; pfam05598 716541001825 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 716541001826 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 716541001827 DDE superfamily endonuclease; Region: DDE_Tnp_4; cl17710 716541001828 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 716541001829 PAS domain; Region: PAS_9; pfam13426 716541001830 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716541001831 putative active site [active] 716541001832 heme pocket [chemical binding]; other site 716541001833 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716541001834 PAS domain; Region: PAS_9; pfam13426 716541001835 putative active site [active] 716541001836 heme pocket [chemical binding]; other site 716541001837 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541001838 metal binding site [ion binding]; metal-binding site 716541001839 active site 716541001840 I-site; other site 716541001841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 716541001842 HTH-like domain; Region: HTH_21; pfam13276 716541001843 Integrase core domain; Region: rve; pfam00665 716541001844 Integrase core domain; Region: rve_3; pfam13683 716541001845 Transposase; Region: HTH_Tnp_1; pfam01527 716541001846 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 716541001847 active site 716541001848 DNA binding site [nucleotide binding] 716541001849 Int/Topo IB signature motif; other site 716541001850 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 716541001851 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 716541001852 P-loop; other site 716541001853 Magnesium ion binding site [ion binding]; other site 716541001854 replicative DNA helicase; Region: DnaB; TIGR00665 716541001855 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 716541001856 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 716541001857 Walker A motif; other site 716541001858 ATP binding site [chemical binding]; other site 716541001859 Walker B motif; other site 716541001860 DNA binding loops [nucleotide binding] 716541001861 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 716541001862 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 716541001863 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 716541001864 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 716541001865 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 716541001866 Helix-turn-helix domain; Region: HTH_36; pfam13730 716541001867 integrating conjugative element protein, PFL_4669 family; Region: ICE_PFL4669; TIGR03761 716541001868 DNA topoisomerase III; Provisional; Region: PRK07726 716541001869 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 716541001870 active site 716541001871 putative interdomain interaction site [polypeptide binding]; other site 716541001872 putative metal-binding site [ion binding]; other site 716541001873 putative nucleotide binding site [chemical binding]; other site 716541001874 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 716541001875 domain I; other site 716541001876 DNA binding groove [nucleotide binding] 716541001877 phosphate binding site [ion binding]; other site 716541001878 domain II; other site 716541001879 domain III; other site 716541001880 nucleotide binding site [chemical binding]; other site 716541001881 catalytic site [active] 716541001882 domain IV; other site 716541001883 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 716541001884 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 716541001885 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 716541001886 dimer interface [polypeptide binding]; other site 716541001887 ssDNA binding site [nucleotide binding]; other site 716541001888 tetramer (dimer of dimers) interface [polypeptide binding]; other site 716541001889 putative single-stranded DNA-binding protein; Region: PHA01740 716541001890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 716541001891 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 716541001892 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 716541001893 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 716541001894 PilM; Region: PilM; pfam07419 716541001895 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 716541001896 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 716541001897 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 716541001898 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 716541001899 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 716541001900 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 716541001901 Walker A motif; other site 716541001902 ATP binding site [chemical binding]; other site 716541001903 Walker B motif; other site 716541001904 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 716541001905 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 716541001906 PilS N terminal; Region: PilS; pfam08805 716541001907 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 716541001908 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716541001909 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716541001910 catalytic residue [active] 716541001911 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 716541001912 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 716541001913 Rci recombinase, C-terminal catalytic domain. Rci enzymes are found in IncI1 incompatibility group plasmids such as R64. These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796 716541001914 catalytic residues [active] 716541001915 Int/Topo IB signature motif; other site 716541001916 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 716541001917 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 716541001918 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716541001919 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716541001920 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 716541001921 Restriction endonuclease; Region: Mrr_cat; pfam04471 716541001922 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 716541001923 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 716541001924 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 716541001925 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; cl19622 716541001926 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 716541001927 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 716541001928 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 716541001929 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 716541001930 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 716541001931 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 716541001932 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 716541001933 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 716541001934 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 716541001935 PerC transcriptional activator; Region: PerC; pfam06069 716541001936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541001937 ATP binding site [chemical binding]; other site 716541001938 Mg2+ binding site [ion binding]; other site 716541001939 G-X-G motif; other site 716541001940 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 716541001941 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 716541001942 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 716541001943 PhoU domain; Region: PhoU; pfam01895 716541001944 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 716541001945 PHP-associated; Region: PHP_C; pfam13263 716541001946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541001947 P-loop containing region of AAA domain; Region: AAA_29; cl17516 716541001948 Walker A/P-loop; other site 716541001949 ATP binding site [chemical binding]; other site 716541001950 Q-loop/lid; other site 716541001951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541001952 ABC transporter signature motif; other site 716541001953 Walker B; other site 716541001954 D-loop; other site 716541001955 H-loop/switch region; other site 716541001956 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 716541001957 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 716541001958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541001959 Coenzyme A binding pocket [chemical binding]; other site 716541001960 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 716541001961 Protein tyrosine phosphatase, catalytic domain motif; Region: PTPc_motif; smart00404 716541001962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541001963 Transposase; Region: HTH_Tnp_1; cl17663 716541001964 Integrase core domain; Region: rve; pfam00665 716541001965 DDE domain; Region: DDE_Tnp_IS240; pfam13610 716541001966 Integrase core domain; Region: rve_3; pfam13683 716541001967 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 716541001968 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 716541001969 active site 716541001970 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 716541001971 catalytic residues [active] 716541001972 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 716541001973 Citrate transporter; Region: CitMHS; pfam03600 716541001974 transmembrane helices; other site 716541001975 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 716541001976 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 716541001977 P loop; other site 716541001978 Nucleotide binding site [chemical binding]; other site 716541001979 DTAP/Switch II; other site 716541001980 Switch I; other site 716541001981 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 716541001982 P loop; other site 716541001983 Nucleotide binding site [chemical binding]; other site 716541001984 DTAP/Switch II; other site 716541001985 Switch I; other site 716541001986 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 716541001987 Low molecular weight phosphatase family; Region: LMWPc; cd00115 716541001988 active site 716541001989 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716541001990 dimerization interface [polypeptide binding]; other site 716541001991 putative DNA binding site [nucleotide binding]; other site 716541001992 putative Zn2+ binding site [ion binding]; other site 716541001993 Predicted permeases [General function prediction only]; Region: COG0701 716541001994 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 716541001995 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 716541001996 Ligand Binding Site [chemical binding]; other site 716541001997 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 716541001998 Ligand Binding Site [chemical binding]; other site 716541001999 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 716541002000 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 716541002001 Sulfate transporter family; Region: Sulfate_transp; pfam00916 716541002002 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 716541002003 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 716541002004 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 716541002005 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 716541002006 Integrase core domain; Region: rve; pfam00665 716541002007 DDE domain; Region: DDE_Tnp_IS240; pfam13610 716541002008 Integrase core domain; Region: rve_3; pfam13683 716541002009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541002010 Transposase; Region: HTH_Tnp_1; cl17663 716541002011 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 716541002012 active site 1 [active] 716541002013 active site 2 [active] 716541002014 Ferritin-like domain; Region: Ferritin; pfam00210 716541002015 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 716541002016 dimerization interface [polypeptide binding]; other site 716541002017 DPS ferroxidase diiron center [ion binding]; other site 716541002018 ion pore; other site 716541002019 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716541002020 dimerization interface [polypeptide binding]; other site 716541002021 putative DNA binding site [nucleotide binding]; other site 716541002022 putative Zn2+ binding site [ion binding]; other site 716541002023 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 716541002024 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716541002025 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541002026 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 716541002027 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 716541002028 active site residue [active] 716541002029 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 716541002030 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 716541002031 DHH family; Region: DHH; pfam01368 716541002032 DHHA2 domain; Region: DHHA2; pfam02833 716541002033 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 716541002034 Ligand Binding Site [chemical binding]; other site 716541002035 enolase; Provisional; Region: eno; PRK00077 716541002036 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 716541002037 dimer interface [polypeptide binding]; other site 716541002038 metal binding site [ion binding]; metal-binding site 716541002039 substrate binding pocket [chemical binding]; other site 716541002040 chromosome condensation membrane protein; Provisional; Region: PRK14196 716541002041 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 716541002042 Ligand Binding Site [chemical binding]; other site 716541002043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541002044 Walker A/P-loop; other site 716541002045 ATP binding site [chemical binding]; other site 716541002046 Q-loop/lid; other site 716541002047 ABC transporter signature motif; other site 716541002048 Walker B; other site 716541002049 D-loop; other site 716541002050 H-loop/switch region; other site 716541002051 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 716541002052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541002053 Walker A/P-loop; other site 716541002054 ATP binding site [chemical binding]; other site 716541002055 Q-loop/lid; other site 716541002056 ABC transporter signature motif; other site 716541002057 Walker B; other site 716541002058 D-loop; other site 716541002059 H-loop/switch region; other site 716541002060 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 716541002061 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541002062 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541002063 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 716541002064 FRG domain; Region: FRG; cl07460 716541002065 Phage integrase, N-terminal; Region: Phage_int_SAM_2; pfam12834 716541002066 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 716541002067 active site 716541002068 Int/Topo IB signature motif; other site 716541002069 catalytic residues [active] 716541002070 DNA binding site [nucleotide binding] 716541002071 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 716541002072 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 716541002073 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 716541002074 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 716541002075 OsmC-like protein; Region: OsmC; cl00767 716541002076 IS2 transposase TnpB; Reviewed; Region: PRK09409 716541002077 HTH-like domain; Region: HTH_21; pfam13276 716541002078 Integrase core domain; Region: rve; pfam00665 716541002079 Integrase core domain; Region: rve_3; pfam13683 716541002080 Transposase; Region: HTH_Tnp_1; cl17663 716541002081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541002082 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 716541002083 active site 716541002084 putative transposase OrfB; Reviewed; Region: PHA02517 716541002085 HTH-like domain; Region: HTH_21; pfam13276 716541002086 Integrase core domain; Region: rve; pfam00665 716541002087 Integrase core domain; Region: rve_3; pfam13683 716541002088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541002089 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 716541002090 ADP-ribose binding site [chemical binding]; other site 716541002091 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 716541002092 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 716541002093 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 716541002094 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 716541002095 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 716541002096 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 716541002097 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 716541002098 active site 716541002099 catalytic residues [active] 716541002100 DNA binding site [nucleotide binding] 716541002101 Int/Topo IB signature motif; other site 716541002102 putative transcriptional regulator; Provisional; Region: PRK11640 716541002103 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 716541002104 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 716541002105 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 716541002106 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 716541002107 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 716541002108 DsbD alpha interface [polypeptide binding]; other site 716541002109 catalytic residues [active] 716541002110 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 716541002111 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 716541002112 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 716541002113 Aspartase; Region: Aspartase; cd01357 716541002114 active sites [active] 716541002115 tetramer interface [polypeptide binding]; other site 716541002116 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 716541002117 putative transporter; Provisional; Region: PRK11021 716541002118 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 716541002119 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 716541002120 oligomerisation interface [polypeptide binding]; other site 716541002121 mobile loop; other site 716541002122 roof hairpin; other site 716541002123 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 716541002124 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 716541002125 ring oligomerisation interface [polypeptide binding]; other site 716541002126 ATP/Mg binding site [chemical binding]; other site 716541002127 stacking interactions; other site 716541002128 hinge regions; other site 716541002129 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541002130 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541002131 hypothetical protein; Provisional; Region: PRK10519 716541002132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 716541002133 Nucleoside recognition; Region: Gate; pfam07670 716541002134 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 716541002135 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 716541002136 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716541002137 FeS/SAM binding site; other site 716541002138 elongation factor P; Validated; Region: PRK00529 716541002139 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 716541002140 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 716541002141 RNA binding site [nucleotide binding]; other site 716541002142 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 716541002143 RNA binding site [nucleotide binding]; other site 716541002144 Entericidin EcnA/B family; Region: Entericidin; cl02322 716541002145 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 716541002146 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 716541002147 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541002148 DNA binding residues [nucleotide binding] 716541002149 dimerization interface [polypeptide binding]; other site 716541002150 multidrug efflux system protein; Provisional; Region: PRK11431 716541002151 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 716541002152 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 716541002153 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 716541002154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541002155 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541002156 dimerization interface [polypeptide binding]; other site 716541002157 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 716541002158 Iron-sulfur protein interface; other site 716541002159 proximal quinone binding site [chemical binding]; other site 716541002160 C-subunit interface; other site 716541002161 distal quinone binding site; other site 716541002162 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 716541002163 D-subunit interface [polypeptide binding]; other site 716541002164 Iron-sulfur protein interface; other site 716541002165 proximal quinone binding site [chemical binding]; other site 716541002166 distal quinone binding site [chemical binding]; other site 716541002167 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 716541002168 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 716541002169 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 716541002170 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 716541002171 L-aspartate oxidase; Provisional; Region: PRK06175 716541002172 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 716541002173 poxB regulator PoxA; Provisional; Region: PRK09350 716541002174 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 716541002175 motif 1; other site 716541002176 dimer interface [polypeptide binding]; other site 716541002177 active site 716541002178 motif 2; other site 716541002179 motif 3; other site 716541002180 putative mechanosensitive channel protein; Provisional; Region: PRK10929 716541002181 Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280 716541002182 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 716541002183 Mechanosensitive ion channel; Region: MS_channel; pfam00924 716541002184 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 716541002185 GTPase RsgA; Reviewed; Region: PRK12288 716541002186 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 716541002187 RNA binding site [nucleotide binding]; other site 716541002188 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 716541002189 GTPase/Zn-binding domain interface [polypeptide binding]; other site 716541002190 GTP/Mg2+ binding site [chemical binding]; other site 716541002191 G4 box; other site 716541002192 G5 box; other site 716541002193 G1 box; other site 716541002194 Switch I region; other site 716541002195 G2 box; other site 716541002196 G3 box; other site 716541002197 Switch II region; other site 716541002198 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 716541002199 catalytic site [active] 716541002200 putative active site [active] 716541002201 putative substrate binding site [chemical binding]; other site 716541002202 dimer interface [polypeptide binding]; other site 716541002203 epoxyqueuosine reductase; Region: TIGR00276 716541002204 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 716541002205 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 716541002206 putative carbohydrate kinase; Provisional; Region: PRK10565 716541002207 Uncharacterized conserved protein [Function unknown]; Region: COG0062 716541002208 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 716541002209 putative substrate binding site [chemical binding]; other site 716541002210 putative ATP binding site [chemical binding]; other site 716541002211 ADP-binding protein; Provisional; Region: PRK10646 716541002212 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 716541002213 AMIN domain; Region: AMIN; pfam11741 716541002214 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 716541002215 active site 716541002216 metal binding site [ion binding]; metal-binding site 716541002217 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 716541002218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541002219 ATP binding site [chemical binding]; other site 716541002220 Mg2+ binding site [ion binding]; other site 716541002221 G-X-G motif; other site 716541002222 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 716541002223 ATP binding site [chemical binding]; other site 716541002224 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 716541002225 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 716541002226 AAA domain; Region: AAA_33; pfam13671 716541002227 bacterial Hfq-like; Region: Hfq; cd01716 716541002228 hexamer interface [polypeptide binding]; other site 716541002229 Sm1 motif; other site 716541002230 RNA binding site [nucleotide binding]; other site 716541002231 Sm2 motif; other site 716541002232 GTPase HflX; Provisional; Region: PRK11058 716541002233 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 716541002234 HflX GTPase family; Region: HflX; cd01878 716541002235 G1 box; other site 716541002236 GTP/Mg2+ binding site [chemical binding]; other site 716541002237 Switch I region; other site 716541002238 G2 box; other site 716541002239 G3 box; other site 716541002240 Switch II region; other site 716541002241 G4 box; other site 716541002242 G5 box; other site 716541002243 FtsH protease regulator HflK; Provisional; Region: PRK10930 716541002244 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 716541002245 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 716541002246 HflC protein; Region: hflC; TIGR01932 716541002247 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 716541002248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 716541002249 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 716541002250 GDP-binding site [chemical binding]; other site 716541002251 ACT binding site; other site 716541002252 IMP binding site; other site 716541002253 transcriptional repressor NsrR; Provisional; Region: PRK11014 716541002254 Rrf2 family protein; Region: rrf2_super; TIGR00738 716541002255 exoribonuclease R; Provisional; Region: PRK11642 716541002256 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 716541002257 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 716541002258 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 716541002259 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 716541002260 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 716541002261 RNA binding site [nucleotide binding]; other site 716541002262 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 716541002263 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 716541002264 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 716541002265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541002266 metabolite-proton symporter; Region: 2A0106; TIGR00883 716541002267 putative substrate translocation pore; other site 716541002268 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 716541002269 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 716541002270 FAD binding site [chemical binding]; other site 716541002271 substrate binding site [chemical binding]; other site 716541002272 catalytic residues [active] 716541002273 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541002274 dimerization interface [polypeptide binding]; other site 716541002275 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 716541002276 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716541002277 dimer interface [polypeptide binding]; other site 716541002278 putative CheW interface [polypeptide binding]; other site 716541002279 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 716541002280 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 716541002281 esterase; Provisional; Region: PRK10566 716541002282 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 716541002283 transcriptional repressor UlaR; Provisional; Region: PRK13509 716541002284 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 716541002285 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 716541002286 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 716541002287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 716541002288 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 716541002289 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 716541002290 active site 716541002291 phosphorylation site [posttranslational modification] 716541002292 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 716541002293 active site 716541002294 dimer interface [polypeptide binding]; other site 716541002295 magnesium binding site [ion binding]; other site 716541002296 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 716541002297 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 716541002298 AP (apurinic/apyrimidinic) site pocket; other site 716541002299 DNA interaction; other site 716541002300 Metal-binding active site; metal-binding site 716541002301 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 716541002302 intersubunit interface [polypeptide binding]; other site 716541002303 active site 716541002304 Zn2+ binding site [ion binding]; other site 716541002305 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 716541002306 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 716541002307 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 716541002308 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 716541002309 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 716541002310 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 716541002311 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 716541002312 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 716541002313 EamA-like transporter family; Region: EamA; pfam00892 716541002314 EamA-like transporter family; Region: EamA; pfam00892 716541002315 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 716541002316 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 716541002317 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 716541002318 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 716541002319 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 716541002320 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 716541002321 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 716541002322 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 716541002323 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 716541002324 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 716541002325 Hemerythrin-like domain; Region: Hr-like; cd12108 716541002326 Fe binding site [ion binding]; other site 716541002327 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 716541002328 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 716541002329 dimer interface [polypeptide binding]; other site 716541002330 ligand binding site [chemical binding]; other site 716541002331 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541002332 dimerization interface [polypeptide binding]; other site 716541002333 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716541002334 dimer interface [polypeptide binding]; other site 716541002335 putative CheW interface [polypeptide binding]; other site 716541002336 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 716541002337 EamA-like transporter family; Region: EamA; pfam00892 716541002338 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 716541002339 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 716541002340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541002341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541002342 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 716541002343 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 716541002344 conserved cys residue [active] 716541002345 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 716541002346 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541002347 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541002348 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 716541002349 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 716541002350 active site 716541002351 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 716541002352 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 716541002353 NADP binding site [chemical binding]; other site 716541002354 Predicted transcriptional regulators [Transcription]; Region: COG1733 716541002355 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 716541002356 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 716541002357 active site 716541002358 metal binding site [ion binding]; metal-binding site 716541002359 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 716541002360 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 716541002361 active site 716541002362 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 716541002363 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 716541002364 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 716541002365 Domain of unknown function DUF21; Region: DUF21; pfam01595 716541002366 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 716541002367 Transporter associated domain; Region: CorC_HlyC; smart01091 716541002368 AAA ATPase domain; Region: AAA_15; pfam13175 716541002369 AAA domain; Region: AAA_23; pfam13476 716541002370 AAA domain; Region: AAA_21; pfam13304 716541002371 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 716541002372 putative active site [active] 716541002373 putative metal-binding site [ion binding]; other site 716541002374 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 716541002375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541002376 putative substrate translocation pore; other site 716541002377 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 716541002378 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 716541002379 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 716541002380 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 716541002381 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 716541002382 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 716541002383 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 716541002384 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 716541002385 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 716541002386 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 716541002387 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 716541002388 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 716541002389 Transcriptional regulators [Transcription]; Region: PurR; COG1609 716541002390 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541002391 DNA binding site [nucleotide binding] 716541002392 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 716541002393 ligand binding site [chemical binding]; other site 716541002394 dimerization interface [polypeptide binding]; other site 716541002395 methionine sulfoxide reductase A; Provisional; Region: PRK00058 716541002396 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 716541002397 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 716541002398 Surface antigen; Region: Bac_surface_Ag; pfam01103 716541002399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 716541002400 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 716541002401 Family of unknown function (DUF490); Region: DUF490; pfam04357 716541002402 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 716541002403 dimerization interface [polypeptide binding]; other site 716541002404 putative active site pocket [active] 716541002405 putative catalytic residue [active] 716541002406 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 716541002407 dimer interface [polypeptide binding]; other site 716541002408 substrate binding site [chemical binding]; other site 716541002409 metal binding sites [ion binding]; metal-binding site 716541002410 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 716541002411 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 716541002412 putative ligand binding site [chemical binding]; other site 716541002413 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 716541002414 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 716541002415 Walker A/P-loop; other site 716541002416 ATP binding site [chemical binding]; other site 716541002417 Q-loop/lid; other site 716541002418 ABC transporter signature motif; other site 716541002419 Walker B; other site 716541002420 D-loop; other site 716541002421 H-loop/switch region; other site 716541002422 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 716541002423 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 716541002424 TM-ABC transporter signature motif; other site 716541002425 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 716541002426 TM-ABC transporter signature motif; other site 716541002427 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 716541002428 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 716541002429 dimer interface [polypeptide binding]; other site 716541002430 ligand binding site [chemical binding]; other site 716541002431 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541002432 dimerization interface [polypeptide binding]; other site 716541002433 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716541002434 dimer interface [polypeptide binding]; other site 716541002435 putative CheW interface [polypeptide binding]; other site 716541002436 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541002437 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541002438 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 716541002439 AMP binding site [chemical binding]; other site 716541002440 metal binding site [ion binding]; metal-binding site 716541002441 active site 716541002442 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 716541002443 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 716541002444 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 716541002445 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 716541002446 hypothetical protein; Provisional; Region: PRK05255 716541002447 peptidase PmbA; Provisional; Region: PRK11040 716541002448 Cytochrome b562; Region: Cytochrom_B562; cl01546 716541002449 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 716541002450 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 716541002451 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 716541002452 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 716541002453 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 716541002454 dihydroorotase; Provisional; Region: PRK09237 716541002455 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 716541002456 active site 716541002457 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 716541002458 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 716541002459 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 716541002460 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 716541002461 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 716541002462 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 716541002463 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716541002464 FeS/SAM binding site; other site 716541002465 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 716541002466 ATP cone domain; Region: ATP-cone; pfam03477 716541002467 Class III ribonucleotide reductase; Region: RNR_III; cd01675 716541002468 effector binding site; other site 716541002469 active site 716541002470 Zn binding site [ion binding]; other site 716541002471 glycine loop; other site 716541002472 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 716541002473 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 716541002474 Ca binding site [ion binding]; other site 716541002475 active site 716541002476 catalytic site [active] 716541002477 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 716541002478 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 716541002479 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 716541002480 active site turn [active] 716541002481 phosphorylation site [posttranslational modification] 716541002482 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 716541002483 trehalose repressor; Provisional; Region: treR; PRK09492 716541002484 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541002485 DNA binding site [nucleotide binding] 716541002486 domain linker motif; other site 716541002487 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 716541002488 dimerization interface [polypeptide binding]; other site 716541002489 ligand binding site [chemical binding]; other site 716541002490 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 716541002491 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 716541002492 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 716541002493 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 716541002494 Soluble P-type ATPase [General function prediction only]; Region: COG4087 716541002495 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 716541002496 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 716541002497 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 716541002498 active site 716541002499 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 716541002500 Chitin binding domain; Region: Chitin_bind_3; pfam03067 716541002501 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 716541002502 homotrimer interaction site [polypeptide binding]; other site 716541002503 putative active site [active] 716541002504 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 716541002505 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 716541002506 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 716541002507 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 716541002508 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 716541002509 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 716541002510 Arginine repressor [Transcription]; Region: ArgR; COG1438 716541002511 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 716541002512 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 716541002513 Predicted membrane protein [Function unknown]; Region: COG1288 716541002514 ornithine carbamoyltransferase; Validated; Region: PRK02102 716541002515 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 716541002516 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 716541002517 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 716541002518 putative substrate binding site [chemical binding]; other site 716541002519 nucleotide binding site [chemical binding]; other site 716541002520 nucleotide binding site [chemical binding]; other site 716541002521 homodimer interface [polypeptide binding]; other site 716541002522 arginine deiminase; Provisional; Region: PRK01388 716541002523 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 716541002524 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 716541002525 inhibitor site; inhibition site 716541002526 active site 716541002527 dimer interface [polypeptide binding]; other site 716541002528 catalytic residue [active] 716541002529 putative dehydratase; Provisional; Region: PRK08211 716541002530 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 716541002531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541002532 putative substrate translocation pore; other site 716541002533 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 716541002534 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 716541002535 inhibitor binding site; inhibition site 716541002536 active site 716541002537 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 716541002538 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 716541002539 Transcriptional regulator [Transcription]; Region: IclR; COG1414 716541002540 Bacterial transcriptional regulator; Region: IclR; pfam01614 716541002541 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 716541002542 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 716541002543 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 716541002544 RNase E inhibitor protein; Provisional; Region: PRK11191 716541002545 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE); Region: MiaE; pfam06175 716541002546 dinuclear metal binding motif [ion binding]; other site 716541002547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541002548 Transposase; Region: HTH_Tnp_1; pfam01527 716541002549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 716541002550 HTH-like domain; Region: HTH_21; pfam13276 716541002551 Integrase core domain; Region: rve; pfam00665 716541002552 Integrase core domain; Region: rve_3; pfam13683 716541002553 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 716541002554 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541002555 Transposase; Region: HTH_Tnp_1; cl17663 716541002556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541002557 IS2 transposase TnpB; Reviewed; Region: PRK09409 716541002558 HTH-like domain; Region: HTH_21; pfam13276 716541002559 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541002560 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 716541002561 Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl19592 716541002562 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 716541002563 Ash protein family; Region: Phage_ASH; pfam10554 716541002564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 716541002565 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 716541002566 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 716541002567 D5 N terminal like; Region: D5_N; smart00885 716541002568 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 716541002569 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 716541002570 HNH endonuclease; Region: HNH_2; pfam13391 716541002571 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 716541002572 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 716541002573 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 716541002574 active site 716541002575 HIGH motif; other site 716541002576 dimer interface [polypeptide binding]; other site 716541002577 KMSKS motif; other site 716541002578 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 716541002579 dimer interface [polypeptide binding]; other site 716541002580 Mn binding site [ion binding]; other site 716541002581 K binding site [ion binding]; other site 716541002582 Transcriptional regulators [Transcription]; Region: PurR; COG1609 716541002583 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541002584 DNA binding site [nucleotide binding] 716541002585 domain linker motif; other site 716541002586 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 716541002587 Sugar-binding cellulase-like; Region: Cellulase-like; cl19200 716541002588 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 716541002589 putative symporter YagG; Provisional; Region: PRK09669; cl15392 716541002590 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 716541002591 Putative lysophospholipase; Region: Hydrolase_4; cl19140 716541002592 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 716541002593 Transmembrane secretion effector; Region: MFS_3; pfam05977 716541002594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541002595 putative substrate translocation pore; other site 716541002596 Predicted membrane protein [Function unknown]; Region: COG2259 716541002597 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 716541002598 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 716541002599 active site 716541002600 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 716541002601 catalytic triad [active] 716541002602 dimer interface [polypeptide binding]; other site 716541002603 conserved cis-peptide bond; other site 716541002604 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 716541002605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4317 716541002606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541002607 active site 716541002608 phosphorylation site [posttranslational modification] 716541002609 intermolecular recognition site; other site 716541002610 dimerization interface [polypeptide binding]; other site 716541002611 Catalytic domain of Protein Kinases; Region: PKc; cd00180 716541002612 active site 716541002613 ATP binding site [chemical binding]; other site 716541002614 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 716541002615 substrate binding site [chemical binding]; other site 716541002616 activation loop (A-loop); other site 716541002617 AAA ATPase domain; Region: AAA_16; pfam13191 716541002618 Predicted ATPase [General function prediction only]; Region: COG3899 716541002619 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 716541002620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716541002621 PAS fold; Region: PAS_3; pfam08447 716541002622 putative active site [active] 716541002623 heme pocket [chemical binding]; other site 716541002624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541002625 dimer interface [polypeptide binding]; other site 716541002626 phosphorylation site [posttranslational modification] 716541002627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541002628 ATP binding site [chemical binding]; other site 716541002629 Mg2+ binding site [ion binding]; other site 716541002630 G-X-G motif; other site 716541002631 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 716541002632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541002633 active site 716541002634 phosphorylation site [posttranslational modification] 716541002635 intermolecular recognition site; other site 716541002636 dimerization interface [polypeptide binding]; other site 716541002637 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541002638 DNA binding residues [nucleotide binding] 716541002639 dimerization interface [polypeptide binding]; other site 716541002640 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 716541002641 active site 716541002642 metal binding site [ion binding]; metal-binding site 716541002643 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 716541002644 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 716541002645 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 716541002646 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 716541002647 oligomer interface [polypeptide binding]; other site 716541002648 active site residues [active] 716541002649 Uncharacterized conserved protein [Function unknown]; Region: COG2850 716541002650 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 716541002651 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541002652 DNA-binding site [nucleotide binding]; DNA binding site 716541002653 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716541002654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541002655 homodimer interface [polypeptide binding]; other site 716541002656 catalytic residue [active] 716541002657 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 716541002658 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 716541002659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541002660 DNA-binding site [nucleotide binding]; DNA binding site 716541002661 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716541002662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541002663 homodimer interface [polypeptide binding]; other site 716541002664 catalytic residue [active] 716541002665 Uncharacterized conserved protein [Function unknown]; Region: COG2128 716541002666 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 716541002667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541002668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541002669 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541002670 dimerization interface [polypeptide binding]; other site 716541002671 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 716541002672 NAD binding site [chemical binding]; other site 716541002673 catalytic residues [active] 716541002674 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 716541002675 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 716541002676 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 716541002677 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 716541002678 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716541002679 dimerization interface [polypeptide binding]; other site 716541002680 putative DNA binding site [nucleotide binding]; other site 716541002681 putative Zn2+ binding site [ion binding]; other site 716541002682 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 716541002683 Transcriptional regulators [Transcription]; Region: MarR; COG1846 716541002684 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 716541002685 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541002686 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541002687 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 716541002688 Predicted membrane protein [Function unknown]; Region: COG2733 716541002689 Protein of unknown function (DUF445); Region: DUF445; pfam04286 716541002690 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 716541002691 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 716541002692 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 716541002693 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 716541002694 NAD(P) binding site [chemical binding]; other site 716541002695 catalytic residues [active] 716541002696 YfaZ precursor; Region: YfaZ; pfam07437 716541002697 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 716541002698 SdiA-regulated; Region: SdiA-regulated; cl19046 716541002699 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541002700 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 716541002701 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 716541002702 P-loop, Walker A motif; other site 716541002703 Base recognition motif; other site 716541002704 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 716541002705 Uncharacterized small protein [Function unknown]; Region: COG2879 716541002706 carbon starvation protein A; Provisional; Region: PRK15015 716541002707 Carbon starvation protein CstA; Region: CstA; pfam02554 716541002708 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 716541002709 Predicted transcriptional regulator [Transcription]; Region: COG2378 716541002710 HTH domain; Region: HTH_11; cl17392 716541002711 WYL domain; Region: WYL; pfam13280 716541002712 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 716541002713 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 716541002714 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 716541002715 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 716541002716 Cupin domain; Region: Cupin_2; pfam07883 716541002717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541002718 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 716541002719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541002720 putative substrate translocation pore; other site 716541002721 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 716541002722 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 716541002723 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 716541002724 putative substrate binding pocket [chemical binding]; other site 716541002725 trimer interface [polypeptide binding]; other site 716541002726 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 716541002727 putative active site [active] 716541002728 putative metal binding site [ion binding]; other site 716541002729 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 716541002730 NAD binding site [chemical binding]; other site 716541002731 catalytic residues [active] 716541002732 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 716541002733 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 716541002734 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 716541002735 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 716541002736 Transcriptional regulators [Transcription]; Region: MarR; COG1846 716541002737 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 716541002738 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 716541002739 dimer interface [polypeptide binding]; other site 716541002740 ligand binding site [chemical binding]; other site 716541002741 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541002742 dimerization interface [polypeptide binding]; other site 716541002743 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716541002744 dimer interface [polypeptide binding]; other site 716541002745 putative CheW interface [polypeptide binding]; other site 716541002746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541002747 Coenzyme A binding pocket [chemical binding]; other site 716541002748 phosphoglycerol transferase I; Provisional; Region: PRK03776 716541002749 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 716541002750 hypothetical protein; Provisional; Region: PRK11667 716541002751 DNA replication protein DnaC; Validated; Region: PRK07952 716541002752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541002753 Walker A motif; other site 716541002754 ATP binding site [chemical binding]; other site 716541002755 Walker B motif; other site 716541002756 primosomal protein DnaI; Provisional; Region: PRK02854 716541002757 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 716541002758 Transcriptional regulators [Transcription]; Region: MarR; COG1846 716541002759 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 716541002760 putative Zn2+ binding site [ion binding]; other site 716541002761 putative DNA binding site [nucleotide binding]; other site 716541002762 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 716541002763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716541002764 hypothetical protein; Provisional; Region: PRK09917 716541002765 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 716541002766 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541002767 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541002768 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541002769 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 716541002770 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 716541002771 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541002772 DNA binding residues [nucleotide binding] 716541002773 dimerization interface [polypeptide binding]; other site 716541002774 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 716541002775 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541002776 DNA binding residues [nucleotide binding] 716541002777 dimerization interface [polypeptide binding]; other site 716541002778 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 716541002779 putative deacylase active site [active] 716541002780 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 716541002781 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 716541002782 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 716541002783 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 716541002784 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541002785 metal binding site [ion binding]; metal-binding site 716541002786 active site 716541002787 I-site; other site 716541002788 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 716541002789 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 716541002790 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 716541002791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541002792 S-adenosylmethionine binding site [chemical binding]; other site 716541002793 DNA polymerase III subunit psi; Validated; Region: PRK06856 716541002794 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 716541002795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541002796 Coenzyme A binding pocket [chemical binding]; other site 716541002797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 716541002798 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 716541002799 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541002800 motif II; other site 716541002801 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 716541002802 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 716541002803 G1 box; other site 716541002804 putative GEF interaction site [polypeptide binding]; other site 716541002805 GTP/Mg2+ binding site [chemical binding]; other site 716541002806 Switch I region; other site 716541002807 G2 box; other site 716541002808 G3 box; other site 716541002809 Switch II region; other site 716541002810 G4 box; other site 716541002811 G5 box; other site 716541002812 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 716541002813 Elongation Factor G, domain II; Region: EFG_II; pfam14492 716541002814 periplasmic protein; Provisional; Region: PRK10568 716541002815 BON domain; Region: BON; pfam04972 716541002816 BON domain; Region: BON; pfam04972 716541002817 Small integral membrane protein [Function unknown]; Region: COG5487 716541002818 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 716541002819 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 716541002820 active site 716541002821 nucleophile elbow; other site 716541002822 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 716541002823 active site 716541002824 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 716541002825 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 716541002826 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 716541002827 hypothetical protein; Provisional; Region: PRK10977 716541002828 Pyruvate formate lyase; Region: PFL; pfam02901 716541002829 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 716541002830 intersubunit interface [polypeptide binding]; other site 716541002831 active site 716541002832 catalytic residue [active] 716541002833 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 716541002834 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 716541002835 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 716541002836 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 716541002837 phosphopentomutase; Provisional; Region: PRK05362 716541002838 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 716541002839 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 716541002840 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 716541002841 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 716541002842 hypothetical protein; Provisional; Region: PRK11246 716541002843 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 716541002844 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 716541002845 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541002846 motif II; other site 716541002847 DNA repair protein RadA; Region: sms; TIGR00416 716541002848 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 716541002849 Walker A motif/ATP binding site; other site 716541002850 ATP binding site [chemical binding]; other site 716541002851 Walker B motif; other site 716541002852 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 716541002853 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541002854 non-specific DNA binding site [nucleotide binding]; other site 716541002855 salt bridge; other site 716541002856 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 716541002857 sequence-specific DNA binding site [nucleotide binding]; other site 716541002858 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 716541002859 active site 716541002860 (T/H)XGH motif; other site 716541002861 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 716541002862 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 716541002863 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 716541002864 putative NAD(P) binding site [chemical binding]; other site 716541002865 dimer interface [polypeptide binding]; other site 716541002866 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541002867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541002868 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 716541002869 putative effector binding pocket; other site 716541002870 dimerization interface [polypeptide binding]; other site 716541002871 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 716541002872 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716541002873 ABC transporter; Region: ABC_tran_2; pfam12848 716541002874 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716541002875 lytic murein transglycosylase; Provisional; Region: PRK11619 716541002876 Soluble lytic murein transglycosylase L domain; Region: SLT_L; pfam14718 716541002877 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716541002878 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716541002879 catalytic residue [active] 716541002880 Trp operon repressor; Provisional; Region: PRK01381 716541002881 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 716541002882 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 716541002883 catalytic core [active] 716541002884 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 716541002885 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541002886 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541002887 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 716541002888 hypothetical protein; Provisional; Region: PRK10756 716541002889 two-component response regulator; Provisional; Region: PRK11173 716541002890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541002891 active site 716541002892 phosphorylation site [posttranslational modification] 716541002893 intermolecular recognition site; other site 716541002894 dimerization interface [polypeptide binding]; other site 716541002895 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541002896 DNA binding site [nucleotide binding] 716541002897 putative RNA methyltransferase; Provisional; Region: PRK10433 716541002898 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 716541002899 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 716541002900 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 716541002901 putative catalytic residues [active] 716541002902 putative nucleotide binding site [chemical binding]; other site 716541002903 putative aspartate binding site [chemical binding]; other site 716541002904 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 716541002905 dimer interface [polypeptide binding]; other site 716541002906 putative threonine allosteric regulatory site; other site 716541002907 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 716541002908 putative threonine allosteric regulatory site; other site 716541002909 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 716541002910 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 716541002911 homoserine kinase; Provisional; Region: PRK01212 716541002912 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 716541002913 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 716541002914 threonine synthase; Validated; Region: PRK09225 716541002915 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 716541002916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541002917 catalytic residue [active] 716541002918 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 716541002919 hypothetical protein; Validated; Region: PRK02101 716541002920 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 716541002921 transaldolase-like protein; Provisional; Region: PTZ00411 716541002922 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 716541002923 active site 716541002924 dimer interface [polypeptide binding]; other site 716541002925 catalytic residue [active] 716541002926 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 716541002927 MPT binding site; other site 716541002928 trimer interface [polypeptide binding]; other site 716541002929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541002930 metabolite-proton symporter; Region: 2A0106; TIGR00883 716541002931 putative substrate translocation pore; other site 716541002932 hypothetical protein; Provisional; Region: PRK10659 716541002933 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 716541002934 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 716541002935 nucleotide binding site [chemical binding]; other site 716541002936 chaperone protein DnaJ; Provisional; Region: PRK10767 716541002937 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 716541002938 HSP70 interaction site [polypeptide binding]; other site 716541002939 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 716541002940 substrate binding site [polypeptide binding]; other site 716541002941 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 716541002942 Zn binding sites [ion binding]; other site 716541002943 dimer interface [polypeptide binding]; other site 716541002944 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 716541002945 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 716541002946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541002947 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 716541002948 putative dimerization interface [polypeptide binding]; other site 716541002949 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 716541002950 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 716541002951 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 716541002952 active site 716541002953 Riboflavin kinase; Region: Flavokinase; smart00904 716541002954 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 716541002955 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 716541002956 active site 716541002957 HIGH motif; other site 716541002958 KMSKS motif; other site 716541002959 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 716541002960 tRNA binding surface [nucleotide binding]; other site 716541002961 anticodon binding site; other site 716541002962 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 716541002963 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 716541002964 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 716541002965 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 716541002966 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 716541002967 Fe-S cluster binding site [ion binding]; other site 716541002968 substrate binding site [chemical binding]; other site 716541002969 catalytic site [active] 716541002970 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 716541002971 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 716541002972 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 716541002973 Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarA; COG0505 716541002974 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 716541002975 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 716541002976 catalytic site [active] 716541002977 subunit interface [polypeptide binding]; other site 716541002978 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 716541002979 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 716541002980 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 716541002981 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 716541002982 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 716541002983 ATP-grasp domain; Region: ATP-grasp_4; cl17255 716541002984 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 716541002985 IMP binding site; other site 716541002986 dimer interface [polypeptide binding]; other site 716541002987 interdomain contacts; other site 716541002988 partial ornithine binding site; other site 716541002989 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 716541002990 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 716541002991 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 716541002992 Autotransporter beta-domain; Region: Autotransporter; smart00869 716541002993 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 716541002994 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 716541002995 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 716541002996 TrkA-N domain; Region: TrkA_N; pfam02254 716541002997 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 716541002998 folate binding site [chemical binding]; other site 716541002999 NADP+ binding site [chemical binding]; other site 716541003000 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 716541003001 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 716541003002 active site 716541003003 metal binding site [ion binding]; metal-binding site 716541003004 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 716541003005 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 716541003006 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 716541003007 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 716541003008 SurA N-terminal domain; Region: SurA_N; pfam09312 716541003009 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 716541003010 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 716541003011 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 716541003012 OstA-like protein; Region: OstA; pfam03968 716541003013 Organic solvent tolerance protein; Region: OstA_C; pfam04453 716541003014 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 716541003015 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 716541003016 putative metal binding site [ion binding]; other site 716541003017 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 716541003018 HSP70 interaction site [polypeptide binding]; other site 716541003019 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 716541003020 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 716541003021 active site 716541003022 ATP-dependent helicase HepA; Validated; Region: PRK04914 716541003023 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716541003024 ATP binding site [chemical binding]; other site 716541003025 putative Mg++ binding site [ion binding]; other site 716541003026 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716541003027 nucleotide binding region [chemical binding]; other site 716541003028 ATP-binding site [chemical binding]; other site 716541003029 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 716541003030 DNA polymerase II; Reviewed; Region: PRK05762 716541003031 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 716541003032 active site 716541003033 catalytic site [active] 716541003034 substrate binding site [chemical binding]; other site 716541003035 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 716541003036 active site 716541003037 metal-binding site 716541003038 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 716541003039 intersubunit interface [polypeptide binding]; other site 716541003040 active site 716541003041 Zn2+ binding site [ion binding]; other site 716541003042 L-arabinose isomerase; Provisional; Region: PRK02929 716541003043 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 716541003044 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 716541003045 trimer interface [polypeptide binding]; other site 716541003046 putative substrate binding site [chemical binding]; other site 716541003047 putative metal binding site [ion binding]; other site 716541003048 ribulokinase; Provisional; Region: PRK04123 716541003049 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 716541003050 N- and C-terminal domain interface [polypeptide binding]; other site 716541003051 active site 716541003052 MgATP binding site [chemical binding]; other site 716541003053 catalytic site [active] 716541003054 metal binding site [ion binding]; metal-binding site 716541003055 carbohydrate binding site [chemical binding]; other site 716541003056 homodimer interface [polypeptide binding]; other site 716541003057 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 716541003058 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 716541003059 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541003060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541003061 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 716541003062 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 716541003063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541003064 Walker A/P-loop; other site 716541003065 ATP binding site [chemical binding]; other site 716541003066 Q-loop/lid; other site 716541003067 ABC transporter signature motif; other site 716541003068 Walker B; other site 716541003069 D-loop; other site 716541003070 H-loop/switch region; other site 716541003071 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 716541003072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541003073 dimer interface [polypeptide binding]; other site 716541003074 conserved gate region; other site 716541003075 putative PBP binding loops; other site 716541003076 ABC-ATPase subunit interface; other site 716541003077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541003078 dimer interface [polypeptide binding]; other site 716541003079 conserved gate region; other site 716541003080 putative PBP binding loops; other site 716541003081 ABC-ATPase subunit interface; other site 716541003082 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 716541003083 transcriptional regulator SgrR; Provisional; Region: PRK13626 716541003084 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 716541003085 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 716541003086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541003087 sugar efflux transporter; Region: 2A0120; TIGR00899 716541003088 putative substrate translocation pore; other site 716541003089 Hok/gef family; Region: HOK_GEF; cl11494 716541003090 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 716541003091 substrate binding site [chemical binding]; other site 716541003092 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 716541003093 substrate binding site [chemical binding]; other site 716541003094 ligand binding site [chemical binding]; other site 716541003095 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 716541003096 2-isopropylmalate synthase; Validated; Region: PRK00915 716541003097 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 716541003098 active site 716541003099 catalytic residues [active] 716541003100 metal binding site [ion binding]; metal-binding site 716541003101 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 716541003102 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 716541003103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541003104 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 716541003105 putative substrate binding pocket [chemical binding]; other site 716541003106 putative dimerization interface [polypeptide binding]; other site 716541003107 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 716541003108 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 716541003109 PYR/PP interface [polypeptide binding]; other site 716541003110 dimer interface [polypeptide binding]; other site 716541003111 TPP binding site [chemical binding]; other site 716541003112 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 716541003113 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 716541003114 TPP-binding site [chemical binding]; other site 716541003115 dimer interface [polypeptide binding]; other site 716541003116 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 716541003117 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 716541003118 putative valine binding site [chemical binding]; other site 716541003119 dimer interface [polypeptide binding]; other site 716541003120 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 716541003121 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 716541003122 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541003123 DNA binding site [nucleotide binding] 716541003124 domain linker motif; other site 716541003125 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 716541003126 dimerization interface [polypeptide binding]; other site 716541003127 ligand binding site [chemical binding]; other site 716541003128 cell division protein MraZ; Reviewed; Region: PRK00326 716541003129 MraZ protein; Region: MraZ; pfam02381 716541003130 MraZ protein; Region: MraZ; pfam02381 716541003131 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 716541003132 cell division protein FtsL; Provisional; Region: PRK10772 716541003133 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 716541003134 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 716541003135 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 716541003136 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 716541003137 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 716541003138 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 716541003139 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 716541003140 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 716541003141 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 716541003142 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 716541003143 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 716541003144 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 716541003145 Mg++ binding site [ion binding]; other site 716541003146 putative catalytic motif [active] 716541003147 putative substrate binding site [chemical binding]; other site 716541003148 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 716541003149 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 716541003150 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 716541003151 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 716541003152 cell division protein FtsW; Provisional; Region: PRK10774 716541003153 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 716541003154 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 716541003155 active site 716541003156 homodimer interface [polypeptide binding]; other site 716541003157 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 716541003158 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 716541003159 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 716541003160 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 716541003161 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 716541003162 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 716541003163 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 716541003164 cell division protein FtsQ; Provisional; Region: PRK10775 716541003165 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 716541003166 Cell division protein FtsQ; Region: FtsQ; pfam03799 716541003167 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 716541003168 Cell division protein FtsA; Region: FtsA; pfam14450 716541003169 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 716541003170 Cell division protein FtsA; Region: FtsA; pfam14450 716541003171 cell division protein FtsZ; Validated; Region: PRK09330 716541003172 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 716541003173 nucleotide binding site [chemical binding]; other site 716541003174 SulA interaction site; other site 716541003175 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 716541003176 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 716541003177 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 716541003178 SecA regulator SecM; Provisional; Region: PRK02943 716541003179 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 716541003180 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 716541003181 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 716541003182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716541003183 nucleotide binding region [chemical binding]; other site 716541003184 ATP-binding site [chemical binding]; other site 716541003185 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 716541003186 SEC-C motif; Region: SEC-C; pfam02810 716541003187 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 716541003188 active site 716541003189 8-oxo-dGMP binding site [chemical binding]; other site 716541003190 nudix motif; other site 716541003191 metal binding site [ion binding]; metal-binding site 716541003192 DNA gyrase inhibitor; Reviewed; Region: PRK00418 716541003193 hypothetical protein; Provisional; Region: PRK05287 716541003194 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 716541003195 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 716541003196 CoA-binding site [chemical binding]; other site 716541003197 ATP-binding [chemical binding]; other site 716541003198 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 716541003199 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 716541003200 active site 716541003201 type IV pilin biogenesis protein; Provisional; Region: PRK10573 716541003202 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 716541003203 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 716541003204 hypothetical protein; Provisional; Region: PRK10436 716541003205 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 716541003206 Walker A motif; other site 716541003207 ATP binding site [chemical binding]; other site 716541003208 Walker B motif; other site 716541003209 putative major pilin subunit; Provisional; Region: PRK10574 716541003210 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 716541003211 Pilin (bacterial filament); Region: Pilin; pfam00114 716541003212 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 716541003213 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 716541003214 dimerization interface [polypeptide binding]; other site 716541003215 active site 716541003216 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 716541003217 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 716541003218 amidase catalytic site [active] 716541003219 Zn binding residues [ion binding]; other site 716541003220 substrate binding site [chemical binding]; other site 716541003221 regulatory protein AmpE; Provisional; Region: PRK10987 716541003222 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 716541003223 active site 716541003224 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 716541003225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541003226 putative substrate translocation pore; other site 716541003227 aromatic amino acid transporter; Provisional; Region: PRK10238 716541003228 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 716541003229 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 716541003230 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541003231 DNA-binding site [nucleotide binding]; DNA binding site 716541003232 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 716541003233 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 716541003234 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 716541003235 dimer interface [polypeptide binding]; other site 716541003236 TPP-binding site [chemical binding]; other site 716541003237 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 716541003238 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 716541003239 E3 interaction surface; other site 716541003240 lipoyl attachment site [posttranslational modification]; other site 716541003241 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 716541003242 E3 interaction surface; other site 716541003243 lipoyl attachment site [posttranslational modification]; other site 716541003244 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 716541003245 E3 interaction surface; other site 716541003246 lipoyl attachment site [posttranslational modification]; other site 716541003247 e3 binding domain; Region: E3_binding; pfam02817 716541003248 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 716541003249 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 716541003250 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541003251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716541003252 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 716541003253 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 716541003254 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 716541003255 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 716541003256 Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791 716541003257 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 716541003258 substrate binding site [chemical binding]; other site 716541003259 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 716541003260 substrate binding site [chemical binding]; other site 716541003261 ligand binding site [chemical binding]; other site 716541003262 hypothetical protein; Provisional; Region: PRK05248 716541003263 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 716541003264 catalytic residues [active] 716541003265 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 716541003266 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 716541003267 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 716541003268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 716541003269 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541003270 DNA binding residues [nucleotide binding] 716541003271 dimerization interface [polypeptide binding]; other site 716541003272 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 716541003273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541003274 S-adenosylmethionine binding site [chemical binding]; other site 716541003275 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 716541003276 multicopper oxidase; Provisional; Region: PRK10965 716541003277 The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232 716541003278 Domain 2 interface [polypeptide binding]; other site 716541003279 Domain 3 interface [polypeptide binding]; other site 716541003280 trinuclear Cu binding site [ion binding]; other site 716541003281 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 716541003282 Domain 1 interface [polypeptide binding]; other site 716541003283 Domain 3 interface [polypeptide binding]; other site 716541003284 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 716541003285 Domain 2 interface [polypeptide binding]; other site 716541003286 Domain 1 interface [polypeptide binding]; other site 716541003287 Type 1 (T1) Cu binding site [ion binding]; other site 716541003288 trinuclear Cu binding site [ion binding]; other site 716541003289 Glucose dehydrogenase [Carbohydrate transport and metabolism]; Region: Gcd; COG4993 716541003290 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 716541003291 Trp docking motif [polypeptide binding]; other site 716541003292 putative active site [active] 716541003293 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 716541003294 active site 716541003295 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 716541003296 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 716541003297 active site clefts [active] 716541003298 zinc binding site [ion binding]; other site 716541003299 dimer interface [polypeptide binding]; other site 716541003300 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 716541003301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541003302 Walker A/P-loop; other site 716541003303 ATP binding site [chemical binding]; other site 716541003304 Q-loop/lid; other site 716541003305 ABC transporter signature motif; other site 716541003306 Walker B; other site 716541003307 D-loop; other site 716541003308 H-loop/switch region; other site 716541003309 inner membrane transport permease; Provisional; Region: PRK15066 716541003310 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 716541003311 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 716541003312 active pocket/dimerization site; other site 716541003313 active site 716541003314 phosphorylation site [posttranslational modification] 716541003315 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 716541003316 putative active site [active] 716541003317 putative metal binding site [ion binding]; other site 716541003318 putative fimbrial protein StkG; Provisional; Region: PRK15305 716541003319 putative fimbrial protein StaF; Provisional; Region: PRK15262 716541003320 putative fimbrial protein StaE; Provisional; Region: PRK15263 716541003321 putative fimbrial protein StkD; Provisional; Region: PRK15306 716541003322 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 716541003323 PapC N-terminal domain; Region: PapC_N; pfam13954 716541003324 Outer membrane usher protein; Region: Usher; pfam00577 716541003325 PapC C-terminal domain; Region: PapC_C; pfam13953 716541003326 putative chaperone protein EcpD; Provisional; Region: PRK09926 716541003327 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 716541003328 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 716541003329 major fimbrial protein StkA; Provisional; Region: PRK15307 716541003330 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 716541003331 tetramerization interface [polypeptide binding]; other site 716541003332 active site 716541003333 Pantoate-beta-alanine ligase; Region: PanC; cd00560 716541003334 active site 716541003335 ATP-binding site [chemical binding]; other site 716541003336 pantoate-binding site; other site 716541003337 HXXH motif; other site 716541003338 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 716541003339 oligomerization interface [polypeptide binding]; other site 716541003340 active site 716541003341 metal binding site [ion binding]; metal-binding site 716541003342 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 716541003343 catalytic center binding site [active] 716541003344 ATP binding site [chemical binding]; other site 716541003345 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 716541003346 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 716541003347 active site 716541003348 NTP binding site [chemical binding]; other site 716541003349 metal binding triad [ion binding]; metal-binding site 716541003350 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 716541003351 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 716541003352 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 716541003353 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 716541003354 active site 716541003355 nucleotide binding site [chemical binding]; other site 716541003356 HIGH motif; other site 716541003357 KMSKS motif; other site 716541003358 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 716541003359 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 716541003360 2'-5' RNA ligase; Provisional; Region: PRK15124 716541003361 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 716541003362 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 716541003363 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 716541003364 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716541003365 ATP binding site [chemical binding]; other site 716541003366 putative Mg++ binding site [ion binding]; other site 716541003367 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716541003368 nucleotide binding region [chemical binding]; other site 716541003369 ATP-binding site [chemical binding]; other site 716541003370 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 716541003371 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 716541003372 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 716541003373 Transmembrane domain of transglycosylase PBP1 at N-terminal; Region: PBP1_TM; pfam14812 716541003374 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 716541003375 Transglycosylase; Region: Transgly; pfam00912 716541003376 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 716541003377 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 716541003378 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 716541003379 N-terminal plug; other site 716541003380 ligand-binding site [chemical binding]; other site 716541003381 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 716541003382 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 716541003383 Walker A/P-loop; other site 716541003384 ATP binding site [chemical binding]; other site 716541003385 Q-loop/lid; other site 716541003386 ABC transporter signature motif; other site 716541003387 Walker B; other site 716541003388 D-loop; other site 716541003389 H-loop/switch region; other site 716541003390 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 716541003391 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 716541003392 siderophore binding site; other site 716541003393 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 716541003394 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716541003395 ABC-ATPase subunit interface; other site 716541003396 dimer interface [polypeptide binding]; other site 716541003397 putative PBP binding regions; other site 716541003398 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716541003399 ABC-ATPase subunit interface; other site 716541003400 dimer interface [polypeptide binding]; other site 716541003401 putative PBP binding regions; other site 716541003402 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 716541003403 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 716541003404 inhibitor-cofactor binding pocket; inhibition site 716541003405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541003406 catalytic residue [active] 716541003407 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 716541003408 Cl- selectivity filter; other site 716541003409 Cl- binding residues [ion binding]; other site 716541003410 pore gating glutamate residue; other site 716541003411 dimer interface [polypeptide binding]; other site 716541003412 H+/Cl- coupling transport residue; other site 716541003413 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 716541003414 hypothetical protein; Provisional; Region: PRK10578 716541003415 UPF0126 domain; Region: UPF0126; pfam03458 716541003416 UPF0126 domain; Region: UPF0126; pfam03458 716541003417 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 716541003418 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 716541003419 cobalamin binding residues [chemical binding]; other site 716541003420 putative BtuC binding residues; other site 716541003421 dimer interface [polypeptide binding]; other site 716541003422 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 716541003423 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 716541003424 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 716541003425 Zn2+ binding site [ion binding]; other site 716541003426 Mg2+ binding site [ion binding]; other site 716541003427 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 716541003428 serine endoprotease; Provisional; Region: PRK10942 716541003429 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 716541003430 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 716541003431 protein binding site [polypeptide binding]; other site 716541003432 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 716541003433 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 716541003434 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 716541003435 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 716541003436 hypothetical protein; Provisional; Region: PRK13677 716541003437 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 716541003438 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805 716541003439 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 716541003440 trimer interface [polypeptide binding]; other site 716541003441 active site 716541003442 substrate binding site [chemical binding]; other site 716541003443 CoA binding site [chemical binding]; other site 716541003444 PII uridylyl-transferase; Provisional; Region: PRK05007 716541003445 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 716541003446 metal binding triad; other site 716541003447 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 716541003448 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 716541003449 Zn2+ binding site [ion binding]; other site 716541003450 Mg2+ binding site [ion binding]; other site 716541003451 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 716541003452 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 716541003453 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 716541003454 active site 716541003455 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 716541003456 rRNA interaction site [nucleotide binding]; other site 716541003457 S8 interaction site; other site 716541003458 putative laminin-1 binding site; other site 716541003459 elongation factor Ts; Provisional; Region: tsf; PRK09377 716541003460 UBA/TS-N domain; Region: UBA; pfam00627 716541003461 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 716541003462 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 716541003463 putative nucleotide binding site [chemical binding]; other site 716541003464 uridine monophosphate binding site [chemical binding]; other site 716541003465 homohexameric interface [polypeptide binding]; other site 716541003466 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 716541003467 hinge region; other site 716541003468 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 716541003469 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 716541003470 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 716541003471 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 716541003472 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 716541003473 active site 716541003474 dimer interface [polypeptide binding]; other site 716541003475 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 716541003476 zinc metallopeptidase RseP; Provisional; Region: PRK10779 716541003477 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 716541003478 active site 716541003479 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 716541003480 protein binding site [polypeptide binding]; other site 716541003481 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 716541003482 protein binding site [polypeptide binding]; other site 716541003483 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 716541003484 putative substrate binding region [chemical binding]; other site 716541003485 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 716541003486 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 716541003487 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 716541003488 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 716541003489 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 716541003490 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 716541003491 Surface antigen; Region: Bac_surface_Ag; pfam01103 716541003492 periplasmic chaperone; Provisional; Region: PRK10780 716541003493 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 716541003494 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 716541003495 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 716541003496 trimer interface [polypeptide binding]; other site 716541003497 active site 716541003498 UDP-GlcNAc binding site [chemical binding]; other site 716541003499 lipid binding site [chemical binding]; lipid-binding site 716541003500 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 716541003501 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 716541003502 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 716541003503 active site 716541003504 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 716541003505 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 716541003506 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 716541003507 RNA/DNA hybrid binding site [nucleotide binding]; other site 716541003508 active site 716541003509 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 716541003510 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 716541003511 putative active site [active] 716541003512 putative PHP Thumb interface [polypeptide binding]; other site 716541003513 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 716541003514 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 716541003515 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 716541003516 generic binding surface II; other site 716541003517 generic binding surface I; other site 716541003518 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 716541003519 lysine decarboxylase LdcC; Provisional; Region: PRK15399 716541003520 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 716541003521 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 716541003522 homodimer interface [polypeptide binding]; other site 716541003523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541003524 catalytic residue [active] 716541003525 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 716541003526 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 716541003527 putative metal binding site [ion binding]; other site 716541003528 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 716541003529 TilS substrate binding domain; Region: TilS; pfam09179 716541003530 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 716541003531 Rho-binding antiterminator; Provisional; Region: PRK11625 716541003532 hypothetical protein; Provisional; Region: PRK04964 716541003533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 716541003534 hypothetical protein; Provisional; Region: PRK09256 716541003535 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 716541003536 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 716541003537 NlpE N-terminal domain; Region: NlpE; cl19736 716541003538 prolyl-tRNA synthetase; Provisional; Region: PRK09194 716541003539 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 716541003540 dimer interface [polypeptide binding]; other site 716541003541 motif 1; other site 716541003542 active site 716541003543 motif 2; other site 716541003544 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 716541003545 putative deacylase active site [active] 716541003546 motif 3; other site 716541003547 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 716541003548 anticodon binding site; other site 716541003549 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 716541003550 homodimer interaction site [polypeptide binding]; other site 716541003551 cofactor binding site; other site 716541003552 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 716541003553 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 716541003554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541003555 dimer interface [polypeptide binding]; other site 716541003556 conserved gate region; other site 716541003557 ABC-ATPase subunit interface; other site 716541003558 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 716541003559 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 716541003560 Walker A/P-loop; other site 716541003561 ATP binding site [chemical binding]; other site 716541003562 Q-loop/lid; other site 716541003563 ABC transporter signature motif; other site 716541003564 Walker B; other site 716541003565 D-loop; other site 716541003566 H-loop/switch region; other site 716541003567 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 716541003568 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 716541003569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541003570 active site 716541003571 motif I; other site 716541003572 motif II; other site 716541003573 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 716541003574 active site 716541003575 catalytic tetrad [active] 716541003576 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541003577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541003578 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 716541003579 putative effector binding pocket; other site 716541003580 dimerization interface [polypeptide binding]; other site 716541003581 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 716541003582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541003583 putative substrate translocation pore; other site 716541003584 hypothetical protein; Provisional; Region: PRK05421 716541003585 putative catalytic site [active] 716541003586 putative metal binding site [ion binding]; other site 716541003587 putative phosphate binding site [ion binding]; other site 716541003588 putative catalytic site [active] 716541003589 putative phosphate binding site [ion binding]; other site 716541003590 putative metal binding site [ion binding]; other site 716541003591 Methyltransferase domain; Region: Methyltransf_31; pfam13847 716541003592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541003593 S-adenosylmethionine binding site [chemical binding]; other site 716541003594 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 716541003595 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716541003596 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716541003597 catalytic residue [active] 716541003598 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 716541003599 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 716541003600 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 716541003601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541003602 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 716541003603 RNA/DNA hybrid binding site [nucleotide binding]; other site 716541003604 active site 716541003605 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 716541003606 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 716541003607 active site 716541003608 catalytic site [active] 716541003609 substrate binding site [chemical binding]; other site 716541003610 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003611 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003612 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003613 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 716541003614 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003615 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003616 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003617 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003618 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003619 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 716541003620 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003621 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003622 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 716541003623 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003624 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003625 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 716541003626 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003627 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003628 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003629 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 716541003630 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003631 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003632 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 716541003633 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003634 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003635 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003636 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003637 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003638 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003639 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 716541003640 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003641 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003642 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003643 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003644 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541003645 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 716541003646 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 716541003647 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 716541003648 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 716541003649 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 716541003650 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 716541003651 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 716541003652 ligand binding site [chemical binding]; other site 716541003653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 716541003654 DNA binding residues [nucleotide binding] 716541003655 polysaccharide export protein Wza; Provisional; Region: PRK15078 716541003656 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 716541003657 SLBB domain; Region: SLBB; pfam10531 716541003658 Low molecular weight phosphatase family; Region: LMWPc; cd00115 716541003659 active site 716541003660 tyrosine kinase; Provisional; Region: PRK11519 716541003661 Chain length determinant protein; Region: Wzz; pfam02706 716541003662 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 716541003663 AAA domain; Region: AAA_31; pfam13614 716541003664 haemagglutination activity domain; Region: Haemagg_act; pfam05860 716541003665 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541003666 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541003667 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 716541003668 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 716541003669 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 716541003670 Aminomethyltransferase folate-binding domain; Region: GCV_T; cl01893 716541003671 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 716541003672 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 716541003673 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 716541003674 dimer interface [polypeptide binding]; other site 716541003675 active site 716541003676 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 716541003677 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 716541003678 active site 716541003679 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 716541003680 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 716541003681 active site 716541003682 DTW domain; Region: DTW; cl01221 716541003683 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 716541003684 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 716541003685 Walker A/P-loop; other site 716541003686 ATP binding site [chemical binding]; other site 716541003687 Q-loop/lid; other site 716541003688 ABC transporter signature motif; other site 716541003689 Walker B; other site 716541003690 D-loop; other site 716541003691 H-loop/switch region; other site 716541003692 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 716541003693 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 716541003694 FtsX-like permease family; Region: FtsX; pfam02687 716541003695 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 716541003696 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 716541003697 Outer membrane efflux protein; Region: OEP; pfam02321 716541003698 Outer membrane efflux protein; Region: OEP; pfam02321 716541003699 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 716541003700 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541003701 Nucleoporin complex subunit 54; Region: Nup54; pfam13874 716541003702 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541003703 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 716541003704 putative active site [active] 716541003705 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 716541003706 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 716541003707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541003708 Walker A/P-loop; other site 716541003709 ATP binding site [chemical binding]; other site 716541003710 Q-loop/lid; other site 716541003711 ABC transporter signature motif; other site 716541003712 Walker B; other site 716541003713 D-loop; other site 716541003714 H-loop/switch region; other site 716541003715 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 716541003716 Transcriptional regulators [Transcription]; Region: FadR; COG2186 716541003717 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541003718 DNA-binding site [nucleotide binding]; DNA binding site 716541003719 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 716541003720 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 716541003721 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716541003722 Walker A/P-loop; other site 716541003723 ATP binding site [chemical binding]; other site 716541003724 Q-loop/lid; other site 716541003725 ABC transporter signature motif; other site 716541003726 Walker B; other site 716541003727 D-loop; other site 716541003728 H-loop/switch region; other site 716541003729 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 716541003730 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 716541003731 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716541003732 Walker A/P-loop; other site 716541003733 ATP binding site [chemical binding]; other site 716541003734 Q-loop/lid; other site 716541003735 ABC transporter signature motif; other site 716541003736 Walker B; other site 716541003737 D-loop; other site 716541003738 H-loop/switch region; other site 716541003739 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 716541003740 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 716541003741 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 716541003742 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 716541003743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541003744 dimer interface [polypeptide binding]; other site 716541003745 conserved gate region; other site 716541003746 putative PBP binding loops; other site 716541003747 ABC-ATPase subunit interface; other site 716541003748 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 716541003749 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 716541003750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541003751 dimer interface [polypeptide binding]; other site 716541003752 conserved gate region; other site 716541003753 putative PBP binding loops; other site 716541003754 ABC-ATPase subunit interface; other site 716541003755 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 716541003756 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 716541003757 putative active site [active] 716541003758 catalytic triad [active] 716541003759 multimer interface [polypeptide binding]; other site 716541003760 dimer interface [polypeptide binding]; other site 716541003761 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 716541003762 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 716541003763 active site 716541003764 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 716541003765 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 716541003766 dimer interface [polypeptide binding]; other site 716541003767 active site 716541003768 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 716541003769 putative active site [active] 716541003770 Glutamine amidotransferases class-II; Region: GATase_2; pfam00310 716541003771 putative dimer interface [polypeptide binding]; other site 716541003772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 716541003773 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 716541003774 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 716541003775 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 716541003776 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 716541003777 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 716541003778 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 716541003779 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 716541003780 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 716541003781 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 716541003782 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 716541003783 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 716541003784 FAD binding pocket [chemical binding]; other site 716541003785 FAD binding motif [chemical binding]; other site 716541003786 phosphate binding motif [ion binding]; other site 716541003787 beta-alpha-beta structure motif; other site 716541003788 NAD binding pocket [chemical binding]; other site 716541003789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 716541003790 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 716541003791 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 716541003792 active site 716541003793 catalytic site [active] 716541003794 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 716541003795 active site 716541003796 DNA polymerase IV; Validated; Region: PRK02406 716541003797 DNA binding site [nucleotide binding] 716541003798 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541003799 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 716541003800 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 716541003801 metal binding site [ion binding]; metal-binding site 716541003802 dimer interface [polypeptide binding]; other site 716541003803 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 716541003804 active site 716541003805 Putative lysophospholipase; Region: Hydrolase_4; cl19140 716541003806 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 716541003807 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 716541003808 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541003809 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541003810 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 716541003811 trimer interface [polypeptide binding]; other site 716541003812 eyelet of channel; other site 716541003813 gamma-glutamyl kinase; Provisional; Region: PRK05429 716541003814 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 716541003815 nucleotide binding site [chemical binding]; other site 716541003816 homotetrameric interface [polypeptide binding]; other site 716541003817 putative phosphate binding site [ion binding]; other site 716541003818 putative allosteric binding site; other site 716541003819 PUA domain; Region: PUA; pfam01472 716541003820 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 716541003821 putative catalytic cysteine [active] 716541003822 integrase; Provisional; Region: PRK09692 716541003823 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 716541003824 active site 716541003825 Int/Topo IB signature motif; other site 716541003826 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 716541003827 Ash protein family; Region: Phage_ASH; pfam10554 716541003828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 716541003829 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 716541003830 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 716541003831 active site 716541003832 metal binding site [ion binding]; metal-binding site 716541003833 interdomain interaction site; other site 716541003834 Domain of unknown function (DUF927); Region: DUF927; pfam06048 716541003835 HNH endonuclease; Region: HNH_2; pfam13391 716541003836 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 716541003837 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 716541003838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541003839 S-adenosylmethionine binding site [chemical binding]; other site 716541003840 hypothetical protein; Provisional; Region: PRK13687 716541003841 Major royal jelly protein; Region: MRJP; pfam03022 716541003842 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 716541003843 classical (c) SDRs; Region: SDR_c; cd05233 716541003844 NAD(P) binding site [chemical binding]; other site 716541003845 active site 716541003846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541003847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541003848 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 716541003849 putative effector binding pocket; other site 716541003850 dimerization interface [polypeptide binding]; other site 716541003851 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541003852 dimerization interface [polypeptide binding]; other site 716541003853 GAF domain; Region: GAF_3; pfam13492 716541003854 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541003855 metal binding site [ion binding]; metal-binding site 716541003856 active site 716541003857 I-site; other site 716541003858 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 716541003859 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 716541003860 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 716541003861 metal binding site [ion binding]; metal-binding site 716541003862 dimer interface [polypeptide binding]; other site 716541003863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541003864 D-galactonate transporter; Region: 2A0114; TIGR00893 716541003865 putative substrate translocation pore; other site 716541003866 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 716541003867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541003868 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541003869 dimerization interface [polypeptide binding]; other site 716541003870 S-methylmethionine transporter; Provisional; Region: PRK11387 716541003871 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 716541003872 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 716541003873 Fimbrial protein; Region: Fimbrial; cl01416 716541003874 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 716541003875 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 716541003876 PapC N-terminal domain; Region: PapC_N; pfam13954 716541003877 Outer membrane usher protein; Region: Usher; pfam00577 716541003878 PapC C-terminal domain; Region: PapC_C; pfam13953 716541003879 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 716541003880 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 716541003881 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 716541003882 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 716541003883 Fimbrial protein; Region: Fimbrial; pfam00419 716541003884 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541003885 Transposase; Region: HTH_Tnp_1; cl17663 716541003886 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541003887 IS2 transposase TnpB; Reviewed; Region: PRK09409 716541003888 HTH-like domain; Region: HTH_21; pfam13276 716541003889 Integrase core domain; Region: rve; pfam00665 716541003890 Integrase core domain; Region: rve_3; pfam13683 716541003891 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 716541003892 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541003893 Walker A/P-loop; other site 716541003894 ATP binding site [chemical binding]; other site 716541003895 Q-loop/lid; other site 716541003896 ABC transporter signature motif; other site 716541003897 Walker B; other site 716541003898 D-loop; other site 716541003899 H-loop/switch region; other site 716541003900 TOBE domain; Region: TOBE_2; pfam08402 716541003901 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 716541003902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541003903 dimer interface [polypeptide binding]; other site 716541003904 conserved gate region; other site 716541003905 putative PBP binding loops; other site 716541003906 ABC-ATPase subunit interface; other site 716541003907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541003908 dimer interface [polypeptide binding]; other site 716541003909 conserved gate region; other site 716541003910 putative PBP binding loops; other site 716541003911 ABC-ATPase subunit interface; other site 716541003912 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 716541003913 regulatory protein UhpC; Provisional; Region: PRK11663 716541003914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541003915 putative substrate translocation pore; other site 716541003916 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 716541003917 MASE1; Region: MASE1; pfam05231 716541003918 Histidine kinase; Region: HisKA_3; pfam07730 716541003919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541003920 ATP binding site [chemical binding]; other site 716541003921 Mg2+ binding site [ion binding]; other site 716541003922 G-X-G motif; other site 716541003923 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 716541003924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541003925 active site 716541003926 phosphorylation site [posttranslational modification] 716541003927 intermolecular recognition site; other site 716541003928 dimerization interface [polypeptide binding]; other site 716541003929 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541003930 DNA binding residues [nucleotide binding] 716541003931 dimerization interface [polypeptide binding]; other site 716541003932 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 716541003933 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541003934 substrate binding pocket [chemical binding]; other site 716541003935 membrane-bound complex binding site; other site 716541003936 hinge residues; other site 716541003937 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 716541003938 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 716541003939 Walker A/P-loop; other site 716541003940 ATP binding site [chemical binding]; other site 716541003941 Q-loop/lid; other site 716541003942 ABC transporter signature motif; other site 716541003943 Walker B; other site 716541003944 D-loop; other site 716541003945 H-loop/switch region; other site 716541003946 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 716541003947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541003948 dimer interface [polypeptide binding]; other site 716541003949 conserved gate region; other site 716541003950 putative PBP binding loops; other site 716541003951 ABC-ATPase subunit interface; other site 716541003952 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 716541003953 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 716541003954 active site 716541003955 iron coordination sites [ion binding]; other site 716541003956 substrate binding pocket [chemical binding]; other site 716541003957 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 716541003958 putative acyl-acceptor binding pocket; other site 716541003959 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 716541003960 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 716541003961 dimer interface [polypeptide binding]; other site 716541003962 active site 716541003963 Schiff base residues; other site 716541003964 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 716541003965 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 716541003966 Autotransporter beta-domain; Region: Autotransporter; pfam03797 716541003967 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 716541003968 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 716541003969 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 716541003970 catalytic triad [active] 716541003971 conserved cis-peptide bond; other site 716541003972 microcin B17 transporter; Reviewed; Region: PRK11098 716541003973 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 716541003974 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 716541003975 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 716541003976 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 716541003977 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 716541003978 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 716541003979 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 716541003980 drug efflux system protein MdtG; Provisional; Region: PRK09874 716541003981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541003982 putative substrate translocation pore; other site 716541003983 anti-RssB factor; Provisional; Region: PRK10244 716541003984 hypothetical protein; Provisional; Region: PRK11505 716541003985 psiF repeat; Region: PsiF_repeat; pfam07769 716541003986 psiF repeat; Region: PsiF_repeat; pfam07769 716541003987 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 716541003988 MASE2 domain; Region: MASE2; pfam05230 716541003989 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541003990 metal binding site [ion binding]; metal-binding site 716541003991 active site 716541003992 I-site; other site 716541003993 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 716541003994 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 716541003995 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 716541003996 hypothetical protein; Validated; Region: PRK00124 716541003997 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 716541003998 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 716541003999 ADP binding site [chemical binding]; other site 716541004000 magnesium binding site [ion binding]; other site 716541004001 putative shikimate binding site; other site 716541004002 hypothetical protein; Provisional; Region: PRK10380 716541004003 hypothetical protein; Provisional; Region: PRK10481 716541004004 hypothetical protein; Provisional; Region: PRK10579 716541004005 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 716541004006 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 716541004007 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 716541004008 nucleotide binding site [chemical binding]; other site 716541004009 exonuclease subunit SbcC; Provisional; Region: PRK10246 716541004010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541004011 Walker A/P-loop; other site 716541004012 ATP binding site [chemical binding]; other site 716541004013 Q-loop/lid; other site 716541004014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541004015 ABC transporter signature motif; other site 716541004016 Walker B; other site 716541004017 D-loop; other site 716541004018 H-loop/switch region; other site 716541004019 exonuclease subunit SbcD; Provisional; Region: PRK10966 716541004020 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 716541004021 active site 716541004022 metal binding site [ion binding]; metal-binding site 716541004023 DNA binding site [nucleotide binding] 716541004024 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 716541004025 transcriptional regulator PhoB; Provisional; Region: PRK10161 716541004026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541004027 active site 716541004028 phosphorylation site [posttranslational modification] 716541004029 intermolecular recognition site; other site 716541004030 dimerization interface [polypeptide binding]; other site 716541004031 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541004032 DNA binding site [nucleotide binding] 716541004033 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 716541004034 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 716541004035 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716541004036 putative active site [active] 716541004037 heme pocket [chemical binding]; other site 716541004038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541004039 dimer interface [polypeptide binding]; other site 716541004040 phosphorylation site [posttranslational modification] 716541004041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541004042 ATP binding site [chemical binding]; other site 716541004043 Mg2+ binding site [ion binding]; other site 716541004044 G-X-G motif; other site 716541004045 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 716541004046 putative proline-specific permease; Provisional; Region: proY; PRK10580 716541004047 Spore germination protein; Region: Spore_permease; cl17796 716541004048 maltodextrin glucosidase; Provisional; Region: PRK10785 716541004049 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 716541004050 homodimer interface [polypeptide binding]; other site 716541004051 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 716541004052 active site 716541004053 homodimer interface [polypeptide binding]; other site 716541004054 catalytic site [active] 716541004055 peroxidase; Provisional; Region: PRK15000 716541004056 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 716541004057 dimer interface [polypeptide binding]; other site 716541004058 decamer (pentamer of dimers) interface [polypeptide binding]; other site 716541004059 catalytic triad [active] 716541004060 peroxidatic and resolving cysteines [active] 716541004061 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 716541004062 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 716541004063 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 716541004064 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 716541004065 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 716541004066 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 716541004067 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 716541004068 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 716541004069 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 716541004070 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 716541004071 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 716541004072 Protein export membrane protein; Region: SecD_SecF; pfam02355 716541004073 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 716541004074 Predicted transcriptional regulator [Transcription]; Region: COG2378 716541004075 HTH domain; Region: HTH_11; pfam08279 716541004076 WYL domain; Region: WYL; pfam13280 716541004077 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 716541004078 hypothetical protein; Provisional; Region: PRK11530 716541004079 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 716541004080 ATP cone domain; Region: ATP-cone; pfam03477 716541004081 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 716541004082 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 716541004083 catalytic motif [active] 716541004084 Zn binding site [ion binding]; other site 716541004085 RibD C-terminal domain; Region: RibD_C; cl17279 716541004086 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 716541004087 homopentamer interface [polypeptide binding]; other site 716541004088 active site 716541004089 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 716541004090 thiamine monophosphate kinase; Provisional; Region: PRK05731 716541004091 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 716541004092 ATP binding site [chemical binding]; other site 716541004093 dimerization interface [polypeptide binding]; other site 716541004094 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 716541004095 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 716541004096 active site 716541004097 catalytic tetrad [active] 716541004098 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 716541004099 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 716541004100 TPP-binding site; other site 716541004101 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 716541004102 PYR/PP interface [polypeptide binding]; other site 716541004103 dimer interface [polypeptide binding]; other site 716541004104 TPP binding site [chemical binding]; other site 716541004105 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 716541004106 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 716541004107 substrate binding pocket [chemical binding]; other site 716541004108 chain length determination region; other site 716541004109 active site lid residues [active] 716541004110 substrate-Mg2+ binding site; other site 716541004111 catalytic residues [active] 716541004112 aspartate-rich region 1; other site 716541004113 aspartate-rich region 2; other site 716541004114 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 716541004115 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 716541004116 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 716541004117 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 716541004118 Ligand Binding Site [chemical binding]; other site 716541004119 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 716541004120 active site residue [active] 716541004121 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 716541004122 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 716541004123 conserved cys residue [active] 716541004124 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 716541004125 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 716541004126 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 716541004127 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 716541004128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541004129 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716541004130 putative substrate translocation pore; other site 716541004131 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 716541004132 putative active site [active] 716541004133 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 716541004134 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 716541004135 Subunit III/IV interface [polypeptide binding]; other site 716541004136 Subunit I/III interface [polypeptide binding]; other site 716541004137 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 716541004138 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 716541004139 D-pathway; other site 716541004140 Putative ubiquinol binding site [chemical binding]; other site 716541004141 Low-spin heme (heme b) binding site [chemical binding]; other site 716541004142 Putative water exit pathway; other site 716541004143 Binuclear center (heme o3/CuB) [ion binding]; other site 716541004144 K-pathway; other site 716541004145 Putative proton exit pathway; other site 716541004146 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 716541004147 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 716541004148 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 716541004149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541004150 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716541004151 putative substrate translocation pore; other site 716541004152 hypothetical protein; Provisional; Region: PRK11627 716541004153 transcriptional regulator BolA; Provisional; Region: PRK11628 716541004154 trigger factor; Provisional; Region: tig; PRK01490 716541004155 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 716541004156 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 716541004157 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 716541004158 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 716541004159 oligomer interface [polypeptide binding]; other site 716541004160 active site residues [active] 716541004161 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 716541004162 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 716541004163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541004164 Walker A motif; other site 716541004165 ATP binding site [chemical binding]; other site 716541004166 Walker B motif; other site 716541004167 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 716541004168 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 716541004169 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 716541004170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541004171 Walker A motif; other site 716541004172 ATP binding site [chemical binding]; other site 716541004173 Walker B motif; other site 716541004174 arginine finger; other site 716541004175 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 716541004176 histone-like DNA-binding protein HU; Region: HU; cd13831 716541004177 dimer interface [polypeptide binding]; other site 716541004178 DNA binding site [nucleotide binding] 716541004179 periplasmic folding chaperone; Provisional; Region: PRK10788 716541004180 SurA N-terminal domain; Region: SurA_N_3; cl07813 716541004181 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 716541004182 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 716541004183 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 716541004184 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 716541004185 active site 716541004186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541004187 non-specific DNA binding site [nucleotide binding]; other site 716541004188 salt bridge; other site 716541004189 sequence-specific DNA binding site [nucleotide binding]; other site 716541004190 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 716541004191 Ligand Binding Site [chemical binding]; other site 716541004192 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 716541004193 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 716541004194 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 716541004195 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 716541004196 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541004197 active site 716541004198 motif I; other site 716541004199 motif II; other site 716541004200 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 716541004201 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 716541004202 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 716541004203 catalytic residue [active] 716541004204 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 716541004205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716541004206 putative DNA binding site [nucleotide binding]; other site 716541004207 putative Zn2+ binding site [ion binding]; other site 716541004208 AsnC family; Region: AsnC_trans_reg; pfam01037 716541004209 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 716541004210 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 716541004211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541004212 Walker A/P-loop; other site 716541004213 ATP binding site [chemical binding]; other site 716541004214 Q-loop/lid; other site 716541004215 ABC transporter signature motif; other site 716541004216 Walker B; other site 716541004217 D-loop; other site 716541004218 H-loop/switch region; other site 716541004219 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 716541004220 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 716541004221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541004222 Walker A/P-loop; other site 716541004223 ATP binding site [chemical binding]; other site 716541004224 Q-loop/lid; other site 716541004225 ABC transporter signature motif; other site 716541004226 Walker B; other site 716541004227 D-loop; other site 716541004228 H-loop/switch region; other site 716541004229 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 716541004230 ammonium transporter; Provisional; Region: PRK10666 716541004231 acyl-CoA thioesterase II; Provisional; Region: PRK10526 716541004232 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 716541004233 active site 716541004234 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 716541004235 catalytic triad [active] 716541004236 dimer interface [polypeptide binding]; other site 716541004237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 716541004238 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 716541004239 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 716541004240 DNA binding site [nucleotide binding] 716541004241 active site 716541004242 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 716541004243 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541004244 DNA-binding site [nucleotide binding]; DNA binding site 716541004245 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716541004246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541004247 homodimer interface [polypeptide binding]; other site 716541004248 catalytic residue [active] 716541004249 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 716541004250 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 716541004251 lac repressor; Reviewed; Region: lacI; PRK09526 716541004252 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541004253 DNA binding site [nucleotide binding] 716541004254 domain linker motif; other site 716541004255 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 716541004256 ligand binding site [chemical binding]; other site 716541004257 dimerization interface (open form) [polypeptide binding]; other site 716541004258 dimerization interface (closed form) [polypeptide binding]; other site 716541004259 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 716541004260 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 716541004261 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 716541004262 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 716541004263 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 716541004264 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 716541004265 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 716541004266 putative metal binding site [ion binding]; other site 716541004267 putative homodimer interface [polypeptide binding]; other site 716541004268 putative homotetramer interface [polypeptide binding]; other site 716541004269 putative homodimer-homodimer interface [polypeptide binding]; other site 716541004270 putative allosteric switch controlling residues; other site 716541004271 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 716541004272 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 716541004273 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541004274 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 716541004275 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 716541004276 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 716541004277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 716541004278 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 716541004279 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541004280 DNA-binding site [nucleotide binding]; DNA binding site 716541004281 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716541004282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541004283 homodimer interface [polypeptide binding]; other site 716541004284 catalytic residue [active] 716541004285 Inner membrane protein YlaC; Region: YlaC; pfam10777 716541004286 maltose O-acetyltransferase; Provisional; Region: PRK10092 716541004287 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 716541004288 active site 716541004289 substrate binding site [chemical binding]; other site 716541004290 trimer interface [polypeptide binding]; other site 716541004291 CoA binding site [chemical binding]; other site 716541004292 gene expression modulator; Provisional; Region: PRK10945 716541004293 Hha toxicity attenuator; Provisional; Region: PRK10667 716541004294 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 716541004295 MMPL family; Region: MMPL; cl14618 716541004296 MMPL family; Region: MMPL; cl14618 716541004297 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 716541004298 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541004299 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541004300 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 716541004301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716541004302 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 716541004303 hypothetical protein; Provisional; Region: PRK11281 716541004304 FSIP1 family; Region: FSIP1; pfam15554 716541004305 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 716541004306 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 716541004307 Mechanosensitive ion channel; Region: MS_channel; pfam00924 716541004308 hypothetical protein; Provisional; Region: PRK11038 716541004309 primosomal replication protein N''; Provisional; Region: PRK10093 716541004310 hypothetical protein; Provisional; Region: PRK10527 716541004311 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 716541004312 active site 716541004313 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 716541004314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541004315 Walker A motif; other site 716541004316 ATP binding site [chemical binding]; other site 716541004317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 716541004318 Walker B motif; other site 716541004319 arginine finger; other site 716541004320 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 716541004321 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 716541004322 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 716541004323 hypothetical protein; Validated; Region: PRK00153 716541004324 recombination protein RecR; Reviewed; Region: recR; PRK00076 716541004325 RecR protein; Region: RecR; pfam02132 716541004326 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 716541004327 putative active site [active] 716541004328 putative metal-binding site [ion binding]; other site 716541004329 tetramer interface [polypeptide binding]; other site 716541004330 heat shock protein 90; Provisional; Region: PRK05218 716541004331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541004332 ATP binding site [chemical binding]; other site 716541004333 Mg2+ binding site [ion binding]; other site 716541004334 G-X-G motif; other site 716541004335 Hsp90 protein; Region: HSP90; pfam00183 716541004336 adenylate kinase; Reviewed; Region: adk; PRK00279 716541004337 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 716541004338 AMP-binding site [chemical binding]; other site 716541004339 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 716541004340 ferrochelatase; Reviewed; Region: hemH; PRK00035 716541004341 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 716541004342 C-terminal domain interface [polypeptide binding]; other site 716541004343 active site 716541004344 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 716541004345 active site 716541004346 N-terminal domain interface [polypeptide binding]; other site 716541004347 inosine/guanosine kinase; Provisional; Region: PRK15074 716541004348 adenosine kinase; Provisional; Region: PTZ00247 716541004349 substrate binding site [chemical binding]; other site 716541004350 ATP binding site [chemical binding]; other site 716541004351 putative cation:proton antiport protein; Provisional; Region: PRK10669 716541004352 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 716541004353 TrkA-N domain; Region: TrkA_N; pfam02254 716541004354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541004355 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716541004356 putative substrate translocation pore; other site 716541004357 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 716541004358 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 716541004359 active site 716541004360 metal binding site [ion binding]; metal-binding site 716541004361 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 716541004362 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 716541004363 putative deacylase active site [active] 716541004364 TraB family; Region: TraB; cl12050 716541004365 copper exporting ATPase; Provisional; Region: copA; PRK10671 716541004366 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 716541004367 metal-binding site [ion binding] 716541004368 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 716541004369 metal-binding site [ion binding] 716541004370 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 716541004371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541004372 motif II; other site 716541004373 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 716541004374 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 716541004375 DNA binding residues [nucleotide binding] 716541004376 dimer interface [polypeptide binding]; other site 716541004377 copper binding site [ion binding]; other site 716541004378 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 716541004379 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 716541004380 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 716541004381 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 716541004382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541004383 Walker A/P-loop; other site 716541004384 ATP binding site [chemical binding]; other site 716541004385 Q-loop/lid; other site 716541004386 ABC transporter signature motif; other site 716541004387 Walker B; other site 716541004388 D-loop; other site 716541004389 H-loop/switch region; other site 716541004390 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 716541004391 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 716541004392 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 716541004393 Tetratricopeptide repeat; Region: TPR_20; pfam14561 716541004394 short chain dehydrogenase; Validated; Region: PRK06182 716541004395 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 716541004396 NADP binding site [chemical binding]; other site 716541004397 active site 716541004398 steroid binding site; other site 716541004399 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 716541004400 active site 716541004401 catalytic triad [active] 716541004402 oxyanion hole [active] 716541004403 switch loop; other site 716541004404 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 716541004405 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 716541004406 Walker A/P-loop; other site 716541004407 ATP binding site [chemical binding]; other site 716541004408 Q-loop/lid; other site 716541004409 ABC transporter signature motif; other site 716541004410 Walker B; other site 716541004411 D-loop; other site 716541004412 H-loop/switch region; other site 716541004413 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 716541004414 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 716541004415 FtsX-like permease family; Region: FtsX; pfam02687 716541004416 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 716541004417 FtsX-like permease family; Region: FtsX; pfam02687 716541004418 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 716541004419 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 716541004420 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 716541004421 active site residue [active] 716541004422 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 716541004423 ATP-grasp domain; Region: ATP-grasp; pfam02222 716541004424 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 716541004425 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 716541004426 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 716541004427 putative active site [active] 716541004428 putative metal binding site [ion binding]; other site 716541004429 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 716541004430 substrate binding site [chemical binding]; other site 716541004431 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 716541004432 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 716541004433 active site 716541004434 HIGH motif; other site 716541004435 KMSKS motif; other site 716541004436 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 716541004437 tRNA binding surface [nucleotide binding]; other site 716541004438 anticodon binding site; other site 716541004439 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 716541004440 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 716541004441 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541004442 DNA binding site [nucleotide binding] 716541004443 domain linker motif; other site 716541004444 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 716541004445 putative dimerization interface [polypeptide binding]; other site 716541004446 putative ligand binding site [chemical binding]; other site 716541004447 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 716541004448 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 716541004449 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 716541004450 active site turn [active] 716541004451 phosphorylation site [posttranslational modification] 716541004452 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 716541004453 RNA binding surface [nucleotide binding]; other site 716541004454 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 716541004455 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 716541004456 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 716541004457 homodimer interface [polypeptide binding]; other site 716541004458 NADP binding site [chemical binding]; other site 716541004459 substrate binding site [chemical binding]; other site 716541004460 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 716541004461 fimbrial protein FimI; Provisional; Region: PRK15200 716541004462 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 716541004463 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 716541004464 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 716541004465 outer membrane usher protein FimD; Provisional; Region: PRK15198 716541004466 PapC N-terminal domain; Region: PapC_N; pfam13954 716541004467 Outer membrane usher protein; Region: Usher; pfam00577 716541004468 PapC C-terminal domain; Region: PapC_C; pfam13953 716541004469 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 716541004470 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 716541004471 transcriptional regulator FimZ; Provisional; Region: PRK09935 716541004472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541004473 active site 716541004474 phosphorylation site [posttranslational modification] 716541004475 intermolecular recognition site; other site 716541004476 dimerization interface [polypeptide binding]; other site 716541004477 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541004478 DNA binding residues [nucleotide binding] 716541004479 dimerization interface [polypeptide binding]; other site 716541004480 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 716541004481 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 716541004482 DNA binding residues [nucleotide binding] 716541004483 dimerization interface [polypeptide binding]; other site 716541004484 EAL domain; Region: EAL; pfam00563 716541004485 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 716541004486 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 716541004487 Int/Topo IB signature motif; other site 716541004488 Protein of unknown function (DUF550); Region: DUF550; pfam04447 716541004489 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 716541004490 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 716541004491 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 716541004492 DNA binding site [nucleotide binding] 716541004493 MT-A70; Region: MT-A70; cl01947 716541004494 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 716541004495 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 716541004496 RecT family; Region: RecT; cl04285 716541004497 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 716541004498 FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354 716541004499 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541004500 non-specific DNA binding site [nucleotide binding]; other site 716541004501 Predicted transcriptional regulator [Transcription]; Region: COG2932 716541004502 salt bridge; other site 716541004503 sequence-specific DNA binding site [nucleotide binding]; other site 716541004504 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 716541004505 Catalytic site [active] 716541004506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541004507 sequence-specific DNA binding site [nucleotide binding]; other site 716541004508 salt bridge; other site 716541004509 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 716541004510 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 716541004511 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752 716541004512 replicative DNA helicase; Region: DnaB; TIGR00665 716541004513 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 716541004514 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 716541004515 Walker A motif; other site 716541004516 ATP binding site [chemical binding]; other site 716541004517 Walker B motif; other site 716541004518 DNA binding loops [nucleotide binding] 716541004519 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 716541004520 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 716541004521 NinB protein; Region: NinB; pfam05772 716541004522 prophage protein NinE; Provisional; Region: PRK09689 716541004523 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 716541004524 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 716541004525 Lysis protein S; Region: Lysis_S; pfam04971 716541004526 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 716541004527 catalytic residues [active] 716541004528 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 716541004529 KilA-N domain; Region: KilA-N; pfam04383 716541004530 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 716541004531 Phage terminase large subunit; Region: Terminase_3; cl12054 716541004532 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 716541004533 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 716541004534 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 716541004535 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 716541004536 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 716541004537 Phage-related minor tail protein [Function unknown]; Region: COG5281 716541004538 tape measure domain; Region: tape_meas_nterm; TIGR02675 716541004539 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176 716541004540 linker region; other site 716541004541 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 716541004542 Putative phage tail protein; Region: Phage-tail_3; pfam13550 716541004543 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 716541004544 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 716541004545 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 716541004546 Ligand binding site; other site 716541004547 Putative Catalytic site; other site 716541004548 DXD motif; other site 716541004549 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 716541004550 lipoprotein; Provisional; Region: PRK10397 716541004551 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 716541004552 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 716541004553 active site 716541004554 Na/Ca binding site [ion binding]; other site 716541004555 catalytic site [active] 716541004556 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 716541004557 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 716541004558 flagellar protein FliS; Validated; Region: fliS; PRK05685 716541004559 flagellar capping protein; Reviewed; Region: fliD; PRK08032 716541004560 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 716541004561 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 716541004562 flagellin; Validated; Region: PRK06819 716541004563 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 716541004564 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 716541004565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541004566 S-adenosylmethionine binding site [chemical binding]; other site 716541004567 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 716541004568 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 716541004569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 716541004570 binding surface 716541004571 TPR motif; other site 716541004572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 716541004573 binding surface 716541004574 TPR motif; other site 716541004575 TPR repeat; Region: TPR_11; pfam13414 716541004576 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 716541004577 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 716541004578 inhibitor-cofactor binding pocket; inhibition site 716541004579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541004580 catalytic residue [active] 716541004581 WbqC-like protein family; Region: WbqC; pfam08889 716541004582 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 716541004583 active site 716541004584 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 716541004585 active site 716541004586 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 716541004587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541004588 Coenzyme A binding pocket [chemical binding]; other site 716541004589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541004590 S-adenosylmethionine binding site [chemical binding]; other site 716541004591 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 716541004592 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 716541004593 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 716541004594 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 716541004595 DNA binding residues [nucleotide binding] 716541004596 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 716541004597 cystine transporter subunit; Provisional; Region: PRK11260 716541004598 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541004599 substrate binding pocket [chemical binding]; other site 716541004600 membrane-bound complex binding site; other site 716541004601 hinge residues; other site 716541004602 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 716541004603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541004604 catalytic residue [active] 716541004605 amino acid ABC transporter permease; Provisional; Region: PRK15100 716541004606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541004607 dimer interface [polypeptide binding]; other site 716541004608 conserved gate region; other site 716541004609 putative PBP binding loops; other site 716541004610 ABC-ATPase subunit interface; other site 716541004611 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 716541004612 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 716541004613 Walker A/P-loop; other site 716541004614 ATP binding site [chemical binding]; other site 716541004615 Q-loop/lid; other site 716541004616 ABC transporter signature motif; other site 716541004617 Walker B; other site 716541004618 D-loop; other site 716541004619 H-loop/switch region; other site 716541004620 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 716541004621 Autoinducer binding domain; Region: Autoind_bind; pfam03472 716541004622 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541004623 DNA binding residues [nucleotide binding] 716541004624 dimerization interface [polypeptide binding]; other site 716541004625 hypothetical protein; Provisional; Region: PRK10613 716541004626 response regulator; Provisional; Region: PRK09483 716541004627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541004628 active site 716541004629 phosphorylation site [posttranslational modification] 716541004630 intermolecular recognition site; other site 716541004631 dimerization interface [polypeptide binding]; other site 716541004632 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541004633 DNA binding residues [nucleotide binding] 716541004634 dimerization interface [polypeptide binding]; other site 716541004635 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 716541004636 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 716541004637 GIY-YIG motif/motif A; other site 716541004638 active site 716541004639 catalytic site [active] 716541004640 putative DNA binding site [nucleotide binding]; other site 716541004641 metal binding site [ion binding]; metal-binding site 716541004642 UvrB/uvrC motif; Region: UVR; pfam02151 716541004643 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 716541004644 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 716541004645 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 716541004646 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 716541004647 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 716541004648 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 716541004649 Walker A/P-loop; other site 716541004650 ATP binding site [chemical binding]; other site 716541004651 Q-loop/lid; other site 716541004652 ABC transporter signature motif; other site 716541004653 Walker B; other site 716541004654 D-loop; other site 716541004655 H-loop/switch region; other site 716541004656 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 716541004657 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 716541004658 Walker A/P-loop; other site 716541004659 ATP binding site [chemical binding]; other site 716541004660 Q-loop/lid; other site 716541004661 ABC transporter signature motif; other site 716541004662 Walker B; other site 716541004663 D-loop; other site 716541004664 H-loop/switch region; other site 716541004665 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 716541004666 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 716541004667 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 716541004668 TM-ABC transporter signature motif; other site 716541004669 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 716541004670 TM-ABC transporter signature motif; other site 716541004671 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 716541004672 dimerization interface [polypeptide binding]; other site 716541004673 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 716541004674 ligand binding site [chemical binding]; other site 716541004675 hypothetical protein; Provisional; Region: PRK10396 716541004676 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 716541004677 SEC-C motif; Region: SEC-C; pfam02810 716541004678 tyrosine transporter TyrP; Provisional; Region: PRK15132 716541004679 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 716541004680 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 716541004681 Ferritin-like domain; Region: Ferritin; pfam00210 716541004682 ferroxidase diiron center [ion binding]; other site 716541004683 YecR-like lipoprotein; Region: YecR; pfam13992 716541004684 hypothetical protein; Provisional; Region: PRK09273 716541004685 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 716541004686 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 716541004687 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 716541004688 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 716541004689 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 716541004690 Ferritin-like domain; Region: Ferritin; pfam00210 716541004691 ferroxidase diiron center [ion binding]; other site 716541004692 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541004693 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541004694 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 716541004695 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 716541004696 ligand binding site [chemical binding]; other site 716541004697 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 716541004698 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 716541004699 Walker A/P-loop; other site 716541004700 ATP binding site [chemical binding]; other site 716541004701 Q-loop/lid; other site 716541004702 ABC transporter signature motif; other site 716541004703 Walker B; other site 716541004704 D-loop; other site 716541004705 H-loop/switch region; other site 716541004706 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 716541004707 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 716541004708 TM-ABC transporter signature motif; other site 716541004709 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 716541004710 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 716541004711 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 716541004712 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 716541004713 active site 716541004714 homotetramer interface [polypeptide binding]; other site 716541004715 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 716541004716 Ligand Binding Site [chemical binding]; other site 716541004717 transcriptional activator FlhD; Provisional; Region: PRK02909 716541004718 transcriptional activator FlhC; Provisional; Region: PRK12722 716541004719 flagellar motor protein MotA; Validated; Region: PRK09110 716541004720 flagellar motor protein MotB; Validated; Region: motB; PRK09041 716541004721 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 716541004722 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 716541004723 ligand binding site [chemical binding]; other site 716541004724 chemotaxis protein CheA; Provisional; Region: PRK10547 716541004725 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 716541004726 putative binding surface; other site 716541004727 active site 716541004728 CheY binding; Region: CheY-binding; pfam09078 716541004729 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 716541004730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541004731 ATP binding site [chemical binding]; other site 716541004732 Mg2+ binding site [ion binding]; other site 716541004733 G-X-G motif; other site 716541004734 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 716541004735 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 716541004736 putative CheA interaction surface; other site 716541004737 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 716541004738 Spore Coat Protein U domain; Region: SCPU; pfam05229 716541004739 Spore Coat Protein U domain; Region: SCPU; pfam05229 716541004740 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 716541004741 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 716541004742 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 716541004743 Outer membrane usher protein; Region: Usher; pfam00577 716541004744 PapC C-terminal domain; Region: PapC_C; pfam13953 716541004745 Spore Coat Protein U domain; Region: SCPU; cl02253 716541004746 Spore Coat Protein U domain; Region: SCPU; pfam05229 716541004747 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 716541004748 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 716541004749 dimer interface [polypeptide binding]; other site 716541004750 ligand binding site [chemical binding]; other site 716541004751 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541004752 dimerization interface [polypeptide binding]; other site 716541004753 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716541004754 dimer interface [polypeptide binding]; other site 716541004755 putative CheW interface [polypeptide binding]; other site 716541004756 methyl-accepting protein IV; Provisional; Region: PRK09793 716541004757 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 716541004758 dimer interface [polypeptide binding]; other site 716541004759 ligand binding site [chemical binding]; other site 716541004760 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541004761 dimerization interface [polypeptide binding]; other site 716541004762 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716541004763 dimer interface [polypeptide binding]; other site 716541004764 putative CheW interface [polypeptide binding]; other site 716541004765 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 716541004766 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 716541004767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541004768 S-adenosylmethionine binding site [chemical binding]; other site 716541004769 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 716541004770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541004771 active site 716541004772 phosphorylation site [posttranslational modification] 716541004773 intermolecular recognition site; other site 716541004774 dimerization interface [polypeptide binding]; other site 716541004775 CheB methylesterase; Region: CheB_methylest; pfam01339 716541004776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541004777 active site 716541004778 phosphorylation site [posttranslational modification] 716541004779 intermolecular recognition site; other site 716541004780 dimerization interface [polypeptide binding]; other site 716541004781 chemotaxis regulator CheZ; Provisional; Region: PRK11166 716541004782 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 716541004783 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 716541004784 Flagellar protein FlhE; Region: FlhE; pfam06366 716541004785 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 716541004786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541004787 putative substrate translocation pore; other site 716541004788 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 716541004789 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 716541004790 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 716541004791 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 716541004792 active site 716541004793 HIGH motif; other site 716541004794 KMSK motif region; other site 716541004795 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 716541004796 tRNA binding surface [nucleotide binding]; other site 716541004797 anticodon binding site; other site 716541004798 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 716541004799 putative metal binding site [ion binding]; other site 716541004800 copper homeostasis protein CutC; Provisional; Region: PRK11572 716541004801 tRNA (mo5U34)-methyltransferase; Region: TIGR00452 716541004802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541004803 S-adenosylmethionine binding site [chemical binding]; other site 716541004804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541004805 S-adenosylmethionine binding site [chemical binding]; other site 716541004806 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 716541004807 hypothetical protein; Provisional; Region: PRK10302 716541004808 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 716541004809 catalytic triad [active] 716541004810 conserved cis-peptide bond; other site 716541004811 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 716541004812 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 716541004813 dimer interface [polypeptide binding]; other site 716541004814 anticodon binding site; other site 716541004815 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 716541004816 homodimer interface [polypeptide binding]; other site 716541004817 motif 1; other site 716541004818 active site 716541004819 motif 2; other site 716541004820 GAD domain; Region: GAD; pfam02938 716541004821 motif 3; other site 716541004822 dihydroneopterin triphosphate pyrophosphatase; Provisional; Region: nudB; PRK09438 716541004823 hypothetical protein; Validated; Region: PRK00110 716541004824 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 716541004825 active site 716541004826 putative DNA-binding cleft [nucleotide binding]; other site 716541004827 dimer interface [polypeptide binding]; other site 716541004828 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 716541004829 RuvA N terminal domain; Region: RuvA_N; pfam01330 716541004830 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 716541004831 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 716541004832 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 716541004833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541004834 Walker A motif; other site 716541004835 ATP binding site [chemical binding]; other site 716541004836 Walker B motif; other site 716541004837 arginine finger; other site 716541004838 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 716541004839 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716541004840 ABC-ATPase subunit interface; other site 716541004841 dimer interface [polypeptide binding]; other site 716541004842 putative PBP binding regions; other site 716541004843 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 716541004844 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 716541004845 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 716541004846 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 716541004847 metal binding site [ion binding]; metal-binding site 716541004848 putative peptidase; Provisional; Region: PRK11649 716541004849 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 716541004850 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 716541004851 Peptidase family M23; Region: Peptidase_M23; pfam01551 716541004852 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 716541004853 putative acyl-acceptor binding pocket; other site 716541004854 pyruvate kinase; Provisional; Region: PRK05826 716541004855 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 716541004856 domain interfaces; other site 716541004857 active site 716541004858 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 716541004859 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 716541004860 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 716541004861 putative active site [active] 716541004862 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 716541004863 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 716541004864 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 716541004865 phosphogluconate dehydratase; Validated; Region: PRK09054 716541004866 Entner-Doudoroff aldolase; Region: eda; TIGR01182 716541004867 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 716541004868 active site 716541004869 intersubunit interface [polypeptide binding]; other site 716541004870 catalytic residue [active] 716541004871 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 716541004872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716541004873 ATP-grasp domain; Region: ATP-grasp; pfam02222 716541004874 Protein of unknown function (DUF533); Region: DUF533; pfam04391 716541004875 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 716541004876 putative metal binding site [ion binding]; other site 716541004877 protease 2; Provisional; Region: PRK10115 716541004878 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 716541004879 exodeoxyribonuclease X; Provisional; Region: PRK07983 716541004880 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 716541004881 active site 716541004882 catalytic site [active] 716541004883 substrate binding site [chemical binding]; other site 716541004884 Predicted amidohydrolase [General function prediction only]; Region: COG0388 716541004885 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 716541004886 CopC domain; Region: CopC; cl01012 716541004887 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 716541004888 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 716541004889 Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724 716541004890 Protein of unknown function (DUF535); Region: DUF535; pfam04393 716541004891 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 716541004892 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 716541004893 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 716541004894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541004895 S-adenosylmethionine binding site [chemical binding]; other site 716541004896 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl19835 716541004897 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 716541004898 mce related protein; Region: MCE; pfam02470 716541004899 mce related protein; Region: MCE; pfam02470 716541004900 mce related protein; Region: MCE; pfam02470 716541004901 mce related protein; Region: MCE; pfam02470 716541004902 mce related protein; Region: MCE; pfam02470 716541004903 mce related protein; Region: MCE; pfam02470 716541004904 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 716541004905 Paraquat-inducible protein A; Region: PqiA; pfam04403 716541004906 Paraquat-inducible protein A; Region: PqiA; pfam04403 716541004907 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 716541004908 ProP expression regulator; Provisional; Region: PRK04950 716541004909 putative RNA binding sites [nucleotide binding]; other site 716541004910 carboxy-terminal protease; Provisional; Region: PRK11186 716541004911 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 716541004912 protein binding site [polypeptide binding]; other site 716541004913 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 716541004914 Catalytic dyad [active] 716541004915 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 716541004916 heat shock protein HtpX; Provisional; Region: PRK05457 716541004917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541004918 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716541004919 putative substrate translocation pore; other site 716541004920 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 716541004921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716541004922 dimerization interface [polypeptide binding]; other site 716541004923 putative Zn2+ binding site [ion binding]; other site 716541004924 putative DNA binding site [nucleotide binding]; other site 716541004925 Bacterial transcriptional regulator; Region: IclR; pfam01614 716541004926 YobH-like protein; Region: YobH; pfam13996 716541004927 PhoPQ regulatory protein; Provisional; Region: PRK10299 716541004928 YebO-like protein; Region: YebO; pfam13974 716541004929 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 716541004930 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 716541004931 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 716541004932 DNA-binding site [nucleotide binding]; DNA binding site 716541004933 RNA-binding motif; other site 716541004934 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 716541004935 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 716541004936 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 716541004937 Methyltransferase domain; Region: Methyltransf_31; pfam13847 716541004938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541004939 S-adenosylmethionine binding site [chemical binding]; other site 716541004940 hypothetical protein; Provisional; Region: PRK11469 716541004941 Domain of unknown function DUF; Region: DUF204; pfam02659 716541004942 Domain of unknown function DUF; Region: DUF204; pfam02659 716541004943 hypothetical protein; Provisional; Region: PRK02913 716541004944 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 716541004945 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 716541004946 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 716541004947 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 716541004948 active pocket/dimerization site; other site 716541004949 active site 716541004950 phosphorylation site [posttranslational modification] 716541004951 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 716541004952 active site 716541004953 phosphorylation site [posttranslational modification] 716541004954 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 716541004955 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 716541004956 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 716541004957 Transporter associated domain; Region: CorC_HlyC; smart01091 716541004958 phage resistance protein; Provisional; Region: PRK10551 716541004959 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 716541004960 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541004961 L-serine deaminase; Provisional; Region: PRK15023 716541004962 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 716541004963 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 716541004964 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 716541004965 putative active site [active] 716541004966 putative CoA binding site [chemical binding]; other site 716541004967 nudix motif; other site 716541004968 metal binding site [ion binding]; metal-binding site 716541004969 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 716541004970 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 716541004971 chorismate binding enzyme; Region: Chorismate_bind; cl10555 716541004972 hypothetical protein; Provisional; Region: PRK05114 716541004973 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 716541004974 homotrimer interaction site [polypeptide binding]; other site 716541004975 putative active site [active] 716541004976 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 716541004977 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 716541004978 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 716541004979 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 716541004980 Glycoprotease family; Region: Peptidase_M22; pfam00814 716541004981 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 716541004982 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 716541004983 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 716541004984 acyl-activating enzyme (AAE) consensus motif; other site 716541004985 putative AMP binding site [chemical binding]; other site 716541004986 putative active site [active] 716541004987 putative CoA binding site [chemical binding]; other site 716541004988 ribonuclease D; Provisional; Region: PRK10829 716541004989 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 716541004990 catalytic site [active] 716541004991 putative active site [active] 716541004992 putative substrate binding site [chemical binding]; other site 716541004993 Helicase and RNase D C-terminal; Region: HRDC; smart00341 716541004994 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 716541004995 cell division inhibitor MinD; Provisional; Region: PRK10818 716541004996 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 716541004997 P-loop; other site 716541004998 ADP binding residues [chemical binding]; other site 716541004999 Switch I; other site 716541005000 Switch II; other site 716541005001 septum formation inhibitor; Reviewed; Region: minC; PRK03511 716541005002 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 716541005003 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 716541005004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 716541005005 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 716541005006 hypothetical protein; Provisional; Region: PRK10691 716541005007 hypothetical protein; Provisional; Region: PRK05170 716541005008 disulfide bond formation protein B; Provisional; Region: PRK01749 716541005009 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 716541005010 fatty acid metabolism regulator; Provisional; Region: PRK04984 716541005011 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541005012 DNA-binding site [nucleotide binding]; DNA binding site 716541005013 FadR C-terminal domain; Region: FadR_C; pfam07840 716541005014 SpoVR family protein; Provisional; Region: PRK11767 716541005015 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 716541005016 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541005017 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541005018 alanine racemase; Reviewed; Region: dadX; PRK03646 716541005019 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 716541005020 active site 716541005021 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 716541005022 substrate binding site [chemical binding]; other site 716541005023 catalytic residues [active] 716541005024 dimer interface [polypeptide binding]; other site 716541005025 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 716541005026 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 716541005027 TrkA-C domain; Region: TrkA_C; pfam02080 716541005028 Transporter associated domain; Region: CorC_HlyC; smart01091 716541005029 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 716541005030 dimer interface [polypeptide binding]; other site 716541005031 catalytic triad [active] 716541005032 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716541005033 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716541005034 catalytic residue [active] 716541005035 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 716541005036 Flagellar regulator YcgR; Region: YcgR; pfam07317 716541005037 PilZ domain; Region: PilZ; pfam07238 716541005038 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 716541005039 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 716541005040 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 716541005041 N-terminal plug; other site 716541005042 ligand-binding site [chemical binding]; other site 716541005043 trehalase; Provisional; Region: treA; PRK13271 716541005044 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 716541005045 putative symporter YagG; Provisional; Region: PRK09669; cl15392 716541005046 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 716541005047 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 716541005048 Cupin; Region: Cupin_6; pfam12852 716541005049 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 716541005050 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541005051 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 716541005052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541005053 putative substrate translocation pore; other site 716541005054 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 716541005055 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 716541005056 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 716541005057 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 716541005058 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 716541005059 conserved cys residue [active] 716541005060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541005061 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 716541005062 putative di-iron ligands [ion binding]; other site 716541005063 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 716541005064 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 716541005065 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 716541005066 putative molybdopterin cofactor binding site [chemical binding]; other site 716541005067 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 716541005068 putative molybdopterin cofactor binding site; other site 716541005069 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 716541005070 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 716541005071 hypothetical protein; Provisional; Region: PRK07033 716541005072 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 716541005073 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 716541005074 ligand binding site [chemical binding]; other site 716541005075 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 716541005076 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 716541005077 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 716541005078 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 716541005079 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 716541005080 ImpA-related N-terminal; Region: ImpA-rel_N; cl19907 716541005081 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 716541005082 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 716541005083 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 716541005084 Protein of unknown function (DUF796); Region: DUF796; pfam05638 716541005085 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 716541005086 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 716541005087 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 716541005088 phosphopeptide binding site; other site 716541005089 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 716541005090 active site 716541005091 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 716541005092 ImpE protein; Region: ImpE; pfam07024 716541005093 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 716541005094 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 716541005095 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 716541005096 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 716541005097 Clp amino terminal domain; Region: Clp_N; pfam02861 716541005098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541005099 Walker A motif; other site 716541005100 ATP binding site [chemical binding]; other site 716541005101 Walker B motif; other site 716541005102 arginine finger; other site 716541005103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541005104 Walker A motif; other site 716541005105 ATP binding site [chemical binding]; other site 716541005106 Walker B motif; other site 716541005107 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 716541005108 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 716541005109 Catalytic domain of Protein Kinases; Region: PKc; cd00180 716541005110 active site 716541005111 ATP binding site [chemical binding]; other site 716541005112 substrate binding site [chemical binding]; other site 716541005113 activation loop (A-loop); other site 716541005114 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 716541005115 nucleophilic elbow; other site 716541005116 catalytic triad; other site 716541005117 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 716541005118 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 716541005119 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 716541005120 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541005121 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541005122 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 716541005123 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 716541005124 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 716541005125 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541005126 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541005127 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 716541005128 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 716541005129 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 716541005130 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 716541005131 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 716541005132 PAAR motif; Region: PAAR_motif; pfam05488 716541005133 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 716541005134 RHS Repeat; Region: RHS_repeat; pfam05593 716541005135 RHS Repeat; Region: RHS_repeat; pfam05593 716541005136 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 716541005137 RHS Repeat; Region: RHS_repeat; pfam05593 716541005138 RHS Repeat; Region: RHS_repeat; pfam05593 716541005139 RHS Repeat; Region: RHS_repeat; pfam05593 716541005140 RHS Repeat; Region: RHS_repeat; pfam05593 716541005141 RHS Repeat; Region: RHS_repeat; pfam05593 716541005142 RHS protein; Region: RHS; pfam03527 716541005143 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 716541005144 Immunity protein 14; Region: Imm14; pfam15428 716541005145 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 716541005146 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 716541005147 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541005148 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541005149 YCII-related domain; Region: YCII; cl00999 716541005150 GTP-binding protein YchF; Reviewed; Region: PRK09601 716541005151 YchF GTPase; Region: YchF; cd01900 716541005152 G1 box; other site 716541005153 GTP/Mg2+ binding site [chemical binding]; other site 716541005154 Switch I region; other site 716541005155 G2 box; other site 716541005156 Switch II region; other site 716541005157 G3 box; other site 716541005158 G4 box; other site 716541005159 G5 box; other site 716541005160 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 716541005161 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 716541005162 putative active site [active] 716541005163 catalytic residue [active] 716541005164 hypothetical protein; Provisional; Region: PRK10692 716541005165 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 716541005166 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 716541005167 DNA binding residues [nucleotide binding] 716541005168 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 716541005169 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 716541005170 putative transporter; Provisional; Region: PRK11660 716541005171 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 716541005172 Sulfate transporter family; Region: Sulfate_transp; pfam00916 716541005173 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 716541005174 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 716541005175 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 716541005176 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 716541005177 active site 716541005178 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 716541005179 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 716541005180 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 716541005181 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 716541005182 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 716541005183 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 716541005184 tRNA; other site 716541005185 putative tRNA binding site [nucleotide binding]; other site 716541005186 putative NADP binding site [chemical binding]; other site 716541005187 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 716541005188 peptide chain release factor 1; Validated; Region: prfA; PRK00591 716541005189 This domain is found in peptide chain release factors; Region: PCRF; smart00937 716541005190 RF-1 domain; Region: RF-1; pfam00472 716541005191 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 716541005192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541005193 S-adenosylmethionine binding site [chemical binding]; other site 716541005194 hypothetical protein; Provisional; Region: PRK10278 716541005195 hypothetical protein; Provisional; Region: PRK10941 716541005196 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 716541005197 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 716541005198 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 716541005199 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 716541005200 cation transport regulator; Reviewed; Region: chaB; PRK09582 716541005201 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 716541005202 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 716541005203 putative active site pocket [active] 716541005204 dimerization interface [polypeptide binding]; other site 716541005205 putative catalytic residue [active] 716541005206 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 716541005207 Cache domain; Region: Cache_1; pfam02743 716541005208 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541005209 dimerization interface [polypeptide binding]; other site 716541005210 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 716541005211 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716541005212 dimer interface [polypeptide binding]; other site 716541005213 putative CheW interface [polypeptide binding]; other site 716541005214 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 716541005215 Nitrate and nitrite sensing; Region: NIT; pfam08376 716541005216 ANTAR domain; Region: ANTAR; pfam03861 716541005217 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 716541005218 NMT1-like family; Region: NMT1_2; pfam13379 716541005219 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 716541005220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541005221 dimer interface [polypeptide binding]; other site 716541005222 conserved gate region; other site 716541005223 putative PBP binding loops; other site 716541005224 ABC-ATPase subunit interface; other site 716541005225 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 716541005226 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 716541005227 Walker A/P-loop; other site 716541005228 ATP binding site [chemical binding]; other site 716541005229 Q-loop/lid; other site 716541005230 ABC transporter signature motif; other site 716541005231 Walker B; other site 716541005232 D-loop; other site 716541005233 H-loop/switch region; other site 716541005234 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 716541005235 nitrite reductase subunit NirD; Provisional; Region: PRK14989 716541005236 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541005237 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716541005238 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 716541005239 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 716541005240 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 716541005241 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 716541005242 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 716541005243 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 716541005244 [4Fe-4S] binding site [ion binding]; other site 716541005245 molybdopterin cofactor binding site; other site 716541005246 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 716541005247 molybdopterin cofactor binding site; other site 716541005248 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 716541005249 putative invasin; Provisional; Region: PRK10177 716541005250 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 716541005251 transcriptional regulator NarL; Provisional; Region: PRK10651 716541005252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541005253 active site 716541005254 phosphorylation site [posttranslational modification] 716541005255 intermolecular recognition site; other site 716541005256 dimerization interface [polypeptide binding]; other site 716541005257 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541005258 DNA binding residues [nucleotide binding] 716541005259 dimerization interface [polypeptide binding]; other site 716541005260 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 716541005261 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 716541005262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541005263 dimerization interface [polypeptide binding]; other site 716541005264 Histidine kinase; Region: HisKA_3; pfam07730 716541005265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541005266 ATP binding site [chemical binding]; other site 716541005267 Mg2+ binding site [ion binding]; other site 716541005268 G-X-G motif; other site 716541005269 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 716541005270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541005271 putative substrate translocation pore; other site 716541005272 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 716541005273 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 716541005274 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 716541005275 [4Fe-4S] binding site [ion binding]; other site 716541005276 molybdopterin cofactor binding site [chemical binding]; other site 716541005277 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 716541005278 molybdopterin cofactor binding site; other site 716541005279 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 716541005280 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 716541005281 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 716541005282 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 716541005283 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 716541005284 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 716541005285 EamA-like transporter family; Region: EamA; pfam00892 716541005286 EamA-like transporter family; Region: EamA; pfam00892 716541005287 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 716541005288 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 716541005289 putative DNA binding site [nucleotide binding]; other site 716541005290 putative Zn2+ binding site [ion binding]; other site 716541005291 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 716541005292 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 716541005293 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 716541005294 putative active site [active] 716541005295 putative substrate binding site [chemical binding]; other site 716541005296 putative cosubstrate binding site; other site 716541005297 catalytic site [active] 716541005298 SEC-C motif; Region: SEC-C; cl19389 716541005299 SEC-C motif; Region: SEC-C; cl19389 716541005300 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 716541005301 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 716541005302 active site 716541005303 nucleophile elbow; other site 716541005304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541005305 active site 716541005306 response regulator of RpoS; Provisional; Region: PRK10693 716541005307 phosphorylation site [posttranslational modification] 716541005308 intermolecular recognition site; other site 716541005309 dimerization interface [polypeptide binding]; other site 716541005310 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 716541005311 tetramer interface; other site 716541005312 active site 716541005313 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 716541005314 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 716541005315 thymidine kinase; Provisional; Region: PRK04296 716541005316 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 716541005317 Coenzyme A acylating aldehyde dehydrogenase (ACDH), Ethanolamine utilization protein EutE, and related proteins; Region: ALDH_F20_ACDH_EutE-like; cd07081 716541005318 putative catalytic cysteine [active] 716541005319 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 716541005320 putative active site [active] 716541005321 metal binding site [ion binding]; metal-binding site 716541005322 hypothetical protein; Provisional; Region: PRK11111 716541005323 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 716541005324 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 716541005325 peptide binding site [polypeptide binding]; other site 716541005326 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 716541005327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541005328 dimer interface [polypeptide binding]; other site 716541005329 conserved gate region; other site 716541005330 putative PBP binding loops; other site 716541005331 ABC-ATPase subunit interface; other site 716541005332 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 716541005333 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 716541005334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541005335 dimer interface [polypeptide binding]; other site 716541005336 conserved gate region; other site 716541005337 putative PBP binding loops; other site 716541005338 ABC-ATPase subunit interface; other site 716541005339 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 716541005340 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716541005341 Walker A/P-loop; other site 716541005342 ATP binding site [chemical binding]; other site 716541005343 Q-loop/lid; other site 716541005344 ABC transporter signature motif; other site 716541005345 Walker B; other site 716541005346 D-loop; other site 716541005347 H-loop/switch region; other site 716541005348 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 716541005349 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 716541005350 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716541005351 Walker A/P-loop; other site 716541005352 ATP binding site [chemical binding]; other site 716541005353 Q-loop/lid; other site 716541005354 ABC transporter signature motif; other site 716541005355 Walker B; other site 716541005356 D-loop; other site 716541005357 H-loop/switch region; other site 716541005358 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 716541005359 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 716541005360 Ion transport protein; Region: Ion_trans; pfam00520 716541005361 Ion channel; Region: Ion_trans_2; pfam07885 716541005362 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 716541005363 Double zinc ribbon; Region: DZR; pfam12773 716541005364 dsDNA-mimic protein; Reviewed; Region: PRK05094 716541005365 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 716541005366 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 716541005367 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 716541005368 putative active site [active] 716541005369 catalytic site [active] 716541005370 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 716541005371 putative active site [active] 716541005372 catalytic site [active] 716541005373 leucine export protein LeuE; Provisional; Region: PRK10958 716541005374 YciI-like protein; Reviewed; Region: PRK11370 716541005375 transport protein TonB; Provisional; Region: PRK10819 716541005376 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 716541005377 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 716541005378 intracellular septation protein A; Reviewed; Region: PRK00259 716541005379 hypothetical protein; Provisional; Region: PRK02868 716541005380 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 716541005381 outer membrane protein W; Provisional; Region: PRK10959 716541005382 TolA C-terminal; Region: TolA; pfam06519 716541005383 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 716541005384 Ligand Binding Site [chemical binding]; other site 716541005385 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 716541005386 CPxP motif; other site 716541005387 putative inner membrane protein; Provisional; Region: PRK11099 716541005388 Predicted transporter component [General function prediction only]; Region: COG2391 716541005389 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 716541005390 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 716541005391 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 716541005392 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 716541005393 dimer interface [polypeptide binding]; other site 716541005394 active site 716541005395 Int/Topo IB signature motif; other site 716541005396 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 716541005397 exonuclease VIII; Reviewed; Region: PRK09709 716541005398 transcriptional repressor DicA; Reviewed; Region: PRK09706 716541005399 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 716541005400 primosomal protein DnaI; Provisional; Region: PRK02854 716541005401 putative replication protein; Provisional; Region: PRK12377 716541005402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541005403 Walker A motif; other site 716541005404 ATP binding site [chemical binding]; other site 716541005405 Walker B motif; other site 716541005406 arginine finger; other site 716541005407 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 716541005408 Methyltransferase domain; Region: Methyltransf_25; pfam13649 716541005409 Protein of unknown function (DUF968); Region: DUF968; pfam06147 716541005410 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 716541005411 Protein of unknown function (DUF754); Region: DUF754; pfam05449 716541005412 Predicted chitinase [General function prediction only]; Region: COG3179 716541005413 catalytic residue [active] 716541005414 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 716541005415 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 716541005416 active site 716541005417 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 716541005418 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 716541005419 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 716541005420 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 716541005421 oligomer interface [polypeptide binding]; other site 716541005422 active site residues [active] 716541005423 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 716541005424 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 716541005425 active site 716541005426 Int/Topo IB signature motif; other site 716541005427 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 716541005428 AAA domain; Region: AAA_25; pfam13481 716541005429 Walker A motif; other site 716541005430 ATP binding site [chemical binding]; other site 716541005431 Walker B motif; other site 716541005432 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 716541005433 oligomer interface [polypeptide binding]; other site 716541005434 active site residues [active] 716541005435 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 716541005436 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 716541005437 IS2 transposase TnpB; Reviewed; Region: PRK09409 716541005438 HTH-like domain; Region: HTH_21; pfam13276 716541005439 Integrase core domain; Region: rve; pfam00665 716541005440 Integrase core domain; Region: rve_3; pfam13683 716541005441 Transposase; Region: HTH_Tnp_1; cl17663 716541005442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541005443 Phage-related protein, tail component [Function unknown]; Region: COG4723 716541005444 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 716541005445 active site residues [active] 716541005446 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 716541005447 Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289 716541005448 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 716541005449 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 716541005450 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 716541005451 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 716541005452 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 716541005453 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 716541005454 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 716541005455 Phage-related minor tail protein [Function unknown]; Region: COG5281 716541005456 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 716541005457 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 716541005458 Phage minor tail protein; Region: Phage_min_tail; pfam05939 716541005459 Phage minor tail protein L; Region: Phage_tail_L; pfam05100 716541005460 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 716541005461 MPN+ (JAMM) motif; other site 716541005462 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 716541005463 Zinc-binding site [ion binding]; other site 716541005464 NlpC/P60 family; Region: NLPC_P60; pfam00877 716541005465 Phage-related protein, tail component [Function unknown]; Region: COG4723 716541005466 Phage-related protein, tail component [Function unknown]; Region: COG4733 716541005467 Putative phage tail protein; Region: Phage-tail_3; pfam13550 716541005468 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 716541005469 Interdomain contacts; other site 716541005470 Cytokine receptor motif; other site 716541005471 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 716541005472 Fibronectin type III protein; Region: DUF3672; pfam12421 716541005473 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 716541005474 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 716541005475 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 716541005476 Presynaptic Site I dimer interface [polypeptide binding]; other site 716541005477 catalytic residues [active] 716541005478 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 716541005479 Synaptic Flat tetramer interface [polypeptide binding]; other site 716541005480 Synaptic Site I dimer interface [polypeptide binding]; other site 716541005481 DNA binding site [nucleotide binding] 716541005482 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 716541005483 DNA-binding interface [nucleotide binding]; DNA binding site 716541005484 DinI-like family; Region: DinI; pfam06183 716541005485 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 716541005486 Resolvase, N terminal domain; Region: Resolvase; pfam00239 716541005487 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 716541005488 DNA-binding interface [nucleotide binding]; DNA binding site 716541005489 Phage anti-repressor protein [Transcription]; Region: COG3561 716541005490 Ash protein family; Region: Phage_ASH; pfam10554 716541005491 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 716541005492 substrate binding site [chemical binding]; other site 716541005493 active site 716541005494 catalytic residues [active] 716541005495 heterodimer interface [polypeptide binding]; other site 716541005496 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 716541005497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541005498 catalytic residue [active] 716541005499 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 716541005500 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 716541005501 active site 716541005502 ribulose/triose binding site [chemical binding]; other site 716541005503 phosphate binding site [ion binding]; other site 716541005504 substrate (anthranilate) binding pocket [chemical binding]; other site 716541005505 product (indole) binding pocket [chemical binding]; other site 716541005506 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 716541005507 active site 716541005508 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 716541005509 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 716541005510 glutamine binding [chemical binding]; other site 716541005511 catalytic triad [active] 716541005512 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 716541005513 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 716541005514 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 716541005515 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 716541005516 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 716541005517 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 716541005518 active site 716541005519 hypothetical protein; Provisional; Region: PRK11630 716541005520 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 716541005521 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 716541005522 RNA binding surface [nucleotide binding]; other site 716541005523 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 716541005524 probable active site [active] 716541005525 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 716541005526 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 716541005527 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 716541005528 homodimer interface [polypeptide binding]; other site 716541005529 Walker A motif; other site 716541005530 ATP binding site [chemical binding]; other site 716541005531 hydroxycobalamin binding site [chemical binding]; other site 716541005532 Walker B motif; other site 716541005533 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 716541005534 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 716541005535 NADP binding site [chemical binding]; other site 716541005536 homodimer interface [polypeptide binding]; other site 716541005537 active site 716541005538 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 716541005539 putative inner membrane peptidase; Provisional; Region: PRK11778 716541005540 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 716541005541 tandem repeat interface [polypeptide binding]; other site 716541005542 oligomer interface [polypeptide binding]; other site 716541005543 active site residues [active] 716541005544 hypothetical protein; Provisional; Region: PRK11037 716541005545 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 716541005546 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 716541005547 active site 716541005548 interdomain interaction site; other site 716541005549 putative metal-binding site [ion binding]; other site 716541005550 nucleotide binding site [chemical binding]; other site 716541005551 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 716541005552 domain I; other site 716541005553 DNA binding groove [nucleotide binding] 716541005554 phosphate binding site [ion binding]; other site 716541005555 domain II; other site 716541005556 domain III; other site 716541005557 nucleotide binding site [chemical binding]; other site 716541005558 catalytic site [active] 716541005559 domain IV; other site 716541005560 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 716541005561 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 716541005562 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 716541005563 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 716541005564 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 716541005565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541005566 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 716541005567 substrate binding site [chemical binding]; other site 716541005568 putative dimerization interface [polypeptide binding]; other site 716541005569 aconitate hydratase; Validated; Region: PRK09277 716541005570 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 716541005571 substrate binding site [chemical binding]; other site 716541005572 ligand binding site [chemical binding]; other site 716541005573 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 716541005574 substrate binding site [chemical binding]; other site 716541005575 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 716541005576 dimerization interface [polypeptide binding]; other site 716541005577 active site 716541005578 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 716541005579 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 716541005580 active site 716541005581 Predicted membrane protein [Function unknown]; Region: COG3771 716541005582 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 716541005583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 716541005584 binding surface 716541005585 TPR motif; other site 716541005586 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 716541005587 active site 716541005588 dimer interface [polypeptide binding]; other site 716541005589 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 716541005590 putative rRNA binding site [nucleotide binding]; other site 716541005591 lipoprotein; Provisional; Region: PRK10540 716541005592 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 716541005593 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 716541005594 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 716541005595 hypothetical protein; Provisional; Region: PRK13658 716541005596 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 716541005597 substrate binding site [chemical binding]; other site 716541005598 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 716541005599 oxyanion hole (OAH) forming residues; other site 716541005600 trimer interface [polypeptide binding]; other site 716541005601 RNase II stability modulator; Provisional; Region: PRK10060 716541005602 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716541005603 putative active site [active] 716541005604 heme pocket [chemical binding]; other site 716541005605 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541005606 metal binding site [ion binding]; metal-binding site 716541005607 active site 716541005608 I-site; other site 716541005609 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541005610 exoribonuclease II; Provisional; Region: PRK05054 716541005611 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 716541005612 RNB domain; Region: RNB; pfam00773 716541005613 S1 RNA binding domain; Region: S1; pfam00575 716541005614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 716541005615 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 716541005616 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 716541005617 NAD binding site [chemical binding]; other site 716541005618 homotetramer interface [polypeptide binding]; other site 716541005619 homodimer interface [polypeptide binding]; other site 716541005620 substrate binding site [chemical binding]; other site 716541005621 active site 716541005622 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 716541005623 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 716541005624 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 716541005625 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 716541005626 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 716541005627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541005628 active site 716541005629 phosphorylation site [posttranslational modification] 716541005630 intermolecular recognition site; other site 716541005631 dimerization interface [polypeptide binding]; other site 716541005632 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541005633 DNA binding site [nucleotide binding] 716541005634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 716541005635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541005636 dimerization interface [polypeptide binding]; other site 716541005637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541005638 dimer interface [polypeptide binding]; other site 716541005639 phosphorylation site [posttranslational modification] 716541005640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541005641 ATP binding site [chemical binding]; other site 716541005642 Mg2+ binding site [ion binding]; other site 716541005643 G-X-G motif; other site 716541005644 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 716541005645 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541005646 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541005647 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 716541005648 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 716541005649 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716541005650 Walker A/P-loop; other site 716541005651 ATP binding site [chemical binding]; other site 716541005652 Q-loop/lid; other site 716541005653 ABC transporter signature motif; other site 716541005654 Walker B; other site 716541005655 D-loop; other site 716541005656 H-loop/switch region; other site 716541005657 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 716541005658 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716541005659 Walker A/P-loop; other site 716541005660 ATP binding site [chemical binding]; other site 716541005661 Q-loop/lid; other site 716541005662 ABC transporter signature motif; other site 716541005663 Walker B; other site 716541005664 D-loop; other site 716541005665 H-loop/switch region; other site 716541005666 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 716541005667 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 716541005668 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 716541005669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541005670 dimer interface [polypeptide binding]; other site 716541005671 conserved gate region; other site 716541005672 putative PBP binding loops; other site 716541005673 ABC-ATPase subunit interface; other site 716541005674 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168 716541005675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541005676 dimer interface [polypeptide binding]; other site 716541005677 conserved gate region; other site 716541005678 putative PBP binding loops; other site 716541005679 ABC-ATPase subunit interface; other site 716541005680 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 716541005681 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 716541005682 peptide binding site [polypeptide binding]; other site 716541005683 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 716541005684 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 716541005685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541005686 Walker A/P-loop; other site 716541005687 ATP binding site [chemical binding]; other site 716541005688 Q-loop/lid; other site 716541005689 ABC transporter signature motif; other site 716541005690 Walker B; other site 716541005691 D-loop; other site 716541005692 H-loop/switch region; other site 716541005693 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 716541005694 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541005695 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541005696 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 716541005697 Outer membrane efflux protein; Region: OEP; pfam02321 716541005698 Outer membrane efflux protein; Region: OEP; pfam02321 716541005699 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 716541005700 nucleophilic elbow; other site 716541005701 catalytic triad; other site 716541005702 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 716541005703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541005704 Walker A motif; other site 716541005705 ATP binding site [chemical binding]; other site 716541005706 Walker B motif; other site 716541005707 arginine finger; other site 716541005708 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 716541005709 phage shock protein PspA; Provisional; Region: PRK10698 716541005710 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 716541005711 phage shock protein B; Provisional; Region: pspB; PRK09458 716541005712 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 716541005713 phage shock protein C; Region: phageshock_pspC; TIGR02978 716541005714 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 716541005715 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 716541005716 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 716541005717 active site 716541005718 homodimer interface [polypeptide binding]; other site 716541005719 catalytic site [active] 716541005720 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 716541005721 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 716541005722 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 716541005723 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 716541005724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541005725 dimer interface [polypeptide binding]; other site 716541005726 conserved gate region; other site 716541005727 putative PBP binding loops; other site 716541005728 ABC-ATPase subunit interface; other site 716541005729 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 716541005730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541005731 dimer interface [polypeptide binding]; other site 716541005732 conserved gate region; other site 716541005733 putative PBP binding loops; other site 716541005734 ABC-ATPase subunit interface; other site 716541005735 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 716541005736 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 716541005737 putative NAD(P) binding site [chemical binding]; other site 716541005738 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 716541005739 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 716541005740 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 716541005741 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 716541005742 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 716541005743 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 716541005744 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 716541005745 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 716541005746 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 716541005747 beta-phosphoglucomutase; Region: bPGM; TIGR01990 716541005748 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 716541005749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541005750 motif II; other site 716541005751 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 716541005752 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 716541005753 Walker A/P-loop; other site 716541005754 ATP binding site [chemical binding]; other site 716541005755 Q-loop/lid; other site 716541005756 ABC transporter signature motif; other site 716541005757 Walker B; other site 716541005758 D-loop; other site 716541005759 H-loop/switch region; other site 716541005760 TOBE domain; Region: TOBE_2; pfam08402 716541005761 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 716541005762 Transcriptional regulators [Transcription]; Region: PurR; COG1609 716541005763 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541005764 DNA binding site [nucleotide binding] 716541005765 domain linker motif; other site 716541005766 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 716541005767 putative dimerization interface [polypeptide binding]; other site 716541005768 putative ligand binding site [chemical binding]; other site 716541005769 Predicted ATPase [General function prediction only]; Region: COG3106 716541005770 hypothetical protein; Provisional; Region: PRK05415 716541005771 Predicted membrane protein [Function unknown]; Region: COG3768 716541005772 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 716541005773 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 716541005774 putative aromatic amino acid binding site; other site 716541005775 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716541005776 putative active site [active] 716541005777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541005778 Walker A motif; other site 716541005779 ATP binding site [chemical binding]; other site 716541005780 Walker B motif; other site 716541005781 arginine finger; other site 716541005782 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 716541005783 active site 716541005784 catalytic residues [active] 716541005785 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 716541005786 dimer interface [polypeptide binding]; other site 716541005787 catalytic triad [active] 716541005788 peroxidatic and resolving cysteines [active] 716541005789 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 716541005790 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 716541005791 active site 716541005792 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 716541005793 putative active site [active] 716541005794 Zn binding site [ion binding]; other site 716541005795 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 716541005796 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 716541005797 peptide binding site [polypeptide binding]; other site 716541005798 Protein of unknown function (DUF770); Region: DUF770; pfam05591 716541005799 Protein of unknown function (DUF877); Region: DUF877; cl05484 716541005800 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 716541005801 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 716541005802 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 716541005803 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 716541005804 ligand binding site [chemical binding]; other site 716541005805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541005806 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 716541005807 Walker A motif; other site 716541005808 ATP binding site [chemical binding]; other site 716541005809 Walker B motif; other site 716541005810 arginine finger; other site 716541005811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541005812 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 716541005813 Walker A motif; other site 716541005814 ATP binding site [chemical binding]; other site 716541005815 Walker B motif; other site 716541005816 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 716541005817 virion protein; Provisional; Region: V; PHA02564 716541005818 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 716541005819 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 716541005820 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 716541005821 TIGR02594 family protein; Region: TIGR02594 716541005822 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 716541005823 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 716541005824 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 716541005825 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 716541005826 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 716541005827 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 716541005828 PAAR motif; Region: PAAR_motif; pfam05488 716541005829 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541005830 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541005831 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 716541005832 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 716541005833 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 716541005834 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 716541005835 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 716541005836 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 716541005837 ImpA domain protein; Region: DUF3702; pfam12486 716541005838 intracellular protease, PfpI family; Region: PfpI; TIGR01382 716541005839 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 716541005840 conserved cys residue [active] 716541005841 PAS domain S-box; Region: sensory_box; TIGR00229 716541005842 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716541005843 putative active site [active] 716541005844 heme pocket [chemical binding]; other site 716541005845 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541005846 metal binding site [ion binding]; metal-binding site 716541005847 active site 716541005848 I-site; other site 716541005849 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 716541005850 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 716541005851 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 716541005852 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541005853 metal binding site [ion binding]; metal-binding site 716541005854 active site 716541005855 I-site; other site 716541005856 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541005857 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 716541005858 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716541005859 dimer interface [polypeptide binding]; other site 716541005860 putative CheW interface [polypeptide binding]; other site 716541005861 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 716541005862 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 716541005863 Cl binding site [ion binding]; other site 716541005864 oligomer interface [polypeptide binding]; other site 716541005865 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 716541005866 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 716541005867 ATP binding site [chemical binding]; other site 716541005868 Mg++ binding site [ion binding]; other site 716541005869 motif III; other site 716541005870 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716541005871 nucleotide binding region [chemical binding]; other site 716541005872 ATP-binding site [chemical binding]; other site 716541005873 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 716541005874 putative RNA binding site [nucleotide binding]; other site 716541005875 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 716541005876 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 716541005877 Ligand Binding Site [chemical binding]; other site 716541005878 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 716541005879 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 716541005880 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 716541005881 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 716541005882 Walker A/P-loop; other site 716541005883 ATP binding site [chemical binding]; other site 716541005884 Q-loop/lid; other site 716541005885 ABC transporter signature motif; other site 716541005886 Walker B; other site 716541005887 D-loop; other site 716541005888 H-loop/switch region; other site 716541005889 Predicted membrane protein [Function unknown]; Region: COG3326 716541005890 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 716541005891 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 716541005892 trimer interface [polypeptide binding]; other site 716541005893 eyelet of channel; other site 716541005894 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 716541005895 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 716541005896 dimer interface [polypeptide binding]; other site 716541005897 PYR/PP interface [polypeptide binding]; other site 716541005898 TPP binding site [chemical binding]; other site 716541005899 substrate binding site [chemical binding]; other site 716541005900 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 716541005901 Domain of unknown function; Region: EKR; pfam10371 716541005902 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 716541005903 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 716541005904 TPP-binding site [chemical binding]; other site 716541005905 dimer interface [polypeptide binding]; other site 716541005906 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 716541005907 heat-inducible protein; Provisional; Region: PRK10449 716541005908 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 716541005909 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 716541005910 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 716541005911 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 716541005912 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 716541005913 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541005914 DNA-binding site [nucleotide binding]; DNA binding site 716541005915 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716541005916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541005917 homodimer interface [polypeptide binding]; other site 716541005918 catalytic residue [active] 716541005919 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 716541005920 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 716541005921 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541005922 Walker A/P-loop; other site 716541005923 ATP binding site [chemical binding]; other site 716541005924 Q-loop/lid; other site 716541005925 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 716541005926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541005927 Walker B; other site 716541005928 D-loop; other site 716541005929 H-loop/switch region; other site 716541005930 TOBE domain; Region: TOBE_2; pfam08402 716541005931 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 716541005932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541005933 dimer interface [polypeptide binding]; other site 716541005934 conserved gate region; other site 716541005935 putative PBP binding loops; other site 716541005936 ABC-ATPase subunit interface; other site 716541005937 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 716541005938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541005939 dimer interface [polypeptide binding]; other site 716541005940 conserved gate region; other site 716541005941 putative PBP binding loops; other site 716541005942 ABC-ATPase subunit interface; other site 716541005943 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 716541005944 tetrameric interface [polypeptide binding]; other site 716541005945 NAD binding site [chemical binding]; other site 716541005946 catalytic residues [active] 716541005947 substrate binding site [chemical binding]; other site 716541005948 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 716541005949 Putative lysophospholipase; Region: Hydrolase_4; cl19140 716541005950 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 716541005951 Putative bacterial virulence factor; Region: Virul_Fac; cl19867 716541005952 Virulence factor SrfB; Region: SrfB; pfam07520 716541005953 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 716541005954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 716541005955 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 716541005956 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541005957 Coenzyme A binding pocket [chemical binding]; other site 716541005958 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 716541005959 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541005960 non-specific DNA binding site [nucleotide binding]; other site 716541005961 salt bridge; other site 716541005962 sequence-specific DNA binding site [nucleotide binding]; other site 716541005963 Cupin domain; Region: Cupin_2; pfam07883 716541005964 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 716541005965 Prostaglandin dehydrogenases; Region: PGDH; cd05288 716541005966 NAD(P) binding site [chemical binding]; other site 716541005967 substrate binding site [chemical binding]; other site 716541005968 dimer interface [polypeptide binding]; other site 716541005969 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 716541005970 DNA-binding site [nucleotide binding]; DNA binding site 716541005971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 716541005972 FCD domain; Region: FCD; pfam07729 716541005973 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 716541005974 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 716541005975 N-terminal plug; other site 716541005976 ligand-binding site [chemical binding]; other site 716541005977 Uncharacterized conserved protein [Function unknown]; Region: COG3391 716541005978 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 716541005979 L-asparagine permease; Provisional; Region: PRK15049 716541005980 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 716541005981 AAA domain; Region: AAA_17; cl19128 716541005982 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 716541005983 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 716541005984 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 716541005985 metal binding site [ion binding]; metal-binding site 716541005986 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 716541005987 active site 716541005988 non-prolyl cis peptide bond; other site 716541005989 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 716541005990 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541005991 substrate binding pocket [chemical binding]; other site 716541005992 membrane-bound complex binding site; other site 716541005993 hinge residues; other site 716541005994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541005995 Coenzyme A binding pocket [chemical binding]; other site 716541005996 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 716541005997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541005998 dimer interface [polypeptide binding]; other site 716541005999 conserved gate region; other site 716541006000 putative PBP binding loops; other site 716541006001 ABC-ATPase subunit interface; other site 716541006002 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 716541006003 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 716541006004 Walker A/P-loop; other site 716541006005 ATP binding site [chemical binding]; other site 716541006006 Q-loop/lid; other site 716541006007 ABC transporter signature motif; other site 716541006008 Walker B; other site 716541006009 D-loop; other site 716541006010 H-loop/switch region; other site 716541006011 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541006012 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 716541006013 substrate binding pocket [chemical binding]; other site 716541006014 membrane-bound complex binding site; other site 716541006015 hinge residues; other site 716541006016 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 716541006017 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 716541006018 C-terminal domain interface [polypeptide binding]; other site 716541006019 GSH binding site (G-site) [chemical binding]; other site 716541006020 dimer interface [polypeptide binding]; other site 716541006021 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 716541006022 N-terminal domain interface [polypeptide binding]; other site 716541006023 dimer interface [polypeptide binding]; other site 716541006024 substrate binding pocket (H-site) [chemical binding]; other site 716541006025 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 716541006026 active site 1 [active] 716541006027 dimer interface [polypeptide binding]; other site 716541006028 hexamer interface [polypeptide binding]; other site 716541006029 active site 2 [active] 716541006030 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 716541006031 putative acyl-acceptor binding pocket; other site 716541006032 malate dehydrogenase; Provisional; Region: PRK13529 716541006033 Malic enzyme, N-terminal domain; Region: malic; pfam00390 716541006034 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 716541006035 NAD(P) binding site [chemical binding]; other site 716541006036 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 716541006037 Helix-turn-helix domain; Region: HTH_39; pfam14090 716541006038 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716541006039 dimerization interface [polypeptide binding]; other site 716541006040 putative DNA binding site [nucleotide binding]; other site 716541006041 elongation factor G; Reviewed; Region: PRK00007 716541006042 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 716541006043 G1 box; other site 716541006044 putative GEF interaction site [polypeptide binding]; other site 716541006045 GTP/Mg2+ binding site [chemical binding]; other site 716541006046 Switch I region; other site 716541006047 G2 box; other site 716541006048 G3 box; other site 716541006049 Switch II region; other site 716541006050 G4 box; other site 716541006051 G5 box; other site 716541006052 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 716541006053 Elongation Factor G, domain II; Region: EFG_II; pfam14492 716541006054 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 716541006055 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 716541006056 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 716541006057 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 716541006058 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 716541006059 catalytic triad [active] 716541006060 conserved cis-peptide bond; other site 716541006061 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 716541006062 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 716541006063 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 716541006064 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 716541006065 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 716541006066 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 716541006067 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 716541006068 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 716541006069 [4Fe-4S] binding site [ion binding]; other site 716541006070 molybdopterin cofactor binding site [chemical binding]; other site 716541006071 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 716541006072 molybdopterin cofactor binding site; other site 716541006073 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 716541006074 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 716541006075 TetR family transcriptional regulator; Provisional; Region: PRK14996 716541006076 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716541006077 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 716541006078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541006079 putative substrate translocation pore; other site 716541006080 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 716541006081 NADP+ binding site [chemical binding]; other site 716541006082 folate binding site [chemical binding]; other site 716541006083 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 716541006084 trimer interface [polypeptide binding]; other site 716541006085 eyelet of channel; other site 716541006086 aromatic amino acid exporter; Provisional; Region: PRK11689 716541006087 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 716541006088 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 716541006089 molybdopterin cofactor binding site; other site 716541006090 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 716541006091 molybdopterin cofactor binding site; other site 716541006092 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 716541006093 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 716541006094 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 716541006095 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 716541006096 CcdB protein; Region: CcdB; cl03380 716541006097 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 716541006098 MFS transport protein AraJ; Provisional; Region: PRK10091 716541006099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541006100 putative substrate translocation pore; other site 716541006101 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 716541006102 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 716541006103 NAD binding site [chemical binding]; other site 716541006104 substrate binding site [chemical binding]; other site 716541006105 catalytic Zn binding site [ion binding]; other site 716541006106 tetramer interface [polypeptide binding]; other site 716541006107 structural Zn binding site [ion binding]; other site 716541006108 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 716541006109 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716541006110 ABC transporter; Region: ABC_tran_2; pfam12848 716541006111 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716541006112 malate dehydrogenase; Provisional; Region: PRK13529 716541006113 Malic enzyme, N-terminal domain; Region: malic; pfam00390 716541006114 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 716541006115 NAD(P) binding site [chemical binding]; other site 716541006116 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 716541006117 biofilm-dependent modulation protein; Provisional; Region: PRK11436 716541006118 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 716541006119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541006120 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541006121 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 716541006122 putative effector binding pocket; other site 716541006123 dimerization interface [polypeptide binding]; other site 716541006124 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 716541006125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541006126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541006127 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 716541006128 putative effector binding pocket; other site 716541006129 putative dimerization interface [polypeptide binding]; other site 716541006130 short chain dehydrogenase; Provisional; Region: PRK06500 716541006131 classical (c) SDRs; Region: SDR_c; cd05233 716541006132 NAD(P) binding site [chemical binding]; other site 716541006133 active site 716541006134 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 716541006135 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716541006136 Walker A/P-loop; other site 716541006137 ATP binding site [chemical binding]; other site 716541006138 Q-loop/lid; other site 716541006139 ABC transporter signature motif; other site 716541006140 Walker B; other site 716541006141 D-loop; other site 716541006142 H-loop/switch region; other site 716541006143 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 716541006144 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 716541006145 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716541006146 Walker A/P-loop; other site 716541006147 ATP binding site [chemical binding]; other site 716541006148 Q-loop/lid; other site 716541006149 ABC transporter signature motif; other site 716541006150 Walker B; other site 716541006151 D-loop; other site 716541006152 H-loop/switch region; other site 716541006153 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 716541006154 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 716541006155 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 716541006156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541006157 dimer interface [polypeptide binding]; other site 716541006158 conserved gate region; other site 716541006159 putative PBP binding loops; other site 716541006160 ABC-ATPase subunit interface; other site 716541006161 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 716541006162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541006163 dimer interface [polypeptide binding]; other site 716541006164 conserved gate region; other site 716541006165 putative PBP binding loops; other site 716541006166 ABC-ATPase subunit interface; other site 716541006167 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 716541006168 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 716541006169 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 716541006170 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 716541006171 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 716541006172 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 716541006173 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 716541006174 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 716541006175 putative substrate binding site [chemical binding]; other site 716541006176 putative ATP binding site [chemical binding]; other site 716541006177 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 716541006178 maltoporin; Provisional; Region: lamB; PRK09360 716541006179 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 716541006180 trimer interface; other site 716541006181 sugar binding site [chemical binding]; other site 716541006182 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 716541006183 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 716541006184 active site turn [active] 716541006185 phosphorylation site [posttranslational modification] 716541006186 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 716541006187 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 716541006188 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 716541006189 substrate binding [chemical binding]; other site 716541006190 active site 716541006191 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 716541006192 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 716541006193 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541006194 DNA binding site [nucleotide binding] 716541006195 domain linker motif; other site 716541006196 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 716541006197 dimerization interface [polypeptide binding]; other site 716541006198 ligand binding site [chemical binding]; other site 716541006199 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 716541006200 dimer interface [polypeptide binding]; other site 716541006201 ligand binding site [chemical binding]; other site 716541006202 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541006203 dimerization interface [polypeptide binding]; other site 716541006204 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 716541006205 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716541006206 dimer interface [polypeptide binding]; other site 716541006207 putative CheW interface [polypeptide binding]; other site 716541006208 RIB43A; Region: RIB43A; pfam05914 716541006209 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 716541006210 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 716541006211 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 716541006212 DNA binding residues [nucleotide binding] 716541006213 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 716541006214 Sulfite exporter TauE/SafE; Region: TauE; cl19196 716541006215 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 716541006216 DsbD alpha interface [polypeptide binding]; other site 716541006217 catalytic residues [active] 716541006218 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 716541006219 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 716541006220 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 716541006221 catalytic residues [active] 716541006222 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 716541006223 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 716541006224 dimerization domain [polypeptide binding]; other site 716541006225 dimer interface [polypeptide binding]; other site 716541006226 catalytic residues [active] 716541006227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 716541006228 active site 716541006229 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 716541006230 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 716541006231 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541006232 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 716541006233 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 716541006234 dimerization interface [polypeptide binding]; other site 716541006235 substrate binding pocket [chemical binding]; other site 716541006236 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 716541006237 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541006238 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 716541006239 substrate binding pocket [chemical binding]; other site 716541006240 dimerization interface [polypeptide binding]; other site 716541006241 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 716541006242 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 716541006243 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 716541006244 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 716541006245 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 716541006246 catalytic site [active] 716541006247 active site 716541006248 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 716541006249 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 716541006250 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 716541006251 active site 716541006252 catalytic site [active] 716541006253 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 716541006254 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 716541006255 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 716541006256 active site 716541006257 catalytic site [active] 716541006258 MarR family; Region: MarR_2; cl17246 716541006259 Protein of unknown function (DUF969); Region: DUF969; pfam06149 716541006260 Protein of unknown function (DUF979); Region: DUF979; pfam06166 716541006261 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 716541006262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541006263 putative transporter; Provisional; Region: PRK10504 716541006264 putative substrate translocation pore; other site 716541006265 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541006266 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541006267 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 716541006268 putative substrate binding pocket [chemical binding]; other site 716541006269 putative dimerization interface [polypeptide binding]; other site 716541006270 sensor kinase CusS; Provisional; Region: PRK09835 716541006271 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541006272 dimerization interface [polypeptide binding]; other site 716541006273 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541006274 dimer interface [polypeptide binding]; other site 716541006275 phosphorylation site [posttranslational modification] 716541006276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541006277 ATP binding site [chemical binding]; other site 716541006278 Mg2+ binding site [ion binding]; other site 716541006279 G-X-G motif; other site 716541006280 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 716541006281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541006282 active site 716541006283 phosphorylation site [posttranslational modification] 716541006284 intermolecular recognition site; other site 716541006285 dimerization interface [polypeptide binding]; other site 716541006286 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541006287 DNA binding site [nucleotide binding] 716541006288 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 716541006289 Outer membrane efflux protein; Region: OEP; pfam02321 716541006290 Outer membrane efflux protein; Region: OEP; pfam02321 716541006291 periplasmic copper-binding protein; Provisional; Region: PRK09838 716541006292 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 716541006293 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541006294 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 716541006295 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 716541006296 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 716541006297 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 716541006298 Chromate transporter; Region: Chromate_transp; pfam02417 716541006299 Predicted membrane protein [Function unknown]; Region: COG4125 716541006300 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 716541006301 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 716541006302 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 716541006303 Mechanosensitive ion channel; Region: MS_channel; pfam00924 716541006304 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 716541006305 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 716541006306 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 716541006307 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 716541006308 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 716541006309 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 716541006310 dimer interface [polypeptide binding]; other site 716541006311 ADP-ribose binding site [chemical binding]; other site 716541006312 active site 716541006313 nudix motif; other site 716541006314 metal binding site [ion binding]; metal-binding site 716541006315 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 716541006316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541006317 S-adenosylmethionine binding site [chemical binding]; other site 716541006318 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 716541006319 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 716541006320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 716541006321 HAMP domain; Region: HAMP; pfam00672 716541006322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541006323 dimer interface [polypeptide binding]; other site 716541006324 phosphorylation site [posttranslational modification] 716541006325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541006326 ATP binding site [chemical binding]; other site 716541006327 Mg2+ binding site [ion binding]; other site 716541006328 G-X-G motif; other site 716541006329 osmolarity response regulator; Provisional; Region: ompR; PRK09468 716541006330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541006331 active site 716541006332 phosphorylation site [posttranslational modification] 716541006333 intermolecular recognition site; other site 716541006334 dimerization interface [polypeptide binding]; other site 716541006335 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541006336 DNA binding site [nucleotide binding] 716541006337 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 716541006338 Putative lysophospholipase; Region: Hydrolase_4; cl19140 716541006339 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 716541006340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541006341 Coenzyme A binding pocket [chemical binding]; other site 716541006342 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 716541006343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541006344 Coenzyme A binding pocket [chemical binding]; other site 716541006345 Uncharacterized protein conserved in archaea (DUF2067); Region: DUF2067; cl01288 716541006346 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 716541006347 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 716541006348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 716541006349 Predicted membrane protein [Function unknown]; Region: COG3781 716541006350 altronate oxidoreductase; Provisional; Region: PRK03643 716541006351 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 716541006352 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 716541006353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541006354 Coenzyme A binding pocket [chemical binding]; other site 716541006355 GAF domain; Region: GAF; pfam01590 716541006356 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541006357 metal binding site [ion binding]; metal-binding site 716541006358 active site 716541006359 I-site; other site 716541006360 MASE2 domain; Region: MASE2; pfam05230 716541006361 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541006362 metal binding site [ion binding]; metal-binding site 716541006363 active site 716541006364 I-site; other site 716541006365 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541006366 metal binding site [ion binding]; metal-binding site 716541006367 active site 716541006368 I-site; other site 716541006369 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 716541006370 glutaminase; Provisional; Region: PRK00971 716541006371 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 716541006372 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 716541006373 dimer interface [polypeptide binding]; other site 716541006374 ligand binding site [chemical binding]; other site 716541006375 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541006376 dimerization interface [polypeptide binding]; other site 716541006377 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 716541006378 dimer interface [polypeptide binding]; other site 716541006379 putative CheW interface [polypeptide binding]; other site 716541006380 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 716541006381 NAD(P) binding site [chemical binding]; other site 716541006382 catalytic residues [active] 716541006383 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541006384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541006385 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 716541006386 putative dimerization interface [polypeptide binding]; other site 716541006387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541006388 Coenzyme A binding pocket [chemical binding]; other site 716541006389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 716541006390 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 716541006391 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 716541006392 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 716541006393 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 716541006394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 716541006395 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 716541006396 active site 716541006397 NAD binding site [chemical binding]; other site 716541006398 metal binding site [ion binding]; metal-binding site 716541006399 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 716541006400 inhibitor site; inhibition site 716541006401 active site 716541006402 dimer interface [polypeptide binding]; other site 716541006403 catalytic residue [active] 716541006404 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 716541006405 Na binding site [ion binding]; other site 716541006406 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 716541006407 BNR repeat-like domain; Region: BNR_2; pfam13088 716541006408 Domain of unknown function (DUF386); Region: DUF386; cl01047 716541006409 short chain dehydrogenase; Provisional; Region: PRK07577 716541006410 classical (c) SDRs; Region: SDR_c; cd05233 716541006411 NAD(P) binding site [chemical binding]; other site 716541006412 active site 716541006413 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 716541006414 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 716541006415 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 716541006416 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 716541006417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541006418 putative arabinose transporter; Provisional; Region: PRK03545 716541006419 putative substrate translocation pore; other site 716541006420 inner membrane protein; Provisional; Region: PRK10995 716541006421 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 716541006422 Transcriptional regulators [Transcription]; Region: MarR; COG1846 716541006423 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 716541006424 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541006425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541006426 MarB protein; Region: MarB; pfam13999 716541006427 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 716541006428 EamA-like transporter family; Region: EamA; pfam00892 716541006429 EamA-like transporter family; Region: EamA; pfam00892 716541006430 putative transporter; Provisional; Region: PRK10054 716541006431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541006432 putative substrate translocation pore; other site 716541006433 zinc/cadmium-binding protein; Provisional; Region: PRK10306 716541006434 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 716541006435 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 716541006436 Walker A/P-loop; other site 716541006437 ATP binding site [chemical binding]; other site 716541006438 Q-loop/lid; other site 716541006439 ABC transporter signature motif; other site 716541006440 Walker B; other site 716541006441 D-loop; other site 716541006442 H-loop/switch region; other site 716541006443 Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674 716541006444 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 716541006445 Walker A/P-loop; other site 716541006446 ATP binding site [chemical binding]; other site 716541006447 Q-loop/lid; other site 716541006448 ABC transporter signature motif; other site 716541006449 Walker B; other site 716541006450 D-loop; other site 716541006451 H-loop/switch region; other site 716541006452 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 716541006453 TM-ABC transporter signature motif; other site 716541006454 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 716541006455 TM-ABC transporter signature motif; other site 716541006456 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 716541006457 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 716541006458 putative ligand binding site [chemical binding]; other site 716541006459 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 716541006460 substrate binding site [chemical binding]; other site 716541006461 THF binding site; other site 716541006462 zinc-binding site [ion binding]; other site 716541006463 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 716541006464 active site residue [active] 716541006465 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 716541006466 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 716541006467 conserved cys residue [active] 716541006468 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541006469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541006470 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 716541006471 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 716541006472 putative protease; Provisional; Region: PRK15452 716541006473 Collagenase; Region: DUF3656; pfam12392 716541006474 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 716541006475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541006476 non-specific DNA binding site [nucleotide binding]; other site 716541006477 salt bridge; other site 716541006478 sequence-specific DNA binding site [nucleotide binding]; other site 716541006479 Cupin domain; Region: Cupin_2; pfam07883 716541006480 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 716541006481 benzoate transporter; Region: benE; TIGR00843 716541006482 Helix-turn-helix domain; Region: HTH_18; pfam12833 716541006483 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541006484 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 716541006485 EamA-like transporter family; Region: EamA; pfam00892 716541006486 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 716541006487 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 716541006488 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 716541006489 peptide binding site [polypeptide binding]; other site 716541006490 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 716541006491 peptidase T-like protein; Region: PepT-like; TIGR01883 716541006492 metal binding site [ion binding]; metal-binding site 716541006493 dimer interface [polypeptide binding]; other site 716541006494 tellurite resistance protein TehB; Provisional; Region: PRK11207 716541006495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541006496 S-adenosylmethionine binding site [chemical binding]; other site 716541006497 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 716541006498 gating phenylalanine in ion channel; other site 716541006499 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 716541006500 putative trimer interface [polypeptide binding]; other site 716541006501 putative CoA binding site [chemical binding]; other site 716541006502 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 716541006503 putative trimer interface [polypeptide binding]; other site 716541006504 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 716541006505 putative trimer interface [polypeptide binding]; other site 716541006506 putative CoA binding site [chemical binding]; other site 716541006507 putative CoA binding site [chemical binding]; other site 716541006508 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 716541006509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541006510 Coenzyme A binding pocket [chemical binding]; other site 716541006511 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 716541006512 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 716541006513 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541006514 substrate binding pocket [chemical binding]; other site 716541006515 membrane-bound complex binding site; other site 716541006516 hinge residues; other site 716541006517 methionine aminotransferase; Validated; Region: PRK09082 716541006518 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716541006519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541006520 homodimer interface [polypeptide binding]; other site 716541006521 catalytic residue [active] 716541006522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541006523 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541006524 dimerization interface [polypeptide binding]; other site 716541006525 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 716541006526 substrate binding pocket [chemical binding]; other site 716541006527 catalytic triad [active] 716541006528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 716541006529 General stress protein [General function prediction only]; Region: GsiB; COG3729 716541006530 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 716541006531 dimerization interface [polypeptide binding]; other site 716541006532 metal binding site [ion binding]; metal-binding site 716541006533 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 716541006534 dinuclear metal binding motif [ion binding]; other site 716541006535 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 716541006536 dimanganese center [ion binding]; other site 716541006537 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 716541006538 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 716541006539 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 716541006540 trehalose synthase; Region: treS_nterm; TIGR02456 716541006541 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 716541006542 active site 716541006543 catalytic site [active] 716541006544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716541006545 short chain dehydrogenase; Provisional; Region: PRK07109 716541006546 NAD(P) binding site [chemical binding]; other site 716541006547 active site 716541006548 Competence-damaged protein; Region: CinA; cl00666 716541006549 Predicted membrane protein [Function unknown]; Region: COG2323 716541006550 hypothetical protein; Provisional; Region: PRK10053 716541006551 oxidoreductase; Provisional; Region: PRK07985 716541006552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716541006553 NAD(P) binding site [chemical binding]; other site 716541006554 active site 716541006555 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 716541006556 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541006557 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541006558 dimerization interface [polypeptide binding]; other site 716541006559 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; cl10513 716541006560 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 716541006561 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 716541006562 Trp docking motif [polypeptide binding]; other site 716541006563 putative active site [active] 716541006564 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 716541006565 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 716541006566 dimer interface [polypeptide binding]; other site 716541006567 ligand binding site [chemical binding]; other site 716541006568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541006569 dimerization interface [polypeptide binding]; other site 716541006570 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716541006571 dimer interface [polypeptide binding]; other site 716541006572 putative CheW interface [polypeptide binding]; other site 716541006573 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 716541006574 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 716541006575 substrate binding site [chemical binding]; other site 716541006576 catalytic Zn binding site [ion binding]; other site 716541006577 NAD binding site [chemical binding]; other site 716541006578 structural Zn binding site [ion binding]; other site 716541006579 dimer interface [polypeptide binding]; other site 716541006580 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 716541006581 putative metal binding site [ion binding]; other site 716541006582 putative homodimer interface [polypeptide binding]; other site 716541006583 putative homotetramer interface [polypeptide binding]; other site 716541006584 putative homodimer-homodimer interface [polypeptide binding]; other site 716541006585 putative allosteric switch controlling residues; other site 716541006586 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 716541006587 synthetase active site [active] 716541006588 metal binding site [ion binding]; metal-binding site 716541006589 NTP binding site [chemical binding]; other site 716541006590 Transposase; Region: HTH_Tnp_1; cl17663 716541006591 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541006592 IS2 transposase TnpB; Reviewed; Region: PRK09409 716541006593 HTH-like domain; Region: HTH_21; pfam13276 716541006594 Integrase core domain; Region: rve; pfam00665 716541006595 Integrase core domain; Region: rve_3; pfam13683 716541006596 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 716541006597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541006598 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541006599 dimerization interface [polypeptide binding]; other site 716541006600 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 716541006601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541006602 Coenzyme A binding pocket [chemical binding]; other site 716541006603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 716541006604 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 716541006605 Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases; Region: TM_EGFR-like; cd12087 716541006606 dimer interface [polypeptide binding]; other site 716541006607 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541006608 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 716541006609 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 716541006610 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541006611 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 716541006612 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 716541006613 putative active site [active] 716541006614 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 716541006615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541006616 Walker A/P-loop; other site 716541006617 ATP binding site [chemical binding]; other site 716541006618 Q-loop/lid; other site 716541006619 ABC transporter signature motif; other site 716541006620 Walker B; other site 716541006621 D-loop; other site 716541006622 H-loop/switch region; other site 716541006623 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 716541006624 Outer membrane efflux protein; Region: OEP; pfam02321 716541006625 Outer membrane efflux protein; Region: OEP; pfam02321 716541006626 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 716541006627 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 716541006628 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 716541006629 putative oxidoreductase; Provisional; Region: PRK11579 716541006630 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 716541006631 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 716541006632 cytochrome b561; Provisional; Region: PRK11513 716541006633 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 716541006634 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 716541006635 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 716541006636 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 716541006637 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 716541006638 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 716541006639 putative active site [active] 716541006640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541006641 putative substrate translocation pore; other site 716541006642 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 716541006643 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 716541006644 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541006645 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 716541006646 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541006647 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 716541006648 Outer membrane efflux protein; Region: OEP; pfam02321 716541006649 Outer membrane efflux protein; Region: OEP; pfam02321 716541006650 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 716541006651 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 716541006652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716541006653 ATP binding site [chemical binding]; other site 716541006654 putative Mg++ binding site [ion binding]; other site 716541006655 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716541006656 nucleotide binding region [chemical binding]; other site 716541006657 ATP-binding site [chemical binding]; other site 716541006658 Helicase associated domain (HA2); Region: HA2; pfam04408 716541006659 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 716541006660 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 716541006661 azoreductase; Reviewed; Region: PRK00170 716541006662 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 716541006663 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 716541006664 active site 716541006665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 716541006666 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 716541006667 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 716541006668 substrate binding site [chemical binding]; other site 716541006669 THF binding site; other site 716541006670 zinc-binding site [ion binding]; other site 716541006671 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541006672 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541006673 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 716541006674 putative effector binding pocket; other site 716541006675 dimerization interface [polypeptide binding]; other site 716541006676 Protein of unknown function, DUF606; Region: DUF606; pfam04657 716541006677 Protein of unknown function, DUF606; Region: DUF606; pfam04657 716541006678 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 716541006679 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 716541006680 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 716541006681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541006682 S-adenosylmethionine binding site [chemical binding]; other site 716541006683 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 716541006684 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 716541006685 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 716541006686 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 716541006687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716541006688 NAD(P) binding site [chemical binding]; other site 716541006689 active site 716541006690 SnoaL-like domain; Region: SnoaL_2; pfam12680 716541006691 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 716541006692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 716541006693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716541006694 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 716541006695 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 716541006696 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716541006697 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 716541006698 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 716541006699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716541006700 outer membrane protease; Reviewed; Region: PRK10993 716541006701 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 716541006702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541006703 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541006704 dimerization interface [polypeptide binding]; other site 716541006705 Uncharacterized conserved protein [Function unknown]; Region: COG1683 716541006706 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 716541006707 classical (c) SDRs; Region: SDR_c; cd05233 716541006708 NAD(P) binding site [chemical binding]; other site 716541006709 active site 716541006710 Phosphotransferase enzyme family; Region: APH; pfam01636 716541006711 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 716541006712 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 716541006713 YebG protein; Region: YebG; pfam07130 716541006714 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 716541006715 Putative lysophospholipase; Region: Hydrolase_4; cl19140 716541006716 Putative lysophospholipase; Region: Hydrolase_4; cl19140 716541006717 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 716541006718 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 716541006719 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541006720 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541006721 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 716541006722 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541006723 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541006724 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 716541006725 Protein of unknown function (DUF561); Region: DUF561; pfam04481 716541006726 Predicted transcriptional regulator [Transcription]; Region: COG1959 716541006727 Rrf2 family protein; Region: rrf2_super; TIGR00738 716541006728 HAMP domain; Region: HAMP; pfam00672 716541006729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541006730 dimer interface [polypeptide binding]; other site 716541006731 phosphorylation site [posttranslational modification] 716541006732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541006733 ATP binding site [chemical binding]; other site 716541006734 Mg2+ binding site [ion binding]; other site 716541006735 G-X-G motif; other site 716541006736 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 716541006737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541006738 active site 716541006739 phosphorylation site [posttranslational modification] 716541006740 intermolecular recognition site; other site 716541006741 dimerization interface [polypeptide binding]; other site 716541006742 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541006743 DNA binding site [nucleotide binding] 716541006744 MltA-interacting protein MipA; Region: MipA; cl01504 716541006745 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 716541006746 HTH-like domain; Region: HTH_21; pfam13276 716541006747 Integrase core domain; Region: rve; pfam00665 716541006748 Integrase core domain; Region: rve_3; pfam13683 716541006749 Transposase; Region: HTH_Tnp_1; pfam01527 716541006750 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541006751 Transposase; Region: HTH_Tnp_1; cl17663 716541006752 HTH-like domain; Region: HTH_21; pfam13276 716541006753 Integrase core domain; Region: rve; pfam00665 716541006754 Integrase core domain; Region: rve_3; pfam13683 716541006755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541006756 Transposase; Region: HTH_Tnp_1; pfam01527 716541006757 Putative lysophospholipase; Region: Hydrolase_4; cl19140 716541006758 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 716541006759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 716541006760 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 716541006761 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 716541006762 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 716541006763 putative trimer interface [polypeptide binding]; other site 716541006764 putative metal binding site [ion binding]; other site 716541006765 PaaX-like protein; Region: PaaX; pfam07848 716541006766 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 716541006767 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 716541006768 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 716541006769 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 716541006770 active site 716541006771 AMP binding site [chemical binding]; other site 716541006772 homodimer interface [polypeptide binding]; other site 716541006773 acyl-activating enzyme (AAE) consensus motif; other site 716541006774 CoA binding site [chemical binding]; other site 716541006775 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 716541006776 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 716541006777 dimer interface [polypeptide binding]; other site 716541006778 active site 716541006779 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 716541006780 CoenzymeA binding site [chemical binding]; other site 716541006781 subunit interaction site [polypeptide binding]; other site 716541006782 PHB binding site; other site 716541006783 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 716541006784 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 716541006785 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 716541006786 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 716541006787 enoyl-CoA hydratase; Provisional; Region: PRK08140 716541006788 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 716541006789 substrate binding site [chemical binding]; other site 716541006790 oxyanion hole (OAH) forming residues; other site 716541006791 trimer interface [polypeptide binding]; other site 716541006792 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 716541006793 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 716541006794 substrate binding site [chemical binding]; other site 716541006795 oxyanion hole (OAH) forming residues; other site 716541006796 trimer interface [polypeptide binding]; other site 716541006797 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 716541006798 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 716541006799 FAD binding pocket [chemical binding]; other site 716541006800 FAD binding motif [chemical binding]; other site 716541006801 phosphate binding motif [ion binding]; other site 716541006802 beta-alpha-beta structure motif; other site 716541006803 NAD(p) ribose binding residues [chemical binding]; other site 716541006804 NAD binding pocket [chemical binding]; other site 716541006805 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 716541006806 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 716541006807 catalytic loop [active] 716541006808 iron binding site [ion binding]; other site 716541006809 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 716541006810 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 716541006811 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 716541006812 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 716541006813 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 716541006814 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 716541006815 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 716541006816 substrate binding site [chemical binding]; other site 716541006817 dimer interface [polypeptide binding]; other site 716541006818 NADP binding site [chemical binding]; other site 716541006819 catalytic residues [active] 716541006820 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 716541006821 substrate binding site [chemical binding]; other site 716541006822 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 716541006823 tyramine oxidase; Provisional; Region: tynA; PRK14696 716541006824 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 716541006825 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 716541006826 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 716541006827 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 716541006828 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 716541006829 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 716541006830 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 716541006831 Alkyl sulfatase C-terminal; Region: Alkyl_sulf_C; pfam14864 716541006832 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541006833 metal binding site [ion binding]; metal-binding site 716541006834 active site 716541006835 I-site; other site 716541006836 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 716541006837 NAD(P) binding site [chemical binding]; other site 716541006838 catalytic residues [active] 716541006839 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 716541006840 AraC-binding-like domain; Region: AraC_binding_2; pfam14525 716541006841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541006842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 716541006843 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 716541006844 hypothetical protein; Provisional; Region: PRK10695 716541006845 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 716541006846 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 716541006847 putative ligand binding site [chemical binding]; other site 716541006848 putative NAD binding site [chemical binding]; other site 716541006849 catalytic site [active] 716541006850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541006851 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716541006852 putative substrate translocation pore; other site 716541006853 CHASE4 domain; Region: CHASE4; cl01308 716541006854 PAS domain; Region: PAS; smart00091 716541006855 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541006856 metal binding site [ion binding]; metal-binding site 716541006857 active site 716541006858 I-site; other site 716541006859 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541006860 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 716541006861 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 716541006862 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 716541006863 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 716541006864 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 716541006865 active site 716541006866 Zn binding site [ion binding]; other site 716541006867 malonic semialdehyde reductase; Provisional; Region: PRK10538 716541006868 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 716541006869 putative NAD(P) binding site [chemical binding]; other site 716541006870 homodimer interface [polypeptide binding]; other site 716541006871 homotetramer interface [polypeptide binding]; other site 716541006872 active site 716541006873 Transcriptional regulators [Transcription]; Region: FadR; COG2186 716541006874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541006875 DNA-binding site [nucleotide binding]; DNA binding site 716541006876 FCD domain; Region: FCD; pfam07729 716541006877 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 716541006878 Ligand Binding Site [chemical binding]; other site 716541006879 potential frameshift: common BLAST hit: gi|295697852|ref|YP_003602509.1| putative transposase 716541006880 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541006881 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 716541006882 Ligand Binding Site [chemical binding]; other site 716541006883 YdfZ protein; Region: YdfZ; pfam14001 716541006884 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 716541006885 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 716541006886 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 716541006887 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 716541006888 putative symporter YagG; Provisional; Region: PRK09669; cl15392 716541006889 glucuronate isomerase; Reviewed; Region: PRK02925 716541006890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541006891 metabolite-proton symporter; Region: 2A0106; TIGR00883 716541006892 putative substrate translocation pore; other site 716541006893 putative oxidoreductase; Provisional; Region: PRK10083 716541006894 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 716541006895 putative NAD(P) binding site [chemical binding]; other site 716541006896 catalytic Zn binding site [ion binding]; other site 716541006897 structural Zn binding site [ion binding]; other site 716541006898 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 716541006899 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 716541006900 putative active site pocket [active] 716541006901 putative metal binding site [ion binding]; other site 716541006902 hypothetical protein; Provisional; Region: PRK02237 716541006903 hypothetical protein; Provisional; Region: PRK13659 716541006904 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 716541006905 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541006906 Coenzyme A binding pocket [chemical binding]; other site 716541006907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 716541006908 lipoprotein; Reviewed; Region: PRK02939 716541006909 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 716541006910 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 716541006911 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 716541006912 putative [Fe4-S4] binding site [ion binding]; other site 716541006913 putative molybdopterin cofactor binding site [chemical binding]; other site 716541006914 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 716541006915 putative molybdopterin cofactor binding site; other site 716541006916 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 716541006917 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 716541006918 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 716541006919 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 716541006920 allophanate hydrolase; Provisional; Region: PRK08186 716541006921 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 716541006922 urea carboxylase; Region: urea_carbox; TIGR02712 716541006923 ATP-grasp domain; Region: ATP-grasp_4; cl17255 716541006924 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 716541006925 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 716541006926 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 716541006927 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 716541006928 carboxyltransferase (CT) interaction site; other site 716541006929 biotinylation site [posttranslational modification]; other site 716541006930 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 716541006931 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 716541006932 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 716541006933 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 716541006934 Walker A/P-loop; other site 716541006935 ATP binding site [chemical binding]; other site 716541006936 Q-loop/lid; other site 716541006937 ABC transporter signature motif; other site 716541006938 Walker B; other site 716541006939 D-loop; other site 716541006940 H-loop/switch region; other site 716541006941 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 716541006942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541006943 dimer interface [polypeptide binding]; other site 716541006944 conserved gate region; other site 716541006945 putative PBP binding loops; other site 716541006946 ABC-ATPase subunit interface; other site 716541006947 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 716541006948 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 716541006949 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 716541006950 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 716541006951 Uncharacterized conserved protein [Function unknown]; Region: COG5361 716541006952 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 716541006953 Uncharacterized conserved protein [Function unknown]; Region: COG5361 716541006954 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 716541006955 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 716541006956 RES domain; Region: RES; pfam08808 716541006957 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 716541006958 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 716541006959 putative C-terminal domain interface [polypeptide binding]; other site 716541006960 putative GSH binding site (G-site) [chemical binding]; other site 716541006961 putative dimer interface [polypeptide binding]; other site 716541006962 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 716541006963 N-terminal domain interface [polypeptide binding]; other site 716541006964 dimer interface [polypeptide binding]; other site 716541006965 substrate binding pocket (H-site) [chemical binding]; other site 716541006966 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 716541006967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541006968 dimer interface [polypeptide binding]; other site 716541006969 conserved gate region; other site 716541006970 putative PBP binding loops; other site 716541006971 ABC-ATPase subunit interface; other site 716541006972 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 716541006973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541006974 dimer interface [polypeptide binding]; other site 716541006975 conserved gate region; other site 716541006976 putative PBP binding loops; other site 716541006977 ABC-ATPase subunit interface; other site 716541006978 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 716541006979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541006980 Walker A/P-loop; other site 716541006981 ATP binding site [chemical binding]; other site 716541006982 Q-loop/lid; other site 716541006983 ABC transporter signature motif; other site 716541006984 Walker B; other site 716541006985 D-loop; other site 716541006986 H-loop/switch region; other site 716541006987 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 716541006988 PAAR motif; Region: PAAR_motif; pfam05488 716541006989 S-type Pyocin; Region: Pyocin_S; pfam06958 716541006990 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 716541006991 Cl- selectivity filter; other site 716541006992 Cl- binding residues [ion binding]; other site 716541006993 pore gating glutamate residue; other site 716541006994 dimer interface [polypeptide binding]; other site 716541006995 putative dithiobiotin synthetase; Provisional; Region: PRK12374 716541006996 AAA domain; Region: AAA_26; pfam13500 716541006997 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 716541006998 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 716541006999 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 716541007000 nucleotide binding site [chemical binding]; other site 716541007001 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 716541007002 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 716541007003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541007004 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 716541007005 dimerization interface [polypeptide binding]; other site 716541007006 substrate binding pocket [chemical binding]; other site 716541007007 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 716541007008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541007009 putative substrate translocation pore; other site 716541007010 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 716541007011 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 716541007012 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 716541007013 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 716541007014 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 716541007015 conserved cys residue [active] 716541007016 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 716541007017 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 716541007018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541007019 non-specific DNA binding site [nucleotide binding]; other site 716541007020 salt bridge; other site 716541007021 sequence-specific DNA binding site [nucleotide binding]; other site 716541007022 Cupin domain; Region: Cupin_2; pfam07883 716541007023 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 716541007024 NAD(P) binding site [chemical binding]; other site 716541007025 catalytic residues [active] 716541007026 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 716541007027 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 716541007028 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 716541007029 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 716541007030 inhibitor-cofactor binding pocket; inhibition site 716541007031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541007032 catalytic residue [active] 716541007033 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 716541007034 active site 716541007035 Zn binding site [ion binding]; other site 716541007036 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 716541007037 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 716541007038 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 716541007039 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 716541007040 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 716541007041 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 716541007042 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 716541007043 active site 716541007044 MltA-interacting protein MipA; Region: MipA; cl01504 716541007045 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 716541007046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541007047 active site 716541007048 phosphorylation site [posttranslational modification] 716541007049 intermolecular recognition site; other site 716541007050 dimerization interface [polypeptide binding]; other site 716541007051 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541007052 DNA binding site [nucleotide binding] 716541007053 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 716541007054 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541007055 dimer interface [polypeptide binding]; other site 716541007056 phosphorylation site [posttranslational modification] 716541007057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541007058 ATP binding site [chemical binding]; other site 716541007059 Mg2+ binding site [ion binding]; other site 716541007060 G-X-G motif; other site 716541007061 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 716541007062 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 716541007063 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541007064 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 716541007065 MMPL family; Region: MMPL; cl14618 716541007066 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 716541007067 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 716541007068 NAD(P) binding site [chemical binding]; other site 716541007069 active site 716541007070 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541007071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541007072 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 716541007073 putative effector binding pocket; other site 716541007074 dimerization interface [polypeptide binding]; other site 716541007075 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 716541007076 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 716541007077 Catalytic site [active] 716541007078 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 716541007079 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 716541007080 active site 716541007081 DNA binding site [nucleotide binding] 716541007082 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 716541007083 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 716541007084 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 716541007085 active site 716541007086 catalytic tetrad [active] 716541007087 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 716541007088 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 716541007089 dimer interface [polypeptide binding]; other site 716541007090 ligand binding site [chemical binding]; other site 716541007091 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541007092 dimerization interface [polypeptide binding]; other site 716541007093 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716541007094 dimer interface [polypeptide binding]; other site 716541007095 putative CheW interface [polypeptide binding]; other site 716541007096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 716541007097 Smr domain; Region: Smr; pfam01713 716541007098 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 716541007099 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541007100 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 716541007101 putative substrate binding pocket [chemical binding]; other site 716541007102 putative dimerization interface [polypeptide binding]; other site 716541007103 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 716541007104 amidohydrolase; Region: amidohydrolases; TIGR01891 716541007105 putative metal binding site [ion binding]; other site 716541007106 dimer interface [polypeptide binding]; other site 716541007107 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 716541007108 amidohydrolase; Region: amidohydrolases; TIGR01891 716541007109 putative metal binding site [ion binding]; other site 716541007110 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 716541007111 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 716541007112 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 716541007113 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 716541007114 DNA binding site [nucleotide binding] 716541007115 active site 716541007116 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 716541007117 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 716541007118 ligand binding site [chemical binding]; other site 716541007119 flexible hinge region; other site 716541007120 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 716541007121 putative switch regulator; other site 716541007122 non-specific DNA interactions [nucleotide binding]; other site 716541007123 DNA binding site [nucleotide binding] 716541007124 sequence specific DNA binding site [nucleotide binding]; other site 716541007125 putative cAMP binding site [chemical binding]; other site 716541007126 universal stress protein UspE; Provisional; Region: PRK11175 716541007127 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 716541007128 Ligand Binding Site [chemical binding]; other site 716541007129 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 716541007130 Ligand Binding Site [chemical binding]; other site 716541007131 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 716541007132 Mechanosensitive ion channel; Region: MS_channel; pfam00924 716541007133 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 716541007134 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 716541007135 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 716541007136 ligand binding site [chemical binding]; other site 716541007137 homodimer interface [polypeptide binding]; other site 716541007138 NAD(P) binding site [chemical binding]; other site 716541007139 trimer interface B [polypeptide binding]; other site 716541007140 trimer interface A [polypeptide binding]; other site 716541007141 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 716541007142 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 716541007143 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 716541007144 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 716541007145 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 716541007146 dihydromonapterin reductase; Provisional; Region: PRK06483 716541007147 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 716541007148 NAD(P) binding site [chemical binding]; other site 716541007149 active site 716541007150 GlpM protein; Region: GlpM; pfam06942 716541007151 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 716541007152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541007153 active site 716541007154 phosphorylation site [posttranslational modification] 716541007155 intermolecular recognition site; other site 716541007156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541007157 DNA binding site [nucleotide binding] 716541007158 sensor protein RstB; Provisional; Region: PRK10604 716541007159 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541007160 dimerization interface [polypeptide binding]; other site 716541007161 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541007162 dimer interface [polypeptide binding]; other site 716541007163 phosphorylation site [posttranslational modification] 716541007164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541007165 ATP binding site [chemical binding]; other site 716541007166 Mg2+ binding site [ion binding]; other site 716541007167 G-X-G motif; other site 716541007168 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 716541007169 fumarate hydratase; Reviewed; Region: fumC; PRK00485 716541007170 Class II fumarases; Region: Fumarase_classII; cd01362 716541007171 active site 716541007172 tetramer interface [polypeptide binding]; other site 716541007173 fumarate hydratase; Provisional; Region: PRK15389 716541007174 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 716541007175 Fumarase C-terminus; Region: Fumerase_C; pfam05683 716541007176 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 716541007177 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 716541007178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 716541007179 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 716541007180 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541007181 DNA binding site [nucleotide binding] 716541007182 domain linker motif; other site 716541007183 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 716541007184 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 716541007185 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 716541007186 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 716541007187 catalytic residues [active] 716541007188 catalytic nucleophile [active] 716541007189 Recombinase; Region: Recombinase; pfam07508 716541007190 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 716541007191 putative transposase OrfB; Reviewed; Region: PHA02517 716541007192 HTH-like domain; Region: HTH_21; pfam13276 716541007193 Integrase core domain; Region: rve; pfam00665 716541007194 Integrase core domain; Region: rve_3; pfam13683 716541007195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541007196 Transposase; Region: HTH_Tnp_1; cl17663 716541007197 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 716541007198 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 716541007199 CCC1-related family of proteins; Region: CCC1_like; cl00278 716541007200 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 716541007201 HTH-like domain; Region: HTH_21; pfam13276 716541007202 Integrase core domain; Region: rve; pfam00665 716541007203 Integrase core domain; Region: rve_3; pfam13683 716541007204 Transposase; Region: HTH_Tnp_1; cl17663 716541007205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541007206 Cytochrome b562; Region: Cytochrom_B562; cl01546 716541007207 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 716541007208 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 716541007209 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 716541007210 catalytic residues [active] 716541007211 catalytic nucleophile [active] 716541007212 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 716541007213 DNA-binding interface [nucleotide binding]; DNA binding site 716541007214 Transposase; Region: HTH_Tnp_1; cl17663 716541007215 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 716541007216 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 716541007217 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 716541007218 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 716541007219 active site turn [active] 716541007220 phosphorylation site [posttranslational modification] 716541007221 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 716541007222 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716541007223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541007224 homodimer interface [polypeptide binding]; other site 716541007225 catalytic residue [active] 716541007226 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 716541007227 active site 716541007228 purine riboside binding site [chemical binding]; other site 716541007229 putative oxidoreductase; Provisional; Region: PRK11579 716541007230 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 716541007231 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 716541007232 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541007233 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541007234 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 716541007235 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 716541007236 electron transport complex protein RsxA; Provisional; Region: PRK05151 716541007237 electron transport complex protein RnfB; Provisional; Region: PRK05113 716541007238 Putative Fe-S cluster; Region: FeS; cl17515 716541007239 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 716541007240 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 716541007241 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 716541007242 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 716541007243 SLBB domain; Region: SLBB; pfam10531 716541007244 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 716541007245 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 716541007246 electron transport complex protein RnfG; Validated; Region: PRK01908 716541007247 electron transport complex RsxE subunit; Provisional; Region: PRK12405 716541007248 endonuclease III; Provisional; Region: PRK10702 716541007249 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 716541007250 minor groove reading motif; other site 716541007251 helix-hairpin-helix signature motif; other site 716541007252 substrate binding pocket [chemical binding]; other site 716541007253 active site 716541007254 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 716541007255 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 716541007256 putative tripeptide transporter permease; Reviewed; Region: tppB; PRK09584 716541007257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541007258 putative substrate translocation pore; other site 716541007259 glutathionine S-transferase; Provisional; Region: PRK10542 716541007260 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 716541007261 C-terminal domain interface [polypeptide binding]; other site 716541007262 GSH binding site (G-site) [chemical binding]; other site 716541007263 dimer interface [polypeptide binding]; other site 716541007264 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 716541007265 N-terminal domain interface [polypeptide binding]; other site 716541007266 dimer interface [polypeptide binding]; other site 716541007267 substrate binding pocket (H-site) [chemical binding]; other site 716541007268 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 716541007269 dimer interface [polypeptide binding]; other site 716541007270 pyridoxal binding site [chemical binding]; other site 716541007271 ATP binding site [chemical binding]; other site 716541007272 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 716541007273 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 716541007274 active site 716541007275 HIGH motif; other site 716541007276 dimer interface [polypeptide binding]; other site 716541007277 KMSKS motif; other site 716541007278 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 716541007279 RNA binding surface [nucleotide binding]; other site 716541007280 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 716541007281 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 716541007282 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 716541007283 lysozyme inhibitor; Provisional; Region: PRK11372 716541007284 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 716541007285 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 716541007286 transcriptional regulator SlyA; Provisional; Region: PRK03573 716541007287 Transcriptional regulators [Transcription]; Region: MarR; COG1846 716541007288 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 716541007289 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 716541007290 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541007291 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541007292 Fusaric acid resistance protein family; Region: FUSC; pfam04632 716541007293 Fusaric acid resistance protein-like; Region: FUSC_2; cl19401 716541007294 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 716541007295 E-class dimer interface [polypeptide binding]; other site 716541007296 P-class dimer interface [polypeptide binding]; other site 716541007297 active site 716541007298 Cu2+ binding site [ion binding]; other site 716541007299 Zn2+ binding site [ion binding]; other site 716541007300 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 716541007301 active site 716541007302 catalytic tetrad [active] 716541007303 Predicted Fe-S protein [General function prediction only]; Region: COG3313 716541007304 putative metal dependent hydrolase; Provisional; Region: PRK11598 716541007305 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 716541007306 Sulfatase; Region: Sulfatase; pfam00884 716541007307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 716541007308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716541007309 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 716541007310 FMN binding site [chemical binding]; other site 716541007311 active site 716541007312 substrate binding site [chemical binding]; other site 716541007313 catalytic residue [active] 716541007314 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 716541007315 dimer interface [polypeptide binding]; other site 716541007316 active site 716541007317 metal binding site [ion binding]; metal-binding site 716541007318 glutathione binding site [chemical binding]; other site 716541007319 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 716541007320 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 716541007321 dimer interface [polypeptide binding]; other site 716541007322 catalytic site [active] 716541007323 putative active site [active] 716541007324 putative substrate binding site [chemical binding]; other site 716541007325 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 716541007326 putative GSH binding site [chemical binding]; other site 716541007327 catalytic residues [active] 716541007328 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 716541007329 NlpC/P60 family; Region: NLPC_P60; pfam00877 716541007330 superoxide dismutase; Provisional; Region: PRK10543 716541007331 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 716541007332 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 716541007333 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 716541007334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541007335 putative substrate translocation pore; other site 716541007336 hypothetical protein; Provisional; Region: PRK14756 716541007337 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 716541007338 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541007339 DNA binding site [nucleotide binding] 716541007340 domain linker motif; other site 716541007341 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 716541007342 dimerization interface [polypeptide binding]; other site 716541007343 ligand binding site [chemical binding]; other site 716541007344 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 716541007345 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541007346 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541007347 dimerization interface [polypeptide binding]; other site 716541007348 putative transporter; Provisional; Region: PRK11043 716541007349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541007350 putative substrate translocation pore; other site 716541007351 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 716541007352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541007353 S-adenosylmethionine binding site [chemical binding]; other site 716541007354 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 716541007355 Lumazine binding domain; Region: Lum_binding; pfam00677 716541007356 Lumazine binding domain; Region: Lum_binding; pfam00677 716541007357 multidrug efflux protein; Reviewed; Region: PRK01766 716541007358 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 716541007359 cation binding site [ion binding]; other site 716541007360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 716541007361 hypothetical protein; Provisional; Region: PRK09897 716541007362 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 716541007363 active site clefts [active] 716541007364 zinc binding site [ion binding]; other site 716541007365 dimer interface [polypeptide binding]; other site 716541007366 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 716541007367 Domain of unknown function (DUF336); Region: DUF336; cl01249 716541007368 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 716541007369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541007370 active site 716541007371 phosphorylation site [posttranslational modification] 716541007372 intermolecular recognition site; other site 716541007373 dimerization interface [polypeptide binding]; other site 716541007374 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541007375 DNA binding residues [nucleotide binding] 716541007376 dimerization interface [polypeptide binding]; other site 716541007377 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 716541007378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541007379 dimer interface [polypeptide binding]; other site 716541007380 phosphorylation site [posttranslational modification] 716541007381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541007382 ATP binding site [chemical binding]; other site 716541007383 Mg2+ binding site [ion binding]; other site 716541007384 G-X-G motif; other site 716541007385 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 716541007386 hypothetical protein; Provisional; Region: PRK10292 716541007387 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 716541007388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541007389 dimer interface [polypeptide binding]; other site 716541007390 conserved gate region; other site 716541007391 putative PBP binding loops; other site 716541007392 ABC-ATPase subunit interface; other site 716541007393 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 716541007394 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 716541007395 Walker A/P-loop; other site 716541007396 ATP binding site [chemical binding]; other site 716541007397 Q-loop/lid; other site 716541007398 ABC transporter signature motif; other site 716541007399 Walker B; other site 716541007400 D-loop; other site 716541007401 H-loop/switch region; other site 716541007402 NIL domain; Region: NIL; pfam09383 716541007403 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 716541007404 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 716541007405 dimer interface [polypeptide binding]; other site 716541007406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541007407 catalytic residue [active] 716541007408 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 716541007409 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 716541007410 homodimer interface [polypeptide binding]; other site 716541007411 substrate-cofactor binding pocket; other site 716541007412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541007413 catalytic residue [active] 716541007414 pyruvate kinase; Provisional; Region: PRK09206 716541007415 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 716541007416 domain interfaces; other site 716541007417 active site 716541007418 murein lipoprotein; Provisional; Region: PRK15396 716541007419 L,D-transpeptidase; Provisional; Region: PRK10260 716541007420 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 716541007421 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 716541007422 cysteine desufuration protein SufE; Provisional; Region: PRK09296 716541007423 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 716541007424 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 716541007425 catalytic residue [active] 716541007426 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 716541007427 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 716541007428 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 716541007429 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 716541007430 Walker A/P-loop; other site 716541007431 ATP binding site [chemical binding]; other site 716541007432 Q-loop/lid; other site 716541007433 ABC transporter signature motif; other site 716541007434 Walker B; other site 716541007435 D-loop; other site 716541007436 H-loop/switch region; other site 716541007437 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 716541007438 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 716541007439 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 716541007440 transcriptional regulator MirA; Provisional; Region: PRK15043 716541007441 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 716541007442 DNA binding residues [nucleotide binding] 716541007443 Sensors of blue-light using FAD; Region: BLUF; smart01034 716541007444 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541007445 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 716541007446 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 716541007447 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 716541007448 [4Fe-4S] binding site [ion binding]; other site 716541007449 molybdopterin cofactor binding site; other site 716541007450 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 716541007451 molybdopterin cofactor binding site; other site 716541007452 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 716541007453 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541007454 DNA binding residues [nucleotide binding] 716541007455 dimerization interface [polypeptide binding]; other site 716541007456 Fimbrial protein; Region: Fimbrial; cl01416 716541007457 Fimbrial protein; Region: Fimbrial; cl01416 716541007458 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 716541007459 PapC N-terminal domain; Region: PapC_N; pfam13954 716541007460 Outer membrane usher protein; Region: Usher; pfam00577 716541007461 PapC C-terminal domain; Region: PapC_C; pfam13953 716541007462 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 716541007463 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 716541007464 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 716541007465 Fimbrial protein; Region: Fimbrial; cl01416 716541007466 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 716541007467 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 716541007468 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 716541007469 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 716541007470 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 716541007471 CoenzymeA binding site [chemical binding]; other site 716541007472 subunit interaction site [polypeptide binding]; other site 716541007473 PHB binding site; other site 716541007474 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 716541007475 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 716541007476 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 716541007477 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 716541007478 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 716541007479 FAD binding domain; Region: FAD_binding_4; pfam01565 716541007480 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 716541007481 putative inner membrane protein; Provisional; Region: PRK10983 716541007482 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 716541007483 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 716541007484 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 716541007485 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 716541007486 putative symporter YagG; Provisional; Region: PRK09669 716541007487 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 716541007488 phosphoenolpyruvate synthase; Validated; Region: PRK06464 716541007489 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 716541007490 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 716541007491 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 716541007492 PEP synthetase regulatory protein; Provisional; Region: PRK05339 716541007493 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 716541007494 hypothetical protein; Provisional; Region: PRK10183 716541007495 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 716541007496 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 716541007497 N-terminal plug; other site 716541007498 ligand-binding site [chemical binding]; other site 716541007499 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 716541007500 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 716541007501 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 716541007502 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 716541007503 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 716541007504 putative hemin binding site; other site 716541007505 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716541007506 ABC-ATPase subunit interface; other site 716541007507 dimer interface [polypeptide binding]; other site 716541007508 putative PBP binding regions; other site 716541007509 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 716541007510 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 716541007511 Walker A/P-loop; other site 716541007512 ATP binding site [chemical binding]; other site 716541007513 Q-loop/lid; other site 716541007514 ABC transporter signature motif; other site 716541007515 Walker B; other site 716541007516 D-loop; other site 716541007517 H-loop/switch region; other site 716541007518 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541007519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541007520 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 716541007521 putative dimerization interface [polypeptide binding]; other site 716541007522 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 716541007523 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 716541007524 putative acyltransferase; Provisional; Region: PRK05790 716541007525 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 716541007526 dimer interface [polypeptide binding]; other site 716541007527 active site 716541007528 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 716541007529 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 716541007530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716541007531 NAD(P) binding site [chemical binding]; other site 716541007532 active site 716541007533 hypothetical protein; Validated; Region: PRK00029 716541007534 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 716541007535 NlpC/P60 family; Region: NLPC_P60; pfam00877 716541007536 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 716541007537 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 716541007538 Walker A/P-loop; other site 716541007539 ATP binding site [chemical binding]; other site 716541007540 Q-loop/lid; other site 716541007541 ABC transporter signature motif; other site 716541007542 Walker B; other site 716541007543 D-loop; other site 716541007544 H-loop/switch region; other site 716541007545 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 716541007546 catalytic residues [active] 716541007547 dimer interface [polypeptide binding]; other site 716541007548 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716541007549 dimer interface [polypeptide binding]; other site 716541007550 putative PBP binding regions; other site 716541007551 ABC-ATPase subunit interface; other site 716541007552 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 716541007553 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 716541007554 DNA binding site [nucleotide binding] 716541007555 dimer interface [polypeptide binding]; other site 716541007556 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 716541007557 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 716541007558 putative tRNA-binding site [nucleotide binding]; other site 716541007559 B3/4 domain; Region: B3_4; pfam03483 716541007560 tRNA synthetase B5 domain; Region: B5; smart00874 716541007561 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 716541007562 dimer interface [polypeptide binding]; other site 716541007563 motif 1; other site 716541007564 motif 3; other site 716541007565 motif 2; other site 716541007566 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 716541007567 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 716541007568 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 716541007569 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 716541007570 dimer interface [polypeptide binding]; other site 716541007571 motif 1; other site 716541007572 active site 716541007573 motif 2; other site 716541007574 motif 3; other site 716541007575 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 716541007576 23S rRNA binding site [nucleotide binding]; other site 716541007577 L21 binding site [polypeptide binding]; other site 716541007578 L13 binding site [polypeptide binding]; other site 716541007579 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 716541007580 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 716541007581 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 716541007582 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 716541007583 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 716541007584 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 716541007585 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 716541007586 active site 716541007587 dimer interface [polypeptide binding]; other site 716541007588 motif 1; other site 716541007589 motif 2; other site 716541007590 motif 3; other site 716541007591 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 716541007592 anticodon binding site; other site 716541007593 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 716541007594 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 716541007595 putative substrate binding site [chemical binding]; other site 716541007596 putative ATP binding site [chemical binding]; other site 716541007597 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 716541007598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001 716541007599 Phosphotransferase enzyme family; Region: APH; pfam01636 716541007600 YniB-like protein; Region: YniB; pfam14002 716541007601 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 716541007602 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541007603 active site 716541007604 motif I; other site 716541007605 motif II; other site 716541007606 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 716541007607 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 716541007608 NADP binding site [chemical binding]; other site 716541007609 homodimer interface [polypeptide binding]; other site 716541007610 active site 716541007611 inner membrane protein; Provisional; Region: PRK11648 716541007612 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 716541007613 cell division modulator; Provisional; Region: PRK10113 716541007614 hydroperoxidase II; Provisional; Region: katE; PRK11249 716541007615 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 716541007616 tetramer interface [polypeptide binding]; other site 716541007617 heme binding pocket [chemical binding]; other site 716541007618 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 716541007619 domain interactions; other site 716541007620 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 716541007621 putative active site [active] 716541007622 YdjC motif; other site 716541007623 Mg binding site [ion binding]; other site 716541007624 putative homodimer interface [polypeptide binding]; other site 716541007625 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 716541007626 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 716541007627 NAD binding site [chemical binding]; other site 716541007628 sugar binding site [chemical binding]; other site 716541007629 divalent metal binding site [ion binding]; other site 716541007630 tetramer (dimer of dimers) interface [polypeptide binding]; other site 716541007631 dimer interface [polypeptide binding]; other site 716541007632 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 716541007633 Cupin domain; Region: Cupin_2; cl17218 716541007634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541007635 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 716541007636 methionine cluster; other site 716541007637 active site 716541007638 phosphorylation site [posttranslational modification] 716541007639 metal binding site [ion binding]; metal-binding site 716541007640 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 716541007641 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 716541007642 active site 716541007643 P-loop; other site 716541007644 phosphorylation site [posttranslational modification] 716541007645 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 716541007646 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 716541007647 homodimer interface [polypeptide binding]; other site 716541007648 NAD binding pocket [chemical binding]; other site 716541007649 ATP binding pocket [chemical binding]; other site 716541007650 Mg binding site [ion binding]; other site 716541007651 active-site loop [active] 716541007652 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 716541007653 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 716541007654 GIY-YIG motif/motif A; other site 716541007655 active site 716541007656 catalytic site [active] 716541007657 putative DNA binding site [nucleotide binding]; other site 716541007658 metal binding site [ion binding]; metal-binding site 716541007659 hypothetical protein; Provisional; Region: PRK11396 716541007660 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 716541007661 dimer interface [polypeptide binding]; other site 716541007662 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 716541007663 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 716541007664 putative active site [active] 716541007665 Zn binding site [ion binding]; other site 716541007666 succinylarginine dihydrolase; Provisional; Region: PRK13281 716541007667 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 716541007668 NAD(P) binding site [chemical binding]; other site 716541007669 catalytic residues [active] 716541007670 arginine succinyltransferase; Provisional; Region: PRK10456 716541007671 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 716541007672 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 716541007673 inhibitor-cofactor binding pocket; inhibition site 716541007674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541007675 catalytic residue [active] 716541007676 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 716541007677 putative catalytic site [active] 716541007678 putative phosphate binding site [ion binding]; other site 716541007679 active site 716541007680 metal binding site A [ion binding]; metal-binding site 716541007681 DNA binding site [nucleotide binding] 716541007682 putative AP binding site [nucleotide binding]; other site 716541007683 putative metal binding site B [ion binding]; other site 716541007684 Uncharacterized conserved protein [Function unknown]; Region: COG0398 716541007685 hypothetical protein; Provisional; Region: PRK11622 716541007686 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 716541007687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541007688 dimer interface [polypeptide binding]; other site 716541007689 conserved gate region; other site 716541007690 putative PBP binding loops; other site 716541007691 ABC-ATPase subunit interface; other site 716541007692 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 716541007693 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541007694 Walker A/P-loop; other site 716541007695 ATP binding site [chemical binding]; other site 716541007696 Q-loop/lid; other site 716541007697 ABC transporter signature motif; other site 716541007698 Walker B; other site 716541007699 D-loop; other site 716541007700 H-loop/switch region; other site 716541007701 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 716541007702 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 716541007703 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 716541007704 active site residue [active] 716541007705 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 716541007706 active site residue [active] 716541007707 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 716541007708 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 716541007709 Uncharacterized conserved protein [Function unknown]; Region: COG2128 716541007710 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 716541007711 active site 716541007712 8-oxo-dGMP binding site [chemical binding]; other site 716541007713 nudix motif; other site 716541007714 metal binding site [ion binding]; metal-binding site 716541007715 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 716541007716 glutamate dehydrogenase; Provisional; Region: PRK09414 716541007717 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 716541007718 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 716541007719 NAD(P) binding site [chemical binding]; other site 716541007720 DNA topoisomerase III; Provisional; Region: PRK07726 716541007721 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 716541007722 active site 716541007723 putative interdomain interaction site [polypeptide binding]; other site 716541007724 putative metal-binding site [ion binding]; other site 716541007725 putative nucleotide binding site [chemical binding]; other site 716541007726 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 716541007727 domain I; other site 716541007728 DNA binding groove [nucleotide binding] 716541007729 phosphate binding site [ion binding]; other site 716541007730 domain II; other site 716541007731 domain III; other site 716541007732 nucleotide binding site [chemical binding]; other site 716541007733 catalytic site [active] 716541007734 domain IV; other site 716541007735 selenophosphate synthetase; Provisional; Region: PRK00943 716541007736 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 716541007737 dimerization interface [polypeptide binding]; other site 716541007738 putative ATP binding site [chemical binding]; other site 716541007739 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 716541007740 putative FMN binding site [chemical binding]; other site 716541007741 protease 4; Provisional; Region: PRK10949 716541007742 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 716541007743 tandem repeat interface [polypeptide binding]; other site 716541007744 oligomer interface [polypeptide binding]; other site 716541007745 active site residues [active] 716541007746 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 716541007747 tandem repeat interface [polypeptide binding]; other site 716541007748 oligomer interface [polypeptide binding]; other site 716541007749 active site residues [active] 716541007750 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 716541007751 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 716541007752 active site 716541007753 homodimer interface [polypeptide binding]; other site 716541007754 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 716541007755 catalytic triad [active] 716541007756 metal binding site [ion binding]; metal-binding site 716541007757 conserved cis-peptide bond; other site 716541007758 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 716541007759 Glyco_18 domain; Region: Glyco_18; smart00636 716541007760 active site 716541007761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 716541007762 methionine sulfoxide reductase B; Provisional; Region: PRK00222 716541007763 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 716541007764 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 716541007765 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 716541007766 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 716541007767 active site 716541007768 phosphate binding residues; other site 716541007769 catalytic residues [active] 716541007770 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 716541007771 Transposase; Region: HTH_Tnp_1; pfam01527 716541007772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 716541007773 HTH-like domain; Region: HTH_21; pfam13276 716541007774 Integrase core domain; Region: rve; pfam00665 716541007775 Integrase core domain; Region: rve_3; pfam13683 716541007776 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 716541007777 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 716541007778 catalytic residues [active] 716541007779 catalytic nucleophile [active] 716541007780 Recombinase; Region: Recombinase; pfam07508 716541007781 Recombinase; Region: Recombinase; pfam07508 716541007782 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 716541007783 PrkA family serine protein kinase; Provisional; Region: PRK15455 716541007784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541007785 Walker A motif; other site 716541007786 ATP binding site [chemical binding]; other site 716541007787 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 716541007788 Uncharacterized conserved protein [Function unknown]; Region: COG2718 716541007789 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 716541007790 putative deacylase active site [active] 716541007791 Predicted membrane protein [Function unknown]; Region: COG2707 716541007792 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 716541007793 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 716541007794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541007795 putative substrate translocation pore; other site 716541007796 hypothetical protein; Validated; Region: PRK06186 716541007797 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 716541007798 conserved cys residue [active] 716541007799 Uncharacterized conserved protein [Function unknown]; Region: COG3189 716541007800 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 716541007801 Domain of unknown function (DUF333); Region: DUF333; pfam03891 716541007802 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 716541007803 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541007804 metal binding site [ion binding]; metal-binding site 716541007805 active site 716541007806 I-site; other site 716541007807 hypothetical protein; Provisional; Region: PRK10457 716541007808 Cache domain; Region: Cache_1; pfam02743 716541007809 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541007810 metal binding site [ion binding]; metal-binding site 716541007811 active site 716541007812 I-site; other site 716541007813 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 716541007814 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 716541007815 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541007816 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 716541007817 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 716541007818 BCCT family transporter; Region: BCCT; cl00569 716541007819 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 716541007820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541007821 active site 716541007822 phosphorylation site [posttranslational modification] 716541007823 intermolecular recognition site; other site 716541007824 dimerization interface [polypeptide binding]; other site 716541007825 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541007826 DNA binding residues [nucleotide binding] 716541007827 dimerization interface [polypeptide binding]; other site 716541007828 isocitrate dehydrogenase; Reviewed; Region: PRK07006 716541007829 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 716541007830 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 716541007831 probable active site [active] 716541007832 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 716541007833 nudix motif; other site 716541007834 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 716541007835 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 716541007836 Ligand Binding Site [chemical binding]; other site 716541007837 putative lysogenization regulator; Reviewed; Region: PRK00218 716541007838 adenylosuccinate lyase; Provisional; Region: PRK09285 716541007839 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 716541007840 tetramer interface [polypeptide binding]; other site 716541007841 active site 716541007842 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 716541007843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541007844 active site 716541007845 phosphorylation site [posttranslational modification] 716541007846 intermolecular recognition site; other site 716541007847 dimerization interface [polypeptide binding]; other site 716541007848 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541007849 DNA binding site [nucleotide binding] 716541007850 sensor protein PhoQ; Provisional; Region: PRK10815 716541007851 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 716541007852 HAMP domain; Region: HAMP; pfam00672 716541007853 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 716541007854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541007855 ATP binding site [chemical binding]; other site 716541007856 Mg2+ binding site [ion binding]; other site 716541007857 G-X-G motif; other site 716541007858 Uncharacterized conserved protein [Function unknown]; Region: COG2850 716541007859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 716541007860 peptidase T-like protein; Region: PepT-like; TIGR01883 716541007861 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 716541007862 metal binding site [ion binding]; metal-binding site 716541007863 dimer interface [polypeptide binding]; other site 716541007864 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 716541007865 Transposase; Region: DEDD_Tnp_IS110; pfam01548 716541007866 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 716541007867 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 716541007868 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 716541007869 Walker A/P-loop; other site 716541007870 ATP binding site [chemical binding]; other site 716541007871 Q-loop/lid; other site 716541007872 ABC transporter signature motif; other site 716541007873 Walker B; other site 716541007874 D-loop; other site 716541007875 H-loop/switch region; other site 716541007876 TOBE domain; Region: TOBE_2; pfam08402 716541007877 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 716541007878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541007879 dimer interface [polypeptide binding]; other site 716541007880 conserved gate region; other site 716541007881 putative PBP binding loops; other site 716541007882 ABC-ATPase subunit interface; other site 716541007883 spermidine/putrescine ABC transporter membrane protein; Reviewed; Region: potC; PRK09500 716541007884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541007885 dimer interface [polypeptide binding]; other site 716541007886 conserved gate region; other site 716541007887 putative PBP binding loops; other site 716541007888 ABC-ATPase subunit interface; other site 716541007889 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 716541007890 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 716541007891 EAL domain; Region: EAL; pfam00563 716541007892 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 716541007893 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 716541007894 NAD+ binding site [chemical binding]; other site 716541007895 substrate binding site [chemical binding]; other site 716541007896 Zn binding site [ion binding]; other site 716541007897 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 716541007898 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 716541007899 nucleotide binding site [chemical binding]; other site 716541007900 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 716541007901 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 716541007902 FtsX-like permease family; Region: FtsX; pfam02687 716541007903 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 716541007904 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 716541007905 Walker A/P-loop; other site 716541007906 ATP binding site [chemical binding]; other site 716541007907 Q-loop/lid; other site 716541007908 ABC transporter signature motif; other site 716541007909 Walker B; other site 716541007910 D-loop; other site 716541007911 H-loop/switch region; other site 716541007912 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 716541007913 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 716541007914 FtsX-like permease family; Region: FtsX; pfam02687 716541007915 Predicted membrane protein [Function unknown]; Region: COG4763 716541007916 transcription-repair coupling factor; Provisional; Region: PRK10689 716541007917 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 716541007918 DNA polymerase phi; Region: DNA_pol_phi; pfam04931 716541007919 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 716541007920 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716541007921 ATP binding site [chemical binding]; other site 716541007922 putative Mg++ binding site [ion binding]; other site 716541007923 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716541007924 nucleotide binding region [chemical binding]; other site 716541007925 ATP-binding site [chemical binding]; other site 716541007926 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 716541007927 L,D-transpeptidase; Provisional; Region: PRK10260 716541007928 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 716541007929 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 716541007930 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 716541007931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 716541007932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716541007933 hypothetical protein; Provisional; Region: PRK11280 716541007934 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 716541007935 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716541007936 hypothetical protein; Provisional; Region: PRK04940 716541007937 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 716541007938 beta-hexosaminidase; Provisional; Region: PRK05337 716541007939 Phosphotransferase enzyme family; Region: APH; pfam01636 716541007940 thiamine kinase; Provisional; Region: thiK; PRK10271 716541007941 active site 716541007942 ATP binding site [chemical binding]; other site 716541007943 substrate binding site [chemical binding]; other site 716541007944 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 716541007945 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 716541007946 putative dimer interface [polypeptide binding]; other site 716541007947 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 716541007948 nucleotide binding site/active site [active] 716541007949 HIT family signature motif; other site 716541007950 catalytic residue [active] 716541007951 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 716541007952 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 716541007953 N-terminal plug; other site 716541007954 ligand-binding site [chemical binding]; other site 716541007955 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 716541007956 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 716541007957 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 716541007958 active site turn [active] 716541007959 phosphorylation site [posttranslational modification] 716541007960 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 716541007961 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 716541007962 active site 716541007963 DNA polymerase III subunit delta'; Validated; Region: PRK07993 716541007964 DNA polymerase III subunit delta'; Validated; Region: PRK08485 716541007965 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 716541007966 thymidylate kinase; Validated; Region: tmk; PRK00698 716541007967 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 716541007968 TMP-binding site; other site 716541007969 ATP-binding site [chemical binding]; other site 716541007970 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 716541007971 dimerization interface [polypeptide binding]; other site 716541007972 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 716541007973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541007974 catalytic residue [active] 716541007975 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 716541007976 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 716541007977 dimer interface [polypeptide binding]; other site 716541007978 active site 716541007979 acyl carrier protein; Provisional; Region: acpP; PRK00982 716541007980 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 716541007981 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 716541007982 NAD(P) binding site [chemical binding]; other site 716541007983 homotetramer interface [polypeptide binding]; other site 716541007984 homodimer interface [polypeptide binding]; other site 716541007985 active site 716541007986 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 716541007987 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 716541007988 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 716541007989 dimer interface [polypeptide binding]; other site 716541007990 active site 716541007991 CoA binding pocket [chemical binding]; other site 716541007992 putative phosphate acyltransferase; Provisional; Region: PRK05331 716541007993 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 716541007994 hypothetical protein; Provisional; Region: PRK11193 716541007995 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 716541007996 active site 716541007997 dimer interface [polypeptide binding]; other site 716541007998 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 716541007999 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 716541008000 RNA binding surface [nucleotide binding]; other site 716541008001 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 716541008002 active site 716541008003 ribonuclease E; Reviewed; Region: rne; PRK10811 716541008004 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 716541008005 homodimer interface [polypeptide binding]; other site 716541008006 oligonucleotide binding site [chemical binding]; other site 716541008007 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 716541008008 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 716541008009 transcriptional activator TtdR; Provisional; Region: PRK09801 716541008010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541008011 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 716541008012 putative effector binding pocket; other site 716541008013 dimerization interface [polypeptide binding]; other site 716541008014 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 716541008015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541008016 putative substrate translocation pore; other site 716541008017 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 716541008018 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 716541008019 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 716541008020 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 716541008021 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 716541008022 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 716541008023 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 716541008024 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 716541008025 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 716541008026 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 716541008027 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 716541008028 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 716541008029 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 716541008030 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 716541008031 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 716541008032 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 716541008033 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 716541008034 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 716541008035 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 716541008036 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 716541008037 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 716541008038 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 716541008039 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 716541008040 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 716541008041 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 716541008042 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 716541008043 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 716541008044 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 716541008045 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 716541008046 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 716541008047 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 716541008048 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 716541008049 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 716541008050 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 716541008051 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 716541008052 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 716541008053 hypothetical protein; Provisional; Region: PRK11239 716541008054 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 716541008055 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 716541008056 multidrug resistance protein MdtH; Provisional; Region: PRK11646 716541008057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541008058 putative substrate translocation pore; other site 716541008059 lipoprotein; Provisional; Region: PRK10598 716541008060 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 716541008061 active site 716541008062 substrate binding pocket [chemical binding]; other site 716541008063 dimer interface [polypeptide binding]; other site 716541008064 DinI-like family; Region: DinI; cl11630 716541008065 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 716541008066 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 716541008067 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 716541008068 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 716541008069 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 716541008070 hypothetical protein; Provisional; Region: PRK03757 716541008071 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 716541008072 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 716541008073 active site residue [active] 716541008074 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 716541008075 putative acyl-acceptor binding pocket; other site 716541008076 drug efflux system protein MdtG; Provisional; Region: PRK09874 716541008077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541008078 putative substrate translocation pore; other site 716541008079 Transposase; Region: HTH_Tnp_1; pfam01527 716541008080 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 716541008081 HTH-like domain; Region: HTH_21; pfam13276 716541008082 Integrase core domain; Region: rve; pfam00665 716541008083 Integrase core domain; Region: rve_3; pfam13683 716541008084 secY/secA suppressor protein; Provisional; Region: PRK11467 716541008085 lipoprotein; Provisional; Region: PRK10175 716541008086 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 716541008087 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 716541008088 Ligand binding site; other site 716541008089 DXD motif; other site 716541008090 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 716541008091 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 716541008092 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 716541008093 putative ADP-ribose binding site [chemical binding]; other site 716541008094 putative active site [active] 716541008095 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 716541008096 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 716541008097 major curlin subunit; Provisional; Region: csgA; PRK10051 716541008098 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 716541008099 major curlin subunit; Provisional; Region: csgA; PRK10051 716541008100 Curlin associated repeat; Region: Curlin_rpt; pfam07012 716541008101 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 716541008102 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541008103 DNA binding residues [nucleotide binding] 716541008104 dimerization interface [polypeptide binding]; other site 716541008105 curli assembly protein CsgE; Provisional; Region: PRK10386 716541008106 curli assembly protein CsgF; Provisional; Region: PRK10050 716541008107 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 716541008108 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 716541008109 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 716541008110 putative hydrolase; Validated; Region: PRK09248 716541008111 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 716541008112 active site 716541008113 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 716541008114 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 716541008115 putative ligand binding site [chemical binding]; other site 716541008116 NAD binding site [chemical binding]; other site 716541008117 dimerization interface [polypeptide binding]; other site 716541008118 catalytic site [active] 716541008119 LysR family transcriptional regulator; Provisional; Region: PRK14997 716541008120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541008121 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 716541008122 putative effector binding pocket; other site 716541008123 putative dimerization interface [polypeptide binding]; other site 716541008124 Pirin-related protein [General function prediction only]; Region: COG1741 716541008125 Pirin; Region: Pirin; pfam02678 716541008126 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 716541008127 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 716541008128 catalytic triad [active] 716541008129 conserved cis-peptide bond; other site 716541008130 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 716541008131 hypothetical protein; Provisional; Region: PRK10536 716541008132 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 716541008133 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 716541008134 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 716541008135 Uncharacterized subfamiy of Cupredoxin; Region: Cupredoxin_like_3; cd04203 716541008136 Type 1 (T1) Cu binding site [ion binding]; other site 716541008137 Imelysin; Region: Peptidase_M75; pfam09375 716541008138 FTR1 family protein; Region: TIGR00145 716541008139 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 716541008140 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 716541008141 Nucleoside recognition; Region: Gate; pfam07670 716541008142 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 716541008143 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 716541008144 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 716541008145 Na binding site [ion binding]; other site 716541008146 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 716541008147 Predicted transcriptional regulator [Transcription]; Region: COG3905 716541008148 DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850 716541008149 Proline dehydrogenase; Region: Pro_dh; pfam01619 716541008150 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 716541008151 Glutamate binding site [chemical binding]; other site 716541008152 NAD binding site [chemical binding]; other site 716541008153 catalytic residues [active] 716541008154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 716541008155 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 716541008156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716541008157 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 716541008158 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 716541008159 active site 716541008160 dimer interface [polypeptide binding]; other site 716541008161 non-prolyl cis peptide bond; other site 716541008162 insertion regions; other site 716541008163 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 716541008164 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 716541008165 catalytic triad [active] 716541008166 conserved cis-peptide bond; other site 716541008167 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 716541008168 homotrimer interaction site [polypeptide binding]; other site 716541008169 putative active site [active] 716541008170 pyrimidine utilization protein D; Region: RutD; TIGR03611 716541008171 Putative lysophospholipase; Region: Hydrolase_4; cl19140 716541008172 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 716541008173 putative FMN binding site [chemical binding]; other site 716541008174 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 716541008175 Sulfate transporter family; Region: Sulfate_transp; cl19250 716541008176 uracil-xanthine permease; Region: ncs2; TIGR00801 716541008177 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 716541008178 EamA-like transporter family; Region: EamA; pfam00892 716541008179 General stress protein [General function prediction only]; Region: GsiB; COG3729 716541008180 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 716541008181 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 716541008182 hypothetical protein; Provisional; Region: PRK10174 716541008183 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 716541008184 catalytic core [active] 716541008185 Predicted transcriptional regulators [Transcription]; Region: COG1733 716541008186 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 716541008187 classical (c) SDRs; Region: SDR_c; cd05233 716541008188 NAD(P) binding site [chemical binding]; other site 716541008189 active site 716541008190 Predicted transcriptional regulators [Transcription]; Region: COG1733 716541008191 short chain dehydrogenase; Provisional; Region: PRK06500 716541008192 classical (c) SDRs; Region: SDR_c; cd05233 716541008193 NAD(P) binding site [chemical binding]; other site 716541008194 active site 716541008195 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 716541008196 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 716541008197 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 716541008198 Divalent cation transporter; Region: MgtE; pfam01769 716541008199 lac repressor; Reviewed; Region: lacI; PRK09526 716541008200 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541008201 DNA binding site [nucleotide binding] 716541008202 domain linker motif; other site 716541008203 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 716541008204 ligand binding site [chemical binding]; other site 716541008205 dimerization interface (open form) [polypeptide binding]; other site 716541008206 dimerization interface (closed form) [polypeptide binding]; other site 716541008207 maltoporin; Provisional; Region: lamB; PRK09360 716541008208 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 716541008209 trimer interface; other site 716541008210 sugar binding site [chemical binding]; other site 716541008211 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 716541008212 active site turn [active] 716541008213 phosphorylation site [posttranslational modification] 716541008214 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 716541008215 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 716541008216 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 716541008217 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 716541008218 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 716541008219 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 716541008220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541008221 dimer interface [polypeptide binding]; other site 716541008222 conserved gate region; other site 716541008223 putative PBP binding loops; other site 716541008224 ABC-ATPase subunit interface; other site 716541008225 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 716541008226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541008227 dimer interface [polypeptide binding]; other site 716541008228 conserved gate region; other site 716541008229 putative PBP binding loops; other site 716541008230 ABC-ATPase subunit interface; other site 716541008231 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 716541008232 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 716541008233 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 716541008234 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 716541008235 Walker A/P-loop; other site 716541008236 ATP binding site [chemical binding]; other site 716541008237 Q-loop/lid; other site 716541008238 ABC transporter signature motif; other site 716541008239 Walker B; other site 716541008240 D-loop; other site 716541008241 H-loop/switch region; other site 716541008242 TOBE domain; Region: TOBE; pfam03459 716541008243 TOBE domain; Region: TOBE_2; pfam08402 716541008244 allantoate amidohydrolase; Reviewed; Region: PRK09290 716541008245 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 716541008246 active site 716541008247 metal binding site [ion binding]; metal-binding site 716541008248 dimer interface [polypeptide binding]; other site 716541008249 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 716541008250 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 716541008251 catalytic residue [active] 716541008252 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 716541008253 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 716541008254 Walker A/P-loop; other site 716541008255 ATP binding site [chemical binding]; other site 716541008256 Q-loop/lid; other site 716541008257 ABC transporter signature motif; other site 716541008258 Walker B; other site 716541008259 D-loop; other site 716541008260 H-loop/switch region; other site 716541008261 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 716541008262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541008263 dimer interface [polypeptide binding]; other site 716541008264 conserved gate region; other site 716541008265 putative PBP binding loops; other site 716541008266 ABC-ATPase subunit interface; other site 716541008267 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 716541008268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541008269 dimer interface [polypeptide binding]; other site 716541008270 conserved gate region; other site 716541008271 putative PBP binding loops; other site 716541008272 ABC-ATPase subunit interface; other site 716541008273 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541008274 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 716541008275 substrate binding pocket [chemical binding]; other site 716541008276 membrane-bound complex binding site; other site 716541008277 hinge residues; other site 716541008278 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 716541008279 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 716541008280 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 716541008281 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 716541008282 amidase; Provisional; Region: PRK09201 716541008283 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 716541008284 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 716541008285 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 716541008286 active site 716541008287 catalytic site [active] 716541008288 tetramer interface [polypeptide binding]; other site 716541008289 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 716541008290 Transcriptional regulators [Transcription]; Region: FadR; COG2186 716541008291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541008292 DNA-binding site [nucleotide binding]; DNA binding site 716541008293 FCD domain; Region: FCD; pfam07729 716541008294 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 716541008295 Na binding site [ion binding]; other site 716541008296 putative substrate binding site [chemical binding]; other site 716541008297 guanine deaminase; Provisional; Region: PRK09228 716541008298 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 716541008299 active site 716541008300 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 716541008301 active site 716541008302 homotetramer interface [polypeptide binding]; other site 716541008303 OHCU decarboxylase; Region: UraD_2; TIGR03180 716541008304 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541008305 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 716541008306 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 716541008307 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 716541008308 iron-sulfur cluster [ion binding]; other site 716541008309 [2Fe-2S] cluster binding site [ion binding]; other site 716541008310 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 716541008311 hydrophobic ligand binding site; other site 716541008312 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 716541008313 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 716541008314 FMN-binding pocket [chemical binding]; other site 716541008315 flavin binding motif; other site 716541008316 phosphate binding motif [ion binding]; other site 716541008317 beta-alpha-beta structure motif; other site 716541008318 NAD binding pocket [chemical binding]; other site 716541008319 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 716541008320 catalytic loop [active] 716541008321 iron binding site [ion binding]; other site 716541008322 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 716541008323 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 716541008324 intersubunit interface [polypeptide binding]; other site 716541008325 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716541008326 ABC-ATPase subunit interface; other site 716541008327 dimer interface [polypeptide binding]; other site 716541008328 putative PBP binding regions; other site 716541008329 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 716541008330 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 716541008331 Walker A/P-loop; other site 716541008332 ATP binding site [chemical binding]; other site 716541008333 Q-loop/lid; other site 716541008334 ABC transporter signature motif; other site 716541008335 Walker B; other site 716541008336 D-loop; other site 716541008337 H-loop/switch region; other site 716541008338 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 716541008339 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 716541008340 peptide binding site [polypeptide binding]; other site 716541008341 YccA-like proteins; Region: YccA_like; cd10433 716541008342 sulfur transfer protein TusE; Provisional; Region: PRK11508 716541008343 acylphosphatase; Provisional; Region: PRK14426 716541008344 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 716541008345 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 716541008346 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 716541008347 putative RNA binding site [nucleotide binding]; other site 716541008348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541008349 S-adenosylmethionine binding site [chemical binding]; other site 716541008350 heat shock protein HspQ; Provisional; Region: PRK14129 716541008351 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 716541008352 hypothetical protein; Provisional; Region: PRK03641 716541008353 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 716541008354 active site 716541008355 dimer interfaces [polypeptide binding]; other site 716541008356 catalytic residues [active] 716541008357 DNA helicase IV; Provisional; Region: helD; PRK11054 716541008358 DNA helicase IV / RNA helicase N terminal; Region: Helicase_IV_N; pfam12462 716541008359 Part of AAA domain; Region: AAA_19; pfam13245 716541008360 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 716541008361 Predicted membrane protein [Function unknown]; Region: COG3304 716541008362 Domain of unknown function (DUF307); Region: DUF307; pfam03733 716541008363 Domain of unknown function (DUF307); Region: DUF307; pfam03733 716541008364 TIGR01666 family membrane protein; Region: YCCS 716541008365 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 716541008366 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 716541008367 TfoX N-terminal domain; Region: TfoX_N; pfam04993 716541008368 TfoX C-terminal domain; Region: TfoX_C; pfam04994 716541008369 Cell division inhibitor SulA; Region: SulA; cl01880 716541008370 outer membrane protein A; Reviewed; Region: PRK10808 716541008371 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 716541008372 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 716541008373 ligand binding site [chemical binding]; other site 716541008374 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 716541008375 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 716541008376 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 716541008377 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 716541008378 active site 1 [active] 716541008379 dimer interface [polypeptide binding]; other site 716541008380 active site 2 [active] 716541008381 ribosome modulation factor; Provisional; Region: PRK14563 716541008382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 716541008383 paraquat-inducible protein B; Provisional; Region: PRK10807 716541008384 mce related protein; Region: MCE; pfam02470 716541008385 mce related protein; Region: MCE; pfam02470 716541008386 mce related protein; Region: MCE; pfam02470 716541008387 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 716541008388 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 716541008389 Paraquat-inducible protein A; Region: PqiA; pfam04403 716541008390 Paraquat-inducible protein A; Region: PqiA; pfam04403 716541008391 ABC transporter ATPase component; Reviewed; Region: PRK11147 716541008392 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716541008393 ABC transporter; Region: ABC_tran_2; pfam12848 716541008394 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716541008395 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 716541008396 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 716541008397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541008398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541008399 S-adenosylmethionine binding site [chemical binding]; other site 716541008400 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 716541008401 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 716541008402 MOSC domain; Region: MOSC; pfam03473 716541008403 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 716541008404 catalytic loop [active] 716541008405 iron binding site [ion binding]; other site 716541008406 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 716541008407 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 716541008408 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 716541008409 quinone interaction residues [chemical binding]; other site 716541008410 active site 716541008411 catalytic residues [active] 716541008412 FMN binding site [chemical binding]; other site 716541008413 substrate binding site [chemical binding]; other site 716541008414 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 716541008415 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541008416 substrate binding pocket [chemical binding]; other site 716541008417 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 716541008418 membrane-bound complex binding site; other site 716541008419 hinge residues; other site 716541008420 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 716541008421 active site 716541008422 dimer interface [polypeptide binding]; other site 716541008423 non-prolyl cis peptide bond; other site 716541008424 insertion regions; other site 716541008425 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 716541008426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541008427 dimer interface [polypeptide binding]; other site 716541008428 conserved gate region; other site 716541008429 putative PBP binding loops; other site 716541008430 ABC-ATPase subunit interface; other site 716541008431 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 716541008432 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 716541008433 Walker A/P-loop; other site 716541008434 ATP binding site [chemical binding]; other site 716541008435 Q-loop/lid; other site 716541008436 ABC transporter signature motif; other site 716541008437 Walker B; other site 716541008438 D-loop; other site 716541008439 H-loop/switch region; other site 716541008440 aminopeptidase N; Provisional; Region: pepN; PRK14015 716541008441 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 716541008442 active site 716541008443 Zn binding site [ion binding]; other site 716541008444 DinI-like family; Region: DinI; pfam06183 716541008445 Transposase; Region: HTH_Tnp_1; pfam01527 716541008446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 716541008447 HTH-like domain; Region: HTH_21; pfam13276 716541008448 Integrase core domain; Region: rve; pfam00665 716541008449 Integrase core domain; Region: rve_3; pfam13683 716541008450 putative transposase OrfB; Reviewed; Region: PHA02517 716541008451 HTH-like domain; Region: HTH_21; pfam13276 716541008452 Integrase core domain; Region: rve; pfam00665 716541008453 Integrase core domain; Region: rve_2; pfam13333 716541008454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541008455 Transposase; Region: HTH_Tnp_1; pfam01527 716541008456 Helix-turn-helix; Region: HTH_3; pfam01381 716541008457 Predicted transcriptional regulator [Transcription]; Region: COG2932 716541008458 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 716541008459 Catalytic site [active] 716541008460 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182 716541008461 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 716541008462 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 716541008463 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 716541008464 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 716541008465 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 716541008466 Int/Topo IB signature motif; other site 716541008467 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 716541008468 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 716541008469 active site 716541008470 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 716541008471 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 716541008472 putative anticodon binding site; other site 716541008473 putative dimer interface [polypeptide binding]; other site 716541008474 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 716541008475 homodimer interface [polypeptide binding]; other site 716541008476 motif 1; other site 716541008477 motif 2; other site 716541008478 active site 716541008479 motif 3; other site 716541008480 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 716541008481 trimer interface [polypeptide binding]; other site 716541008482 eyelet of channel; other site 716541008483 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 716541008484 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716541008485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541008486 homodimer interface [polypeptide binding]; other site 716541008487 catalytic residue [active] 716541008488 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 716541008489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 716541008490 Peptidase M15; Region: Peptidase_M15_3; cl01194 716541008491 murein L,D-transpeptidase; Provisional; Region: PRK10594 716541008492 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 716541008493 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 716541008494 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 716541008495 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 716541008496 P-loop containing region of AAA domain; Region: AAA_29; cl17516 716541008497 condesin subunit E; Provisional; Region: PRK05256 716541008498 condesin subunit F; Provisional; Region: PRK05260 716541008499 Methyltransferase domain; Region: Methyltransf_31; pfam13847 716541008500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541008501 S-adenosylmethionine binding site [chemical binding]; other site 716541008502 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 716541008503 putative active site [active] 716541008504 hypothetical protein; Provisional; Region: PRK10593 716541008505 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 716541008506 Ligand binding site; other site 716541008507 oligomer interface; other site 716541008508 Trm112p-like protein; Region: Trm112p; cl01066 716541008509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 716541008510 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 716541008511 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 716541008512 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 716541008513 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 716541008514 Walker A/P-loop; other site 716541008515 ATP binding site [chemical binding]; other site 716541008516 Q-loop/lid; other site 716541008517 ABC transporter signature motif; other site 716541008518 Walker B; other site 716541008519 D-loop; other site 716541008520 H-loop/switch region; other site 716541008521 ComEC family competence protein; Provisional; Region: PRK11539 716541008522 Competence protein; Region: Competence; pfam03772 716541008523 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 716541008524 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 716541008525 dimer interface [polypeptide binding]; other site 716541008526 DNA binding site [nucleotide binding] 716541008527 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 716541008528 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 716541008529 RNA binding site [nucleotide binding]; other site 716541008530 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 716541008531 RNA binding site [nucleotide binding]; other site 716541008532 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 716541008533 RNA binding site [nucleotide binding]; other site 716541008534 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 716541008535 RNA binding site [nucleotide binding]; other site 716541008536 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 716541008537 RNA binding site [nucleotide binding]; other site 716541008538 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 716541008539 RNA binding site [nucleotide binding]; other site 716541008540 cytidylate kinase; Provisional; Region: cmk; PRK00023 716541008541 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 716541008542 CMP-binding site; other site 716541008543 The sites determining sugar specificity; other site 716541008544 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 716541008545 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 716541008546 hinge; other site 716541008547 active site 716541008548 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 716541008549 homodimer interface [polypeptide binding]; other site 716541008550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541008551 substrate-cofactor binding pocket; other site 716541008552 catalytic residue [active] 716541008553 Predicted membrane protein [Function unknown]; Region: COG2323 716541008554 uncharacterized domain; Region: TIGR00702 716541008555 formate transporter; Provisional; Region: PRK10805 716541008556 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 716541008557 Pyruvate formate lyase 1; Region: PFL1; cd01678 716541008558 coenzyme A binding site [chemical binding]; other site 716541008559 active site 716541008560 catalytic residues [active] 716541008561 glycine loop; other site 716541008562 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 716541008563 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716541008564 FeS/SAM binding site; other site 716541008565 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 716541008566 putative MFS family transporter protein; Provisional; Region: PRK03633 716541008567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541008568 putative substrate translocation pore; other site 716541008569 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 716541008570 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 716541008571 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 716541008572 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 716541008573 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 716541008574 putative [Fe4-S4] binding site [ion binding]; other site 716541008575 putative molybdopterin cofactor binding site [chemical binding]; other site 716541008576 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 716541008577 putative molybdopterin cofactor binding site; other site 716541008578 seryl-tRNA synthetase; Provisional; Region: PRK05431 716541008579 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 716541008580 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 716541008581 dimer interface [polypeptide binding]; other site 716541008582 active site 716541008583 motif 1; other site 716541008584 motif 2; other site 716541008585 motif 3; other site 716541008586 recombination factor protein RarA; Reviewed; Region: PRK13342 716541008587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541008588 Walker A motif; other site 716541008589 ATP binding site [chemical binding]; other site 716541008590 Walker B motif; other site 716541008591 arginine finger; other site 716541008592 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 716541008593 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 716541008594 DNA translocase FtsK; Provisional; Region: PRK10263 716541008595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541008596 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 716541008597 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 716541008598 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 716541008599 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 716541008600 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716541008601 putative DNA binding site [nucleotide binding]; other site 716541008602 putative Zn2+ binding site [ion binding]; other site 716541008603 AsnC family; Region: AsnC_trans_reg; pfam01037 716541008604 thioredoxin reductase; Provisional; Region: PRK10262 716541008605 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541008606 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716541008607 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 716541008608 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 716541008609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541008610 Walker A/P-loop; other site 716541008611 ATP binding site [chemical binding]; other site 716541008612 Q-loop/lid; other site 716541008613 ABC transporter signature motif; other site 716541008614 Walker B; other site 716541008615 D-loop; other site 716541008616 H-loop/switch region; other site 716541008617 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 716541008618 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 716541008619 Walker A/P-loop; other site 716541008620 ATP binding site [chemical binding]; other site 716541008621 Q-loop/lid; other site 716541008622 ABC transporter signature motif; other site 716541008623 Walker B; other site 716541008624 D-loop; other site 716541008625 H-loop/switch region; other site 716541008626 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 716541008627 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 716541008628 rRNA binding site [nucleotide binding]; other site 716541008629 predicted 30S ribosome binding site; other site 716541008630 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 716541008631 Clp amino terminal domain; Region: Clp_N; pfam02861 716541008632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541008633 Walker A motif; other site 716541008634 ATP binding site [chemical binding]; other site 716541008635 Walker B motif; other site 716541008636 arginine finger; other site 716541008637 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541008638 Walker A motif; other site 716541008639 ATP binding site [chemical binding]; other site 716541008640 Walker B motif; other site 716541008641 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 716541008642 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 716541008643 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 716541008644 DNA-binding site [nucleotide binding]; DNA binding site 716541008645 RNA-binding motif; other site 716541008646 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 716541008647 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 716541008648 Walker A/P-loop; other site 716541008649 ATP binding site [chemical binding]; other site 716541008650 Q-loop/lid; other site 716541008651 ABC transporter signature motif; other site 716541008652 Walker B; other site 716541008653 D-loop; other site 716541008654 H-loop/switch region; other site 716541008655 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 716541008656 FtsX-like permease family; Region: FtsX; pfam02687 716541008657 macrolide transporter subunit MacA; Provisional; Region: PRK11578 716541008658 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541008659 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 716541008660 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541008661 Protein of unknown function (DUF535); Region: DUF535; pfam04393 716541008662 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 716541008663 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 716541008664 putative active site [active] 716541008665 putative metal-binding site [ion binding]; other site 716541008666 putative transposase OrfB; Reviewed; Region: PHA02517 716541008667 HTH-like domain; Region: HTH_21; pfam13276 716541008668 Integrase core domain; Region: rve; pfam00665 716541008669 Integrase core domain; Region: rve_2; pfam13333 716541008670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541008671 Transposase; Region: HTH_Tnp_1; pfam01527 716541008672 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 716541008673 amphipathic channel; other site 716541008674 Asn-Pro-Ala signature motifs; other site 716541008675 Predicted membrane protein [Function unknown]; Region: COG2431 716541008676 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 716541008677 cubane metal cluster [ion binding]; other site 716541008678 hybrid metal cluster; other site 716541008679 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 716541008680 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 716541008681 FAD binding pocket [chemical binding]; other site 716541008682 FAD binding motif [chemical binding]; other site 716541008683 phosphate binding motif [ion binding]; other site 716541008684 beta-alpha-beta structure motif; other site 716541008685 NAD binding pocket [chemical binding]; other site 716541008686 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 716541008687 catalytic loop [active] 716541008688 iron binding site [ion binding]; other site 716541008689 DoxX; Region: DoxX; pfam07681 716541008690 pyruvate dehydrogenase; Provisional; Region: PRK09124 716541008691 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 716541008692 PYR/PP interface [polypeptide binding]; other site 716541008693 dimer interface [polypeptide binding]; other site 716541008694 tetramer interface [polypeptide binding]; other site 716541008695 TPP binding site [chemical binding]; other site 716541008696 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 716541008697 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 716541008698 TPP-binding site [chemical binding]; other site 716541008699 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 716541008700 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 716541008701 tetramer interface [polypeptide binding]; other site 716541008702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541008703 catalytic residue [active] 716541008704 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 716541008705 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 716541008706 putative NAD(P) binding site [chemical binding]; other site 716541008707 putative active site [active] 716541008708 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 716541008709 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 716541008710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716541008711 NAD(P) binding site [chemical binding]; other site 716541008712 active site 716541008713 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 716541008714 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 716541008715 putative sugar binding site [chemical binding]; other site 716541008716 catalytic residues [active] 716541008717 DEC-1 protein, N-terminal region; Region: DEC-1_N; pfam04625 716541008718 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 716541008719 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 716541008720 aromatic chitin/cellulose binding site residues [chemical binding]; other site 716541008721 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 716541008722 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716541008723 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716541008724 catalytic residue [active] 716541008725 N-terminal Early set domain associated with the catalytic domain of chitinase; Region: E_set_Chitinase_N; cd02848 716541008726 Glyco_18 domain; Region: Glyco_18; smart00636 716541008727 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 716541008728 active site 716541008729 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 716541008730 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 716541008731 aromatic chitin/cellulose binding site residues [chemical binding]; other site 716541008732 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 716541008733 aromatic chitin/cellulose binding site residues [chemical binding]; other site 716541008734 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 716541008735 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 716541008736 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 716541008737 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 716541008738 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 716541008739 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 716541008740 GspL periplasmic domain; Region: GspL_C; pfam12693 716541008741 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 716541008742 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 716541008743 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 716541008744 type II secretion system protein J; Region: gspJ; TIGR01711 716541008745 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 716541008746 Prokaryotic N-terminal methylation site; Region: N_methyl_3; pfam13633 716541008747 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 716541008748 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 716541008749 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 716541008750 Type II transport protein GspH; Region: GspH; pfam12019 716541008751 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 716541008752 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 716541008753 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 716541008754 type II secretion system protein F; Region: GspF; TIGR02120 716541008755 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 716541008756 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 716541008757 type II secretion system protein E; Region: type_II_gspE; TIGR02533 716541008758 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 716541008759 Walker A motif; other site 716541008760 ATP binding site [chemical binding]; other site 716541008761 Walker B motif; other site 716541008762 type II secretion system protein D; Region: type_II_gspD; TIGR02517 716541008763 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 716541008764 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 716541008765 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 716541008766 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 716541008767 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 716541008768 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 716541008769 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 716541008770 protein secretion protein GspB; Provisional; Region: PRK09697 716541008771 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 716541008772 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 716541008773 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 716541008774 ligand binding site [chemical binding]; other site 716541008775 flexible hinge region; other site 716541008776 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 716541008777 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 716541008778 amidase catalytic site [active] 716541008779 Zn binding residues [ion binding]; other site 716541008780 substrate binding site [chemical binding]; other site 716541008781 hypothetical protein; Provisional; Region: PRK02877 716541008782 putative lipoprotein; Provisional; Region: PRK10533 716541008783 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 716541008784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541008785 Walker A/P-loop; other site 716541008786 ATP binding site [chemical binding]; other site 716541008787 Q-loop/lid; other site 716541008788 ABC transporter signature motif; other site 716541008789 Walker B; other site 716541008790 D-loop; other site 716541008791 H-loop/switch region; other site 716541008792 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 716541008793 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541008794 substrate binding pocket [chemical binding]; other site 716541008795 membrane-bound complex binding site; other site 716541008796 hinge residues; other site 716541008797 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 716541008798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541008799 dimer interface [polypeptide binding]; other site 716541008800 conserved gate region; other site 716541008801 putative PBP binding loops; other site 716541008802 ABC-ATPase subunit interface; other site 716541008803 arginine transporter permease subunit ArtM; Provisional; Region: artM; PRK11122 716541008804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541008805 dimer interface [polypeptide binding]; other site 716541008806 conserved gate region; other site 716541008807 putative PBP binding loops; other site 716541008808 ABC-ATPase subunit interface; other site 716541008809 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541008810 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 716541008811 substrate binding pocket [chemical binding]; other site 716541008812 membrane-bound complex binding site; other site 716541008813 hinge residues; other site 716541008814 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 716541008815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541008816 active site 716541008817 phosphorylation site [posttranslational modification] 716541008818 intermolecular recognition site; other site 716541008819 dimerization interface [polypeptide binding]; other site 716541008820 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541008821 DNA binding site [nucleotide binding] 716541008822 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 716541008823 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541008824 dimer interface [polypeptide binding]; other site 716541008825 phosphorylation site [posttranslational modification] 716541008826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541008827 ATP binding site [chemical binding]; other site 716541008828 Mg2+ binding site [ion binding]; other site 716541008829 G-X-G motif; other site 716541008830 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 716541008831 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 716541008832 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 716541008833 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 716541008834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541008835 dimer interface [polypeptide binding]; other site 716541008836 conserved gate region; other site 716541008837 putative PBP binding loops; other site 716541008838 ABC-ATPase subunit interface; other site 716541008839 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 716541008840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541008841 dimer interface [polypeptide binding]; other site 716541008842 conserved gate region; other site 716541008843 putative PBP binding loops; other site 716541008844 ABC-ATPase subunit interface; other site 716541008845 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 716541008846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541008847 Walker A/P-loop; other site 716541008848 ATP binding site [chemical binding]; other site 716541008849 Q-loop/lid; other site 716541008850 ABC transporter signature motif; other site 716541008851 Walker B; other site 716541008852 D-loop; other site 716541008853 H-loop/switch region; other site 716541008854 TOBE domain; Region: TOBE_2; pfam08402 716541008855 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 716541008856 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 716541008857 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 716541008858 RimK-like ATP-grasp domain; Region: RimK; pfam08443 716541008859 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 716541008860 dimer interface [polypeptide binding]; other site 716541008861 FMN binding site [chemical binding]; other site 716541008862 NADPH bind site [chemical binding]; other site 716541008863 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 716541008864 GSH binding site [chemical binding]; other site 716541008865 catalytic residues [active] 716541008866 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 716541008867 putative transporter; Provisional; Region: PRK04972 716541008868 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 716541008869 TrkA-C domain; Region: TrkA_C; pfam02080 716541008870 TrkA-C domain; Region: TrkA_C; pfam02080 716541008871 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 716541008872 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 716541008873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541008874 Transposase; Region: HTH_Tnp_1; cl17663 716541008875 putative transposase OrfB; Reviewed; Region: PHA02517 716541008876 HTH-like domain; Region: HTH_21; pfam13276 716541008877 Integrase core domain; Region: rve; pfam00665 716541008878 Integrase core domain; Region: rve_3; pfam13683 716541008879 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 716541008880 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 716541008881 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 716541008882 Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903 716541008883 Baseplate J-like protein; Region: Baseplate_J; cl01294 716541008884 Baseplate J-like protein; Region: Baseplate_J; pfam04865 716541008885 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 716541008886 Phage-related tail protein [Function unknown]; Region: COG5283 716541008887 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 716541008888 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 716541008889 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 716541008890 Phage holin family 2; Region: Phage_holin_2; pfam04550 716541008891 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 716541008892 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 716541008893 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 716541008894 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 716541008895 Phage small terminase subunit; Region: Phage_term_smal; cl19614 716541008896 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 716541008897 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 716541008898 terminase ATPase subunit; Provisional; Region: P; PHA02535 716541008899 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 716541008900 Phage Terminase; Region: Terminase_1; cl19862 716541008901 Phage portal protein; Region: Phage_portal; cl19194 716541008902 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 716541008903 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 716541008904 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 716541008905 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 716541008906 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 716541008907 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 716541008908 integrase; Provisional; Region: int; PHA02601 716541008909 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 716541008910 active site 716541008911 DNA binding site [nucleotide binding] 716541008912 Int/Topo IB signature motif; other site 716541008913 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716541008914 dimerization interface [polypeptide binding]; other site 716541008915 putative DNA binding site [nucleotide binding]; other site 716541008916 putative Zn2+ binding site [ion binding]; other site 716541008917 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 716541008918 Citrate transporter; Region: CitMHS; pfam03600 716541008919 transmembrane helices; other site 716541008920 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 716541008921 catalytic residues [active] 716541008922 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 716541008923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716541008924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541008925 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 716541008926 putative substrate translocation pore; other site 716541008927 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 716541008928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541008929 active site 716541008930 motif I; other site 716541008931 motif II; other site 716541008932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541008933 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 716541008934 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 716541008935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541008936 putative substrate translocation pore; other site 716541008937 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 716541008938 active site 716541008939 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 716541008940 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 716541008941 active site 716541008942 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 716541008943 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 716541008944 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 716541008945 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 716541008946 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 716541008947 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 716541008948 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 716541008949 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 716541008950 putative C-terminal domain interface [polypeptide binding]; other site 716541008951 putative GSH binding site (G-site) [chemical binding]; other site 716541008952 putative dimer interface [polypeptide binding]; other site 716541008953 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 716541008954 N-terminal domain interface [polypeptide binding]; other site 716541008955 dimer interface [polypeptide binding]; other site 716541008956 substrate binding pocket (H-site) [chemical binding]; other site 716541008957 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 716541008958 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 716541008959 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 716541008960 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 716541008961 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 716541008962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716541008963 FeS/SAM binding site; other site 716541008964 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 716541008965 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 716541008966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541008967 dimer interface [polypeptide binding]; other site 716541008968 conserved gate region; other site 716541008969 putative PBP binding loops; other site 716541008970 ABC-ATPase subunit interface; other site 716541008971 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 716541008972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541008973 dimer interface [polypeptide binding]; other site 716541008974 conserved gate region; other site 716541008975 putative PBP binding loops; other site 716541008976 ABC-ATPase subunit interface; other site 716541008977 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 716541008978 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 716541008979 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 716541008980 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716541008981 Walker A/P-loop; other site 716541008982 ATP binding site [chemical binding]; other site 716541008983 Q-loop/lid; other site 716541008984 ABC transporter signature motif; other site 716541008985 Walker B; other site 716541008986 D-loop; other site 716541008987 H-loop/switch region; other site 716541008988 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 716541008989 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716541008990 Walker A/P-loop; other site 716541008991 ATP binding site [chemical binding]; other site 716541008992 Q-loop/lid; other site 716541008993 ABC transporter signature motif; other site 716541008994 Walker B; other site 716541008995 D-loop; other site 716541008996 H-loop/switch region; other site 716541008997 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 716541008998 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 716541008999 catalytic nucleophile [active] 716541009000 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 716541009001 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 716541009002 dimer interface [polypeptide binding]; other site 716541009003 putative functional site; other site 716541009004 putative MPT binding site; other site 716541009005 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 716541009006 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 716541009007 ATP binding site [chemical binding]; other site 716541009008 substrate interface [chemical binding]; other site 716541009009 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 716541009010 active site 716541009011 intersubunit interactions; other site 716541009012 catalytic residue [active] 716541009013 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 716541009014 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716541009015 FeS/SAM binding site; other site 716541009016 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 716541009017 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 716541009018 dimer interface [polypeptide binding]; other site 716541009019 active site 716541009020 glycine loop; other site 716541009021 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 716541009022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541009023 active site 716541009024 motif I; other site 716541009025 motif II; other site 716541009026 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 716541009027 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 716541009028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541009029 D-galactonate transporter; Region: 2A0114; TIGR00893 716541009030 putative substrate translocation pore; other site 716541009031 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 716541009032 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 716541009033 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 716541009034 putative active site [active] 716541009035 putative catalytic site [active] 716541009036 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 716541009037 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716541009038 ABC transporter; Region: ABC_tran_2; pfam12848 716541009039 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716541009040 L,D-transpeptidase; Provisional; Region: PRK10260 716541009041 Lysin motif; Region: LysM; smart00257 716541009042 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 716541009043 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 716541009044 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541009045 DNA-binding site [nucleotide binding]; DNA binding site 716541009046 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 716541009047 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 716541009048 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 716541009049 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 716541009050 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 716541009051 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 716541009052 active site 716541009053 catalytic tetrad [active] 716541009054 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 716541009055 Outer membrane efflux protein; Region: OEP; pfam02321 716541009056 Outer membrane efflux protein; Region: OEP; pfam02321 716541009057 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 716541009058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541009059 putative substrate translocation pore; other site 716541009060 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 716541009061 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541009062 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541009063 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 716541009064 transmembrane helices; other site 716541009065 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 716541009066 manganese transport regulator MntR; Provisional; Region: PRK11050 716541009067 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 716541009068 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 716541009069 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 716541009070 Sulfatase; Region: Sulfatase; pfam00884 716541009071 outer membrane protein X; Provisional; Region: ompX; PRK09408 716541009072 threonine and homoserine efflux system; Provisional; Region: PRK10532 716541009073 EamA-like transporter family; Region: EamA; pfam00892 716541009074 Ferritin-like domain; Region: Ferritin; pfam00210 716541009075 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 716541009076 dimerization interface [polypeptide binding]; other site 716541009077 DPS ferroxidase diiron center [ion binding]; other site 716541009078 ion pore; other site 716541009079 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 716541009080 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541009081 substrate binding pocket [chemical binding]; other site 716541009082 membrane-bound complex binding site; other site 716541009083 hinge residues; other site 716541009084 glutamine ABC transporter permease protein; Reviewed; Region: glnP; PRK09494 716541009085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541009086 dimer interface [polypeptide binding]; other site 716541009087 conserved gate region; other site 716541009088 putative PBP binding loops; other site 716541009089 ABC-ATPase subunit interface; other site 716541009090 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 716541009091 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 716541009092 Walker A/P-loop; other site 716541009093 ATP binding site [chemical binding]; other site 716541009094 Q-loop/lid; other site 716541009095 ABC transporter signature motif; other site 716541009096 Walker B; other site 716541009097 D-loop; other site 716541009098 H-loop/switch region; other site 716541009099 putative mechanosensitive channel protein; Provisional; Region: PRK11465 716541009100 Mechanosensitive ion channel; Region: MS_channel; pfam00924 716541009101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541009102 S-adenosylmethionine binding site [chemical binding]; other site 716541009103 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 716541009104 hypothetical protein; Provisional; Region: PRK11019 716541009105 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 716541009106 glycosyl transferase family protein; Provisional; Region: PRK08136 716541009107 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 716541009108 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 716541009109 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 716541009110 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 716541009111 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 716541009112 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 716541009113 PapC N-terminal domain; Region: PapC_N; pfam13954 716541009114 Outer membrane usher protein; Region: Usher; pfam00577 716541009115 PapC C-terminal domain; Region: PapC_C; pfam13953 716541009116 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 716541009117 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 716541009118 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 716541009119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 716541009120 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 716541009121 putative transposase OrfB; Reviewed; Region: PHA02517 716541009122 HTH-like domain; Region: HTH_21; pfam13276 716541009123 Integrase core domain; Region: rve; pfam00665 716541009124 Integrase core domain; Region: rve_2; pfam13333 716541009125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541009126 Transposase; Region: HTH_Tnp_1; pfam01527 716541009127 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 716541009128 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 716541009129 ATP binding site [chemical binding]; other site 716541009130 Mg++ binding site [ion binding]; other site 716541009131 motif III; other site 716541009132 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716541009133 nucleotide binding region [chemical binding]; other site 716541009134 ATP-binding site [chemical binding]; other site 716541009135 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 716541009136 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716541009137 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 716541009138 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 716541009139 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541009140 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541009141 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 716541009142 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 716541009143 Walker A/P-loop; other site 716541009144 ATP binding site [chemical binding]; other site 716541009145 Q-loop/lid; other site 716541009146 ABC transporter signature motif; other site 716541009147 Walker B; other site 716541009148 D-loop; other site 716541009149 H-loop/switch region; other site 716541009150 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 716541009151 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 716541009152 Walker A/P-loop; other site 716541009153 ATP binding site [chemical binding]; other site 716541009154 Q-loop/lid; other site 716541009155 ABC transporter signature motif; other site 716541009156 Walker B; other site 716541009157 D-loop; other site 716541009158 H-loop/switch region; other site 716541009159 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 716541009160 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 716541009161 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 716541009162 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 716541009163 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 716541009164 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 716541009165 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 716541009166 putative catalytic site [active] 716541009167 putative metal binding site [ion binding]; other site 716541009168 putative phosphate binding site [ion binding]; other site 716541009169 cardiolipin synthase 2; Provisional; Region: PRK11263 716541009170 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 716541009171 putative active site [active] 716541009172 catalytic site [active] 716541009173 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 716541009174 putative active site [active] 716541009175 catalytic site [active] 716541009176 Predicted integral membrane protein [Function unknown]; Region: COG0392 716541009177 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 716541009178 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 716541009179 MoaE homodimer interface [polypeptide binding]; other site 716541009180 MoaD interaction [polypeptide binding]; other site 716541009181 active site residues [active] 716541009182 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 716541009183 MoaE interaction surface [polypeptide binding]; other site 716541009184 MoeB interaction surface [polypeptide binding]; other site 716541009185 thiocarboxylated glycine; other site 716541009186 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 716541009187 trimer interface [polypeptide binding]; other site 716541009188 dimer interface [polypeptide binding]; other site 716541009189 putative active site [active] 716541009190 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 716541009191 MPT binding site; other site 716541009192 trimer interface [polypeptide binding]; other site 716541009193 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 716541009194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716541009195 FeS/SAM binding site; other site 716541009196 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 716541009197 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 716541009198 phosphate binding site [ion binding]; other site 716541009199 putative substrate binding pocket [chemical binding]; other site 716541009200 dimer interface [polypeptide binding]; other site 716541009201 excinuclease ABC subunit B; Provisional; Region: PRK05298 716541009202 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716541009203 ATP binding site [chemical binding]; other site 716541009204 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716541009205 nucleotide binding region [chemical binding]; other site 716541009206 ATP-binding site [chemical binding]; other site 716541009207 Ultra-violet resistance protein B; Region: UvrB; pfam12344 716541009208 UvrB/uvrC motif; Region: UVR; pfam02151 716541009209 Acetokinase family; Region: Acetate_kinase; cl17229 716541009210 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 716541009211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541009212 Walker A/P-loop; other site 716541009213 ATP binding site [chemical binding]; other site 716541009214 Q-loop/lid; other site 716541009215 ABC transporter signature motif; other site 716541009216 Walker B; other site 716541009217 D-loop; other site 716541009218 H-loop/switch region; other site 716541009219 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 716541009220 AAA domain; Region: AAA_26; pfam13500 716541009221 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 716541009222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541009223 S-adenosylmethionine binding site [chemical binding]; other site 716541009224 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 716541009225 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 716541009226 substrate-cofactor binding pocket; other site 716541009227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541009228 catalytic residue [active] 716541009229 biotin synthase; Provisional; Region: PRK15108 716541009230 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716541009231 FeS/SAM binding site; other site 716541009232 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 716541009233 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 716541009234 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 716541009235 inhibitor-cofactor binding pocket; inhibition site 716541009236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541009237 catalytic residue [active] 716541009238 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 716541009239 substrate binding site [chemical binding]; other site 716541009240 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 716541009241 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 716541009242 active sites [active] 716541009243 tetramer interface [polypeptide binding]; other site 716541009244 urocanate hydratase; Provisional; Region: PRK05414 716541009245 histidine utilization repressor; Provisional; Region: PRK14999 716541009246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541009247 DNA-binding site [nucleotide binding]; DNA binding site 716541009248 UTRA domain; Region: UTRA; pfam07702 716541009249 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 716541009250 putative active site [active] 716541009251 putative metal binding site [ion binding]; other site 716541009252 imidazolonepropionase; Validated; Region: PRK09356 716541009253 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 716541009254 active site 716541009255 acyl-CoA thioesterase; Provisional; Region: PRK10531 716541009256 Pectinesterase; Region: Pectinesterase; cl01911 716541009257 6-phosphogluconolactonase; Provisional; Region: PRK11028 716541009258 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 716541009259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541009260 active site 716541009261 motif I; other site 716541009262 motif II; other site 716541009263 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 716541009264 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 716541009265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541009266 Walker A/P-loop; other site 716541009267 ATP binding site [chemical binding]; other site 716541009268 Q-loop/lid; other site 716541009269 ABC transporter signature motif; other site 716541009270 Walker B; other site 716541009271 D-loop; other site 716541009272 H-loop/switch region; other site 716541009273 molybdenum-pterin binding domain; Region: Mop; TIGR00638 716541009274 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 716541009275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541009276 dimer interface [polypeptide binding]; other site 716541009277 conserved gate region; other site 716541009278 putative PBP binding loops; other site 716541009279 ABC-ATPase subunit interface; other site 716541009280 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541009281 substrate binding pocket [chemical binding]; other site 716541009282 membrane-bound complex binding site; other site 716541009283 hinge residues; other site 716541009284 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 716541009285 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 716541009286 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 716541009287 molybdenum-pterin binding domain; Region: Mop; TIGR00638 716541009288 TOBE domain; Region: TOBE; pfam03459 716541009289 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 716541009290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541009291 Walker A/P-loop; other site 716541009292 ATP binding site [chemical binding]; other site 716541009293 Q-loop/lid; other site 716541009294 ABC transporter signature motif; other site 716541009295 Walker B; other site 716541009296 D-loop; other site 716541009297 H-loop/switch region; other site 716541009298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541009299 Walker A/P-loop; other site 716541009300 ATP binding site [chemical binding]; other site 716541009301 Q-loop/lid; other site 716541009302 ABC transporter signature motif; other site 716541009303 Walker B; other site 716541009304 D-loop; other site 716541009305 H-loop/switch region; other site 716541009306 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 716541009307 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 716541009308 NAD binding site [chemical binding]; other site 716541009309 homodimer interface [polypeptide binding]; other site 716541009310 active site 716541009311 substrate binding site [chemical binding]; other site 716541009312 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 716541009313 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 716541009314 dimer interface [polypeptide binding]; other site 716541009315 active site 716541009316 galactokinase; Provisional; Region: PRK05101 716541009317 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 716541009318 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 716541009319 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 716541009320 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 716541009321 active site 716541009322 catalytic residues [active] 716541009323 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 716541009324 catalytic core [active] 716541009325 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 716541009326 YbgS-like protein; Region: YbgS; pfam13985 716541009327 zinc transporter ZitB; Provisional; Region: PRK03557 716541009328 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 716541009329 quinolinate synthetase; Provisional; Region: PRK09375 716541009330 tol-pal system protein YbgF; Provisional; Region: PRK10803 716541009331 Tetratricopeptide repeat; Region: TPR_6; pfam13174 716541009332 Tetratricopeptide repeat; Region: TPR_6; pfam13174 716541009333 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 716541009334 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 716541009335 ligand binding site [chemical binding]; other site 716541009336 translocation protein TolB; Provisional; Region: tolB; PRK03629 716541009337 TolB amino-terminal domain; Region: TolB_N; pfam04052 716541009338 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 716541009339 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 716541009340 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 716541009341 TolA C-terminal; Region: TolA; pfam06519 716541009342 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 716541009343 colicin uptake protein TolR; Provisional; Region: PRK11024 716541009344 colicin uptake protein TolQ; Provisional; Region: PRK10801 716541009345 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 716541009346 active site 716541009347 hypothetical protein; Provisional; Region: PRK10588 716541009348 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 716541009349 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 716541009350 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 716541009351 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 716541009352 alpha-mannosidase; Provisional; Region: PRK09819 716541009353 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 716541009354 active site 716541009355 metal binding site [ion binding]; metal-binding site 716541009356 catalytic site [active] 716541009357 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 716541009358 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 716541009359 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 716541009360 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 716541009361 active site 716541009362 phosphorylation site [posttranslational modification] 716541009363 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 716541009364 active site 716541009365 P-loop; other site 716541009366 phosphorylation site [posttranslational modification] 716541009367 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 716541009368 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 716541009369 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541009370 DNA-binding site [nucleotide binding]; DNA binding site 716541009371 UTRA domain; Region: UTRA; pfam07702 716541009372 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 716541009373 CoA binding domain; Region: CoA_binding; pfam02629 716541009374 CoA-ligase; Region: Ligase_CoA; pfam00549 716541009375 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 716541009376 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 716541009377 CoA-ligase; Region: Ligase_CoA; pfam00549 716541009378 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 716541009379 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 716541009380 E3 interaction surface; other site 716541009381 lipoyl attachment site [posttranslational modification]; other site 716541009382 e3 binding domain; Region: E3_binding; pfam02817 716541009383 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 716541009384 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 716541009385 dimer interface [polypeptide binding]; other site 716541009386 PYR/PP interface [polypeptide binding]; other site 716541009387 TPP binding site [chemical binding]; other site 716541009388 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 716541009389 TPP-binding site [chemical binding]; other site 716541009390 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 716541009391 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 716541009392 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 716541009393 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 716541009394 L-aspartate oxidase; Provisional; Region: PRK06175 716541009395 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 716541009396 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 716541009397 SdhC subunit interface [polypeptide binding]; other site 716541009398 proximal heme binding site [chemical binding]; other site 716541009399 cardiolipin binding site; other site 716541009400 Iron-sulfur protein interface; other site 716541009401 proximal quinone binding site [chemical binding]; other site 716541009402 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 716541009403 Iron-sulfur protein interface; other site 716541009404 proximal quinone binding site [chemical binding]; other site 716541009405 SdhD (CybS) interface [polypeptide binding]; other site 716541009406 proximal heme binding site [chemical binding]; other site 716541009407 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 716541009408 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 716541009409 dimer interface [polypeptide binding]; other site 716541009410 active site 716541009411 citrylCoA binding site [chemical binding]; other site 716541009412 NADH binding [chemical binding]; other site 716541009413 cationic pore residues; other site 716541009414 oxalacetate/citrate binding site [chemical binding]; other site 716541009415 coenzyme A binding site [chemical binding]; other site 716541009416 catalytic triad [active] 716541009417 endonuclease VIII; Provisional; Region: PRK10445 716541009418 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 716541009419 DNA binding site [nucleotide binding] 716541009420 catalytic residue [active] 716541009421 putative catalytic residues [active] 716541009422 H2TH interface [polypeptide binding]; other site 716541009423 intercalation triad [nucleotide binding]; other site 716541009424 substrate specificity determining residue; other site 716541009425 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 716541009426 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 716541009427 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 716541009428 putative active site [active] 716541009429 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 716541009430 Allophanate hydrolase subunit 1; Region: AHS1; cl19310 716541009431 metal-binding protein; Provisional; Region: PRK10799 716541009432 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 716541009433 DNA photolyase; Region: DNA_photolyase; pfam00875 716541009434 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 716541009435 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 716541009436 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 716541009437 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 716541009438 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 716541009439 Soluble P-type ATPase [General function prediction only]; Region: COG4087 716541009440 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 716541009441 sensor protein KdpD; Provisional; Region: PRK10490 716541009442 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 716541009443 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 716541009444 Ligand Binding Site [chemical binding]; other site 716541009445 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 716541009446 GAF domain; Region: GAF_3; pfam13492 716541009447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541009448 dimer interface [polypeptide binding]; other site 716541009449 phosphorylation site [posttranslational modification] 716541009450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541009451 ATP binding site [chemical binding]; other site 716541009452 Mg2+ binding site [ion binding]; other site 716541009453 G-X-G motif; other site 716541009454 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 716541009455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541009456 active site 716541009457 phosphorylation site [posttranslational modification] 716541009458 intermolecular recognition site; other site 716541009459 dimerization interface [polypeptide binding]; other site 716541009460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541009461 DNA binding site [nucleotide binding] 716541009462 ornithine decarboxylase; Provisional; Region: PRK13578 716541009463 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 716541009464 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 716541009465 homodimer interface [polypeptide binding]; other site 716541009466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541009467 catalytic residue [active] 716541009468 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 716541009469 putrescine transporter; Provisional; Region: potE; PRK10655 716541009470 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 716541009471 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 716541009472 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 716541009473 active site 716541009474 substrate binding site [chemical binding]; other site 716541009475 metal binding site [ion binding]; metal-binding site 716541009476 replication initiation regulator SeqA; Provisional; Region: PRK11187 716541009477 acyl-CoA esterase; Provisional; Region: PRK10673 716541009478 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 716541009479 LexA regulated protein; Provisional; Region: PRK11675 716541009480 flavodoxin FldA; Validated; Region: PRK09267 716541009481 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 716541009482 metal binding site 2 [ion binding]; metal-binding site 716541009483 putative DNA binding helix; other site 716541009484 metal binding site 1 [ion binding]; metal-binding site 716541009485 dimer interface [polypeptide binding]; other site 716541009486 structural Zn2+ binding site [ion binding]; other site 716541009487 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 716541009488 YbfN-like lipoprotein; Region: YbfN; pfam13982 716541009489 outer membrane porin, OprD family; Region: OprD; pfam03573 716541009490 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 716541009491 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 716541009492 active site 716541009493 HIGH motif; other site 716541009494 KMSKS motif; other site 716541009495 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 716541009496 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 716541009497 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 716541009498 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 716541009499 active site turn [active] 716541009500 phosphorylation site [posttranslational modification] 716541009501 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 716541009502 HPr interaction site; other site 716541009503 glycerol kinase (GK) interaction site [polypeptide binding]; other site 716541009504 active site 716541009505 phosphorylation site [posttranslational modification] 716541009506 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 716541009507 active site 716541009508 trimer interface [polypeptide binding]; other site 716541009509 allosteric site; other site 716541009510 active site lid [active] 716541009511 hexamer (dimer of trimers) interface [polypeptide binding]; other site 716541009512 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 716541009513 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 716541009514 active site 716541009515 dimer interface [polypeptide binding]; other site 716541009516 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 716541009517 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 716541009518 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 716541009519 nucleotide binding site [chemical binding]; other site 716541009520 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 716541009521 UMP phosphatase; Provisional; Region: PRK10444 716541009522 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541009523 active site 716541009524 motif I; other site 716541009525 motif II; other site 716541009526 asparagine synthetase B; Provisional; Region: asnB; PRK09431 716541009527 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 716541009528 active site 716541009529 dimer interface [polypeptide binding]; other site 716541009530 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 716541009531 Ligand Binding Site [chemical binding]; other site 716541009532 Molecular Tunnel; other site 716541009533 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 716541009534 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 716541009535 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 716541009536 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 716541009537 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716541009538 FeS/SAM binding site; other site 716541009539 TRAM domain; Region: TRAM; pfam01938 716541009540 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 716541009541 PhoH-like protein; Region: PhoH; pfam02562 716541009542 metal-binding heat shock protein; Provisional; Region: PRK00016 716541009543 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 716541009544 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 716541009545 Transporter associated domain; Region: CorC_HlyC; smart01091 716541009546 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 716541009547 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 716541009548 putative active site [active] 716541009549 catalytic triad [active] 716541009550 putative dimer interface [polypeptide binding]; other site 716541009551 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 716541009552 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541009553 substrate binding pocket [chemical binding]; other site 716541009554 membrane-bound complex binding site; other site 716541009555 hinge residues; other site 716541009556 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 716541009557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541009558 dimer interface [polypeptide binding]; other site 716541009559 conserved gate region; other site 716541009560 putative PBP binding loops; other site 716541009561 ABC-ATPase subunit interface; other site 716541009562 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 716541009563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541009564 dimer interface [polypeptide binding]; other site 716541009565 conserved gate region; other site 716541009566 putative PBP binding loops; other site 716541009567 ABC-ATPase subunit interface; other site 716541009568 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 716541009569 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 716541009570 Walker A/P-loop; other site 716541009571 ATP binding site [chemical binding]; other site 716541009572 Q-loop/lid; other site 716541009573 ABC transporter signature motif; other site 716541009574 Walker B; other site 716541009575 D-loop; other site 716541009576 H-loop/switch region; other site 716541009577 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 716541009578 active site 716541009579 tetramer interface [polypeptide binding]; other site 716541009580 hypothetical protein; Provisional; Region: PRK11032 716541009581 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 716541009582 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 716541009583 active site 716541009584 HIGH motif; other site 716541009585 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 716541009586 KMSKS motif; other site 716541009587 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 716541009588 tRNA binding surface [nucleotide binding]; other site 716541009589 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 716541009590 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 716541009591 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 716541009592 Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840 716541009593 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 716541009594 active site 716541009595 (T/H)XGH motif; other site 716541009596 ribosome-associated protein; Provisional; Region: PRK11538 716541009597 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 716541009598 penicillin-binding protein 2; Provisional; Region: PRK10795 716541009599 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 716541009600 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 716541009601 cell wall shape-determining protein; Provisional; Region: PRK10794 716541009602 rare lipoprotein A; Provisional; Region: PRK10672 716541009603 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 716541009604 Sporulation related domain; Region: SPOR; pfam05036 716541009605 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 716541009606 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 716541009607 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 716541009608 hypothetical protein; Provisional; Region: PRK04998 716541009609 lipoate-protein ligase B; Provisional; Region: PRK14342 716541009610 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 716541009611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541009612 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541009613 dimerization interface [polypeptide binding]; other site 716541009614 lipoyl synthase; Provisional; Region: PRK05481 716541009615 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716541009616 FeS/SAM binding site; other site 716541009617 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 716541009618 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 716541009619 putative active site [active] 716541009620 catalytic triad [active] 716541009621 putative dimer interface [polypeptide binding]; other site 716541009622 chromosome condensation membrane protein; Provisional; Region: PRK14196 716541009623 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 716541009624 DNA-binding site [nucleotide binding]; DNA binding site 716541009625 RNA-binding motif; other site 716541009626 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 716541009627 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 716541009628 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 716541009629 ribonuclease I; Provisional; Region: PRK10095 716541009630 CAS motifs; other site 716541009631 active site 716541009632 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 716541009633 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 716541009634 Rnk N-terminus; Region: Rnk_N; pfam14760 716541009635 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 716541009636 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 716541009637 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 716541009638 NAD binding site [chemical binding]; other site 716541009639 catalytic Zn binding site [ion binding]; other site 716541009640 structural Zn binding site [ion binding]; other site 716541009641 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 716541009642 Ligand Binding Site [chemical binding]; other site 716541009643 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 716541009644 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 716541009645 catalytic residue [active] 716541009646 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 716541009647 catalytic residues [active] 716541009648 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541009649 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716541009650 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 716541009651 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 716541009652 dimer interface [polypeptide binding]; other site 716541009653 decamer (pentamer of dimers) interface [polypeptide binding]; other site 716541009654 catalytic triad [active] 716541009655 peroxidatic and resolving cysteines [active] 716541009656 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541009657 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541009658 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541009659 dimerization interface [polypeptide binding]; other site 716541009660 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 716541009661 Active Sites [active] 716541009662 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 716541009663 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 716541009664 ParB-like nuclease domain; Region: ParBc; pfam02195 716541009665 methionine aminotransferase; Validated; Region: PRK09082 716541009666 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716541009667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541009668 homodimer interface [polypeptide binding]; other site 716541009669 catalytic residue [active] 716541009670 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 716541009671 intersubunit interface [polypeptide binding]; other site 716541009672 active site 716541009673 Zn2+ binding site [ion binding]; other site 716541009674 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 716541009675 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 716541009676 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541009677 motif II; other site 716541009678 Cupin domain; Region: Cupin_2; cl17218 716541009679 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 716541009680 putative hydrophobic ligand binding site [chemical binding]; other site 716541009681 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 716541009682 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 716541009683 putative invasin; Provisional; Region: PRK10177 716541009684 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 716541009685 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 716541009686 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 716541009687 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 716541009688 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 716541009689 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 716541009690 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 716541009691 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 716541009692 Uncharacterized conserved protein [Function unknown]; Region: COG5276 716541009693 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 716541009694 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 716541009695 putative ligand binding site [chemical binding]; other site 716541009696 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 716541009697 TM-ABC transporter signature motif; other site 716541009698 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 716541009699 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 716541009700 Walker A/P-loop; other site 716541009701 ATP binding site [chemical binding]; other site 716541009702 Q-loop/lid; other site 716541009703 ABC transporter signature motif; other site 716541009704 Walker B; other site 716541009705 D-loop; other site 716541009706 H-loop/switch region; other site 716541009707 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 716541009708 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 716541009709 putative active site [active] 716541009710 metal binding site [ion binding]; metal-binding site 716541009711 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 716541009712 classical (c) SDRs; Region: SDR_c; cd05233 716541009713 NAD(P) binding site [chemical binding]; other site 716541009714 active site 716541009715 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 716541009716 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 716541009717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541009718 salt bridge; other site 716541009719 non-specific DNA binding site [nucleotide binding]; other site 716541009720 sequence-specific DNA binding site [nucleotide binding]; other site 716541009721 Uncharacterized small protein [Function unknown]; Region: COG2879 716541009722 carbon starvation protein A; Provisional; Region: PRK15015 716541009723 Carbon starvation protein CstA; Region: CstA; pfam02554 716541009724 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 716541009725 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 716541009726 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 716541009727 metal binding site [ion binding]; metal-binding site 716541009728 dimer interface [polypeptide binding]; other site 716541009729 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 716541009730 CoenzymeA binding site [chemical binding]; other site 716541009731 subunit interaction site [polypeptide binding]; other site 716541009732 PHB binding site; other site 716541009733 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 716541009734 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 716541009735 putative NAD(P) binding site [chemical binding]; other site 716541009736 active site 716541009737 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 716541009738 hydrophobic substrate binding pocket; other site 716541009739 active site 716541009740 conserved cis-peptide bond; other site 716541009741 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 716541009742 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 716541009743 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 716541009744 acyl-activating enzyme (AAE) consensus motif; other site 716541009745 active site 716541009746 AMP binding site [chemical binding]; other site 716541009747 substrate binding site [chemical binding]; other site 716541009748 isochorismate synthase EntC; Provisional; Region: PRK15016 716541009749 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 716541009750 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 716541009751 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 716541009752 siderophore binding site; other site 716541009753 enterobactin exporter EntS; Provisional; Region: PRK10489 716541009754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541009755 putative substrate translocation pore; other site 716541009756 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716541009757 ABC-ATPase subunit interface; other site 716541009758 dimer interface [polypeptide binding]; other site 716541009759 putative PBP binding regions; other site 716541009760 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716541009761 ABC-ATPase subunit interface; other site 716541009762 dimer interface [polypeptide binding]; other site 716541009763 putative PBP binding regions; other site 716541009764 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 716541009765 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 716541009766 Walker A/P-loop; other site 716541009767 ATP binding site [chemical binding]; other site 716541009768 Q-loop/lid; other site 716541009769 ABC transporter signature motif; other site 716541009770 Walker B; other site 716541009771 D-loop; other site 716541009772 H-loop/switch region; other site 716541009773 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 716541009774 Condensation domain; Region: Condensation; cl19241 716541009775 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 716541009776 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 716541009777 acyl-activating enzyme (AAE) consensus motif; other site 716541009778 AMP binding site [chemical binding]; other site 716541009779 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 716541009780 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 716541009781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 716541009782 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 716541009783 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 716541009784 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 716541009785 outer membrane receptor FepA; Provisional; Region: PRK13524 716541009786 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 716541009787 N-terminal plug; other site 716541009788 ligand-binding site [chemical binding]; other site 716541009789 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 716541009790 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 716541009791 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541009792 non-specific DNA binding site [nucleotide binding]; other site 716541009793 salt bridge; other site 716541009794 sequence-specific DNA binding site [nucleotide binding]; other site 716541009795 choline transport protein BetT; Provisional; Region: PRK09928 716541009796 transcriptional regulator BetI; Validated; Region: PRK00767 716541009797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716541009798 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 716541009799 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 716541009800 tetrameric interface [polypeptide binding]; other site 716541009801 NAD binding site [chemical binding]; other site 716541009802 catalytic residues [active] 716541009803 choline dehydrogenase; Validated; Region: PRK02106 716541009804 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 716541009805 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 716541009806 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 716541009807 DNA-binding site [nucleotide binding]; DNA binding site 716541009808 RNA-binding motif; other site 716541009809 acetoin reductase; Validated; Region: PRK08643 716541009810 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 716541009811 NAD binding site [chemical binding]; other site 716541009812 homotetramer interface [polypeptide binding]; other site 716541009813 homodimer interface [polypeptide binding]; other site 716541009814 active site 716541009815 substrate binding site [chemical binding]; other site 716541009816 acetolactate synthase; Reviewed; Region: PRK08617 716541009817 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 716541009818 PYR/PP interface [polypeptide binding]; other site 716541009819 dimer interface [polypeptide binding]; other site 716541009820 TPP binding site [chemical binding]; other site 716541009821 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 716541009822 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 716541009823 TPP-binding site [chemical binding]; other site 716541009824 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 716541009825 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541009826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541009827 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541009828 dimerization interface [polypeptide binding]; other site 716541009829 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541009830 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541009831 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 716541009832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541009833 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 716541009834 non-specific DNA binding site [nucleotide binding]; other site 716541009835 salt bridge; other site 716541009836 sequence-specific DNA binding site [nucleotide binding]; other site 716541009837 Immunity protein 7; Region: Imm7; pfam15588 716541009838 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 716541009839 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 716541009840 PAAR motif; Region: PAAR_motif; pfam05488 716541009841 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 716541009842 RHS Repeat; Region: RHS_repeat; pfam05593 716541009843 RHS Repeat; Region: RHS_repeat; pfam05593 716541009844 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 716541009845 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 716541009846 RHS Repeat; Region: RHS_repeat; pfam05593 716541009847 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 716541009848 RHS protein; Region: RHS; pfam03527 716541009849 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 716541009850 GHH signature containing HNH/Endo VII superfamily nuclease toxin; Region: Tox-GHH; pfam15636 716541009851 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 716541009852 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 716541009853 PAAR motif; Region: PAAR_motif; pfam05488 716541009854 PAAR motif; Region: PAAR_motif; pfam05488 716541009855 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 716541009856 Helix-turn-helix domain; Region: HTH_18; pfam12833 716541009857 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 716541009858 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 716541009859 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 716541009860 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 716541009861 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 716541009862 MMPL family; Region: MMPL; cl14618 716541009863 MMPL family; Region: MMPL; cl14618 716541009864 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 716541009865 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541009866 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541009867 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 716541009868 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 716541009869 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 716541009870 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 716541009871 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541009872 motif II; other site 716541009873 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 716541009874 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 716541009875 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 716541009876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541009877 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541009878 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 716541009879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 716541009880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716541009881 hypothetical protein; Provisional; Region: PRK10250 716541009882 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 716541009883 dimer interface [polypeptide binding]; other site 716541009884 FMN binding site [chemical binding]; other site 716541009885 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541009886 non-specific DNA binding site [nucleotide binding]; other site 716541009887 salt bridge; other site 716541009888 sequence-specific DNA binding site [nucleotide binding]; other site 716541009889 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 716541009890 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541009891 salt bridge; other site 716541009892 non-specific DNA binding site [nucleotide binding]; other site 716541009893 sequence-specific DNA binding site [nucleotide binding]; other site 716541009894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541009895 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716541009896 putative substrate translocation pore; other site 716541009897 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 716541009898 Mechanosensitive ion channel; Region: MS_channel; pfam00924 716541009899 Transcriptional regulators [Transcription]; Region: PurR; COG1609 716541009900 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541009901 DNA binding site [nucleotide binding] 716541009902 domain linker motif; other site 716541009903 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 716541009904 dimerization interface [polypeptide binding]; other site 716541009905 ligand binding site [chemical binding]; other site 716541009906 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 716541009907 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 716541009908 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 716541009909 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 716541009910 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 716541009911 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 716541009912 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 716541009913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541009914 putative substrate translocation pore; other site 716541009915 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 716541009916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541009917 non-specific DNA binding site [nucleotide binding]; other site 716541009918 salt bridge; other site 716541009919 sequence-specific DNA binding site [nucleotide binding]; other site 716541009920 phenylalanine transporter; Provisional; Region: PRK10249 716541009921 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 716541009922 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 716541009923 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 716541009924 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 716541009925 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 716541009926 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 716541009927 N-terminal plug; other site 716541009928 ligand-binding site [chemical binding]; other site 716541009929 hypothetical protein; Provisional; Region: PRK09929 716541009930 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 716541009931 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 716541009932 Walker A/P-loop; other site 716541009933 ATP binding site [chemical binding]; other site 716541009934 Q-loop/lid; other site 716541009935 ABC transporter signature motif; other site 716541009936 Walker B; other site 716541009937 D-loop; other site 716541009938 H-loop/switch region; other site 716541009939 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 716541009940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541009941 dimer interface [polypeptide binding]; other site 716541009942 conserved gate region; other site 716541009943 putative PBP binding loops; other site 716541009944 ABC-ATPase subunit interface; other site 716541009945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541009946 dimer interface [polypeptide binding]; other site 716541009947 conserved gate region; other site 716541009948 putative PBP binding loops; other site 716541009949 ABC-ATPase subunit interface; other site 716541009950 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 716541009951 CAAX protease self-immunity; Region: Abi; pfam02517 716541009952 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 716541009953 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 716541009954 Ligand binding site; other site 716541009955 Putative Catalytic site; other site 716541009956 DXD motif; other site 716541009957 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 716541009958 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 716541009959 Phage-related protein, tail component [Function unknown]; Region: COG4733 716541009960 NlpC/P60 family; Region: NLPC_P60; cl17555 716541009961 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 716541009962 Phage-related minor tail protein [Function unknown]; Region: COG5281 716541009963 tape measure domain; Region: tape_meas_nterm; TIGR02675 716541009964 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 716541009965 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 716541009966 Phage terminase large subunit; Region: Terminase_3; cl12054 716541009967 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 716541009968 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 716541009969 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 716541009970 catalytic residues [active] 716541009971 Lysis protein S; Region: Lysis_S; pfam04971 716541009972 Transposase; Region: HTH_Tnp_1; cl17663 716541009973 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541009974 IS2 transposase TnpB; Reviewed; Region: PRK09409 716541009975 HTH-like domain; Region: HTH_21; pfam13276 716541009976 Integrase core domain; Region: rve; pfam00665 716541009977 Integrase core domain; Region: rve_3; pfam13683 716541009978 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 716541009979 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 716541009980 NinB protein; Region: NinB; pfam05772 716541009981 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 716541009982 putative transposase OrfB; Reviewed; Region: PHA02517 716541009983 HTH-like domain; Region: HTH_21; pfam13276 716541009984 Integrase core domain; Region: rve; pfam00665 716541009985 Integrase core domain; Region: rve_3; pfam13683 716541009986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541009987 Transposase; Region: HTH_Tnp_1; cl17663 716541009988 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 716541009989 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 716541009990 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 716541009991 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 716541009992 FliG N-terminal domain; Region: FliG_N; pfam14842 716541009993 flagellar motor switch protein FliG; Region: fliG; TIGR00207 716541009994 FliG middle domain; Region: FliG_M; pfam14841 716541009995 FliG C-terminal domain; Region: FliG_C; pfam01706 716541009996 flagellar assembly protein H; Validated; Region: fliH; PRK05687 716541009997 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 716541009998 Flagellar assembly protein FliH; Region: FliH; pfam02108 716541009999 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 716541010000 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 716541010001 Walker A motif/ATP binding site; other site 716541010002 Walker B motif; other site 716541010003 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 716541010004 flagellar hook-length control protein; Provisional; Region: PRK10118 716541010005 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 716541010006 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 716541010007 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 716541010008 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 716541010009 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 716541010010 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 716541010011 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 716541010012 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 716541010013 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 716541010014 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 716541010015 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541010016 DNA binding residues [nucleotide binding] 716541010017 dimerization interface [polypeptide binding]; other site 716541010018 hypothetical protein; Provisional; Region: PRK10708 716541010019 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 716541010020 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 716541010021 mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486 716541010022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541010023 active site 716541010024 motif I; other site 716541010025 motif II; other site 716541010026 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 716541010027 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541010028 metal binding site [ion binding]; metal-binding site 716541010029 active site 716541010030 I-site; other site 716541010031 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 716541010032 hypothetical protein; Provisional; Region: PRK10062 716541010033 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 716541010034 EamA-like transporter family; Region: EamA; pfam00892 716541010035 EamA-like transporter family; Region: EamA; pfam00892 716541010036 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 716541010037 additional DNA contacts [nucleotide binding]; other site 716541010038 mismatch recognition site; other site 716541010039 active site 716541010040 zinc binding site [ion binding]; other site 716541010041 DNA intercalation site [nucleotide binding]; other site 716541010042 DNA cytosine methylase; Provisional; Region: PRK10458 716541010043 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 716541010044 cofactor binding site; other site 716541010045 DNA binding site [nucleotide binding] 716541010046 substrate interaction site [chemical binding]; other site 716541010047 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 716541010048 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 716541010049 Zn2+ binding site [ion binding]; other site 716541010050 Mg2+ binding site [ion binding]; other site 716541010051 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 716541010052 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 716541010053 trimer interface [polypeptide binding]; other site 716541010054 eyelet of channel; other site 716541010055 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 716541010056 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 716541010057 putative active site [active] 716541010058 sensory histidine kinase DcuS; Provisional; Region: PRK11086 716541010059 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 716541010060 PAS domain; Region: PAS; smart00091 716541010061 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 716541010062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541010063 ATP binding site [chemical binding]; other site 716541010064 Mg2+ binding site [ion binding]; other site 716541010065 G-X-G motif; other site 716541010066 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 716541010067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541010068 active site 716541010069 phosphorylation site [posttranslational modification] 716541010070 intermolecular recognition site; other site 716541010071 Thioredoxin; Region: Thioredoxin_4; cl17273 716541010072 dimerization interface [polypeptide binding]; other site 716541010073 ApbE family; Region: ApbE; pfam02424 716541010074 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 716541010075 putative active site [active] 716541010076 putative FMN binding site [chemical binding]; other site 716541010077 putative substrate binding site [chemical binding]; other site 716541010078 putative catalytic residue [active] 716541010079 FMN-binding domain; Region: FMN_bind; cl01081 716541010080 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 716541010081 L-aspartate oxidase; Provisional; Region: PRK06175 716541010082 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 716541010083 anion transporter; Region: dass; TIGR00785 716541010084 transmembrane helices; other site 716541010085 fumarate hydratase; Provisional; Region: PRK15389 716541010086 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 716541010087 Fumarase C-terminus; Region: Fumerase_C; pfam05683 716541010088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541010089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541010090 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 716541010091 dimerization interface [polypeptide binding]; other site 716541010092 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 716541010093 citrate-proton symporter; Provisional; Region: PRK15075 716541010094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541010095 putative substrate translocation pore; other site 716541010096 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 716541010097 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541010098 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541010099 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 716541010100 putative dimerization interface [polypeptide binding]; other site 716541010101 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 716541010102 putative CheA interaction surface; other site 716541010103 chemotaxis protein CheA; Provisional; Region: PRK10547 716541010104 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 716541010105 putative binding surface; other site 716541010106 active site 716541010107 CheY binding; Region: CheY-binding; pfam09078 716541010108 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 716541010109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541010110 ATP binding site [chemical binding]; other site 716541010111 Mg2+ binding site [ion binding]; other site 716541010112 G-X-G motif; other site 716541010113 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 716541010114 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 716541010115 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 716541010116 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 716541010117 ligand binding site [chemical binding]; other site 716541010118 flagellar motor protein MotA; Validated; Region: PRK09110 716541010119 transcriptional activator FlhC; Provisional; Region: PRK12722 716541010120 transcriptional activator FlhD; Provisional; Region: PRK02909 716541010121 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 716541010122 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 716541010123 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 716541010124 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 716541010125 DNA binding residues [nucleotide binding] 716541010126 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 716541010127 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541010128 dimerization interface [polypeptide binding]; other site 716541010129 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716541010130 dimer interface [polypeptide binding]; other site 716541010131 putative CheW interface [polypeptide binding]; other site 716541010132 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 716541010133 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 716541010134 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 716541010135 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 716541010136 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 716541010137 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 716541010138 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 716541010139 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 716541010140 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 716541010141 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 716541010142 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 716541010143 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 716541010144 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 716541010145 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 716541010146 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 716541010147 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 716541010148 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 716541010149 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 716541010150 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 716541010151 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 716541010152 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 716541010153 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 716541010154 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 716541010155 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 716541010156 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 716541010157 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 716541010158 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 716541010159 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 716541010160 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 716541010161 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 716541010162 FlgN protein; Region: FlgN; cl09176 716541010163 Flagellar protein FliT; Region: FliT; pfam05400 716541010164 flagellar protein FliS; Validated; Region: fliS; PRK05685 716541010165 flagellar capping protein; Reviewed; Region: fliD; PRK08032 716541010166 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 716541010167 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 716541010168 flagellin; Validated; Region: PRK06819 716541010169 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 716541010170 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 716541010171 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 716541010172 Predicted membrane protein [Function unknown]; Region: COG2259 716541010173 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 716541010174 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 716541010175 DNA binding site [nucleotide binding] 716541010176 potential frameshift: common BLAST hit: gi|292900268|ref|YP_003539637.1| flagellar biosynthetic protein 716541010177 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 716541010178 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 716541010179 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 716541010180 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 716541010181 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 716541010182 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 716541010183 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 716541010184 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 716541010185 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 716541010186 flagellar hook-length control protein; Provisional; Region: PRK10118 716541010187 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 716541010188 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 716541010189 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 716541010190 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 716541010191 Walker A motif/ATP binding site; other site 716541010192 Walker B motif; other site 716541010193 flagellar assembly protein H; Validated; Region: fliH; PRK05687 716541010194 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 716541010195 Flagellar assembly protein FliH; Region: FliH; pfam02108 716541010196 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 716541010197 FliG N-terminal domain; Region: FliG_N; pfam14842 716541010198 FliG middle domain; Region: FliG_M; pfam14841 716541010199 FliG C-terminal domain; Region: FliG_C; pfam01706 716541010200 potential frameshift: common BLAST hit: gi|259907606|ref|YP_002647962.1| Flagellar basal-body M-ring protein 716541010201 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 716541010202 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 716541010203 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 716541010204 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 716541010205 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 716541010206 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 716541010207 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 716541010208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541010209 S-adenosylmethionine binding site [chemical binding]; other site 716541010210 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 716541010211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541010212 active site 716541010213 phosphorylation site [posttranslational modification] 716541010214 intermolecular recognition site; other site 716541010215 dimerization interface [polypeptide binding]; other site 716541010216 CheB methylesterase; Region: CheB_methylest; pfam01339 716541010217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541010218 active site 716541010219 phosphorylation site [posttranslational modification] 716541010220 intermolecular recognition site; other site 716541010221 dimerization interface [polypeptide binding]; other site 716541010222 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 716541010223 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 716541010224 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 716541010225 Flagellar protein FlhE; Region: FlhE; pfam06366 716541010226 Chorismate mutase type II; Region: CM_2; cl00693 716541010227 Chorismate mutase type II; Region: CM_2; cl00693 716541010228 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 716541010229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541010230 putative substrate translocation pore; other site 716541010231 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 716541010232 IucA / IucC family; Region: IucA_IucC; pfam04183 716541010233 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 716541010234 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 716541010235 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 716541010236 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 716541010237 IucA / IucC family; Region: IucA_IucC; pfam04183 716541010238 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 716541010239 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 716541010240 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541010241 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 716541010242 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 716541010243 N-terminal plug; other site 716541010244 ligand-binding site [chemical binding]; other site 716541010245 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 716541010246 homotrimer interaction site [polypeptide binding]; other site 716541010247 putative active site [active] 716541010248 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541010249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541010250 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 716541010251 putative effector binding pocket; other site 716541010252 putative dimerization interface [polypeptide binding]; other site 716541010253 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 716541010254 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541010255 dimerization interface [polypeptide binding]; other site 716541010256 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 716541010257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541010258 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 716541010259 putative dimerization interface [polypeptide binding]; other site 716541010260 L,D-transpeptidase; Provisional; Region: PRK10190 716541010261 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 716541010262 shikimate transporter; Provisional; Region: PRK09952 716541010263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541010264 putative substrate translocation pore; other site 716541010265 AMP nucleosidase; Provisional; Region: PRK08292 716541010266 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 716541010267 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 716541010268 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 716541010269 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 716541010270 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 716541010271 active site 716541010272 MATE family multidrug exporter; Provisional; Region: PRK10189 716541010273 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 716541010274 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 716541010275 putative active site pocket [active] 716541010276 dimerization interface [polypeptide binding]; other site 716541010277 putative catalytic residue [active] 716541010278 hypothetical protein; Provisional; Region: PRK05423 716541010279 Predicted membrane protein [Function unknown]; Region: COG1289 716541010280 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 716541010281 DNA gyrase inhibitor; Provisional; Region: PRK10016 716541010282 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 716541010283 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 716541010284 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 716541010285 exonuclease I; Provisional; Region: sbcB; PRK11779 716541010286 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 716541010287 active site 716541010288 catalytic site [active] 716541010289 substrate binding site [chemical binding]; other site 716541010290 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 716541010291 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 716541010292 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 716541010293 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541010294 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 716541010295 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541010296 dimerization interface [polypeptide binding]; other site 716541010297 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 716541010298 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 716541010299 putative NAD(P) binding site [chemical binding]; other site 716541010300 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 716541010301 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 716541010302 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 716541010303 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 716541010304 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 716541010305 NAD binding site [chemical binding]; other site 716541010306 dimerization interface [polypeptide binding]; other site 716541010307 product binding site; other site 716541010308 substrate binding site [chemical binding]; other site 716541010309 zinc binding site [ion binding]; other site 716541010310 catalytic residues [active] 716541010311 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 716541010312 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716541010313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541010314 homodimer interface [polypeptide binding]; other site 716541010315 catalytic residue [active] 716541010316 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 716541010317 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541010318 active site 716541010319 motif I; other site 716541010320 motif II; other site 716541010321 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 716541010322 putative active site pocket [active] 716541010323 4-fold oligomerization interface [polypeptide binding]; other site 716541010324 metal binding residues [ion binding]; metal-binding site 716541010325 3-fold/trimer interface [polypeptide binding]; other site 716541010326 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 716541010327 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 716541010328 putative active site [active] 716541010329 oxyanion strand; other site 716541010330 catalytic triad [active] 716541010331 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 716541010332 catalytic residues [active] 716541010333 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 716541010334 substrate binding site [chemical binding]; other site 716541010335 glutamase interaction surface [polypeptide binding]; other site 716541010336 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 716541010337 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 716541010338 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 716541010339 metal binding site [ion binding]; metal-binding site 716541010340 chain length determinant protein WzzB; Provisional; Region: PRK15471 716541010341 Chain length determinant protein; Region: Wzz; pfam02706 716541010342 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 716541010343 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 716541010344 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 716541010345 putative NAD(P) binding site [chemical binding]; other site 716541010346 active site 716541010347 putative substrate binding site [chemical binding]; other site 716541010348 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 716541010349 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 716541010350 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 716541010351 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 716541010352 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 716541010353 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 716541010354 substrate binding site; other site 716541010355 tetramer interface; other site 716541010356 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 716541010357 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 716541010358 NAD binding site [chemical binding]; other site 716541010359 substrate binding site [chemical binding]; other site 716541010360 homodimer interface [polypeptide binding]; other site 716541010361 active site 716541010362 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 716541010363 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 716541010364 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 716541010365 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 716541010366 CoA binding domain; Region: CoA_binding; cl17356 716541010367 Bacterial sugar transferase; Region: Bac_transf; pfam02397 716541010368 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 716541010369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 716541010370 UDP-galactopyranose mutase; Region: GLF; pfam03275 716541010371 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 716541010372 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 716541010373 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 716541010374 active site 716541010375 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 716541010376 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 716541010377 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 716541010378 pseudaminic acid synthase; Region: PseI; TIGR03586 716541010379 NeuB family; Region: NeuB; pfam03102 716541010380 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 716541010381 NeuB binding interface [polypeptide binding]; other site 716541010382 putative substrate binding site [chemical binding]; other site 716541010383 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 716541010384 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 716541010385 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 716541010386 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 716541010387 ligand binding site; other site 716541010388 tetramer interface; other site 716541010389 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 716541010390 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 716541010391 inhibitor-cofactor binding pocket; inhibition site 716541010392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541010393 catalytic residue [active] 716541010394 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 716541010395 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 716541010396 NAD(P) binding site [chemical binding]; other site 716541010397 homodimer interface [polypeptide binding]; other site 716541010398 substrate binding site [chemical binding]; other site 716541010399 active site 716541010400 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 716541010401 active site 716541010402 tetramer interface; other site 716541010403 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 716541010404 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 716541010405 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 716541010406 putative ADP-binding pocket [chemical binding]; other site 716541010407 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 716541010408 colanic acid exporter; Provisional; Region: PRK10459 716541010409 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 716541010410 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 716541010411 CoA-binding domain; Region: CoA_binding_3; pfam13727 716541010412 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 716541010413 phosphomannomutase CpsG; Provisional; Region: PRK15414 716541010414 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 716541010415 active site 716541010416 substrate binding site [chemical binding]; other site 716541010417 metal binding site [ion binding]; metal-binding site 716541010418 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 716541010419 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 716541010420 Substrate binding site; other site 716541010421 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 716541010422 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 716541010423 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 716541010424 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 716541010425 active site 716541010426 GDP-Mannose binding site [chemical binding]; other site 716541010427 dimer interface [polypeptide binding]; other site 716541010428 modified nudix motif 716541010429 metal binding site [ion binding]; metal-binding site 716541010430 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 716541010431 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 716541010432 NADP binding site [chemical binding]; other site 716541010433 active site 716541010434 putative substrate binding site [chemical binding]; other site 716541010435 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 716541010436 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 716541010437 NADP-binding site; other site 716541010438 homotetramer interface [polypeptide binding]; other site 716541010439 substrate binding site [chemical binding]; other site 716541010440 homodimer interface [polypeptide binding]; other site 716541010441 active site 716541010442 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 716541010443 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 716541010444 putative trimer interface [polypeptide binding]; other site 716541010445 putative active site [active] 716541010446 putative substrate binding site [chemical binding]; other site 716541010447 putative CoA binding site [chemical binding]; other site 716541010448 putative glycosyl transferase; Provisional; Region: PRK10063 716541010449 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 716541010450 active site 716541010451 putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075 716541010452 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 716541010453 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 716541010454 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 716541010455 putative acyl transferase; Provisional; Region: PRK10191 716541010456 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 716541010457 trimer interface [polypeptide binding]; other site 716541010458 active site 716541010459 substrate binding site [chemical binding]; other site 716541010460 CoA binding site [chemical binding]; other site 716541010461 putative glycosyl transferase; Provisional; Region: PRK10018 716541010462 colanic acid biosynthesis glycosyl transferase WcaA; Region: WcaA; TIGR04017 716541010463 active site 716541010464 tyrosine kinase; Provisional; Region: PRK11519 716541010465 Chain length determinant protein; Region: Wzz; pfam02706 716541010466 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 716541010467 AAA domain; Region: AAA_31; pfam13614 716541010468 Low molecular weight phosphatase family; Region: LMWPc; cd00115 716541010469 active site 716541010470 polysaccharide export protein Wza; Provisional; Region: PRK15078 716541010471 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 716541010472 SLBB domain; Region: SLBB; pfam10531 716541010473 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 716541010474 FOG: CBS domain [General function prediction only]; Region: COG0517 716541010475 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 716541010476 Transporter associated domain; Region: CorC_HlyC; smart01091 716541010477 putative assembly protein; Provisional; Region: PRK10833 716541010478 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 716541010479 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 716541010480 trimer interface [polypeptide binding]; other site 716541010481 active site 716541010482 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 716541010483 ATP-binding site [chemical binding]; other site 716541010484 Sugar specificity; other site 716541010485 Pyrimidine base specificity; other site 716541010486 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 716541010487 putative diguanylate cyclase; Provisional; Region: PRK09776 716541010488 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716541010489 putative active site [active] 716541010490 heme pocket [chemical binding]; other site 716541010491 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716541010492 putative active site [active] 716541010493 heme pocket [chemical binding]; other site 716541010494 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716541010495 putative active site [active] 716541010496 heme pocket [chemical binding]; other site 716541010497 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541010498 metal binding site [ion binding]; metal-binding site 716541010499 active site 716541010500 I-site; other site 716541010501 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 716541010502 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 716541010503 AlkA N-terminal domain; Region: AlkA_N; pfam06029 716541010504 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 716541010505 minor groove reading motif; other site 716541010506 helix-hairpin-helix signature motif; other site 716541010507 substrate binding pocket [chemical binding]; other site 716541010508 active site 716541010509 putative chaperone; Provisional; Region: PRK11678 716541010510 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 716541010511 nucleotide binding site [chemical binding]; other site 716541010512 putative NEF/HSP70 interaction site [polypeptide binding]; other site 716541010513 SBD interface [polypeptide binding]; other site 716541010514 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541010515 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 716541010516 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 716541010517 DNA binding site [nucleotide binding] 716541010518 putative fimbrial protein TcfA; Provisional; Region: PRK15308 716541010519 long tail fiber, proximal subunit; Provisional; Region: 34; PHA02584 716541010520 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 716541010521 Outer membrane usher protein; Region: Usher; pfam00577 716541010522 putative fimbrial protein TcfA; Provisional; Region: PRK15308 716541010523 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 716541010524 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541010525 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541010526 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 716541010527 MMPL family; Region: MMPL; cl14618 716541010528 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 716541010529 MMPL family; Region: MMPL; cl14618 716541010530 MMPL family; Region: MMPL; cl14618 716541010531 putative transporter; Provisional; Region: PRK10504 716541010532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541010533 putative substrate translocation pore; other site 716541010534 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 716541010535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541010536 dimerization interface [polypeptide binding]; other site 716541010537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541010538 dimer interface [polypeptide binding]; other site 716541010539 phosphorylation site [posttranslational modification] 716541010540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541010541 ATP binding site [chemical binding]; other site 716541010542 Mg2+ binding site [ion binding]; other site 716541010543 G-X-G motif; other site 716541010544 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 716541010545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541010546 active site 716541010547 phosphorylation site [posttranslational modification] 716541010548 intermolecular recognition site; other site 716541010549 dimerization interface [polypeptide binding]; other site 716541010550 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541010551 DNA binding site [nucleotide binding] 716541010552 putative protease; Provisional; Region: PRK15452 716541010553 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 716541010554 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 716541010555 lipid kinase; Reviewed; Region: PRK13054 716541010556 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 716541010557 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 716541010558 putative active site; other site 716541010559 catalytic residue [active] 716541010560 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 716541010561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541010562 putative substrate translocation pore; other site 716541010563 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 716541010564 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 716541010565 substrate binding site [chemical binding]; other site 716541010566 ATP binding site [chemical binding]; other site 716541010567 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 716541010568 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541010569 DNA-binding site [nucleotide binding]; DNA binding site 716541010570 UTRA domain; Region: UTRA; pfam07702 716541010571 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 716541010572 dimer interface [polypeptide binding]; other site 716541010573 substrate binding site [chemical binding]; other site 716541010574 ATP binding site [chemical binding]; other site 716541010575 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 716541010576 substrate binding site [chemical binding]; other site 716541010577 multimerization interface [polypeptide binding]; other site 716541010578 ATP binding site [chemical binding]; other site 716541010579 Transposase; Region: HTH_Tnp_1; pfam01527 716541010580 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 716541010581 HTH-like domain; Region: HTH_21; pfam13276 716541010582 Integrase core domain; Region: rve; pfam00665 716541010583 Integrase core domain; Region: rve_3; pfam13683 716541010584 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 716541010585 AAA domain; Region: AAA_22; pfam13401 716541010586 Transcriptional regulators [Transcription]; Region: PurR; COG1609 716541010587 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 716541010588 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 716541010589 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 716541010590 inhibitor-cofactor binding pocket; inhibition site 716541010591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541010592 catalytic residue [active] 716541010593 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 716541010594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541010595 catalytic residue [active] 716541010596 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 716541010597 catalytic residues [active] 716541010598 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541010599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541010600 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 716541010601 dimerization interface [polypeptide binding]; other site 716541010602 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 716541010603 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 716541010604 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 716541010605 active site 716541010606 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 716541010607 Sulfate transporter family; Region: Sulfate_transp; cl19250 716541010608 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 716541010609 Chain length determinant protein; Region: Wzz; pfam02706 716541010610 Exocyst complex component Sec3; Region: Sec3_C; cl19950 716541010611 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 716541010612 AAA domain; Region: AAA_31; pfam13614 716541010613 Low molecular weight phosphatase family; Region: LMWPc; cd00115 716541010614 active site 716541010615 polysaccharide export protein Wza; Provisional; Region: PRK15078 716541010616 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 716541010617 SLBB domain; Region: SLBB; pfam10531 716541010618 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 716541010619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541010620 Coenzyme A binding pocket [chemical binding]; other site 716541010621 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 716541010622 antiporter inner membrane protein; Provisional; Region: PRK11670 716541010623 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 716541010624 Walker A motif; other site 716541010625 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 716541010626 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 716541010627 active site 716541010628 HIGH motif; other site 716541010629 KMSKS motif; other site 716541010630 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 716541010631 tRNA binding surface [nucleotide binding]; other site 716541010632 anticodon binding site; other site 716541010633 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 716541010634 dimer interface [polypeptide binding]; other site 716541010635 putative tRNA-binding site [nucleotide binding]; other site 716541010636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 716541010637 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 716541010638 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 716541010639 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 716541010640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541010641 active site 716541010642 phosphorylation site [posttranslational modification] 716541010643 intermolecular recognition site; other site 716541010644 dimerization interface [polypeptide binding]; other site 716541010645 LytTr DNA-binding domain; Region: LytTR; pfam04397 716541010646 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 716541010647 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 716541010648 GAF domain; Region: GAF; pfam01590 716541010649 Histidine kinase; Region: His_kinase; pfam06580 716541010650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541010651 ATP binding site [chemical binding]; other site 716541010652 Mg2+ binding site [ion binding]; other site 716541010653 G-X-G motif; other site 716541010654 transcriptional regulator MirA; Provisional; Region: PRK15043 716541010655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541010656 dimer interface [polypeptide binding]; other site 716541010657 conserved gate region; other site 716541010658 putative PBP binding loops; other site 716541010659 ABC-ATPase subunit interface; other site 716541010660 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 716541010661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541010662 Walker A/P-loop; other site 716541010663 ATP binding site [chemical binding]; other site 716541010664 Q-loop/lid; other site 716541010665 ABC transporter signature motif; other site 716541010666 Walker B; other site 716541010667 D-loop; other site 716541010668 H-loop/switch region; other site 716541010669 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 716541010670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541010671 dimer interface [polypeptide binding]; other site 716541010672 conserved gate region; other site 716541010673 putative PBP binding loops; other site 716541010674 ABC-ATPase subunit interface; other site 716541010675 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 716541010676 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 716541010677 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 716541010678 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 716541010679 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 716541010680 D-lactate dehydrogenase; Provisional; Region: PRK11183 716541010681 FAD binding domain; Region: FAD_binding_4; cl19922 716541010682 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 716541010683 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 716541010684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541010685 Coenzyme A binding pocket [chemical binding]; other site 716541010686 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 716541010687 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 716541010688 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 716541010689 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 716541010690 oxidoreductase; Provisional; Region: PRK12743 716541010691 classical (c) SDRs; Region: SDR_c; cd05233 716541010692 NAD(P) binding site [chemical binding]; other site 716541010693 active site 716541010694 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 716541010695 Outer membrane efflux protein; Region: OEP; pfam02321 716541010696 Outer membrane efflux protein; Region: OEP; pfam02321 716541010697 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 716541010698 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 716541010699 FMN binding site [chemical binding]; other site 716541010700 active site 716541010701 catalytic residues [active] 716541010702 substrate binding site [chemical binding]; other site 716541010703 hypothetical protein; Provisional; Region: PRK01821 716541010704 hypothetical protein; Provisional; Region: PRK10711 716541010705 cytidine deaminase; Provisional; Region: PRK09027 716541010706 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 716541010707 active site 716541010708 catalytic motif [active] 716541010709 Zn binding site [ion binding]; other site 716541010710 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 716541010711 active site 716541010712 catalytic motif [active] 716541010713 Zn binding site [ion binding]; other site 716541010714 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 716541010715 putative active site [active] 716541010716 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 716541010717 TM-ABC transporter signature motif; other site 716541010718 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 716541010719 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 716541010720 Walker A/P-loop; other site 716541010721 ATP binding site [chemical binding]; other site 716541010722 Q-loop/lid; other site 716541010723 ABC transporter signature motif; other site 716541010724 Walker B; other site 716541010725 D-loop; other site 716541010726 H-loop/switch region; other site 716541010727 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 716541010728 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 716541010729 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 716541010730 ligand binding site [chemical binding]; other site 716541010731 calcium binding site [ion binding]; other site 716541010732 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 716541010733 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541010734 DNA binding site [nucleotide binding] 716541010735 domain linker motif; other site 716541010736 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 716541010737 dimerization interface (closed form) [polypeptide binding]; other site 716541010738 ligand binding site [chemical binding]; other site 716541010739 Predicted membrane protein [Function unknown]; Region: COG2311 716541010740 hypothetical protein; Provisional; Region: PRK10835 716541010741 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 716541010742 active site 716541010743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541010744 putative substrate translocation pore; other site 716541010745 Predicted esterase [General function prediction only]; Region: COG0627 716541010746 S-formylglutathione hydrolase; Region: PLN02442 716541010747 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 716541010748 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 716541010749 N-terminal plug; other site 716541010750 ligand-binding site [chemical binding]; other site 716541010751 lysine transporter; Provisional; Region: PRK10836 716541010752 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 716541010753 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 716541010754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541010755 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 716541010756 putative dimerization interface [polypeptide binding]; other site 716541010757 conserved hypothetical integral membrane protein; Region: TIGR00698 716541010758 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 716541010759 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 716541010760 AP (apurinic/apyrimidinic) site pocket; other site 716541010761 DNA interaction; other site 716541010762 Metal-binding active site; metal-binding site 716541010763 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 716541010764 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 716541010765 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 716541010766 active site 716541010767 P-loop; other site 716541010768 phosphorylation site [posttranslational modification] 716541010769 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 716541010770 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 716541010771 ATP binding site [chemical binding]; other site 716541010772 substrate binding site [chemical binding]; other site 716541010773 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 716541010774 putative substrate binding site [chemical binding]; other site 716541010775 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 716541010776 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 716541010777 active site 716541010778 phosphorylation site [posttranslational modification] 716541010779 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 716541010780 dimerization domain swap beta strand [polypeptide binding]; other site 716541010781 regulatory protein interface [polypeptide binding]; other site 716541010782 active site 716541010783 regulatory phosphorylation site [posttranslational modification]; other site 716541010784 sugar efflux transporter B; Provisional; Region: PRK15011 716541010785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541010786 putative substrate translocation pore; other site 716541010787 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 716541010788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 716541010789 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 716541010790 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 716541010791 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 716541010792 Transposase; Region: HTH_Tnp_1; pfam01527 716541010793 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 716541010794 HTH-like domain; Region: HTH_21; pfam13276 716541010795 Integrase core domain; Region: rve; pfam00665 716541010796 Integrase core domain; Region: rve_3; pfam13683 716541010797 IS2 transposase TnpB; Reviewed; Region: PRK09409 716541010798 HTH-like domain; Region: HTH_21; pfam13276 716541010799 Integrase core domain; Region: rve; pfam00665 716541010800 Integrase core domain; Region: rve_3; pfam13683 716541010801 Transposase; Region: HTH_Tnp_1; cl17663 716541010802 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541010803 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 716541010804 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 716541010805 putative transposase OrfB; Reviewed; Region: PHA02517 716541010806 HTH-like domain; Region: HTH_21; pfam13276 716541010807 Integrase core domain; Region: rve; pfam00665 716541010808 Integrase core domain; Region: rve_2; pfam13333 716541010809 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541010810 Transposase; Region: HTH_Tnp_1; pfam01527 716541010811 elongation factor P; Provisional; Region: PRK04542 716541010812 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 716541010813 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 716541010814 RNA binding site [nucleotide binding]; other site 716541010815 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 716541010816 RNA binding site [nucleotide binding]; other site 716541010817 mannonate dehydratase; Provisional; Region: PRK03906 716541010818 mannonate dehydratase; Region: uxuA; TIGR00695 716541010819 D-mannonate oxidoreductase; Provisional; Region: PRK15037 716541010820 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 716541010821 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 716541010822 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 716541010823 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 716541010824 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 716541010825 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 716541010826 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 716541010827 active site 716541010828 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 716541010829 NlpC/P60 family; Region: NLPC_P60; pfam00877 716541010830 phage resistance protein; Provisional; Region: PRK10551 716541010831 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 716541010832 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541010833 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 716541010834 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 716541010835 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 716541010836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541010837 dimer interface [polypeptide binding]; other site 716541010838 conserved gate region; other site 716541010839 putative PBP binding loops; other site 716541010840 ABC-ATPase subunit interface; other site 716541010841 microcin C ABC transporter permease; Provisional; Region: PRK15021 716541010842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541010843 dimer interface [polypeptide binding]; other site 716541010844 conserved gate region; other site 716541010845 putative PBP binding loops; other site 716541010846 ABC-ATPase subunit interface; other site 716541010847 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 716541010848 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716541010849 Walker A/P-loop; other site 716541010850 ATP binding site [chemical binding]; other site 716541010851 Q-loop/lid; other site 716541010852 ABC transporter signature motif; other site 716541010853 Walker B; other site 716541010854 D-loop; other site 716541010855 H-loop/switch region; other site 716541010856 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 716541010857 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 716541010858 Walker A/P-loop; other site 716541010859 ATP binding site [chemical binding]; other site 716541010860 Q-loop/lid; other site 716541010861 ABC transporter signature motif; other site 716541010862 Walker B; other site 716541010863 D-loop; other site 716541010864 H-loop/switch region; other site 716541010865 hypothetical protein; Provisional; Region: PRK11835 716541010866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541010867 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 716541010868 putative substrate translocation pore; other site 716541010869 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 716541010870 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 716541010871 RNA binding surface [nucleotide binding]; other site 716541010872 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 716541010873 active site 716541010874 uracil binding [chemical binding]; other site 716541010875 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 716541010876 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716541010877 ATP binding site [chemical binding]; other site 716541010878 putative Mg++ binding site [ion binding]; other site 716541010879 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716541010880 nucleotide binding region [chemical binding]; other site 716541010881 ATP-binding site [chemical binding]; other site 716541010882 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 716541010883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 716541010884 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716541010885 Putative lysophospholipase; Region: Hydrolase_4; cl19140 716541010886 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 716541010887 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 716541010888 5S rRNA interface [nucleotide binding]; other site 716541010889 CTC domain interface [polypeptide binding]; other site 716541010890 L16 interface [polypeptide binding]; other site 716541010891 nucleoid-associated protein NdpA; Validated; Region: PRK00378 716541010892 hypothetical protein; Provisional; Region: PRK13689 716541010893 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 716541010894 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 716541010895 Sulfatase; Region: Sulfatase; cl19157 716541010896 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 716541010897 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 716541010898 secondary substrate binding site; other site 716541010899 primary substrate binding site; other site 716541010900 inhibition loop; other site 716541010901 dimerization interface [polypeptide binding]; other site 716541010902 malate:quinone oxidoreductase; Validated; Region: PRK05257 716541010903 Predicted dehydrogenase [General function prediction only]; Region: COG0579 716541010904 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 716541010905 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 716541010906 Sulfate transporter family; Region: Sulfate_transp; cl19250 716541010907 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 716541010908 MgtE intracellular N domain; Region: MgtE_N; smart00924 716541010909 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 716541010910 Divalent cation transporter; Region: MgtE; cl00786 716541010911 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 716541010912 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 716541010913 Walker A/P-loop; other site 716541010914 ATP binding site [chemical binding]; other site 716541010915 Q-loop/lid; other site 716541010916 ABC transporter signature motif; other site 716541010917 Walker B; other site 716541010918 D-loop; other site 716541010919 H-loop/switch region; other site 716541010920 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 716541010921 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 716541010922 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 716541010923 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541010924 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541010925 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 716541010926 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 716541010927 DNA binding site [nucleotide binding] 716541010928 active site 716541010929 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 716541010930 outer membrane porin protein C; Provisional; Region: PRK10554 716541010931 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 716541010932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541010933 ATP binding site [chemical binding]; other site 716541010934 Mg2+ binding site [ion binding]; other site 716541010935 G-X-G motif; other site 716541010936 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 716541010937 putative binding surface; other site 716541010938 active site 716541010939 transcriptional regulator RcsB; Provisional; Region: PRK10840 716541010940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541010941 active site 716541010942 phosphorylation site [posttranslational modification] 716541010943 intermolecular recognition site; other site 716541010944 dimerization interface [polypeptide binding]; other site 716541010945 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541010946 DNA binding residues [nucleotide binding] 716541010947 dimerization interface [polypeptide binding]; other site 716541010948 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 716541010949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541010950 dimer interface [polypeptide binding]; other site 716541010951 phosphorylation site [posttranslational modification] 716541010952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541010953 ATP binding site [chemical binding]; other site 716541010954 Mg2+ binding site [ion binding]; other site 716541010955 G-X-G motif; other site 716541010956 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 716541010957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541010958 active site 716541010959 phosphorylation site [posttranslational modification] 716541010960 intermolecular recognition site; other site 716541010961 dimerization interface [polypeptide binding]; other site 716541010962 DNA gyrase subunit A; Validated; Region: PRK05560 716541010963 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 716541010964 CAP-like domain; other site 716541010965 active site 716541010966 primary dimer interface [polypeptide binding]; other site 716541010967 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 716541010968 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 716541010969 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 716541010970 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 716541010971 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 716541010972 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 716541010973 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 716541010974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541010975 S-adenosylmethionine binding site [chemical binding]; other site 716541010976 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 716541010977 ATP cone domain; Region: ATP-cone; pfam03477 716541010978 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 716541010979 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 716541010980 dimer interface [polypeptide binding]; other site 716541010981 putative radical transfer pathway; other site 716541010982 diiron center [ion binding]; other site 716541010983 tyrosyl radical; other site 716541010984 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 716541010985 catalytic loop [active] 716541010986 iron binding site [ion binding]; other site 716541010987 choline dehydrogenase; Validated; Region: PRK02106 716541010988 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541010989 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541010990 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 716541010991 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 716541010992 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541010993 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 716541010994 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541010995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541010996 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 716541010997 putative effector binding pocket; other site 716541010998 dimerization interface [polypeptide binding]; other site 716541010999 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 716541011000 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 716541011001 active site 716541011002 catalytic site [active] 716541011003 metal binding site [ion binding]; metal-binding site 716541011004 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 716541011005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541011006 putative substrate translocation pore; other site 716541011007 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 716541011008 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541011009 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 716541011010 FAD binding domain; Region: FAD_binding_2; pfam00890 716541011011 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 716541011012 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 716541011013 Cysteine-rich domain; Region: CCG; pfam02754 716541011014 Cysteine-rich domain; Region: CCG; pfam02754 716541011015 hypothetical protein; Provisional; Region: PRK03673 716541011016 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 716541011017 putative MPT binding site; other site 716541011018 Competence-damaged protein; Region: CinA; cl00666 716541011019 YfaZ precursor; Region: YfaZ; pfam07437 716541011020 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 716541011021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 716541011022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541011023 dimer interface [polypeptide binding]; other site 716541011024 phosphorylation site [posttranslational modification] 716541011025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541011026 ATP binding site [chemical binding]; other site 716541011027 Mg2+ binding site [ion binding]; other site 716541011028 G-X-G motif; other site 716541011029 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 716541011030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541011031 active site 716541011032 phosphorylation site [posttranslational modification] 716541011033 intermolecular recognition site; other site 716541011034 dimerization interface [polypeptide binding]; other site 716541011035 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541011036 DNA binding site [nucleotide binding] 716541011037 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 716541011038 Catalytic site [active] 716541011039 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 716541011040 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 716541011041 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 716541011042 Baseplate J-like protein; Region: Baseplate_J; cl01294 716541011043 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 716541011044 RNAse P Rpr2/Rpp21/SNM1 subunit domain; Region: Rpr2; cl00887 716541011045 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 716541011046 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716541011047 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716541011048 catalytic residue [active] 716541011049 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 716541011050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 716541011051 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 716541011052 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 716541011053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 716541011054 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 716541011055 Head fiber protein; Region: Phage_head_fibr; pfam11133 716541011056 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 716541011057 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 716541011058 catalytic residues [active] 716541011059 Antitermination protein; Region: Antiterm; pfam03589 716541011060 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 716541011061 Antitermination protein; Region: Antiterm; pfam03589 716541011062 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 716541011063 NinB protein; Region: NinB; pfam05772 716541011064 putative transposase OrfB; Reviewed; Region: PHA02517 716541011065 HTH-like domain; Region: HTH_21; pfam13276 716541011066 Integrase core domain; Region: rve; pfam00665 716541011067 Integrase core domain; Region: rve_3; pfam13683 716541011068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541011069 Transposase; Region: HTH_Tnp_1; cl17663 716541011070 Predicted transcriptional regulators [Transcription]; Region: ArsR; COG0640 716541011071 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 716541011072 replicative DNA helicase; Region: DnaB; TIGR00665 716541011073 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 716541011074 Walker A motif; other site 716541011075 ATP binding site [chemical binding]; other site 716541011076 Walker B motif; other site 716541011077 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 716541011078 Cro; Region: Cro; pfam09048 716541011079 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 716541011080 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541011081 Transposase; Region: HTH_Tnp_1; pfam01527 716541011082 HTH-like domain; Region: HTH_21; pfam13276 716541011083 Integrase core domain; Region: rve; pfam00665 716541011084 Integrase core domain; Region: rve; pfam00665 716541011085 Integrase core domain; Region: rve_2; pfam13333 716541011086 cIII protein family; Region: cIII; pfam08134 716541011087 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 716541011088 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 716541011089 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 716541011090 Walker A motif; other site 716541011091 ATP binding site [chemical binding]; other site 716541011092 Walker B motif; other site 716541011093 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 716541011094 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 716541011095 ssDNA binding site [nucleotide binding]; other site 716541011096 dimer interface [polypeptide binding]; other site 716541011097 tetramer (dimer of dimers) interface [polypeptide binding]; other site 716541011098 putative single-stranded DNA-binding protein; Region: PHA01740 716541011099 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 716541011100 Protein of unknown function (DUF551); Region: DUF551; pfam04448 716541011101 integrase; Provisional; Region: PRK09692 716541011102 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 716541011103 active site 716541011104 Int/Topo IB signature motif; other site 716541011105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 716541011106 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 716541011107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 716541011108 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 716541011109 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 716541011110 acyl-activating enzyme (AAE) consensus motif; other site 716541011111 putative AMP binding site [chemical binding]; other site 716541011112 putative active site [active] 716541011113 putative CoA binding site [chemical binding]; other site 716541011114 O-succinylbenzoate synthase; Provisional; Region: PRK05105 716541011115 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 716541011116 active site 716541011117 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 716541011118 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 716541011119 substrate binding site [chemical binding]; other site 716541011120 oxyanion hole (OAH) forming residues; other site 716541011121 trimer interface [polypeptide binding]; other site 716541011122 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 716541011123 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 716541011124 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 716541011125 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 716541011126 dimer interface [polypeptide binding]; other site 716541011127 tetramer interface [polypeptide binding]; other site 716541011128 PYR/PP interface [polypeptide binding]; other site 716541011129 TPP binding site [chemical binding]; other site 716541011130 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 716541011131 TPP-binding site; other site 716541011132 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 716541011133 isochorismate synthases; Region: isochor_syn; TIGR00543 716541011134 hypothetical protein; Provisional; Region: PRK10404 716541011135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541011136 Coenzyme A binding pocket [chemical binding]; other site 716541011137 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 716541011138 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 716541011139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541011140 active site 716541011141 phosphorylation site [posttranslational modification] 716541011142 intermolecular recognition site; other site 716541011143 dimerization interface [polypeptide binding]; other site 716541011144 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 716541011145 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 716541011146 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 716541011147 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 716541011148 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 716541011149 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 716541011150 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 716541011151 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 716541011152 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 716541011153 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 716541011154 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 716541011155 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 716541011156 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 716541011157 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 716541011158 NADH dehydrogenase subunit G; Validated; Region: PRK08166 716541011159 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 716541011160 catalytic loop [active] 716541011161 iron binding site [ion binding]; other site 716541011162 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 716541011163 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 716541011164 [4Fe-4S] binding site [ion binding]; other site 716541011165 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 716541011166 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 716541011167 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 716541011168 SLBB domain; Region: SLBB; pfam10531 716541011169 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 716541011170 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 716541011171 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 716541011172 putative dimer interface [polypeptide binding]; other site 716541011173 [2Fe-2S] cluster binding site [ion binding]; other site 716541011174 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 716541011175 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 716541011176 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 716541011177 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 716541011178 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 716541011179 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 716541011180 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541011181 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 716541011182 putative dimerization interface [polypeptide binding]; other site 716541011183 aminotransferase AlaT; Validated; Region: PRK09265 716541011184 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716541011185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541011186 homodimer interface [polypeptide binding]; other site 716541011187 catalytic residue [active] 716541011188 5'-nucleotidase; Provisional; Region: PRK03826 716541011189 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 716541011190 transmembrane helices; other site 716541011191 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 716541011192 TrkA-C domain; Region: TrkA_C; pfam02080 716541011193 TrkA-C domain; Region: TrkA_C; pfam02080 716541011194 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 716541011195 putative phosphatase; Provisional; Region: PRK11587 716541011196 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541011197 active site 716541011198 motif I; other site 716541011199 motif II; other site 716541011200 hypothetical protein; Validated; Region: PRK05445 716541011201 hypothetical protein; Provisional; Region: PRK01816 716541011202 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 716541011203 phosphate acetyltransferase; Reviewed; Region: PRK05632 716541011204 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 716541011205 DRTGG domain; Region: DRTGG; pfam07085 716541011206 phosphate acetyltransferase; Region: pta; TIGR00651 716541011207 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 716541011208 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 716541011209 PYR/PP interface [polypeptide binding]; other site 716541011210 dimer interface [polypeptide binding]; other site 716541011211 TPP binding site [chemical binding]; other site 716541011212 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 716541011213 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 716541011214 TPP-binding site [chemical binding]; other site 716541011215 dimer interface [polypeptide binding]; other site 716541011216 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 716541011217 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 716541011218 active site 716541011219 P-loop; other site 716541011220 phosphorylation site [posttranslational modification] 716541011221 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 716541011222 active site 716541011223 phosphorylation site [posttranslational modification] 716541011224 Transcriptional regulators [Transcription]; Region: PurR; COG1609 716541011225 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541011226 DNA binding site [nucleotide binding] 716541011227 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 716541011228 putative dimerization interface [polypeptide binding]; other site 716541011229 putative ligand binding site [chemical binding]; other site 716541011230 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 716541011231 nudix motif; other site 716541011232 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 716541011233 active site 716541011234 metal binding site [ion binding]; metal-binding site 716541011235 homotetramer interface [polypeptide binding]; other site 716541011236 glutathione S-transferase; Provisional; Region: PRK15113 716541011237 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 716541011238 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 716541011239 N-terminal domain interface [polypeptide binding]; other site 716541011240 putative dimer interface [polypeptide binding]; other site 716541011241 putative substrate binding pocket (H-site) [chemical binding]; other site 716541011242 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 716541011243 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 716541011244 C-terminal domain interface [polypeptide binding]; other site 716541011245 GSH binding site (G-site) [chemical binding]; other site 716541011246 dimer interface [polypeptide binding]; other site 716541011247 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 716541011248 N-terminal domain interface [polypeptide binding]; other site 716541011249 putative dimer interface [polypeptide binding]; other site 716541011250 active site 716541011251 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 716541011252 homooctamer interface [polypeptide binding]; other site 716541011253 active site 716541011254 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 716541011255 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 716541011256 putative NAD(P) binding site [chemical binding]; other site 716541011257 putative active site [active] 716541011258 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 716541011259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541011260 Coenzyme A binding pocket [chemical binding]; other site 716541011261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 716541011262 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 716541011263 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 716541011264 Walker A/P-loop; other site 716541011265 ATP binding site [chemical binding]; other site 716541011266 Q-loop/lid; other site 716541011267 ABC transporter signature motif; other site 716541011268 Walker B; other site 716541011269 D-loop; other site 716541011270 H-loop/switch region; other site 716541011271 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 716541011272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541011273 dimer interface [polypeptide binding]; other site 716541011274 conserved gate region; other site 716541011275 putative PBP binding loops; other site 716541011276 ABC-ATPase subunit interface; other site 716541011277 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 716541011278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541011279 dimer interface [polypeptide binding]; other site 716541011280 conserved gate region; other site 716541011281 putative PBP binding loops; other site 716541011282 ABC-ATPase subunit interface; other site 716541011283 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 716541011284 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541011285 substrate binding pocket [chemical binding]; other site 716541011286 membrane-bound complex binding site; other site 716541011287 hinge residues; other site 716541011288 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 716541011289 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541011290 substrate binding pocket [chemical binding]; other site 716541011291 membrane-bound complex binding site; other site 716541011292 hinge residues; other site 716541011293 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 716541011294 amidophosphoribosyltransferase; Provisional; Region: PRK09246 716541011295 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 716541011296 active site 716541011297 tetramer interface [polypeptide binding]; other site 716541011298 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 716541011299 active site 716541011300 colicin V production protein; Provisional; Region: PRK10845 716541011301 cell division protein DedD; Provisional; Region: PRK11633 716541011302 Sporulation related domain; Region: SPOR; pfam05036 716541011303 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 716541011304 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 716541011305 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 716541011306 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 716541011307 hypothetical protein; Provisional; Region: PRK10847 716541011308 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 716541011309 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 716541011310 dimerization interface 3.5A [polypeptide binding]; other site 716541011311 active site 716541011312 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 716541011313 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 716541011314 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 716541011315 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 716541011316 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 716541011317 ligand binding site [chemical binding]; other site 716541011318 NAD binding site [chemical binding]; other site 716541011319 catalytic site [active] 716541011320 homodimer interface [polypeptide binding]; other site 716541011321 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 716541011322 putative transporter; Provisional; Region: PRK12382 716541011323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541011324 putative substrate translocation pore; other site 716541011325 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 716541011326 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 716541011327 dimer interface [polypeptide binding]; other site 716541011328 active site 716541011329 Uncharacterized conserved protein [Function unknown]; Region: COG4121 716541011330 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 716541011331 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 716541011332 YfcL protein; Region: YfcL; pfam08891 716541011333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 716541011334 hypothetical protein; Provisional; Region: PRK10621 716541011335 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 716541011336 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 716541011337 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 716541011338 Tetramer interface [polypeptide binding]; other site 716541011339 active site 716541011340 FMN-binding site [chemical binding]; other site 716541011341 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805 716541011342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541011343 S-adenosylmethionine binding site [chemical binding]; other site 716541011344 hypothetical protein; Provisional; Region: PRK04946 716541011345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 716541011346 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 716541011347 catalytic core [active] 716541011348 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 716541011349 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 716541011350 substrate binding site [chemical binding]; other site 716541011351 oxyanion hole (OAH) forming residues; other site 716541011352 trimer interface [polypeptide binding]; other site 716541011353 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 716541011354 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 716541011355 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 716541011356 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 716541011357 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 716541011358 dimer interface [polypeptide binding]; other site 716541011359 active site 716541011360 conserved hypothetical protein; Region: TIGR00743 716541011361 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 716541011362 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 716541011363 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 716541011364 integrase; Provisional; Region: PRK09692 716541011365 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 716541011366 active site 716541011367 Int/Topo IB signature motif; other site 716541011368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541011369 Transposase; Region: HTH_Tnp_1; pfam01527 716541011370 lac repressor; Reviewed; Region: lacI; PRK09526 716541011371 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541011372 DNA binding site [nucleotide binding] 716541011373 domain linker motif; other site 716541011374 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 716541011375 ligand binding site [chemical binding]; other site 716541011376 dimerization interface (open form) [polypeptide binding]; other site 716541011377 dimerization interface (closed form) [polypeptide binding]; other site 716541011378 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 716541011379 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 716541011380 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 716541011381 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 716541011382 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 716541011383 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 716541011384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541011385 putative substrate translocation pore; other site 716541011386 Maltose acetyltransferase; Region: Mac; pfam12464 716541011387 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 716541011388 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 716541011389 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 716541011390 putative dimer interface [polypeptide binding]; other site 716541011391 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 716541011392 Clp amino terminal domain; Region: Clp_N; pfam02861 716541011393 Clp amino terminal domain; Region: Clp_N; pfam02861 716541011394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541011395 Walker A motif; other site 716541011396 ATP binding site [chemical binding]; other site 716541011397 Walker B motif; other site 716541011398 arginine finger; other site 716541011399 CHD5-like protein; Region: CHD5; pfam04420 716541011400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541011401 Walker A motif; other site 716541011402 ATP binding site [chemical binding]; other site 716541011403 Walker B motif; other site 716541011404 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 716541011405 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 716541011406 Peptidase family M48; Region: Peptidase_M48; cl12018 716541011407 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 716541011408 HTH-like domain; Region: HTH_21; pfam13276 716541011409 Integrase core domain; Region: rve; pfam00665 716541011410 Integrase core domain; Region: rve_2; pfam13333 716541011411 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 716541011412 HTH-like domain; Region: HTH_21; pfam13276 716541011413 Integrase core domain; Region: rve; pfam00665 716541011414 Integrase core domain; Region: rve_3; pfam13683 716541011415 Transposase; Region: HTH_Tnp_1; pfam01527 716541011416 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 716541011417 Predicted GTPase [General function prediction only]; Region: COG3596 716541011418 YfjP GTPase; Region: YfjP; cd11383 716541011419 G1 box; other site 716541011420 GTP/Mg2+ binding site [chemical binding]; other site 716541011421 Switch I region; other site 716541011422 G2 box; other site 716541011423 Switch II region; other site 716541011424 G3 box; other site 716541011425 G4 box; other site 716541011426 G5 box; other site 716541011427 Predicted transcriptional regulator [Transcription]; Region: COG2378 716541011428 HTH domain; Region: HTH_11; cl17392 716541011429 WYL domain; Region: WYL; pfam13280 716541011430 Domain of unknown function (DUF932); Region: DUF932; pfam06067 716541011431 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 716541011432 Antirestriction protein; Region: Antirestrict; pfam03230 716541011433 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 716541011434 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 716541011435 MPN+ (JAMM) motif; other site 716541011436 Zinc-binding site [ion binding]; other site 716541011437 Protein of unknown function (DUF987); Region: DUF987; pfam06174 716541011438 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 716541011439 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 716541011440 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 716541011441 heme-binding site [chemical binding]; other site 716541011442 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541011443 metal binding site [ion binding]; metal-binding site 716541011444 active site 716541011445 I-site; other site 716541011446 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 716541011447 putative acyl-acceptor binding pocket; other site 716541011448 aminotransferase; Validated; Region: PRK08175 716541011449 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716541011450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541011451 homodimer interface [polypeptide binding]; other site 716541011452 catalytic residue [active] 716541011453 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 716541011454 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 716541011455 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 716541011456 Histidine kinase; Region: His_kinase; pfam06580 716541011457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541011458 ATP binding site [chemical binding]; other site 716541011459 Mg2+ binding site [ion binding]; other site 716541011460 G-X-G motif; other site 716541011461 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 716541011462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541011463 active site 716541011464 phosphorylation site [posttranslational modification] 716541011465 intermolecular recognition site; other site 716541011466 dimerization interface [polypeptide binding]; other site 716541011467 LytTr DNA-binding domain; Region: LytTR; pfam04397 716541011468 glucokinase; Provisional; Region: glk; PRK00292 716541011469 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 716541011470 nucleotide binding site [chemical binding]; other site 716541011471 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 716541011472 Cl- selectivity filter; other site 716541011473 Cl- binding residues [ion binding]; other site 716541011474 pore gating glutamate residue; other site 716541011475 dimer interface [polypeptide binding]; other site 716541011476 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 716541011477 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 716541011478 dimer interface [polypeptide binding]; other site 716541011479 PYR/PP interface [polypeptide binding]; other site 716541011480 TPP binding site [chemical binding]; other site 716541011481 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 716541011482 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 716541011483 TPP-binding site [chemical binding]; other site 716541011484 dimer interface [polypeptide binding]; other site 716541011485 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 716541011486 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 716541011487 active site 716541011488 catalytic tetrad [active] 716541011489 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 716541011490 manganese transport protein MntH; Reviewed; Region: PRK00701 716541011491 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 716541011492 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 716541011493 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 716541011494 Nucleoside recognition; Region: Gate; pfam07670 716541011495 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 716541011496 MASE1; Region: MASE1; cl17823 716541011497 diguanylate cyclase; Region: GGDEF; smart00267 716541011498 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541011499 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 716541011500 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 716541011501 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 716541011502 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 716541011503 active site 716541011504 HIGH motif; other site 716541011505 KMSKS motif; other site 716541011506 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 716541011507 FlxA-like protein; Region: FlxA; pfam14282 716541011508 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541011509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541011510 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 716541011511 putative dimerization interface [polypeptide binding]; other site 716541011512 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 716541011513 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 716541011514 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 716541011515 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 716541011516 nucleotide binding pocket [chemical binding]; other site 716541011517 K-X-D-G motif; other site 716541011518 catalytic site [active] 716541011519 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 716541011520 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 716541011521 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 716541011522 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 716541011523 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 716541011524 Dimer interface [polypeptide binding]; other site 716541011525 cell division protein ZipA; Provisional; Region: PRK03427 716541011526 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 716541011527 FtsZ protein binding site [polypeptide binding]; other site 716541011528 putative sulfate transport protein CysZ; Validated; Region: PRK04949 716541011529 cysteine synthase; Region: PLN02565 716541011530 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 716541011531 dimer interface [polypeptide binding]; other site 716541011532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541011533 catalytic residue [active] 716541011534 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 716541011535 dimerization domain swap beta strand [polypeptide binding]; other site 716541011536 regulatory protein interface [polypeptide binding]; other site 716541011537 active site 716541011538 regulatory phosphorylation site [posttranslational modification]; other site 716541011539 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 716541011540 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 716541011541 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 716541011542 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 716541011543 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 716541011544 HPr interaction site; other site 716541011545 glycerol kinase (GK) interaction site [polypeptide binding]; other site 716541011546 active site 716541011547 phosphorylation site [posttranslational modification] 716541011548 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 716541011549 dimer interface [polypeptide binding]; other site 716541011550 pyridoxal binding site [chemical binding]; other site 716541011551 ATP binding site [chemical binding]; other site 716541011552 cysteine synthase; Region: PLN02565 716541011553 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 716541011554 dimer interface [polypeptide binding]; other site 716541011555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541011556 catalytic residue [active] 716541011557 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 716541011558 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 716541011559 Walker A/P-loop; other site 716541011560 ATP binding site [chemical binding]; other site 716541011561 Q-loop/lid; other site 716541011562 ABC transporter signature motif; other site 716541011563 Walker B; other site 716541011564 D-loop; other site 716541011565 H-loop/switch region; other site 716541011566 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 716541011567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541011568 dimer interface [polypeptide binding]; other site 716541011569 conserved gate region; other site 716541011570 putative PBP binding loops; other site 716541011571 ABC-ATPase subunit interface; other site 716541011572 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 716541011573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541011574 dimer interface [polypeptide binding]; other site 716541011575 conserved gate region; other site 716541011576 putative PBP binding loops; other site 716541011577 ABC-ATPase subunit interface; other site 716541011578 thiosulfate transporter subunit; Provisional; Region: PRK10852 716541011579 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 716541011580 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 716541011581 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 716541011582 putative acetyltransferase; Provisional; Region: PRK03624 716541011583 Uncharacterized conserved protein [Function unknown]; Region: COG3375 716541011584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541011585 Coenzyme A binding pocket [chemical binding]; other site 716541011586 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 716541011587 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 716541011588 active site 716541011589 metal binding site [ion binding]; metal-binding site 716541011590 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 716541011591 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 716541011592 Malic enzyme, N-terminal domain; Region: malic; pfam00390 716541011593 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 716541011594 putative NAD(P) binding site [chemical binding]; other site 716541011595 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 716541011596 transaldolase-like protein; Provisional; Region: PTZ00411 716541011597 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 716541011598 active site 716541011599 dimer interface [polypeptide binding]; other site 716541011600 catalytic residue [active] 716541011601 transketolase; Reviewed; Region: PRK12753 716541011602 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 716541011603 TPP-binding site [chemical binding]; other site 716541011604 dimer interface [polypeptide binding]; other site 716541011605 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 716541011606 PYR/PP interface [polypeptide binding]; other site 716541011607 dimer interface [polypeptide binding]; other site 716541011608 TPP binding site [chemical binding]; other site 716541011609 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 716541011610 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 716541011611 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 716541011612 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 716541011613 dimer interface [polypeptide binding]; other site 716541011614 ADP-ribose binding site [chemical binding]; other site 716541011615 active site 716541011616 nudix motif; other site 716541011617 metal binding site [ion binding]; metal-binding site 716541011618 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 716541011619 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 716541011620 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 716541011621 hypothetical protein; Provisional; Region: PRK07236 716541011622 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 716541011623 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716541011624 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 716541011625 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 716541011626 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541011627 dimerization interface [polypeptide binding]; other site 716541011628 Histidine kinase; Region: HisKA_3; pfam07730 716541011629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541011630 ATP binding site [chemical binding]; other site 716541011631 Mg2+ binding site [ion binding]; other site 716541011632 G-X-G motif; other site 716541011633 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 716541011634 MMPL family; Region: MMPL; cl14618 716541011635 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 716541011636 putative catalytic residues [active] 716541011637 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 716541011638 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 716541011639 metal binding site [ion binding]; metal-binding site 716541011640 dimer interface [polypeptide binding]; other site 716541011641 hypothetical protein; Provisional; Region: PRK13664 716541011642 putative hydrolase; Provisional; Region: PRK11460 716541011643 Predicted esterase [General function prediction only]; Region: COG0400 716541011644 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 716541011645 Helicase; Region: Helicase_RecD; pfam05127 716541011646 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 716541011647 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 716541011648 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 716541011649 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 716541011650 ATP binding site [chemical binding]; other site 716541011651 active site 716541011652 substrate binding site [chemical binding]; other site 716541011653 lipoprotein; Provisional; Region: PRK11679 716541011654 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 716541011655 dimer interface [polypeptide binding]; other site 716541011656 active site 716541011657 catalytic residue [active] 716541011658 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 716541011659 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 716541011660 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 716541011661 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 716541011662 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 716541011663 catalytic triad [active] 716541011664 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 716541011665 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 716541011666 Peptidase family M48; Region: Peptidase_M48; cl12018 716541011667 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 716541011668 catalytic residues [active] 716541011669 Winged helix-turn helix; Region: HTH_29; pfam13551 716541011670 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 716541011671 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 716541011672 active site 716541011673 dimer interface [polypeptide binding]; other site 716541011674 catalytic nucleophile [active] 716541011675 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 716541011676 interface (dimer of trimers) [polypeptide binding]; other site 716541011677 Substrate-binding/catalytic site; other site 716541011678 Zn-binding sites [ion binding]; other site 716541011679 DNA replication initiation factor; Provisional; Region: PRK08084 716541011680 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 716541011681 uracil transporter; Provisional; Region: PRK10720 716541011682 uracil-xanthine permease; Region: ncs2; TIGR00801 716541011683 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 716541011684 active site 716541011685 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 716541011686 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 716541011687 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 716541011688 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 716541011689 nucleotide binding site [chemical binding]; other site 716541011690 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 716541011691 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 716541011692 dimerization interface [polypeptide binding]; other site 716541011693 putative ATP binding site [chemical binding]; other site 716541011694 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 716541011695 active site 716541011696 substrate binding site [chemical binding]; other site 716541011697 cosubstrate binding site; other site 716541011698 catalytic site [active] 716541011699 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 716541011700 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 716541011701 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 716541011702 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 716541011703 domain interface [polypeptide binding]; other site 716541011704 active site 716541011705 catalytic site [active] 716541011706 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 716541011707 domain interface [polypeptide binding]; other site 716541011708 active site 716541011709 catalytic site [active] 716541011710 exopolyphosphatase; Provisional; Region: PRK10854 716541011711 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 716541011712 MASE1; Region: MASE1; cl17823 716541011713 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 716541011714 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541011715 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 716541011716 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 716541011717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716541011718 NAD(P) binding site [chemical binding]; other site 716541011719 active site 716541011720 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 716541011721 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 716541011722 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 716541011723 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 716541011724 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 716541011725 substrate binding site [chemical binding]; other site 716541011726 ATP binding site [chemical binding]; other site 716541011727 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 716541011728 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 716541011729 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 716541011730 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 716541011731 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 716541011732 TM-ABC transporter signature motif; other site 716541011733 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 716541011734 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 716541011735 Walker A/P-loop; other site 716541011736 ATP binding site [chemical binding]; other site 716541011737 Q-loop/lid; other site 716541011738 ABC transporter signature motif; other site 716541011739 Walker B; other site 716541011740 D-loop; other site 716541011741 H-loop/switch region; other site 716541011742 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 716541011743 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 716541011744 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 716541011745 ligand binding site [chemical binding]; other site 716541011746 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 716541011747 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 716541011748 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 716541011749 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 716541011750 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 716541011751 PYR/PP interface [polypeptide binding]; other site 716541011752 dimer interface [polypeptide binding]; other site 716541011753 TPP binding site [chemical binding]; other site 716541011754 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 716541011755 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 716541011756 TPP-binding site; other site 716541011757 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 716541011758 tetrameric interface [polypeptide binding]; other site 716541011759 NAD binding site [chemical binding]; other site 716541011760 catalytic residues [active] 716541011761 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 716541011762 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 716541011763 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 716541011764 putative active site [active] 716541011765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 716541011766 HTH-like domain; Region: HTH_21; pfam13276 716541011767 Integrase core domain; Region: rve; pfam00665 716541011768 Integrase core domain; Region: rve_3; pfam13683 716541011769 Transposase; Region: HTH_Tnp_1; pfam01527 716541011770 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 716541011771 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 716541011772 substrate binding pocket [chemical binding]; other site 716541011773 dimer interface [polypeptide binding]; other site 716541011774 inhibitor binding site; inhibition site 716541011775 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 716541011776 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 716541011777 Putative transposase; Region: Y2_Tnp; pfam04986 716541011778 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 716541011779 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 716541011780 catalytic residues [active] 716541011781 catalytic nucleophile [active] 716541011782 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 716541011783 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 716541011784 Transposase; Region: DEDD_Tnp_IS110; pfam01548 716541011785 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 716541011786 putative transcriptional regulator MerR; Provisional; Region: PRK13752 716541011787 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 716541011788 DNA binding residues [nucleotide binding] 716541011789 dimer interface [polypeptide binding]; other site 716541011790 mercury binding site [ion binding]; other site 716541011791 putative mercuric transport protein; Provisional; Region: PRK13751 716541011792 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 716541011793 metal-binding site [ion binding] 716541011794 Membrane transport protein MerF; Region: Transport_MerF; pfam11431 716541011795 putative mercuric reductase; Provisional; Region: PRK13748 716541011796 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 716541011797 metal-binding site [ion binding] 716541011798 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716541011799 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 716541011800 transcriptional regulator MerD; Provisional; Region: PRK13749 716541011801 Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111 716541011802 DNA binding residues [nucleotide binding] 716541011803 putative dimer interface [polypeptide binding]; other site 716541011804 putative mercury resistance protein; Provisional; Region: PRK13747 716541011805 multiple promoter invertase; Provisional; Region: mpi; PRK13413 716541011806 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 716541011807 catalytic residues [active] 716541011808 catalytic nucleophile [active] 716541011809 Presynaptic Site I dimer interface [polypeptide binding]; other site 716541011810 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 716541011811 Synaptic Flat tetramer interface [polypeptide binding]; other site 716541011812 Synaptic Site I dimer interface [polypeptide binding]; other site 716541011813 DNA binding site [nucleotide binding] 716541011814 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 716541011815 DNA-binding interface [nucleotide binding]; DNA binding site 716541011816 TniQ; Region: TniQ; pfam06527 716541011817 Bacterial TniB protein; Region: TniB; pfam05621 716541011818 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 716541011819 Integrase core domain; Region: rve; pfam00665 716541011820 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 716541011821 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716541011822 putative DNA binding site [nucleotide binding]; other site 716541011823 putative Zn2+ binding site [ion binding]; other site 716541011824 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 716541011825 Low molecular weight phosphatase family; Region: LMWPc; cd00115 716541011826 active site 716541011827 Sodium Bile acid symporter family; Region: SBF; cl19217 716541011828 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 716541011829 entry exclusion lipoprotein TrbK; Region: TrbK_RP4; TIGR04359 716541011830 conjugal transfer protein TrbJ; Provisional; Region: PRK13879 716541011831 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 716541011832 Replication initiator protein A; Region: RPA; cl19398 716541011833 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 716541011834 integrase; Provisional; Region: PRK09692 716541011835 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 716541011836 active site 716541011837 Int/Topo IB signature motif; other site 716541011838 GMP synthase; Reviewed; Region: guaA; PRK00074 716541011839 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 716541011840 AMP/PPi binding site [chemical binding]; other site 716541011841 candidate oxyanion hole; other site 716541011842 catalytic triad [active] 716541011843 potential glutamine specificity residues [chemical binding]; other site 716541011844 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 716541011845 ATP Binding subdomain [chemical binding]; other site 716541011846 Ligand Binding sites [chemical binding]; other site 716541011847 Dimerization subdomain; other site 716541011848 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 716541011849 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 716541011850 active site 716541011851 Domain in cystathionine beta-synthase and other proteins; Region: CBS; smart00116 716541011852 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 716541011853 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 716541011854 generic binding surface II; other site 716541011855 generic binding surface I; other site 716541011856 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 716541011857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541011858 putative substrate translocation pore; other site 716541011859 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 716541011860 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 716541011861 active site 716541011862 Zn binding site [ion binding]; other site 716541011863 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 716541011864 zinc-ribbons; Region: zinc-ribbons_6; pfam07191 716541011865 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 716541011866 POT family; Region: PTR2; cl17359 716541011867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541011868 putative substrate translocation pore; other site 716541011869 GTP-binding protein Der; Reviewed; Region: PRK00093 716541011870 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 716541011871 G1 box; other site 716541011872 GTP/Mg2+ binding site [chemical binding]; other site 716541011873 Switch I region; other site 716541011874 G2 box; other site 716541011875 Switch II region; other site 716541011876 G3 box; other site 716541011877 G4 box; other site 716541011878 G5 box; other site 716541011879 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 716541011880 G1 box; other site 716541011881 GTP/Mg2+ binding site [chemical binding]; other site 716541011882 Switch I region; other site 716541011883 G2 box; other site 716541011884 G3 box; other site 716541011885 Switch II region; other site 716541011886 G4 box; other site 716541011887 G5 box; other site 716541011888 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 716541011889 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 716541011890 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 716541011891 Trp docking motif [polypeptide binding]; other site 716541011892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 716541011893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 716541011894 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 716541011895 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 716541011896 dimer interface [polypeptide binding]; other site 716541011897 motif 1; other site 716541011898 active site 716541011899 motif 2; other site 716541011900 motif 3; other site 716541011901 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 716541011902 anticodon binding site; other site 716541011903 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 716541011904 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 716541011905 cytoskeletal protein RodZ; Provisional; Region: PRK10856 716541011906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541011907 non-specific DNA binding site [nucleotide binding]; other site 716541011908 salt bridge; other site 716541011909 sequence-specific DNA binding site [nucleotide binding]; other site 716541011910 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 716541011911 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 716541011912 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716541011913 FeS/SAM binding site; other site 716541011914 Nucleoside diphosphate kinase; Region: NDK; pfam00334 716541011915 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 716541011916 active site 716541011917 multimer interface [polypeptide binding]; other site 716541011918 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 716541011919 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 716541011920 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 716541011921 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 716541011922 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 716541011923 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 716541011924 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 716541011925 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 716541011926 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 716541011927 putative [Fe4-S4] binding site [ion binding]; other site 716541011928 putative molybdopterin cofactor binding site [chemical binding]; other site 716541011929 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 716541011930 putative molybdopterin cofactor binding site; other site 716541011931 penicillin-binding protein 1C; Provisional; Region: PRK11240 716541011932 Transglycosylase; Region: Transgly; pfam00912 716541011933 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 716541011934 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 716541011935 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 716541011936 MG2 domain; Region: A2M_N; pfam01835 716541011937 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 716541011938 Alpha-2-macroglobulin family; Region: A2M; pfam00207 716541011939 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 716541011940 surface patch; other site 716541011941 thioester region; other site 716541011942 specificity defining residues; other site 716541011943 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 716541011944 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 716541011945 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 716541011946 active site turn [active] 716541011947 phosphorylation site [posttranslational modification] 716541011948 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 716541011949 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 716541011950 NAD binding site [chemical binding]; other site 716541011951 sugar binding site [chemical binding]; other site 716541011952 divalent metal binding site [ion binding]; other site 716541011953 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 716541011954 dimer interface [polypeptide binding]; other site 716541011955 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 716541011956 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 716541011957 active site residue [active] 716541011958 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 716541011959 active site residue [active] 716541011960 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 716541011961 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 716541011962 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 716541011963 putative active site [active] 716541011964 SseB protein N-terminal domain; Region: SseB; pfam07179 716541011965 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 716541011966 SseB protein C-terminal domain; Region: SseB_C; pfam14581 716541011967 aminopeptidase B; Provisional; Region: PRK05015 716541011968 Peptidase; Region: DUF3663; pfam12404 716541011969 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 716541011970 interface (dimer of trimers) [polypeptide binding]; other site 716541011971 Substrate-binding/catalytic site; other site 716541011972 Zn-binding sites [ion binding]; other site 716541011973 hypothetical protein; Provisional; Region: PRK10721 716541011974 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 716541011975 catalytic loop [active] 716541011976 iron binding site [ion binding]; other site 716541011977 chaperone protein HscA; Provisional; Region: hscA; PRK05183 716541011978 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 716541011979 nucleotide binding site [chemical binding]; other site 716541011980 putative NEF/HSP70 interaction site [polypeptide binding]; other site 716541011981 SBD interface [polypeptide binding]; other site 716541011982 co-chaperone HscB; Provisional; Region: hscB; PRK05014 716541011983 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 716541011984 HSP70 interaction site [polypeptide binding]; other site 716541011985 HSCB C-terminal oligomerization domain; Region: HSCB_C; pfam07743 716541011986 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 716541011987 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 716541011988 trimerization site [polypeptide binding]; other site 716541011989 active site 716541011990 cysteine desulfurase; Provisional; Region: PRK14012 716541011991 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 716541011992 catalytic residue [active] 716541011993 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 716541011994 Rrf2 family protein; Region: rrf2_super; TIGR00738 716541011995 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 716541011996 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 716541011997 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 716541011998 active site 716541011999 dimerization interface [polypeptide binding]; other site 716541012000 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 716541012001 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 716541012002 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 716541012003 PRD domain; Region: PRD; pfam00874 716541012004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541012005 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 716541012006 putative substrate translocation pore; other site 716541012007 Predicted membrane protein [Function unknown]; Region: COG2259 716541012008 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 716541012009 dimer interface [polypeptide binding]; other site 716541012010 active site 716541012011 glycine-pyridoxal phosphate binding site [chemical binding]; other site 716541012012 folate binding site [chemical binding]; other site 716541012013 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 716541012014 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 716541012015 heme-binding site [chemical binding]; other site 716541012016 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 716541012017 FAD binding pocket [chemical binding]; other site 716541012018 FAD binding motif [chemical binding]; other site 716541012019 phosphate binding motif [ion binding]; other site 716541012020 beta-alpha-beta structure motif; other site 716541012021 NAD binding pocket [chemical binding]; other site 716541012022 Heme binding pocket [chemical binding]; other site 716541012023 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 716541012024 response regulator GlrR; Provisional; Region: PRK15115 716541012025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541012026 active site 716541012027 phosphorylation site [posttranslational modification] 716541012028 intermolecular recognition site; other site 716541012029 dimerization interface [polypeptide binding]; other site 716541012030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541012031 Walker A motif; other site 716541012032 ATP binding site [chemical binding]; other site 716541012033 Walker B motif; other site 716541012034 arginine finger; other site 716541012035 hypothetical protein; Provisional; Region: PRK10722 716541012036 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 716541012037 HAMP domain; Region: HAMP; pfam00672 716541012038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541012039 dimer interface [polypeptide binding]; other site 716541012040 phosphorylation site [posttranslational modification] 716541012041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541012042 ATP binding site [chemical binding]; other site 716541012043 Mg2+ binding site [ion binding]; other site 716541012044 G-X-G motif; other site 716541012045 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 716541012046 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 716541012047 dimerization interface [polypeptide binding]; other site 716541012048 ATP binding site [chemical binding]; other site 716541012049 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 716541012050 dimerization interface [polypeptide binding]; other site 716541012051 ATP binding site [chemical binding]; other site 716541012052 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 716541012053 putative active site [active] 716541012054 catalytic triad [active] 716541012055 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 716541012056 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541012057 substrate binding pocket [chemical binding]; other site 716541012058 membrane-bound complex binding site; other site 716541012059 hinge residues; other site 716541012060 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716541012061 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716541012062 catalytic residue [active] 716541012063 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 716541012064 nucleoside/Zn binding site; other site 716541012065 dimer interface [polypeptide binding]; other site 716541012066 catalytic motif [active] 716541012067 hypothetical protein; Provisional; Region: PRK11590 716541012068 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 716541012069 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 716541012070 active site turn [active] 716541012071 phosphorylation site [posttranslational modification] 716541012072 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 716541012073 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 716541012074 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 716541012075 putative active site [active] 716541012076 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 716541012077 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 716541012078 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 716541012079 putative active site [active] 716541012080 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 716541012081 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 716541012082 active site 716541012083 hydrophilic channel; other site 716541012084 dimerization interface [polypeptide binding]; other site 716541012085 catalytic residues [active] 716541012086 active site lid [active] 716541012087 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 716541012088 Recombination protein O N terminal; Region: RecO_N; pfam11967 716541012089 Recombination protein O C terminal; Region: RecO_C; pfam02565 716541012090 GTPase Era; Reviewed; Region: era; PRK00089 716541012091 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 716541012092 G1 box; other site 716541012093 GTP/Mg2+ binding site [chemical binding]; other site 716541012094 Switch I region; other site 716541012095 G2 box; other site 716541012096 Switch II region; other site 716541012097 G3 box; other site 716541012098 G4 box; other site 716541012099 G5 box; other site 716541012100 KH domain; Region: KH_2; pfam07650 716541012101 ribonuclease III; Reviewed; Region: rnc; PRK00102 716541012102 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 716541012103 dimerization interface [polypeptide binding]; other site 716541012104 active site 716541012105 metal binding site [ion binding]; metal-binding site 716541012106 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 716541012107 dsRNA binding site [nucleotide binding]; other site 716541012108 signal peptidase I; Provisional; Region: PRK10861 716541012109 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 716541012110 Catalytic site [active] 716541012111 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 716541012112 GTP-binding protein LepA; Provisional; Region: PRK05433 716541012113 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 716541012114 G1 box; other site 716541012115 putative GEF interaction site [polypeptide binding]; other site 716541012116 GTP/Mg2+ binding site [chemical binding]; other site 716541012117 Switch I region; other site 716541012118 G2 box; other site 716541012119 G3 box; other site 716541012120 Switch II region; other site 716541012121 G4 box; other site 716541012122 G5 box; other site 716541012123 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 716541012124 Elongation Factor G, domain II; Region: EFG_II; pfam14492 716541012125 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 716541012126 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 716541012127 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 716541012128 anti-sigma E factor; Provisional; Region: rseB; PRK09455 716541012129 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 716541012130 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 716541012131 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 716541012132 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 716541012133 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 716541012134 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 716541012135 DNA binding residues [nucleotide binding] 716541012136 L-aspartate oxidase; Provisional; Region: PRK09077 716541012137 L-aspartate oxidase; Provisional; Region: PRK06175 716541012138 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 716541012139 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 716541012140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541012141 S-adenosylmethionine binding site [chemical binding]; other site 716541012142 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 716541012143 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 716541012144 ATP binding site [chemical binding]; other site 716541012145 Mg++ binding site [ion binding]; other site 716541012146 motif III; other site 716541012147 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716541012148 nucleotide binding region [chemical binding]; other site 716541012149 ATP-binding site [chemical binding]; other site 716541012150 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 716541012151 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 716541012152 ligand binding site [chemical binding]; other site 716541012153 active site 716541012154 UGI interface [polypeptide binding]; other site 716541012155 catalytic site [active] 716541012156 putative methyltransferase; Provisional; Region: PRK10864 716541012157 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 716541012158 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 716541012159 thioredoxin 2; Provisional; Region: PRK10996 716541012160 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 716541012161 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 716541012162 catalytic residues [active] 716541012163 Uncharacterized conserved protein [Function unknown]; Region: COG3148 716541012164 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 716541012165 CoA binding domain; Region: CoA_binding_2; pfam13380 716541012166 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 716541012167 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 716541012168 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 716541012169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541012170 Coenzyme A binding pocket [chemical binding]; other site 716541012171 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 716541012172 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 716541012173 domain interface [polypeptide binding]; other site 716541012174 putative active site [active] 716541012175 catalytic site [active] 716541012176 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 716541012177 domain interface [polypeptide binding]; other site 716541012178 putative active site [active] 716541012179 catalytic site [active] 716541012180 lipoprotein; Provisional; Region: PRK10759 716541012181 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 716541012182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541012183 putative substrate translocation pore; other site 716541012184 protein disaggregation chaperone; Provisional; Region: PRK10865 716541012185 Clp amino terminal domain; Region: Clp_N; pfam02861 716541012186 Clp amino terminal domain; Region: Clp_N; pfam02861 716541012187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541012188 Walker A motif; other site 716541012189 ATP binding site [chemical binding]; other site 716541012190 Walker B motif; other site 716541012191 arginine finger; other site 716541012192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541012193 Walker A motif; other site 716541012194 ATP binding site [chemical binding]; other site 716541012195 Walker B motif; other site 716541012196 arginine finger; other site 716541012197 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 716541012198 hypothetical protein; Provisional; Region: PRK10723 716541012199 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 716541012200 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 716541012201 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 716541012202 active site 716541012203 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 716541012204 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 716541012205 30S subunit binding site; other site 716541012206 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 716541012207 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 716541012208 Prephenate dehydratase; Region: PDT; pfam00800 716541012209 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 716541012210 putative L-Phe binding site [chemical binding]; other site 716541012211 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 716541012212 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 716541012213 Chorismate mutase type II; Region: CM_2; cl00693 716541012214 prephenate dehydrogenase; Validated; Region: PRK08507 716541012215 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 716541012216 lipoprotein; Provisional; Region: PRK11443 716541012217 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 716541012218 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 716541012219 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541012220 metal binding site [ion binding]; metal-binding site 716541012221 active site 716541012222 I-site; other site 716541012223 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 716541012224 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 716541012225 ligand binding site [chemical binding]; other site 716541012226 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 716541012227 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 716541012228 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 716541012229 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 716541012230 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 716541012231 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 716541012232 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 716541012233 RimM N-terminal domain; Region: RimM; pfam01782 716541012234 PRC-barrel domain; Region: PRC; pfam05239 716541012235 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 716541012236 signal recognition particle protein; Provisional; Region: PRK10867 716541012237 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 716541012238 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 716541012239 P loop; other site 716541012240 GTP binding site [chemical binding]; other site 716541012241 Signal peptide binding domain; Region: SRP_SPB; pfam02978 716541012242 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 716541012243 hypothetical protein; Provisional; Region: PRK11573 716541012244 Domain of unknown function DUF21; Region: DUF21; pfam01595 716541012245 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 716541012246 Transporter associated domain; Region: CorC_HlyC; smart01091 716541012247 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 716541012248 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 716541012249 dimer interface [polypeptide binding]; other site 716541012250 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 716541012251 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 716541012252 recombination and repair protein; Provisional; Region: PRK10869 716541012253 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 716541012254 Walker A/P-loop; other site 716541012255 ATP binding site [chemical binding]; other site 716541012256 Q-loop/lid; other site 716541012257 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 716541012258 ABC transporter signature motif; other site 716541012259 Walker B; other site 716541012260 D-loop; other site 716541012261 H-loop/switch region; other site 716541012262 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 716541012263 hypothetical protein; Validated; Region: PRK01777 716541012264 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 716541012265 putative coenzyme Q binding site [chemical binding]; other site 716541012266 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 716541012267 SmpB-tmRNA interface; other site 716541012268 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 716541012269 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 716541012270 acyl-activating enzyme (AAE) consensus motif; other site 716541012271 AMP binding site [chemical binding]; other site 716541012272 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 716541012273 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 716541012274 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 716541012275 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 716541012276 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 716541012277 EamA-like transporter family; Region: EamA; pfam00892 716541012278 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 716541012279 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541012280 non-specific DNA binding site [nucleotide binding]; other site 716541012281 salt bridge; other site 716541012282 sequence-specific DNA binding site [nucleotide binding]; other site 716541012283 Cupin domain; Region: Cupin_2; cl17218 716541012284 LysE type translocator; Region: LysE; cl00565 716541012285 Ubiquitin-like proteins; Region: UBQ; cl00155 716541012286 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 716541012287 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 716541012288 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 716541012289 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 716541012290 DNA binding site [nucleotide binding] 716541012291 active site 716541012292 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 716541012293 tetramer interface [polypeptide binding]; other site 716541012294 active site 716541012295 Mg2+/Mn2+ binding site [ion binding]; other site 716541012296 Protein of unknown function (DUF443); Region: DUF443; cl04467 716541012297 translation-associated GTPase; Reviewed; Region: PRK09602 716541012298 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 716541012299 substrate binding pocket [chemical binding]; other site 716541012300 active site 716541012301 iron coordination sites [ion binding]; other site 716541012302 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 716541012303 substrate binding site [chemical binding]; other site 716541012304 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 716541012305 substrate binding site [chemical binding]; other site 716541012306 ligand binding site [chemical binding]; other site 716541012307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541012308 putative substrate translocation pore; other site 716541012309 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716541012310 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 716541012311 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 716541012312 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541012313 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 716541012314 substrate binding site [chemical binding]; other site 716541012315 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 716541012316 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 716541012317 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541012318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541012319 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 716541012320 putative effector binding pocket; other site 716541012321 dimerization interface [polypeptide binding]; other site 716541012322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541012323 benzoate transport; Region: 2A0115; TIGR00895 716541012324 putative substrate translocation pore; other site 716541012325 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541012326 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541012327 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 716541012328 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541012329 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541012330 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541012331 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541012332 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541012333 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541012334 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541012335 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541012336 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 716541012337 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541012338 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541012339 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541012340 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541012341 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541012342 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541012343 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 716541012344 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 716541012345 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 716541012346 Outer membrane efflux protein; Region: OEP; pfam02321 716541012347 Outer membrane efflux protein; Region: OEP; pfam02321 716541012348 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 716541012349 putative active site [active] 716541012350 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 716541012351 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 716541012352 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541012353 Walker A/P-loop; other site 716541012354 ATP binding site [chemical binding]; other site 716541012355 Q-loop/lid; other site 716541012356 ABC transporter signature motif; other site 716541012357 Walker B; other site 716541012358 D-loop; other site 716541012359 H-loop/switch region; other site 716541012360 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 716541012361 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541012362 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 716541012363 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541012364 Protein of unknown function (DUF796); Region: DUF796; cl01226 716541012365 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 716541012366 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 716541012367 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541012368 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541012369 SnoaL-like domain; Region: SnoaL_2; pfam12680 716541012370 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 716541012371 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 716541012372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541012373 homodimer interface [polypeptide binding]; other site 716541012374 catalytic residue [active] 716541012375 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541012376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541012377 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 716541012378 putative effector binding pocket; other site 716541012379 putative dimerization interface [polypeptide binding]; other site 716541012380 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 716541012381 short chain dehydrogenase; Region: adh_short; pfam00106 716541012382 putative NAD(P) binding site [chemical binding]; other site 716541012383 homodimer interface [polypeptide binding]; other site 716541012384 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 716541012385 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 716541012386 PYR/PP interface [polypeptide binding]; other site 716541012387 dimer interface [polypeptide binding]; other site 716541012388 TPP binding site [chemical binding]; other site 716541012389 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 716541012390 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 716541012391 TPP-binding site [chemical binding]; other site 716541012392 dimer interface [polypeptide binding]; other site 716541012393 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 716541012394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716541012395 NAD(P) binding site [chemical binding]; other site 716541012396 active site 716541012397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541012398 D-galactonate transporter; Region: 2A0114; TIGR00893 716541012399 putative substrate translocation pore; other site 716541012400 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 716541012401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541012402 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 716541012403 dimerization interface [polypeptide binding]; other site 716541012404 substrate binding pocket [chemical binding]; other site 716541012405 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 716541012406 cytosine deaminase; Provisional; Region: PRK05985 716541012407 active site 716541012408 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 716541012409 putative substrate binding site [chemical binding]; other site 716541012410 nucleotide binding site [chemical binding]; other site 716541012411 nucleotide binding site [chemical binding]; other site 716541012412 homodimer interface [polypeptide binding]; other site 716541012413 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 716541012414 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 716541012415 CoA binding domain; Region: CoA_binding; pfam02629 716541012416 CoA-ligase; Region: Ligase_CoA; pfam00549 716541012417 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 716541012418 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 716541012419 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 716541012420 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 716541012421 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 716541012422 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541012423 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541012424 dimerization interface [polypeptide binding]; other site 716541012425 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 716541012426 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 716541012427 active site residue [active] 716541012428 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 716541012429 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 716541012430 Domain in histone-like proteins of HNS family; Region: HNS; cl19571 716541012431 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 716541012432 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 716541012433 hypothetical protein; Provisional; Region: PRK10556 716541012434 hypothetical protein; Provisional; Region: PRK10132 716541012435 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 716541012436 catalytic residues [active] 716541012437 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 716541012438 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 716541012439 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 716541012440 Class I ribonucleotide reductase; Region: RNR_I; cd01679 716541012441 active site 716541012442 dimer interface [polypeptide binding]; other site 716541012443 catalytic residues [active] 716541012444 effector binding site; other site 716541012445 R2 peptide binding site; other site 716541012446 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 716541012447 dimer interface [polypeptide binding]; other site 716541012448 putative radical transfer pathway; other site 716541012449 diiron center [ion binding]; other site 716541012450 tyrosyl radical; other site 716541012451 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 716541012452 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 716541012453 Walker A/P-loop; other site 716541012454 ATP binding site [chemical binding]; other site 716541012455 Q-loop/lid; other site 716541012456 ABC transporter signature motif; other site 716541012457 Walker B; other site 716541012458 D-loop; other site 716541012459 H-loop/switch region; other site 716541012460 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 716541012461 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 716541012462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541012463 dimer interface [polypeptide binding]; other site 716541012464 conserved gate region; other site 716541012465 putative PBP binding loops; other site 716541012466 ABC-ATPase subunit interface; other site 716541012467 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 716541012468 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 716541012469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541012470 putative substrate translocation pore; other site 716541012471 transcriptional repressor MprA; Provisional; Region: PRK10870 716541012472 Transcriptional regulators [Transcription]; Region: MarR; COG1846 716541012473 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 716541012474 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541012475 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541012476 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 716541012477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541012478 putative substrate translocation pore; other site 716541012479 2-isopropylmalate synthase; Validated; Region: PRK03739 716541012480 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 716541012481 active site 716541012482 catalytic residues [active] 716541012483 metal binding site [ion binding]; metal-binding site 716541012484 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 716541012485 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 716541012486 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 716541012487 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541012488 S-ribosylhomocysteinase; Provisional; Region: PRK02260 716541012489 glutamate--cysteine ligase; Provisional; Region: PRK02107 716541012490 Predicted membrane protein [Function unknown]; Region: COG1238 716541012491 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 716541012492 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 716541012493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541012494 motif II; other site 716541012495 carbon storage regulator; Provisional; Region: PRK01712 716541012496 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 716541012497 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 716541012498 motif 1; other site 716541012499 active site 716541012500 motif 2; other site 716541012501 motif 3; other site 716541012502 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 716541012503 DHHA1 domain; Region: DHHA1; pfam02272 716541012504 recombination regulator RecX; Reviewed; Region: recX; PRK00117 716541012505 recombinase A; Provisional; Region: recA; PRK09354 716541012506 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 716541012507 hexamer interface [polypeptide binding]; other site 716541012508 Walker A motif; other site 716541012509 ATP binding site [chemical binding]; other site 716541012510 Walker B motif; other site 716541012511 hypothetical protein; Validated; Region: PRK03661 716541012512 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 716541012513 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 716541012514 metal binding site [ion binding]; metal-binding site 716541012515 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 716541012516 ABC-ATPase subunit interface; other site 716541012517 dimer interface [polypeptide binding]; other site 716541012518 putative PBP binding regions; other site 716541012519 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 716541012520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541012521 Walker A/P-loop; other site 716541012522 ATP binding site [chemical binding]; other site 716541012523 Q-loop/lid; other site 716541012524 ABC transporter signature motif; other site 716541012525 Walker B; other site 716541012526 D-loop; other site 716541012527 H-loop/switch region; other site 716541012528 murein hydrolase B; Provisional; Region: PRK10760 716541012529 lytic murein transglycosylase B; Region: MltB; TIGR02282 716541012530 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716541012531 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716541012532 catalytic residue [active] 716541012533 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 716541012534 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 716541012535 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 716541012536 Nucleoside recognition; Region: Gate; pfam07670 716541012537 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 716541012538 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 716541012539 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 716541012540 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 716541012541 putative NAD(P) binding site [chemical binding]; other site 716541012542 active site 716541012543 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 716541012544 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 716541012545 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 716541012546 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 716541012547 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 716541012548 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 716541012549 putative active site [active] 716541012550 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 716541012551 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 716541012552 GAF domain; Region: GAF; pfam01590 716541012553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541012554 Walker A motif; other site 716541012555 ATP binding site [chemical binding]; other site 716541012556 Walker B motif; other site 716541012557 arginine finger; other site 716541012558 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 716541012559 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 716541012560 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 716541012561 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 716541012562 iron binding site [ion binding]; other site 716541012563 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 716541012564 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541012565 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716541012566 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 716541012567 [NiFe] hydrogenase maturation protein HypF; Region: hypF; TIGR00143 716541012568 HypF finger; Region: zf-HYPF; pfam07503 716541012569 HypF finger; Region: zf-HYPF; pfam07503 716541012570 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 716541012571 Acylphosphatase; Region: Acylphosphatase; pfam00708 716541012572 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 716541012573 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 716541012574 Transcriptional regulators [Transcription]; Region: PurR; COG1609 716541012575 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541012576 DNA binding site [nucleotide binding] 716541012577 domain linker motif; other site 716541012578 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 716541012579 dimerization interface (closed form) [polypeptide binding]; other site 716541012580 ligand binding site [chemical binding]; other site 716541012581 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 716541012582 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 716541012583 active site turn [active] 716541012584 phosphorylation site [posttranslational modification] 716541012585 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 716541012586 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 716541012587 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 716541012588 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 716541012589 nickel binding site [ion binding]; other site 716541012590 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 716541012591 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 716541012592 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 716541012593 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 716541012594 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 716541012595 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 716541012596 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 716541012597 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 716541012598 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 716541012599 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 716541012600 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 716541012601 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 716541012602 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 716541012603 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 716541012604 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 716541012605 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 716541012606 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 716541012607 hydrogenase assembly chaperone; Provisional; Region: PRK10409 716541012608 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 716541012609 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 716541012610 dimerization interface [polypeptide binding]; other site 716541012611 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 716541012612 ATP binding site [chemical binding]; other site 716541012613 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 716541012614 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 716541012615 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 716541012616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541012617 Walker A motif; other site 716541012618 ATP binding site [chemical binding]; other site 716541012619 Walker B motif; other site 716541012620 arginine finger; other site 716541012621 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 716541012622 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 716541012623 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 716541012624 intersubunit interface [polypeptide binding]; other site 716541012625 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716541012626 ABC-ATPase subunit interface; other site 716541012627 dimer interface [polypeptide binding]; other site 716541012628 putative PBP binding regions; other site 716541012629 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 716541012630 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 716541012631 Walker A/P-loop; other site 716541012632 ATP binding site [chemical binding]; other site 716541012633 Q-loop/lid; other site 716541012634 ABC transporter signature motif; other site 716541012635 Walker B; other site 716541012636 D-loop; other site 716541012637 H-loop/switch region; other site 716541012638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541012639 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716541012640 putative substrate translocation pore; other site 716541012641 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 716541012642 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 716541012643 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 716541012644 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 716541012645 MutS domain I; Region: MutS_I; pfam01624 716541012646 MutS domain II; Region: MutS_II; pfam05188 716541012647 MutS domain III; Region: MutS_III; pfam05192 716541012648 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 716541012649 Walker A/P-loop; other site 716541012650 ATP binding site [chemical binding]; other site 716541012651 Q-loop/lid; other site 716541012652 ABC transporter signature motif; other site 716541012653 Walker B; other site 716541012654 D-loop; other site 716541012655 H-loop/switch region; other site 716541012656 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 716541012657 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 716541012658 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 716541012659 Transcriptional regulators [Transcription]; Region: MarR; COG1846 716541012660 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 716541012661 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541012662 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541012663 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 716541012664 putative effector binding pocket; other site 716541012665 dimerization interface [polypeptide binding]; other site 716541012666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541012667 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716541012668 putative substrate translocation pore; other site 716541012669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 716541012670 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 716541012671 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 716541012672 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 716541012673 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 716541012674 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 716541012675 DNA binding residues [nucleotide binding] 716541012676 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 716541012677 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 716541012678 Peptidase family M23; Region: Peptidase_M23; pfam01551 716541012679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541012680 S-adenosylmethionine binding site [chemical binding]; other site 716541012681 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 716541012682 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 716541012683 Permutation of conserved domain; other site 716541012684 active site 716541012685 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 716541012686 homotrimer interaction site [polypeptide binding]; other site 716541012687 zinc binding site [ion binding]; other site 716541012688 CDP-binding sites; other site 716541012689 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 716541012690 substrate binding site; other site 716541012691 dimer interface; other site 716541012692 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 716541012693 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 716541012694 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 716541012695 ligand-binding site [chemical binding]; other site 716541012696 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 716541012697 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 716541012698 CysD dimerization site [polypeptide binding]; other site 716541012699 G1 box; other site 716541012700 putative GEF interaction site [polypeptide binding]; other site 716541012701 GTP/Mg2+ binding site [chemical binding]; other site 716541012702 Switch I region; other site 716541012703 G2 box; other site 716541012704 G3 box; other site 716541012705 Switch II region; other site 716541012706 G4 box; other site 716541012707 G5 box; other site 716541012708 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 716541012709 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 716541012710 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 716541012711 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 716541012712 Active Sites [active] 716541012713 siroheme synthase; Provisional; Region: cysG; PRK10637 716541012714 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 716541012715 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 716541012716 Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414 716541012717 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 716541012718 active site 716541012719 SAM binding site [chemical binding]; other site 716541012720 homodimer interface [polypeptide binding]; other site 716541012721 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 716541012722 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 716541012723 metal binding site [ion binding]; metal-binding site 716541012724 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 716541012725 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 716541012726 Active Sites [active] 716541012727 sulfite reductase subunit beta; Provisional; Region: PRK13504 716541012728 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 716541012729 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 716541012730 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 716541012731 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 716541012732 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 716541012733 Flavodoxin; Region: Flavodoxin_1; pfam00258 716541012734 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 716541012735 FAD binding pocket [chemical binding]; other site 716541012736 FAD binding motif [chemical binding]; other site 716541012737 catalytic residues [active] 716541012738 NAD binding pocket [chemical binding]; other site 716541012739 phosphate binding motif [ion binding]; other site 716541012740 beta-alpha-beta structure motif; other site 716541012741 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 716541012742 active site 716541012743 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 716541012744 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 716541012745 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 716541012746 putative active site cavity [active] 716541012747 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 716541012748 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 716541012749 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 716541012750 active site turn [active] 716541012751 phosphorylation site [posttranslational modification] 716541012752 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 716541012753 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 716541012754 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 716541012755 putative active site [active] 716541012756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716541012757 Male sterility protein; Region: NAD_binding_4; pfam07993 716541012758 NAD(P) binding site [chemical binding]; other site 716541012759 active site 716541012760 enolase; Provisional; Region: eno; PRK00077 716541012761 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 716541012762 dimer interface [polypeptide binding]; other site 716541012763 metal binding site [ion binding]; metal-binding site 716541012764 substrate binding pocket [chemical binding]; other site 716541012765 CTP synthetase; Validated; Region: pyrG; PRK05380 716541012766 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 716541012767 Catalytic site [active] 716541012768 active site 716541012769 UTP binding site [chemical binding]; other site 716541012770 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 716541012771 active site 716541012772 putative oxyanion hole; other site 716541012773 catalytic triad [active] 716541012774 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 716541012775 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 716541012776 homodimer interface [polypeptide binding]; other site 716541012777 metal binding site [ion binding]; metal-binding site 716541012778 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 716541012779 homodimer interface [polypeptide binding]; other site 716541012780 active site 716541012781 putative chemical substrate binding site [chemical binding]; other site 716541012782 metal binding site [ion binding]; metal-binding site 716541012783 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 716541012784 HD domain; Region: HD_4; pfam13328 716541012785 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 716541012786 synthetase active site [active] 716541012787 NTP binding site [chemical binding]; other site 716541012788 metal binding site [ion binding]; metal-binding site 716541012789 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 716541012790 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 716541012791 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 716541012792 TRAM domain; Region: TRAM; pfam01938 716541012793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541012794 S-adenosylmethionine binding site [chemical binding]; other site 716541012795 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 716541012796 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 716541012797 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541012798 dimerization interface [polypeptide binding]; other site 716541012799 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541012800 dimer interface [polypeptide binding]; other site 716541012801 phosphorylation site [posttranslational modification] 716541012802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541012803 ATP binding site [chemical binding]; other site 716541012804 Mg2+ binding site [ion binding]; other site 716541012805 G-X-G motif; other site 716541012806 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 716541012807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541012808 active site 716541012809 phosphorylation site [posttranslational modification] 716541012810 intermolecular recognition site; other site 716541012811 dimerization interface [polypeptide binding]; other site 716541012812 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 716541012813 putative binding surface; other site 716541012814 active site 716541012815 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 716541012816 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 716541012817 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 716541012818 active site 716541012819 tetramer interface [polypeptide binding]; other site 716541012820 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 716541012821 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 716541012822 active site 716541012823 tetramer interface [polypeptide binding]; other site 716541012824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541012825 D-galactonate transporter; Region: 2A0114; TIGR00893 716541012826 putative substrate translocation pore; other site 716541012827 flavodoxin; Provisional; Region: PRK08105 716541012828 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 716541012829 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 716541012830 probable active site [active] 716541012831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 716541012832 SecY interacting protein Syd; Provisional; Region: PRK04968 716541012833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 716541012834 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 716541012835 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 716541012836 Domain of unknown function (DUF4478); Region: DUF4478; pfam14793 716541012837 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 716541012838 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 716541012839 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 716541012840 serine transporter; Region: stp; TIGR00814 716541012841 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 716541012842 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 716541012843 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 716541012844 flap endonuclease-like protein; Provisional; Region: PRK09482 716541012845 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 716541012846 active site 716541012847 metal binding site 1 [ion binding]; metal-binding site 716541012848 putative 5' ssDNA interaction site; other site 716541012849 metal binding site 3; metal-binding site 716541012850 metal binding site 2 [ion binding]; metal-binding site 716541012851 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 716541012852 putative DNA binding site [nucleotide binding]; other site 716541012853 putative metal binding site [ion binding]; other site 716541012854 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 716541012855 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 716541012856 FtsJ-like methyltransferase; Region: FtsJ; cl17430 716541012857 hypothetical protein; Provisional; Region: PRK10873 716541012858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541012859 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 716541012860 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 716541012861 dimerization interface [polypeptide binding]; other site 716541012862 substrate binding pocket [chemical binding]; other site 716541012863 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 716541012864 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 716541012865 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 716541012866 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 716541012867 catalytic residue [active] 716541012868 Fe-S metabolizm associated domain; Region: SufE; cl00951 716541012869 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 716541012870 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 716541012871 putative ATP binding site [chemical binding]; other site 716541012872 putative substrate interface [chemical binding]; other site 716541012873 murein transglycosylase A; Provisional; Region: mltA; PRK11162 716541012874 MltA specific insert domain; Region: MltA; smart00925 716541012875 3D domain; Region: 3D; pfam06725 716541012876 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 716541012877 AMIN domain; Region: AMIN; pfam11741 716541012878 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 716541012879 active site 716541012880 metal binding site [ion binding]; metal-binding site 716541012881 N-acetylglutamate synthase; Validated; Region: PRK05279 716541012882 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 716541012883 putative feedback inhibition sensing region; other site 716541012884 putative nucleotide binding site [chemical binding]; other site 716541012885 putative substrate binding site [chemical binding]; other site 716541012886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541012887 Coenzyme A binding pocket [chemical binding]; other site 716541012888 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 716541012889 AAA domain; Region: AAA_30; pfam13604 716541012890 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 716541012891 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 716541012892 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 716541012893 protease3; Provisional; Region: PRK15101 716541012894 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 716541012895 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 716541012896 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 716541012897 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 716541012898 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 716541012899 hypothetical protein; Provisional; Region: PRK10332 716541012900 hypothetical protein; Provisional; Region: PRK11521 716541012901 hypothetical protein; Provisional; Region: PRK10557 716541012902 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 716541012903 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 716541012904 dimerization interface [polypeptide binding]; other site 716541012905 active site 716541012906 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 716541012907 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 716541012908 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 716541012909 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 716541012910 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 716541012911 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 716541012912 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 716541012913 putative active site [active] 716541012914 Ap4A binding site [chemical binding]; other site 716541012915 nudix motif; other site 716541012916 putative metal binding site [ion binding]; other site 716541012917 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 716541012918 putative DNA-binding cleft [nucleotide binding]; other site 716541012919 putative DNA clevage site; other site 716541012920 molecular lever; other site 716541012921 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 716541012922 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 716541012923 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 716541012924 active site 716541012925 catalytic tetrad [active] 716541012926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541012927 putative substrate translocation pore; other site 716541012928 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 716541012929 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 716541012930 putative acyl-acceptor binding pocket; other site 716541012931 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 716541012932 acyl-activating enzyme (AAE) consensus motif; other site 716541012933 putative AMP binding site [chemical binding]; other site 716541012934 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 716541012935 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541012936 DNA binding site [nucleotide binding] 716541012937 domain linker motif; other site 716541012938 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 716541012939 dimerization interface (closed form) [polypeptide binding]; other site 716541012940 ligand binding site [chemical binding]; other site 716541012941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541012942 Coenzyme A binding pocket [chemical binding]; other site 716541012943 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 716541012944 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541012945 DNA-binding site [nucleotide binding]; DNA binding site 716541012946 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 716541012947 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 716541012948 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 716541012949 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 716541012950 Transcriptional regulators [Transcription]; Region: PurR; COG1609 716541012951 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541012952 DNA binding site [nucleotide binding] 716541012953 domain linker motif; other site 716541012954 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 716541012955 dimerization interface (closed form) [polypeptide binding]; other site 716541012956 ligand binding site [chemical binding]; other site 716541012957 diaminopimelate decarboxylase; Provisional; Region: PRK11165 716541012958 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 716541012959 active site 716541012960 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 716541012961 substrate binding site [chemical binding]; other site 716541012962 catalytic residues [active] 716541012963 dimer interface [polypeptide binding]; other site 716541012964 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 716541012965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541012966 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541012967 dimerization interface [polypeptide binding]; other site 716541012968 putative racemase; Provisional; Region: PRK10200 716541012969 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 716541012970 LPS O-antigen length regulator; Provisional; Region: PRK10381 716541012971 Chain length determinant protein; Region: Wzz; pfam02706 716541012972 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 716541012973 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 716541012974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541012975 dimer interface [polypeptide binding]; other site 716541012976 conserved gate region; other site 716541012977 putative PBP binding loops; other site 716541012978 ABC-ATPase subunit interface; other site 716541012979 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 716541012980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541012981 dimer interface [polypeptide binding]; other site 716541012982 conserved gate region; other site 716541012983 putative PBP binding loops; other site 716541012984 ABC-ATPase subunit interface; other site 716541012985 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 716541012986 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 716541012987 Walker A/P-loop; other site 716541012988 ATP binding site [chemical binding]; other site 716541012989 Q-loop/lid; other site 716541012990 ABC transporter signature motif; other site 716541012991 Walker B; other site 716541012992 D-loop; other site 716541012993 H-loop/switch region; other site 716541012994 TOBE domain; Region: TOBE; pfam03459 716541012995 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 716541012996 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 716541012997 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 716541012998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541012999 putative substrate translocation pore; other site 716541013000 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 716541013001 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 716541013002 NADP binding site [chemical binding]; other site 716541013003 homodimer interface [polypeptide binding]; other site 716541013004 active site 716541013005 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 716541013006 Oligogalacturonate lyase; Region: Pectate_lyase22; pfam14583 716541013007 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 716541013008 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 716541013009 putative acyltransferase; Provisional; Region: PRK05790 716541013010 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 716541013011 dimer interface [polypeptide binding]; other site 716541013012 active site 716541013013 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541013014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541013015 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 716541013016 dimerization interface [polypeptide binding]; other site 716541013017 Predicted membrane protein [Function unknown]; Region: COG4125 716541013018 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 716541013019 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 716541013020 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 716541013021 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 716541013022 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 716541013023 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716541013024 putative DNA binding site [nucleotide binding]; other site 716541013025 putative Zn2+ binding site [ion binding]; other site 716541013026 AsnC family; Region: AsnC_trans_reg; pfam01037 716541013027 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 716541013028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541013029 Coenzyme A binding pocket [chemical binding]; other site 716541013030 Uncharacterized conserved protein [Function unknown]; Region: COG3592 716541013031 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 716541013032 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 716541013033 PA-IL-like protein; Region: PA-IL; pfam07828 716541013034 S-type Pyocin; Region: Pyocin_S; pfam06958 716541013035 PAAR motif; Region: PAAR_motif; pfam05488 716541013036 S-type Pyocin; Region: Pyocin_S; pfam06958 716541013037 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 716541013038 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 716541013039 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 716541013040 active site 716541013041 DNA binding site [nucleotide binding] 716541013042 Int/Topo IB signature motif; other site 716541013043 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 716541013044 MAEBL; Provisional; Region: PTZ00121 716541013045 Transposase; Region: HTH_Tnp_1; cl17663 716541013046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541013047 HTH-like domain; Region: HTH_21; pfam13276 716541013048 Integrase core domain; Region: rve; pfam00665 716541013049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541013050 Transposase; Region: HTH_Tnp_1; pfam01527 716541013051 putative transposase OrfB; Reviewed; Region: PHA02517 716541013052 HTH-like domain; Region: HTH_21; pfam13276 716541013053 Integrase core domain; Region: rve; pfam00665 716541013054 Integrase core domain; Region: rve_2; pfam13333 716541013055 DEAD-like helicases superfamily; Region: DEXDc; smart00487 716541013056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716541013057 ATP binding site [chemical binding]; other site 716541013058 putative Mg++ binding site [ion binding]; other site 716541013059 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 716541013060 putative transposase OrfB; Reviewed; Region: PHA02517 716541013061 HTH-like domain; Region: HTH_21; pfam13276 716541013062 Integrase core domain; Region: rve; pfam00665 716541013063 Integrase core domain; Region: rve_3; pfam13683 716541013064 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541013065 Transposase; Region: HTH_Tnp_1; cl17663 716541013066 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 716541013067 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 716541013068 Peptidase family M23; Region: Peptidase_M23; pfam01551 716541013069 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 716541013070 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 716541013071 active site 716541013072 metal binding site [ion binding]; metal-binding site 716541013073 nudix motif; other site 716541013074 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 716541013075 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 716541013076 dimer interface [polypeptide binding]; other site 716541013077 putative anticodon binding site; other site 716541013078 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 716541013079 motif 1; other site 716541013080 active site 716541013081 motif 2; other site 716541013082 motif 3; other site 716541013083 peptide chain release factor 2; Provisional; Region: PRK08787 716541013084 This domain is found in peptide chain release factors; Region: PCRF; smart00937 716541013085 RF-1 domain; Region: RF-1; pfam00472 716541013086 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 716541013087 DHH family; Region: DHH; pfam01368 716541013088 DHHA1 domain; Region: DHHA1; pfam02272 716541013089 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 716541013090 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 716541013091 dimerization domain [polypeptide binding]; other site 716541013092 dimer interface [polypeptide binding]; other site 716541013093 catalytic residues [active] 716541013094 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 716541013095 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 716541013096 active site 716541013097 Int/Topo IB signature motif; other site 716541013098 flavodoxin FldB; Provisional; Region: PRK12359 716541013099 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 716541013100 hypothetical protein; Provisional; Region: PRK10878 716541013101 putative global regulator; Reviewed; Region: PRK09559 716541013102 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 716541013103 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 716541013104 hemolysin; Provisional; Region: PRK15087 716541013105 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 716541013106 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 716541013107 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 716541013108 putative active site [active] 716541013109 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 716541013110 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 716541013111 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 716541013112 classical (c) SDRs; Region: SDR_c; cd05233 716541013113 NAD(P) binding site [chemical binding]; other site 716541013114 active site 716541013115 glycine dehydrogenase; Provisional; Region: PRK05367 716541013116 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 716541013117 tetramer interface [polypeptide binding]; other site 716541013118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541013119 catalytic residue [active] 716541013120 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 716541013121 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 716541013122 tetramer interface [polypeptide binding]; other site 716541013123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541013124 catalytic residue [active] 716541013125 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 716541013126 lipoyl attachment site [posttranslational modification]; other site 716541013127 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 716541013128 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 716541013129 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 716541013130 oxidoreductase; Provisional; Region: PRK08013 716541013131 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 716541013132 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 716541013133 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 716541013134 proline aminopeptidase P II; Provisional; Region: PRK10879 716541013135 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 716541013136 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 716541013137 active site 716541013138 hypothetical protein; Reviewed; Region: PRK01736 716541013139 Z-ring-associated protein; Provisional; Region: PRK10972 716541013140 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 716541013141 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 716541013142 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 716541013143 ligand binding site [chemical binding]; other site 716541013144 NAD binding site [chemical binding]; other site 716541013145 tetramer interface [polypeptide binding]; other site 716541013146 catalytic site [active] 716541013147 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 716541013148 L-serine binding site [chemical binding]; other site 716541013149 ACT domain interface; other site 716541013150 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 716541013151 tetramer (dimer of dimers) interface [polypeptide binding]; other site 716541013152 active site 716541013153 dimer interface [polypeptide binding]; other site 716541013154 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 716541013155 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541013156 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 716541013157 putative dimerization interface [polypeptide binding]; other site 716541013158 oxidative stress defense protein; Provisional; Region: PRK11087 716541013159 arginine exporter protein; Provisional; Region: PRK09304 716541013160 mechanosensitive channel MscS; Provisional; Region: PRK10334 716541013161 Mechanosensitive ion channel; Region: MS_channel; pfam00924 716541013162 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 716541013163 active site 716541013164 intersubunit interface [polypeptide binding]; other site 716541013165 zinc binding site [ion binding]; other site 716541013166 Na+ binding site [ion binding]; other site 716541013167 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 716541013168 substrate binding site [chemical binding]; other site 716541013169 hinge regions; other site 716541013170 ADP binding site [chemical binding]; other site 716541013171 catalytic site [active] 716541013172 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 716541013173 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 716541013174 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 716541013175 transketolase; Reviewed; Region: PRK12753 716541013176 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 716541013177 TPP-binding site [chemical binding]; other site 716541013178 dimer interface [polypeptide binding]; other site 716541013179 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 716541013180 PYR/PP interface [polypeptide binding]; other site 716541013181 dimer interface [polypeptide binding]; other site 716541013182 TPP binding site [chemical binding]; other site 716541013183 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 716541013184 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 716541013185 outer membrane porin, OprD family; Region: OprD; pfam03573 716541013186 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541013187 hypothetical protein; Provisional; Region: PRK07064 716541013188 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 716541013189 PYR/PP interface [polypeptide binding]; other site 716541013190 dimer interface [polypeptide binding]; other site 716541013191 TPP binding site [chemical binding]; other site 716541013192 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 716541013193 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 716541013194 TPP-binding site [chemical binding]; other site 716541013195 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 716541013196 NAD(P) binding site [chemical binding]; other site 716541013197 catalytic residues [active] 716541013198 L-aspartate dehydrogenase; Provisional; Region: PRK13303 716541013199 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 716541013200 Domain of unknown function DUF108; Region: DUF108; pfam01958 716541013201 short chain dehydrogenase; Provisional; Region: PRK07062 716541013202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716541013203 NAD(P) binding site [chemical binding]; other site 716541013204 active site 716541013205 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 716541013206 Putative lysophospholipase; Region: Hydrolase_4; cl19140 716541013207 Cupin domain; Region: Cupin_2; pfam07883 716541013208 D-galactonate transporter; Region: 2A0114; TIGR00893 716541013209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541013210 putative substrate translocation pore; other site 716541013211 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 716541013212 Squalene epoxidase; Region: SE; cl17314 716541013213 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716541013214 Reductase C-terminal; Region: Reductase_C; pfam14759 716541013215 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 716541013216 active site 716541013217 metal binding site [ion binding]; metal-binding site 716541013218 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 716541013219 active site 716541013220 metal binding site [ion binding]; metal-binding site 716541013221 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 716541013222 Transcriptional regulator [Transcription]; Region: IclR; COG1414 716541013223 Bacterial transcriptional regulator; Region: IclR; pfam01614 716541013224 short chain dehydrogenase; Provisional; Region: PRK12939 716541013225 classical (c) SDRs; Region: SDR_c; cd05233 716541013226 NAD(P) binding site [chemical binding]; other site 716541013227 active site 716541013228 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 716541013229 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 716541013230 [2Fe-2S] cluster binding site [ion binding]; other site 716541013231 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 716541013232 hydrophobic ligand binding site; other site 716541013233 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 716541013234 [2Fe-2S] cluster binding site [ion binding]; other site 716541013235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541013236 Major Facilitator Superfamily; Region: MFS_1; pfam07690 716541013237 putative substrate translocation pore; other site 716541013238 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 716541013239 oligomer interface [polypeptide binding]; other site 716541013240 putative active site [active] 716541013241 Mn binding site [ion binding]; other site 716541013242 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 716541013243 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 716541013244 dimer interface [polypeptide binding]; other site 716541013245 active site 716541013246 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 716541013247 catalytic residues [active] 716541013248 substrate binding site [chemical binding]; other site 716541013249 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 716541013250 S-adenosylmethionine synthetase; Validated; Region: PRK05250 716541013251 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 716541013252 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 716541013253 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 716541013254 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 716541013255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541013256 putative substrate translocation pore; other site 716541013257 hypothetical protein; Provisional; Region: PRK04860 716541013258 DNA-specific endonuclease I; Provisional; Region: PRK15137 716541013259 RNA methyltransferase, RsmE family; Region: TIGR00046 716541013260 glutathione synthetase; Provisional; Region: PRK05246 716541013261 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 716541013262 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 716541013263 hypothetical protein; Validated; Region: PRK00228 716541013264 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 716541013265 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 716541013266 Walker A motif; other site 716541013267 ATP binding site [chemical binding]; other site 716541013268 Walker B motif; other site 716541013269 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 716541013270 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 716541013271 catalytic residue [active] 716541013272 YGGT family; Region: YGGT; pfam02325 716541013273 Predicted integral membrane protein [Function unknown]; Region: COG0762 716541013274 hypothetical protein; Validated; Region: PRK05090 716541013275 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 716541013276 active site 716541013277 dimerization interface [polypeptide binding]; other site 716541013278 HemN family oxidoreductase; Provisional; Region: PRK05660 716541013279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716541013280 FeS/SAM binding site; other site 716541013281 HemN C-terminal domain; Region: HemN_C; pfam06969 716541013282 hypothetical protein; Provisional; Region: PRK10626 716541013283 hypothetical protein; Provisional; Region: PRK11702 716541013284 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 716541013285 adenine DNA glycosylase; Provisional; Region: PRK10880 716541013286 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 716541013287 minor groove reading motif; other site 716541013288 helix-hairpin-helix signature motif; other site 716541013289 substrate binding pocket [chemical binding]; other site 716541013290 active site 716541013291 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 716541013292 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 716541013293 DNA binding and oxoG recognition site [nucleotide binding] 716541013294 oxidative damage protection protein; Provisional; Region: PRK05408 716541013295 murein transglycosylase C; Provisional; Region: mltC; PRK11671 716541013296 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 716541013297 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 716541013298 N-acetyl-D-glucosamine binding site [chemical binding]; other site 716541013299 catalytic residue [active] 716541013300 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541013301 nucleoside transporter; Region: 2A0110; TIGR00889 716541013302 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 716541013303 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 716541013304 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 716541013305 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 716541013306 Coenzyme A transferase; Region: CoA_trans; cl17247 716541013307 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 716541013308 citrate lyase subunit gamma; Provisional; Region: PRK13253 716541013309 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 716541013310 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 716541013311 putative active site [active] 716541013312 (T/H)XGH motif; other site 716541013313 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 716541013314 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 716541013315 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 716541013316 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 716541013317 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 716541013318 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716541013319 putative active site [active] 716541013320 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 716541013321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541013322 ATP binding site [chemical binding]; other site 716541013323 Mg2+ binding site [ion binding]; other site 716541013324 G-X-G motif; other site 716541013325 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 716541013326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541013327 active site 716541013328 phosphorylation site [posttranslational modification] 716541013329 intermolecular recognition site; other site 716541013330 dimerization interface [polypeptide binding]; other site 716541013331 Transcriptional regulator; Region: CitT; pfam12431 716541013332 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 716541013333 ornithine decarboxylase; Provisional; Region: PRK13578 716541013334 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 716541013335 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 716541013336 homodimer interface [polypeptide binding]; other site 716541013337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541013338 catalytic residue [active] 716541013339 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 716541013340 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 716541013341 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541013342 Coenzyme A binding pocket [chemical binding]; other site 716541013343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 716541013344 Cytidylyltransferase family; Region: CTP_transf_1; cl17467 716541013345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 716541013346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541013347 dimer interface [polypeptide binding]; other site 716541013348 phosphorylation site [posttranslational modification] 716541013349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541013350 ATP binding site [chemical binding]; other site 716541013351 Mg2+ binding site [ion binding]; other site 716541013352 G-X-G motif; other site 716541013353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541013354 active site 716541013355 phosphorylation site [posttranslational modification] 716541013356 intermolecular recognition site; other site 716541013357 dimerization interface [polypeptide binding]; other site 716541013358 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 716541013359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541013360 active site 716541013361 phosphorylation site [posttranslational modification] 716541013362 intermolecular recognition site; other site 716541013363 dimerization interface [polypeptide binding]; other site 716541013364 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541013365 DNA binding residues [nucleotide binding] 716541013366 dimerization interface [polypeptide binding]; other site 716541013367 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 716541013368 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 716541013369 DNA binding residues [nucleotide binding] 716541013370 dimerization interface [polypeptide binding]; other site 716541013371 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 716541013372 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 716541013373 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 716541013374 Hypothetical glycosyl hydrolase family 13; Region: GHL13; pfam14883 716541013375 N-glycosyltransferase; Provisional; Region: PRK11204 716541013376 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 716541013377 DXD motif; other site 716541013378 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 716541013379 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 716541013380 hemin storage system protein; Provisional; Region: hmsS; PRK14584 716541013381 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 716541013382 CHAP domain; Region: CHAP; pfam05257 716541013383 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 716541013384 putative S-transferase; Provisional; Region: PRK11752 716541013385 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 716541013386 C-terminal domain interface [polypeptide binding]; other site 716541013387 GSH binding site (G-site) [chemical binding]; other site 716541013388 dimer interface [polypeptide binding]; other site 716541013389 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 716541013390 dimer interface [polypeptide binding]; other site 716541013391 N-terminal domain interface [polypeptide binding]; other site 716541013392 active site 716541013393 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 716541013394 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 716541013395 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541013396 dimerization interface [polypeptide binding]; other site 716541013397 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716541013398 dimer interface [polypeptide binding]; other site 716541013399 putative CheW interface [polypeptide binding]; other site 716541013400 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 716541013401 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 716541013402 active site 716541013403 catalytic tetrad [active] 716541013404 hypothetical protein; Provisional; Region: PRK05208 716541013405 biopolymer transport protein ExbD; Provisional; Region: PRK11267 716541013406 biopolymer transport protein ExbB; Provisional; Region: PRK10414 716541013407 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 716541013408 homodimer interface [polypeptide binding]; other site 716541013409 substrate-cofactor binding pocket; other site 716541013410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541013411 catalytic residue [active] 716541013412 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 716541013413 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 716541013414 dimer interface [polypeptide binding]; other site 716541013415 active site 716541013416 metal binding site [ion binding]; metal-binding site 716541013417 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 716541013418 active site 716541013419 catalytic tetrad [active] 716541013420 hypothetical protein; Provisional; Region: PRK01254 716541013421 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 716541013422 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 716541013423 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 716541013424 Cation transport protein; Region: TrkH; cl17365 716541013425 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 716541013426 FtsI repressor; Provisional; Region: PRK10883 716541013427 The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232 716541013428 Domain 2 interface [polypeptide binding]; other site 716541013429 Domain 3 interface [polypeptide binding]; other site 716541013430 trinuclear Cu binding site [ion binding]; other site 716541013431 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 716541013432 Domain 1 interface [polypeptide binding]; other site 716541013433 Domain 3 interface [polypeptide binding]; other site 716541013434 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 716541013435 Domain 2 interface [polypeptide binding]; other site 716541013436 Domain 1 interface [polypeptide binding]; other site 716541013437 Type 1 (T1) Cu binding site [ion binding]; other site 716541013438 trinuclear Cu binding site [ion binding]; other site 716541013439 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 716541013440 putative acyl-acceptor binding pocket; other site 716541013441 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 716541013442 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 716541013443 CAP-like domain; other site 716541013444 active site 716541013445 primary dimer interface [polypeptide binding]; other site 716541013446 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 716541013447 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 716541013448 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 716541013449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541013450 active site 716541013451 phosphorylation site [posttranslational modification] 716541013452 intermolecular recognition site; other site 716541013453 dimerization interface [polypeptide binding]; other site 716541013454 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541013455 DNA binding site [nucleotide binding] 716541013456 sensor protein QseC; Provisional; Region: PRK10337 716541013457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541013458 dimer interface [polypeptide binding]; other site 716541013459 phosphorylation site [posttranslational modification] 716541013460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541013461 ATP binding site [chemical binding]; other site 716541013462 Mg2+ binding site [ion binding]; other site 716541013463 G-X-G motif; other site 716541013464 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 716541013465 Uncharacterized conserved protein [Function unknown]; Region: COG1359 716541013466 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 716541013467 BON domain; Region: BON; pfam04972 716541013468 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 716541013469 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 716541013470 galactoside permease; Reviewed; Region: lacY; PRK09528 716541013471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541013472 putative substrate translocation pore; other site 716541013473 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 716541013474 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 716541013475 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 716541013476 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541013477 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541013478 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 716541013479 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 716541013480 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 716541013481 putative active site [active] 716541013482 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 716541013483 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 716541013484 siderophore binding site; other site 716541013485 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716541013486 ABC-ATPase subunit interface; other site 716541013487 dimer interface [polypeptide binding]; other site 716541013488 putative PBP binding regions; other site 716541013489 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 716541013490 ABC-ATPase subunit interface; other site 716541013491 dimer interface [polypeptide binding]; other site 716541013492 putative PBP binding regions; other site 716541013493 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 716541013494 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 716541013495 Walker A/P-loop; other site 716541013496 ATP binding site [chemical binding]; other site 716541013497 Q-loop/lid; other site 716541013498 ABC transporter signature motif; other site 716541013499 Walker B; other site 716541013500 D-loop; other site 716541013501 H-loop/switch region; other site 716541013502 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 716541013503 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 716541013504 N-terminal plug; other site 716541013505 ligand-binding site [chemical binding]; other site 716541013506 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 716541013507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541013508 ATP binding site [chemical binding]; other site 716541013509 Mg2+ binding site [ion binding]; other site 716541013510 G-X-G motif; other site 716541013511 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 716541013512 anchoring element; other site 716541013513 dimer interface [polypeptide binding]; other site 716541013514 ATP binding site [chemical binding]; other site 716541013515 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 716541013516 active site 716541013517 metal binding site [ion binding]; metal-binding site 716541013518 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 716541013519 esterase YqiA; Provisional; Region: PRK11071 716541013520 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 716541013521 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 716541013522 active site 716541013523 metal binding site [ion binding]; metal-binding site 716541013524 hexamer interface [polypeptide binding]; other site 716541013525 putative dehydrogenase; Provisional; Region: PRK11039 716541013526 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 716541013527 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 716541013528 dimer interface [polypeptide binding]; other site 716541013529 ADP-ribose binding site [chemical binding]; other site 716541013530 active site 716541013531 nudix motif; other site 716541013532 metal binding site [ion binding]; metal-binding site 716541013533 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 716541013534 Outer membrane efflux protein; Region: OEP; pfam02321 716541013535 Outer membrane efflux protein; Region: OEP; pfam02321 716541013536 hypothetical protein; Provisional; Region: PRK11653 716541013537 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 716541013538 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 716541013539 putative active site [active] 716541013540 metal binding site [ion binding]; metal-binding site 716541013541 zinc transporter ZupT; Provisional; Region: PRK04201 716541013542 putative fimbrial protein; Provisional; Region: PRK09733 716541013543 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 716541013544 PapC N-terminal domain; Region: PapC_N; pfam13954 716541013545 Outer membrane usher protein; Region: Usher; pfam00577 716541013546 PapC C-terminal domain; Region: PapC_C; pfam13953 716541013547 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 716541013548 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 716541013549 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 716541013550 Fimbrial protein; Region: Fimbrial; pfam00419 716541013551 Fimbrial protein; Region: Fimbrial; cl01416 716541013552 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 716541013553 PapC N-terminal domain; Region: PapC_N; pfam13954 716541013554 Outer membrane usher protein; Region: Usher; pfam00577 716541013555 PapC C-terminal domain; Region: PapC_C; pfam13953 716541013556 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 716541013557 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 716541013558 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 716541013559 Fimbrial protein; Region: Fimbrial; pfam00419 716541013560 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 716541013561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 716541013562 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 716541013563 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 716541013564 putative ribose interaction site [chemical binding]; other site 716541013565 putative ADP binding site [chemical binding]; other site 716541013566 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 716541013567 active site 716541013568 nucleotide binding site [chemical binding]; other site 716541013569 HIGH motif; other site 716541013570 KMSKS motif; other site 716541013571 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 716541013572 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 716541013573 metal binding triad; other site 716541013574 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 716541013575 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 716541013576 metal binding triad; other site 716541013577 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 716541013578 Uncharacterized conserved protein [Function unknown]; Region: COG3025 716541013579 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 716541013580 putative active site [active] 716541013581 putative metal binding residues [ion binding]; other site 716541013582 signature motif; other site 716541013583 putative triphosphate binding site [ion binding]; other site 716541013584 CHAD domain; Region: CHAD; cl10506 716541013585 SH3 domain-containing protein; Provisional; Region: PRK10884 716541013586 Bacterial SH3 domain; Region: SH3_3; pfam08239 716541013587 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 716541013588 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 716541013589 active site 716541013590 NTP binding site [chemical binding]; other site 716541013591 metal binding triad [ion binding]; metal-binding site 716541013592 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 716541013593 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 716541013594 Zn2+ binding site [ion binding]; other site 716541013595 Mg2+ binding site [ion binding]; other site 716541013596 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 716541013597 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 716541013598 homooctamer interface [polypeptide binding]; other site 716541013599 active site 716541013600 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 716541013601 UreD urease accessory protein; Region: UreD; cl00530 716541013602 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 716541013603 alpha-gamma subunit interface [polypeptide binding]; other site 716541013604 beta-gamma subunit interface [polypeptide binding]; other site 716541013605 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 716541013606 gamma-beta subunit interface [polypeptide binding]; other site 716541013607 alpha-beta subunit interface [polypeptide binding]; other site 716541013608 urease subunit alpha; Reviewed; Region: ureC; PRK13207 716541013609 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 716541013610 subunit interactions [polypeptide binding]; other site 716541013611 active site 716541013612 flap region; other site 716541013613 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 716541013614 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 716541013615 dimer interface [polypeptide binding]; other site 716541013616 catalytic residues [active] 716541013617 HupE / UreJ protein; Region: HupE_UreJ; cl01011 716541013618 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 716541013619 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 716541013620 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 716541013621 active site 716541013622 catalytic residues [active] 716541013623 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 716541013624 aromatic chitin/cellulose binding site residues [chemical binding]; other site 716541013625 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 716541013626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541013627 active site 716541013628 phosphorylation site [posttranslational modification] 716541013629 intermolecular recognition site; other site 716541013630 dimerization interface [polypeptide binding]; other site 716541013631 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541013632 DNA binding residues [nucleotide binding] 716541013633 dimerization interface [polypeptide binding]; other site 716541013634 UGMP family protein; Validated; Region: PRK09604 716541013635 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 716541013636 nucleotide binding site [chemical binding]; other site 716541013637 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 716541013638 DNA primase; Validated; Region: dnaG; PRK05667 716541013639 CHC2 zinc finger; Region: zf-CHC2; pfam01807 716541013640 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 716541013641 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 716541013642 active site 716541013643 metal binding site [ion binding]; metal-binding site 716541013644 interdomain interaction site; other site 716541013645 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 716541013646 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 716541013647 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 716541013648 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 716541013649 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 716541013650 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 716541013651 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 716541013652 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 716541013653 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 716541013654 DNA binding residues [nucleotide binding] 716541013655 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 716541013656 active site 716541013657 SUMO-1 interface [polypeptide binding]; other site 716541013658 tail protein; Provisional; Region: D; PHA02561 716541013659 Phage protein U [General function prediction only]; Region: COG3499 716541013660 Phage-related tail protein [Function unknown]; Region: COG5283 716541013661 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 716541013662 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 716541013663 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 716541013664 major tail tube protein; Provisional; Region: FII; PHA02600 716541013665 major tail sheath protein; Provisional; Region: FI; PHA02560 716541013666 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 716541013667 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 716541013668 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 716541013669 baseplate assembly protein; Provisional; Region: J; PHA02568 716541013670 baseplate wedge subunit; Provisional; Region: W; PHA02516 716541013671 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 716541013672 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 716541013673 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 716541013674 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 716541013675 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 716541013676 catalytic residues [active] 716541013677 Transmembrane protein 223; Region: TMEM223; pfam14640 716541013678 P2-like prophage tail protein X [General function prediction only]; Region: COG5004 716541013679 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 716541013680 Phage small terminase subunit; Region: Phage_term_smal; cl19614 716541013681 capsid protein; Provisional; Region: N; PHA02538 716541013682 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 716541013683 terminase ATPase subunit; Provisional; Region: P; PHA02535 716541013684 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 716541013685 portal vertex protein; Provisional; Region: Q; PHA02536 716541013686 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 716541013687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541013688 non-specific DNA binding site [nucleotide binding]; other site 716541013689 salt bridge; other site 716541013690 Helix-turn-helix of insertion element transposase; Region: HTH_Tnp_1_2; pfam13022 716541013691 sequence-specific DNA binding site [nucleotide binding]; other site 716541013692 TIGR04255 family protein; Region: sporadTIGR04255 716541013693 DinI-like family; Region: DinI; pfam06183 716541013694 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 716541013695 DNA adenine methylase (dam); Region: dam; TIGR00571 716541013696 DksA-like zinc finger domain containing protein; Region: PHA00080 716541013697 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 716541013698 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 716541013699 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 716541013700 integrase; Provisional; Region: int; PHA02601 716541013701 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 716541013702 dimer interface [polypeptide binding]; other site 716541013703 active site 716541013704 catalytic residues [active] 716541013705 Int/Topo IB signature motif; other site 716541013706 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 716541013707 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 716541013708 PapC N-terminal domain; Region: PapC_N; pfam13954 716541013709 Outer membrane usher protein; Region: Usher; pfam00577 716541013710 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 716541013711 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 716541013712 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541013713 substrate binding pocket [chemical binding]; other site 716541013714 membrane-bound complex binding site; other site 716541013715 hinge residues; other site 716541013716 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 716541013717 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541013718 substrate binding pocket [chemical binding]; other site 716541013719 membrane-bound complex binding site; other site 716541013720 hinge residues; other site 716541013721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541013722 dimer interface [polypeptide binding]; other site 716541013723 phosphorylation site [posttranslational modification] 716541013724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541013725 ATP binding site [chemical binding]; other site 716541013726 Mg2+ binding site [ion binding]; other site 716541013727 G-X-G motif; other site 716541013728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541013729 active site 716541013730 phosphorylation site [posttranslational modification] 716541013731 intermolecular recognition site; other site 716541013732 dimerization interface [polypeptide binding]; other site 716541013733 Hpt domain; Region: Hpt; pfam01627 716541013734 putative binding surface; other site 716541013735 active site 716541013736 transcriptional regulator FimZ; Provisional; Region: PRK09935 716541013737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541013738 active site 716541013739 phosphorylation site [posttranslational modification] 716541013740 intermolecular recognition site; other site 716541013741 dimerization interface [polypeptide binding]; other site 716541013742 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541013743 DNA binding residues [nucleotide binding] 716541013744 haemagglutination activity domain; Region: Haemagg_act; pfam05860 716541013745 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 716541013746 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 716541013747 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 716541013748 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 716541013749 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 716541013750 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 716541013751 Putative toxin 46; Region: Toxin_46; pfam15526 716541013752 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 716541013753 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 716541013754 Surface antigen; Region: Bac_surface_Ag; pfam01103 716541013755 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 716541013756 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 716541013757 HSP70 interaction site [polypeptide binding]; other site 716541013758 Protein of unknown function (DUF342); Region: DUF342; cl19219 716541013759 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 716541013760 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 716541013761 FAD binding pocket [chemical binding]; other site 716541013762 FAD binding motif [chemical binding]; other site 716541013763 phosphate binding motif [ion binding]; other site 716541013764 NAD binding pocket [chemical binding]; other site 716541013765 Predicted transcriptional regulators [Transcription]; Region: COG1695 716541013766 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 716541013767 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 716541013768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541013769 dimerization interface [polypeptide binding]; other site 716541013770 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716541013771 dimer interface [polypeptide binding]; other site 716541013772 putative CheW interface [polypeptide binding]; other site 716541013773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716541013774 PAS fold; Region: PAS_3; pfam08447 716541013775 putative active site [active] 716541013776 heme pocket [chemical binding]; other site 716541013777 HAMP domain; Region: HAMP; pfam00672 716541013778 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 716541013779 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 716541013780 dimer interface [polypeptide binding]; other site 716541013781 putative CheW interface [polypeptide binding]; other site 716541013782 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 716541013783 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 716541013784 inhibitor-cofactor binding pocket; inhibition site 716541013785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541013786 catalytic residue [active] 716541013787 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 716541013788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541013789 non-specific DNA binding site [nucleotide binding]; other site 716541013790 salt bridge; other site 716541013791 sequence-specific DNA binding site [nucleotide binding]; other site 716541013792 Domain of unknown function (DU1801); Region: DUF1801; cl17490 716541013793 Cupin domain; Region: Cupin_2; pfam07883 716541013794 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 716541013795 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 716541013796 inhibitor site; inhibition site 716541013797 active site 716541013798 dimer interface [polypeptide binding]; other site 716541013799 catalytic residue [active] 716541013800 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 716541013801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541013802 active site 716541013803 phosphorylation site [posttranslational modification] 716541013804 intermolecular recognition site; other site 716541013805 dimerization interface [polypeptide binding]; other site 716541013806 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541013807 DNA binding site [nucleotide binding] 716541013808 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 716541013809 arginine deiminase; Provisional; Region: PRK01388 716541013810 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 716541013811 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 716541013812 Short C-terminal domain; Region: SHOCT; pfam09851 716541013813 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 716541013814 YfaZ precursor; Region: YfaZ; pfam07437 716541013815 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541013816 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541013817 potential frameshift: common BLAST hit: gi|295697852|ref|YP_003602509.1| putative transposase 716541013818 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541013819 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541013820 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541013821 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 716541013822 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 716541013823 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 716541013824 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 716541013825 putative active site; other site 716541013826 catalytic residue [active] 716541013827 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 716541013828 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 716541013829 ligand binding site [chemical binding]; other site 716541013830 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 716541013831 TM-ABC transporter signature motif; other site 716541013832 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 716541013833 TM-ABC transporter signature motif; other site 716541013834 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 716541013835 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 716541013836 Walker A/P-loop; other site 716541013837 ATP binding site [chemical binding]; other site 716541013838 Q-loop/lid; other site 716541013839 ABC transporter signature motif; other site 716541013840 Walker B; other site 716541013841 D-loop; other site 716541013842 H-loop/switch region; other site 716541013843 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 716541013844 transcriptional regulator LsrR; Provisional; Region: PRK15418 716541013845 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 716541013846 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 716541013847 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 716541013848 putative N- and C-terminal domain interface [polypeptide binding]; other site 716541013849 putative active site [active] 716541013850 putative MgATP binding site [chemical binding]; other site 716541013851 catalytic site [active] 716541013852 metal binding site [ion binding]; metal-binding site 716541013853 putative carbohydrate binding site [chemical binding]; other site 716541013854 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 716541013855 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 716541013856 active site 716541013857 FMN binding site [chemical binding]; other site 716541013858 2,4-decadienoyl-CoA binding site; other site 716541013859 catalytic residue [active] 716541013860 4Fe-4S cluster binding site [ion binding]; other site 716541013861 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541013862 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 716541013863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541013864 S-adenosylmethionine binding site [chemical binding]; other site 716541013865 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 716541013866 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 716541013867 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 716541013868 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 716541013869 serine/threonine transporter SstT; Provisional; Region: PRK13628 716541013870 galactarate dehydratase; Region: galactar-dH20; TIGR03248 716541013871 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 716541013872 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 716541013873 glucuronate isomerase; Reviewed; Region: PRK02925 716541013874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541013875 D-galactonate transporter; Region: 2A0114; TIGR00893 716541013876 putative substrate translocation pore; other site 716541013877 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 716541013878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541013879 DNA-binding site [nucleotide binding]; DNA binding site 716541013880 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 716541013881 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 716541013882 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 716541013883 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 716541013884 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 716541013885 Predicted membrane protein [Function unknown]; Region: COG5393 716541013886 YqjK-like protein; Region: YqjK; pfam13997 716541013887 Predicted membrane protein [Function unknown]; Region: COG2259 716541013888 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 716541013889 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 716541013890 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 716541013891 putative dimer interface [polypeptide binding]; other site 716541013892 N-terminal domain interface [polypeptide binding]; other site 716541013893 putative substrate binding pocket (H-site) [chemical binding]; other site 716541013894 Predicted membrane protein [Function unknown]; Region: COG3152 716541013895 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541013896 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 716541013897 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541013898 dimerization interface [polypeptide binding]; other site 716541013899 Pirin-related protein [General function prediction only]; Region: COG1741 716541013900 Pirin; Region: Pirin; pfam02678 716541013901 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 716541013902 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 716541013903 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 716541013904 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 716541013905 Pyruvate formate lyase 1; Region: PFL1; cd01678 716541013906 coenzyme A binding site [chemical binding]; other site 716541013907 active site 716541013908 catalytic residues [active] 716541013909 glycine loop; other site 716541013910 propionate/acetate kinase; Provisional; Region: PRK12379 716541013911 threonine/serine transporter TdcC; Provisional; Region: PRK13629 716541013912 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 716541013913 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 716541013914 tetramer interface [polypeptide binding]; other site 716541013915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541013916 catalytic residue [active] 716541013917 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 716541013918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541013919 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541013920 dimerization interface [polypeptide binding]; other site 716541013921 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 716541013922 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 716541013923 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 716541013924 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 716541013925 galactarate dehydratase; Region: galactar-dH20; TIGR03248 716541013926 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 716541013927 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 716541013928 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 716541013929 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 716541013930 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 716541013931 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 716541013932 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 716541013933 active site 716541013934 phosphorylation site [posttranslational modification] 716541013935 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 716541013936 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 716541013937 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 716541013938 active pocket/dimerization site; other site 716541013939 active site 716541013940 phosphorylation site [posttranslational modification] 716541013941 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 716541013942 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 716541013943 active site 716541013944 dimer interface [polypeptide binding]; other site 716541013945 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 716541013946 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 716541013947 dimer interface [polypeptide binding]; other site 716541013948 active site 716541013949 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 716541013950 putative active site [active] 716541013951 tagatose-bisphosphate aldolase; Reviewed; Region: kbaY; PRK12738 716541013952 active site 716541013953 intersubunit interface [polypeptide binding]; other site 716541013954 zinc binding site [ion binding]; other site 716541013955 Na+ binding site [ion binding]; other site 716541013956 Melibiase; Region: Melibiase; pfam02065 716541013957 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 716541013958 putative SAM binding site [chemical binding]; other site 716541013959 putative homodimer interface [polypeptide binding]; other site 716541013960 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 716541013961 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 716541013962 putative ligand binding site [chemical binding]; other site 716541013963 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 716541013964 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 716541013965 dimer interface [polypeptide binding]; other site 716541013966 active site 716541013967 outer membrane lipoprotein; Provisional; Region: PRK11023 716541013968 BON domain; Region: BON; pfam04972 716541013969 BON domain; Region: BON; pfam04972 716541013970 Predicted permease; Region: DUF318; pfam03773 716541013971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716541013972 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 716541013973 NAD(P) binding site [chemical binding]; other site 716541013974 active site 716541013975 intracellular protease, PfpI family; Region: PfpI; TIGR01382 716541013976 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 716541013977 proposed catalytic triad [active] 716541013978 conserved cys residue [active] 716541013979 hypothetical protein; Provisional; Region: PRK03467 716541013980 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 716541013981 GIY-YIG motif/motif A; other site 716541013982 putative active site [active] 716541013983 putative metal binding site [ion binding]; other site 716541013984 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 716541013985 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541013986 Coenzyme A binding pocket [chemical binding]; other site 716541013987 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 716541013988 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 716541013989 putative protease; Provisional; Region: PRK15447 716541013990 hypothetical protein; Provisional; Region: PRK10508 716541013991 tryptophan permease; Provisional; Region: PRK10483 716541013992 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 716541013993 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 716541013994 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 716541013995 ATP binding site [chemical binding]; other site 716541013996 Mg++ binding site [ion binding]; other site 716541013997 motif III; other site 716541013998 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716541013999 nucleotide binding region [chemical binding]; other site 716541014000 ATP-binding site [chemical binding]; other site 716541014001 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 716541014002 putative RNA binding site [nucleotide binding]; other site 716541014003 lipoprotein NlpI; Provisional; Region: PRK11189 716541014004 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 716541014005 binding surface 716541014006 TPR motif; other site 716541014007 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 716541014008 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 716541014009 RNase E interface [polypeptide binding]; other site 716541014010 trimer interface [polypeptide binding]; other site 716541014011 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 716541014012 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 716541014013 RNase E interface [polypeptide binding]; other site 716541014014 trimer interface [polypeptide binding]; other site 716541014015 active site 716541014016 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 716541014017 putative nucleic acid binding region [nucleotide binding]; other site 716541014018 G-X-X-G motif; other site 716541014019 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 716541014020 RNA binding site [nucleotide binding]; other site 716541014021 domain interface; other site 716541014022 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 716541014023 16S/18S rRNA binding site [nucleotide binding]; other site 716541014024 S13e-L30e interaction site [polypeptide binding]; other site 716541014025 25S rRNA binding site [nucleotide binding]; other site 716541014026 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 716541014027 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 716541014028 RNA binding site [nucleotide binding]; other site 716541014029 active site 716541014030 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 716541014031 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 716541014032 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 716541014033 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 716541014034 translation initiation factor IF-2; Validated; Region: infB; PRK05306 716541014035 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 716541014036 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 716541014037 G1 box; other site 716541014038 putative GEF interaction site [polypeptide binding]; other site 716541014039 GTP/Mg2+ binding site [chemical binding]; other site 716541014040 Switch I region; other site 716541014041 G2 box; other site 716541014042 G3 box; other site 716541014043 Switch II region; other site 716541014044 G4 box; other site 716541014045 G5 box; other site 716541014046 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 716541014047 Translation-initiation factor 2; Region: IF-2; pfam11987 716541014048 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 716541014049 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 716541014050 NusA N-terminal domain; Region: NusA_N; pfam08529 716541014051 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 716541014052 RNA binding site [nucleotide binding]; other site 716541014053 homodimer interface [polypeptide binding]; other site 716541014054 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 716541014055 G-X-X-G motif; other site 716541014056 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 716541014057 G-X-X-G motif; other site 716541014058 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 716541014059 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 716541014060 hypothetical protein; Provisional; Region: PRK14641 716541014061 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 716541014062 putative oligomer interface [polypeptide binding]; other site 716541014063 putative RNA binding site [nucleotide binding]; other site 716541014064 argininosuccinate synthase; Validated; Region: PRK05370 716541014065 Preprotein translocase SecG subunit; Region: SecG; pfam03840 716541014066 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 716541014067 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 716541014068 active site 716541014069 substrate binding site [chemical binding]; other site 716541014070 metal binding site [ion binding]; metal-binding site 716541014071 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 716541014072 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 716541014073 substrate binding pocket [chemical binding]; other site 716541014074 dimer interface [polypeptide binding]; other site 716541014075 inhibitor binding site; inhibition site 716541014076 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 716541014077 FtsH Extracellular; Region: FtsH_ext; pfam06480 716541014078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541014079 Walker A motif; other site 716541014080 ATP binding site [chemical binding]; other site 716541014081 Walker B motif; other site 716541014082 arginine finger; other site 716541014083 Peptidase family M41; Region: Peptidase_M41; pfam01434 716541014084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541014085 S-adenosylmethionine binding site [chemical binding]; other site 716541014086 RNA-binding protein YhbY; Provisional; Region: PRK10343 716541014087 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 716541014088 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 716541014089 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 716541014090 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 716541014091 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 716541014092 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 716541014093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541014094 active site 716541014095 phosphorylation site [posttranslational modification] 716541014096 intermolecular recognition site; other site 716541014097 dimerization interface [polypeptide binding]; other site 716541014098 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541014099 DNA binding site [nucleotide binding] 716541014100 sensor protein BasS/PmrB; Provisional; Region: PRK10755 716541014101 HAMP domain; Region: HAMP; pfam00672 716541014102 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541014103 dimer interface [polypeptide binding]; other site 716541014104 phosphorylation site [posttranslational modification] 716541014105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541014106 ATP binding site [chemical binding]; other site 716541014107 Mg2+ binding site [ion binding]; other site 716541014108 G-X-G motif; other site 716541014109 GTPase CgtA; Reviewed; Region: obgE; PRK12298 716541014110 GTP1/OBG; Region: GTP1_OBG; pfam01018 716541014111 Obg GTPase; Region: Obg; cd01898 716541014112 G1 box; other site 716541014113 GTP/Mg2+ binding site [chemical binding]; other site 716541014114 Switch I region; other site 716541014115 G2 box; other site 716541014116 G3 box; other site 716541014117 Switch II region; other site 716541014118 G4 box; other site 716541014119 G5 box; other site 716541014120 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 716541014121 EamA-like transporter family; Region: EamA; pfam00892 716541014122 EamA-like transporter family; Region: EamA; pfam00892 716541014123 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 716541014124 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 716541014125 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 716541014126 substrate binding pocket [chemical binding]; other site 716541014127 chain length determination region; other site 716541014128 substrate-Mg2+ binding site; other site 716541014129 catalytic residues [active] 716541014130 aspartate-rich region 1; other site 716541014131 active site lid residues [active] 716541014132 aspartate-rich region 2; other site 716541014133 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 716541014134 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 716541014135 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 716541014136 hinge; other site 716541014137 active site 716541014138 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 716541014139 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 716541014140 anti sigma factor interaction site; other site 716541014141 regulatory phosphorylation site [posttranslational modification]; other site 716541014142 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 716541014143 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 716541014144 mce related protein; Region: MCE; pfam02470 716541014145 conserved hypothetical integral membrane protein; Region: TIGR00056 716541014146 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 716541014147 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 716541014148 Walker A/P-loop; other site 716541014149 ATP binding site [chemical binding]; other site 716541014150 Q-loop/lid; other site 716541014151 ABC transporter signature motif; other site 716541014152 Walker B; other site 716541014153 D-loop; other site 716541014154 H-loop/switch region; other site 716541014155 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 716541014156 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 716541014157 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 716541014158 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 716541014159 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 716541014160 putative active site [active] 716541014161 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 716541014162 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 716541014163 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 716541014164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 716541014165 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 716541014166 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 716541014167 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 716541014168 Walker A/P-loop; other site 716541014169 ATP binding site [chemical binding]; other site 716541014170 Q-loop/lid; other site 716541014171 ABC transporter signature motif; other site 716541014172 Walker B; other site 716541014173 D-loop; other site 716541014174 H-loop/switch region; other site 716541014175 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 716541014176 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 716541014177 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 716541014178 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 716541014179 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 716541014180 30S subunit binding site; other site 716541014181 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 716541014182 active site 716541014183 phosphorylation site [posttranslational modification] 716541014184 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 716541014185 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 716541014186 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 716541014187 dimerization domain swap beta strand [polypeptide binding]; other site 716541014188 regulatory protein interface [polypeptide binding]; other site 716541014189 active site 716541014190 regulatory phosphorylation site [posttranslational modification]; other site 716541014191 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 716541014192 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 716541014193 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 716541014194 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 716541014195 conserved cys residue [active] 716541014196 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 716541014197 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716541014198 putative active site [active] 716541014199 heme pocket [chemical binding]; other site 716541014200 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541014201 dimer interface [polypeptide binding]; other site 716541014202 phosphorylation site [posttranslational modification] 716541014203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541014204 ATP binding site [chemical binding]; other site 716541014205 Mg2+ binding site [ion binding]; other site 716541014206 G-X-G motif; other site 716541014207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541014208 active site 716541014209 phosphorylation site [posttranslational modification] 716541014210 intermolecular recognition site; other site 716541014211 dimerization interface [polypeptide binding]; other site 716541014212 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 716541014213 putative binding surface; other site 716541014214 active site 716541014215 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 716541014216 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 716541014217 multifunctional aminopeptidase A; Provisional; Region: PRK00913 716541014218 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 716541014219 interface (dimer of trimers) [polypeptide binding]; other site 716541014220 Substrate-binding/catalytic site; other site 716541014221 Zn-binding sites [ion binding]; other site 716541014222 DNA polymerase III subunit chi; Validated; Region: PRK05728 716541014223 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 716541014224 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 716541014225 active site 716541014226 HIGH motif; other site 716541014227 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 716541014228 KMSKS motif; other site 716541014229 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 716541014230 tRNA binding surface [nucleotide binding]; other site 716541014231 anticodon binding site; other site 716541014232 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 716541014233 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 716541014234 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541014235 Coenzyme A binding pocket [chemical binding]; other site 716541014236 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 716541014237 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 716541014238 putative NAD(P) binding site [chemical binding]; other site 716541014239 putative substrate binding site [chemical binding]; other site 716541014240 catalytic Zn binding site [ion binding]; other site 716541014241 structural Zn binding site [ion binding]; other site 716541014242 dimer interface [polypeptide binding]; other site 716541014243 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 716541014244 Dak1 domain; Region: Dak1; cl10557 716541014245 DAK2 domain; Region: Dak2; pfam02734 716541014246 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 716541014247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541014248 Walker A motif; other site 716541014249 ATP binding site [chemical binding]; other site 716541014250 radical SAM protein, TIGR01212 family; Region: TIGR01212 716541014251 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716541014252 FeS/SAM binding site; other site 716541014253 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 716541014254 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 716541014255 active site 716541014256 dimer interface [polypeptide binding]; other site 716541014257 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 716541014258 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 716541014259 active site 716541014260 FMN binding site [chemical binding]; other site 716541014261 substrate binding site [chemical binding]; other site 716541014262 3Fe-4S cluster binding site [ion binding]; other site 716541014263 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 716541014264 domain interface; other site 716541014265 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 716541014266 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 716541014267 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541014268 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716541014269 hypothetical protein; Provisional; Region: PRK15301 716541014270 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 716541014271 PapC N-terminal domain; Region: PapC_N; pfam13954 716541014272 Outer membrane usher protein; Region: Usher; pfam00577 716541014273 PapC C-terminal domain; Region: PapC_C; pfam13953 716541014274 putative fimbrial chaperone protein; Provisional; Region: PRK09918 716541014275 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 716541014276 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 716541014277 hypothetical protein; Provisional; Region: PRK15302 716541014278 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 716541014279 stringent starvation protein A; Provisional; Region: sspA; PRK09481 716541014280 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 716541014281 C-terminal domain interface [polypeptide binding]; other site 716541014282 putative GSH binding site (G-site) [chemical binding]; other site 716541014283 dimer interface [polypeptide binding]; other site 716541014284 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 716541014285 dimer interface [polypeptide binding]; other site 716541014286 N-terminal domain interface [polypeptide binding]; other site 716541014287 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 716541014288 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 716541014289 23S rRNA interface [nucleotide binding]; other site 716541014290 L3 interface [polypeptide binding]; other site 716541014291 Predicted ATPase [General function prediction only]; Region: COG1485 716541014292 hypothetical protein; Provisional; Region: PRK11677 716541014293 serine endoprotease; Provisional; Region: PRK10139 716541014294 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 716541014295 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 716541014296 protein binding site [polypeptide binding]; other site 716541014297 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 716541014298 serine endoprotease; Provisional; Region: PRK10898 716541014299 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 716541014300 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 716541014301 protein binding site [polypeptide binding]; other site 716541014302 malate dehydrogenase; Provisional; Region: PRK05086 716541014303 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 716541014304 NAD binding site [chemical binding]; other site 716541014305 dimerization interface [polypeptide binding]; other site 716541014306 Substrate binding site [chemical binding]; other site 716541014307 arginine repressor; Provisional; Region: PRK05066 716541014308 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 716541014309 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 716541014310 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 716541014311 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 716541014312 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 716541014313 RNAase interaction site [polypeptide binding]; other site 716541014314 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 716541014315 tetramerization interface [polypeptide binding]; other site 716541014316 NAD(P) binding site [chemical binding]; other site 716541014317 catalytic residues [active] 716541014318 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 716541014319 Fusaric acid resistance protein family; Region: FUSC; pfam04632 716541014320 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 716541014321 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541014322 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541014323 efflux system membrane protein; Provisional; Region: PRK11594 716541014324 transcriptional regulator; Provisional; Region: PRK10632 716541014325 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541014326 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 716541014327 putative effector binding pocket; other site 716541014328 dimerization interface [polypeptide binding]; other site 716541014329 protease TldD; Provisional; Region: tldD; PRK10735 716541014330 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 716541014331 hypothetical protein; Provisional; Region: PRK10899 716541014332 Protein of unknown function; Region: DUF3971; pfam13116 716541014333 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 716541014334 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 716541014335 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 716541014336 homodimer interface [polypeptide binding]; other site 716541014337 oligonucleotide binding site [chemical binding]; other site 716541014338 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 716541014339 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 716541014340 active site 716541014341 dimer interface [polypeptide binding]; other site 716541014342 rod shape-determining protein MreD; Provisional; Region: PRK11060 716541014343 rod shape-determining protein MreC; Region: mreC; TIGR00219 716541014344 rod shape-determining protein MreB; Provisional; Region: PRK13927 716541014345 MreB and similar proteins; Region: MreB_like; cd10225 716541014346 nucleotide binding site [chemical binding]; other site 716541014347 Mg binding site [ion binding]; other site 716541014348 putative protofilament interaction site [polypeptide binding]; other site 716541014349 RodZ interaction site [polypeptide binding]; other site 716541014350 regulatory protein CsrD; Provisional; Region: PRK11059 716541014351 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541014352 metal binding site [ion binding]; metal-binding site 716541014353 active site 716541014354 I-site; other site 716541014355 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541014356 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 716541014357 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 716541014358 NADP binding site [chemical binding]; other site 716541014359 dimer interface [polypeptide binding]; other site 716541014360 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 716541014361 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 716541014362 Moco binding site; other site 716541014363 metal coordination site [ion binding]; other site 716541014364 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 716541014365 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 716541014366 trimer interface [polypeptide binding]; other site 716541014367 active site 716541014368 dimer interface [polypeptide binding]; other site 716541014369 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 716541014370 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 716541014371 carboxyltransferase (CT) interaction site; other site 716541014372 biotinylation site [posttranslational modification]; other site 716541014373 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 716541014374 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 716541014375 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 716541014376 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 716541014377 hypothetical protein; Provisional; Region: PRK10633 716541014378 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 716541014379 Na binding site [ion binding]; other site 716541014380 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 716541014381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541014382 S-adenosylmethionine binding site [chemical binding]; other site 716541014383 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 716541014384 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 716541014385 FMN binding site [chemical binding]; other site 716541014386 active site 716541014387 catalytic residues [active] 716541014388 substrate binding site [chemical binding]; other site 716541014389 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 716541014390 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 716541014391 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 716541014392 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 716541014393 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 716541014394 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 716541014395 metal binding site [ion binding]; metal-binding site 716541014396 active site 716541014397 I-site; other site 716541014398 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541014399 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 716541014400 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 716541014401 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541014402 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 716541014403 MMPL family; Region: MMPL; cl14618 716541014404 MMPL family; Region: MMPL; cl14618 716541014405 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 716541014406 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541014407 substrate binding pocket [chemical binding]; other site 716541014408 membrane-bound complex binding site; other site 716541014409 hinge residues; other site 716541014410 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 716541014411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 716541014412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541014413 dimer interface [polypeptide binding]; other site 716541014414 ABC-ATPase subunit interface; other site 716541014415 putative PBP binding loops; other site 716541014416 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 716541014417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541014418 dimer interface [polypeptide binding]; other site 716541014419 conserved gate region; other site 716541014420 putative PBP binding loops; other site 716541014421 ABC-ATPase subunit interface; other site 716541014422 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 716541014423 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 716541014424 Walker A/P-loop; other site 716541014425 ATP binding site [chemical binding]; other site 716541014426 Q-loop/lid; other site 716541014427 ABC transporter signature motif; other site 716541014428 Walker B; other site 716541014429 D-loop; other site 716541014430 H-loop/switch region; other site 716541014431 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 716541014432 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 716541014433 trimer interface [polypeptide binding]; other site 716541014434 putative metal binding site [ion binding]; other site 716541014435 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 716541014436 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 716541014437 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 716541014438 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 716541014439 shikimate binding site; other site 716541014440 NAD(P) binding site [chemical binding]; other site 716541014441 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 716541014442 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 716541014443 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 716541014444 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 716541014445 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 716541014446 hypothetical protein; Validated; Region: PRK03430 716541014447 hypothetical protein; Provisional; Region: PRK10736 716541014448 DNA protecting protein DprA; Region: dprA; TIGR00732 716541014449 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 716541014450 active site 716541014451 catalytic residues [active] 716541014452 metal binding site [ion binding]; metal-binding site 716541014453 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 716541014454 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 716541014455 putative active site [active] 716541014456 substrate binding site [chemical binding]; other site 716541014457 putative cosubstrate binding site; other site 716541014458 catalytic site [active] 716541014459 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 716541014460 substrate binding site [chemical binding]; other site 716541014461 16S rRNA methyltransferase B; Provisional; Region: PRK10901 716541014462 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 716541014463 putative RNA binding site [nucleotide binding]; other site 716541014464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541014465 S-adenosylmethionine binding site [chemical binding]; other site 716541014466 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 716541014467 TrkA-N domain; Region: TrkA_N; pfam02254 716541014468 TrkA-C domain; Region: TrkA_C; pfam02080 716541014469 TrkA-N domain; Region: TrkA_N; pfam02254 716541014470 TrkA-C domain; Region: TrkA_C; pfam02080 716541014471 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 716541014472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 716541014473 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 716541014474 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 716541014475 DNA binding residues [nucleotide binding] 716541014476 dimer interface [polypeptide binding]; other site 716541014477 metal binding site [ion binding]; metal-binding site 716541014478 hypothetical protein; Provisional; Region: PRK10203 716541014479 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 716541014480 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 716541014481 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 716541014482 alphaNTD homodimer interface [polypeptide binding]; other site 716541014483 alphaNTD - beta interaction site [polypeptide binding]; other site 716541014484 alphaNTD - beta' interaction site [polypeptide binding]; other site 716541014485 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 716541014486 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 716541014487 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 716541014488 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 716541014489 RNA binding surface [nucleotide binding]; other site 716541014490 30S ribosomal protein S11; Validated; Region: PRK05309 716541014491 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 716541014492 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 716541014493 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 716541014494 SecY translocase; Region: SecY; pfam00344 716541014495 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 716541014496 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 716541014497 23S rRNA binding site [nucleotide binding]; other site 716541014498 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 716541014499 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 716541014500 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 716541014501 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 716541014502 23S rRNA interface [nucleotide binding]; other site 716541014503 5S rRNA interface [nucleotide binding]; other site 716541014504 L27 interface [polypeptide binding]; other site 716541014505 L5 interface [polypeptide binding]; other site 716541014506 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 716541014507 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 716541014508 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 716541014509 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 716541014510 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 716541014511 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 716541014512 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 716541014513 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 716541014514 RNA binding site [nucleotide binding]; other site 716541014515 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 716541014516 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 716541014517 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 716541014518 23S rRNA interface [nucleotide binding]; other site 716541014519 putative translocon interaction site; other site 716541014520 signal recognition particle (SRP54) interaction site; other site 716541014521 L23 interface [polypeptide binding]; other site 716541014522 trigger factor interaction site; other site 716541014523 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 716541014524 23S rRNA interface [nucleotide binding]; other site 716541014525 5S rRNA interface [nucleotide binding]; other site 716541014526 putative antibiotic binding site [chemical binding]; other site 716541014527 L25 interface [polypeptide binding]; other site 716541014528 L27 interface [polypeptide binding]; other site 716541014529 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 716541014530 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 716541014531 G-X-X-G motif; other site 716541014532 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 716541014533 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 716541014534 protein-rRNA interface [nucleotide binding]; other site 716541014535 putative translocon binding site; other site 716541014536 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 716541014537 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 716541014538 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 716541014539 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 716541014540 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 716541014541 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 716541014542 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 716541014543 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 716541014544 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 716541014545 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 716541014546 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 716541014547 Ferritin-like domain; Region: Ferritin; pfam00210 716541014548 heme binding site [chemical binding]; other site 716541014549 ferroxidase pore; other site 716541014550 ferroxidase diiron center [ion binding]; other site 716541014551 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 716541014552 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 716541014553 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 716541014554 G1 box; other site 716541014555 GEF interaction site [polypeptide binding]; other site 716541014556 GTP/Mg2+ binding site [chemical binding]; other site 716541014557 Switch I region; other site 716541014558 G2 box; other site 716541014559 G3 box; other site 716541014560 Switch II region; other site 716541014561 G4 box; other site 716541014562 G5 box; other site 716541014563 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 716541014564 elongation factor G; Reviewed; Region: PRK00007 716541014565 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 716541014566 G1 box; other site 716541014567 putative GEF interaction site [polypeptide binding]; other site 716541014568 GTP/Mg2+ binding site [chemical binding]; other site 716541014569 Switch I region; other site 716541014570 G2 box; other site 716541014571 G3 box; other site 716541014572 Switch II region; other site 716541014573 G4 box; other site 716541014574 G5 box; other site 716541014575 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 716541014576 Elongation Factor G, domain II; Region: EFG_II; pfam14492 716541014577 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 716541014578 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 716541014579 30S ribosomal protein S7; Validated; Region: PRK05302 716541014580 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 716541014581 S17 interaction site [polypeptide binding]; other site 716541014582 S8 interaction site; other site 716541014583 16S rRNA interaction site [nucleotide binding]; other site 716541014584 streptomycin interaction site [chemical binding]; other site 716541014585 23S rRNA interaction site [nucleotide binding]; other site 716541014586 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 716541014587 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 716541014588 sulfur relay protein TusC; Validated; Region: PRK00211 716541014589 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 716541014590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 716541014591 YheO-like PAS domain; Region: PAS_6; pfam08348 716541014592 HTH domain; Region: HTH_22; pfam13309 716541014593 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 716541014594 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 716541014595 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 716541014596 phi X174 lysis protein; Provisional; Region: PRK02793 716541014597 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 716541014598 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 716541014599 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 716541014600 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 716541014601 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 716541014602 TrkA-N domain; Region: TrkA_N; pfam02254 716541014603 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 716541014604 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 716541014605 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716541014606 ABC transporter; Region: ABC_tran_2; pfam12848 716541014607 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 716541014608 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 716541014609 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541014610 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541014611 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541014612 dimerization interface [polypeptide binding]; other site 716541014613 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 716541014614 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 716541014615 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 716541014616 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 716541014617 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 716541014618 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 716541014619 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 716541014620 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 716541014621 Coenzyme A transferase; Region: CoA_trans; cl17247 716541014622 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 716541014623 putative hydrolase; Provisional; Region: PRK10985 716541014624 hypothetical protein; Provisional; Region: PRK04966 716541014625 phosphoribulokinase; Provisional; Region: PRK15453 716541014626 active site 716541014627 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541014628 hypothetical protein; Provisional; Region: PRK10738 716541014629 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 716541014630 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 716541014631 ligand binding site [chemical binding]; other site 716541014632 flexible hinge region; other site 716541014633 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 716541014634 putative switch regulator; other site 716541014635 non-specific DNA interactions [nucleotide binding]; other site 716541014636 DNA binding site [nucleotide binding] 716541014637 sequence specific DNA binding site [nucleotide binding]; other site 716541014638 putative cAMP binding site [chemical binding]; other site 716541014639 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 716541014640 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 716541014641 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 716541014642 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 716541014643 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 716541014644 inhibitor-cofactor binding pocket; inhibition site 716541014645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541014646 catalytic residue [active] 716541014647 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 716541014648 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 716541014649 glutamine binding [chemical binding]; other site 716541014650 catalytic triad [active] 716541014651 Protein of unknown function (DUF2559); Region: DUF2559; cl08097 716541014652 Fic/DOC family; Region: Fic; cl00960 716541014653 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 716541014654 substrate binding site [chemical binding]; other site 716541014655 putative transporter; Provisional; Region: PRK03699 716541014656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541014657 putative substrate translocation pore; other site 716541014658 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 716541014659 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 716541014660 active site 716541014661 nitrite reductase subunit NirD; Provisional; Region: PRK14989 716541014662 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716541014663 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 716541014664 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 716541014665 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 716541014666 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 716541014667 siroheme synthase; Provisional; Region: cysG; PRK10637 716541014668 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 716541014669 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 716541014670 Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414 716541014671 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 716541014672 active site 716541014673 SAM binding site [chemical binding]; other site 716541014674 homodimer interface [polypeptide binding]; other site 716541014675 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 716541014676 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 716541014677 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 716541014678 active site 716541014679 HIGH motif; other site 716541014680 dimer interface [polypeptide binding]; other site 716541014681 KMSKS motif; other site 716541014682 phosphoglycolate phosphatase; Provisional; Region: PRK13222 716541014683 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 716541014684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541014685 motif II; other site 716541014686 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 716541014687 substrate binding site [chemical binding]; other site 716541014688 hexamer interface [polypeptide binding]; other site 716541014689 metal binding site [ion binding]; metal-binding site 716541014690 DNA adenine methylase; Provisional; Region: PRK10904 716541014691 cell division protein DamX; Validated; Region: PRK10905 716541014692 Sporulation related domain; Region: SPOR; pfam05036 716541014693 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 716541014694 active site 716541014695 dimer interface [polypeptide binding]; other site 716541014696 metal binding site [ion binding]; metal-binding site 716541014697 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 716541014698 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 716541014699 ADP binding site [chemical binding]; other site 716541014700 magnesium binding site [ion binding]; other site 716541014701 putative shikimate binding site; other site 716541014702 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 716541014703 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 716541014704 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 716541014705 Fimbrial assembly protein (PilN); Region: PilN; cl19830 716541014706 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 716541014707 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 716541014708 Transglycosylase; Region: Transgly; pfam00912 716541014709 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 716541014710 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 716541014711 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 716541014712 ADP-ribose binding site [chemical binding]; other site 716541014713 dimer interface [polypeptide binding]; other site 716541014714 active site 716541014715 nudix motif; other site 716541014716 metal binding site [ion binding]; metal-binding site 716541014717 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 716541014718 GMP/IMP nucleotidase; Provisional; Region: PRK14988 716541014719 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 716541014720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541014721 motif II; other site 716541014722 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 716541014723 RNA binding surface [nucleotide binding]; other site 716541014724 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 716541014725 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 716541014726 dimerization interface [polypeptide binding]; other site 716541014727 domain crossover interface; other site 716541014728 redox-dependent activation switch; other site 716541014729 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 716541014730 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 716541014731 active site 716541014732 substrate-binding site [chemical binding]; other site 716541014733 metal-binding site [ion binding] 716541014734 ATP binding site [chemical binding]; other site 716541014735 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541014736 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 716541014737 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541014738 dimerization interface [polypeptide binding]; other site 716541014739 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541014740 dimer interface [polypeptide binding]; other site 716541014741 phosphorylation site [posttranslational modification] 716541014742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541014743 ATP binding site [chemical binding]; other site 716541014744 Mg2+ binding site [ion binding]; other site 716541014745 G-X-G motif; other site 716541014746 osmolarity response regulator; Provisional; Region: ompR; PRK09468 716541014747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541014748 active site 716541014749 phosphorylation site [posttranslational modification] 716541014750 intermolecular recognition site; other site 716541014751 dimerization interface [polypeptide binding]; other site 716541014752 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541014753 DNA binding site [nucleotide binding] 716541014754 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 716541014755 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 716541014756 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 716541014757 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 716541014758 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 716541014759 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 716541014760 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 716541014761 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 716541014762 RNA binding site [nucleotide binding]; other site 716541014763 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 716541014764 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 716541014765 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 716541014766 G1 box; other site 716541014767 GTP/Mg2+ binding site [chemical binding]; other site 716541014768 Switch I region; other site 716541014769 G2 box; other site 716541014770 G3 box; other site 716541014771 Switch II region; other site 716541014772 G4 box; other site 716541014773 G5 box; other site 716541014774 Nucleoside recognition; Region: Gate; pfam07670 716541014775 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 716541014776 Nucleoside recognition; Region: Gate; pfam07670 716541014777 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 716541014778 carboxylesterase BioH; Provisional; Region: PRK10349 716541014779 Putative lysophospholipase; Region: Hydrolase_4; cl19140 716541014780 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 716541014781 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 716541014782 active site 716541014783 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 716541014784 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 716541014785 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 716541014786 high-affinity gluconate transporter; Provisional; Region: PRK14984 716541014787 GntP family permease; Region: GntP_permease; pfam02447 716541014788 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 716541014789 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 716541014790 maltodextrin phosphorylase; Provisional; Region: PRK14985 716541014791 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 716541014792 active site pocket [active] 716541014793 transcriptional regulator MalT; Provisional; Region: PRK04841 716541014794 AAA ATPase domain; Region: AAA_16; pfam13191 716541014795 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541014796 DNA binding residues [nucleotide binding] 716541014797 dimerization interface [polypeptide binding]; other site 716541014798 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 716541014799 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 716541014800 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 716541014801 intramembrane serine protease GlpG; Provisional; Region: PRK10907 716541014802 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 716541014803 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 716541014804 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 716541014805 active site residue [active] 716541014806 FAD dependent oxidoreductase; Region: DAO; pfam01266 716541014807 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 716541014808 glycogen phosphorylase; Provisional; Region: PRK14986 716541014809 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 716541014810 homodimer interface [polypeptide binding]; other site 716541014811 active site pocket [active] 716541014812 glycogen synthase; Provisional; Region: glgA; PRK00654 716541014813 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 716541014814 ADP-binding pocket [chemical binding]; other site 716541014815 homodimer interface [polypeptide binding]; other site 716541014816 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 716541014817 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 716541014818 ligand binding site; other site 716541014819 oligomer interface; other site 716541014820 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 716541014821 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 716541014822 dimer interface [polypeptide binding]; other site 716541014823 N-terminal domain interface [polypeptide binding]; other site 716541014824 sulfate 1 binding site; other site 716541014825 glycogen debranching enzyme; Provisional; Region: PRK03705 716541014826 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 716541014827 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 716541014828 active site 716541014829 catalytic site [active] 716541014830 glycogen branching enzyme; Provisional; Region: PRK05402 716541014831 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 716541014832 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 716541014833 active site 716541014834 catalytic site [active] 716541014835 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 716541014836 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 716541014837 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 716541014838 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 716541014839 putative antibiotic transporter; Provisional; Region: PRK10739 716541014840 low affinity gluconate transporter; Provisional; Region: PRK10472 716541014841 GntP family permease; Region: GntP_permease; pfam02447 716541014842 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 716541014843 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 716541014844 ATP-binding site [chemical binding]; other site 716541014845 Gluconate-6-phosphate binding site [chemical binding]; other site 716541014846 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 716541014847 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541014848 DNA binding site [nucleotide binding] 716541014849 domain linker motif; other site 716541014850 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 716541014851 putative ligand binding site [chemical binding]; other site 716541014852 putative dimerization interface [polypeptide binding]; other site 716541014853 Pirin-related protein [General function prediction only]; Region: COG1741 716541014854 Pirin; Region: Pirin; pfam02678 716541014855 putative oxidoreductase; Provisional; Region: PRK10206 716541014856 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 716541014857 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 716541014858 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 716541014859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541014860 Coenzyme A binding pocket [chemical binding]; other site 716541014861 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 716541014862 hypothetical protein; Provisional; Region: PRK10350 716541014863 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 716541014864 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 716541014865 putative active site [active] 716541014866 catalytic site [active] 716541014867 putative metal binding site [ion binding]; other site 716541014868 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 716541014869 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 716541014870 Walker A/P-loop; other site 716541014871 ATP binding site [chemical binding]; other site 716541014872 Q-loop/lid; other site 716541014873 ABC transporter signature motif; other site 716541014874 Walker B; other site 716541014875 D-loop; other site 716541014876 H-loop/switch region; other site 716541014877 TOBE domain; Region: TOBE_2; pfam08402 716541014878 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 716541014879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541014880 dimer interface [polypeptide binding]; other site 716541014881 conserved gate region; other site 716541014882 putative PBP binding loops; other site 716541014883 ABC-ATPase subunit interface; other site 716541014884 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 716541014885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541014886 dimer interface [polypeptide binding]; other site 716541014887 conserved gate region; other site 716541014888 putative PBP binding loops; other site 716541014889 ABC-ATPase subunit interface; other site 716541014890 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 716541014891 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 716541014892 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 716541014893 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 716541014894 Walker A/P-loop; other site 716541014895 ATP binding site [chemical binding]; other site 716541014896 Q-loop/lid; other site 716541014897 ABC transporter signature motif; other site 716541014898 Walker B; other site 716541014899 D-loop; other site 716541014900 H-loop/switch region; other site 716541014901 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 716541014902 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 716541014903 Walker A/P-loop; other site 716541014904 ATP binding site [chemical binding]; other site 716541014905 Q-loop/lid; other site 716541014906 ABC transporter signature motif; other site 716541014907 Walker B; other site 716541014908 D-loop; other site 716541014909 H-loop/switch region; other site 716541014910 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 716541014911 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 716541014912 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 716541014913 TM-ABC transporter signature motif; other site 716541014914 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 716541014915 TM-ABC transporter signature motif; other site 716541014916 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 716541014917 dimerization interface [polypeptide binding]; other site 716541014918 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 716541014919 ligand binding site [chemical binding]; other site 716541014920 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 716541014921 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 716541014922 dimerization interface [polypeptide binding]; other site 716541014923 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 716541014924 ligand binding site [chemical binding]; other site 716541014925 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 716541014926 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 716541014927 inhibitor-cofactor binding pocket; inhibition site 716541014928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541014929 catalytic residue [active] 716541014930 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 716541014931 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 716541014932 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 716541014933 DNA binding residues [nucleotide binding] 716541014934 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 716541014935 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 716541014936 cell division protein FtsE; Provisional; Region: PRK10908 716541014937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 716541014938 Walker A/P-loop; other site 716541014939 ATP binding site [chemical binding]; other site 716541014940 Q-loop/lid; other site 716541014941 ABC transporter signature motif; other site 716541014942 Walker B; other site 716541014943 D-loop; other site 716541014944 H-loop/switch region; other site 716541014945 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 716541014946 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 716541014947 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 716541014948 P loop; other site 716541014949 GTP binding site [chemical binding]; other site 716541014950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541014951 S-adenosylmethionine binding site [chemical binding]; other site 716541014952 hypothetical protein; Provisional; Region: PRK10910 716541014953 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 716541014954 Predicted membrane protein [Function unknown]; Region: COG3714 716541014955 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 716541014956 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 716541014957 metal-binding site [ion binding] 716541014958 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 716541014959 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 716541014960 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 716541014961 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 716541014962 DctM-like transporters; Region: DctM; pfam06808 716541014963 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 716541014964 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 716541014965 CPxP motif; other site 716541014966 hypothetical protein; Provisional; Region: PRK11212 716541014967 hypothetical protein; Provisional; Region: PRK11615 716541014968 major facilitator superfamily transporter; Provisional; Region: PRK05122 716541014969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541014970 putative substrate translocation pore; other site 716541014971 Domain of unknown function DUF20; Region: UPF0118; cl00465 716541014972 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 716541014973 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 716541014974 putative acyl-acceptor binding pocket; other site 716541014975 Phosphopantetheine attachment site; Region: PP-binding; cl09936 716541014976 acyl carrier protein; Provisional; Region: PRK05350 716541014977 Predicted membrane protein [Function unknown]; Region: COG4648 716541014978 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 716541014979 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 716541014980 acyl-activating enzyme (AAE) consensus motif; other site 716541014981 active site 716541014982 AMP binding site [chemical binding]; other site 716541014983 CoA binding site [chemical binding]; other site 716541014984 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 716541014985 active site 2 [active] 716541014986 active site 1 [active] 716541014987 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 716541014988 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 716541014989 Ligand binding site; other site 716541014990 Putative Catalytic site; other site 716541014991 DXD motif; other site 716541014992 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 716541014993 putative acyl-acceptor binding pocket; other site 716541014994 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 716541014995 active site 716541014996 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 716541014997 Predicted exporter [General function prediction only]; Region: COG4258 716541014998 MMPL family; Region: MMPL; cl14618 716541014999 MMPL family; Region: MMPL; cl14618 716541015000 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 716541015001 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 716541015002 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 716541015003 dimer interface [polypeptide binding]; other site 716541015004 active site 716541015005 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 716541015006 active site 2 [active] 716541015007 active site 1 [active] 716541015008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716541015009 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 716541015010 NAD(P) binding site [chemical binding]; other site 716541015011 active site 716541015012 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 716541015013 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 716541015014 dimer interface [polypeptide binding]; other site 716541015015 active site 716541015016 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 716541015017 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 716541015018 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 716541015019 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 716541015020 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 716541015021 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 716541015022 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 716541015023 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 716541015024 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 716541015025 active site 716541015026 substrate binding site [chemical binding]; other site 716541015027 cosubstrate binding site; other site 716541015028 catalytic site [active] 716541015029 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 716541015030 active site 716541015031 hexamer interface [polypeptide binding]; other site 716541015032 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 716541015033 NAD binding site [chemical binding]; other site 716541015034 substrate binding site [chemical binding]; other site 716541015035 active site 716541015036 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 716541015037 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 716541015038 Ligand binding site; other site 716541015039 Putative Catalytic site; other site 716541015040 DXD motif; other site 716541015041 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 716541015042 inhibitor-cofactor binding pocket; inhibition site 716541015043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541015044 catalytic residue [active] 716541015045 Phenolic Acid Decarboxylase; Region: PAD; cd14241 716541015046 active site 716541015047 dimer interface [polypeptide binding]; other site 716541015048 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541015049 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541015050 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541015051 dimerization interface [polypeptide binding]; other site 716541015052 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 716541015053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716541015054 NAD(P) binding site [chemical binding]; other site 716541015055 active site 716541015056 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 716541015057 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 716541015058 Integral membrane protein TerC family; Region: TerC; cl10468 716541015059 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 716541015060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541015061 putative substrate translocation pore; other site 716541015062 Transcriptional regulator [Transcription]; Region: IclR; COG1414 716541015063 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 716541015064 Bacterial transcriptional regulator; Region: IclR; pfam01614 716541015065 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 716541015066 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 716541015067 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 716541015068 NAD binding site [chemical binding]; other site 716541015069 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 716541015070 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541015071 dimerization interface [polypeptide binding]; other site 716541015072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541015073 dimer interface [polypeptide binding]; other site 716541015074 phosphorylation site [posttranslational modification] 716541015075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541015076 ATP binding site [chemical binding]; other site 716541015077 Mg2+ binding site [ion binding]; other site 716541015078 G-X-G motif; other site 716541015079 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 716541015080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541015081 active site 716541015082 phosphorylation site [posttranslational modification] 716541015083 intermolecular recognition site; other site 716541015084 dimerization interface [polypeptide binding]; other site 716541015085 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541015086 DNA binding site [nucleotide binding] 716541015087 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 716541015088 CopC domain; Region: CopC; pfam04234 716541015089 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 716541015090 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 716541015091 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 716541015092 The first cupredoxin domain of CopA copper resistance protein family; Region: CuRO_1_CopA; cd13848 716541015093 putative Domain 2 interface [polypeptide binding]; other site 716541015094 putative Domain 3 interface [polypeptide binding]; other site 716541015095 trinuclear Cu binding site [ion binding]; other site 716541015096 The second cupredoxin domain of CopA copper resistance protein family; Region: CuRO_2_CopA; cd13874 716541015097 putative Domain 1 interface [polypeptide binding]; other site 716541015098 putative Domain 3 interface [polypeptide binding]; other site 716541015099 The third cupredoxin domain of CopA copper resistance protein family; Region: CuRO_3_CopA; cd13896 716541015100 putative Domain 2 interface [polypeptide binding]; other site 716541015101 Type 1 (T1) Cu binding site [ion binding]; other site 716541015102 putative Domain 1 interface [polypeptide binding]; other site 716541015103 trinuclear Cu binding site [ion binding]; other site 716541015104 Peptidase family M23; Region: Peptidase_M23; pfam01551 716541015105 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 716541015106 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 716541015107 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 716541015108 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541015109 motif II; other site 716541015110 Protein of unknown function, DUF; Region: DUF411; cl01142 716541015111 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 716541015112 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 716541015113 HlyD family secretion protein; Region: HlyD_3; pfam13437 716541015114 periplasmic copper-binding protein; Provisional; Region: PRK09838 716541015115 Outer membrane efflux protein; Region: OEP; pfam02321 716541015116 Transposase; Region: HTH_Tnp_1; cl17663 716541015117 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541015118 IS2 transposase TnpB; Reviewed; Region: PRK09409 716541015119 HTH-like domain; Region: HTH_21; pfam13276 716541015120 Integrase core domain; Region: rve; pfam00665 716541015121 Integrase core domain; Region: rve_3; pfam13683 716541015122 Outer membrane efflux protein; Region: OEP; pfam02321 716541015123 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 716541015124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541015125 active site 716541015126 phosphorylation site [posttranslational modification] 716541015127 intermolecular recognition site; other site 716541015128 dimerization interface [polypeptide binding]; other site 716541015129 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541015130 DNA binding site [nucleotide binding] 716541015131 sensor kinase CusS; Provisional; Region: PRK09835 716541015132 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541015133 dimerization interface [polypeptide binding]; other site 716541015134 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541015135 dimer interface [polypeptide binding]; other site 716541015136 phosphorylation site [posttranslational modification] 716541015137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541015138 ATP binding site [chemical binding]; other site 716541015139 Mg2+ binding site [ion binding]; other site 716541015140 G-X-G motif; other site 716541015141 Domain of unknown function (DUF305); Region: DUF305; cl17794 716541015142 AAA ATPase domain; Region: AAA_15; pfam13175 716541015143 AAA domain; Region: AAA_23; pfam13476 716541015144 Walker A/P-loop; other site 716541015145 ATP binding site [chemical binding]; other site 716541015146 AAA domain; Region: AAA_21; pfam13304 716541015147 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 716541015148 active site 716541015149 metal binding site [ion binding]; metal-binding site 716541015150 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 716541015151 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 716541015152 TniQ; Region: TniQ; pfam06527 716541015153 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 716541015154 AAA domain; Region: AAA_22; pfam13401 716541015155 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 716541015156 Predicted flavoproteins [General function prediction only]; Region: COG2081 716541015157 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541015158 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 716541015159 universal stress protein UspB; Provisional; Region: PRK04960 716541015160 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 716541015161 Ligand Binding Site [chemical binding]; other site 716541015162 putative methyltransferase; Provisional; Region: PRK10742 716541015163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541015164 S-adenosylmethionine binding site [chemical binding]; other site 716541015165 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 716541015166 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 716541015167 active site 716541015168 Zn binding site [ion binding]; other site 716541015169 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 716541015170 glutathione reductase; Validated; Region: PRK06116 716541015171 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 716541015172 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716541015173 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 716541015174 trehalase; Provisional; Region: treF; PRK13270 716541015175 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 716541015176 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 716541015177 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541015178 Coenzyme A binding pocket [chemical binding]; other site 716541015179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 716541015180 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 716541015181 catalytic residue [active] 716541015182 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 716541015183 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 716541015184 DNA binding residues [nucleotide binding] 716541015185 dimerization interface [polypeptide binding]; other site 716541015186 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 716541015187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 716541015188 NAD(P) binding site [chemical binding]; other site 716541015189 active site 716541015190 Transcriptional regulator [Transcription]; Region: LysR; COG0583 716541015191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541015192 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 716541015193 putative effector binding pocket; other site 716541015194 putative dimerization interface [polypeptide binding]; other site 716541015195 inner membrane protein YhjD; Region: TIGR00766 716541015196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541015197 metabolite-proton symporter; Region: 2A0106; TIGR00883 716541015198 putative substrate translocation pore; other site 716541015199 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 716541015200 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 716541015201 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541015202 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 716541015203 substrate binding site [chemical binding]; other site 716541015204 ATP binding site [chemical binding]; other site 716541015205 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 716541015206 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 716541015207 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 716541015208 putative diguanylate cyclase; Provisional; Region: PRK13561 716541015209 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541015210 dimerization interface [polypeptide binding]; other site 716541015211 diguanylate cyclase; Region: GGDEF; smart00267 716541015212 nucleotidyl binding site; other site 716541015213 metal binding site [ion binding]; metal-binding site 716541015214 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 716541015215 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 716541015216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 716541015217 binding surface 716541015218 TPR motif; other site 716541015219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 716541015220 binding surface 716541015221 TPR motif; other site 716541015222 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 716541015223 endo-1,4-D-glucanase; Provisional; Region: PRK11097 716541015224 cellulose synthase regulator protein; Provisional; Region: PRK11114 716541015225 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 716541015226 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 716541015227 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 716541015228 DXD motif; other site 716541015229 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 716541015230 PilZ domain; Region: PilZ; pfam07238 716541015231 cell division protein; Provisional; Region: PRK10037 716541015232 YhjQ protein; Region: YhjQ; pfam06564 716541015233 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 716541015234 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 716541015235 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 716541015236 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 716541015237 Biotin operon repressor [Transcription]; Region: BirA; COG1654 716541015238 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 716541015239 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 716541015240 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 716541015241 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 716541015242 FAD binding domain; Region: FAD_binding_4; pfam01565 716541015243 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 716541015244 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 716541015245 potassium transporter; Provisional; Region: PRK10750 716541015246 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 716541015247 hypothetical protein; Provisional; Region: PRK11568 716541015248 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 716541015249 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 716541015250 proline dipeptidase; Provisional; Region: PRK13607 716541015251 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 716541015252 active site 716541015253 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 716541015254 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 716541015255 substrate binding site [chemical binding]; other site 716541015256 oxyanion hole (OAH) forming residues; other site 716541015257 trimer interface [polypeptide binding]; other site 716541015258 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 716541015259 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 716541015260 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 716541015261 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 716541015262 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 716541015263 dimer interface [polypeptide binding]; other site 716541015264 active site 716541015265 FMN reductase; Validated; Region: fre; PRK08051 716541015266 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 716541015267 FAD binding pocket [chemical binding]; other site 716541015268 FAD binding motif [chemical binding]; other site 716541015269 phosphate binding motif [ion binding]; other site 716541015270 beta-alpha-beta structure motif; other site 716541015271 NAD binding pocket [chemical binding]; other site 716541015272 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 716541015273 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 716541015274 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 716541015275 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 716541015276 active site 716541015277 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 716541015278 sec-independent translocase; Provisional; Region: PRK01770 716541015279 sec-independent translocase; Provisional; Region: tatB; PRK00404 716541015280 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 716541015281 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 716541015282 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 716541015283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 716541015284 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 716541015285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541015286 S-adenosylmethionine binding site [chemical binding]; other site 716541015287 DNA recombination protein RmuC; Provisional; Region: PRK10361 716541015288 RmuC family; Region: RmuC; pfam02646 716541015289 uridine phosphorylase; Provisional; Region: PRK11178 716541015290 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 716541015291 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 716541015292 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 716541015293 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 716541015294 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 716541015295 THF binding site; other site 716541015296 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 716541015297 substrate binding site [chemical binding]; other site 716541015298 THF binding site; other site 716541015299 zinc-binding site [ion binding]; other site 716541015300 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 716541015301 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541015302 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 716541015303 putative dimerization interface [polypeptide binding]; other site 716541015304 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 716541015305 putative hydrolase; Provisional; Region: PRK10976 716541015306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541015307 active site 716541015308 motif I; other site 716541015309 motif II; other site 716541015310 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 716541015311 lysophospholipase L2; Provisional; Region: PRK10749 716541015312 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 716541015313 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 716541015314 threonine efflux system; Provisional; Region: PRK10229 716541015315 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 716541015316 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716541015317 ATP binding site [chemical binding]; other site 716541015318 putative Mg++ binding site [ion binding]; other site 716541015319 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716541015320 nucleotide binding region [chemical binding]; other site 716541015321 ATP-binding site [chemical binding]; other site 716541015322 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 716541015323 HRDC domain; Region: HRDC; pfam00570 716541015324 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 716541015325 dimerization interface [polypeptide binding]; other site 716541015326 substrate binding site [chemical binding]; other site 716541015327 active site 716541015328 calcium binding site [ion binding]; other site 716541015329 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 716541015330 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 716541015331 CoenzymeA binding site [chemical binding]; other site 716541015332 subunit interaction site [polypeptide binding]; other site 716541015333 PHB binding site; other site 716541015334 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 716541015335 EamA-like transporter family; Region: EamA; pfam00892 716541015336 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 716541015337 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 716541015338 Cl binding site [ion binding]; other site 716541015339 oligomer interface [polypeptide binding]; other site 716541015340 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 716541015341 Part of AAA domain; Region: AAA_19; pfam13245 716541015342 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 716541015343 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 716541015344 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 716541015345 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541015346 motif II; other site 716541015347 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 716541015348 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 716541015349 active site 716541015350 Int/Topo IB signature motif; other site 716541015351 hypothetical protein; Provisional; Region: PRK10963 716541015352 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 716541015353 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 716541015354 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 716541015355 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 716541015356 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 716541015357 putative iron binding site [ion binding]; other site 716541015358 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 716541015359 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 716541015360 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 716541015361 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 716541015362 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 716541015363 domain interfaces; other site 716541015364 active site 716541015365 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 716541015366 active site 716541015367 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 716541015368 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 716541015369 HemY protein N-terminus; Region: HemY_N; pfam07219 716541015370 Tetratricopeptide repeat; Region: TPR_2; pfam07719 716541015371 putative transport protein YifK; Provisional; Region: PRK10746 716541015372 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 716541015373 putative common antigen polymerase; Provisional; Region: PRK02975 716541015374 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 716541015375 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 716541015376 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 716541015377 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 716541015378 inhibitor-cofactor binding pocket; inhibition site 716541015379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541015380 catalytic residue [active] 716541015381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541015382 Coenzyme A binding pocket [chemical binding]; other site 716541015383 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 716541015384 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 716541015385 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 716541015386 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 716541015387 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 716541015388 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 716541015389 homodimer interface [polypeptide binding]; other site 716541015390 active site 716541015391 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 716541015392 Chain length determinant protein; Region: Wzz; pfam02706 716541015393 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 716541015394 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 716541015395 Mg++ binding site [ion binding]; other site 716541015396 putative catalytic motif [active] 716541015397 substrate binding site [chemical binding]; other site 716541015398 transcription termination factor Rho; Provisional; Region: rho; PRK09376 716541015399 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 716541015400 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 716541015401 RNA binding site [nucleotide binding]; other site 716541015402 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 716541015403 multimer interface [polypeptide binding]; other site 716541015404 Walker A motif; other site 716541015405 ATP binding site [chemical binding]; other site 716541015406 Walker B motif; other site 716541015407 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 716541015408 catalytic residues [active] 716541015409 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 716541015410 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 716541015411 ATP binding site [chemical binding]; other site 716541015412 Mg++ binding site [ion binding]; other site 716541015413 motif III; other site 716541015414 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 716541015415 nucleotide binding region [chemical binding]; other site 716541015416 ATP-binding site [chemical binding]; other site 716541015417 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 716541015418 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 716541015419 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 716541015420 Part of AAA domain; Region: AAA_19; pfam13245 716541015421 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 716541015422 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 716541015423 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 716541015424 ketol-acid reductoisomerase; Validated; Region: PRK05225 716541015425 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 716541015426 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 716541015427 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541015428 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 716541015429 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 716541015430 putative dimerization interface [polypeptide binding]; other site 716541015431 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 716541015432 threonine dehydratase; Reviewed; Region: PRK09224 716541015433 tetramer interface [polypeptide binding]; other site 716541015434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541015435 catalytic residue [active] 716541015436 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 716541015437 putative Ile/Val binding site [chemical binding]; other site 716541015438 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 716541015439 putative Ile/Val binding site [chemical binding]; other site 716541015440 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 716541015441 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 716541015442 homodimer interface [polypeptide binding]; other site 716541015443 substrate-cofactor binding pocket; other site 716541015444 catalytic residue [active] 716541015445 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 716541015446 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 716541015447 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 716541015448 PYR/PP interface [polypeptide binding]; other site 716541015449 dimer interface [polypeptide binding]; other site 716541015450 TPP binding site [chemical binding]; other site 716541015451 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 716541015452 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 716541015453 TPP-binding site [chemical binding]; other site 716541015454 dimer interface [polypeptide binding]; other site 716541015455 putative ATP-dependent protease; Provisional; Region: PRK09862 716541015456 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 716541015457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541015458 Walker A motif; other site 716541015459 ATP binding site [chemical binding]; other site 716541015460 Walker B motif; other site 716541015461 arginine finger; other site 716541015462 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 716541015463 hypothetical protein; Provisional; Region: PRK11027 716541015464 IS2 transposase TnpB; Reviewed; Region: PRK09409 716541015465 HTH-like domain; Region: HTH_21; pfam13276 716541015466 Integrase core domain; Region: rve; pfam00665 716541015467 Integrase core domain; Region: rve_3; pfam13683 716541015468 Transposase; Region: HTH_Tnp_1; cl17663 716541015469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 716541015470 transcriptional regulator HdfR; Provisional; Region: PRK03601 716541015471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541015472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541015473 dimerization interface [polypeptide binding]; other site 716541015474 glutamate racemase; Provisional; Region: PRK00865 716541015475 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 716541015476 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 716541015477 N-terminal plug; other site 716541015478 ligand-binding site [chemical binding]; other site 716541015479 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 716541015480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541015481 S-adenosylmethionine binding site [chemical binding]; other site 716541015482 hypothetical protein; Provisional; Region: PRK11056 716541015483 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 716541015484 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 716541015485 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 716541015486 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 716541015487 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 716541015488 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 716541015489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 716541015490 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 716541015491 dimerization interface [polypeptide binding]; other site 716541015492 argininosuccinate lyase; Provisional; Region: PRK04833 716541015493 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 716541015494 active sites [active] 716541015495 tetramer interface [polypeptide binding]; other site 716541015496 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 716541015497 nucleotide binding site [chemical binding]; other site 716541015498 N-acetyl-L-glutamate binding site [chemical binding]; other site 716541015499 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 716541015500 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 716541015501 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 716541015502 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 716541015503 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 716541015504 metal binding site [ion binding]; metal-binding site 716541015505 putative dimer interface [polypeptide binding]; other site 716541015506 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 716541015507 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 716541015508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541015509 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 716541015510 active site 716541015511 intersubunit interactions; other site 716541015512 catalytic residue [active] 716541015513 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 716541015514 dimer interface [polypeptide binding]; other site 716541015515 active site 716541015516 metal binding site [ion binding]; metal-binding site 716541015517 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 716541015518 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 716541015519 heme binding site [chemical binding]; other site 716541015520 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 716541015521 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 716541015522 FAD binding site [chemical binding]; other site 716541015523 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 716541015524 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 716541015525 putative catalytic residues [active] 716541015526 putative nucleotide binding site [chemical binding]; other site 716541015527 putative aspartate binding site [chemical binding]; other site 716541015528 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 716541015529 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 716541015530 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 716541015531 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 716541015532 homodimer interface [polypeptide binding]; other site 716541015533 substrate-cofactor binding pocket; other site 716541015534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 716541015535 catalytic residue [active] 716541015536 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 716541015537 dimerization interface [polypeptide binding]; other site 716541015538 DNA binding site [nucleotide binding] 716541015539 corepressor binding sites; other site 716541015540 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 716541015541 primosome assembly protein PriA; Validated; Region: PRK05580 716541015542 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 716541015543 ATP binding site [chemical binding]; other site 716541015544 putative Mg++ binding site [ion binding]; other site 716541015545 helicase superfamily c-terminal domain; Region: HELICc; smart00490 716541015546 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541015547 DNA binding site [nucleotide binding] 716541015548 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 716541015549 domain linker motif; other site 716541015550 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 716541015551 dimerization interface [polypeptide binding]; other site 716541015552 ligand binding site [chemical binding]; other site 716541015553 essential cell division protein FtsN; Provisional; Region: PRK10927 716541015554 Sporulation related domain; Region: SPOR; pfam05036 716541015555 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 716541015556 active site 716541015557 HslU subunit interaction site [polypeptide binding]; other site 716541015558 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 716541015559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541015560 Walker A motif; other site 716541015561 ATP binding site [chemical binding]; other site 716541015562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541015563 Walker B motif; other site 716541015564 arginine finger; other site 716541015565 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 716541015566 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 716541015567 putative active site [active] 716541015568 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 716541015569 septal ring assembly protein ZapB; Provisional; Region: PRK15422 716541015570 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 716541015571 amphipathic channel; other site 716541015572 Asn-Pro-Ala signature motifs; other site 716541015573 glycerol kinase; Provisional; Region: glpK; PRK00047 716541015574 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 716541015575 N- and C-terminal domain interface [polypeptide binding]; other site 716541015576 active site 716541015577 MgATP binding site [chemical binding]; other site 716541015578 catalytic site [active] 716541015579 metal binding site [ion binding]; metal-binding site 716541015580 glycerol binding site [chemical binding]; other site 716541015581 homotetramer interface [polypeptide binding]; other site 716541015582 homodimer interface [polypeptide binding]; other site 716541015583 FBP binding site [chemical binding]; other site 716541015584 protein IIAGlc interface [polypeptide binding]; other site 716541015585 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 716541015586 putative active site [active] 716541015587 ferredoxin-NADP reductase; Provisional; Region: PRK10926 716541015588 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 716541015589 FAD binding pocket [chemical binding]; other site 716541015590 FAD binding motif [chemical binding]; other site 716541015591 phosphate binding motif [ion binding]; other site 716541015592 beta-alpha-beta structure motif; other site 716541015593 NAD binding pocket [chemical binding]; other site 716541015594 Predicted membrane protein [Function unknown]; Region: COG3152 716541015595 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 716541015596 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 716541015597 substrate binding site [chemical binding]; other site 716541015598 dimer interface [polypeptide binding]; other site 716541015599 catalytic triad [active] 716541015600 anion transporter; Region: dass; TIGR00785 716541015601 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 716541015602 transmembrane helices; other site 716541015603 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 716541015604 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541015605 substrate binding pocket [chemical binding]; other site 716541015606 membrane-bound complex binding site; other site 716541015607 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 716541015608 active site 716541015609 ADP/pyrophosphate binding site [chemical binding]; other site 716541015610 dimerization interface [polypeptide binding]; other site 716541015611 allosteric effector site; other site 716541015612 fructose-1,6-bisphosphate binding site; other site 716541015613 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 716541015614 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 716541015615 dimer interface [polypeptide binding]; other site 716541015616 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 716541015617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541015618 intermolecular recognition site; other site 716541015619 active site 716541015620 dimerization interface [polypeptide binding]; other site 716541015621 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 716541015622 DNA binding site [nucleotide binding] 716541015623 two-component sensor protein; Provisional; Region: cpxA; PRK09470 716541015624 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 716541015625 dimerization interface [polypeptide binding]; other site 716541015626 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541015627 dimer interface [polypeptide binding]; other site 716541015628 phosphorylation site [posttranslational modification] 716541015629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541015630 ATP binding site [chemical binding]; other site 716541015631 Mg2+ binding site [ion binding]; other site 716541015632 G-X-G motif; other site 716541015633 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 716541015634 MOSC domain; Region: MOSC; pfam03473 716541015635 3-alpha domain; Region: 3-alpha; pfam03475 716541015636 superoxide dismutase; Provisional; Region: PRK10925 716541015637 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 716541015638 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 716541015639 Sugar transport protein; Region: Sugar_transport; cl19288 716541015640 transcriptional activator RhaR; Provisional; Region: PRK13502 716541015641 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 716541015642 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541015643 transcriptional activator RhaS; Provisional; Region: PRK13503 716541015644 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 716541015645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541015646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 716541015647 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 716541015648 N- and C-terminal domain interface [polypeptide binding]; other site 716541015649 active site 716541015650 putative catalytic site [active] 716541015651 metal binding site [ion binding]; metal-binding site 716541015652 ATP binding site [chemical binding]; other site 716541015653 rhamnulokinase; Provisional; Region: rhaB; PRK10640 716541015654 carbohydrate binding site [chemical binding]; other site 716541015655 L-rhamnose isomerase; Provisional; Region: PRK01076 716541015656 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 716541015657 intersubunit interface [polypeptide binding]; other site 716541015658 active site 716541015659 Zn2+ binding site [ion binding]; other site 716541015660 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 716541015661 dimer interface [polypeptide binding]; other site 716541015662 active site 716541015663 metal binding site [ion binding]; metal-binding site 716541015664 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 716541015665 galactoside permease; Reviewed; Region: lacY; PRK09528 716541015666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541015667 putative substrate translocation pore; other site 716541015668 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 716541015669 Melibiase; Region: Melibiase; pfam02065 716541015670 Transcriptional regulators [Transcription]; Region: PurR; COG1609 716541015671 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541015672 DNA binding site [nucleotide binding] 716541015673 domain linker motif; other site 716541015674 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 716541015675 ligand binding site [chemical binding]; other site 716541015676 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 716541015677 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541015678 non-specific DNA binding site [nucleotide binding]; other site 716541015679 salt bridge; other site 716541015680 sequence-specific DNA binding site [nucleotide binding]; other site 716541015681 Cupin domain; Region: Cupin_2; cl17218 716541015682 AzlC protein; Region: AzlC; cl00570 716541015683 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 716541015684 hypothetical protein; Provisional; Region: PRK15301 716541015685 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 716541015686 PapC N-terminal domain; Region: PapC_N; pfam13954 716541015687 Outer membrane usher protein; Region: Usher; pfam00577 716541015688 PapC C-terminal domain; Region: PapC_C; pfam13953 716541015689 putative fimbrial chaperone protein; Provisional; Region: PRK09918 716541015690 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 716541015691 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 716541015692 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 716541015693 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 716541015694 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 716541015695 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 716541015696 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 716541015697 molybdopterin cofactor binding site; other site 716541015698 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 716541015699 molybdopterin cofactor binding site; other site 716541015700 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 716541015701 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 716541015702 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 716541015703 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 716541015704 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 716541015705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 716541015706 non-specific DNA binding site [nucleotide binding]; other site 716541015707 salt bridge; other site 716541015708 sequence-specific DNA binding site [nucleotide binding]; other site 716541015709 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 716541015710 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 716541015711 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 716541015712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 716541015713 Coenzyme A binding pocket [chemical binding]; other site 716541015714 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 716541015715 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 716541015716 putative active site [active] 716541015717 dimerization interface [polypeptide binding]; other site 716541015718 putative tRNAtyr binding site [nucleotide binding]; other site 716541015719 hypothetical protein; Reviewed; Region: PRK01637 716541015720 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 716541015721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541015722 motif II; other site 716541015723 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 716541015724 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716541015725 putative DNA binding site [nucleotide binding]; other site 716541015726 putative Zn2+ binding site [ion binding]; other site 716541015727 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 716541015728 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 716541015729 substrate binding site [chemical binding]; other site 716541015730 ATP binding site [chemical binding]; other site 716541015731 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 716541015732 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 716541015733 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 716541015734 Class I aldolases; Region: Aldolase_Class_I; cl17187 716541015735 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 716541015736 dimerization interface [polypeptide binding]; other site 716541015737 putative active cleft [active] 716541015738 alpha-glucosidase; Provisional; Region: PRK10426 716541015739 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 716541015740 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 716541015741 putative active site [active] 716541015742 putative catalytic site [active] 716541015743 putative symporter YagG; Provisional; Region: PRK09669; cl15392 716541015744 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 716541015745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541015746 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 716541015747 putative symporter YagG; Provisional; Region: PRK09669; cl15392 716541015748 outer membrane porin L; Provisional; Region: ompL; PRK09980 716541015749 GTP-binding protein; Provisional; Region: PRK10218 716541015750 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 716541015751 G1 box; other site 716541015752 putative GEF interaction site [polypeptide binding]; other site 716541015753 GTP/Mg2+ binding site [chemical binding]; other site 716541015754 Switch I region; other site 716541015755 G2 box; other site 716541015756 G3 box; other site 716541015757 Switch II region; other site 716541015758 G4 box; other site 716541015759 G5 box; other site 716541015760 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 716541015761 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 716541015762 glutamine synthetase; Provisional; Region: glnA; PRK09469 716541015763 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 716541015764 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 716541015765 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 716541015766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 716541015767 putative active site [active] 716541015768 heme pocket [chemical binding]; other site 716541015769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 716541015770 dimer interface [polypeptide binding]; other site 716541015771 phosphorylation site [posttranslational modification] 716541015772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 716541015773 ATP binding site [chemical binding]; other site 716541015774 Mg2+ binding site [ion binding]; other site 716541015775 G-X-G motif; other site 716541015776 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 716541015777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 716541015778 active site 716541015779 phosphorylation site [posttranslational modification] 716541015780 intermolecular recognition site; other site 716541015781 dimerization interface [polypeptide binding]; other site 716541015782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541015783 Walker A motif; other site 716541015784 ATP binding site [chemical binding]; other site 716541015785 Walker B motif; other site 716541015786 arginine finger; other site 716541015787 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 716541015788 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 716541015789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 716541015790 FeS/SAM binding site; other site 716541015791 HemN C-terminal domain; Region: HemN_C; pfam06969 716541015792 Der GTPase activator; Provisional; Region: PRK05244 716541015793 Predicted GTPase [General function prediction only]; Region: COG0218 716541015794 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 716541015795 G1 box; other site 716541015796 GTP/Mg2+ binding site [chemical binding]; other site 716541015797 Switch I region; other site 716541015798 G2 box; other site 716541015799 G3 box; other site 716541015800 Switch II region; other site 716541015801 G4 box; other site 716541015802 G5 box; other site 716541015803 DNA polymerase I; Provisional; Region: PRK05755 716541015804 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 716541015805 active site 716541015806 metal binding site 1 [ion binding]; metal-binding site 716541015807 putative 5' ssDNA interaction site; other site 716541015808 metal binding site 3; metal-binding site 716541015809 metal binding site 2 [ion binding]; metal-binding site 716541015810 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 716541015811 putative DNA binding site [nucleotide binding]; other site 716541015812 putative metal binding site [ion binding]; other site 716541015813 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 716541015814 active site 716541015815 catalytic site [active] 716541015816 substrate binding site [chemical binding]; other site 716541015817 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 716541015818 active site 716541015819 DNA binding site [nucleotide binding] 716541015820 catalytic site [active] 716541015821 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 716541015822 putative acyl-acceptor binding pocket; other site 716541015823 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 716541015824 catalytic residues [active] 716541015825 hinge region; other site 716541015826 alpha helical domain; other site 716541015827 serine/threonine protein kinase; Provisional; Region: PRK11768 716541015828 Phosphotransferase enzyme family; Region: APH; pfam01636 716541015829 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 716541015830 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 716541015831 GTP binding site; other site 716541015832 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 716541015833 Walker A motif; other site 716541015834 Transcriptional regulators [Transcription]; Region: FadR; COG2186 716541015835 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 716541015836 DNA-binding site [nucleotide binding]; DNA binding site 716541015837 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 716541015838 putative transporter; Provisional; Region: PRK10504 716541015839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 716541015840 putative substrate translocation pore; other site 716541015841 transcriptional repressor RbsR; Provisional; Region: PRK10423 716541015842 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 716541015843 DNA binding site [nucleotide binding] 716541015844 domain linker motif; other site 716541015845 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 716541015846 dimerization interface [polypeptide binding]; other site 716541015847 ligand binding site [chemical binding]; other site 716541015848 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 716541015849 substrate binding site [chemical binding]; other site 716541015850 dimer interface [polypeptide binding]; other site 716541015851 ATP binding site [chemical binding]; other site 716541015852 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 716541015853 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 716541015854 ligand binding site [chemical binding]; other site 716541015855 dimerization interface [polypeptide binding]; other site 716541015856 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 716541015857 TM-ABC transporter signature motif; other site 716541015858 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 716541015859 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 716541015860 Walker A/P-loop; other site 716541015861 ATP binding site [chemical binding]; other site 716541015862 Q-loop/lid; other site 716541015863 ABC transporter signature motif; other site 716541015864 Walker B; other site 716541015865 D-loop; other site 716541015866 H-loop/switch region; other site 716541015867 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 716541015868 D-ribose pyranase; Provisional; Region: PRK11797 716541015869 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 716541015870 regulatory ATPase RavA; Provisional; Region: PRK13531 716541015871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 716541015872 Walker A motif; other site 716541015873 ATP binding site [chemical binding]; other site 716541015874 Walker B motif; other site 716541015875 arginine finger; other site 716541015876 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 716541015877 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 716541015878 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 716541015879 metal ion-dependent adhesion site (MIDAS); other site 716541015880 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 716541015881 dimer interface [polypeptide binding]; other site 716541015882 active site 716541015883 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 716541015884 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 716541015885 putative DNA binding site [nucleotide binding]; other site 716541015886 putative Zn2+ binding site [ion binding]; other site 716541015887 AsnC family; Region: AsnC_trans_reg; pfam01037 716541015888 FMN-binding protein MioC; Provisional; Region: PRK09004 716541015889 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 716541015890 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 716541015891 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 716541015892 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 716541015893 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 716541015894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 716541015895 S-adenosylmethionine binding site [chemical binding]; other site 716541015896 ATP synthase I chain; Region: ATP_synt_I; cl09170 716541015897 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 716541015898 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 716541015899 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 716541015900 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 716541015901 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 716541015902 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 716541015903 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 716541015904 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 716541015905 beta subunit interaction interface [polypeptide binding]; other site 716541015906 Walker A motif; other site 716541015907 ATP binding site [chemical binding]; other site 716541015908 Walker B motif; other site 716541015909 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 716541015910 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 716541015911 core domain interface [polypeptide binding]; other site 716541015912 delta subunit interface [polypeptide binding]; other site 716541015913 epsilon subunit interface [polypeptide binding]; other site 716541015914 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 716541015915 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 716541015916 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 716541015917 alpha subunit interaction interface [polypeptide binding]; other site 716541015918 Walker A motif; other site 716541015919 ATP binding site [chemical binding]; other site 716541015920 Walker B motif; other site 716541015921 inhibitor binding site; inhibition site 716541015922 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 716541015923 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 716541015924 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 716541015925 gamma subunit interface [polypeptide binding]; other site 716541015926 epsilon subunit interface [polypeptide binding]; other site 716541015927 LBP interface [polypeptide binding]; other site 716541015928 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 716541015929 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 716541015930 Substrate binding site; other site 716541015931 Mg++ binding site; other site 716541015932 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 716541015933 active site 716541015934 substrate binding site [chemical binding]; other site 716541015935 CoA binding site [chemical binding]; other site 716541015936 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 716541015937 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 716541015938 glutaminase active site [active] 716541015939 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 716541015940 dimer interface [polypeptide binding]; other site 716541015941 active site 716541015942 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 716541015943 dimer interface [polypeptide binding]; other site 716541015944 active site 716541015945 phosphate ABC transporter periplasmic substrate-binding protein PstS; Provisional; Region: PRK10918 716541015946 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 716541015947 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 716541015948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541015949 dimer interface [polypeptide binding]; other site 716541015950 conserved gate region; other site 716541015951 putative PBP binding loops; other site 716541015952 ABC-ATPase subunit interface; other site 716541015953 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 716541015954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 716541015955 dimer interface [polypeptide binding]; other site 716541015956 conserved gate region; other site 716541015957 putative PBP binding loops; other site 716541015958 ABC-ATPase subunit interface; other site 716541015959 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 716541015960 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 716541015961 Walker A/P-loop; other site 716541015962 ATP binding site [chemical binding]; other site 716541015963 Q-loop/lid; other site 716541015964 ABC transporter signature motif; other site 716541015965 Walker B; other site 716541015966 D-loop; other site 716541015967 H-loop/switch region; other site 716541015968 transcriptional regulator PhoU; Provisional; Region: PRK11115 716541015969 PhoU domain; Region: PhoU; pfam01895 716541015970 PhoU domain; Region: PhoU; pfam01895 716541015971 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 716541015972 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 716541015973 active site 716541015974 motif I; other site 716541015975 motif II; other site 716541015976 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 716541015977 Predicted flavoprotein [General function prediction only]; Region: COG0431 716541015978 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 716541015979 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 716541015980 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 716541015981 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 716541015982 trmE is a tRNA modification GTPase; Region: trmE; cd04164 716541015983 G1 box; other site 716541015984 GTP/Mg2+ binding site [chemical binding]; other site 716541015985 Switch I region; other site 716541015986 G2 box; other site 716541015987 Switch II region; other site 716541015988 G3 box; other site 716541015989 G4 box; other site 716541015990 G5 box; other site 716541015991 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 716541015992 membrane protein insertase; Provisional; Region: PRK01318 716541015993 YidC periplasmic domain; Region: YidC_periplas; pfam14849 716541015994 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 716541015995 ribonuclease P; Reviewed; Region: rnpA; PRK01732 716541015996 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399